Researchers uncover what drives aggressive bone cancer
Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
A marine worm offers clues about our evolutionary past
The Arendt Group at EMBL Heidelberg focuses on mechanisms of evolution, studying Platynereis dumerilli – evolutionarily ancient marine worms found broadly along European coasts.
SCIENCE & TECHNOLOGY2025
science-technology
Sweet gene regulation in the mammalian embryo
Researchers in the Boulard group at EMBL Rome demonstrated that the catalytic activity of the OGT enzyme is essential for embryonic development, and that when it’s reduced, embryo development is delayed – especially in males.
SCIENCE & TECHNOLOGY2025
science-technology
Common cough syrup ingredient shows promise in treating serious lung disease
EMBL scientists discovered that dextromethorphan, an FDA-approved active ingredient in cough syrups, has potential to treat fibrotic lung disease by containing collagen and other pro-fibrotic molecules capable of forming scars inside the cells.
SCIENCE & TECHNOLOGY2024
science-technology
A new EMBL microscope hits the road
The Prevedel group at EMBL Heidelberg developed a mobile microscope: miniature in scale, fast in sample imaging, and giant in resolution.
SCIENCE & TECHNOLOGY2024
science-technology
Speaking the language of DNA
Right from the early days of DNA sequencing, EMBL’s scientists have been instrumental in helping the world understand, decode, archive, and manipulate genomes at scale and across many branches of the evolutionary tree, a task they continue to excel at today.
SCIENCE & TECHNOLOGY2024
science-technology
From snapshots to motion: watching biology in action
With a novel approach, EMBL scientists discovered important interactions between molecular machines, potentially offering new opportunities for drug development.
SCIENCE & TECHNOLOGY2024
science-technology
Sea anemone study shows how animals stay ‘in shape’
Scientists have shown how regenerating sea anemones restore their shape following a major injury, uncovering novel cellular and molecular mechanisms.
SCIENCE & TECHNOLOGY2024
science-technology
Sparking a data revolution
The introduction of computational methods in biology opened up an entirely new world of insights and breakthroughs. Over the last several decades, EMBL has been at the forefront of discoveries and innovations that have not only propelled the field forward but also opened up access to bioinformatics…
SCIENCE & TECHNOLOGY2024
science-technology
Making sense of RNA: five key insights from a recent EMBO | EMBL Symposium
A recent symposium on ‘The complex life of RNA’ brought together scientists from across the world interested in exploring one of the most crucial molecules essential to life.
SCIENCE & TECHNOLOGY2024
science-technology
Stopping severe malaria by harnessing natural human antibodies
The findings of the study provide insights into vaccines or treatments to protect people from severe malaria.
SCIENCE & TECHNOLOGY2024
science-technology
From head to tail: how cells give rise to our body plan
Researchers from the Trivedi Group at EMBL Barcelona unveil how cells can act autonomously during early development.
SCIENCE & TECHNOLOGY2024
science-technology
Picky proteins: understanding yeast adaptor protein selectivity
Scientists from EMBL Hamburg and CSSB have revealed key insights into the cellular process of clathrin-mediated endocytosis.
SCIENCE & TECHNOLOGY2024
science-technology
Microbial load can influence disease associations
Scientists have developed a new machine-learning model to predict microbial load — the density of microbes in our guts — and used it to demonstrate how microbial load plays an important role in disease-microbiome associations.
SCIENCE & TECHNOLOGY2024
science-technology
Making in situ serial crystallography more accessible
Nicolas Foos, a postdoctoral fellow at EMBL Grenoble, talks about the implementation of a new method for in situ serial crystallography developed during his ARISE fellowship.
SCIENCE & TECHNOLOGY2024
science-technology
Evaluating the link between chemicals and declining insect populations
Employing a library of more than 1,000 chemicals, EMBL researchers and collaborators investigated how agrochemicals affect insect populations.
SCIENCE & TECHNOLOGY2024
science-technology
The cellular superhero that protects us against RNA viruses
Scientists have discovered how the antiviral protein TRIM25 finds and binds viral RNA to activate an innate immune response.
SCIENCE & TECHNOLOGY2024
science-technology
Seeing is understanding
Imaging lets us observe biology in action – it makes visible the hidden processes of life. From its founding, EMBL has been a centre of breakthroughs and developments in bioimaging, and it continues to play a pioneering role in this field today.
SCIENCE & TECHNOLOGY2024
science-technology
Vitamin B1’s journey in your body, and why it matters
EMBL Hamburg scientists have gained molecular insights into how we absorb vitamin B1 – a mechanism with implications for disease and drug development.
SCIENCE & TECHNOLOGY2024
science-technology
“Structurally” sound
The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.
SCIENCE & TECHNOLOGY2024
science-technology
Computational protein design and protein structure prediction win Nobel Prize in Chemistry
Creators of AI system AlphaFold receive 2024 Nobel Prize for Chemistry.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
Machine learning discoveries honoured with 2024 Nobel Prize for Physics
The prize was awarded to John J. Hopfield, Princeton University, USA, and Geoffrey Hinton, University of Toronto, Canada, for their seminal contributions to the foundational methods that enabled the development of machine learning.
SCIENCE & TECHNOLOGY2024
science-technology
What we can learn from hungry yeast cells
Scientists at EMBL Heidelberg and University of Virginia revealed a new cellular response to starvation: ribosomes attach to the mitochondrial outer membrane in a very unusual way, via their small subunit. The finding made in yeast might provide insights into how cancer cells survive the harsh…
SCIENCE & TECHNOLOGY2024
science-technology
Polygenic Score (PGS) Catalog increases diversity and usability of genetic data
Addition of data from more diverse populations to the Polygenic Score (PGS) Catalog and a new software tool for PGS calculation could help produce more equitable disease risk predictions.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
Better together: gut microbiome communities’ resilience to drugs
EMBL Heidelberg researchers compared the effect of drugs on isolated bacteria versus those growing in communities. This is the first study showing that bacteria are more resilient when in community due to cross-protection strategies. This could help researchers design more efficient therapies.
SCIENCE & TECHNOLOGY2024
science-technology
Silencing in action: how cells ‘repress’ genomic remnants of ancient viruses
Researchers have identified key cellular control sites that regulate gene expression and prevent the activation of ancient viral sequences in the genome.
SCIENCE & TECHNOLOGY2024
science-technology
EMBL-EBI’s open data resources for biodiversity and climate research
EMBL-EBI data resources help advance biodiversity and climate change research by enabling scientists to study species interactions, evolutionary processes, ecosystem health, and more.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
Follow the cellular road
An AI-enhanced advanced microscopy approach offers promise in better understanding glioblastomas, one of the deadliest brain cancers.
SCIENCE & TECHNOLOGY2024
science-technology
Seeing into the depths
EMBL scientists applied molecular engineering to build photoacoustic probes to label and visualise neurons deep within brain tissue.
SCIENCE & TECHNOLOGY2024
science-technology
The forces behind chromosome repulsion and attraction during cell division
EMBL Heidelberg researchers discovered how a protein switches between repelling and gluing chromosomes during cell division. This helps the mother cell to divide the genome equally into two daughter cells and cluster chromosomes inside the daughter nuclei, ensuring a successful cell division.
SCIENCE & TECHNOLOGY2024
science-technology
New insights on how bird flu crosses the species barrier
A new publication from the Cusack group sheds light on how a key avian influenza virus enzyme can mutate to allow the virus to replicate in mammals.
SCIENCE & TECHNOLOGY2024
science-technology
Developing a simple, cost-effective method to study an important protein modification
EMBL Grenoble researchers have come up with a new way to identify the targets of a crucial protein-modifying enzyme involved in diverse cellular processes.
SCIENCE & TECHNOLOGY2024
science-technology
Why clinical trials stop: the role of genetics
Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
Gut microbes implicated in bladder cancer
Study shows that gut bacteria can metabolise carcinogens and cause them to accumulate in distant organs, leading to tumour development.
SCIENCE & TECHNOLOGY2024
science-technology
Proteomics: a different lens for precision medicine
The dynamic world of proteomics is shaping the future of personalised medicine, but some obstacles stand in the way
SCIENCE & TECHNOLOGY2024
perspectivesscience-technology
IIT-EMBL: New molecules to modulate gene expression
A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.
SCIENCE & TECHNOLOGY2024
science-technology
Exploring microbial life in context
EMBL researchers and their partners have been studying microbial functions and interactions for the benefit of human and planetary health for the last two decades.
SCIENCE & TECHNOLOGY2024
science-technology
An enzyme with a smart friend
EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…
SCIENCE & TECHNOLOGY2024
science-technology
‘Invisible’ protein keeps cancer at bay
EMBL Hamburg scientists and collaborators discovered a new molecular mechanism in which an unstructured protein disables one of the main cancer-promoting proteins by gluing them into an elongated stack. Data from human patient samples support the role of this mechanism in prostate cancer…
SCIENCE & TECHNOLOGY2024
science-technology
Minecraft-ing our way into studying cell sorting
A theoretical model involving tiny Minecraft-like cubes can help us understand dynamic biological processes, such as cell sorting in embryos.
SCIENCE & TECHNOLOGY2024
science-technology
Case study: Discovering new enzymes to upcycle food waste
EMBL-EBI data resource helps scientists upcycle animal by-products.
SCIENCE & TECHNOLOGY2024
perspectivesscience-technology
Structure and function of new lysosome transporter revealed
The group of Christian Löw at EMBL Hamburg and CSSB, and collaborators from the Christian-Albrechts-University Kiel and CNRS & Université Paris Cité worked together to reveal the structure and function of a previously unknown lysosome transporter, MFSD1.
SCIENCE & TECHNOLOGY2024
science-technology
Genetic mosaicism more common than thought
Blood stem cells from healthy people carry major chromosomal alterations, a study in Nature Genetics by researchers at the Max Delbrück Center and the European Molecular Biology Laboratory (EMBL) finds. The discovery suggests that we are all genetic mosaics, which may contribute to ageing-related…
SCIENCE & TECHNOLOGY2024
science-technology
Predicting cancer risk on the basis of national health data
Large-scale study uses data from Danish health registries to predict individual risks of developing cancer
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
Exploring diversity in cell division
New research by EMBL scientists shows how different modes of cell division used by animals and fungi might have evolved to support diverse life cycles.
SCIENCE & TECHNOLOGY2024
science-technology
An epigenome editing toolkit to dissect the mechanisms of gene regulation
A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.
SCIENCE & TECHNOLOGY2024
science-technology
Father’s gut microbes affect the next generation
Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.
SCIENCE & TECHNOLOGY2024
science-technology
Researchers aim to use quantum computing to assemble and analyse pangenomes
Experts in quantum computing and genomics to develop new methods and algorithms to process biological data.
SCIENCE & TECHNOLOGY2024
announcementsscience-technology
A universal framework for spatial biology
SpatialData is a tool developed by EMBL scientists in cooperation with multiple research institutions to unify and integrate data from different omics technologies in a spatial environment, providing holistic insights into health and disease. Researchers can now freely access and use SpatialData…
SCIENCE & TECHNOLOGY2024
science-technology
When AI meets biology
A recent EMBO | EMBL conference provided a forum for researchers to share how AI is making a difference in biology and bioinformatics.
SCIENCE & TECHNOLOGY2024
science-technology
Building the cell’s splicing machine
New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.
SCIENCE & TECHNOLOGY2024
science-technology
‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention
New study uncovers the potential of immunotherapy in preventing breast cancer and creates the openly available Human Breast Cell Atlas.
SCIENCE & TECHNOLOGY2024
research-highlightssciencescience-technology
Casting new light on gene regulation in development
New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
The malaria parasite generates genetic diversity using an evolutionary ‘copy-paste’ tactic
Plasmodium falciparum, a malaria parasite, uses gene conversion to produce genetic diversity in two surface protein genes targeted by the human immune system.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
Team SAMBAI: addressing cancer disparities in recent African heritage populations
An international team of researchers aim to combine social determinants of health with genomics, immune profiling, and exposomics data to tackle cancer inequities at an unprecedented scale.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
Studying the relationship between cancer-promoting proteins
A new study from the Bhogaraju Group at EMBL Grenoble reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
TREC in 2024: bringing it home
The Traversing European Coastlines (TREC) expedition prepares to begin its next phase of sampling, with stops in Spain, Greece, Italy, and beyond.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
Ancient ‘relaxant-inflammatory’ response gets sponges moving
Sponges lack muscles and neurons. Yet, they make coordinated movements. Scientists at EMBL Heidelberg have discovered that sponge movement is controlled by an ancient ‘relaxant-inflammatory’ response that is also present in vertebrate blood vessels. The findings shed light on sponge physiology…
SCIENCE & TECHNOLOGY2024
sciencescience-technology
Six takeaways from the EMBL conference Cancer Genomics 2023
Approximately 300 scientists met up at EMBL Heidelberg to unravel the centuries-old puzzle of cancer through the modern lens of genomics.
SCIENCE & TECHNOLOGY2024
eventsscience-technology
RNA to rule them all
The Kosinski Group at EMBL Hamburg collaborated with other groups in Hamburg to reveal critical steps in Lassa virus ribonucleoparticle assembly and recruitment, and the crucial role played by RNA in in the Lassa virus life cycle.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Unravelling the role of immune cells in early lung development
Researchers reveal that healthy lung development hinges on immune-epithelial crosstalk, with implications for respiratory diseases.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
Unveiling the vulnerabilities of pulmonary neuroendocrine tumours
A new organoid model mimics the behaviour of neuroendocrine tumours (NETs), providing a novel and invaluable tool to study the disease in the lab.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
‘X-ray vision’ for investigation of mRNA nanomedicines
EMBL Hamburg, Johannes Gutenberg University Mainz, Postnova Analytics GmbH, and BioNTech SE have developed a new method to quantitatively investigate sizes of nanoparticles containing mRNA. It may become an important part of regular characterisation of mRNA nanomedicines in the future.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Using artificial intelligence to discover therapeutic antibodies
Former EMBL staff scientist founds a start-up – DenovAI – for broader, faster and cheaper antibody discovery using advanced machine learning and computational biophysics.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
The Global Biodiversity Portal: enabling biodiversity research worldwide
The new initiative brings together genomic data from various biodiversity projects to aid conservation and biodiversity efforts.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
Hamburg collaboration paves the way to cleaner technologies for industry
An interdisciplinary collaboration between Hamburg scientists has yielded new insights into the structure and function of a heat-resistant enzyme from an exotic microbe. In this interview, EMBL Hamburg’s Matthias Wilmanns and TUHH’s Garo Antranikian discuss how their collaboration developed and…
SCIENCE & TECHNOLOGY2023
sciencescience-technology
New evidence on retinal function
A new study from the Asari group at EMBL Rome shows a different retinal function in awake mice compared to isolated retinal samples. These new insights could help to develop prosthetic devices that can act as a retina in the future.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Five takeaways from ‘Seeing is believing’ in 2023
A recent EMBO | EMBL symposium brought together leading developers of imaging methods with cutting-edge applications that illustrate how imaging can answer biological questions.
SCIENCE & TECHNOLOGY2023
eventsscience-technology
Spotlight: Creating an artificial uterus
EMBL researchers have created an engineered uterus that allows a closer look at a mouse embryo’s development and its interactions with the uterine environment.
SCIENCE & TECHNOLOGY2023
picture-of-the-weeksciencescience-technology
A promising target to fight inflammatory bowel diseases
Researchers from the Cusack group at EMBL Grenoble provide structural insights on the XIAP/RIPK2 complex, a promising drug target to fight inflammatory bowel diseases.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Six symposium takeaways about human microbiome research
Here are six takeaways from a recent EMBO/EMBL symposium that brought together scientists to discuss the state of research involving the human microbiome and its connection to health and disease.
SCIENCE & TECHNOLOGY2023
eventsscience-technology
Fighting antimicrobial resistance with new drug combinations
In an extensive investigation, EMBL researchers have tested over 10,000 drug combinations against some of the leading pathogenic bacteria carrying antimicrobial resistance and causing mortality.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Understanding developmental plasticity in time and space
A two-week practical course introduced participants to the intricacies of studying the dynamic interplay between organisms and their changing environment and how it impacts development and evolution.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Spotlight: Seeing into the seas
A new method developed by EMBL scientists can help us identify and investigate plankton species in field samples with greater speed, accuracy, and resolution than ever possible before.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
mRNA nanomedicines scoop Nobel Prize in Physiology or Medicine
Pioneers of the mRNA nanomedicines technology receive 2023 Nobel Prize in Physiology or medicine. EMBL is pleased to have supported the development of the application of the mRNA nanomedicine technology through our long-standing collaboration with BioNTech, Johannes Gutenberg University Mainz and…
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Understanding the mechanisms of enzyme catalysis
Enzymes constitute a large fraction of genomes – 20% in humans – which makes them a very important part of life. Despite decades of studies and a rich literature dedicated to understanding the reaction mechanisms of enzymes, the rules of enzyme catalysis are still not fully clear. A new…
SCIENCE & TECHNOLOGY2023
science-technologytechnology-and-innovation
New predictions of genetic variant pathogenicity using AlphaFold protein structures
Ensembl Variant Effect Predictor integrates Google DeepMind’s new AlphaMissense Database for better predictions of genetic variant pathogenicity.
SCIENCE & TECHNOLOGY2023
science-technologytechnology-and-innovation
Global guidelines to improve the quality of microscopy images in scientific publications
A working group of researchers from the QUAREP-LiMi initiative has developed global guidelines to improve the quality of microscopy data and images published in scientific publications.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Switching off the cytokine storm
EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Uncovering the mechanisms underlying lack of response to immunotherapy
New research improves understanding of the molecular mechanisms behind why some cancers respond to immunotherapy and others don't.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Revealing the secrets of protein evolution using the AlphaFold database
Researchers use the AlphaFold database and Foldseek Cluster algorithm to analyse millions of predicted protein structures and offer new insights into protein evolution.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Understanding how cells avoid obstacles
EMBL researchers have identified a novel mechanism that allows cells to sense obstacles in their path and avoid them while navigating complex environments.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
TREC: Exploring the ocean’s oxygen supply
As part of the EMBL-led Traversing European Ecosystems (TREC) expedition, scientists are studying plankton to understand biodiversity, health, and our planet’s future.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Swordfish sword under X-rays: SAXS explained
Learn how scientists use bio-SAXS, an experimental X-ray technique, to study the shape and dynamics of proteins and other biomolecules. SAXS can be even used to analyse the structure of mineral particles in the swordfish sword bone, which can help scientists better understand bone ageing.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Spotlight: Off to the pole
For a fruit fly embryo to develop correctly, key factors need to get to the right place at the right time – a journey that starts in the developing egg, as seen in this image from the Ephrussi Group at EMBL Heidelberg
SCIENCE & TECHNOLOGY2023
picture-of-the-weeksciencescience-technology
Deciding when to destroy mRNA
Elena Conti will discuss how cells control the life and death of mRNA molecules at the next annual Kafatos Lecture on 20 October in Munich.
SCIENCE & TECHNOLOGY2023
alumniscience-technology
Novel algorithm able to detect mutations in single-cell sequencing data sets
SComatic enables researchers to link genotype to phenotype using only single-cell profiling data
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Bringing advanced life science technologies to the field
EMBL’s newly deployed Advanced Mobile Laboratory (AML) is bringing cutting-edge technologies to the European coast to help researchers study ‘life in context’.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Imaging-based spatial-omics: EMBO Practical Course at EMBL Rome
The first EMBO Practical Course on imaging-based spatial-omics was organised at EMBL Rome to explore the latest techniques to visualise RNA transcripts and proteins in their native tissues.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
New therapies to improve cardiovascular health
EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
A glimpse into the hexasome: 40 years on
Research from the Eustermann group at EMBL Heidelberg reveals how the packaging of DNA into hexasomes impacts the function of enzymes involved in gene regulation.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
The power of cell sorting: understanding heart disease, phase separation, plankton, and more
EMBL researchers use a new cell sorting technology to gain new insights into cellular function in health and disease, as well as for other innovative applications.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Spotlight: Shedding light on deadly parasites
This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterspicture-of-the-weekscience-technology
Facilitating drug discovery against COVID-19
A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Pathogens Portal: The new gateway to public pathogen data
Enabling researchers worldwide to share and analyse pathogen data generated across the world
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Bringing research on disordered proteins to order
A third of all known proteins are either completely or partially unstructured. EMBL scientists contributed to a new set of guidelines – Minimum Information About a Disorder Experiment (MIADE) – that will help researchers share data on unstructured proteins in a more useful way and will enable…
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Supporting the development of hologenomic approaches for more sustainable animal feeds
HoloFood, the first consistent collection of multiomic data about chicken and salmon gut microbiomes, set to enable the development of better animal feeds.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
The speed of life: a zoo of cells to study developmental time
Researchers from the Ebisuya Group at EMBL Barcelona have used an unprecedented stem cell zoo to compare six different mammalian species and their developmental time.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
An organisation and its environment
A recent EMBL conference brought together scientists from various disciplines to conjoin scientific pursuits studying ‘life in context’.
SCIENCE & TECHNOLOGY2023
eventsscience-technology
Genomic medicine: ushering in a new era in healthcare
EMBL-EBI data resources are being used to deliver thousands of genetic diagnostics to patients every month.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
ProtVar: understanding missense variation in humans
A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
What happens when chromosomes shatter
Understanding chromothripsis offers insights into how cancer develops.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
A more diverse human reference genome
The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
Time-resolved crystallography for the masses
EMBL Hamburg scientists have contributed to the development of the Spitrobot, a ground-breaking experimental setup that will simplify creating molecular movies. The Spitrobot automates the sample preparation for time-resolved crystallography, which is used to create 3D snapshots of protein…
SCIENCE & TECHNOLOGY2023
sciencescience-technology
The hairy single-celled Tetrahymena provides a work reset
Dey Group holds second annual ‘labbatical’ to step outside daily research tasks with the help of single-celled model organisms.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Bioinformatics powers international effort to map gene function
EMBL-EBI is making a key contribution to a historic effort to understand the function of every human gene
LAB MATTERSSCIENCE & TECHNOLOGY2023
announcementslab-mattersscience-technology
WormBase ParaSite 18 released
WormBase ParaSite release 18 adds largest number of new genomes and annotations since launch, as well as full integration with AlphaFold.
SCIENCE & TECHNOLOGY2023
science-technologyupdates-from-data-resources
MAPLE: a phylogenetic tool for pandemic-scale genome data
EMBL-EBI researchers have developed a new tool capable of performing state-of-the-art phylogenetic inference on larger datasets than previously thought possible.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Life in context
Upcoming EMBO/EMBL symposium provides a forum to explore how organisms function together, and how they react or adapt to changes at different molecular levels.
SCIENCE & TECHNOLOGY2023
eventsscience-technology
Dispensing microscopy expertise
Home to some of Europe’s most cutting-edge tools in molecular biology, EMBL has long shared its expertise and access to these tools through an extensive repertoire of courses, conferences, seminars, and other training. And now included in this mix is a job shadowing programme at EMBL Imaging…
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Shining light on the mechanics of embryo development
A new microscope built by EMBL researchers, based on Brillouin scattering principles, allows scientists to observe the dynamics of mechanical properties inside developing embryos in real time.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterssciencescience-technology
Biology meets engineering
Physicists, engineers and robotics experts work together in EMBL Hamburg’s Instrumentation Team to design instruments that support structural biology research. The team has finished a transfer robot that facilitates automated handling of protein crystals with care and precision. This will help…
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Spotlight: Using light and sound to see into the brain
Researchers in the Prevedel Group use photoacoustic spectroscopy setup to test and optimise probes before their usage in mouse neuroscience.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterspicture-of-the-weekscience-technology
New EU-funded Project: Fragment-Screen
EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Supporting scientists across Europe: the SPC Facility at EMBL Hamburg
EMBL Hamburg’s Sample Preparation and Characterisation (SPC) Facility offers scientists access to almost all available biophysics technologies. The facility’s staff provides advice and support with experiments and data analysis. The facility is conveniently located just next to the EMBL…
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Machine learning to identify and prioritise drug targets
Open Targets is using artificial intelligence and machine learning to identify and prioritise drug targets.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Spotlight: A ‘devil’ of a flatworm
Tasmanian flatworms add to an EMBL researcher’s collection as she studies principles that control animal body size.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterspicture-of-the-weekscience-technology
Spotlight: Colours of the colon
Mucus present in the mouse colon can be visualised using Alcian blue staining, as imaged here by EMBL predoctoral fellow Linda Decker.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterspicture-of-the-weekscience-technology
Darwin Tree of Life: first 500 genome assemblies released as project creates a buzz
We look back through some of the 2022 highlights from the Darwin Tree of Life project.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
New molecular insights on medical cannabis
EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Step-by-step guide to nuclear pore complex assembly
EMBL Heidelberg researchers and their collaborators reveal how the nuclear pore complex, one of the biggest molecular machines in eukaryotic cells, is assembled one protein at a time.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
BOSS-RUNS: streamlining dynamic nanopore sequencing
A new method developed by EMBL-EBI researchers helps to streamline nanopore sequencing in real-time.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Spotlight: Zebrafish embryos to make this season jolly
Zebrafish embryos during gastrulation, a very early stage of development, to study the effect of temperature on vertebrate embryo development.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-matterspicture-of-the-weekscience-technology
Spotlight: Establishing a colour palette for antibiotic resistance
To identify which drugs disrupt bacterial envelope integrity, the Typas group uses a molecule called chlorophenyl red-β-D-galactopyranoside.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-matterspicture-of-the-weekscience-technology
Getting closer to stopping toxoplasmosis infection
Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Six enlightening questions about ‘plasticity across scales’
A recent EMBO|EMBL symposium provided a forum for discussing recent research on a range of issues for organisms as they cope with changing environments.
SCIENCE & TECHNOLOGY2022
eventsscience-technology
Two in one: combining MASSIF-1 and CrystalDirect
Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Teaming up to drive forward time-resolved crystallography
The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Examining life along Iceland’s coasts
The final pilot project in Iceland marked the countdown to the ‘Traversing European Coastlines’ (TREC) expedition to study coastal ecosystems and their response to changes in the environment.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Seeing antibiotics in action inside a pathogenic bacterium
New research by EMBL scientists shows at atomic detail how antibiotics affect the process of protein production inside bacteria.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Combi-seq: a leap forward for personalised cancer therapy
Researchers have come up with a way to test the efficacy of hundreds of anticancer drug combinations – simultaneously, rapidly, and accurately.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
PETRA IV and future opportunities at EMBL Hamburg beamlines
EMBL joined a kick-off event focusing on the developments related to the upgrade of the PETRA III synchrotron storage ring to PETRA IV at the DESY campus, where EMBL Hamburg is located. PETRA IV could open new possibilities at EMBL Hamburg, contributing to the goals of the EMBL Programme…
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Does exercise drive development? In the sea anemone, the way you move matters.
The latest research from EMBL’s Ikmi group employs interdisciplinary approaches to show how sea anemone ‘exercise’ changes their developing size and shape, uncovering an intimate relationship between behaviour and body development
SCIENCE & TECHNOLOGY2022
sciencescience-technology
When microbiomes collide
EMBL researchers used data from over 300 human faecal microbiota transplants to gain an ecological understanding of what happens when two gut microbiomes clash.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
ERC Proof-of-Concept grant provides way to realise commercial potential of ‘SpaceM’ technology
A new grant will provide a way for fundamental metabolomic research to realise its commercial potential and promise in aiding drug development and precision medicine.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Building the ideal limb
EMBL researchers use a “fearless” computer reconstruction and a two-centuries-old mathematical approach to study limb bud growth.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Spotlight: A giant in action
Physarum polycephalum, a single, giant cell containing tens of thousands of nuclei is large enough to be photographed with a phone.
SCIENCE & TECHNOLOGY2022
picture-of-the-weekscience-technology
CNest: a new method for copy number variation analysis
A new method for the robust analysis of copy number variation and used UK Biobank data to identify links between genome and disease.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
New antibiotic resistance genes identified in tuberculosis
International consortium analyses the genetic sequences and antibiotic susceptibility of 10,000 global Mycobacterium tuberculosis isolates.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Making patterns visible
How do gene expression patterns result in the generation of different cell types? Scientists at EMBL Heidelberg used the zebrafish notochord to find out.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Zooming in to get the full picture
EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Shining a light on how bacteria interact
Machine learning has helped researchers uncover new insights into how bacteria infect host cells.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
AlphaFold predicts structure of almost every catalogued protein known to science
AlphaFold database offers a look at 3D protein universe.
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
The retron switch
EMBL researchers now understand the function of an elusive small DNA in bacteria and have developed a tool that can be used to better understand what might ‘switch on’ bacterial immune defences.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
EMBL Rome’s Gene Editing and Embryology Facility generates transgenic mice to understand human diseases
The GEEF facility at EMBL Rome supports scientists worldwide with scientific expertise and state-of-the-art gene editing technologies.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Priorities for ocean microbiome research
Microbial communities play essential roles in ocean ecology and planetary health. A recent publication highlights priorities for understanding and protecting ocean microbiomes.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Uncharted territories in the human genome
Scientists identify previously unexplored gene segments to be added to human genome databases.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
The new heroics of RNA in cell differentiation
EMBL research with Enolase 1 (ENO1) points to a possible new way to understand RNA’s leading role in how cells develop.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Puzzling out the structure of a molecular giant
Scientists have solved several mysteries around the structure and function of a true molecular giant: the human nuclear pore complex. They created the most complete model of the complex thanks to combining the program AlphaFold2 with cryo-electron tomography, integrative modelling, molecular…
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Shaping up the genome for cell division
Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Impact of DNA mutations on blood cell production uncovered
Researchers discover how DNA mutations change blood cell production and how this relates to ageing and cancer development.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
A machine learning approach for allocating gene function
Researchers in the Ensembl team are making the most of machine learning methods to speed up genome annotation pipelines
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
Europe PMC: Harnessing the power of text mining to accelerate life sciences research
How text mining collaborations benefit our research, data resources, and the wider scientific community.
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
Flip-flop genome
Researchers at EMBL Heidelberg found that inversions in the human genome are more common than previously thought, which impacts our understanding of certain genetic diseases.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
What do stem cell aggregates and whipped cream have in common?
EMBL researchers revise the old problem of sintering droplets to understand the mechanical properties of tissues.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Interpreting bioimages with deep learning
Virginie Uhlmann shares her tips for using deep learning for bioimage analysis in the life sciences.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Unravelling the origins of the human spine
Scientists at EMBL Barcelona have created for the first time a 3D in vitro model that recapitulates the periodic formation of human somites – structures that give rise to the spinal column.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
A metaphor for epigenetic inheritance
Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration
SCIENCE & TECHNOLOGY2022
sciencescience-technology
The MANE collaboration: working together to support genome science
Researchers from the MANE collaboration bring you the most comprehensive human genome annotation dataset to date.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Pathogen data sharing – key to pandemic preparedness
Researchers lay out a set of principles for open genomic data sharing or pathogens
SCIENCE & TECHNOLOGY2022
perspectivesscience-technology
From liquid to solid to drive development
Condensates are membraneless organelles that control specific functions within a cell. Scientists at EMBL Heidelberg have shown how the physical state of condensates can influence biological function.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Genomic sequencing aids the global Tuberculosis fight
Zamin Iqbal and his team are working with researchers all over the globe to help put a stop to Tuberculosis
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Darwin Tree of Life at EMBL-EBI: reaching the first major milestone
Our researchers highlight their contributions to the Darwin Tree of Life project and how new genome annotations helps to further biodiversity research
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Safeguarding African biodiversity through genomics
The African BioGenome Project aims to safeguard biodiversity and build bioinformatics capacity across Africa
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Putting Cryptococcus in context
EMBL’s imaging technology helps researchers gain insights in the fungus’ journey from the lung to the brain.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
An international study proposes stool analysis for early detection of pancreatic cancer
A molecular signature of 27 microorganisms in stool defines the high-risk population for the most common pancreatic cancer and could be used for early detection of the disease.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Deep learning models help predict protein function
Deep learning models can improve protein annotations and has helped expand the Pfam database.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Understanding genomes, piece by piece
Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
A 3D culture model to study embryo growth
A recent study by EMBL researchers proposes a new method to grow early embryos in the laboratory. With a 3D culture set-up, scientists can closely monitor the changes embryos undergo around the time of implantation.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Converging lenses on embryo development
Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
New genetic data policy must promote biodiversity conservation
Scientists urge the adoption of a sensible international policy for digital sequence information.
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Investing in Italy by translating EMBL expertise to the market
Experiences at EMBL Rome led former group leader to establish his start-up in Italy, developing a new generation of gene therapies.
LAB MATTERSSCIENCE & TECHNOLOGY2022
alumnilab-mattersscience-technologytechnology-and-innovation
Learning from Deep Learning: the inspirational story behind AlphaFold
DeepMind visits EMBL Heidelberg to discuss current and future implications of Artificial Intelligence for life science research.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Decoding the secrets of snake venom
EMBL Hamburg’s Grzegorz Chojnowski from the Wilmanns Group developed software called findMySequence, which identifies proteins’ amino-acid sequences based on electron cryo-microscopy and X-ray crystallography data. It’s useful for identifying unknown proteins in samples from natural sources.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Genomic data for biodiversity – a global challenge
An exploration of where in the world genomics methods are applied and where the data are used.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Cell sorting enters a new dimension
EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
The Earth Biogenome Project: on track and ready to ramp up
On track to reach an ambitious goal of 3,000 genomes sequenced by the end of 2022, what’s next for the Earth Biogenome Project?
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Capturing ‘snapshots’ of a crucial step in RNA splicing
The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
New bacteria and viruses found on human skin
Researchers have identified hundreds of new bacterial species and viruses in the human skin microbiome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Observing the secret life of molecules inside the cell
EMBL Hamburg’s Kosinski Group, the Beck Laboratory at the Max Planck Institute of Biophysics, and colleagues at EMBL Heidelberg recorded the nuclear pore complex contracting in living cells. They visualised the movement with an unprecedented level of detail with help of new software called…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Solving molecular puzzles to find the perfect fit
Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Darwin Tree of Life in 2021: tireless fieldwork and the first beautiful genomes
A look back at some of the 2021 highlights from the Darwin Tree of Life partner institutes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Artificial intelligence — a scientific game changer in 2021
The systematic application of AI in life sciences as in the AlphaFold algorithm for predicting protein structures has been named '2021 Breakthrough of the Year' by Science magazine.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Connecting the dots between bacterial genes around the world
Bork Group at EMBL Heidelberg analysed a new global gene database to study how genes emerge and spread across various habitats on our planet. In the future, the group will expand the database and use it for studying microbial gene evolution and dispersal at a finer-grained scale.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A gallery of human RNA polymerases
New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The impact of drugs on gut microbes is greater than we thought
Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
How structural biology helps to make RNA vaccines
RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines, and how structural biology contributes to its development. EMBL Hamburg collaborated on several…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Wrangling an octopus-like viral replication machine
EMBL structural biology is part of an international collaboration addressing zoonotic disease caused by Lassa virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Can data help feed a hungry world?
How genomics, open data, and multidisciplinary science can improve food security.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Addressing the biodiversity crisis with 12,000 reptiles – or one database
An alumnus reflects on the reptile database he started in 1996 while at EMBL. The database helps understand biodiversity issues.
SCIENCE & TECHNOLOGY2021
alumniscience-technology
Building a 3D placenta on a chip
A new model could serve as a platform to investigate critical placenta barrier phenomena, including defence against bacteria, viruses, and parasites.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
EMBL alum takes DNA sequencing to the field
EMBL alum Lara Urban has developed mobile DNA approaches to monitor impacts upon biodiversity in remote areas of New Zealand and elsewhere.
SCIENCE & TECHNOLOGY2021
alumniscience-technology
EMBL Imaging Centre welcomes first external user
Correlative microscopy service enables PhD student from Switzerland to study structure and location of proteins cells use to communicate.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
DUO: streamlining access to biomedical datasets
The GA4GH Data Use Ontology (DUO) supports a data authorisation and access framework to streamline consent to use biomedical data
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL experimental services enable European researchers to tackle global societal challenges
Independent impact review finds EMBL experimental services are ‘critical’ for research and endorses EMBL as a world-class service provider for academia and industry.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
Making sense of bacterial DNA data
A vast, curated collection of bacterial genomes is now organised, searchable and open to the community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL Hamburg trains future generations of life scientists in using SAXS
Each year, EMBL Hamburg’s Svergun Group offers practical EMBO courses and lecture courses on biological small-angle X-ray scattering (SAXS). The courses provide young scientists an opportunity to gain hands-on experience by measuring their own samples, and by exploring different aspects of SAXS…
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
More than a gut reaction
What can sponges tell us about the evolution of the brain? Sponges have the genes involved in neuronal function in higher animals. But if sponges don’t have brains, what is the role of these? EMBL scientists imaged the sponge digestive chamber to find out.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Structure of a promiscuous protein will help scientists design better drugs
Scientists at EMBL Hamburg determined the molecular structure of Peptide Transporters 1 and 2. The findings will enable developing drugs that more efficiently pass from the gut to target tissues.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Open data on the rise: the value of EMBL-EBI data resources
Independent study reveals that EMBL-EBI open data resources are critical for the life sciences.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
Genomic sequencing to strengthen biodiversity
The Darwin Tree of Life project is an unprecedented initiative sequencing 70,000 species
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Harnessing the microbiome to improve meat production
International project uses biomolecular data to improve animal feed and make meat production more sustainable
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Novel enzymes for a Green Economy
Using metagenomic data to find novel enzymes for plastic degradation and beyond
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Biophysics analysis made easy with an online tool
EMBL Hamburg’s Sample Preparation and Characterisation (SPC) Facility has released eSPC, an online platform for analysing data from biophysical experiments. The platform enables the scientific community to analyse data from different experiments without the need to travel.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Analysis and sorting with flow cytometry
A technology around since the ‘60s, flow cytometry has increasing applications. New leadership at EMBL’s flow cytometry facilities is looking to ease use, expand training, and encourage more collaboration.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
BY-COVID – a new EU project for pandemic preparedness
The BY-COVID project aims to make infectious disease data, including COVID-19, openly available to everyone.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
CRyPTIC: cataloguing drug resistance mutations in M. tuberculosis
Profiling M. tuberculosis strains from 27 countries to reveal causes of drug resistance.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Characterising protein phosphosite function at scale
Researchers develop a new high-throughput approach to assess the functional significance of protein phosphosites.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
How herpes seizes proteins’ means of production
The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Genomic tracking of the COVID-19 pandemic in England
Largest in-depth analysis of genomic data tracks the spread of SARS-CoV-2 lineages in England.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Tackling the collateral damage from antibiotics
Researchers from EMBL’s Typas group and collaborators have analysed the effects of 144 antibiotics on the wellbeing of gut microbes. The study improves our understanding of antibiotics’ side effects and suggests a new approach to mitigating the adverse effects of antibiotics therapy on gut…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
When ‘good’ cells go ‘bad’
If researchers can identify specifically when good cells go bad, they can potentially understand disease better.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Six Ways to Protect the Planet Against Pandemics*
EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.
SCIENCE & TECHNOLOGY2021
eventsscience-technology
From creating new antimicrobials to combating Alzheimer’s disease
Structural biology provides insights into the diverse functions of fibrous protein in humans, amphibians, and bacteria.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A cellular atlas of an entire worm
EMBL scientists and colleagues have developed an interactive atlas of the entire marine worm Platynereis dumerilii in its larval stage. The PlatyBrowser resource combines high-resolution gene expression data with volume electron microscopy images.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
New microscopy technique makes deep in vivo brain imaging possible
Scientists in EMBL’s Prevedel Group have developed a pioneering microscopy technique that allows researchers to observe cells hidden within opaque tissues, such as live neurons embedded deep in the brain.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The secret life of baby octopuses
Some of the most amazing creatures live in the deep blue sea. The Mesoscopic Imaging Facility (MIF) at EMBL Barcelona was recently involved in studying one unique feature of the octopus: the ephemeral structures on the surface of their skin called Kölliker’s organs.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Organoids and machine learning: image analysis software developed during lockdown
MOrgAna is an open source, user-friendly, modular software that is able to analyse organoids with machine learning.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Vision unveiled: new roles for the retina in visual processing
EMBL scientists have found evidence of an unexpected role for retinal cells in pre-processing visual information; their results provide potential opportunity for future prosthetic visual aids.
SCIENCE & TECHNOLOGY2021
research-highlightssciencescience-technology
Charting a multi-omic universe
A research collaboration used machine learning to map tumour molecular make-up, potentially paving way to more customised cancer treatment.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Artificial neural networks revolutionise biological image analysis
Packaged for simple installation and free use, the novel method DECODE enables researchers to reduce imaging times and increase localisation density in single-molecule localisation microscopy (SMLM).
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Common medications accumulate in gut bacteria
A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A flip book for biological systems
In the Mesoscopic Imaging Facility (MIF) at EMBL Barcelona, researchers study the details of biological systems in the context of organs, body parts, or entire organisms. This image shows OPTiSPIM1, one of the custom light-sheet microscope setups available at the facility.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The Spatial Mouse Atlas: new insights into cell fate
Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Cryo-Electron Microscopy Service Platform supports research on protein transport
Giulia Zanetti from the Institute of Structural and Molecular Biology (ISMB) in London explains how the collaboration with the Cryo-Electron Microscopy Service Platform enabled her group to reveal the structure of protein transport complexes.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery
MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
All heart
A community of scientists is looking at the estimated three billion heart muscle cells in a human heart to better understand heart disease.
SCIENCE & TECHNOLOGY2021
alumniscience-technology
What lies beneath: the building blocks of life
Analysis of more than 2 million images has boosted understanding of ocean microbes, shedding light on the distribution of nitrogen-fixers at a global level
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Studying coronavirus proteins using small-angle X-ray scattering at European XFEL
A collaboration led by EMBL Hamburg’s Svergun Group used small-angle X-ray scattering (SAXS) at the European XFEL to obtain data on samples containing coronavirus spike proteins and antibodies that bind them.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins
Partners use AlphaFold, the AI system recognised last year as a solution to the protein structure prediction problem, to release more than 350,000 protein structure predictions including the entire human proteome to the scientific community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Accessible 3D protein models to accelerate scientific discovery
DeepMind and EMBL-EBI to make millions of protein structure predictions freely available to the scientific community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Great expectations – the potential impacts of AlphaFold DB
A discussion of the applications that AlphaFold DB may enable and the possible impact of the resource on science and society.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The PROTACtable genome – a new route to drug discovery
Researchers establish a framework for identifying new drugs capable of exploiting a cell’s own machinery.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A model of cooperation for transporting mRNA
EMBL scientists generate a high-resolution crystal structure of the Kinesin-1/aTm1 transport complex in the fruit fly.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
From antibodies to nanoplastics
EMBL’s Melissa Graewert and colleagues are taking a structural biologist’s approach to better understanding nanoplastic particles.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
New insights into Salmonella’s survival strategies
Research in the Typas group uncovers new details of the strategies Salmonella uses to survive in infected cells.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Structural biology reveals new opportunities to combat tuberculosis
EMBL Hamburg’s Wilmanns and Kosinski groups have determined the detailed structure of a bacterial protein complex critical for tuberculosis infection.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Starlet sea anemone
EMBL PhD student Anniek Stokkermans captured this side view of a Nematostella vectensis larva during this transition, using instrumentation in the Advanced Light Microscopy Facility at EMBL Heidelberg.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
How our gut microbiome changes over time
Researchers investigate how external factors can influence the persistence of microbe species in the human gut
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Twinkle, twinkle, little nuclear pore complex
As perfect as a summer night sky, these nuclear pores help calibrate a customised super-resolution microscope in EMBL’s Ries group.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Visualising RNA structures using R2DT
New software enables scientists to visualise RNA secondary structures using the world’s largest RNA structure dataset.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Dream team
At EMBL, we have many dream teams – groups of individuals who support each other, innovate, and work together. One of those dream teams bridges two core facilities at EMBL Rome.
SCIENCE & TECHNOLOGY2021
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Living laboratories
Under the innovative Planetary Biology research theme, EMBL scientists aim to understand life in the context of its environment.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Nuclear twins
Captured by EMBL postdoc Arina Rybina, these ‘nuclear twins’ are two daughter nuclei straight after division of a HeLa cell.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Genomic surveillance of SARS-CoV-2 in England
The largest in-depth analysis of genomic surveillance data mapping out the dynamics of 62 lineages of the SARS-CoV-2 virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Barriers against malaria
The Bernabeu Group aims to increase our knowledge of cerebral malaria, using in vitro engineered networks of human blood vessels and brain cells.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
EMBL scientists support malaria research
EMBL scientists support research on malaria by providing freely available data resources and using innovative experimental approaches. Our Course and Conference Office facilitates the exchange of knowledge in the field by hosting the annual BioMalPar conference.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Cellular fireball or immune cells?
The EMBL Picture of the Week features a series of Jurkat T cells during different stages of the activation process.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Reshaping the cell membrane with molecular pegs
Researchers at EMBL Hamburg reveal how peg-like proteins clasp and reshape the cell membrane
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Shaping the future of structural biology and X-ray imaging at EMBL Hamburg
A workshop run by EMBL Hamburg explored opportunities for structural biology at the future, upgraded PETRA IV synchrotron.
SCIENCE & TECHNOLOGY2021
eventsscience-technology
Artificial intelligence makes great microscopes better than ever
EMBL scientists have combined artificial intelligence (AI) algorithms with two cutting-edge microscopy techniques.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL provides key infrastructure for COVID-19 drug screening project
EMBL Hamburg’s integrated structural biology facility has contributed to the success of a large-scale SARS-CoV-2 study
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Piecing together the best reference genome
Researchers reveal the best technology for assembling reference genomes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
SARS-CoV-2 curtails immune response in the gut
EMBL scientists, together with collaborators from Heidelberg University, have provided further evidence of the gut’s role in COVID-19.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Painting liver cells
A page from a biologist’s colouring book? EMBL’s new interior wall design? Not quite – a bunch of liver cells, grown in the lab so that scientists can learn about fatty liver disease, or steatosis.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Different immune responses identified in patients with COVID-19
Researchers identify differences in immune response in asymptomatic COVID-19 cases compared to those with severe symptoms
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Variations on a spike
What does coronavirus’s spike protein look like in 3D? EMBL scientists and colleagues used cryo-electron tomography and molecular dynamics simulations to find out.
SCIENCE & TECHNOLOGY2021
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Using metagenomic techniques to explore lichens
Researchers have used a metagenomics approach to piece together the genomes of yeasts found in wild lichens.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Structural biology at EMBL: driving technology development
Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
Repurposing drugs to manage COVID-19 progression
Researchers use large-scale human genetic studies to identify drug targets important for managing COVID-19 in its early stages
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL Hamburg lights the way to folding next-level origami
Using EMBL Hamburg’s world-class structural biology infrastructure, researchers advance the folding of protein ‘origami’ designed in the lab.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Linking genetics and age-related diseases
Researchers have used human medical and genetic data from UK Biobank to investigate the genetics of age-related diseases
SCIENCE & TECHNOLOGY2021
sciencescience-technology
New perspectives for treating psychiatric disorders
Scientists have determined the structure of Glycine Transporter 1. The finding could open new avenues for developing therapeutics for psychiatric disorders
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A multifunctional mouth
This image of a young Nematostella vectensis polyp shows two of the characteristic tentacles as well as the gaping mouth of the animal.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Droplet beauty
Scientists at EMBL Hamburg use droplets of protein solution to grow protein crystals. By exposing the crystals to X-rays, they are able to determine the protein’s molecular structure.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Coronavirus vaccine uses EMBL’s earliest virus research
EMBL alumnus Kai Simons did early work with Semliki Forest virus membranes, which is now central to a COVID-19 vaccine.
SCIENCE & TECHNOLOGY2021
alumniscience-technology
Induced pluripotent stem cells reveal causes of disease
Scientists in the Stegle group and colleagues have studied induced pluripotent stem cells from around 1,000 donors to identify correlations between individual genetic variants and altered gene expression. They linked more than 4,000 of the genetic variants responsible for altered expression…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Pfam releases structures for every protein family
Thousands of new protein structure models, prected using deep learning, now available to explore
SCIENCE & TECHNOLOGY2021
sciencescience-technology
New avenues for eradicating cancer
A new method has the potential to boost international research efforts to find drugs that eradicate cancer at its source.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Sleeping beauty
Like caterpillars turning into beautiful butterflies, fruit fly larvae have to go through metamorphosis to finish their development. However, despite the fruit fly Drosophila melanogaster being one of the best studied model organisms in biology, comparatively little attention has been given to this…
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Human genomes provide new reference for global genetic diversity
A collaboration including EMBL scientists has created the most diverse set of reference human genomes ever assembled.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Seeing through a cell
Liang Xue used cryo-electron tomography to capture this detailed image of a Mycoplasma pneumoniae cell.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
The thousands of viruses living in your gut
Scientists identify more than 140 000 virus species in the human gut; more than half have never been seen before
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A new piece of the HIV infection puzzle explored
Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Finding coronavirus’s helper proteins
A team of EMBL scientists and colleagues have analysed how the novel coronavirus affects proteins in human cells. They identified several human proteins as potential drug targets to prevent viral replication.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Cellular modern art
This week's Picture of the Week, which could also be a masterpiece of modern art, shows the enzyme RNA polymerase III, an assembly of 17 individual proteins combined into this complex structure.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Protein sequences provide clues to how SARS-CoV-2 infects cells
Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Purity, beauty, and perfection
The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
A better look at a human RNA polymerase
New EMBL research shows where & to what degree a component of cellular machinery known as RNA Pol III is mutated and becomes problematic.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
At the core of the Integrator complex
A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Insights into the new B.1.1.7 coronavirus lineage
A new lineage of coronavirus was first identified in the UK, but why is it spreading much more rapidly within the population?
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The central dogma of molecular biology
This colourful image shows biological information flow in action: It’s a supramolecular assembly of DNA, RNA and proteins, observed directly inside a bacterial cell while turning genetic information into protein.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Mirror, mirror
Scientists at EMBL Hamburg use specially designed mirrors to reflect and focus X-ray beams onto tiny crystals made of proteins or other biological molecules.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
The SARS-CoV-2 B.1.1.7 lineage
A note on the coronavirus variant B.1.1.7, which has first been described in the U.K. and has spread to 57 countries. The note summarises epidemiological information about the spread of B.1.1.7 in the U.K. collated and in part conducted by researchers from EMBL-EBI.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Monitoring dangerous bacteria in freshwater
Freshwater sports can cause waterborne infections, but real-time DNA sequencing could help.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Cell under attack
It’s almost a year since the coronavirus outbreak was declared a pandemic, affecting all our lives. While the virus continues its grip on the world, scientists are understanding it better and better, increasing our knowledge about it and opening up new ways to fight it.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
Toadlet peptide transforms into a deadly weapon against bacteria
Researchers at the Technion – Israel Institute of Technology and EMBL Hamburg, in collaboration with scientists in Israel and Spain, have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Homage to a vital tool
Structural biologists want to study proteins at the atomic level. The device shown in this Picture of the Week is essential for this.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
It’s like a party in your brain
Fluorescent dyes light up a cellular community of neurons and brain immune cells (microglia), which were derived from stem cells.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
In kefir, microbial teamwork makes the dream work
Researchers discovered the dominant species of bacteria in kefir grains cannot endure without other species that help the 'team' survive.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Darwin Tree of Life: looking back on 2020
Despite restrictions, 2020 has been a busy year for the Darwin Tree of Life Project. We take a look at some of this year’s achievements and highlights.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Cells in the holiday spirit
It is that time of year to get into the holiday spirit, prepare for some time at home and relax after a strange and stressful year. Even the cells in our Picture of the Week are getting into the holiday spirit, forming this colourful Christmas tree.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
How EMBL alumni created a groundbreaking vaccine technology
The story of a life-long friendship and a professional partnership that sowed the seeds for a ground-breaking vaccine technology.
SCIENCE & TECHNOLOGY2020
alumniscience-technology
Stronger together
Gene activation requires the cooperative activity of multiple transcription factors. Until now, the mechanism used by these factors to coordinate their actions has been poorly understood. EMBL’s Krebs group presents a DNA footprinting method that makes it possible to determine whether…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Heating proteins to understand how genes work
A new paper from EMBL’s Savitski team and Typas group describes their work on E. coli and how it brings a greater understanding of the way genes function and interact.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Seeing deeper inside cells
While cryo-electron tomography (cryo-ET) was first envisioned in 1968, the advances the Mahamid group are bringing to this 3D method for studying molecules directly inside cells are new, and are likely to greatly expand its use.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Solving the protein structure puzzle
How artificial intelligence can help us solve the mysteries of the protein universe
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Scratching the surface on cell differentiation
Scientists in the Diz-Muñoz group at EMBL Heidelberg are working to build understanding of the role that mechanical properties play in affecting cell behaviour – a young and rapidly developing field of study. They have developed and successfully used a highly specialised technique to manipulate…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Tackling tropical diseases
Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL facilities support development of RNA vaccines
Biotechnology company BioNTech and Johannes Gutenberg University Mainz conduct collaborative research with EMBL scientists at the beamline P12 in Hamburg
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Repurposing bioinformatics tools to tackle the pandemic
Bioinformaticians at EMBL-EBI and beyond are adapting computational tools to investigate coronavirus genomes and proteins.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
A loopy baseline
Studying cancers means also knowing what healthy cells look like. In this case, mesenchymal stromal cells (MSCs) from healthy bone marrow are a bit ‘loopy’.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Replication cycle of SARS-CoV-2 in 3D
Researchers have studied SARS-CoV-2 replication in cells and obtained detailed insights into the alterations induced in infected cells. This information is essential to guide the development of urgently needed therapeutic strategies for suppressing viral replication and induced pathology.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding malaria
To help understand cerebral malaria the Bernabeu group has created in vitro engineered networks of human blood vessels.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Scientists identify synthetic mini-antibody to combat COVID-19
By screening hundreds of sybodies (synthetic mini-antibodies), scientists have identified one that might stop SARS-CoV-2 from infecting human cells. This work, which holds promise for treating COVID-19, was conducted by EMBL Hamburg and collaborators from the Centre for Structural Systems Biology…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Under the rainbow
On autumn days without Heidelberg’s characteristic fog, the woods present themself in beautiful colours. You may even capture a rainbow.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Should I run, or should I not? The neural basis of aggression and flight
Researchers in the Gross group at EMBL Rome have investigated the mechanism behind defensive behaviour in mice. They have identified a specific area of the brain that encodes both spatial and threat cues to drive location-specific defensive responses.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Party at the nucleus?
The nucleus of this cell fluoresces in bright green thanks to GFP-labelled nucleoporin proteins. EMBL scientists use engineered nucleoporins as 3D reference standards to improve super-resolution microscopy.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Bringing AI out of the black box
Why should researchers make artificial intelligence more transparent and how can they do it?
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
Open data sharing accelerates COVID-19 research
Open access data benefits millions of scientists around the world and is essential for a rapid response to the COVID-19 pandemic.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Repurposing drugs for a pan-coronavirus treatment
Scientists from the Beltrao Group at EMBL-EBI and collaborators identified drug targets common to SARS-CoV-2, SARS-CoV-1, and MERS-CoV, three pathogenic coronaviruses. They also found potential drugs that could be repurposed as COVID-19 treatments, and against emerging coronavirus strains in the…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Seeing evolution happening before your eyes
Researchers from EMBL Heidelberg have established an automated pipeline to create mutations in genomic enhancers, letting them watch evolution unfold before their eyes.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How deadly parasites ‘glide’ into human cells
A group of scientists led by EMBL Hamburg’s Christian Löw provide insights into the molecular structure of proteins involved in the gliding movements through which the parasites causing malaria and toxoplasmosis invade human cells.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Crazy arms
Sea anemones are amazing creatures. Despite their plant-like appearance and their tendency to remain fixed in one spot, they are actually animals.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Beyond the lens – microscopy at EMBL Rome
Research facilities play a crucial role in the advancement of science by supporting scientists with specialised expertise and state-of-the-art equipment. The Microscopy Facility at EMBL Rome exemplifies this role by making a wide variety of light microscopy technologies available to its researchers…
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
Powerful genome editing tool recognised by Nobel Prize in Chemistry
The genome editing tool CRISPR–Cas9 – which plays a critical role in EMBL’s research – was recognised by the Nobel Prize in Chemistry.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Deep learning captures cell cycle
Members of an EMBL-led research group with collaborators in Estonia and Russia have built and trained a deep learning model to better understand how cells grow and divide.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Time heals all wounds
We’ve all had wounds at certain times in our lives. But they heal due to the self-repairing mechanisms in the body.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Colourful test tubes
To study the effect of commonly used drugs on bacterial envelopes, EMBL scientists applied a biochemical assay using a colour reaction. The deeper the red, the stronger the disruptive effect of the drug.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Dinosaurs, dodos, and the future of life on Earth
EMBL’s 21st Science and Society Conference will address scientific and societal responses to mass extinctions. Ahead of his keynote speech, renowned palaeontologist Mike Benton explains how looking into the deep past can give us vital insights into the future of life on Earth.
SCIENCE & TECHNOLOGY2020
eventsscience-technology
A bloom of crystals
How does your crystal garden grow? EMBL's Electron Microscopy Core Facility was able to capture this garden of blooming crystals as they studied mosquito reproductive cells.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Human and mouse cells run at different speeds
The internal clock that governs the development of embryos ticks slower for humans than for mice. Differences in the speed of biochemical reactions underlie the differences between species in the tempo of development.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Fruit fly with a heart of gold
Not just another pretty fruit fly. This magenta and golden drosophila larva is lit up with a fluorescent molecule to help researchers study heart formation.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Fighting cardiovascular disease with acne drug
Researchers have found the cause of dilated cardiomyopathy – a leading cause of heart failure – and identified a potential treatment for it: a drug already used to treat acne.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Achieving personalised therapeutics
A decadal roadmap points the way to cell-based medicine for Europe
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
Not a galaxy far, far away
While this may seem like a nebula made up of interstellar clouds of dust and ionised gases, this image isn’t of a galaxy beyond the Milky Way.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Genome sequencing accelerates cancer detection
The Gerstung Group at EMBL-EBI and collaborators have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing oesophageal cancer.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Nuclear pores in their natural context
Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How to remove unwanted components from the cell nucleus
Researchers have uncovered how cells remove unwanted components from the nucleus following mitosis.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Eat more to grow more arms…if you’re a sea anemone
An international group of researchers, led by scientists from EMBL Heidelberg, have discovered that the number of tentacle arms a sea anemone grows depends on the amount of food it eats.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
A luminous larval love light
Those heart-shaped cells aren't just for show. They help tell the story of two proteins working together
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Intelligent software tackles plant cell jigsaw
Starting with computer code and moving on to a more user-friendly graphical interface called PlantSeg, the Kreshuk Group at EMBL and collaborators built a simple open-access method to provide the most accurate and versatile analysis of plant tissue development to date.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
COVID-19’s indirect attack on women
More than 500 people have registered for an EMBL conference, "The impact of the COVID-19 crisis on women in science: Challenges and solutions." Scheduled for 9 September, the conference is free and open to all. Pre-registration is still available and required to attend.
SCIENCE & TECHNOLOGY2020
eventsscience-technology
Breathing beneath the skin
Beautiful flashes of blue colour help light the way for researchers to study cells in fruit fly larva that provide oxygen to tissues.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
New clues to a 500-year old mystery about the human heart
An international team of scientists involving Ewan Birney's group has investigated the function of a complex mesh of muscle fibres that line the inner surface of the heart.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Predicting how gene expression varies
Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical studies.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Flexible and protected – new findings on SARS-CoV-2 protein shed light on virus’s ability to infect cells
Researchers studied the spike protein on the surface of the SARS-CoV-2 virus. With its spikes, the virus binds to human cells and infects them. The study gave surprising insights into the spike protein, including an unexpected freedom of movement and a protective coat to hide it from antibodies.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Three little ghosts
Despite their ghostly appearance, these are very real cell nuclei infected with Influenza A virus – the only influenza virus known to cause pandemics.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
The eye of science
This image is a composite of lateral pentascolopidial organs, a wing imaginal disc pouch, and an epithelial wound in a Drosophila larva. The organs are arranged here like eyelashes. Cells surrounding an epidermal wound appear as the iris and pupil of this artistic eye.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Bridging artificial intelligence and the life sciences – launch of ELLIS Heidelberg
Researchers from all life science disciplines – from fundamental biological research to medical applications – generate immense datasets. Analysing these datasets and gaining new knowledge from them is a growing challenge for scientists. The fields of artificial intelligence (AI) and machine…
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
The curious genome of the tuatara, an ancient reptile in peril
A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Fish close-up
This group of cells represents an interesting example of organ formation where cells simultaneously move and change their shapes in a highly coordinated manner.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Bagpipe and Pokemon, or how not to name a human gene
The human genome harbours about 19 000 protein-coding genes, many of which still have no known function. As scientists unveil the secrets of our DNA, they come across novel genes that they need to refer to using a unique name. The Human Genome Organisation’s Gene Nomenclature Committee (HGNC) at…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Visualising the cell’s molecular machinery in action
A new approach that allows researchers to see molecular machinery at work inside cells has offered a deeper understanding of how bacteria produce proteins and a unique glimpse into how they respond to antibiotics.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Europe PMC: unlocking the potential of COVID-19 preprints
Europe PMC has begun indexing full-text COVID-19 preprints along with the associated data. The project aims to accelerate research to fight the SARS-CoV-2 virus.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding chromosome organisation
EMBL scientists and collaborators help reveal the process by which enormous quantities of DNA are folded into cells.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
An ocean of droplets
Bacterial cells are embedded in microfluidic droplets in oil. The fluorescence indicates the presence of the targeted DNA strain with the help of a characteristic DNA sequence.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Artificial intelligence finds patterns of mutations and survival in tumour images
Researchers have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients. The algorithm can distinguish between healthy and cancerous tissues, and can also identify patterns DNA and RNA changes in tumours.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
A bright view of the future
The image shows one of the four rows of roof lights above the atrium, which is the main public space of the Imaging Centre.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
A tool to improve cancer research
EMBL scientists have created a new, realistic 3D testbed that could help achieve the goal of stopping cancers before they start by studying cancer cells as they first form.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unparalleled inventory of the human gut ecosystem
An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Muscular worm larva
The image shows a larva of Platynereis dumerilii, a marine worm. The image here was produced by Constantin Pape, a visiting predoctoral fellow in the Kreshuk group at EMBL Heidelberg.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
What COVID-19 is teaching us
The virtual EMBL Conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future.
SCIENCE & TECHNOLOGY2020
eventsscience-technology
From stem cells to neurons
Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unravelling epigenetic reprogramming
A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Editing the mouse genome to study SARS-CoV-2 infection
To study how SARS-CoV-2 infects cells, the Gene Editing and Embryology Facility (GEEF) at EMBL Rome will generate mice that express a human version of a protein called ACE2. The mouse line will be shared with preclinical research collaborators carrying out vaccine and antibody trials, and with the…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Existing drugs can prevent SARS-CoV-2 from hijacking cells
Researchers evaluate how the new coronavirus rewires human proteins for its own replication, and identify several antiviral drugs ready for clinical trials
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Five things you probably didn’t know about the Human Genome Project
Today we celebrate the 20th anniversary of the first draft of the entire human genome.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Silencing the SARS-CoV-2 receptor with epigenetic modifications
EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unpicking the complexity of DNA mutations
DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL survey studies effects of COVID-19 pandemic on life scientists
Jan Korbel and Oliver Stegle have performed a survey of fellow life scientists to learn how the current crisis, with partial or complete institutional shutdowns, is affecting their work.
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
Investigating the structure and mechanisms of coronavirus biomolecules
While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding how SARS-CoV-2 behaves in the gut
Scientists at EMBL and Heidelberg University Hospital are studying how the novel coronavirus behaves in the gut to try to better understand its epidemiology and prevent its spread. To do this, they are combining advanced imaging and sequencing technologies to study coronavirus in human intestinal…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
From fly to flower
In this composite image, visual artist Mona Kakanj assembled three different biological structures in fly larvae into a flower. The original images were taken as part of a research project by Parisa Kakanj in Maria Leptin’s group.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Blood pressure drug improves response to cancer therapy
Scientists discovered that antihypertensive agent alters the tissue characteristics of colon cancer metastases. This "stiffness" of metastases has an effect on the therapeutic success.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
New insights into epigenetic modifications
Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Genetic cut and paste at atomic resolution
Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Shining high-brilliance beams on coronavirus structure
EMBL researchers are studying COVID-19-related molecules by exposing them to high-brilliance X-ray beams. The Svergun group at EMBL Hamburg is using biological small-angle X-ray scattering (SAXS) as part of a global effort by scientists to elucidate the structural organisation of SARS-CoV-2…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Glow-in-the-dark cell skeletons
This image shows mouse embryonic fibroblasts (MEFs), their cell skeletons (green) and nuclei (blue) under a confocal microscope, photographed by Julia Hansen in the lab of Matthieu Boulard at EMBL Rome.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Re-trafficking proteins to fight Salmonella infections
Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Organelles in space
This image is a 3D-rendering of the automatic segmentation of a HeLa cell, made by Julian Hennies from the Schwab team at EMBL Heidelberg.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Enabling functional genomics studies in individual cells
Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Novel method sheds new light on tumour-suppressing RNA
Researchers from EMBL Grenoble have developed a way to visualise large RNAs in 3D using biochemical and structural biology techniques.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Distinguishing coronavirus genome mutations from inadvertent errors
EMBL scientists have performed a large-scale analysis of over 4700 SARS-CoV-2 genome sequences. They found that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Underwater butterfly
In the Leptin Group, Eva Hasel investigates the innate immune system in Japanese rice fish.
SCIENCE & TECHNOLOGY2020
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The hunt for neutralising antibodies against SARS-CoV-2
Scientists hope that a legacy of the novel coronavirus in recovered COVID-19 patients – antibodies in their blood – could lead to drugs to treat others. The Merten group at EMBL Heidelberg has pivoted its microfluidics platform to support the search for neutralising antibodies that could…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL scientists investigate rare lung disease
Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
The birth of tentacles
The image shown here, taken by Anniek Stokkermans from EMBL’s Ikmi Group, shows a larva of Nematostella vectensis.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Tracing the origins of cells
Researchers from the Sharpe group at EMBL Barcelona have published a method to track the developmental history of a cell using the gene editing tool CRISPR–Cas9, but without the need to create transgenic organisms.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding the role of our genes in SARS-CoV-2 infections
EMBL scientists will contribute to the new German COVID-19 OMICS Initiative to study the biological mechanisms contributing to coronavirus infections. EMBL group leaders Jan Korbel and Oliver Stegle, who is also affiliated with the DKFZ Heidelberg, will coordinate the set-up of IT infrastructures…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Shine like an underwater star
This image of the starlet sea anemone was taken by Petrus Steenbergen using a stereoscope.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
EMBL SPC facility supports COVID-19 projects
The Sample Preparation and Characterisation Facility (SPC) at EMBL Hamburg reopens to support scientists working on Covid-19 research. The SPC Facility is one of the best equipped facilities in Europe is therefore in high demand from external users. Re-opening the facility also allows experts at…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
DNA damage and faulty repair jointly cause mutations
DNA mutations are caused by a combination of DNA damage and repair, shows study by EMBL-EBI and collaborators.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Wings without wings
The image shown here, taken by Daniel Rios-Barrera from the Leptin Group shows the cells of the early wing tissue of the fly during larval development.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Responding to health threats posed by coronaviruses
By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Remote access to EMBL structural biology pipelines to support research on SARS-CoV-2
The Marquez Team has restarted operations at the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble. The team has developed a fully automated protein-to-structure pipeline, which can be operated remotely and provides virtual access to the facilities.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Taking a closer look at infected cells to better understand COVID-19
EMBL electron microscopy specialists collaborate with researchers from Heidelberg University Hospital to understand the changes occurring in cell structures upon SARS-CoV-2 infection.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding the influenza virus
The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Dancing chromosomes
In human cells, the genetic material is packaged into 23 different DNA molecules, the chromosomes. Each chromosome is present in two copies, one inherited from the paternal sperm, and the other from the maternal egg. During most of the cell’s life, chromosomes take the shape of long,…
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Exploring synthetic antibodies to stop coronavirus
Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Helping researchers identify host proteins used by coronavirus
EMBL scientists working in the groups of Matthias Hentze and Wolfgang Huber have created RBPbase – a database of RNA-binding proteins – to assist the identification of proteins that interact with the SARS-CoV-2 RNA genome.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Why share data during a pandemic?
In March 2020, planes were grounded, streets went quiet, and our lives changed forever. But while the world came to a halt, many scientists were ramping up their efforts to understand the new virus.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Evolution of the eye
This Picture of the Week shows a stained cryosection of a retina – the light-sensitive part of the eye – of an ancient fish, the lamprey.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Unprecedented single-cell studies in virtual embryo
Researchers from EMBL Heidelberg have created a complete description of early embryo development, accounting for every single cell in the embryo.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL-EBI launches COVID-19 Data Portal
The new collaborative space will help scientists, public health and healthcare professionals around the world to fight the coronavirus pandemic.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Helping to scale up coronavirus testing
Scientists at EMBL Heidelberg are contributing their expertise in a community effort to develop large-scale testing methods for coronavirus. Their goal is to increase the capacity and speed of testing, which is crucial for containing the pandemic.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Identifying how potential COVID-19 drugs work
EMBL researchers are studying how drugs that have shown good results against COVID-19 work in living cells
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Producing proteins for coronavirus research
The Protein Expression and Purification Core Facility at EMBL Heidelberg will produce proteins for several coronavirus-related research projects, to assist the development of new strategies to fight the virus.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Gazing at healing wounds
What may look like a branch of a tree with the first flower buds emerging after winter are, in fact, tracheal cells of a fruit fly larva and their nuclei.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
How chromosome structure influences development
EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Exciting science!
EMBL is all about exciting science, through which we aim to achieve a fundamental understanding of biological processes.
SCIENCE & TECHNOLOGY2020
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Tissue dynamics provide clues to human disease
EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and ribs
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding brain tumours in children
The causes of 40 percent of all cases of certain medulloblastoma – dangerous brain tumours affecting children – are hereditary. These are the findings of a recent genetic analysis carried out by scientists from EMBL and numerous colleagues around the world.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Artistic life sciences
Paola Bertucci, from the Arendt Group at EMBL Heidelberg, studies the evolution of Platynereis dumerilii – a species of annelid polychaete worm.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
EMBL-EBI leads International collaboration to share COVID-19 research data
EMBL-EBI set to launch European COVID-19 Data Platform to help store, share, and analyse research data linked to the COVID-19 pandemic.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Wrapped in purple
The medaka shown in this Picture of the Week was captured by Eva Hasel, a postdoc in the Leptin group at EMBL Heidelberg.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
New insights into gene regulation
EMBL researchers investigate the role of a histone protein in regulating gene expression
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Finding your way around Platynereis dumerilii
EMBL researchers combine multiple datasets to develop expandable atlas of an entire animal
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Accidental beauty
In the Trivedi Group at EMBL Barcelona, Krisztina Arató and Jia Le Lim study the early development of zebrafish embryos.
SCIENCE & TECHNOLOGY2020
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Mapping space inside the cell
In this image, Julian Hennies from the Schwab Team has reconstructed the 3D structure of a human cell's organelles.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
Breathe in, breathe out
This image shows the tracheal system of a live fruit fly larva. Daniel Rios from the Leptin Group and Dimitri Kromm from the Hufnagel Group used this advanced microscope to investigate the dynamics of tracheal cells during development.
SCIENCE & TECHNOLOGY2020
picture-of-the-weekscience-technology
New technique for studying living fly larvae
This technique provides a simple but effective way to study the functions of organs in living animals
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How females shut off their second X chromosome
Scientists provide important new insights into the molecular basis of X-inactivation
SCIENCE & TECHNOLOGY2020
sciencescience-technology
The Pan-Cancer project
EMBL co-leads most comprehensive study of genetic causes of cancer
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Protecting data in the cloud
Cloud computing offers unprecedented opportunities for global-scale research collaborations. It also presents a unique set of challenges in terms of data protection and the ethics of data sharing.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Characterising RNA alterations in cancer
The largest and most comprehensive catalogue of cancer-specific RNA alterations reveals new insights into the cancer genome.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Cancer mutations occur decades before diagnosis
Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Analysis of human genomes in the cloud
Scientists from EMBL present a tool for large-scale analysis of genomic data with cloud computing. Main advantages of the new tool, called Butler, are continuous system monitoring and its ability to self-heal in case of failure, allowing for 43% more efficient data processing than previous…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Studying DNA rearrangement to understand cancer
Using the dataset from the Pan-Cancer project, scientists has developed methods to group, classify, and describe large rearrangements of the genome that are a key driver of cancer.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Scientists identify new genetic drivers of cancer
Analysis of whole cancer genomes gives key insights into the role of the non-coding genome in cancer
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Chromothripsis in human cancer
Researchers at Harvard Medical School and EMBL-EBI have carried out the largest analysis across cancer types of the newly discovered mutational phenomenon chromothripsis.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Finding genetic cancer risks
Using the data from the Pan-Cancer project EMBL scientists describe how our genetic background influences cancer development.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Pinpointing rare disease mutations
New resource that categorises genes essential for supporting life could be used to identify rare disease mutations
SCIENCE & TECHNOLOGY2020
sciencescience-technology
From cosmetics to blood cells
Morgan Oatley and her colleagues in Christophe Lancrin’s group investigated how haematopoietic stem cells emerge from the endothelium in developing mouse embryos.
SCIENCE & TECHNOLOGY2020
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Injured lung
Muzamil Majid Khan, a postdoc in the Pepperkok team at EMBL Heidelberg, studied the piece of tissue visible in this image.
SCIENCE & TECHNOLOGY2020
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How transcription factors work together
EMBL researchers have developed a method to observe interactions between transcription factors
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Antibody engineering for therapy and diagnosis
The new EMBL spinoff company Araxa Biosciences GmbH aims to set new standards for the development of antibody-based therapeutics and diagnostics
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
Ageing and disease
Dame Janet Thornton presents the 2019 EMBL Insight Lecture: Ageing and disease – what is the link?
SCIENCE & TECHNOLOGY2020
eventsscience-technology
Look at these curves!
The image shown here is a 3D-rendering created by Julian Hennies from the Schwab team.
SCIENCE & TECHNOLOGY2020
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Melting reveals drug targets in a living organism
EMBL scientists identify drug targets in blood and organs
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Ring of fire
This image has been composed from thousands of individual super-resolution microscopy images. It was created by Markus Mund in the Ries Group.
SCIENCE & TECHNOLOGY2020
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Skittles for science
What might also be an artistic representation of a scattered bowl of Skittles is actually a 3D reconstruction of a high-pressure frozen HeLa cell.
SCIENCE & TECHNOLOGY2020
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Tumour takeover
Breast cancer is the second leading cause of cancer-related deaths in women. It is so deadly because tumours often return after successful cancer treatment. This recurrence is caused by individual dormant cancer cells remaining inside the breast. These cells can develop into active cancer cells…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
Launching proteins
What looks like a photo-series of an explosive eruption are actually uptaking proteins, captured by Markus Mund from the Ries Group at EMBL Heidelberg. The images were made in an attempt to learn how the different proteins that take up molecules into the cells via endocytosis – the cellular…
SCIENCE & TECHNOLOGY2019
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EMBL co-develops new method that could facilitate cancer diagnosis
Researchers have developed a cheaper and faster method to check for genetic differences in individual cells
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Innovative method delivers new insights into the stem cell microenvironment
Researchers have developed new methods to reveal the 3D-organisation of bone marrow at a single cell level
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A classification tool for transcription factors
The software diffTF quantifies activity of transcription factors and predicts their mode of action
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Reshaping our DNA
DNA is present in each cell of our body. If all the DNA from one human cell was removed and aligned in a single strand, it would in theory add up to a total length of about two metres. In order to fit into the nucleus of a cell, DNA has to be compressed by […]
SCIENCE & TECHNOLOGY2019
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Machine learning finds critical phosphosites
Resource has implications for disease research
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Birth of two HeLa stars
This picture of the week, taken by Arina Rybina in the Ellenberg group at EMBL Heidelberg, shows a high-resolution 3D microscopy image of living human cells: HeLa cells. In this fascinating fluorescing microspace, two newly formed daughter nuclei are captured to study the assembly of nuclear pore…
SCIENCE & TECHNOLOGY2019
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Understanding a key player in melanoma
A new paper describes a unique mechanism of partner selectivity in transcription factors.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Skin mosaic
This beautiful mosaic of mostly hexagonal cells is the outer skin layer of a zebrafish larva as seen under a microscope. Each skin cell exhibits a unique pattern of actin ridges. Actin is a family of globular multifunctional proteins found in almost all eukaryotic cells. Actin forms microfilaments,…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
Neural pathways
Exploring the diverse routes by which EMBL scientists are driving forward neurobiology
SCIENCE & TECHNOLOGY2019
sciencescience-technology
EMBL makes insulin visible
The hormone insulin helps to remove sugar from the blood after a meal. This is important, as in the long term high blood sugar levels damage our bodies. Diabetes of type 1 or type 2 is a direct consequence of a failure to produce sufficient insulin or to release it from the cells in which […]
SCIENCE & TECHNOLOGY2019
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From cell to mouse – how tissues differentiate
Shedding light on the mechanisms that control the fate of embryonic cells
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Formation of a brain
The brain is the most complex organ in the human body. Yet despite it being the organ that makes us conscious beings – and despite the fact that researchers have been studying it for generations – it’s still a constant source of surprise. To help lift the veil on some of its mystery, Lina…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
Photo-micropatterning advances structural cell biology
A new technique in cryo-EM
SCIENCE & TECHNOLOGY2019
sciencescience-technology
New perspectives on nuclear pores
EMBL researchers have published two new studies involving the nuclear pore complex
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A mix of sensations
Traditionally, we talk about having five senses: sight, hearing, taste, smell and touch. In reality, our bodies are capable of much more. Sitting right under our skin are a variety of sensory neurons, which are specialised in detecting light touch, pain, temperature, itch or the body’s position.…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
EMBL spins the Sleeping Beauty transposase
New possibilities for gene therapies
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Inside out, and grub becomes fly
The three bluish blobs shown in the top right corner of this image may not resemble the sphere of noodles that is the human brain, but they are still essential – at least for the fruit fly. This Picture of the Week shows the brain lobes of Drosophila. It’s an insect so tiny and so […]
SCIENCE & TECHNOLOGY2019
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Engineering bacteria to fight diabetes
EMBL’s Genomics Core Facility supports students participating in the annual iGEM competition.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A perfect model
Is it a fungus or a strange plant? Actually it’s the larval form of Platynereis – a group of marine ringed worms. Scientists have been using them in their studies for the past 70 years, and they are among the preferred lab organisms. They are easy to keep in the lab, and under temperature and…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
A tool to monitor tuberculosis
Funding awarded to EMBL-EBI for tuberculosis monitoring tool
SCIENCE & TECHNOLOGY2019
sciencescience-technology
The zebrafish earned its stripes
Despite missing the characteristic stripes one would expect from a zebra – or a zebrafish – the fractals in this Picture of the Week show a zebrafish; or at least some cells in a zebrafish embryo, a few hours after fertilisation. Zebrafish are not only popular aquarium fish, they are also an…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
The evolution of the eye
Model organisms are species that are studied extensively to understand particular biological phenomena and processes, with the expectation that discoveries made in the model organism will provide insight into the workings of other organisms. The small marine ringed worm Platynereis dumerilii gained…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
A giant called dumpy
Fruit flies have something that we don’t have: they produce a protein called dumpy. This protein is the largest created by insects, and is comparable in size to the largest human protein – titin. While titin is vital for our muscle function, dumpy connects the soft cells of the insect’s…
SCIENCE & TECHNOLOGY2019
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Happy hour for time-resolved crystallography
Researchers from Hamburg simplify time-resolved X-ray crystallography
SCIENCE & TECHNOLOGY2019
sciencescience-technology
B cells linked to immunotherapy
Immunotherapy: the role of B cells
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Tracking the beginning of life
All mammalian life starts with the fusion of egg and sperm, resulting in the creation of a single cell called a zygote. This develops into an embryo through a series of cell divisions, in which the number of cells doubles at each step. Todays’ Picture of the Week was taken by Manuel Eguren of the…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
A robust allrounder
This gorgeous image of a stained adult marine worm was created by former EMBL postdoc Hernando Martinez using structured microscopy. The worm itself was captured during plankton extraction off the coast of Sweden. There are over 10 000 species of these swimming worms, and they have adapted to every…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
MEG3 kissing loops essential for tumour suppression
MEG3 adopts a complex three-dimensional structure to fulfil its tumour suppressor function.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
When life takes shape
Today’s picture of the week is not only a colourful one, it is also a snapshot of the vast number of shapes that the cells inside an animal body can adopt. How this variety comes about is investigated in the Leptin group at EMBL Heidelberg. To understand the shapes of the cells in fruit fly…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
Understanding molecular mechanisms of ageing
Understanding how ageing works at a molecular level
SCIENCE & TECHNOLOGY2019
sciencescience-technology
The muscles that regulate blood pressure
Low blood pressure (hypotension) or high blood pressure (hypertension) are risk factors for many diseases and affect more than 20% of the global population. How blood pressure is regulated is part of the research done in the Heppenstall group at EMBL Rome. In today’s Picture of the…
SCIENCE & TECHNOLOGY2019
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Transcriptional hubs confer phenotypic robustness
Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Muscle games
Every single moment of our life we use our muscles – most of the time without even thinking about it. Some muscles, like our heart, we cannot even control at all. How our brain communicates with our muscles is still not fully understood. The communication between our brain and our skeletal…
SCIENCE & TECHNOLOGY2019
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Toxin responsible for Legionella growth identified
SidJ enforces a unique modification on human proteins and helps legionella grow.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
First results from CSSB
EMBL scientists collaborate to develop new protocol for screening membrane protein stability
SCIENCE & TECHNOLOGY2019
sciencescience-technology
The birth of new cells – when two become four
This colourful picture, taken by EMBL postdoc Arina Rybina using a confocal fluorescence microscope, shows human cells in the process of cell division. Eventually, each mother cell brings into existence two identical daughter cells. To visualise the process by light microscopy, different cell…
SCIENCE & TECHNOLOGY2019
picture-of-the-weekscience-technology
Rearranging chromosomes
Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A tRNA modifier at work
Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.
SCIENCE & TECHNOLOGY2019
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Programming: language
How computer processing of human language is harnessed by EMBL scientists
SCIENCE & TECHNOLOGY2019
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Wielding the genetic scissors
What CRISPR may bring for the future of biology, and how it is used at EMBL
SCIENCE & TECHNOLOGY2019
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Actin crosslinking plays key role in tissue morphogenesis
New insights into mechanisms behind embryonic development
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A new home for biological images
The BioImage Archive - EMBL-EBI's first dedicated imaging data resource
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Cell duplication
What looks like a pair of scary alien eyes is actually the final stage in the duplication of a cell. Cell duplication is preceded by a process called mitosis, in which the replicated chromosomes are separated into two new nuclei. Mitosis is the prerequisite for a cell to divide into two identical…
SCIENCE & TECHNOLOGY2019
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How coding opens up scientific data
The increasing importance of code in the biological sciences
SCIENCE & TECHNOLOGY2019
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Life with the endangered kākāpō
Using genomics to help endangered species
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Intact chromosomes during cell division
The mystery of how condensin maintains the integrity of the genome during cell division.
SCIENCE & TECHNOLOGY2019
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Hydraulic force shapes mammalian embryos
Uncovering new role of fluid pressure in controlling embryo size and cell fate
SCIENCE & TECHNOLOGY2019
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Paving the way for new flu drugs
Snapshots of the flu virus replication machine in action
SCIENCE & TECHNOLOGY2019
sciencescience-technology
From fruit flies to cancer treatment
This image – resembling a network of rivers and canals – actually shows the tracheal tip cell of a fruit fly. Fruit flies are heavily used in research and they are a common model organism in developmental biology. Researchers at EMBL use the larvae of fruit flies to study tracheal cell…
SCIENCE & TECHNOLOGY2019
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The origins of plastic pollution at sea
Tara Ocean Foundation launches the exploration of 10 European rivers
SCIENCE & TECHNOLOGY2019
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Breaking the bottleneck in imaging data collection
Scientists develop software tools for automated acquisition of electron microscopy data
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Walking on DNA
EMBL is a world-leading organisation for life science research. Its scientists work in diverse research fields spanning the whole of molecular biology. While the molecules the researchers are working on are often microscopic and impossible to see with the naked eye, one research topic clearly…
SCIENCE & TECHNOLOGY2019
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New 3D microscope
A newly developed 3D microscope visualises fast biological processes better than ever.
SCIENCE & TECHNOLOGY2019
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The Arctic Ocean: reservoir of marine viruses
Results from the Tara Oceans expedition reveal the Arctic Ocean as a cradle of viral biodiversity
SCIENCE & TECHNOLOGY2019
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Sex and diet affect proteotype
EMBL scientists have discovered that the proteome is substantially affected by both sex and diet
SCIENCE & TECHNOLOGY2019
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Catalogue of structural variants
Thorough characterisation of structural variants in human genomes
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Prioritising cancer drug targets using CRISPR
Large CRISPR screen prioritises hundreds of promising genes for personalised cancer treatment
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Global microbial signatures for colorectal cancer
Colorectal cancer characterised by consistent changes in gut bacteria across continents, cultures and diets
SCIENCE & TECHNOLOGY2019
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Designer organelles bring new functionalities into cells
EMBL scientists create membraneless organelle to build proteins in living cell
SCIENCE & TECHNOLOGY2019
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ATP affects proteome-wide solubility
Scientists develop technology to measure how ATP concentration affects protein solubility in cells
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Welcome: Sagar Bhogaraju
New group leader at EMBL Grenoble is investigating the cellular role of melanoma antigens
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Many gut microbes may originate in the mouth
Many microbes traverse the oral-gut barrier
SCIENCE & TECHNOLOGY2019
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Understanding early embryo development in mice
How organs form in a mouse embryo
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Cell death trigger in tuberculosis bacteria
Suicide system in tuberculosis bacteria might hold key to treatment
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Role reversal: RNA controls protein function
EMBL scientists identify RNA regulating protein behaviour in switch of normal roles
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Almost 2000 unknown gut bacteria discovered
Researchers identify novel gut bacteria species and call for more data from beyond Europe and North America
SCIENCE & TECHNOLOGY2019
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More than 100 new gut bacteria discovered in human microbiome
A new database of bacteria in the human microbiome is the most comprehensive to date.
SCIENCE & TECHNOLOGY2019
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The web meets genomics: a DNA search engine for microbes
New search engine allows researchers to identify antibiotic resistance genes or mutations in real time
SCIENCE & TECHNOLOGY2019
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New method to study gene expression in yeast cells
Scientists develop high-throughput yeast single-cell RNA sequencing method
SCIENCE & TECHNOLOGY2019
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Structure of prodrug-transporter complex revealed
Scientists develop structural model that could help in the development of drugs with increased absorption rates
SCIENCE & TECHNOLOGY2019
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Facilitating transcontinental human data exchange
Federated data sharing will now be possible on an unprecedented scale
SCIENCE & TECHNOLOGY2019
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Hundreds of tiny robots grow bio-inspired shapes
Scientists build self-organising features into robot swarms to study shape formation
SCIENCE & TECHNOLOGY2018
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Using light to stop itch
EMBL researchers have found a way to stop itch with light in mice
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Model to predict prostate cancer progress
Cancer researchers have developed a computer model to predict the course of disease for prostate cancer
SCIENCE & TECHNOLOGY2018
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New ways to look at protein-RNA networks
Researchers develop new method to analyse the entire protein-RNA network of the cell
SCIENCE & TECHNOLOGY2018
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Discovering new enzymes just got easier
EMBL-EBI industry case study: Biocatalysts
SCIENCE & TECHNOLOGY2018
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Translating blue-sky research into the clinic
What does it take to create a vaccine or improve cancer therapies?
LAB MATTERSSCIENCE & TECHNOLOGY2018
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Algorithm identifies gene–environment relationships
New algorithm will enhance understanding of relationship between genotype and environmental factors
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Molecular and behavioural effects of SETD5 mutation
Scientists uncover effects of mutation that can cause autism and intellectual disability
SCIENCE & TECHNOLOGY2018
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An in silico hope for biology: machine learning
How EMBL scientists are using machine learning to advance biology
LAB MATTERSSCIENCE & TECHNOLOGY2018
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Controlling organ growth with light
The De Renzis group investigated invagination, the first step of organ development in embryos.
SCIENCE & TECHNOLOGY2018
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In the flesh: translating 2D scans into 3D prints
Translating 2D hospital scans into 3D prints is informing patients and aiding surgeons
SCIENCE & TECHNOLOGY2018
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Genomes of all known UK species to be sequenced
Genomes of 66,000 UK species to be sequenced in global effort to sequence all known eukaryotic species
SCIENCE & TECHNOLOGY2018
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New insights into the regulation of haemostasis
EMBL scientists investigate the structure of a key protein involved in blood clotting
SCIENCE & TECHNOLOGY2018
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Catching up on protein dynamics
The Hentze Lab enhanced a RNA-interactome capture technique to pave the way towards medical progress
SCIENCE & TECHNOLOGY2018
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Time-resolved X-ray crystallography simplified
Speeding up time-resolved X-ray crystallography with EMBL beamline P14
SCIENCE & TECHNOLOGY2018
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A worm’s sense of the world
EMBL researchers discover that four organs in a marine worm’s head can sense different chemicals
SCIENCE & TECHNOLOGY2018
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More effective insulin thanks to first 3D image
New study reveals how to make therapeutic insulins more effective than they currently are
SCIENCE & TECHNOLOGY2018
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Exploring cell identity by mapping genetic networks
ERC grantees Wolfgang Huber and Oliver Stegle share their vision for the next 10 years
SCIENCE & TECHNOLOGY2018
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ARP/wARP 8.0 released
Researchers at EMBL Hamburg have released the next generation of their ARP/wARP software
LAB MATTERSSCIENCE & TECHNOLOGY2018
lab-mattersscience-technology
Deleting genes to study how germ cells are born
How embryonic stem cells develop into the germ line
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Transcription factors controlled by DNA sequence
EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Ageing is visible in the way cells use glucose
Researchers from EMBL and Heidelberg University unveil the molecular mechanisms of ageing
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Looking for life using geobiology
Meet the organisers of EMBO’s first course on molecular geobiology
SCIENCE & TECHNOLOGY2018
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Solving the structure of retromer
Retromer’s 3D structure improves understanding of cellular sorting and packaging
SCIENCE & TECHNOLOGY2018
sciencescience-technology
X-rays reveal surprising shape of scaffolding protein
X-ray experiments show that scaffolding protein PDZK1 has a L-shaped conformation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
First interactive model of human cell division
Real-time tracking of proteins during mitosis is now possible using a 4D computer model
SCIENCE & TECHNOLOGY2018
sciencescience-technology
PhenoMeNal: an online portal for metabolomics
Complex metabolomics analyses in the cloud
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Cohesin: a glue for DNA
EMBL scientists discover how a component of the cohesin ring binds DNA
SCIENCE & TECHNOLOGY2018
sciencescience-technology
New approach for testing cancer drug response
Large-scale systematic analysis explores how inherited genome affects drug response of cancer cells
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Understanding soil through its microbiome
First global survey of soil genomics reveals a war between fungi and bacteria
SCIENCE & TECHNOLOGY2018
sciencescience-technology
The proteins behind hungry cells
EMBL researchers visualise the proteins needed to capture molecules and bring them into a cell
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Europe PMC now indexes preprints
Europe PMC adds preprints to its search
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Parental chromosomes kept apart during first division
Mammalian life begins differently than we thought
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Maternal bacteria persistent in newborns
Scientists show how bacteria and other microorganisms are passed on from mother to child
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Leukaemia roots detectable years before diagnosis
Acute myloid leukaemia risk could be detected years before diagnosis
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Melting bacteria to decipher antibiotic resistance
EMBL scientists investigate how bacteria melt to study their reaction to drugs
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Combining antibiotics changes their effectiveness
Combining antibiotics with each other, non-antibiotic drugs or food additives can alter their effectiveness
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Algal nuclear pore complex revealed
EMBL scientists reveal NPC architecture of algae
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Flu’s response to new drug explored
EMBL scientists investigate how influenza virus responds to new drug treatment
SCIENCE & TECHNOLOGY2018
sciencescience-technology
New way to isolate DNA- and RNA-protein complexes
EMBL researchers develop method that simplifies the isolation of DNA- and RNA- protein complexes
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Miniature testing of drug pairs on tumour biopsies
Combinations of cancer drugs can be quickly and cheaply tested using a novel microfluidic device
SCIENCE & TECHNOLOGY2018
sciencescience-technology
New insights into Turing patterns
EMBL scientists extend Turing’s theory to help understand how biological patterns are created
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Personalised medicine: one data type is not enough
New computational method uses multi-omics analysis for personalised medicine
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Constructing new tissue shapes with light
EMBL researchers guide the shape of cells and tissues with optogenetics
SCIENCE & TECHNOLOGY2018
sciencescience-technology
How wild species may benefit from mouse genetic data
Of mice and gorillas: using mouse data for conservation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Reconstructing 3D shapes from unmeasurable data
Scientists at EMBL Hamburg determine shapes of intermediate states in dynamic biological systems
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Exploring genetic variation
EMBL group leader Jan Korbel reflects on his scientific origins and current research
SCIENCE & TECHNOLOGY2018
sciencescience-technology
New risk factors for rare childhood cancer
Researchers identify genes that can cause brain tumours in children and other cancers later in life
SCIENCE & TECHNOLOGY2018
sciencescience-technology
CRISPR: from clipping scissors to word processor
New platform transforms CRISPR gene editor into precision tool
SCIENCE & TECHNOLOGY