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The tuatara, an iguana-like reptile with a crest of spikes, sits on a forest floor.

The curious genome of the tuatara, an ancient reptile in peril

A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.

By Mehdi Khadraoui

Science

A woman with glasses holds a book. The book cover says "Gene naming rules". Thought bubbles float around her head and display gene symbols like BRCA1.

Bagpipe and Pokemon, or how not to name a human gene

The human genome harbours about 19 000 protein-coding genes, many of which still have no known function. As scientists unveil the secrets of our DNA, they come across novel genes that they need to refer to using a unique name. The Human Genome Organisation’s Gene Nomenclature Committee (HGNC) at…

By Mehdi Khadraoui

Science

This visual representation shows the newly identified architecture (left) of the coupled molecular machines responsible for transcription (green; DNA in magenta) and translation (blue and yellow), accompanied by the protein interaction network from mass spectrometry (centre) and the cryo-electron tomography data (right) from Mycoplasma pneumoniae that was used to model the structure. Credit: Liang Xue and Julia Mahamid/EMBL

Visualising the cell’s molecular machinery in action

A new approach that allows researchers to see molecular machinery at work inside cells has offered a deeper understanding of how bacteria produce proteins and a unique glimpse into how they respond to antibiotics.

By Ivy Kupec

Science

Europe PMC logo with red viral particles floating around it. Credit: Spencer Phillips/EMBL, iStock

Europe PMC: unlocking the potential of COVID-19 preprints

Europe PMC has begun indexing full-text COVID-19 preprints along with the associated data. The project aims to accelerate research to fight the SARS-CoV-2 virus.

By Mehdi Khadraoui

Science

Atomic model of the entire condensin complex

Understanding chromosome organisation

EMBL scientists and collaborators help reveal the process by which enormous quantities of DNA are folded into cells.

By Edward Prior

Science

Mosaic of microscopy images of tumour, forming two broken DNA molecules

Artificial intelligence finds patterns of mutations and survival in tumour images

Researchers have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients. The algorithm can distinguish between healthy and cancerous tissues, and can also identify patterns DNA and RNA changes in tumours.

By Mehdi Khadraoui

Science

Top row: The evolution of tumour cells (green) within a normal organoid (grey) shown in three panels. Lower row: Surface rendition of tumour cells and labels new cells that arise from a single cell in the same colour.

A tool to improve cancer research

EMBL scientists have created a new, realistic 3D testbed that could help achieve the goal of stopping cancers before they start by studying cancer cells as they first form.

By Ivy Kupec

Science

A magnifying glass hovers over the human gut, revealing its biodiversity.

Unparalleled inventory of the human gut ecosystem

An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health.

By Mehdi Khadraoui

Science

stem cells neurons differentiation

From stem cells to neurons

Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…

By Fabian Oswald

Science

epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

By Rossana De Lorenzi

Science

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