29 November - 2 December 2022

Protein quality control for downstream processes

Karine Lapouge, Kim Remans

The course will focus on the importance of protein quality control and introduce methodologies that can be used to assess and improve sample quality... OverviewSpeakers ProgrammePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview Purified proteins are used in various types of scientific experiments and fields. For example, in structural biology insights into the functional mechanisms can be obtained by elucidating the 3D molecular structure of proteins and protein complexes using technologies such as X-ray crystallography, cryo-EM and NMR. In biochemistry and biophysics, interactions with other proteins, nucleic acids and small molecules can be studied by determining affinities and specificities. Proteins can function as antigens to generate specific antibodies or as reagents in cell biology experiments. Furthermore, recombinant proteins can be used as tool molecules in genomics, chemical biology and microscopy assays....

30 November 2022

Biocuration Q&A session

This Q A question and answer webinar will provide an opportunity for anyone who has completed Biocuration A curated set of EMBL EBI online courses to join some of EMBL EBI s experts and ask their own questions This session will focus on the role of biocuration in maintaining life science data and general data management It will also highlight the application of programming and text mining in biocuration The questions covered during the Q A webinar will depend on those asked by attendees however we will likely cover topics such as Biocuration principles Data management of biological data and open data Programming and text mining for biocurators Finding the right EMBL EBI resource for accessing or submitting data If you have a question now please submit it using the registration form otherwise you can ask your question live at the webinar or just join to hear answers to questions that others submit... This Q&A (question and answer) webinar will provide an opportunity for anyone who has completed ‘Biocuration: A curated set of EMBL-EBI online courses’ to join some of EMBL-EBI's experts and ask their own questions. This session will focus on the role of biocuration in maintaining life science data and general data management. It will also highlight the application of programming and text mining in biocuration. The questions covered during the Q&A webinar will depend on those asked by attendees, however we will likely cover topics such as: Biocuration principles Data management of biological data and open data Programming and text mining for biocurators Finding the right EMBL-EBI resource for accessing or submitting data If you have a question now, please submit it using the registration form, otherwise you can ask your question live at the webinar, or just join to hear answers...

7 December - 9 December 2022

The spectra of life: dimensional breadth in biological research

2022 EMBL PhD Symposium Organising Committee

Join us for the 24th Anniversary of the annual EMBL PhD Symposium Since its conception in 1999 the EMBL PhD Symposium has evolved into a highly respected scientific meeting connecting young researchers and high profile scientists alike...

7 December 2022

Chemical biology Q&A session

This Q A question and answer webinar will provide an opportunity for anyone who has completed Chemical biology A curated set of EMBL EBI online courses to join some of EMBL EBI s experts and ask their own questions This session will focus on exploring chemical compounds or drug molecules finding drug targets and target disease associations using resources such as ChEMBL and Open Targets The questions covered during the Q A webinar will depend on those asked by attendees however we will likely cover topics such as Curation and maintenance of chemical compounds database Chemogenomics Finding data about interactions between drugs or drug like molecules and their targets Drug discovery and target identification If you have a question now please submit it using the registration form otherwise you can ask your question live at the webinar or just join to hear answers to questions that others submit... This Q&A (question and answer) webinar will provide an opportunity for anyone who has completed ‘Chemical biology: A curated set of EMBL-EBI online courses’ to join some of EMBL-EBI's experts and ask their own questions. This session will focus on exploring chemical compounds or drug molecules, finding drug targets and target disease associations using resources such as ChEMBL and Open Targets. The questions covered during the Q&A webinar will depend on those asked by attendees, however we will likely cover topics such as: Curation and maintenance of chemical compounds database Chemogenomics Finding data about interactions between drugs or drug-like molecules and their targets Drug discovery and target identification If you have a question now, please submit it using the registration form, otherwise you can ask your question live at the webinar, or just join to hear answers to...

8 December 2022

Automated annotation in UniProt

Pedro Raposo

UniProt is a high quality comprehensive protein resource in which the core activity is the expert review and annotation of proteins where the function has been experimentally investigated At the same time the UniProt database contains large numbers of proteins which are predicted to exist from gene models but which do not have associated experimental evidence indicating their function UniProt commits significant resources to developing computational methods for functional annotation of these predicted proteins based on the data in entries that have gone through the expert review process We will describe the two main automated annotation systems currently in use First UniRule which is an established UniProt system in which curators manually develop rules for annotation Second ARBA Association Rule Based Annotator which is a multi class learning system which uses rule mining techniques to generate concise annotation models ARBA employs a data exclusion algorithm that censors data not suitable for computational annotation and generates human readable rules for each UniProt release As part of our interest in engaging with the machine learning community we will also introduce the contribution of a Neural Logic Machine NLM based prediction from Google which annotates proteins which have uncharacterized names We will also introduce UniFIRE an open source software that enables researchers to annotate their own protein dataset by using the above mentioned annotation systems In order to provide an easy and straightforward way to download and set up this tool we have containerised UniFIRE together with all its dependencies and the latest set of UniRule and ARBA rules In this webinar we will show how to create functional predictions for protein sequences by using this container image... UniProt is a high quality, comprehensive protein resource in which the core activity is the expert review and annotation of proteins where the function has been experimentally investigated. At the same time, the UniProt database contains large numbers of proteins which are predicted to exist from gene models, but which do not have associated experimental evidence indicating their function. UniProt commits significant resources to developing computational methods for functional annotation of these predicted proteins based on the data in entries that have gone through the expert review process. We will describe the two main automated annotation systems currently in use. First, UniRule, which is an established UniProt system in which curators manually develop rules for annotation. Second, ARBA (Association-Rule-Based Annotator), which is a multi-class learning system which uses rule mining...

14 December 2022

Exploring somatic mutations in cancer with the COSMIC database and analysis tools

Rebecca White, Steven Jupe

COSMIC the Catalogue of Somatic Mutations in Cancer helps the global cancer research community conduct their science faster and better by presenting easy to understand streamlined and quality filtered data on cancer mutations We do this by providing high quality datasets curated by experts over the course of 18 years standardising our data into easily integrable formats and innovating with collaborators to provide analysis tools and actionable insights With 23 million genomic variants expertly curated from nearly 30 000 publications covering 6 800 precise forms of human cancer COSMIC is the world s largest manually curated database of somatic mutation information relating to human cancers This vast breadth and depth of high quality data is the gold standard relied upon by academic research and industry alike including pharmaceutical drug discovery and biotech companies This webinar will provide an introduction to COSMIC our process and demonstrate the vast range of data and analyses available via our multiple tools and projects We will focus particularly on two of our newer projects Cancer Mutation Census and Actionability which will be freely available for non commercial download as of 29 November 2022 We will also provide an opportunity for questions and hope that by the end of the webinar you will feel confident in exploring COSMIC s tools and understand how they can add value to your work... COSMIC (the Catalogue of Somatic Mutations in Cancer) helps the global cancer research community conduct their science faster and better by presenting easy to understand, streamlined, and quality filtered data on cancer mutations. We do this by providing high quality datasets curated by experts over the course of 18 years, standardising our data into easily-integrable formats, and innovating with collaborators to provide analysis tools and actionable insights. With 23 million genomic variants, expertly curated from nearly 30,000 publications, covering 6,800 precise forms of human cancer, COSMIC is the world’s largest manually curated database of somatic mutation information relating to human cancers. This vast breadth and depth of high quality data is the gold standard, relied upon by academic research and industry alike, including pharmaceutical, drug discovery and biotech companies....

15 December 2022

Introducing PerMedCoE Building Blocks and Workflows to streamline biological analysis pipelines

Jesse Harrison

Analysing biological datasets is nearly always a multi step process involving many interconnected stages Even so the lack of transparent approaches to managing complex data analysis pipelines remains a common challenge in the life sciences Another limiting factor is that completing such pipelines often requires in depth knowledge of many data analysis tools and programming languages There is therefore a continued need for methodologies that make complex biological data analysis pipelines easier to implement This webinar will present some of the main practical ways through which PerMedCoE seeks to make data analysis pipelines more manageable and accessible to researchers In particular the webinar will provide an overview of how the project addresses many biological use cases using a single shared approach in which semi automated workflows are constructed using purpose designed building blocks About the speaker Dr Jesse Harrison is a Senior Data Scientist and Project Manager at CSC IT Center for Science Ltd where he currently leads the Horizon EU BioDT project His other tasks have included R environment design maintenance and support on CSC computing platforms bioinformatics tool development and teaching Prior to joining CSC in 2019 Jesse held postdoctoral positions in microbial ecology astrobiology and environmental chemistry at the universities of Helsinki Turku Vienna and Edinburgh 2012 2019... Analysing biological datasets is nearly always a multi-step process involving many interconnected stages. Even so, the lack of transparent approaches to managing complex data analysis pipelines remains a common challenge in the life sciences. Another limiting factor is that completing such pipelines often requires in-depth knowledge of many data analysis tools and programming languages. There is, therefore, a continued need for methodologies that make complex biological data analysis pipelines easier to implement. This webinar will present some of the main practical ways through which PerMedCoE seeks to make data analysis pipelines more manageable and accessible to researchers. In particular, the webinar will provide an overview of how the project addresses many biological use cases using a single, shared approach in which semi-automated workflows are constructed using purpose-designed...

18 January 2023

Introduction to EMBL-EBI for teachers and trainers

Anna Swan, Benjamin Moore, Mariia Levchenko

EMBL EBI is the home of the world s most comprehensive range of freely available molecular databases and resources Our resources help researchers share and analyse data and perform complex queries in many different ways EMBL EBI also provides open access on demand training materials which are usable by teachers lecturers or trainers for teaching bioinformatics methods and tools During this webinar we will provide an overview of the range of EMBL EBI data resources and the role of EMBL EBI in making data open and accessible and an introduction to the training and materials EMBL EBI provides We will finish the webinar with a panel discussion to highlight the support for teachers that EMBL EBI Training provides which includes a large variety of free to access training material content This will help you identify specific topics in bioinformatics or EMBL EBI databases and tools the on demand training available and how you can access and adapt the training materials in your own teaching session Meet the panel Anna Swan Anna is a scientific training officer for e Learning at EMBL EBI She has a PhD in Bioinformatics from the University of Nottingham where she focused on the bioinformatic identification of biomarkers of osteoarthritis Following her PhD Anna worked as a medical writer spanning many therapeutic areas and working both on promotional and educational content for clinicians She has also worked as a data wrangler for the International Mouse Phenotyping Consortium at the project s data coordination centre based in the Medical Research Council s Harwell Institute Benjamin Moore Ben is Ensembl outreach manager and he organises workshops and other training events for Ensembl resources Ben has a PhD in Biological Sciences from the MRC Laboratory of Molecular Biology at the University of Cambridge Maria Levchenko Maria Levchenko is a Community Manager for Europe PMC an open literature database for life sciences developed by the European Bioinformatics Institute EMBL EBI Europe PMC indexes over 300 000 preprints abstracts and full text COVID 19 preprints from 20 life sciences preprint servers alongside published journal articles Before joining Europe PMC Maria obtained a PhD in Biochemistry from Georg August University in Goettingen Germany and has worked with the European Research Council ERC Executive Agency Maria is passionate about innovative solutions in scholarly communications that help the research community to advance scientific knowledge... EMBL-EBI is the home of the world's most comprehensive range of freely available molecular databases and resources. Our resources help researchers share and analyse data and perform complex queries in many different ways. EMBL-EBI also provides open-access on-demand training materials which are usable by teachers, lecturers or trainers for teaching bioinformatics methods and tools. During this webinar we will provide an overview of the range of EMBL-EBI data resources and the role of EMBL-EBI in making data open and accessible, and an introduction to the training and materials EMBL-EBI provides.  We will finish the webinar with a panel discussion to highlight the support for teachers that EMBL-EBI Training provides, which includes a large variety of free to access training material content. This will help you identify specific topics in bioinformatics or EMBL-EBI databases and...

24 January - 27 January 2023

Computing skills for reproducible research: data carpentry

Renato Alves, Lisanna Paladin, Fotis Psomopoulos, Christian Schudoma

The course is aimed at graduate students and other researchers in the life sciences who would like to learn good practices in data management and analysis The course is ideally suited to students without prior experience in computational research but some familiarity with working with tabular data on a computer is welcome... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview The missing step between data collection and research progress is a lack of training for researchers in crucial skills for effectively managing and analysing large amounts of data. This hands-on workshop teaches researchers the fundamental data skills they need to conduct their work and provides high-quality, domain-specific training covering the full lifecycle of data-driven research. The domain-specific approach allows participants to tailor the data, content, and tools to reflect the specific data and analysis needs of different areas. Audience The course is aimed at graduate students and other researchers in the life sciences who would like to learn good practices in project and data...

31 January - 1 February 2023

EuroFAANG GENE-SWitCH workshop: utilisation of GENE-SWitCH data in Ensembl and beyond

Shereen Pethania

This one and a half day workshop will provide detailed training on the utilisation of the wealth of data generated by the EuroFAANG GENE SWitCH project that is delivering new underpinning knowledge for pig and chicken agriculture The workshop will primarily focus on the comprehensive and integrated annotation of the chicken and pig genomes by the Ensembl Genome Browser The course will also include a deeper dive from the Ensembl analysis teams into gene annotation and regulation and demonstrations of the specific analyses and genomic prediction models generated by GENE SWitCH researchers Additional information The course fee is inclusive of one night of accommodation and catering including dinner We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Hybrid options are not currently available Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website... This one and a half day workshop will provide detailed training on the utilisation of the wealth of data generated by the EuroFAANG GENE-SWitCH project that is delivering new underpinning knowledge for pig and chicken agriculture. The workshop will primarily focus on the comprehensive and integrated annotation of the chicken and pig genomes by the Ensembl Genome Browser. The course will also include a deeper dive from the Ensembl analysis teams into gene annotation and regulation, and demonstrations of the specific analyses and genomic prediction models generated by GENE-SWitCH researchers. Additional information The course fee is inclusive of one night of accommodation and catering, including dinner. We plan to deliver this course in an in-person manner onsite at our training suite at EMBL-EBI, Hinxton.  Hybrid options are not currently available. Please be aware that we are...

6 February - 10 February 2023

Single-cell RNA-seq analysis using Galaxy

Jane Reynolds

This course utilises Galaxy pipelines an online open access resource that allows even the most computer phobic bench scientists to analyse their biological data Participants will be guided through the droplet based scRNA seq analysis pipelines from raw reads to trajectories Please note that although participants will not be able to use their own data during the course practicals there will be ample time to discuss their research and ideas with both course participants and trainers As part of this participants will present posters on their research topics Virtual course This course will now be held virtually it was previously advertised as an on site course Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Trainers will be available to assist answer questions and provide further explanations during the course... This course utilises Galaxy pipelines, an online open-access resource that allows even the most computer-phobic bench scientists to analyse their biological data. Participants will be guided through the droplet-based scRNA-seq analysis pipelines from raw reads to trajectories. Please note that although participants will not be able to use their own data during the course practicals, there will be ample time to discuss their research and ideas with both course participants and trainers.  As part of this, participants will present posters on their research topics. Virtual course This course will now be held virtually, it was previously advertised as an on-site course. Hybrid options are not currently available. We reserve the right to change the format of this course or cancel it, due to the ongoing coronavirus pandemic. Participants will learn via a mix of pre-recorded lectures,...

8 February - 11 February 2023

In situ structural biology: from cryo-EM to multi-scale modelling

Martin Beck, Jan Kosinski, Julia Mahamid, Suliana Manley

There is an increasing awareness that mechanistic structural information on molecular machines is ideally generated within the context of intact cells in order to fully grasp how they function in a complex native environment Recent technological advances have nurtured the development of such in situ structural biology approaches in several disciplines including cryo EM mass spectrometry super resolution microscopy NMR computational modelling and others This conference will bring together experts and early stage researchers from these separate fields... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Workshop overview There is an increasing awareness that mechanistic structural information on molecular machines is ideally generated within the context of intact cells in order to fully grasp how they function in a complex native environment. Recent technological advances have nurtured the development of such in situ structural biology approaches in several disciplines, including cryo-EM, mass spectrometry, super-resolution microscopy, NMR, computational modelling and others. This conference will bring together experts and early stage researchers from the separate fields to provide a platform for structural...

12 February - 17 February 2023

In situ CLEM at room temperature and in cryo

Ori Avinoam, Rachel Mellwig, Martin Schorb

Correlative Light and Electron Microscopy CLEM allows precise localisation of an event of interest within cells and tissues During this course we will focus on a specific method that has been developed at EMBL that enables the location of fluorescent proteins with high accuracy at the ultrastructural level The course will cover both the theory and practicals of high precision CLEM as well as opportunities to discuss their research with CLEM experts and receive practical and troubleshooting advice... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview Correlative Light and Electron Microscopy (CLEM) allows precise localisation of an event of interest within cells and tissues. During this course, we will focus on a specific method that has been developed at EMBL that enables the localisation of fluorescent proteins with high accuracy at the ultrastructural level. The course will cover both the theory and practicals of high precision CLEM, as well as opportunities to discuss their research with CLEM experts and receive practical and troubleshooting advice. Audience This course is intended for scientists with experience in EM who want to further develop their skills in high-accuracy correlated microscopy. Modules/resources The course will...

20 February - 24 February 2023

Introduction to RNA-seq and functional interpretation

Sophie Spencer

Gain an introduction to the technology data analysis tools and resources used in RNA sequencing and transcriptomics The content will provide a broad overview of the subject area and introduce participants to basic analysis of transcriptomics data using the command line It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data Topics will be delivered using a mixture of lectures practical exercises and open discussions Computational work during the course will use small example data sets and there will be no opportunity to analyse personal data In person course We plan to deliver this course in person in our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing... Gain an introduction to the technology, data analysis, tools, and resources used in RNA sequencing and transcriptomics. The content will provide a broad overview of the subject area, and introduce participants to basic analysis of transcriptomics data using the command line. It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data. Topics will be delivered using a mixture of lectures, practical exercises, and open discussions. Computational work during the course will use small, example data-sets, and there will be no opportunity to analyse personal data. In-person course We plan to deliver this course in-person in our training suite at EMBL-EBI, Hinxton.  Please be aware that we are continually evaluating the ongoing pandemic situation and, as such, may need to change the format of courses at...

26 February - 3 March 2023

Analysis and integration of transcriptome and proteome data

Vladimir Benes, Raffaele Calogero, Jeroen Krijgsveld, Lennart Martens

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells tissues and organisms operate in their biological context Among the... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells, tissues and organisms operate in their biological context. Among the key technologies driving this forward are next-generation sequencing and proteomics, as they provide powerful means to determine global expression levels of genes and proteins. Both fields have matured to a degree that they have now become accessible to researchers in many areas of biology. During this course, participants will gain theoretical insight in the structure of sequencing and proteomic data, and they will receive training in data analysis for the annotation, quantification, and statistical...

5 March - 10 March 2023

Techniques for mammary gland research

Martin Jechlinger, Renée van Amerongen, María dM Vivanco

OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview The mammary epithelium is a unique organ in that the majority of its development occurs postnatally This combined with ease of experimental access and a stereotypical growth pattern make it... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview The mammary epithelium is a unique organ in that the majority of its development occurs postnatally. This, combined with ease of experimental access and a stereotypical growth pattern, make it an ideal tissue for studying cellular homeostasis, branching morphogenesis, hormonal effects, stem cell biology and breast cancer. This theoretical and practical course will present techniques for the dissection and dissociation of different subpopulations of both mouse and human mammary cells, including stem/progenitor cells. It will also include flow cytometry to separate single cell populations for the consequent in vitro (mammosphere and 3D cultures) and in vivo...

6 March - 10 March 2023

Introduction to multiomics data integration and visualisation

Shereen Pethania

With the increase in the volume of data across the whole spectrum of biology more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences This may also include public domain data which can provide added value to data derived through researcher s own work and inform experimental design This introductory course will highlight the challenges that researchers face in integrating multiomics data sets using biological examples The course will focus on the use of public data resources and open access tools for enabling integrated working with an emphasis on data visualisation This course will not include systems biology modelling or machine learning A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI data resource and research teams This allows people to explore the bioinformatics tools and resources introduced in the course and to apply these to a set problem providing hands on experience of relevance to their own research The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of integrating data You may refer to the previous group projects that were organised for this course in March 2022 Additional information The course fee is inclusive of four nights accommodation and catering including dinner We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Hybrid options are not currently available Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website... With the increase in the volume of data across the whole spectrum of biology, more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences. This may also include public domain data, which can provide added value to data derived through researcher’s own work and inform experimental design. This introductory course will highlight the challenges that researchers face in integrating multiomics data sets using biological examples. The course will focus on the use of public data resources and open access tools for enabling integrated working, with an emphasis on data visualisation. This course will not include systems biology modelling or machine learning. A major element of this course is a group project, where participants will be placed in small groups to work together on a challenge set by trainers from EMBL-EBI data...

8 March - 11 March 2023

The cellular mechanics of symbiosis

Toby Kiers, John McCutcheon, Thomas Richards

OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Symposium overview Host microbe interactions can be positive or negative for both a host organism and its... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Symposium overview Host-microbe interactions can be positive or negative for both a host organism and its symbiotic microbes. Interacting with microbes can allow eukaryotes to acquire crucial functions, like nutrient production, but interactions can also be pathogenic in nature. This cross-disciplinary meeting will bring together scientists using cellular, molecular, ecological, physiological, and theory-based approaches to explore the evolution of intimate species-species interactions. Our aim is to understand the cellular systems and pathways that drive transitions in symbiotic states, for example, as...

12 March - 17 March 2023

Extracellular vesicles: from biology to biomedical applications

An Hendrix, Cecilia Lässer, Esther Noltet Hoen, Guillaume Van Niel

A rapidly increasing number of researchers aim to purify and identify extracellular vesicles and many methodologies to isolate and analyse these vesicles are available and have been implemented This course will cover the basics possibilities and limitations of different purification and characterisation techniques and will address strategies to understand their role in biomedical applications... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview A rapidly increasing number of researchers aim to purify and identify extracellular vesicles and many methodologies to isolate and analyse these vesicles are available and have been implemented. This course will cover the basics, possibilities, and limitations of different purification and characterisation techniques and will address strategies to understand their role in biomedical applications. Audience This course is intended for PhD students and Postdoctoral researchers who are interested in learning how to work with extracellular vesicles and know more about their biomedical applications. Modules/resources Extracellular vesicles (continuous and discontinuous density gradient...

21 March - 30 March 2023

Exploring human genetic variation

Juanita Riveros

Do you want to learn more about genetic variation Are you aware of the resources available for finding viewing and exploring variant data Are you trying to link variant data to phenotypes This four day workshop will demonstrate resources and bioinformatics tools available at EMBL EBI and the Wellcome Sanger Institute that will aid understanding of human genetic variation During the first three days you will learn how to browse retrieve and use human genetic variation data via talks demos and tutorials You will then be provided with exercises to work through the resources on your own with remote trainer support available if needed and provided space to meet other participants if you wish to do so We will meet again on 30 March for a Q A session and discussion about any questions or issues that occurred while working on the materials provided Virtual course Participants will learn via a mix of live talks demos hands on exercises and trainer Q A sessions Practical experience will be developed through homework activities with remote trainer support Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Participants will need to be available between the hours of 09 30 15 30 GMT each day of the course from 21 23 March 2023 and from 09 30 12 00 BST on 30 March 2023 Trainers will be available to assist answer questions and provide further explanations during these times... Do you want to learn more about genetic variation? Are you aware of the resources available for finding, viewing, and exploring variant data? Are you trying to link variant data to phenotypes? This four-day workshop will demonstrate resources and bioinformatics tools available at EMBL-EBI and the Wellcome Sanger Institute that will aid understanding of human genetic variation.  During the first three days, you will learn how to browse, retrieve, and use human genetic variation data via talks, demos, and tutorials. You will then be provided with exercises to work through the resources on your own with remote trainer support available if needed and provided space to meet other participants if you wish to do so. We will meet again on 30 March for a Q&A session and discussion about any questions or issues that occurred while working on the materials provided. Virtual course...

26 March - 1 April 2023

Measuring translational dynamics by ribosome profiling

Pavel Baranov, Sebastian Leidel, Jan Medenbach, Elisabeth Zielonka

OverviewSpeakers trainers and staffPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview Regulation of translation is key in the control of gene expression playing a critical role in many biological and pathophysiological settings In the last... OverviewSpeakers, trainers, and staffPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview Regulation of translation is key in the control of gene expression, playing a critical role in many biological and pathophysiological settings. In the last decade, methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes, however, the systems-wide analysis of translation remained an unsolved experimental challenge. The advent of ‘ribosome-profiling’ provided the methodological basis for comprehensive transcriptome-wide analyses of translation at sub-codon resolution by the precise and high-throughput determination of ribosomal positions on mRNA. Its application in a variety of organisms yielded novel insights into...

28 March - 31 March 2023

Introduction to metabolomics analysis

Jane Reynolds

This course will provide an introduction to metabolomics through lectures and hands on sessions using publicly available data software and tools Participants will become familiar with the current state of experimental design data acquisition LC MS MS imaging processing and modelling In addition they will learn about community standards and sharing in metabolomics particularly through using the EMBL EBI s MetaboLights repository and Galaxy infrastructure Participants will learn through hands on tutorials to use tools available for data analysis and data submission Additionally case studies will be used to discuss and show how to employ the week s learning In person course We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Additional information The course fee is inclusive of three nights accommodation and catering including dinner Please note that we will operate this course face to face at EMBL EBI Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website... This course will provide an introduction to metabolomics through lectures and hands-on sessions, using publicly available data, software, and tools. Participants will become familiar with the current state of experimental design, data acquisition (LC-MS, MS imaging), processing, and modelling. In addition, they will learn about community standards and sharing in metabolomics, particularly through using the EMBL-EBI’s MetaboLights repository and Galaxy infrastructure. Participants will learn through hands-on tutorials to use tools available for data analysis and data submission. Additionally, case studies will be used to discuss and show how to employ the week’s learning. In-person course We plan to deliver this course in an in-person manner onsite at our training suite at EMBL-EBI, Hinxton.  Please be aware that we are continually evaluating the ongoing pandemic situation and, as...

28 March - 31 March 2023

VIZBI 2023: visualizing biological data

Barbora Kozlikova, Marc A. Marti-Renom, Andrea Schafferhans, Nico Scherf, Michelle Scott, Srigokul Upadhyayula

The conference will feature talks from 21 world leading researchers showcasing visualizations transforming how life scientists view data and driving key advances in molecular biology systems biology biomedical science and ecology... This conference will take place at EMBL Heidelberg, with the option to attend virtually. Proof of COVID-19 vaccination or recovery is required for on-site attendance. Please see EMBL’s COVID-19 safety policy for on-site events.  Registration is not yet open for this event. If you are interested in receiving more information please register your interest.  Conference overview Visualisation is increasingly important in life science as data grows rapidly in volume and complexity. The VIZBI initiative is an international conference series bringing together researchers developing and using computational visualisation to address a broad range of biological research areas; the conference also attracts participation from medical illustrators, graphic designers, and graphic artists. VIZBI is held annually, usually alternating between Europe and the USA. More information on...

17 April - 18 April 2023

EuroFAANG AQUA-FAANG workshop: methods to use and reuse the AQUA-FAANG data and Ensembl resources to advance science

Shereen Pethania

This one and a half day workshop will provide detailed training on methods to use and reuse the wealth of data generated by the EuroFAANG AQUA FAANG project AQUA FAANG aims to improve understanding the genome function and usage of genotype to phenotype prediction in the six most important European farmed fish species EUROPEAN SEABASS GILTHEAD SEABREAM RAINBOW TROUT ATLANTIC SALMON COMMON CARP TURBOT The workshop will primarily focus on the comprehensive and integrated annotation of these six species by the Ensembl genome browser The course will also include a deeper dive from the Ensembl analysis teams into gene annotation and regulation and demonstrations of the specific analyses and research conducted by AQUA FAANG scientists Additional information The course fee is inclusive of one night of accommodation and catering including dinner We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Hybrid options are not currently available Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website... This one and a half day workshop will provide detailed training on methods to use and reuse the wealth of data generated by the EuroFAANG AQUA-FAANG project. AQUA-FAANG aims to improve understanding the genome function and usage of genotype-to-phenotype prediction in the six most important European farmed fish species (EUROPEAN SEABASS | GILTHEAD SEABREAM | RAINBOW TROUT | ATLANTIC SALMON | COMMON CARP | TURBOT). The workshop will primarily focus on the comprehensive and integrated annotation of these six species by the Ensembl genome browser. The course will also include a deeper dive from the Ensembl analysis teams into gene annotation and regulation, and demonstrations of the specific analyses and research conducted by AQUA-FAANG scientists. Additional information The course fee is inclusive of one night of accommodation and catering, including dinner. We plan to deliver this course...

17 April - 24 April 2023

Microbial metagenomics: a 360º approach

Vladimir Benes, Giuseppe D´Auria, José Eduardo González-Pastor, Elisabeth Zielonka

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview The course focuses on the highly interdisciplinary topic of metagenomics During the course participants will receive an overview of state of the art genomic technologies and... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview The course focuses on the highly interdisciplinary topic of metagenomics. During the course, participants will receive an overview of state-of-the-art genomic technologies and bioinformatic tools. A balanced approach of lectures and practical sessions will provide a general background and the latest advancements in the field as well as its relationship with other disciplines. The course will start with training the participants about experimental design and the preparation of their own metagenomic libraries with soil or their (environmental) samples. The metagenomic DNA will be sequenced onsite using third generation sequencing technologies and subsequent data analysis. Thus, the...

25 April - 28 April 2023

Brain genome: regulation, evolution, and function

Roberto Bonasio, Matthieu Boulard, Magdalena Götz, Kyung-Min Noh

This symposium will explore how the brain genome is regulated in order to support neural function and neural plasticity... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Symposium overview This symposium explores the many ways by which the genome is regulated in the brain in order to support neural function and plasticity. The extraordinary complexity of the brain places unique demands on the genome: How are several hundreds of different neural types specified by the same genetic instructions? Does the genome provide information that guides their connectivity? How is neural activity regulated by and how does it affect genome output? We will explore these fundamental questions from the standpoint of transcriptional regulation and chromatin-based processes, including but not...

25 April - 27 April 2023

Bioinformatics resources for protein biology

Juanita Riveros

Are you aware of the wide range of protein data resources that can easily be accessed and explored to enhance your research Do you want to know more about the sequence of your protein and its functions Wondered whether a structure of your protein exists and how to explore it Want to know more about the potential complexes and reaction pathways your protein of interest is involved in giving you a better overview of its biological context This short virtual course will introduce you to data resources and tools developed by EMBL EBI that can help you in your protein studies During the first three days you will learn about how to browse retrieve and use EMBL EBI protein data in theory Those who are interested in learning more about programmatic access to EMBL EBI protein resources can attend an optional section on this topic on 25 April 2023 For an introduction to the concept of web services and how you can use them to access the tools and data available at EMBL EBI please watch our webinar You will then be provided exercises for each resource you will work through on your own in the following week with remote trainer support available if needed We will meet again on 4 May 2023 to discuss issues that occurred while working through the material in more detail Additional information Please note that we will operate this course virtually Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic Virtual course Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there may be a brief induction session Participants will need to be available between the hours of 09 45 16 30 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times... Are you aware of the wide range of protein data resources that can easily be accessed and explored to enhance your research? Do you want to know more about the sequence of your protein and its functions? Wondered whether a structure of your protein exists and how to explore it? Want to know more about the potential complexes and reaction pathways your protein of interest is involved in, giving you a better overview of its biological context? This short virtual course will introduce you to data resources and tools developed by EMBL-EBI that can help you in your protein studies. During the first three days you will learn about how to browse, retrieve, and use EMBL-EBI protein data in theory. Those who are interested in learning more about programmatic access to EMBL-EBI protein resources can attend an optional section on this topic on 25 April 2023. For an introduction to the concept of...

7 May - 12 May 2023

Advanced fluorescence imaging techniques

Aliaksandr Halavatyi, Stefan Marawske, Rainer Pepperkok, Stefan Terjung

This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms Invited guest researchers together with experts from the EMBL and microscopy professionals will foster an intense information flow with a balance of lectures and practical workshops The focus of the course will be on the use of fluorescence microscopy to obtain information about protein localisation dynamics and functions at different spatial scales... OverviewSpeakersPreliminary programmePractical informationSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms. Invited guest researchers together with experts from the EMBL and microscopy professionals will foster an intense information flow with a balance of lectures and practical workshops. The focus of the course will be on the use of fluorescence microscopy to obtain information about protein localisation, dynamics, and functions at different spatial scales. Audience...

8 May - 12 May 2023

Data visualisation for biology

Jane Reynolds

This course will give insights into and practical experience in data visualisation for exploring complex and multi dimensional biological data Biological and life sciences data often consists of multiple dimensions a combination of numerical values ordered data categories and time series To make sense of this data simple plots like scatterplots barcharts and boxplots are often not enough Still visualisation is critical in gaining deep insight into the data This is why many custom visualisations originated in the biological field In this course we will dive into the topic of visualisation of complex biological data and how it can be used to gain insight into and get a feel for a dataset so that targeted analyses can be defined It will be delivered through a mixture of lectures and workshop sessions and will provide hands on experience in developing visualisations The course will focus on working with omics e g genomics transcriptomics data rather than e g imaging data Additional information The course fee is inclusive of four nights accommodation and catering including dinner We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Hybrid options are not currently available Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Monday 8 May will be a bank holiday in the UK to mark the Coronation of King Charles III The course will take place as outlined in the programme including sessions as planned on Monday 8 May Should you be selected as a participant please take extra care planning your travel to the course as public transport may be affected by the Coronation Saturday 6 May and bank holiday Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website... This course will give insights into, and practical experience in, data visualisation for exploring complex and multi-dimensional biological data. Biological and life sciences data often consists of multiple dimensions: a combination of numerical values, ordered data, categories, and time-series. To make sense of this data, simple plots like scatterplots, barcharts, and boxplots are often not enough. Still, visualisation is critical in gaining deep insight into the data. This is why many custom visualisations originated in the biological field. In this course, we will dive into the topic of visualisation of complex biological data and how it can be used to gain insight into and get a "feel" for a dataset, so that targeted analyses can be defined. It will be delivered through a mixture of lectures and workshop sessions, and will provide hands-on experience in developing visualisations. The...

9 May - 12 May 2023

The organism and its environment

Detlev Arendt, Edith Heard, Maria Leptin, Fiona Watt, Detlef Weigel

OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview We are at the dawn of a new era of biology where we will start to understand how organisms function together and react or adapt to changes at different molecular levels. This includes the multitude of stresses that organisms are exposed to, from malnutrition and adverse climate events to many other biological, chemical and physical insults. Progress in biological analyses at both a single scale and across scales, have allowed us to further understand organisms...

15 May - 18 May 2023

Chromatin and epigenetics

Asifa Akhtar, Yehudit Bergman, Nicola Iovino, Gary Karpen, Sarah Teichmann

Epigenetics refers to heritable changes in gene expression that do not involve changes to the underlying DNA sequence At least three systems including DNA methylation histone modifications and non coding RNAs ncRNA are considered to play fundamental roles in epigenetic regulation Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases Moreover influence of age environment lifestyle and disease state on epigenetic states is being increasingly appreciated and actively studied This conference provides an international forum for cutting edge research in chromatin and epigenetics It provides the focal hub for people to present their research and exchange ideas in a virtual format Renowned speakers will cover the latest advances in the field... OverviewSpeakersPractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Conference overview Epigenetics refers to heritable changes in gene expression that do not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases. Moreover influence of age, environment, lifestyle, and disease state on epigenetic states is being increasingly appreciated and actively studied. This conference provides an international forum for cutting...

16 May - 18 May 2023

Practical biocuration

Sophie Spencer

This three day course will introduce concepts vital to biocuration including metadata and ontologies the role of identifiers and extracting data from literature During the course there will be a focus on practical skills required by biocurators including programming for handling large biological datasets and querying databases Participants will have the opportunity to use these skills in a real life practical biocuration exercise during the group projects There will also be an opportunity to network with biocurators and learn more about their roles and data resources Group projects A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI and external institutes This allows people to explore the role of biocurators and provide participants with hands on experience in biocuration The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion in the whole course group Groups are mentored and supported by the trainers who set the initial challenge but the groups will be responsible for driving their projects forward with all members expected to take an active role Groups are pre organised before the course Basic outlines of the projects on offer this year are given below In your registration you must indicate your first and second choice of project Not all projects may be offered and final decisions on which projects will be run during the course will be made based on the number of applicants per project Project one Curating a protein complex In this project a new protein complex has been published and it is your role to find out as much information as possible about the complex Using literature and bioinformatics resources you will provide an overview of the protein complex including a full list of the complex members a description of the role of each protein and an overview of the role of the complex You will use resources such as UniProt PDB and EuropePMC Project mentor Michelle Magrane Project two Exploring data and metadata from a genome wide association study The GWAS Catalog is a richly annotated database of human genome wide association studies which analyse associations between genetic variants and a disease or other trait of interest in a sample of individuals from a particular population In this mini project you will examine a GWAS publication in detail to extract information about the traits and samples under investigation and decide how to represent these metadata using standardised vocabularies and ontologies You will also use simple command line tools to look at a GWAS dataset and explore the role of standard formats and quality control in biocuration Project mentor Elliot Sollis Project three Curating a mathematical model of biological pathway In this project you will find a short mathematical model of your area of interest and try to encode and reproduce the simulation results using COPASI Using EuropePMC you will find a small ordinary differential model ODE mathematical model of a pathway You will encode the pathway using the software COPASI and reproduce the result of the published pathway There may also be an opportunity to submit a model to BioModels Project mentor Krishna Tiwari Project four Using alignments to improve Rfam families a case of curating non coding RNA families Rfam is the database of non coding RNAs ncRNAs families These families are built out of a sequence alignment metadata describing the family and an infernal model Each family is built by curating alignments from publications or user submitted alignments In this project we will demonstrate the process of updating an existing family with an improved alignment We will examine the reports generated during curation In this process we will examine the phylogenetic distribution sequence alignment and model results to determine how the family should be updated to reflect the improved alignment Additionally we will show how to connect this information to resources like Wikipedia Project mentor Nancy Ontiveros Project five Annotating an electron microscopy image dataset EMPIAR Electron Microscopy Public Image Archive is a free public resource for raw images underpinning 3D cryo EM maps and tomograms EMPIAR also accommodates 3D datasets obtained with volume EM techniques and soft and hard X ray tomography In this project you will use EMPIAR to annotate a selected electron microscopy image dataset Project mentor Simone Weyand... This three-day course will introduce concepts vital to biocuration, including metadata and ontologies, the role of identifiers, and extracting data from literature.  During the course, there will be a focus on practical skills required by biocurators, including programming for handling large biological datasets, and querying databases. Participants will have the opportunity to use these skills in a real-life practical biocuration exercise during the group projects.  There will also be an opportunity to network with biocurators and learn more about their roles and data resources. Group projects A major element of this course is a group project, where participants will be placed in small groups to work together on a challenge set by trainers from EMBL-EBI and external institutes. This allows people to explore the role of biocurators and provide participants with hands-on...

21 May - 26 May 2023

Whole transcriptome data analysis

Marco Beccuti, Vladimir Benes, Raffaele Calogero, Francesca Cordero

This course will teach the biological researchers how to analyse biological data sets using open source software Most of the analysis will be performed with docker4seq package which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis... OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Course overview This course will teach the biological researchers how to analyse biological data sets using open-source software. Most of the analysis will be performed with docker4seq and rCASC packages, which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis. Docker4seq and rCASC packages use docker containers that embed demanding computing tasks (e.g. short reads mapping) into isolated containers. This approach provides multiple advantages: the user does not need to install all the software on its local server, the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing...

22 May - 26 May 2023

Expansion microscopy

Niccolo Banterle, Gautam Dey, Paul Guichard, Virginie Hamel, Marine Laporte

OverviewSpeakers Trainers and StaffSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Expansion microscopy ExM physically magnifies specimens allowing to... OverviewSpeakers, Trainers and StaffSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Expansion microscopy (ExM) physically magnifies specimens, allowing to obtain super-resolution images using a conventional diffraction-limited microscope such as confocal microscopy. This powerful technique is easy to implement but it requires some hands-on training. This workshop aims at disseminating and discussing expansion microscopy protocols and is intended for cell biologists, parasitologists, etc, with applications ranging from tissue to cells. Audience This course is intended for researchers ranging from PhD students to post-docs and senior scientists who wish to...

22 May - 26 May 2023

Microscopy data analysis: machine learning and the BioImage Archive

Shereen Pethania

This virtual course will show how public bioimaging data resources centred around the BioImage Archive enable and enhance machine learning based image analysis The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi modal imaging data at the cell and tissue scale Participants will cover contemporary biological image analysis with an emphasis on machine learning methods as well as how to access and use images from databases Further instruction will be offered using applications such as ZeroCostDL4Mic ilastik ImJoy the BioImage Model Zoo and CellProfiler Virtual course This course will be a virtual event delivered via a mixture of live streamed sessions pre recorded lectures and tutorials with live support We will be using Zoom to run the live sessions all fully password protected with automated English closed captioning and transcription with support and both scientific and social networking opportunities provided by Slack and other methods taking different time zones into account In order to make the most out of the course you should make sure to have a stable internet connection throughout the week and are available between 08 00 18 00 BST each day In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Selected participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course... This virtual course will show how public bioimaging data resources, centred around the BioImage Archive, enable and enhance machine learning based image analysis. The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi-modal imaging data at the cell and tissue scale. Participants will cover contemporary biological image analysis with an emphasis on machine learning methods, as well as how to access and use images from databases. Further instruction will be offered using applications such as ZeroCostDL4Mic, ilastik, ImJoy, the BioImage Model Zoo, and CellProfiler. Virtual course This course will be a virtual event delivered via a mixture of live-streamed sessions, pre-recorded lectures, and tutorials with live support. We will be using Zoom to run the live sessions (all fully password protected with automated English closed...

23 May - 25 May 2023

BioMalPar XIX: biology and pathology of the malaria parasite

BioMalPar XVIII will showcase the multidisciplinary nature of malaria research with a programme that welcomes clinical malaria epidemiological studies immunology and evolution and ecology alongside core BioMalPar topics... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Travel grants and fee waivers are available for BioMalPar XIX. Please note that the deadline to apply for this financial assistance to attend onsite is 7 December 2022 (earlier than the general abstract deadline). Conference overview Malaria remains one of the most significant global public health challenges, with more than 200 million clinical cases worldwide each year. The lack of a vaccine that provides effective long-term protection and the continual emergence of drug-resistant malaria parasites emphasises the need for new control and prevention strategies. This need for innovation has become even more...

4 June - 7 June 2023

The ageing genome: from mechanisms to disease

Jacqueline Jacobs, Gaëlle Legube, Brian Luke, Björn Schumacher

OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Symposium overview Time stands still for no one or for no molecule for that matter Of the... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Symposium overview “Time stands still for no one” or for no molecule, for that matter. Of the molecules that undergo changes over time, it is chromosomal alterations that may have some of the most profound and long-lasting cellular and organismal effects. In contrast to any other macromolecule, the genome is irreplaceable and requires constant repair. Despite sophisticated genome maintenance mechanisms, DNA damage accumulates over time and hence with age. The ensuing chromosomal alterations may lead to genome instability, somatic mutations, impaired gene expression and DNA replication, alterations of the...

5 June - 9 June 2023

Deep learning for image analysis

Anna Kreshuk, Constanin Pape, Pejman Rasti, Daid Rousseau, Martn Weigert

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview The advent of deep learning has brought a revolution in the field of computer vision including most... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview The advent of deep learning has brought a revolution in the field of computer vision, including most tasks and research questions concerned with microscopy image analysis. Neural networks have been successfully used for image restoration, classification and segmentation, for the detection of objects and characterisation of their morphology, for high-throughput imaging and large-scale processing in 3D. Despite these advances, training and deployment of such neural networks remains difficult for practitioners of image analysis. The aim of our course is to close this gap and teach the participants – in the most...

11 June - 16 June 2023

Quantitative proteomics: strategies and tools to probe biology

Jeroen Krijgsveld, Christina Ludwig, Mikhail Savitski

OverviewSpeakersSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview This course will provide both theoretical and practical training in the use of quantitative... OverviewSpeakersSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview This course will provide both theoretical and practical training in the use of quantitative proteomics approaches.  Participants will learn the principles of current methodologies including label-free, SILAC and TMT as well as targeted proteomics, and they will be trained in the use of bioinformatic tools for data analysis.  Audience This course is aimed at researchers who know the basics of proteomics and who want to get a deeper understanding of quantitative methodologies, and at those who are familiar with wet-lab proteomic experimentation but want to gain experience in bioinformatic data...

12 June - 15 June 2023

Life at the periphery: mechanobiology of the cell surface

Alba Diz Muñoz, Zemer Gitai, KC Huang, Ewa Paluch

OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Symposium overview After a very engaging virtual first edition in 2021 this hybrid symposium on cell... OverviewSpeakersPreliminary programmePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Symposium overview After a very engaging virtual first edition in 2021, this hybrid symposium on cell surface mechanics will bring together researchers across kingdoms of life interested in dynamic processes occurring at the cell surface. The focus will be on new technologies that empower studies of cell wall, cytoskeleton, and membrane biology, such as advanced imaging in in vitro and in vivo systems, as well as approaches combining molecular biology with computational and biophysical approaches. The first edition started building a much-needed bridge between the wall and wall-less...

12 June - 16 June 2023

Summer school in bioinformatics

Sophie Spencer

This course provides an introduction to the use of bioinformatics in biological research giving participants guidance for using bioinformatics in their work whilst also providing hands on training in tools and resources appropriate to their research Participants will initially be introduced to bioinformatics theory and practice including best practices for undertaking bioinformatics analysis data management and reproducibility To enable specific exploration of resources in their particular field of interest participants will be divided into focused groups to work on a project set by resource and data experts from EMBL EBI and external collaborating institutes These projects will end with a presentation from each group on the final day of the course to bring together learnings from all participants Group projects A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI and external institutes This allows people to explore the bioinformatics tools and resources available in their area of interest and apply them to a set problem providing participants with hands on experience relevant to their own research The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of working with biological data Groups are mentored and supported by the trainers who set the initial challenge but the groups will be responsible for driving their projects forward with all members expected to take an active role Groups are pre organised before the course and all group members will be sent some short homework in preparation for their project work prior to the start of the course Basic outlines of the projects on offer this year will be listed soon In your application you must indicate your first and second choice of project based on which you think would benefit your research most Not all projects may be offered and final decisions on which projects will be run during the course will be made based on the number of applicants per project Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course provides an introduction to the use of bioinformatics in biological research, giving participants guidance for using bioinformatics in their work whilst also providing hands-on training in tools and resources appropriate to their research. Participants will initially be introduced to bioinformatics theory and practice, including best practices for undertaking bioinformatics analysis, data management, and reproducibility. To enable specific exploration of resources in their particular field of interest, participants will be divided into focused groups to work on a project set by resource and data experts from EMBL-EBI and external collaborating institutes. These projects will end with a presentation from each group on the final day of the course to bring together learnings from all participants. Group projects A major element of this course is a group project, where...

18 June - 23 June 2023

Computational modelling of multicellular systems

Katie Bentley, James Sharpe, Alejandro Torres-Sánchez

Proof of COVID 19 vaccination or recovery is required to attend this on site course Please see EMBL s COVID 19 safety policy for on site events Registration is not yet open for this event If you are interested in receiving more information please register your interest... Proof of COVID-19 vaccination or recovery is required to attend this on-site course. Please see EMBL’s COVID-19 safety policy for on-site events.  Registration is not yet open for this event. If you are interested in receiving more information please register your interest.

19 June - 21 June 2023

Managing a bioinformatics core facility

EMBL-EBI Training

This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL EBI s service teams from each other and from potential users of their services These facilities play an essential role in enabling research in the molecular life sciences The landscape is constantly evolving as new research tools emerge experiments become increasingly data intensive and their clients experimental researchers become more exposed to the power of data driven biology Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL-EBI’s service teams, from each other, and from potential users of their services. These facilities play an essential role in enabling research in the molecular life sciences. The landscape is constantly evolving as new research tools emerge, experiments become increasingly data-intensive, and their clients – experimental researchers – become more exposed to the power of data-driven biology. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course face-to-face at EMBL-EBI in Hinxton. Hybrid options are not currently available. We reserve the right to change the format of...

19 June - 20 June 2023

Terra incognita: navigating ethical boundaries in the life sciences

Lucia von Bredow

Overview Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest What past participants say about the conference... Overview Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. What past participants say about the conference “The excellent EMBL Science & Society conferences are a terrific opportunity for scientists at all career stages, and from anywhere in the world, to join wide-ranging debates on the practical, ethical and social implications of today’s research.” – Chris Dye, University of Oxford, UK “The conference was awesome. I enjoyed the interesting topics covered by experts from reputable institutions from all top universities in the world. I felt like I physically attended the...

19 June - 21 June 2023

Bioinformatics for principal investigators

Jane Reynolds

This course has been designed to provide principal investigators PI s working in the life sciences with an introduction to the challenges of working with biological data as a research leader Starting with a look at where bioinformatics and data science fits into their research teams the course will enable PI s to take a strategic look at the requirements for undertaking such work and how bioinformatics capacity can be developed from personnel through to computational needs It will additionally provide guidance on strategies for managing data the importance of data sharing how to work with computational collaborators and what resources are available across the life sciences to support such work During this course we will not be teaching hands on bioinformatics analysis but we will be signposting appropriate training resources to upskill you and your team In person course We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course has been designed to provide principal investigators (PI's) working in the life sciences with an introduction to the challenges of working with biological data as a research leader. Starting with a look at where bioinformatics and data science fits into their research teams, the course will enable PI’s to take a strategic look at the requirements for undertaking such work and how bioinformatics capacity can be developed from personnel through to computational needs. It will additionally provide guidance on strategies for managing data, the importance of data sharing; how to work with computational collaborators and what resources are available across the life sciences to support such work. During this course, we will not be teaching hands-on bioinformatics analysis, but we will be signposting appropriate training resources to upskill you and your team. In-person course We...

25 June - 30 June 2023

Imaging-based spatial-omics

Alvaro Crevenna, Emerald Perlas, Sinem Saka

OverviewSpeakersPreliminary programmePractical informationSponsors Overview Course overview The aim of the course is to provide participants a comprehensive introduction to the various methods of spatial omics and in particular those of multiplex immunofluorescence and spatial transcriptomics We want to provide a general overview of the methods and assist researchers choose the right... OverviewSpeakersPreliminary programmePractical informationSponsors Overview Course overview The aim of the course is to provide participants a comprehensive introduction to the various methods of spatial-omics and in particular those of multiplex immunofluorescence and spatial transcriptomics. We want to provide a general overview of the methods and assist researchers choose the right method for their needs. With hands-on practicals, the course will teach participants how to carry out open-source imaging-based methods for cost-effective spatial transcriptomics and multiplex immunofluorescence. The course will cover all experimental stages, including custom reagent preparation, sample preparation and data acquisition (with various microscopy modalities) as well as image processing and data analysis. Audience This course is open to PhD students, postdocs and staff. We seek participants...

25 June - 30 June 2023

PerMedCoE summer school: from pathway modelling tools to cell-level simulations

Juanita Riveros

The course will combine lectures and hands on exercises to Introduce attendees to key practicalities of working with high performance computing HPC clusters Build first hand experience in using PerMedCoE modelling tools CellNOpt CARNIVAL COBREXA MaBoSS PhysiCell and PhysiBoSS Develop a practical appreciation of using workflow managers and containerised PerMedCoE modelling tools to execute biomedical workflows It will also include poster sessions where participants can present their work and plenty of time for interaction between participants and between participants and trainers This course will take place in Spain More details to be announced... The course will combine lectures and hands-on exercises to…  Introduce attendees to key practicalities of working with high-performance computing (HPC) clusters Build first-hand experience in using PerMedCoE modelling tools (CellNOpt, CARNIVAL, COBREXA, MaBoSS, PhysiCell and PhysiBoSS) Develop a practical appreciation of using workflow managers and containerised PerMedCoE modelling tools to execute biomedical workflows It will also include poster sessions where participants can present their work and plenty of time for interaction between participants and between participants and trainers. This course will take place in Spain. More details to be announced.

27 June - 30 June 2023

New approaches and concepts in microbiology

Pascale Cossart, Sophie Helaine, KC Huang, Michael Laub, Nassos Typas

This symposium will cover a broad range of topics in microbiology including antibiotic related research bacterial communities and microbiome cell biology regulation signalling pathogenesis and evolution Emphasis will be placed on novel approaches and technologies from systems based to single cell that drive each field or have the potential to revolutionise future research in microbiology... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Symposium overview This symposium will cover a broad range of topics in microbiology, featuring diverse research on bacterial physiology, bacterial communities and microbiomes, bacterial–host and –phage interactions, and bacteria in their natural ecological contexts. Emphasis will be placed on novel approaches and technologies (from systems-based to single-cell) that drive each field or have the potential to revolutionise future research in microbiology. This meeting is the sixth of its kind, part of a successful series which started in 2013 and held biannually since, becoming a must-attend event for...

3 July - 7 July 2023

Proteomics bioinformatics

Shereen Pethania

This course provides hands on training in the basics of mass spectrometry MS and proteomics bioinformatics post processing software quantitative approaches search engines and MS data repositories public databases for protein analysis annotation and incorporation of information from molecular interaction and pathway databases Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course provides hands-on training in the basics of mass spectrometry (MS) and proteomics bioinformatics, post-processing software, quantitative approaches, search engines and MS data repositories, public databases for protein analysis, annotation, and incorporation of information from molecular interaction and pathway databases. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course face-to-face at EMBL-EBI in Hinxton. Hybrid options are not currently available. We reserve the right to change the format of this course or cancel it, due to the ongoing coronavirus pandemic.

10 July - 14 July 2023

Fluorescence imaging beyond intensity

Marko Lampe, Rainer Pepperkok, Ulf Schwarz

OverviewSpeakersSponsorsPractical information Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest This course is organised in cooperation with Leica Microsystems Course overview As... OverviewSpeakersSponsorsPractical information Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. This course is organised in cooperation with Leica Microsystems. Course overview As fluorescence lifetime-based readouts become more accessible, this course aims to provide a broad understanding of how the lifetime-based information can be leveraged to solve biological questions. This application-centred course will provide insights into how this additional dimension of fluorescence information can help unveil functional and mechanistic information. Audience This course is aimed at PhD students and Post Docs with experience in fluorescence microscopy. It will enable them to better apply confocal...

10 July - 14 July 2023

Cancer genomics

Sophie Spencer

This course will focus on the analysis of data from genomic studies of cancer Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers This course is aimed at PhD students and post doctoral researchers who are applying or planning to apply high throughput sequencing technologies in cancer research and wish to familiarise themselves with bioinformatics tools and data analysis methodologies specific to cancer data Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course will focus on the analysis of data from genomic studies of cancer. Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data, whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers. This course is aimed at PhD students and post-doctoral researchers who are applying or planning to apply high throughput sequencing technologies in cancer research and wish to familiarise themselves with bioinformatics tools and data analysis methodologies specific to cancer data. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course...

11 July - 14 July 2023

Predicting evolution

Justin Crocker, Gautam Dey, Joshua Payne, Patricia Wittkopp

The conference will explore the evolution of biological systems at different levels from genes and molecules to organism development and ecology... OverviewSpeakersPractical informationSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview Advances in genome sequencing and gene editing tools are providing unprecedented insights into biological mechanisms and evolutionary processes. In parallel, computational and theoretical approaches are providing new insights into our understanding of these new data. A goal for this conference is to unite people across theoretical and experimental backgrounds into a coherent focus on “predicting evolution”. The conference will explore the evolution of biological systems at different levels: from...

16 July - 21 July 2023

Drosophila genetics and genomics

Justin Crocker, Kate O'Connor-Giles, Ella Preger-Ben Noon, Andreas Prokop

The course combines interactive theoretical discussions that have been successfully used to train generations of Drosophila researchers for nearly 30 years combined with cutting edge experimental approaches taught by experts in the field... OverviewSpeakersPreliminary programmePractical informationSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview The fruit fly Drosophila has played a leading role in the discovery and dissection of basic biological processes, uncovering general principles of development, evolution and disease. Almost a century of research has generated a powerful genetic toolbox that provides a unique arsenal of methods that can tackle almost any biological question. This, combined with exciting new technologies developed in recent years have changed the way Drosophila research is conducted, enabling biologists to address questions that were impossible to study before.  The course has...

18 July - 21 July 2023

Theory and concepts in biology

Alexander Aulehla, Jordi Garcia-Ojalvo, Robert Phillips. Kirsty Wan

OverviewSpeakersPreliminary programmePractical informationSponsorsAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your... OverviewSpeakersPreliminary programmePractical informationSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview Recent progress in biology has led to an explosion of factual knowledge about the living world over a huge range of scales in space and time. Yet, many questions about how to make sense of this data remain across the entire diversity of the living world from the smallest bacterium to the ecosystems of the Serengeti. This meeting aims to bring together a diverse collection of researchers interested in finding ways to parlay this ever-increasing factual knowledge into a...

24 July - 4 August 2023

Plasticity in developing systems: time, space, and environment

Alexander Aulehla, Alexandra Reversi

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course Overview The course will allow participants to gain advanced conceptual knowledge in modern developmental biology... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course Overview The course will allow participants to gain advanced conceptual knowledge in modern developmental biology, emphasizing developmental plasticity across the tree of life. External leading scientists and Developmental Biology EMBL group leaders will provide a two-week-long programme of lectures, practicals and discussion groups, covering different topics related to how environmental factors influence development, physiology, and behaviours. The course will use hands-on lab experience to introduce participants to the great diversity of developmental modes in a wide range of species, including bacteria, algae, plants, sea...

6 September - 10 September 2023

Protein synthesis and translational control

Matthias Hentze

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Conference overview Mechanisms that shape cellular proteomes are critical for life This conference focuses on... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Conference overview Mechanisms that shape cellular proteomes are critical for life. This conference focuses on the process of protein synthesis, from the molecular and structural understanding of the translational machinery to its regulation, its implications in cell and organismal biology, and its alteration in disease. The regulation of mRNA translation is critical to maintain cell homeostasis and mediates cellular responses to environmental, physiological, and pathological cues. Given the central importance of protein synthesis, it is unsurprising that dysregulation or defects in mRNA translation are widely...

10 September - 15 September 2023

Advanced methods in bioimage analysis

Ignacio Arganda-Carreras, Anna Klemm, Perrine Paul-Gilloteaux, Christian Tischer

OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Bioimage analysis has become a keystone of... OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Bioimage analysis has become a keystone of biological research: the deluge of data produced by increasingly advanced microscopes calls for experts able to guide life scientists in the methods and software to be used to produce quantitative knowledge from this data. Due to the complexity of the data, without such expert guidance, it is very likely that image analysis algorithms may be applied incorrectly, possibly even producing erroneous results. Moreover, the diversity of imaging modalities, analysis algorithms and software solutions is growing so rapidly...

12 September - 15 September 2023

Developmental metabolism: flows of energy, matter, and information

Alexander Aulehla, Heidi Lempradl, Jonathan Rodenfels

OverviewSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Overview The fundamental question of... OverviewSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Overview The fundamental question of the role of metabolism in development has seen a revival in interest. This is fueled by recent work, shedding new light onto previously unrecognized roles of metabolism. This work revealed the intricate relationship between energy flux, spatial and temporal control of metabolites, the environment and embryogenesis. This emerging view is stimulating research designed to answer fundamental questions including: How does the cellular machinery process information linked to the flow of energy and matter? How...

17 September - 22 September 2023

Genome engineering: CRISPR/Cas from cells to mice

Neil Humphreys, Birgit Koch, Elisabeth Zielonka

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other events, or contact sponsorship@embl.de for further information. If you are interested in becoming a media partner of this event, please visit our media partnerships webpage. Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes...

18 September - 22 September 2023

Single-cell RNA-seq analysis using Python

EMBL-EBI Training

This course covers the analysis of scRNA seq data Participants will be guided through droplet based scRNA seq analysis pipelines from raw reads to cell clusters They will explore and interpret data using Python and the Single Cell Expression Atlas Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course virtually Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course covers the analysis of scRNA-seq data. Participants will be guided through droplet-based scRNA-seq analysis pipelines from raw reads to cell clusters. They will explore and interpret data using Python and the Single Cell Expression Atlas. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course virtually. Hybrid options are not currently available. We reserve the right to change the format of this course or cancel it, due to the ongoing coronavirus pandemic.

20 September - 23 September 2023

The human microbiome

Manimozhiyan Arumugam, Ami Bhatt, Peer Bork, Nicola Segata

Human microbiota the collection of microbes living in and on our body have a significant impact on human health and well being They have been associated with numerous diseases yet we have barely understood their role in the context of life style and genetics Various initiatives are underway around the world to survey the human microbiota at several body sites characterise them understand their interactions with the human hosts elucidate their role in diseases and design possible therapeutic or dietary interventions There is a new wave of studies mining the human microbiota for bioactive compounds such as antibiotics and for characterising specific microbial strains This conference will provide plentiful opportunities for researchers to learn about and to connect to important developments in studying the human microbiota... OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview Human microbiota – the collection of microbes living in and on our body – have a significant impact on human health and well-being. They have been associated with numerous diseases, yet we are still far from understanding their role in the context of lifestyle and genetics. Various initiatives are underway around the world to survey the human microbiota at several body sites, characterise them, understand their interactions with the human hosts, elucidate their role in diseases, and design possible therapeutic or...

2 October - 6 October 2023

Structural bioinformatics

EMBL-EBI Training

This course explores bioinformatics data resources and tools for the investigation analysis and interpretation of both experimentally determined and predicted biomacromolecular structures It will focus on how best to analyse and interpret available structural data to gain useful information given specific research contexts The course content will also cover predicting function and exploring interactions with other macromolecules Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course explores bioinformatics data resources and tools for the investigation, analysis, and interpretation of both experimentally determined and predicted biomacromolecular structures. It will focus on how best to analyse and interpret available structural data to gain useful information given specific research contexts. The course content will also cover predicting function, and exploring interactions with other macromolecules. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course face-to-face at EMBL-EBI in Hinxton. Hybrid options are not currently available. We reserve the right to change the format of this course or cancel it, due to the ongoing coronavirus pandemic.

4 October - 7 October 2023

Seeing is believing: imaging the molecular processes of life

Jan Ellenberg, Jennifer Lippincott-Schwartz, Satyajit Mayor, Atsushi Miyawaki

The symposium will bring together the leading developers of imaging methods with cutting edge applications that illustrate how imaging can answer biological questions We will emphasize methods that can capture the dynamics of life spanning the whole range from molecular resolution to imaging of whole organisms From its beginning in 2011 Seeing is Believing has embraced novel imaging technologies that open new windows for biological discovery including single molecule and super resolution light sheet and correlative light electron microscopy... OverviewSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level. The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes, organelles, cells, tissues, organs and whole organisms. Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease.The symposium will bring together the leading...

9 October - 14 October 2023

Liquid biopsies

Anders Ståhlberg, Karin Sundfeldt

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course Overview Liquid biopsies have the advantage of being largely non invasive and providing a vast amount of information... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course Overview Liquid biopsies have the advantage of being largely non-invasive and providing a vast amount of information for the detection and monitoring of diseases such as cancer. This course will provide an overview in the several techniques to detect and analyse circulating tumour cells (CTCs), cell free tumor DNA (ctDNA), miRNA in liquid biopsies, cell free tumour RNA (ctRNA) and proteins. Participants will be introduced to all aspects ranging from proper sampling through error free sequencing to data analysis. Additional lectures will cover extracellular vesicles and clinical aspects using liquid biopsies, especially in...

11 October - 14 October 2023

The non-coding genome

Marc Bühler, Anna Eulálio, Joshua Mendell, Gisela Storz, Igor Ulitsky

This symposium will explore the diverse dynamic and multifaceted roles of RNA across a spectrum of cellular processes It will provide an interdisciplinary discussion of the roles of non coding RNAs in both prokaryotes and eukaryotes with the aim of enhancing our understanding of gene regulation and function... OverviewSpeakersPractical informationSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview Over the past two decades, advances in transcriptomic methods have led to the discovery of a very rich and diverse set of RNA transcripts, short and long, that serve as regulators rather than templates for protein production. Many of these transcribed elements are encoded in noncoding regions of the genome with other regulatory and structural DNA elements of known and unknown functions. While the catalogs of such elements are very rich, and an ever-increasing number are implicated in almost...

18 October - 21 October 2023

Organoids: modelling organ development and disease in 3D culture

Meritxell Huch, Karl R. Koehler, Madeline Lancaster, Esther Schnapp

OverviewSpeakersPractical informatonSponsorsAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Symposium overview The ability to grow human tissues from stem cells in 3D culture has the potential to revolutionise the drug discovery... OverviewSpeakersPractical informatonSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Symposium overview The ability to grow human tissues from stem cells in 3D culture has the potential to revolutionise the drug discovery process and regenerative medicine. Building on a long tradition of cell and developmental biology knowledge, organoids resembling a variety of human tissues have been generated. This conference will bring together the leading researchers in this field to establish a new research community and reveal parallels between various tissue models. The aim of this meeting is to bring together researchers from different fields to enhance our understanding of how organoids can be formed and maintained, how they...

22 October - 27 October 2023

FISHing for RNAs: classical to single molecule approaches

Monica Ballarino, Imre Gaspar, Emerald Perlas, Elisabeth Zielonka

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Over the past decades it became evident that a RNA transcripts specific amount and localisation are... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Over the past decades it became evident that a RNA transcripts specific amount and localisation are important in order to understand the biological function of its (non-) coding gene. Whereby state-of-the-art in situ hybridisation (ISH) technologies are key to visualise these RNAs in a given tissue or cell. This course aims to highlight three powerful RNA visualisation techniques in histological tissue samples. During this course, the participants will learn to validate the cellular localisation of candidate genes from transcriptome studies through conventional ISH and, the more recent cutting-edge, smFISH (Single...

23 October - 27 October 2023

Systems biology: from large datasets to biological insight

Jane Reynolds

This course covers the use of computational tools to extract biological insight from omics datasets The content will explore a range of approaches ranging from network inference and data integration to machine learning and logic modelling that can be used to extract biological insights from varied data types Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large scale biological data The motivation for running this course is a result of advances in computer science and high performance computing that have led to groundbreaking developments in systems biology model inference With the comparable increase of publicly available large scale biological data the challenge now lies in interpreting them in a biologically valuable manner Likewise machine learning approaches are making a significant impact in our analysis of large omics datasets and the extraction of useful biological knowledge Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course covers the use of computational tools to extract biological insight from omics datasets. The content will explore a range of approaches - ranging from network inference and data integration to machine learning and logic modelling - that can be used to extract biological insights from varied data types. Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large-scale biological data. The motivation for running this course is a result of advances in computer science and high-performance computing that have led to groundbreaking developments in systems biology model inference. With the comparable increase of publicly-available, large-scale biological data, the challenge now lies in interpreting them in a biologically valuable manner. Likewise, machine learning approaches are...

25 October - 27 October 2023

Proteomics in cell biology and disease mechanisms

Yu-Ju Chen, Ileana Cristea, Albert Heck, Matthias Mann

OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview The 6th Pr... OverviewSpeakersSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview The 6th Proteomics in Cell Biology and Disease Mechanisms conference will again be held in association with EMBL-EBI and the Wellcome Genome Campus. The field of proteomics continues to develop rapidly due to technological and computational advances in high-throughput methods and multi-omics big data integration. This year’s programme will focus on medical and clinical applications of proteomics, particularly in cell biology and infectious diseases. The conference will also highlight technological...

30 October - 3 November 2023

Metagenomics bioinformatics

EMBL-EBI Training

Learn about the tools processes and analysis approaches used in the field of genome resolved metagenomics This course will cover the use of publicly available resources to manage share analyse and interpret metagenomics data focussing primarily on assembly based approaches Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... Learn about the tools, processes and analysis approaches used in the field of genome-resolved metagenomics. This course will cover the use of publicly available resources to manage, share, analyse and interpret metagenomics data, focussing primarily on assembly-based approaches. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course face-to-face at EMBL-EBI in Hinxton. Hybrid options are not currently available. We reserve the right to change the format of this course or cancel it, due to the ongoing coronavirus pandemic.

6 November - 10 November 2023

Solution scattering from biological macromolecules

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest This course consists of two parts virtual and onsite The virtual course takes place 6 10 November 2023 and the onsite part takes... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. This course consists of two parts: virtual and onsite. The virtual course takes place 6 – 10 November 2023 and the onsite part takes place 27 November – 1 December 2023. Course overview The virtual course will cover the basics of SAXS/SANS, instrumentation, data collection, modelling techniques and complementary use with other methods. The students are encouraged to sign-up for a self-paced practical tutorial that covers basic and advanced SAXS data processing steps (including quizzes to keep track of successful participation). In addition, students are encouraged to apply to the ‘add on module’ which includes an on-site...

6 November - 10 November 2023

Preparation of genomic libraries for an emerging next-gen sequencing platform

Vladimir Benes, Bjorn Textor

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other events, or contact sponsorship@embl.de for further information. If you are interested in becoming a media partner of this event, please visit our media partnerships webpage. Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes...

8 November - 11 November 2023

The mobile genome: genetic and physiological impacts of transposable elements

Déborah Bourc’his, Julius Brennecke, Jose L. Garcia-Perez, Susan Wessler

This conference is assembling world leading experts from diverse fields including genomics epigenetics structural biology developmental biology immunology cancer biology and neurobiology to discuss the broad impacts of TEs on organismal biology... OverviewSpeakersPreliminary programmePractical informationSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Conference overview This conference assembles world-leading experts from diverse fields including genomics, epigenetics, structural biology, developmental biology, immunology, cancer biology, and neurobiology to discuss the broad impacts of TEs on organismal biology. The meeting provides a venue for cross-disciplinary discussions, with the goal of catalysing inter-disciplinary collaborations to address emerging questions in these scientific fields. Although often disparaged as “junk” DNA, it is now undeniable that transposable element (TE) activity has significantly shaped the structure and function of all genomes,...

13 November - 17 November 2023

Hands-on flow cytometry: learning by doing!

Andrew Filby, Diana Ordonez, Malte Paulsen, Steffen Schmitt

Flow Cytometry is one of the most powerful single cell analysis methods used throughout the life sciences and medicine By utilising Flow Cytometry we can identify and quantify specific cell populations from heterogeneous samples analyse the cell cycle or proliferation state or simply detect the expression of fluorescent reporters In line with the suggestions from our course in 2019 we will significantly enhance the number of analysis sessions together with our partners from FlowJo We will cover the theory of Flow Cytometry and corroborate this information intensively with the practical issues of the most frequent assays as part of our practical course curriculum... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Flow Cytometry is one of the most powerful single cell analysis methods used throughout the life sciences and medicine. By utilising Flow Cytometry we can identify and quantify specific cell populations from heterogeneous samples, analyse the cell cycle or proliferation state or simply detect the expression of fluorescent reporters. In line with the suggestions from our course in 2019, we will significantly enhance the number of analysis sessions together with our partners from FlowJo. We will cover the theory of Flow Cytometry and corroborate this information intensively with the practical issues of the most...

15 November - 17 November 2023

Cancer genomics

Isidro Cortes Ciriano, Christina Curtis, Nuria Lopez-Bigas, Young Seok Ju

OverviewSpeakersPractical InformationSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference... OverviewSpeakersPractical InformationSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview This meeting will provide an opportunity to learn about and keep up to date with the rapidly progressing area of cancer genomics. We aim to bring together scientists from across several disciplines connected with cancer research, for a unique opportunity to interact and stimulate further integration of these efforts. Session topics Mutation & clonal selection in normal tissuesGenomic instability & mutational processesCancer evolutionCancer ecosystems & micro-environmentEmerging...

20 November - 22 November 2023

25th EMBL PhD Symposium

2023 EMBL PhD Symposium Organising Committee

Join us for the 25th Anniversary of the annual EMBL PhD Symposium Since its conception in 1999 the EMBL PhD Symposium has evolved into a highly respected scientific meeting connecting young researchers and high profile scientists alike...

20 November - 24 November 2023

Genome bioinformatics: resequencing and variant calling

EMBL-EBI Training

This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data The main focus will be on introducing sequence informatics re sequencing and variant calling during the analysis of higher eukaryotes with an emphasis on human genetic research Throughout the week more advanced topics will introduce the creation of pipelines automation and the scaling up of analysis experiments Additional information To receive alerts and updates on this course please click the Register Interest button on the right hand side This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic... This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data. The main focus will be on introducing sequence informatics, re-sequencing, and variant calling during the analysis of higher eukaryotes, with an emphasis on human genetic research. Throughout the week, more advanced topics will introduce the creation of pipelines, automation, and the scaling-up of analysis experiments. Additional information To receive alerts and updates on this course, please click the 'Register Interest' button on the right-hand side. This course is currently under construction and so details are subject to change. Please note that we will operate this course face-to-face at EMBL-EBI in Hinxton. Hybrid options are not currently available. We reserve the right to change the format of this course or...

28 November - 1 December 2023

Subcortical sensory circuits: visual, auditory, somatosensory, and beyond

Hiroki Asari, Santiago Rompani

OverviewSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview Subcortical... OverviewSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview Subcortical sensory circuits a fundamental role in the perception of the outside world. However, their function has previously been underestimated as simple effectors of behavioral reflexes or relay stations that passively transmit sensory information to the cortex. Recent studies, however, suggest that subcortical pathways also perform sophisticated computations, such as integrating peripheral information among many sensory pathways and the animal’s internal states. This meeting will gather leading researchers in the...

4 December - 8 December 2023

Fundamentals of widefield and confocal microscopy and imaging

Heiko Gaethje, Aliaksandr Halavatyi, Stefan Marawske, Jens Marquardt

OverviewSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Light microscopy is the most widely used form of microscopy for life science research The correct handling... OverviewSponsors Overview Please see EMBL’s COVID-19 safety policy for testing and other requirements to attend this on-site course. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Course overview Light microscopy is the most widely used form of microscopy for life science research. The correct handling of the microscope and optimising image quality (e.g. contrast, resolution) as well as experimental design according to different applications are crucial to obtain the best results. This course will provide the participants with an overview about the basics of microscopy (light and optics, contrast techniques and imaging). The confocal part will include multicolor, 3D and time lapse imaging as well as spectral imaging, photobleaching (FRAP, FLIP, FLAP) and photoactivation techniques. Basic image analysis tools...

6 December - 9 December 2023

Computational structural biology

Jan Kosinski, Rommie Omaro, Christine Orengo, Samir Velankar

OverviewSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview The field of... OverviewSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview The field of computational structural biology is undergoing a revolution. AlphaFold, a program based on Artificial Intelligence (AI), has transformed the structural modeling of proteins and protein complexes by reaching accuracy similar to experimental structures. Over 200 million structural models have already been released in AlphaFold Database. Following AlphaFold, other protein modeling programs proliferated from researchers worldwide. AI has started advancing RNA modeling too. The wealth of protein models has sparked...

20 February - 23 February 2024

The new cardiobiology

Pilar Alcaide, Johannes Backs, Tina Haase, Enzo Porrello

OverviewSponsors Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview The cardiovascular... OverviewSponsors Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Conference overview The cardiovascular system is a multicellular and disseminated organ consisting of the heart, a network of vessels and circulating blood, thereby forming an intricately interdependent system, whose dysfunction is the leading cause of human mortality. Despite translational progress with impactful new interventional and pharmacological therapies, cardiovascular dysfunction continues to plague mankind. The current therapeutic approaches are either organ-centric or tackle the consequences of end-stage...

9 April - 12 April 2024

Diversity of plants: from genomes to metabolism

Barbara Ann Halkier, Sarah E. O’Connor, Detlef Weigel

OverviewSponsorsAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Registration is not yet open for this event If you are interested in receiving more information please register your interest Symposium overview This inaugural... OverviewSponsorsAbout Overview This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event. Registration is not yet open for this event. If you are interested in receiving more information please register your interest. Symposium overview This inaugural EMBO | EMBL Symposium aims to showcase the future of plant biology. Going beyond the limited number of model plants that plant biologists have historically focused on (e.g. Arabidopsis, corn, rice), it is nowadays possible to use comparative approaches to uncover the mechanistic basis and the evolutionary drive for the enormous phenotypic variation among the 400,000 species of plants on Earth. Europe has a large and thriving community of plant biologists, with particular expertise in plant diversity at...