EMBL Events

2 October - 6 October 2023

Structural bioinformatics

Sophie Spencer

This course provides a guide to the commonly used methods and tools in structural bioinformatics to analyse and interpret experimentally determined and AI predicted macromolecular structure data Structural biology determining the three dimensional shapes of biomacromolecules and their complexes can tell us a lot about how these molecules function and the roles they play within a cell Data derived from structure determination experiments and Artificial Intelligence AI assisted structure prediction enables life science researchers to address a wide variety of questions This course explores bioinformatics data resources and tools for the investigation analysis and interpretation of both experimentally determined and predicted biomacromolecular structures It will focus on how best to analyse and interpret available structural data to gain useful information given specific research contexts The course content will also cover predicting function and exploring interactions with other macromolecules Successful participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course... This course provides a guide to the commonly used methods and tools in structural bioinformatics to analyse and interpret experimentally determined and AI-predicted macromolecular structure data. Structural biology, determining the three-dimensional shapes of biomacromolecules and their complexes, can tell us a lot about how these molecules function and the roles they play within a cell. Data derived from structure determination experiments and Artificial Intelligence (AI)-assisted structure prediction enables life-science researchers to address a wide variety of questions.   This course explores bioinformatics data resources and tools for the investigation, analysis, and interpretation of both experimentally determined and predicted biomacromolecular structures. It will focus on how best to analyse and interpret available structural data to gain useful information given...

4 October - 7 October 2023

Seeing is believing: imaging the molecular processes of life

Jan Ellenberg, Jennifer Lippincott-Schwartz, Satyajit Mayor, Atsushi Miyawaki

The symposium will bring together the leading developers of imaging methods with cutting edge applications that illustrate how imaging can answer biological questions We will emphasize methods that can capture the dynamics of life spanning the whole range from molecular resolution to imaging of whole organisms From its beginning in 2011 Seeing is Believing has embraced novel imaging technologies that open new windows for biological discovery including single molecule and super resolution light sheet and correlative light electron microscopy... OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kitPre-conference workshopsLunch workshops Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Symposium overview The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease.The symposium will bring together the leading developers of imaging methods with cutting-edge applications that illustrate how imaging can answer biological questions. We will emphasize methods that...

4 October 2023

Studying genes and genomes with Ensembl genome browser

The Ensembl genome browser provides data on genes variants comparative genomics and gene regulation for over 300 species Its sister project Ensembl Genomes www ensemblgenomes org consists of five sub portals bacteria fungi protists plants and invertebrate metazoa which contain data for over 2 000 eukaryotic including wheat barley tomato and brassicas and over 30 000 prokaryotic genomes This webinar will provide the participants with an introduction on how to use the Ensembl genome browser navigate the website and export data... The Ensembl genome browser provides data on genes, variants, comparative genomics, and gene regulation for over 300 species. Its sister project, Ensembl Genomes (www.ensemblgenomes.org), consists of five sub-portals (bacteria, fungi, protists, plants, and invertebrate metazoa) which contain data for over 2,000 eukaryotic (including wheat, barley, tomato and brassicas) and over 30,000 prokaryotic genomes. This webinar will provide the participants with an introduction on how to use the Ensembl genome browser, navigate the website, and export data.

5 October 2023

Poster winners, PerMedCoE Summer School 2023

Viviam Bermúdez, Marco Fariñas, Malvina Marku

This special edition of the PerMedCoE webinar series features speakers who were awarded poster prizes at the PerMedCoE Summer School 2023 Find out more about our speakers and their research Towards Tailored Cancer Therapies Robust platform for drug testing in patient specific Boolean models Viviam Berm dezComputational modelling of High Grade Serous Ovarian Cancer HGSOC Marco Fari asDissecting cellular communication in the tumour microenvironment through multiscale dynamical modelling Malvina MarkuAbout the speakerViviam Berm dez is a PhD candidate at the Norwegian University of Science and Technology specialising in Boolean models Her academic journey began in general biology back in her home country Venezuela at Sim n Bol var University Then she hopped over to Norway for a one year student exchange where she unexpectedly found herself staying longer to complete a master s degree in molecular cell biology diving deep into systems biology and cell modelling Now in her Computational Cancer Biology PhD she combines machine learning and modelling to address complex challenges of precision medicine Beyond her coding skills she also has green fingers so she finds peace caring for her plants during her free time Looking ahead she aspires to contribute to the field of precision medicine through her PhD project and continue exploring the fascinating world of digital twins without forgetting the ethical side of things Marco Fari as originally from Ponferrada in north western Spain is an enthusiastic nature lover who enjoys spending free time outdoors His academic journey began with a Bachelor s degree in Biology at the Complutense University of Madrid Following his interest for cellular and molecular biology he moved to Trondheim Norway where he pursued a Master s degree at the Norwegian University of Science and Technology NTNU During this period Marco did his thesis focusing on Boolean modelling of macrophage polarisation and its relevance to acute COVID 19 This research was conducted under the guidance of Martin Kuiper within the DrugLogics group Following the completion of the Master s program Marco moved to Barcelona and joined Marta Cascante s research group at Barcelona University There he delved into the intricate metabolic alterations triggered by SARS CoV 2 infection In his latest pursuit Marco returned to Trondheim to start his PhD journey at NTNU under the supervision of Kaisa Lehti His research leverages Boolean modelling to explore the dynamics of the tumour microenvironment and its influence on the aggressiveness of high grade serous ovarian cancer Malvina Marku studied her undergraduate degree in Physics at the University of Tirana Albania where she pursued her MSci project in the field of Nonlinear Dynamics studying the qualitatively universal behaviour of recursive systems As a PhD student on Computational Physics at the University of Tirana her PhD thesis focused on mathematical modelling of regulatory networks and inference methods of network reaction rates She joined Pancaldi s lab at the Cancer Research Center of Toulouse as a postdoc where she is currently working on multi scale dynamical modelling of the tumour microenvironment The research is focused on Chronic Lymphocytic Leukaemia CLL microenvironment and the crucial role of the cancer cell immune cell interaction in defining the cancer cell survival Her main interest is in applying dynamical modelling and networks theory to study the dynamics and emerging behaviour of complex biological systems and to gain a deeper understanding of systems evolution from the molecular network perspective She is interested in using computational models that are able to capture emerging biological behaviour and evolving patterns in spatially structured tumours for enabling more accurate and clinically relevant predictions regarding disease course and treatment outcome... This special edition of the PerMedCoE webinar series features speakers who were awarded poster prizes at the PerMedCoE Summer School 2023. Find out more about our speakers and their research.Towards Tailored Cancer Therapies: Robust platform for drug testing in patient-specific Boolean models - Viviam BermúdezComputational modelling of High Grade Serous Ovarian Cancer (HGSOC) - Marco FariñasDissecting cellular communication in the tumour microenvironment through multiscale dynamical modelling - Malvina MarkuAbout the speakerViviam Bermúdez is a PhD candidate at the Norwegian University of Science and Technology, specialising in Boolean models. Her academic journey began in general biology back in her home country, Venezuela, at Simón Bolívar University. Then, she hopped over to Norway for a one-year student exchange, where she unexpectedly found herself staying longer to complete a...

9 October - 13 October 2023

Metagenomics bioinformatics at MGnify

Meredith Willmott

Overview Learn about the tools processes and analysis approaches used by MGnify in the field of genome resolved metagenomics This course will cover the use of publicly available resources to manage share analyse and interpret metagenomics data focussing primarily on the assembly based approaches used in MGnify analysis The delivered content will involve participants learning via live lectures and presentations followed by live Q As with the trainers Practical experience will be developed in group activities and in computational exercises run using containerised tools on our training infrastructure... Overview Learn about the tools, processes, and analysis approaches used by MGnify in the field of genome-resolved metagenomics. This course will cover the use of publicly available resources to manage, share, analyse, and interpret metagenomics data, focussing primarily on the assembly-based approaches used in MGnify analysis. The delivered content will involve participants learning via live lectures and presentations, followed by live Q&As with the trainers. Practical experience will be developed in group activities and in computational exercises run using containerised tools on our training infrastructure.

9 October - 13 October 2023

Liquid biopsies

Anders Ståhlberg, Karin Sundfeldt

OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course Overview There is an increasing interest and need to analyse biomarkers in liquid biopsies including basic research and clinical applications Liquid biopsies have several advantages including being... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course Overview There is an increasing interest and need to analyse biomarkers in liquid biopsies, including basic research and clinical applications. Liquid biopsies have several advantages including being minimally invasive, allowing repeated sampling and sampling is often clinical routine. This course will provide an overview of the several techniques to detect and analyse liquid biopsy-based analytes such as circulating tumour cells, cell-free tumor-DNA (ctDNA), miRNA, extracellular vesicles, mRNA, carbohydrates and proteins. Participants will be introduced to all aspects ranging from proper sampling through analyte analysis and final data analysis. Experimentally, we will demonstrate ultrasensitive ctDNA...

10 October - 12 October 2023

Open Virtual Ensembl Browser Workshop

Benjamin Moore

Work with the Ensembl Outreach team to get to grips with the Ensembl browser accessing gene variation comparative genomics and regulation data and mine these data with BioMart... Work with the Ensembl Outreach team to get to grips with the Ensembl browser, accessing gene, variation, comparative genomics and regulation data, and mine these data with BioMart.

11 October - 14 October 2023

The non-coding genome

Marc Bühler, Anna Eulálio, Joshua Mendell, Gisela Storz, Igor Ulitsky

This symposium will explore the diverse dynamic and multifaceted roles of RNA across a spectrum of cellular processes It will provide an interdisciplinary discussion of the roles of non coding RNAs in both prokaryotes and eukaryotes with the aim of enhancing our understanding of gene regulation and function... OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Symposium overview Over the past two decades, advances in transcriptomic methods have led to the discovery of a very rich and diverse set of RNA transcripts, short and long, that serve as regulators rather than templates for protein production. Many of these transcribed elements are encoded in noncoding regions of the genome with other regulatory and structural DNA elements of known and unknown functions. While the catalogs of such elements are very rich, and an ever-increasing number are implicated in almost every known biological process, there are still many key open questions. Often these important problems are tackled and discussed within different sub-communities, including the mature fields of microRNAs (miRNAs) and...

11 October 2023

Accessing and interpreting predicted protein structures from AlphaFold database

AlphaFold database AlphaFold DB provides open access to over 200 million protein structure predictions to accelerate scientific research This webinar aims to provide a comprehensive introduction to AlphaFold DB Participants will gain a clear understanding of the fundamental concepts principles and functionalities of the database They will learn how to access and evaluate predicted protein structures explore the underlying technologies and algorithms used in AlphaFold and identify the potential applications of AlphaFold DB in their research... AlphaFold database (AlphaFold DB) provides open access to over 200 million protein structure predictions to accelerate scientific research. This webinar aims to provide a comprehensive introduction to AlphaFold DB. Participants will gain a clear understanding of the fundamental concepts, principles, and functionalities of the database. They will learn how to access and evaluate predicted protein structures, explore the underlying technologies and algorithms used in AlphaFold, and identify the potential applications of AlphaFold DB in their research

17 October - 19 October 2023

Open Virtual Ensembl REST API Workshop

Louisse Paola Mirabueno

Work with Ensembl to master the Ensembl REST API and flexibly access genome wide data such as genes variants regulatory features homologues and alignments... Work with Ensembl to master the Ensembl REST API and flexibly access genome-wide data, such as genes, variants, regulatory features, homologues and alignments.

18 October - 21 October 2023

Organoids: modelling organ development and disease in 3D culture

Meritxell Huch, Karl R. Koehler, Madeline Lancaster, Esther Schnapp

OverviewSpeakersProgrammePractical informatonSponsorsAboutMedia kitPre conference workshops Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview The ability to grow human tissues from stem cells in 3D culture has the potential to revolutionise the drug discovery process and regenerative medicine Building on a long tradition... OverviewSpeakersProgrammePractical informatonSponsorsAboutMedia kitPre-conference workshops Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Symposium overview The ability to grow human tissues from stem cells in 3D culture has the potential to revolutionise the drug discovery process and regenerative medicine. Building on a long tradition of cell and developmental biology knowledge, organoids resembling a variety of human tissues have been generated. This conference will bring together the leading researchers in this field to establish a new research community and reveal parallels between various tissue models. The aim of this meeting is to bring together researchers from different fields to enhance our understanding of how organoids can be formed and maintained, how they can be used to study disease and how we might eventually use them...

18 October 2023

Finding and interpreting protein structure and function data using PDBe-KB

Proteins are the workhorses of the cell responsible for most biological functions Though we can group related proteins through sequence similarity it is the 3 dimensional structure of these proteins that determines the functions of these molecules of life Therefore knowledge of protein structure and its relation to additional biological context can help us create a more complete understanding of how a protein works PDBe KB https pdbe kb org is an open collaborative data resource which aims to support the access and integration of structural biology data helping users to easily generate biological insights The Aggregated Views of Proteins provided through PDBe KB provide a unique way to display all the relevant structure and function data for a specific protein in one place This allows us to determine trends across these structures including common binding and interaction sites and identification of different conformations of the protein This webinar will give an introduction to the PDBe KB Aggregated Views of Proteins and how they can be used to access and interpret structure and function data... Proteins are the workhorses of the cell, responsible for most biological functions. Though we can group related proteins through sequence similarity, it is the 3-dimensional structure of these proteins that determines the functions of these molecules of life. Therefore, knowledge of protein structure, and its relation to additional biological context, can help us create a more complete understanding of how a protein works. PDBe-KB (https://pdbe-kb.org) is an open, collaborative data resource, which aims to support the access and integration of structural biology data helping users to easily generate biological insights. The Aggregated Views of Proteins, provided through PDBe-KB, provide a unique way to display all the relevant structure and function data for a specific protein, in one place. This allows us to determine trends across these structures, including common binding and...

22 October - 27 October 2023

FISHing for RNAs: classical to single molecule approaches

Monica Ballarino, Imre Gaspar, Emerald Perlas, Elisabeth Zielonka

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview Over the past decades it became evident that the specific amount and localisation of an RNA transcript are important to understand the biological function of its non coding gene Whereby state of the art in situ hybridisation ISH technologies are key to visualise these RNAs in a given... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview Over the past decades, it became evident that the specific amount and localisation of an RNA transcript are important to understand the biological function of its (non-) coding gene. Whereby state-of-the-art in situ hybridisation (ISH) technologies are key to visualise these RNAs in a given tissue or cell. This course will teach participants to apply three powerful RNA visualisation techniques, all in histological tissue samples: conventional in situ hybridisation (ISH), hybridisation chain reaction ISH (HCR-ISH), and the cutting edge single molecule fluorescent ISH (smFISH). In addition, essential tissues embedding protocols adapted to facilitate visual interrogation of RNA transcripts will also be covered. Benefit from our excellent trainer to participant ratio for personalised training...

23 October - 27 October 2023

Systems biology: from large datasets to biological insight

Jane Reynolds

This course covers the use of computational tools to extract biological insight from omics datasets The content will explore a range of approaches ranging from network inference and data integration to machine learning and logic modelling that can be used to extract biological insights from varied data types Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large scale biological data The motivation for running this course is a result of advances in computer science and high performance computing that have led to groundbreaking developments in systems biology model inference With the comparable increase of publicly available large scale biological data the challenge now lies in interpreting them in a biologically valuable manner Likewise machine learning approaches are making a significant impact in our analysis of large omics datasets and the extraction of useful biological knowledge Additional information Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course covers the use of computational tools to extract biological insight from omics datasets. The content will explore a range of approaches – ranging from network inference and data integration to machine learning and logic modelling – that can be used to extract biological insights from varied data types. Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large-scale biological data. The motivation for running this course is a result of advances in computer science and high-performance computing that have led to groundbreaking developments in systems biology model inference. With the comparable increase of publicly-available, large-scale biological data, the challenge now lies in interpreting them in a biologically valuable manner. Likewise, machine learning approaches are...

25 October - 27 October 2023

Proteomics in cell biology and disease mechanisms

Yu-Ju Chen, Ileana Cristea, Albert Heck, Matthias Mann

... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kitPre-conference workshop Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Conference overview Even after a few decades of great accomplishments, the field of proteomics remains to develop further, fueled by continued technological and computational advances in high-throughput methods and multi-omics big data integration. The ‘Proteomics in cell biology and disease mechanisms’ conference will provide attendees with a program that provides the current “state-of-affairs” in proteomics including a future perspective. It will be held at a pioneering hot spot for proteomics in Europe, in association with EMBL, in Heidelberg Germany. This year’s programme will focus on the latest technological advances with a focus on medical and clinical applications of...

1 November 2023

Exploring protein sequences and functional annotations with UniProt

UniProt provides the scientific community with a comprehensive high quality and freely accessible resource of protein sequence and functional information This webinar will guide you through ways in which students and researchers at all career stages may take a structured approach to access the data in the UniProt KnowledgeBase UniProtKB section of the UniProt protein function database We will discuss the types of protein data that can be accessed and using sequence analysis tools how this data can be analysed to answer biological questions We will demonstrate how to find the function of a protein how the protein components of a pathway may be identified features of proteins of interest can be compared similar sections of sequence can be sought in other species and how whole data sets containing all the proteins expressed in an organism can be obtained By accessing sequence structural and functional data through UniProt we want researchers to be part of a journey through biology and support further work and adventures along the way... UniProt provides the scientific community with a comprehensive, high-quality and freely accessible resource of protein sequence and functional information. This webinar will guide you through ways in which students and researchers at all career stages may take a structured approach to access the data in the UniProt KnowledgeBase (UniProtKB) section of the UniProt protein function database. We will discuss the types of protein data that can be accessed, and using sequence analysis tools, how this data can be analysed to answer biological questions. We will demonstrate how to find the function of a protein, how the protein components of a pathway may be identified, features of proteins of interest can be compared, similar sections of sequence can be sought in other species and how whole data sets containing all the proteins expressed in an organism can be obtained. By accessing sequence,...

6 November - 10 November 2023

Solution scattering from biological macromolecules

OverviewSpeakersVirtual programme 6 10 November 2023 On site programme 27 Nov 1 December 2023 Practical informationSponsorsMedia kit Overview Course overview This course consists of two parts a virtual module and an on site module The series of online lectures will take place from 6 10 November 2023 In addition to this a small number of selected students that have completed the... OverviewSpeakersVirtual programme (6-10 November 2023)On-site programme (27 Nov – 1 December 2023)Practical informationSponsorsMedia kit Overview Course overview This course consists of two parts: a virtual module and an on-site module. The series of online lectures will take place from 6 – 10 November 2023. In addition to this, a small number of selected students that have completed the virtual module will be offered to take part in the practical component of this course that will take place in Hamburg from 27 November – 1 December 2023. We encourage advanced PhD students, postdocs and junior researchers to apply. The virtual module lectures will cover the basics of SAXS/SANS, instrumentation, data collection, modelling techniques and complementary use with other methods. The students are also encouraged to sign-up for a self-paced practical tutorial that covers basic and advanced...

6 November - 9 November 2023

Preparation of genomics libraries for an emerging next-gen sequencing platform

Vladimir Benes, Bjorn Textor

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview This course will focus on the latest state of the art sequencing platform technology and novel library preparation protocols We will start with experimental design focusing on the hands on library preparation including best practices standards and potential pitfalls concluding with... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview This course will focus on the latest state-of-the-art sequencing platform technology and novel library preparation protocols. We will start with experimental design, focusing on the hands-on library preparation (including best practices, standards, and potential pitfalls), concluding with sequencing of libraries, bioinformatic evaluation & best practice. For this purpose we will use, for the first time ever in the settings of the practical course, the cutting-edge sequencing platform AVITI (https://www.elementbiosciences.com/products/aviti), which was developed by Element Biosciences and is currently entering the next-gen sequencing (NGS) field. An evaluation of the technology in conjunction with the newly developed library preparation reagents by New England Biolabs (NEB) will be...

7 November - 9 November 2023

Managing a bioinformatics core facility

Juanita Riveros

This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL EBI s service teams and from each other These facilities play an essential role in enabling research in the molecular life sciences The landscape is constantly evolving as new research tools emerge as experiments become increasingly data intensive and as their clients experimental researchers become more exposed to the power of data driven biology This course will allow participants to share experiences discuss challenges and solutions that they face and plan ways to cope with the ever changing demands raised by the molecular life science field It will include sessions to learn from bioinformatics service providers hear how others have tackled common problems and work together to design core services resource them and measure their impact A limited number or travel bursaries are available Please see the Additional information tab for conditions... This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL-EBI’s service teams, and from each other. These facilities play an essential role in enabling research in the molecular life sciences. The landscape is constantly evolving as new research tools emerge, as experiments become increasingly data intensive, and as their clients – experimental researchers – become more exposed to the power of data-driven biology. This course will allow participants to share experiences, discuss challenges and solutions that they face, and plan ways to cope with the ever changing demands raised by the molecular life science field. It will include sessions to learn from bioinformatics service providers, hear how others have tackled common problems, and work together to design core services, resource them, and measure their impact. A limited number...

7 November 2023

How to make your research open with Europe PMC

Europe PMC is an open global database of life science publications and preprints hosted by European Bioinformatics Institute EMBL EBI Europe PMC is endorsed and supported by a group of international science funders including Wellcome World Health Organisation European Research Council and many others as their repository of choice The Europe PMC funders expect research outputs arising from research they support to be made freely and readily available In this webinar we will explain how researchers can make their research open using Europe PMC and cover the benefits of including publications and preprints in Europe PMC for authors and readers We will provide guidance on open access policies of Europe PMC funders and demonstrate how to include research publications in Europe PMC and PubMed Central USA... Europe PMC is an open global database of life science publications and preprints hosted by European Bioinformatics Institute (EMBL-EBI). Europe PMC is endorsed and supported by a group of international science funders, including Wellcome, World Health Organisation, European Research Council, and many others, as their repository of choice.The Europe PMC funders expect research outputs arising from research they support to be made freely and readily available. In this webinar we will explain how researchers can make their research open using Europe PMC and cover the benefits of including publications and preprints in Europe PMC for authors and readers. We will provide guidance on open access policies of Europe PMC funders and demonstrate how to include research publications in Europe PMC and PubMed Central USA.

8 November - 11 November 2023

The mobile genome: genetic and physiological impacts of transposable elements

Déborah Bourc’his, Julius Brennecke, Jose L. Garcia-Perez, Susan Wessler

This conference is assembling world leading experts from diverse fields including genomics epigenetics structural biology developmental biology immunology cancer biology and neurobiology to discuss the broad impacts of TEs on organismal biology... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Abstract submission for posters are possible. Please contact Diah Yulianti at diah.yulianti@embl.de for more info. This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety recommendations if attending the on-site event. Conference overview This conference assembles world-leading experts from diverse fields including genomics, epigenetics, structural biology, developmental biology, immunology, cancer biology, and neurobiology to discuss the broad impacts of transposable elements (TEs) on organismal biology. The meeting provides a venue for cross-disciplinary discussions, with the goal of catalysing inter-disciplinary collaborations to address emerging questions in these scientific fields. Although often disparaged as “junk” DNA, it is now...

8 November 2023

Exploring protein families and domains using InterPro

InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites using predictive models provided by 13 different databases This webinar will take you through the different ways to search the InterPro website and its API to identify protein families and domains We will explore different use cases including how to use the InterPro sequence search functionality to identify the protein family membership the different domains and potentially the protein function of unknown proteins We will also explain how InterPro can be used to identify new protein domains using AlphaFold structure predictions... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites using predictive models provided by 13 different databases.  This webinar will take you through the different ways to search the InterPro website and its API to identify protein families and domains. We will explore different use cases, including how to use the InterPro sequence search functionality to identify the protein family membership, the different domains and potentially the protein function of unknown proteins. We will also explain how InterPro can be used to identify new protein domains using AlphaFold structure predictions

12 November - 14 November 2023

Protein Structure Determination in Industry 2023

EMBL EBI and GSK are co organising the 31st Protein Structure Determination in Industry Meeting hosted at the Hinxton Hall Conference Centre... Overview Overview 31st Protein Structure Determination in Industry (PSDI) meeting On behalf of the executive committee, we are delighted to invite you to the 31st Protein Structure Determination in Industry Meeting, which will be held at the Wellcome Genome Campus, Hinxton, Cambridge between November 12-14 2023. This year’s PSDI meeting is organised jointly by EMBL-EBI and GSK, supported by Hg3 Conferences. For the latest details on the Programme, Abstracts, Registration details, Accommodation, Exhibition, Venue please visit the dedicated conference microsite If you have any queries regarding the upcoming PSDI 2023 Conference, then please do not hesitate to contact Hg3 Conferences; By email: events@hg3.co.uk By phone: +44 (0) 1423 529333

13 November - 17 November 2023

Hands-on flow cytometry: learning by doing!

Daniel Diana Ordonez, Steffen Schmitt

Flow Cytometry is one of the most powerful single cell analysis methods used throughout the life sciences and medicine By utilising Flow Cytometry we can identify and quantify specific cell populations from heterogeneous samples analyse the cell cycle or proliferation state or simply detect the expression of fluorescent reporters In line with the suggestions from our course in 2019 we will significantly enhance the number of analysis sessions together with our partners from FlowJo We will cover the theory of Flow Cytometry and corroborate this information intensively with the practical issues of the most frequent assays as part of our practical course curriculum... OverviewSpeakers and trainersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview Flow cytometry is a highly effective method for analysing individual cells that has become widely used in the fields of life sciences and medicine. By utilising flow cytometry, researchers can accurately identify and measure specific cell populations within complex mixtures, as well as assess cell cycle progression, proliferation status, and expression of fluorescent markers. Our course aims to provide a comprehensive understanding of the underlying principles of flow cytometry, while also emphasising practical considerations related to the most frequently used assays. Through a combination of theoretical instruction and hands-on training, students will gain the knowledge and skills necessary to effectively design, execute, and interpret flow cytometry experiments. Audience...

15 November - 17 November 2023

Cancer genomics

Isidro Cortes Ciriano, Christina Curtis, Nuria Lopez-Bigas, Young Seok Ju

This meeting will provide an opportunity to learn about and keep up to date with the rapidly progressing area of cancer genomics We aim to bring together scientists from across several disciplines connected with cancer research for a unique opportunity to interact and stimulate further integration of these efforts... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Conference overview This meeting will provide an opportunity to learn about and keep up to date with the rapidly progressing area of cancer genomics. We aim to bring together scientists from across several disciplines connected with cancer research, for a unique opportunity to interact and stimulate further integration of these efforts. Highlights include talks from our keynotes Rebecca Fitzgerald (University of Cambridge, UK), Jan Korbel (EMBL Heidelberg, Germany), and 20 other great speakers. Session topics Mutation and clonal selection Cancer evolution Cancer genome medicine Emerging technologies in cancer genomics Genomic instability and mutational processes Cancer ecosystems and micro-environment What past participants...

15 November 2023

Complex Portal: from proteins to complexes

Complex Portal is a curated resource designed to offer insights into proteins and their higher level complexes These complexes play a crucial role in governing protein functionality and stability In this webinar we will introduce the portal and address how we define protein complexes how they are different from molecular interactions including the data curation priorities and coverage We will also demonstrate how to search complexes using a variety of accession numbers keywords and how to use the organism specific search Further we will also demonstrate examples of complex details pages that include visualisation tools and link outs to related databases... Complex Portal is a curated resource designed to offer insights into proteins and their higher-level complexes. These complexes play a crucial role in governing protein functionality and stability. In this webinar we will introduce the portal and address how we define protein complexes, how they are different from molecular interactions, including the data curation priorities and coverage. We will also demonstrate how to search complexes using a variety of accession numbers, keywords and how to use the organism specific search. Further, we will also demonstrate examples of complex details pages that include visualisation tools and link-outs to related databases.

20 November - 22 November 2023

25th EMBL PhD Symposium

2023 EMBL PhD Symposium Organising Committee

Join us for the 25th Anniversary of the annual EMBL PhD Symposium Since its conception in 1999 the EMBL PhD Symposium has evolved into a highly respected scientific meeting connecting young researchers and high profile scientists alike... If you are not redirected automatically, please go to PhD Symposium website.

20 November - 24 November 2023

Genome bioinformatics: from short- to long-read sequencing

Sophie Spencer

A guide to the technology analysis workflows tools and resources for next generation sequencing data analysis This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data The main focus will be on introducing sequence informatics re sequencing differences between short and long read sequencing and variant calling during the analysis of higher eukaryotes with an emphasis on human genetic research Throughout the week more advanced topics will introduce the creation of pipelines automation and the scaling up of analysis experiments Practical sessions will be run on datasets prepared by the trainers not on personal research data Participants will learn how to process these training datasets and to apply appropriate statistical methods in their analyses... A guide to the technology, analysis workflows, tools, and resources for next generation sequencing data analysis. This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data. The main focus will be on introducing sequence informatics, re-sequencing, differences between short- and long-read sequencing, and variant calling during the analysis of higher-eukaryotes, with an emphasis on human genetic research. Throughout the week, more advanced topics will introduce the creation of pipelines, automation, and the scaling-up of analysis experiments. Practical sessions will be run on datasets prepared by the trainers, not on personal research data. Participants will learn how to process these training datasets and to apply appropriate statistical methods in their analyses.

22 November 2023

Accessing single cell transcriptome data with the Human Cell Atlas Data Portal

The Human Cell Atlas is an ambitious project that aims to map the transcriptome of all the cell types in the human body This effort relies on single cell data generated from hundreds of labs across the globe which will be combined together into one comprehensive reference atlas The Data Portal helps to coordinate the data produced and standardise the format of data and metadata to reduce the burden of the integration efforts In this webinar we will provide an overview of data generation for HCA and how the data is curated for the Data Portal We will demonstrate how to navigate the Data Portal to find data that can be used for integration or as controls for your studies how to access the data and how to find the latest data from the integration efforts... The Human Cell Atlas is an ambitious project that aims to map the transcriptome of all the cell types in the human body. This effort relies on single cell data generated from hundreds of labs across the globe, which will be combined together into one comprehensive reference atlas. The Data Portal helps to coordinate the data produced and standardise the format of data and metadata, to reduce the burden of the integration efforts. In this webinar we will provide an overview of data generation for HCA and how the data is curated for the Data Portal. We will demonstrate how to navigate the Data Portal to find data that can be used for integration, or as controls for your studies, how to access the data, and how to find the latest data from the integration efforts.  

28 November - 1 December 2023

Subcortical sensory circuits: visual, auditory, somatosensory, and beyond

Hiroki Asari, Martha Bickford, Carl Petersen, Santiago Rompani

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Subcortical sensory circuits play a fundamental role in the perception of the outside world However they are often thought of as relay stations that passively transmit sensory information to... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Conference overview Subcortical sensory circuits play a fundamental role in the perception of the outside world. However, they are often thought of as relay stations that passively transmit sensory information to the cortex or simple effectors of behavioral reflexes. Recent studies, however, suggest that subcortical pathways also perform sophisticated computations, such as integrating peripheral information among many sensory pathways and the animal’s internal states. This meeting will gather leading researchers in the field to discuss different subcortical circuits involving various sensory modalities and revisit their increasingly complex and interconnected contributions to perception, behavior, and cognition....

29 November 2023

Studying metabolites and small molecules with MetaboLights and ChEBI

Metabolites are small molecules that play important roles in biological and cellular processes They act as signalling molecules serve as cofactors involved in energy production and storage and thus responsible for the maintenance growth and development of living organisms In this webinar we will first introduce metabolomics which focuses on the comprehensive analysis of metabolites within biological systems such as cells biofluids tissues or organisms from different ecosystems and health and environmental backgrounds In the second part of the webinar we will show how metabolite data is represented in MetaboLights an open access cross species and cross technique database for metabolomic experiments and derived information Studies in MetaboLights contain information across study design sample origin collection processing spectral data measurement data processing and metabolite identification The re use of data from MetaboLights can take various forms from identified metabolites towards interpretation with pathways reactions literature to a matrix for statistical modelling or even re processing of raw data In the final part of the webinar we will introduce MetaboLights partner database ChEBI that focuses on the nomenclature structure and biological properties of small molecules... Metabolites are small molecules that play important roles in biological and cellular processes. They act as signalling molecules, serve as cofactors, involved in energy production and storage, and thus responsible for the maintenance, growth, and development of living organisms.  In this webinar we will first introduce metabolomics, which focuses on the comprehensive analysis of metabolites within biological systems such as cells, biofluids, tissues or organisms from different ecosystems and health and environmental backgrounds. In the second part of the webinar, we will show how metabolite data is represented in MetaboLights, an open-access, cross-species, and cross-technique database for metabolomic experiments and derived information. Studies in MetaboLights contain information across study design, sample origin, collection, processing, spectral data measurement, data processing,...

30 November 2023

Interpreting the effects of genetic variants on protein structure and function

Meredith Willmott

Genetic variation between individuals results in a range of human phenotypes Variants that fall within coding regions of genes generally have direct and effects on the proteins encoded by the genes with which they overlap This four hour virtual workshop will provide participants with an opportunity to gain hands on experience of using EMBL EBI tools and resources to assess the effects of genetic variants on the structure and function of proteins in a common workflow During the course a single example will be used throughout using different EMBL EBI tools resources at each stage of the analysis pipeline The example will involve running a VCF file through the Ensembl Variant Effect Predictor VEP then following links to UniProt PDBe and AlphaFoldDB for further variant information and interpreation Virtual courseThis course will take place on Zoom Trainers will be available to assist answer questions and provide further explanations during the Zoom... Genetic variation between individuals results in a range of human phenotypes. Variants that fall within coding regions of genes generally have direct and effects on the proteins encoded by the genes with which they overlap. This four hour virtual workshop will provide participants with an opportunity to gain hands-on experience of using EMBL-EBI tools and resources to assess the effects of genetic variants on the structure and function of proteins in a common workflow. During the course, a single example will be used throughout, using different EMBL-EBI tools resources at each stage of the analysis pipeline. The example will involve running a VCF file through the Ensembl Variant Effect Predictor (VEP), then following links to UniProt, PDBe, and AlphaFoldDB for further variant information and interpreation. Virtual courseThis course will take place on Zoom. Trainers will be...

4 December - 8 December 2023

Fundamentals of widefield and confocal microscopy and imaging

Heiko Gaethje, Stefan Marawske, Jens Marquardt, Stefan Terjung

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview Light microscopy is the most widely used form of microscopy for life science research The correct handling of the microscope and optimising image quality e g contrast resolution as well as experimental design according to different applications are crucial to obtain the best results... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview Light microscopy is the most widely used form of microscopy for life science research. The correct handling of the microscope and optimising image quality (e.g. contrast, resolution) as well as experimental design according to different applications are crucial to obtain the best results. This course will provide the participants with an overview of the basics of microscopy (light and optics, contrast techniques and imaging). The confocal part will include multicolour, 3D and time-lapse imaging as well as spectral imaging, photobleaching (FRAP, FLIP, FLAP) and photoactivation techniques. Basic image analysis tools including measurement functions, colocalisation and spectral unmixing as well as 3D/4D image processing will be covered, both in theory and practice. The course will combine...

6 December - 9 December 2023

Computational structural biology

Jan Kosinski, Rommie Amaro, Christine Orengo, Sameer Velankar

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please note that we now only accept abstract submissions for poster presentation only If you wish to submit a poster please contact us Conference overview The field of computational structural biology is... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please note that we now only accept abstract submissions for poster presentation only. If you wish to submit a poster, please contact us. Conference overview The field of computational structural biology is undergoing a revolution. AlphaFold, a program based on Artificial Intelligence (AI), has transformed the structural modeling of proteins and protein complexes by reaching accuracy similar to experimental structures. Over 200 million structural models have already been released in AlphaFold Database. Following AlphaFold, other protein modeling programs proliferated from researchers worldwide. AI has started advancing RNA modeling too. The wealth of protein models has sparked an explosion of new tools for structural...

22 January - 26 January 2024

Exploratory analysis of biological data: data carpentry

Renato Alves, Lisanna Paladin, Fotis E. Psomopoulos, Christian Schudoma

This hands on workshop teaches researchers the fundamental data skills they need to conduct their work and provides high quality domain specific training covering the full lifecycle of data driven research... OverviewSpeakersProgrammePractical information Overview Course overview The missing step between data collection and research progress is a lack of training for researchers in crucial skills for effectively managing and analysing data, often in large amounts. This hands-on workshop teaches researchers the fundamental data skills they need to conduct their work and provides high-quality, domain-specific training covering the full lifecycle of data-driven research. The domain-specific approach allows participants to tailor the data, content, and tools to reflect the specific data and analysis needs of different areas. Audience The course is aimed at graduate students and other researchers in the life sciences who would like to learn good practices in project and data organisation and computational data analysis with R. The course is ideally suited to students without prior experience in...

29 January - 31 January 2024

Cryo-EM in academia and industry

Edward Avenell, Chun-wa Chung, Simone Mattei, Christoph Mueller, Chiara Rapisarda

OverviewSpeakersPreliminary programmePractical informationSponsors PartnersMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The second edition of this workshop aims to bring the academic and industrial cryo EM communities together to evaluate how the use of cryo EM has developed 10 years on from the cryo... OverviewSpeakersPreliminary programmePractical informationSponsors & PartnersMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Conference overview The second edition of this workshop aims to bring the academic and industrial cryo-EM communities together to evaluate how the use of cryo-EM has developed 10 years on from the “cryo-EM resolution revolution” and build upon the successful first edition held at EMBL in 2019. Showcasing high-quality research in academia and industry relevant and exemplary for both cryo-EM communities, the meeting will provide updates on recent and ongoing methodological developments. A particular focus will be on the integration of cryo-ET and cryo-EM with complementary imaging techniques, e.g. imaging across scales as well as other ‘omics’ technologies such as proteomics, genomics, and metabolomics....

4 February - 9 February 2024

Analysis and integration of transcriptome and proteome data

Vladimir Benes, Raffaele Calogero, Jeroen Krijgsveld, Lennard Martens

OverviewSpeakersPractical informationSponsorsMedia kit Overview Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells tissues and organisms operate in their biological context Among the key technologies driving this forward are next generation sequencing and proteomics as they provide powerful means to determine... OverviewSpeakersPractical informationSponsorsMedia kit Overview Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells, tissues and organisms operate in their biological context. Among the key technologies driving this forward are next-generation sequencing and proteomics, as they provide powerful means to determine global expression levels of genes and proteins. Both fields have matured to a degree that they have now become accessible to researchers in many areas of biology. During this course, participants will gain theoretical insight in the structure of sequencing and proteomic data, and they will receive training in data analysis for the annotation, quantification, and statistical analysis of gene and protein expression using various computational tools. In addition, training will be provided in the use of...

12 February - 16 February 2024

Introduction to RNA-seq and functional interpretation

Juanita Riveros

Gain an introduction to the technology data analysis tools and resources used in RNA sequencing and transcriptomics The content will provide a broad overview of the subject area and introduce participants to basic analysis of transcriptomics data using the command line It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data Topics will be delivered using a mixture of lectures practical exercises and open discussions Computational work during the course will use small example data sets and there will be no opportunity to analyse personal data Virtual course Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 00 16 00 hrs GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times... Gain an introduction to the technology, data analysis, tools, and resources used in RNA sequencing and transcriptomics. The content will provide a broad overview of the subject area, and introduce participants to basic analysis of transcriptomics data using the command line. It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data. Topics will be delivered using a mixture of lectures, practical exercises, and open discussions. Computational work during the course will use small, example data-sets; and there will be no opportunity to analyse personal data.   Virtual course Participants will learn via a mix of pre-recorded lectures, live presentations, and trainer Q&A sessions. Practical experience will be developed through group activities and trainer-led computational exercises. Live sessions...

19 February - 23 February 2024

Exploring gene and environmental exposure interactions to understand human health and disease

Sophie Spencer

This introductory course explores the complex interplay between genes and the environment in shaping human phenotypes Participants will gain knowledge of cohort datasets environmental readouts and computational resources to investigate gene environment interactions Ethical and legal frameworks related to data privacy consent and genetic discrimination will be discussed The course also covers computational modelling techniques for integrating genotype and environmental effects By the end attendees will be equipped to analyse cohort datasets make use of computational resources and interpret the results Please note that you will not analyse your own data as part of the course There will however be ample opportunity to discuss your research and ideas with other course participants and trainers... This introductory course explores the complex interplay between genes and the environment in shaping human phenotypes. Participants will gain knowledge of cohort datasets, environmental readouts, and computational resources to investigate gene-environment interactions. Ethical and legal frameworks related to data privacy, consent, and genetic discrimination will be discussed. The course also covers computational modelling techniques for integrating genotype and environmental effects. By the end, attendees will be equipped to analyse cohort datasets, make use of computational resources, and interpret the results. Please note that you will not analyse your own data as part of the course. There will, however, be ample opportunity to discuss your research and ideas with other course participants and trainers

20 February - 23 February 2024

The new cardiobiology

Pilar Alcaide, Johannes Backs, Tina Haase, Enzo Porrello

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The cardiovascular system is a multicellular and disseminated organ consisting of the heart a network of vessels and circulating blood thereby forming an intricately interdependent system whose... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Conference overview The cardiovascular system is a multicellular and disseminated organ consisting of the heart, a network of vessels and circulating blood, thereby forming an intricately interdependent system, whose dysfunction is the leading cause of human mortality. Despite translational progress with impactful new interventional and pharmacological therapies, cardiovascular dysfunction continues to plague mankind. The current therapeutic approaches are either organ-centric or tackle the consequences of end-stage cardiovascular disease (CVD). New basic research approaches are focused on a deeper understanding of the causes and early development of CVD to identify mechanisms close to the root of the...

27 February - 1 March 2024

Integrative analysis of multi-omics data

Wolfgang Huber, Oliver Stegle, Britta Velten

OverviewSpeakersPreliminary ProgrammePractical informationSponsorsMedia kit Overview Course overview Biological and biomedical research is increasingly driven by assays that measure multiple omics data types multi omics at single cell resolution and or with spatial resolution transcriptome proteome genomic variants epigenetic marks metabolome functional assays imaging Jo... OverviewSpeakersPreliminary ProgrammePractical informationSponsorsMedia kit Overview Course overview Biological and biomedical research is increasingly driven by assays that measure multiple ‘omics data types (“multi-omics”), at single cell resolution, and/or with spatial resolution: transcriptome, proteome, genomic variants, epigenetic marks, metabolome, functional assays, imaging. Joint mathematical-computational modeling, mechanistic and integrated statistical analysis of such data is an urgent need – one of the major analytical challenges scientists face today. How to discover the important underlying patterns, categories or trends, and to arrive at statistically robust conclusions using explainable models of reasoning? The course’s core objective is to convey conceptual and mathematical foundations that underpin existing and emerging integrative multimodal data strategies and...

4 March - 8 March 2024

Introduction to multi-omics data integration and visualisation

Meredith Willmott

With the increase in the volume of data across the whole spectrum of biology more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences This may also include public domain data which can provide added value to data derived through researcher s own work and inform experimental design This introductory course will highlight the challenges that researchers face in integrating multi omics data sets using biological examples The course will focus on the use of public data resources and open access tools for enabling integrated working with an emphasis on data visualisation This course will not include systems biology modelling or machine learning A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI data resource and research teams This allows people to explore the bioinformatics tools and resources introduced in the course and to apply these to a set problem providing hands on experience of relevance to their own research The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of integrating data You may refer to the previous group projects that were organised for this course in March 2023... With the increase in the volume of data across the whole spectrum of biology, more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences. This may also include public domain data, which can provide added value to data derived through researcher’s own work and inform experimental design. This introductory course will highlight the challenges that researchers face in integrating multi-omics data sets using biological examples. The course will focus on the use of public data resources and open access tools for enabling integrated working, with an emphasis on data visualisation. This course will not include systems biology modelling or machine learning.A major element of this course is a group project, where participants will be placed in small groups to work together on a challenge set by trainers from EMBL-EBI data...

4 March - 8 March 2024

Gene expression at spatial resolution

Vladimir Benes, Dirk Jürgensen, Elisabeth Zielonka

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview More information about this course will be available soon Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview More information about this course will be available soon. Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other events, or contact sponsorship@embl.de for further information. If you are interested in becoming a media partner of this event, please visit our media partnerships webpage. Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship...

11 March - 15 March 2024

Mathematics of life: modelling molecular mechanisms

Juanita Riveros

This course will provide participants with an introduction and hands on training on modelling approaches tools and resources used in systems biology as well as touch on network analysis Computer models are increasingly used to understand the essential processes of biology Researchers in academic institutions as well as the pharmaceutical industry use mathematical models to generate hypotheses on how complex biomolecular systems work Modelling of biochemical pathways deregulated in disease conditions can offer mechanistic insights into the pathology help to elucidate mechanisms behind drug action and predict the dose required for treatment thus facilitating fundamental research and drug discovery This course will provide a helpful brief introduction to key modelling concepts and hands on training to use popular tools and resources used in this scientific field Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 00 17 30 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times... This course will provide participants with an introduction and hands-on training on modelling approaches, tools, and resources used in systems biology as well as touch on network analysis.Computer models are increasingly used to understand the essential processes of biology. Researchers in academic institutions as well as the pharmaceutical industry use mathematical models to generate hypotheses on how complex biomolecular systems work. Modelling of biochemical pathways deregulated in disease conditions can offer mechanistic insights into the pathology, help to elucidate mechanisms behind drug action, and predict the dose required for treatment thus facilitating fundamental research and drug discovery. This course will provide a helpful brief introduction to key modelling concepts and hands on training to use popular tools and resources used in this scientific field.Virtual...

12 March - 15 March 2024

AI and biology

Mohammed AlQuraishi, Wolfgang Huber, Anna Kreshuk, Emma Lundberg, Oliver Stegle

The aim of this symposium is to catalyse synergistic interactions between AI researchers in different subfields of biology by exploring shared theoretical approaches cross domain experiments and data integration as well as shared topics in dissemination of tools and collaboration with colleagues in experimental labs... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Symposium overview Artificial intelligence (AI) is transforming virtually all areas of science, and the life sciences are no exception. AI-based methods are pushing the limits of what is possible in experimental design, data analysis, simulation, and modelling. The aim of this symposium is to catalyse synergistic interactions between AI researchers in different subfields of biology by exploring shared theoretical approaches, cross-domain experiments, and data integration, as well as shared topics in dissemination of tools and collaboration with experimental labs. Furthermore, we will look into the future and discuss how the concerted actions of AI and life science communities can enable both fields to exploit...

18 March - 22 March 2024

Livestock genomics

Sophie Spencer

This hands on virtual course will introduce participants to methods and approaches for analysing genomic data from common livestock species During the course participants will learn about the use of sequencing methods in the field of livestock genomics resequencing genomes locating variant data annotating genomes and carrying out GWAS approaches The course will also cover the use of public EMBL EBI resources such as Ensembl EVA and ENA to progress in your research as well as to submit and share your discoveries with the community and will present relevant use cases in the field Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 00 18 30 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times... This hands-on virtual course will introduce participants to methods and approaches for analysing genomic data from common livestock species. During the course participants will learn about the use of sequencing methods in the field of livestock genomics, resequencing genomes, locating variant data, annotating genomes, and carrying out GWAS approaches. The course will also cover the use of public EMBL-EBI resources such as Ensembl, EVA, and ENA to progress in your research, as well as to submit and share your discoveries with the community, and will present relevant use cases in the field.Virtual courseParticipants will learn via a mix of pre-recorded lectures, live presentations, and trainer-led computational exercises. Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack.Pre-recorded material may be provided before the...

19 March - 22 March 2024

Biological oscillators: rhythms and synchronisation across scales

Alexander Aulehla, Alan Hastings, Hanspeter Herzel, Carrie Partch

OverviewSpeakersSponsorsAboutMedia Kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Symposium overview Are you interested to discuss and learn about oscillatory phenomena and biological dynamics across a... OverviewSpeakersSponsorsAboutMedia Kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview Are you interested to discuss and learn about oscillatory phenomena and biological dynamics across a wide range of fields? At this symposium, multiple disciplines will come together in order to discuss common themes linked to oscillations and rhythms, across different temporal and spatial scales. This meeting provides a unique platform to bring together a interdisciplinary community working at the interface between quantitative biology, complex oscillatory systems, and physics. Oscillations and rhythms are abundant – hormonal cycles with periods of days and months, circadian clocks, embryonic oscillators,...

19 March - 22 March 2024

Protein quality control for downstream processes

Karine Lapouge, Kim Remans, Bertrand Raynal

OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Purified proteins are used in various types of scientific experiments and fields For example in structural biology insights into the functional mechanisms can be obtained by elucidating the 3D molecular structure of proteins and protein complexes using technologies such as X ray crystallography... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Purified proteins are used in various types of scientific experiments and fields. For example, in structural biology insights into the functional mechanisms can be obtained by elucidating the 3D molecular structure of proteins and protein complexes using technologies such as X-ray crystallography, cryo-EM and NMR. In biochemistry and biophysics, interactions with other proteins, nucleic acids and small molecules can be studied by determining affinities and specificities. Proteins can function as antigens to generate specific antibodies or as reagents in cell biology experiments. Furthermore, recombinant proteins can be used as tool molecules in genomics, chemical biology and microscopy assays. In order for these experiments to produce reliable and biologically relevant results, they must be performed...

3 April - 5 April 2024

Exploring human genetic variation

Juanita Riveros

This course is currently under development please check back again soon for further details... This course is currently under development, please check back again soon for further details.

8 April - 12 April 2024

Data-driven approaches to understanding dementia

Juanita Riveros

This course provides individuals working in dementia research with the skills to access and analyse dementia data Participants will learn to apply bioinformatics methodologies combine different data types and utilise relevant dementia data resources enhancing their research capabilities in the field... This course provides individuals working in dementia research with the skills to access and analyse dementia data. Participants will learn to apply bioinformatics methodologies, combine different data types, and utilise relevant dementia data resources, enhancing their research capabilities in the field.

8 April - 12 April 2024

scATAC-seq: attacking open chromatin in single cells

Vladimir Benes, Ulrike Litzenburger, Judith Zaugg

ATAC Seq stands for Assay of Transposase Accessible Chromatin and is a widespread method to profile open chromatin on a genome scale The goal of this introductory course is to teach the entire workflow of a single cell and bulk ATAC Seq experiment including library preparation sequencing data processing and downstream analysis by addressing a real biological question that will be answered at the end of the course... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview ATAC-Seq stands for Assay of Transposase Accessible Chromatin and is a widespread method to profile open chromatin on a genome-scale. The goal of this introductory course is to teach the entire workflow of a single-cell and bulk ATAC-Seq experiment including library preparation, sequencing, data processing, and downstream analysis by addressing a real biological question that will be answered at the end of the course. We will start with the experimental single-cell and bulk ATAC-Seq protocol, highlighting the critical steps, potential pitfalls, and the most up-to-date tweaks to improve the quality of the results. After sequencing the samples we will go through the basic quality control and preprocessing steps using...

9 April - 12 April 2024

Diversity of plants: from genomes to metabolism

Barbara Ann Halkier, Sarah E. O’Connor, Detlef Weigel

OverviewSpeakersPreliminary programmePractical informationSponsorsAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety recommendations if attending the on site event Symposium overview This inaugural EMBO EMBL Symposium will showcase the future of plant biology Going beyond the limited number of wild... OverviewSpeakersPreliminary programmePractical informationSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety recommendations if attending the on-site event. Symposium overview This inaugural EMBO | EMBL Symposium will showcase the future of plant biology. Going beyond the limited number of wild and crop plants that have historically been focused on, modern comparative approaches are revealing the mechanistic bases and evolutionary forces driving the enormous phenotypic variation among the 400,000 plant species on Earth. This conference is for biologists with an interest in plant diversity at the genomic, (epi)genetic, phenotypic and metabolic level. The major topical threads will be the biology of genomes, evolution of metabolic pathways, and evolution of environment-dependent and...

15 April - 18 April 2024

The mechanics of life: from development to disease

Prisca Liberali, Nicoletta Petridou, Amy Shyer, Andela Saric, Xavier Trepat

OverviewSpeakersSponsorsAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Symposium overview The building blocks of life macromolecules cells tissues and organs act on each other via physical forces... OverviewSpeakersSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview The building blocks of life – macromolecules, cells, tissues, and organs – act on each other via physical forces. This interplay of physical forces between the units of life gives rise to complex behaviour – enables motility, transport, growth, division, response to environmental cues, and allows the exertion of forces on the environment, bridging biological scales. The alteration of forces and mechanical properties is associated with inflammation, cancer and ageing. This comprehensive symposium will study the interplay of the physical forces – the mechanics – between the fundamental building blocks of life,...

15 April - 19 April 2024

Ultrastructure expansion microscopy

Niccolo Banterle, Gautam Dey, Paul Guichard, Virginie Hamel, Marine Laporte

Expansion microscopy ExM physically magnifies specimens allowing to obtain super resolution images using a conventional diffraction limited microscope such as confocal microscopy This powerful technique is easy to implement but it requires some hands on training... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Expansion microscopy (ExM) physically magnifies specimens, allowing to obtain super-resolution images using a conventional diffraction-limited microscope such as confocal microscopy. This powerful technique is easy to implement but it requires some hands-on training. The gain in resolution can be further enhanced with the use of super-resolution microscopes such as STED. This course centered on the Ultrastructure Expansion Microscopy (U-ExM) based techniques applied to mammalian cells aims at disseminating and discussing expansion microscopy protocols and is intended for cell biologists, parasitologists, etc, with applications ranging from tissue to cells. Audience This...

22 April - 26 April 2024

Microscopy data analysis: machine learning and the BioImage Archive

Meredith Willmott

This virtual course will show how public bioimaging data resources centred around the BioImage Archive enable and enhance machine learning based image analysis The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi modal imaging data at the cell and tissue scale Participants will cover contemporary biological image analysis with an emphasis on machine learning methods as well as how to access and use images from databases Further instruction will be offered using applications such as ZeroCostDL4Mic ilastik the BioImage Model Zoo and CellProfiler Virtual course This course will be a virtual event delivered via a mixture of live streamed sessions pre recorded lectures and tutorials with live support We will be using Zoom to run the live sessions all fully password protected with automated English closed captioning and transcription with support and both scientific and social networking opportunities provided by Slack and other methods taking different time zones into account In order to make the most out of the course you should make sure to have a stable internet connection throughout the week and are available between 08 00 18 00 BST each day In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Selected participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course... This virtual course will show how public bioimaging data resources, centred around the BioImage Archive, enable and enhance machine learning based image analysis. The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi-modal imaging data at the cell and tissue scale. Participants will cover contemporary biological image analysis with an emphasis on machine learning methods, as well as how to access and use images from databases. Further instruction will be offered using applications such as ZeroCostDL4Mic, ilastik, the BioImage Model Zoo, and CellProfiler. Virtual course This course will be a virtual event delivered via a mixture of live-streamed sessions, pre-recorded lectures, and tutorials with live support. We will be using Zoom to run the live sessions (all fully password protected with automated English closed captioning...

22 April - 26 April 2024

Fundamentals of widefield and confocal microscopy and imaging

Heiko Gaethje, Jens Marquard

This course will provide the participants with an overview of the basics of microscopy light and optics contrast techniques and imaging... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Light microscopy is the most widely used form of microscopy for life science research. The correct handling of the microscope and optimising image quality (e.g. contrast, resolution) as well as experimental design according to different applications are crucial to obtain the best results. This course will provide the participants with an overview of the basics of microscopy (light and optics, contrast techniques and imaging). The confocal part will include multicolour, 3D, and time-lapse imaging as well as spectral imaging, photobleaching (FRAP, FLIP, FLAP) and photoactivation techniques. Basic image analysis tools including measurement functions, colocalisation, and spectral unmixing as well as 3D/4D image processing...

23 April - 26 April 2024

Organismal physiology

Gerard Karsenty, Irene Miguel-Aliaga, Asya Rolls, Miguel Soares

This symposium aims to provide a high visibility platform to scientists from multiple disciplines who use molecular genetic tools to probe inter organ communication signals that maintain homeostasis It will also directly address a fundamental and long term goal of the study of physiology how can recent developments in whole organism physiology pave the way to novel adapted and efficient therapies for multiple degenerative diseases... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Symposium overview “Like a machine, any organism, even the simplest, is a functional unit, coherent and integrated. We are far from having elucidated, in complex organisms, the entire structure of these functional units”. A major outcome of research using model organisms has been to address this central question of biology that was stated so clearly and candidly by J. Monod in 1969. Genetic studies in model organism have first revealed that we are far from knowing all the functions fulfilled by various organs in vertebrates or invertebrates. In doing so, this body of work has nonetheless led to unprecedented progress in our understanding of how homeostasis of an entire organism is maintained. As a result, modern...

6 May - 8 May 2024

Building networks 2024: engineering in vascular biology

Maria Bernabeu, Claudio Franco, Stephan Huveneers, Milica Radisic

In this meeting we intend to bring together vascular biologists and bioengineers from across the world to build research synergies to tackle long standing questions in the field of vascular biology... OverviewSpeakersPreliminary programmeSponsorsMedia kit Overview This conference will take place at EMBL Barcelona. Conference overview Blood vessels are essential for the formation and maintenance of larger tissues and organs. The vascular system regulates exchange of oxygen, nutrients and immune cells – the dysfunction of which can cause severe pathologies. Mouse models, genetics and histology of human samples, coupled with recent advances in imaging, single-cell approaches and computational modelling, have provided significant knowledge to the field of vascular biology. Yet, in vivo models are highly complex and often need to be combined with simpler in vitro studies to get mechanistic and molecular insights. Growth of in vitro blood vessels presents numerous research challenges due to their complex 3D geometry, and a strong coupling between biology and mechanics.Recent advances...

8 May - 10 May 2024

Bioinformatics resources for protein biology

Sophie Spencer

This course is currently under development please check back again soon for further details... This course is currently under development, please check back again soon for further details.

12 May - 17 May 2024

Advanced fluorescence imaging techniques

Manuel Gunkel, Aliaksandr Halavatyi, Debora Keller-Olivier Joana Delgado Martins, Irina Rakotoson

This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms Invited guest researchers together with experts from the EMBL and microscopy professionals will foster an intense information flow with a balance of lectures and practical workshops The focus of the course will be on the use of fluorescence microscopy to obtain information about protein localisation dynamics and functions at different spatial scales... OverviewSponsorsMedia Kit Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms. Invited guest researchers together with microscopy experts from EMBL will foster an intense information flow with a balance of lectures and practical workshops. The focus of the course will be on the use of fluorescence microscopy to obtain information about localisation and functions of proteins and other bio-molecules at different spatial scales. Audience This course is directed towards researchers in the life sciences with access to light microscopy equipment, who have an immediate need to apply the...

13 May - 17 May 2024

Introduction to metabolomics analysis

Meredith Willmott

This course will provide an introduction to metabolomics through lectures and hands on sessions using publicly available data software and tools Participants will become familiar with the current state of experimental design data acquisition LC MS MS imaging processing and modelling In addition they will learn about community standards and sharing in metabolomics particularly through using the EMBL EBI s MetaboLights repository and Galaxy infrastructure Participants will learn through hands on tutorials to use tools available for data analysis and data submission Additionally case studies will be used to discuss and show how to employ the week s learning This course is currently under development please check back again soon for further details... This course will provide an introduction to metabolomics through lectures and hands-on sessions, using publicly available data, software, and tools. Participants will become familiar with the current state of experimental design, data acquisition (LC-MS, MS imaging), processing, and modelling. In addition, they will learn about community standards and sharing in metabolomics, particularly through using the EMBL-EBI’s MetaboLights repository and Galaxy infrastructure. Participants will learn through hands-on tutorials to use tools available for data analysis and data submission. Additionally, case studies will be used to discuss and show how to employ the week’s learning. This course is currently under development, please check back again soon for further details.

14 May - 17 May 2024

Cellular mechanisms driven by phase separation

Simon Alberti, Sara Cuylen-Häring, Dorothee Dormann, Alex Holehouse

This conference will bring together scientists from soft matter polymer physics molecular biology structural biology and cell and developmental biology to study condensates in biology and disease... OverviewSpeakersSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview The realisation that intracellular phase transitions underlie the formation of membrane-less compartmentalisation in cells has transformed our understanding of cellular organisation. While the existence of membrane-less organelles, such as nucleoli, stress granules, and Cajal bodies had been known for a long time, it had remained largely unclear until recently how they were formed, maintained, and regulated. Biomolecular condensates are often highly dynamic, and continuously exchange their components with the surrounding environment. These properties enable tight, cooperative regulation of compartmentalisation,...

21 May - 23 May 2024

BioMalPar XX: biology and pathology of the malaria parasite

S. Absalon, J. Bryant, F. Okumu, T. Kooij

OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview Malaria remains one of the most significant global public health challenges with more than 200 million clinical... OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview Malaria remains one of the most significant global public health challenges, with more than 200 million clinical cases worldwide each year. The lack of a vaccine that provides effective long-term protection and the continual emergence of drug-resistant malaria parasites emphasises the need for new control and prevention strategies. This need for innovation has become even more apparent with the disruption of global malaria control programs due to the COVID-19 pandemic and potential reversal of gains made over the last few decades, highlighted through a marked increase in malaria deaths in recent years. The generation of...

26 May - 31 May 2024

Whole transcriptome data analysis

Marco Beccuti, Vladimir Benes, Raffaele Calogero, Francesca Cordero

This course will teach the biological researchers how to analyse biological data sets using open source software Most of the analysis will be performed with docker4seq and rCASC packages which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview This course will teach the biological researchers how to analyse biological data sets using open-source software. Most of the analysis will be performed with docker4seq and rCASC packages, which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis. Docker4seq and rCASC packages use docker containers that embed demanding computing tasks (e.g. short reads mapping) into isolated containers. This approach provides multiple advantages: the user does not need to install all the software on its local server, the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used...

1 June - 8 June 2024

Structural characterisation of macromolecular complexes

Ana Casanal, Wojciech Galej, Eva Kowalinski, Carlo Petosa, Montserrat Soler López

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Recent developments in cryo EM ET super resolution microscopy and protein structure prediction coupled with increasingly sophisticated methods of sample preparation have revolutionised structural biology... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Recent developments in cryo-EM/ET, super-resolution microscopy, and protein structure prediction — coupled with increasingly sophisticated methods of sample preparation — have revolutionised structural biology. Educating the next generation of researchers on how to strategically combine these disparate tools is critical for addressing the most challenging structural biology problems of the future. Course participants will receive a comprehensive overview of state-of-the-art structural methods, with a focus on sample preparation, characterisation, and data integration strategies. Key aspects covered by lectures and practicals include multi-subunit protein expression in bacteria, insect, and mammalian cells; isolation of...

3 June - 7 June 2024

Systems biology: from large datasets to biological insight

Juanita Riveros

This course covers the use of computational tools to extract biological insight from omics datasets The content will explore a range of approaches ranging from network inference and data integration to machine learning and logic modelling that can be used to extract biological insights from varied data types Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large scale biological data The motivation for running this course is a result of advances in computer science and high performance computing that have led to groundbreaking developments in systems biology model inference With the comparable increase of publicly available large scale biological data the challenge now lies in interpreting them in a biologically valuable manner Likewise machine learning approaches are making a significant impact in our analysis of large omics datasets and the extraction of useful biological knowledge This course is currently under development please check back again soon for further details... This course covers the use of computational tools to extract biological insight from omics datasets. The content will explore a range of approaches – ranging from network inference and data integration to machine learning and logic modelling – that can be used to extract biological insights from varied data types. Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large-scale biological data. The motivation for running this course is a result of advances in computer science and high-performance computing that have led to groundbreaking developments in systems biology model inference. With the comparable increase of publicly-available, large-scale biological data, the challenge now lies in interpreting them in a biologically valuable manner. Likewise, machine learning approaches are...

5 June - 8 June 2024

Microtubules: from atoms to complex systems

Carsten Janke, Thomas Müller-Reichert, Shinsuke Niwa, Kassandra Ori-Mckenney

In recent years interdisciplinary approaches embracing cell biology genetics molecular biology biochemistry biophysics structural biology and mathematical modelling have made a tremendous impact on the microtubule field... OverviewSpeakersSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview This symposium, initiated in 2010, has taken place every second year since and brings together early-career and established researchers from all over the world who are interested in microtubule biology and its impact on human health and disease. The microtubule cytoskeleton is essential for a wide variety of cellular functions, such as chromosome segregation, directed vesicle and organelle transport, cell motility and cell polarity. Impaired microtubule function can lead to human diseases including cancer and neurodegenerative disorders, where microtubules serve as important therapeutic targets. In recent years,...

9 June - 15 June 2024

C. elegans: from genome editing to imaging

Simone Köhler, Georgia Rapti

OverviewSponsorsMedia kit Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview C elegans is a popular experimental model that combines transparency reproducible anatomy traceable cell lineage sequenced genome and facile genetics allowing to dissect animal development physiology and... OverviewSponsorsMedia kit Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview C. elegans is a popular experimental model that combines transparency, reproducible anatomy, traceable cell lineage, sequenced genome and facile genetics, allowing to dissect animal development, physiology, and behaviour across scales of genes, cells and tissues. This 7-day course will present experimental practices in C. elegans research, while introducing historic and up-to-date findings in various research topics.Each day includes lectures, practicals, students flash-talks and interactive discussions with faculty. A series of methodologies commonly employed in C. elegans research will be presented in parallel practicals with rotating student groups by relevant experts. These experimental techniques span...

11 June - 13 June 2024

Bioinformatics for principal investigators

Jane Reynolds

This course is currently under development please check back again soon for further details... This course is currently under development, please check back again soon for further details.

17 June - 21 June 2024

Summer school in bioinformatics

Sophie Spencer

This course provides an introduction to the use of bioinformatics in biological research giving participants guidance for using bioinformatics in their work whilst also providing hands on training in tools and resources appropriate to their research Participants will initially be introduced to bioinformatics theory and practice including best practices for undertaking bioinformatics analysis data management and reproducibility To enable specific exploration of resources in their particular field of interest participants will then be divided into focused groups to work on a project This course is currently under development please check back again soon for further details... This course provides an introduction to the use of bioinformatics in biological research, giving participants guidance for using bioinformatics in their work whilst also providing hands-on training in tools and resources appropriate to their research. Participants will initially be introduced to bioinformatics theory and practice, including best practices for undertaking bioinformatics analysis, data management, and reproducibility. To enable specific exploration of resources in their particular field of interest, participants will then be divided into focused groups to work on a project. This course is currently under development, please check back again soon for further details.

18 June - 21 June 2024

Innate immunity in host-pathogen interactions

Gordon Brown, Michaela Gack, Felix Randow, Dominique Soldati-Favre, Cyril Zipfel

OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview This follow up meeting to the successful EMBO EMBL Symposia Innate immunity in Host Pathogen Interactions in 2016 2018 and 2022 will provide a discussion and networking platform for all... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Symposium overview This follow-up meeting to the successful EMBO | EMBL Symposia ‘Innate immunity in Host Pathogen Interactions’ in 2016, 2018 and 2022 will provide a discussion and networking platform for all scientists interested in the biology of pathogen infection. The symposium will promote the exchange of conceptual ideas in this rapidly evolving field, and also foster cross-disciplinary collaborations among the scientists. Innate immunity is studied by both microbiologists and immunologists; however, their perspectives differ widely. Microbiologists are necessarily specialists for their pathogen(s) of choice, while immunologists tend to focus on the host response. The goal of the conference is...

24 June - 28 June 2024

Cancer genomics and transcriptomics

Meredith Willmott

This course will focus on the analysis of data from genomic studies of cancer It will also highlight the application of transcriptomic analysis and single cell technologies in cancer Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers This course is currently under development please check back again soon for further details... This course will focus on the analysis of data from genomic studies of cancer. It will also highlight the application of transcriptomic analysis and single-cell technologies in cancer. Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data, whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers. This course is currently under development, please check back again soon for further details.

1 July - 5 July 2024

Bioinformatics for immunologists

Juanita Riveros

This course will provide participants with an introduction to a range of bioinformatics resources and approaches applicable to immunological research The resources introduced during the course will cover a variety of data types from genomic and proteomic data to computational models biological pathways and reaction information Participants will gain experience in analysis pipelines for NGS experiments relevant to immunology and will be led through an exploration of this data to identify information of interest Additionally participants will be introduced to how data from several sources can be integrated to provide a wider view of their research thereby enabling them to be more confident users of their own data and that from public sources This course is currently under development please check back again soon for further details... This course will provide participants with an introduction to a range of bioinformatics resources and approaches applicable to immunological research. The resources introduced during the course will cover a variety of data types, from genomic and proteomic data to computational models, biological pathways, and reaction information. Participants will gain experience in analysis pipelines for NGS experiments relevant to immunology and will be led through an exploration of this data to identify information of interest. Additionally, participants will be introduced to how data from several sources can be integrated to provide a wider view of their research, thereby enabling them to be more confident users of their own data and that from public sources. This course is currently under development, please check back again soon for further details.

8 July - 12 July 2024

Time-resolved macromolecular serial crystallography

Oskar Aurelius, Shibom Basu, Gisela Brändé, Arwen Pearson, Daniele de Sanctis

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview The advent of serial crystallography at free electron laser sources and the following adaptation of these methods at 3rd and 4th generation synchrotrons have opened new possibilities to perform room temperature time... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview The advent of serial crystallography at free electron laser sources and the following adaptation of these methods at 3rd and 4th generation synchrotrons have opened new possibilities to perform room temperature time relolved studies in macromolecular crystallography. This practical course aims to teach participants know-how of time-resolved serial crystallography and to illustrate the entire pipeline from sample-preparation to a 3D molecular movie. Lectures and practical sessions will be delivered to explain how to prepare micro-crystals of biomolecules, how to use various sample delivery methods for serial crystallography, to design time-resolved experiments, to collect data, and to process serial crystallographic data....

15 July - 19 July 2024

Proteomics bioinformatics

Sophie Spencer

This course provides hands on training in the basics of mass spectrometry MS and proteomics bioinformatics Participants will receive training on how to use search engines and post processing software quantitative approaches MS data repositories the use of public databases for protein analysis annotation of subsequent protein lists and incorporation of information from molecular interaction and pathway databases This course is currently under development please check back again soon for further details... This course provides hands-on training in the basics of mass spectrometry (MS) and proteomics bioinformatics. Participants will receive training on how to use search engines and post-processing software, quantitative approaches, MS data repositories, the use of public databases for protein analysis, annotation of subsequent protein lists, and incorporation of information from molecular interaction and pathway databases. This course is currently under development, please check back again soon for further details.

19 August - 26 August 2024

Advances in cryo-electron microscopy and 3D image processing

Julia Mahamid, Sebastian Eustermann, Simone Mattei, Lori Passmore, Henning Stahlberg

This course provides the theoretical and practical foundations of advanced cryoEM techniques from sample preparation to data collection to image processing... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Cryo-electron microscopy (cryoEM) has become the method of choice for determining atomic-level structures of large and flexible macromolecular assemblies that are notoriously difficult to study by other techniques. In addition, it has unique capabilities for obtaining structural information in situ, within complex (cellular) environments, and to deal with biologically heterogeneous samples. With the advent of the cryoEM “resolution revolution”, the method has undergone a tremendous growth in user base. Yet, the underlying methods are complex and under constant development. Therefore, in depth advanced training is essential to ensure future generations can adapt emerging technologies to expand into new areas of biological...

24 August - 27 August 2024

Transcription and chromatin

Shelley Berger, Eileen Furlong, Luca Giorgetti, Jürg Müller

The meeting brings together leading experts covering all aspects of transcription including cis regulatory function long range regulation 3 dimensional looping the basal transcriptional machinery RNA polymerase regulation and function nucleosome positioning chromatin modifications chromatin remodelling and epigenetic inheritance of transcriptional silencing... OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview The EMBL Transcription and Chromatin meeting has a long-standing tradition in shaping the field of transcriptional regulation. The meeting brings together leading experts covering all aspects of transcription including cis-regulatory function, long range regulation, 3-dimensional looping, the basal transcriptional machinery, RNA polymerase regulation and function, nucleosome positioning, chromatin modifications, chromatin remodelling, and epigenetic inheritance of transcriptional silencing. The meeting contains many talks selected from the abstracts that are interspersed with invited speakers, discussing the latest...

1 September - 10 September 2024

Current methods in cell biology

Niccolò Banterle, Beth Cimini, Simone Koehler

The course aims to expose researchers with different backgrounds to the diverse cutting edge methods developed for cell biology to showcase how integrated approaches can address the current big questions in cell biology... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview The aim of the “Current methods in Cell Biology” course is to teach participants to use modern cell biology to answer outstanding questions at the frontiers of cell biology. Following the long-standing tradition of the course, the entire faculty of the Cell Biology and Biophysics Unit of EMBL will teach the course. The expertise of the EMBL faculty will be complemented by external experts. The course will thus teach participants a comprehensive palette of the latest techniques. The hands-on experience gained in the course will provide the participants the knowledge on how to combine different state-of the art tools to obtain the orthogonal information necessary to disentangle key biological questions in the...

1 September - 6 September 2024

Genome engineering: CRISPR/Cas in cells and mice

Vladimir Benes, Neil Humphreys, Birgit Koch, Elisabeth Zielonka

OverviewSponsorsMedia kit Overview Course overview This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR Cas9 system Participants will learn design of CRISPR targets using bioinformatics tools generation of gene knock outs knock ins and target validation using the most current technologies The... OverviewSponsorsMedia kit Overview Course overview This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR/Cas9 system. Participants will learn design of CRISPR targets using bioinformatics tools, generation of gene knock-outs/knock-ins, and target validation using the most current technologies. The course will be split into two groups (mammalian cells OR mice) based on participants’ expertise. Please note that all participants are expected to engage in all sessions. Participants should plan for approximately 1 hour extra per day for self paced learning modules. Audience This course is aimed at researchers who are familiar with basic molecular and cell biology techniques and who want to learn how to create an engineered mammalian cell line or mouse model using the most recent and...

2 September - 5 September 2024

Imaging mouse development

Jan Ellenberg, Kate McDole, Isabel Espinosa Medina, Robert Prevedel, Shankar Srinivas

OverviewSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview This workshop aims to bring together and help establish an emerging community with the common goal of four dimensional... OverviewSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview This workshop aims to bring together and help establish an emerging community with the common goal of four dimensional reconstruction of mammalian development. A number of long­standing questions surrounding the early development of mammals have been inaccessible to molecular research due to technical limitations and poor physical accessibility of these processes. How is the body plan established in the early embryo? How is morphogenesis coordinated with lineage specification? The recent revolutions in advanced light microscopy and bioimage informatics have opened up completely new avenues to address these questions and make...

9 September - 12 September 2024

Chemical biology 2024

Yimon Aye, Bryan Dickinson, Maja Köhn

OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview The conference sets the stage for the dissemination and exchange of new developments in diverse hot fields within... OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview The conference sets the stage for the dissemination and exchange of new developments in diverse, hot fields within chemical biology. It is the largest and longest standing conference in the field, being a platform for inspiration, collaboration and networking for researchers in academia and industry. We aim to provide the possibility for every chemical biologist to meet and discuss with peers on topics ranging from tool development to biological applications, from computational drug design to synthetic chemistry. Session topics Drug and target discovery Genetically-encoded biosensors Structure-function relations in...

15 September - 22 September 2024

Synthetic biology in action: engineering synthetic systems

Sven Panke, Vitor Pinheiro, Karen Polizzi, Nico Claassens, Velia Siciliano

OverviewSponsorsMedia kit Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Synthetic Biology SynBio has become a rapidly developing area for tackling a large number of challenges in life science research This is due to a combination of foundational advances in technologies such as... OverviewSponsorsMedia kit Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Synthetic Biology (SynBio) has become a rapidly developing area for tackling a large number of challenges in life science research. This is due to a combination of foundational advances in technologies such as large-scale DNA synthesis and new methods that allow integrating such raw synthesis power into engineering approaches, including genome wide small RNA regulation, dCas9-based regulation, and multiplexed genome engineering. Such fresh approaches fuel new types of biotechnological applications with immense impact on both fundamental science and society. This course will provide the best and most exciting novelties in the field and focus on exploiting tools and concepts of SynBio for multi-scale engineering...

17 September - 20 September 2024

Reconstructing the human past: using ancient and modern genomics

Johannes Krause, Ida Moltke, Maanasa Raghavan, Pontus Skoglund

Combining genome wide data from ancient and modern populations opens new windows into the past Population scale sequencing projects investigating past and present human diversity have already provided us with extraordinary insights into patterns of human variation and mobility through time and space This meeting will involve scientists from population genetics bioinformatics microbiology anthropology archaeology and history and will strengthen future interactions in this young research field that is already changing the way we think about our past and will shape how we study genetic variation in the future... OverviewSpeakersSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview Combining genome-wide data from ancient and modern populations opens new windows into the past. Population-scale sequencing projects investigating past and present human diversity have provided us with extraordinary insights into patterns of human variation and mobility through time and space. The integration of archaeological evidence and historical records with genomic data elucidates aspects of human history and the cultural evolution of past societies. Additionally, genome-wide data from archaic human remains, such as Neandertals and Denisovans, enable investigations of human evolution in action and provide direct...

23 September - 27 September 2024

Metagenomics bioinformatics at MGnify

Meredith Willmott

Learn about the tools processes and analysis approaches used by MGnify in the field of genome resolved metagenomics This course will cover the use of publicly available resources to manage share analyse and interpret metagenomics data focussing primarily on the assembly based approaches used in MGnify analysis The delivered content will involve participants learning via live lectures and presentations followed by live Q As with the trainers Practical experience will be developed in group activities and in computational exercises run using containerised tools on our training infrastructure This course is currently under development please check back again soon for further details... Learn about the tools, processes, and analysis approaches used by MGnify in the field of genome-resolved metagenomics. This course will cover the use of publicly available resources to manage, share, analyse, and interpret metagenomics data, focussing primarily on the assembly-based approaches used in MGnify analysis. The delivered content will involve participants learning via live lectures and presentations, followed by live Q&As with the trainers. Practical experience will be developed in group activities and in computational exercises run using containerised tools on our training infrastructure. This course is currently under development, please check back again soon for further details.

23 September - 27 September 2024

Single-cell RNA-seq analysis with Python

Juanita Riveros

This course covers the analysis of single cell RNA sequencing scRNA seq data using Python and command line tools Participants will be guided through droplet based scRNA seq analysis pipelines from raw reads to cell clusters You will explore and interpret single cell RNA seq data using Python as well as the Single Cell Expression Atlas Finally you will put their knowledge into practice through a group challenge on the last day Please note that you will not analyse your own data as part of the course There will however be ample opportunity to discuss your research and ideas with other course participants and trainers This course is currently under development please check back again soon for further details... This course covers the analysis of single-cell RNA sequencing (scRNA-seq) data using Python and command line tools. Participants will be guided through droplet-based scRNA-seq analysis pipelines from raw reads to cell clusters. You will explore and interpret single-cell RNA seq data using Python as well as the Single Cell Expression Atlas. Finally, you will put their knowledge into practice through a group challenge on the last day. Please note that you will not analyse your own data as part of the course. There will, however, be ample opportunity to discuss your research and ideas with other course participants and trainers. This course is currently under development, please check back again soon for further details.

30 September - 3 October 2024

Defining and defeating metastasis

Eduard Batlle, Johanna Joyce, Daniel Klimmeck, Joan Massagué, Samra Turajlic

This symposium will bring together researchers from diverse fields to enhance our understanding of the dissemination and metastatic colonisation of tumour cells It will provide a unique opportunity for interdisciplinary exchange on current approaches and future collaborations on metastasis and its therapeutic challenges... OverviewSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview This, the second edition of this symposium, will cover emerging key concepts of latent metastasis and dissemination of tumor cells including evolution and genetic diversity of metastasis, circulating tumor cells, stemness, dormancy and stromal reprogramming, transcriptional and epigenetic control, motility and invasive signaling, metastatic heterogeneity, EMT and plasticity, immune evasion and metabolic adaptations. The meeting will provide unique interdisciplinary exchange on current approaches and future collaborations on metastasis and its therapeutic challenges. Metastasis research is a nexus for several of the most...

8 October - 11 October 2024

Molecular mechanisms in evolution and ecology

Gilles Fischer, Jordi van Gestel, Kimberley Kline, Sara Mitri, Antonis Rokas

This conference series has become known for exploring yeasts as models to study questions of general relevance to evolution and ecology Experts will speak on a range of topics including evolution theory ecology genetics cell biology genomics systems biology metabolic modelling and engineering... OverviewSpeakersSponsorsMedia Kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview This conference series has become known for exploring yeasts as models to study questions of general relevance to evolution and ecology. Experts will speak on a range of topics, including evolution theory, ecology, genetics, cell biology, genomics, systems biology, metabolic modelling, and engineering. What past participants say about the conference “An incredibly interesting and well-organised event, not only from the scientific side but also on the technical part. As expected from other editions of the meeting, the science was amazing and very variegated. Kudos for the organisation and for the unusually high...

15 October - 18 October 2024

The complex life of RNA

Elena Conti, Olivier Duss, Torben Heick Jensen, Karla Neugebauer

This symposium brings together leaders in the RNA field post docs and students with the aim of disseminating and discussing the most recent findings of information added to mRNAs The programme will include among others sessions on transcription RNA processing and modification mRNA export and localisation mRNA surveillance and decay translation and the control of mRNA expression by microRNAs... OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview Before the genetic information stored in DNA can be used to direct cell growth and metabolism, it has to be transferred into RNA. Messenger RNAs (mRNAs) that code for proteins and noncoding RNAs are key components in the transmission of genetic information in all life forms – from viruses to complex mammalian organisms. Exciting recent findings now reveal a new layer of information added to RNAs in the form of chemical marks (the epitranscriptome) that play a critical role in gene expression control. Following the great success of the 2022 edition of this long-standing symposium,...

21 October - 26 October 2024

Imaging down to single-molecule resolution: STED & MINFLUX nanoscopy

Marko Lampe, Christian Wurm, Timo Zimmermann

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview The course aims to train biological microscopy users in two forms of super resolution light microscopy Stimulated Emission Depletion STED Microscopy and Minimal photon fluxes MINFLUX Both techniques require... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview The course aims to train biological microscopy users in two forms of super-resolution light microscopy, Stimulated Emission Depletion (STED) Microscopy and Minimal photon fluxes (MINFLUX). Both techniques require technical understanding of the process and instrumentation, training in the method specific requirements of sample preparation and in the acquisition procedures and an understanding of how to further analyze the acquired image data. It is the aim of the course to provide the tools for the successful execution of nanoscopy experiments with these two distinct methods. The course should also allow the participants to understand the specific benefits of the different techniques and thus help them in choosing the...

29 October - 31 October 2024

Managing a bioinformatics core facility

Jane Reynolds

This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL EBI s service teams and from each other These facilities play an essential role in enabling research in the molecular life sciences The landscape is constantly evolving as new research tools emerge as experiments become increasingly data intensive and as their clients experimental researchers become more exposed to the power of data driven biology This course will allow participants to share experiences discuss challenges and solutions that they face and plan ways to cope with the ever changing demands raised by the molecular life science field It will include sessions to learn from bioinformatics service providers hear how others have tackled common problems and work together to design core services resource them and measure their impact This course is currently under development please check back again soon for further details... This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL-EBI’s service teams, and from each other. These facilities play an essential role in enabling research in the molecular life sciences. The landscape is constantly evolving as new research tools emerge, as experiments become increasingly data-intensive, and as their clients – experimental researchers – become more exposed to the power of data-driven biology. This course will allow participants to share experiences, discuss challenges and solutions that they face, and plan ways to cope with the ever-changing demands raised by the molecular life science field. It will include sessions to learn from bioinformatics service providers, hear how others have tackled common problems, and work together to design core services, resource them, and measure their impact. This course is...

4 November - 8 November 2024

Structural bioinformatics

Juanita Riveros

This course provides a guide to the commonly used methods and tools in structural bioinformatics to analyse and interpret experimentally determined and AI predicted macromolecular structure data Structural biology determining the three dimensional shapes of biomacromolecules and their complexes can tell us a lot about how these molecules function and the roles they play within a cell Data derived from structure determination experiments and Artificial Intelligence AI assisted structure prediction enables life science researchers to address a wide variety of questions This course explores bioinformatics data resources and tools for the investigation analysis and interpretation of both experimentally determined and predicted biomacromolecular structures It will focus on how best to analyse and interpret available structural data to gain useful information given specific research contexts The course content will also cover predicting function and exploring interactions with other macromolecules This course is currently under development please check back again soon for further details... This course provides a guide to the commonly used methods and tools in structural bioinformatics to analyse and interpret experimentally determined and AI-predicted macromolecular structure data. Structural biology, determining the three-dimensional shapes of biomacromolecules and their complexes, can tell us a lot about how these molecules function and the roles they play within a cell. Data derived from structure determination experiments and Artificial Intelligence (AI)-assisted structure prediction enables life-science researchers to address a wide variety of questions.   This course explores bioinformatics data resources and tools for the investigation, analysis, and interpretation of both experimentally determined and predicted biomacromolecular structures. It will focus on how best to analyse and interpret available structural data to gain useful information given...

4 November - 8 November 2024

The fundamentals of high-end cell sorting

Beata Ramasz, Diana Ordonez

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview This course includes a robust theoretical part on the fundamentals of cell sorting delivered by world leading experts and practical sessions on using standard cuvette sorters In addition the course program will include... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview This course includes a robust theoretical part on the fundamentals of cell sorting delivered by world-leading experts and practical sessions on using standard cuvette sorters. In addition, the course program will include principles, applications, and hands-on sessions on Image Cell Sorting (ICS), allowing attendees to get in touch with this exciting technology! Audience The course is intended for Ph.D. students and postdocs who are starting to use or already using cell sorting in their research projects. Applicants with previous active knowledge of basic principles of flow cytometry and regular use of flow cytometers in daily research will profit most from the course content. What past participants say about the course...

5 November - 8 November 2024

DNA replication: from basic biology to disease

Anja Groth, Thanos Halazonetis, Helle Ulrich

OverviewSponsorsAboutMedia Kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Symposium overview There has been tremendous progress in the past few years regarding our understanding of DNA replication in... OverviewSponsorsAboutMedia Kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview There has been tremendous progress in the past few years regarding our understanding of DNA replication in eukaryotes, both yeast and mammals. Many important questions in the field are poised to be answered within the next decade. These include understanding DNA replication at the biochemical and three-dimensional protein structure levels. In addition, studies using high throughput technologies at the cellular and organismal levels are poised to answer how accurate replication of the genome is ensured by controlling origin firing in space and time. Session topics DNA replication stress DNA replication biology...

14 November - 15 November 2024

The next generation in infection biology

Maria Bernabeu, Jan Kosinski, Eva Kowalinski, John Lees, Lizette de Paula, Nassos Typas

Infectious diseases are among the most prevalent causes of human illness and death in the world Pathogens infect humans and all life forms on Earth being able to cross species barriers thereby adversely impacting human and planetary health Fundamental research in Infection Biology is urgently needed to find therapies for longstanding and emerging infectious diseases... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. After the success of the virtual 2022 edition, this conference will return in a virtual format. Conference overview Infectious diseases are among the most prevalent causes of human illness and death in the world. Pathogens infect humans and all life forms on Earth, being able to cross species barriers, thereby adversely impacting human and planetary health. Fundamental research in Infection Biology is urgently needed to find therapies for longstanding and emerging infectious diseases.   The EMBL Conference ‘The next generation in infection biology’ is a platform for late-stage postdoctoral scientists in the field of infection biology to present their work and connect with the leading European institutions in...

17 November - 22 November 2024

Humanised mice: immunotherapy and regenerative medicine

Karl-Dimiter Bissig, Ernesto de la Cueva Bueno, Christian Münz, Jan Jakob Schuringa, Lenny Shultz, Brian Soper, Renata Stripeke, Anja Wege

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Humanized mouse engraftment models human immune system and or human tissue are an integral part of basic and translational research for the understanding of human diseases and for development of new therapies The... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Humanized mouse engraftment models (human immune system and/or human tissue) are an integral part of basic and translational research for the understanding of human diseases and for development of new therapies. The Ebola Virus outbreak has demonstrated the relevance of humanized mouse models for the understanding of emerging diseases and testing new medicines. The same can apply for the Coronavirus (COVID-19) pandemic. “Big pharma” and biotech companies include humanized mice in their pre-clinical development portfolio to test efficacy and safety of anti-cancer drugs. These platforms provide researchers and drug developers with human specific targets, physiological pathways and mechanisms of disease not found in...

18 November - 22 November 2024

Plant genomes: from data to discovery

Sophie Spencer

This course is currently under development please check back again soon for further details... This course is currently under development, please check back again soon for further details.

18 November - 22 November 2024

Genome bioinformatics: from short- to long-read sequencing

Meredith Willmott

A guide to the technology analysis workflows tools and resources for next generation sequencing data analysis This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data The main focus will be on introducing sequence informatics re sequencing differences between short and long read sequencing and variant calling during the analysis of higher eukaryotes with an emphasis on human genetic research Throughout the week more advanced topics will introduce the creation of pipelines automation and the scaling up of analysis experiments Practical sessions will be run on datasets prepared by the trainers not on personal research data Participants will learn how to process these training datasets and to apply appropriate statistical methods in their analyses This course is currently under development please check back again soon for further details... A guide to the technology, analysis workflows, tools, and resources for next-generation sequencing data analysis. This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data. The main focus will be on introducing sequence informatics, re-sequencing, differences between short- and long-read sequencing, and variant calling during the analysis of higher-eukaryotes, with an emphasis on human genetic research. Throughout the week, more advanced topics will introduce the creation of pipelines, automation, and the scaling-up of analysis experiments. Practical sessions will be run on datasets prepared by the trainers, not on personal research data. Participants will learn how to process these training datasets and to apply appropriate statistical methods in their analyses....

19 November - 22 November 2024

Quantitative biology to molecular mechanisms

Lacra Bintu, Hartland Jackson, Arnaud Krebs, Tineke Lenstra, Mikhail Savitski

OverviewSponsors Overview A funding application to EMBO is in progress for this event This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview Genomics proteomics and quantitative imaging are rapidly moving... OverviewSponsors Overview A funding application to EMBO is in progress for this event. This conference will take place at EMBL Heidelberg, with the option to attend virtually. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview Genomics, proteomics and quantitative imaging are rapidly moving fields with technological innovations and new biological insights occurring on an almost monthly basis. For example, mass spectrometry-based proteomics is now able to quantitatively assess close to 80% of the proteome which can nowadays be obtained from very low cell numbers. An even greater jump in sensitivity has recently revolutionized genomics with the rapid spread of measurements at the resolution of single molecule and single cells. Development of new methods and instruments has led to the emergence...

3 December - 6 December 2024

Hands-on course for sample preparation and data analysis in proteomics

Mandy Rettel, Mikhail Savitski, Frank Stein

OverviewSponsors Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview The course will give an introduction to the theoretical aspects of the analysis of proteins peptides by mass spectrometry Participants will get hands on experience in sample preparation for a quantitative comparison across... OverviewSponsors Overview Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview The course will give an introduction to the theoretical aspects of the analysis of proteins/peptides by mass spectrometry. Participants will get hands-on experience in sample preparation for a quantitative comparison across samples and perform an in-solution digest using Single-Pot Solid-Phase-enhanced Sample Preparation (SP3) (Hughes et al., Molecular Systems Biology, 2014) and tandem mass tag labelling (TMT). The SP3 technology was developed at EMBL. It enables scientists with a proteomics sample preparation method from nearly any starting buffer conditions (e.g. Laemmli buffer).Participants will measure their own produced samples using LC-MS/MS and will learn in a session focused on the bioinformatics analysis how the...