Celebrating Stephen Cusack’s contributions to science
Events Researchers from across the globe have gathered in Grenoble to celebrate the remarkable lifelong scientific achievements of Stephen Cusack, the former head of EMBL Grenoble.
2023
events
Switching off the cytokine storm
Science EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.
2023
science
Revealing the secrets of protein evolution using the AlphaFold database
Research highlights, Science Researchers use the AlphaFold database and Foldseek Cluster algorithm to analyse millions of predicted protein structures and offer new insights into protein evolution.
2023
research-highlightsscience
Swordfish sword under X-rays: SAXS explained
Science Learn how scientists use bio-SAXS, an experimental X-ray technique, to study the shape and dynamics of proteins and other biomolecules. SAXS can be even used to analyse the structure of mineral particles in the swordfish sword bone, which can help scientists better understand bone ageing.
2023
science
Welcome: Clément Blanchet
Lab Matters Clément Blanchet has been appointed to lead the team working on small-angle X-ray scattering (SAXS) at EMBL Hamburg. In this interview, he talks his ambitions for the future work of the SAXS Team, his passion for science, and a memorable ‘aha’ moment he had in his early career.
2023
lab-matters
A glimpse into the hexasome: 40 years on
Science Research from the Eustermann group at EMBL Heidelberg reveals how the packaging of DNA into hexasomes impacts the function of enzymes involved in gene regulation.
2023
science
We are EMBL: Rutuja Yelmar on her life as a PhD student at EMBL Grenoble
Lab Matters Rutuja Yelmar, predoctoral Fellow at EMBL Grenoble in the Kowalinski group, talks about her passion for research, daily inspiration, and the importance of collaboration in achieving her goals.
2023
lab-matters
Spotlight: Shedding light on deadly parasites
Lab Matters, Picture of the week This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.
2023
lab-matterspicture-of-the-week
Facilitating drug discovery against COVID-19
Science A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.
2023
science
Bringing research on disordered proteins to order
Science, Technology and innovation A third of all known proteins are either completely or partially unstructured. EMBL scientists contributed to a new set of guidelines – Minimum Information About a Disorder Experiment (MIADE) – that will help researchers share data on unstructured proteins in a more useful way and will enable…
2023
sciencetechnology-and-innovation
Janet Thornton retires: a pioneer in structural bioinformatics
Announcements, Lab Matters In recognition of Janet Thornton’s retirement, we look back at some of her biggest accomplishments shaping the field of bioinformatics.
2023
announcementslab-matters
We are EMBL: Martin Pelosse on his role at the Eukaryotic Expression Facility
Lab Matters Martin Pelosse, Scientific Expert at EMBL Grenoble Eukaryotic Expression Facility, explains the platform’s role in supporting the site’s cutting-edge research activities and its future applications.
2023
lab-matters
Behind the scenes of innovation
EMBLetc EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.
2023
Time-resolved crystallography for the masses
Science EMBL Hamburg scientists have contributed to the development of the Spitrobot, a ground-breaking experimental setup that will simplify creating molecular movies. The Spitrobot automates the sample preparation for time-resolved crystallography, which is used to create 3D snapshots of protein…
2023
science
We are EMBL: Eduard Avetisyan on the role of IT in structural biology
Lab Matters Eduard Avetisyan leads the EMBL Hamburg IT team. He joined EMBL after transitioning from particle physics research to IT. Besides providing standard IT user support, his team also enables smooth processing and computational analysis of structural biology data. Here, he talks about the joys and…
2023
lab-matters
We are EMBL: Audrey Spielmann on providing lab support
Lab Matters Audrey Spielmann, Lab Support Manager, talks about her role in supporting the research done at EMBL Grenoble.
2023
lab-matters
Welcome: Gergely Papp
Lab Matters Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.
2023
lab-matters
EMBL Grenoble showcased at Biophysical Society Meeting
Lab Matters EMBL’s French site was highlighted in a short film presenting its expertise in structural biology research and services.
2023
lab-matters
Biology meets engineering
Lab Matters Physicists, engineers and robotics experts work together in EMBL Hamburg’s Instrumentation Team to design instruments that support structural biology research. The team has finished a transfer robot that facilitates automated handling of protein crystals with care and precision. This will help…
2023
lab-matters
New EU-funded Project: Fragment-Screen
Lab Matters EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
2023
lab-matters
Supporting scientists across Europe: the SPC Facility at EMBL Hamburg
Lab Matters EMBL Hamburg’s Sample Preparation and Characterisation (SPC) Facility offers scientists access to almost all available biophysics technologies. The facility’s staff provides advice and support with experiments and data analysis. The facility is conveniently located just next to the EMBL…
2023
lab-matters
Case study: AlphaFold uses open data and AI to discover the 3D protein universe
Perspectives, Science Open data played a pivotal role in the development of the AlphaFold AI. The same open principles now apply to AlphaFold predictions.
2023
perspectivesscience
Solving the structure of a critical molecular editor
Science EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
2023
science
New molecular insights on medical cannabis
Science EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.
2023
science
Celebrating science in Grenoble
Lab Matters In October 2022, EMBL Grenoble participated in the annual science outreach event Parvis des Sciences, organised by the GIANT campus under the umbrella of the French science week – La Fête de la science.
2022
lab-matters
Getting closer to stopping toxoplasmosis infection
Science Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.
2022
science
Molecular solar panels can help scientists control brain cells
EMBLetc Kirill Kovalev, an EMBL Hamburg researcher, is studying the structure of an ancient bacterial molecule to help scientists control brain cell activity
2022
AlphaFold applications – a community assessment
Research highlights, Science Researchers use social media to share findings on how useful AlphaFold predictions are for different applications.
2022
research-highlightsscience
Two in one: combining MASSIF-1 and CrystalDirect
Lab Matters Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.
2022
lab-matters
Compare experimental and predicted structures with PDBe-KB
Updates from data resources You can now superpose AlphaFold models onto PDB structures at the touch of a button using the PDBe-KB aggregated views of proteins.
2022
updates-from-data-resources
Teaming up to drive forward time-resolved crystallography
Lab Matters The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities
2022
lab-matters
Seeing antibiotics in action inside a pathogenic bacterium
Science New research by EMBL scientists shows at atomic detail how antibiotics affect the process of protein production inside bacteria.
2022
science
PETRA IV and future opportunities at EMBL Hamburg beamlines
Lab Matters EMBL joined a kick-off event focusing on the developments related to the upgrade of the PETRA III synchrotron storage ring to PETRA IV at the DESY campus, where EMBL Hamburg is located. PETRA IV could open new possibilities at EMBL Hamburg, contributing to the goals of the EMBL Programme…
2022
lab-matters
AlphaFold: where will the next AI breakthrough come from?
Perspectives, Science Ewan Birney, Deputy Director General of EMBL and Director of EMBL-EBI, reveals the key factors that enabled AlphaFold to change the world of biology.
2022
perspectivesscience
Puzzling out the structure of a molecular giant
Science Scientists have solved several mysteries around the structure and function of a true molecular giant: the human nuclear pore complex. They created the most complete model of the complex thanks to combining the program AlphaFold2 with cryo-electron tomography, integrative modelling, molecular…
2022
science
Enabling imaging across scales
Events EMBL’s first Imaging Centre Symposium will occur onsite at EMBL and include tours of the new Imaging Centre on 31 May, introducing participants to the facility and its staff and featuring talks on the rapid developments in imaging technologies that have led to notable biological and medical…
2022
events
Next Head of EMBL Grenoble appointed
Lab Matters Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…
2022
lab-matters
Meet the next Head of EMBL Grenoble
Lab Matters Slovenian structural biologist Kristina Djinović-Carugo will join EMBL in July as the new Head of EMBL Grenoble. We spoke to her about her background, research interests, and plans for EMBL Grenoble.
2022
lab-matters
Learning from Deep Learning: the inspirational story behind AlphaFold
Science DeepMind visits EMBL Heidelberg to discuss current and future implications of Artificial Intelligence for life science research.
2022
science
Decoding the secrets of snake venom
Science EMBL Hamburg’s Grzegorz Chojnowski from the Wilmanns Group developed software called findMySequence, which identifies proteins’ amino-acid sequences based on electron cryo-microscopy and X-ray crystallography data. It’s useful for identifying unknown proteins in samples from natural sources.
2022
science
AlphaFold update – neglected tropical diseases
Updates from data resources Latest AlphaFold database update adds 27 new organisms and almost 200,000 new protein structure predictions relevant to neglected tropical diseases and antimicrobial resistance
2022
updates-from-data-resources
Capturing ‘snapshots’ of a crucial step in RNA splicing
Science The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
2022
science
EMBL-IAB collaboration on the rise
Lab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.
2021
lab-matters
Observing the secret life of molecules inside the cell
Science EMBL Hamburg’s Kosinski Group, the Beck Laboratory at the Max Planck Institute of Biophysics, and colleagues at EMBL Heidelberg recorded the nuclear pore complex contracting in living cells. They visualised the movement with an unprecedented level of detail with help of new software called…
2021
science
Solving molecular puzzles to find the perfect fit
Science Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.
2021
science
Artificial intelligence — a scientific game changer in 2021
Science The systematic application of AI in life sciences as in the AlphaFold algorithm for predicting protein structures has been named '2021 Breakthrough of the Year' by Science magazine.
2021
science
A gallery of human RNA polymerases
Science New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.
2021
science
How structural biology helps to make RNA vaccines
Science RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines, and how structural biology contributes to its development. EMBL Hamburg collaborated on several…
2021
science
Wrangling an octopus-like viral replication machine
Science EMBL structural biology is part of an international collaboration addressing zoonotic disease caused by Lassa virus.
2021
science
Welcome: Niccolò Banterle
Lab Matters Using gene editing and three types of microscopy, one of EMBL’s newest group leaders is deciphering the functions of one of the smallest molecules involved in cell division, motility, and signalling, known as a centriole.
2021
lab-matters
EMBL Hamburg trains future generations of life scientists in using SAXS
Lab Matters Each year, EMBL Hamburg’s Svergun Group offers practical EMBO courses and lecture courses on biological small-angle X-ray scattering (SAXS). The courses provide young scientists an opportunity to gain hands-on experience by measuring their own samples, and by exploring different aspects of SAXS…
2021
lab-matters
Ken Holmes
Alumni Ken Holmes, outstanding pioneer of structural biology and founder of EMBL´s Hamburg site, died on 2 November 2021 at the age of 87.
2021
alumni
Structure of a promiscuous protein will help scientists design better drugs
Science Scientists at EMBL Hamburg determined the molecular structure of Peptide Transporters 1 and 2. The findings will enable developing drugs that more efficiently pass from the gut to target tissues.
2021
science
How herpes seizes proteins’ means of production
Science The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…
2021
science
From creating new antimicrobials to combating Alzheimer’s disease
Science Structural biology provides insights into the diverse functions of fibrous protein in humans, amphibians, and bacteria.
2021
science
Cryo-Electron Microscopy Service Platform supports research on protein transport
Lab Matters Giulia Zanetti from the Institute of Structural and Molecular Biology (ISMB) in London explains how the collaboration with the Cryo-Electron Microscopy Service Platform enabled her group to reveal the structure of protein transport complexes.
2021
lab-matters
MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery
Lab Matters MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.
2021
lab-matters
Studying coronavirus proteins using small-angle X-ray scattering at European XFEL
Science A collaboration led by EMBL Hamburg’s Svergun Group used small-angle X-ray scattering (SAXS) at the European XFEL to obtain data on samples containing coronavirus spike proteins and antibodies that bind them.
2021
science
EMBL Alumni Awards 2021
Alumni EMBL alumni Ilaria Piazza and Ken Holmes have been recognised for their outstanding contributions, and will receive their awards as part of the celebrations for EMBL World Alumni Day.
2021
alumni
A model of cooperation for transporting mRNA
Science EMBL scientists generate a high-resolution crystal structure of the Kinesin-1/aTm1 transport complex in the fruit fly.
2021
science
From antibodies to nanoplastics
Science EMBL’s Melissa Graewert and colleagues are taking a structural biologist’s approach to better understanding nanoplastic particles.
2021
science
Structural biology reveals new opportunities to combat tuberculosis
Science EMBL Hamburg’s Wilmanns and Kosinski groups have determined the detailed structure of a bacterial protein complex critical for tuberculosis infection.
2021
science
EMBL scientists support malaria research
Science EMBL scientists support research on malaria by providing freely available data resources and using innovative experimental approaches. Our Course and Conference Office facilitates the exchange of knowledge in the field by hosting the annual BioMalPar conference.
2021
science
Reshaping the cell membrane with molecular pegs
Science Researchers at EMBL Hamburg reveal how peg-like proteins clasp and reshape the cell membrane
2021
science
Shaping the future of structural biology and X-ray imaging at EMBL Hamburg
Events A workshop run by EMBL Hamburg explored opportunities for structural biology at the future, upgraded PETRA IV synchrotron.
2021
events
EMBL provides key infrastructure for COVID-19 drug screening project
Science EMBL Hamburg’s integrated structural biology facility has contributed to the success of a large-scale SARS-CoV-2 study
2021
science
Variations on a spike
Picture of the week What does coronavirus’s spike protein look like in 3D? EMBL scientists and colleagues used cryo-electron tomography and molecular dynamics simulations to find out.
2021
picture-of-the-week
Structural biology at EMBL: driving technology development
Lab Matters Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.
2021
lab-matters
EMBL Hamburg lights the way to folding next-level origami
Science Using EMBL Hamburg’s world-class structural biology infrastructure, researchers advance the folding of protein ‘origami’ designed in the lab.
2021
science
New perspectives for treating psychiatric disorders
Science Scientists have determined the structure of Glycine Transporter 1. The finding could open new avenues for developing therapeutics for psychiatric disorders
2021
science
Droplet beauty
Picture of the week Scientists at EMBL Hamburg use droplets of protein solution to grow protein crystals. By exposing the crystals to X-rays, they are able to determine the protein’s molecular structure.
2021
picture-of-the-week
Touch of springtime in Grenoble
Picture of the week This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.
2021
picture-of-the-week
Purity, beauty, and perfection
Picture of the week The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.
2021
picture-of-the-week
At the core of the Integrator complex
Science A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
2021
science
Toadlet peptide transforms into a deadly weapon against bacteria
Science Researchers at the Technion – Israel Institute of Technology and EMBL Hamburg, in collaboration with scientists in Israel and Spain, have discovered remarkable molecular properties of an antimicrobial peptide from the skin of the Australian toadlet. The discovery could inspire the development of…
2021
science
Homage to a vital tool
Picture of the week Structural biologists want to study proteins at the atomic level. The device shown in this Picture of the Week is essential for this.
2021
picture-of-the-week
Discover the wonderful world of proteins: first virtual PDB Art exhibition
Lab Matters Schoolchildren create exquisite protein-inspired artworks
2020
lab-matters
First powder over EMBL Grenoble
Picture of the week The first snowflakes have fallen on the Vercors Mountains, right behind the EMBL Grenoble building, and an almost full moon is showing up during a sunny morning.
2020
picture-of-the-week
Seeing deeper inside cells
Science While cryo-electron tomography (cryo-ET) was first envisioned in 1968, the advances the Mahamid group are bringing to this 3D method for studying molecules directly inside cells are new, and are likely to greatly expand its use.
2020
science
Solving the protein structure puzzle
Science How artificial intelligence can help us solve the mysteries of the protein universe
2020
science
EMBL facilities support development of RNA vaccines
Science Biotechnology company BioNTech and Johannes Gutenberg University Mainz conduct collaborative research with EMBL scientists at the beamline P12 in Hamburg
2020
science
Scientists identify synthetic mini-antibody to combat COVID-19
Science By screening hundreds of sybodies (synthetic mini-antibodies), scientists have identified one that might stop SARS-CoV-2 from infecting human cells. This work, which holds promise for treating COVID-19, was conducted by EMBL Hamburg and collaborators from the Centre for Structural Systems Biology…
2020
science
Welcome: Meytal Landau
Lab Matters New associate group leader at EMBL Hamburg investigates the structure of functional amyloids in bacteria and in human disease
2020
lab-matters
How deadly parasites ‘glide’ into human cells
Science A group of scientists led by EMBL Hamburg’s Christian Löw provide insights into the molecular structure of proteins involved in the gliding movements through which the parasites causing malaria and toxoplasmosis invade human cells.
2020
science
Nuclear pores in their natural context
Science Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.
2020
science
Visualising the cell’s molecular machinery in action
Science A new approach that allows researchers to see molecular machinery at work inside cells has offered a deeper understanding of how bacteria produce proteins and a unique glimpse into how they respond to antibiotics.
2020
science
EMBL releases online course on solution scattering from biological macromolecules
Events The Svergun group at EMBL Hamburg has released the course ‘Solution Scattering from Biological Macromolecules’ in an online format for the first time. The course explores different aspects of small-angle X-ray scattering (SAXS) for studying the structure of macromolecules.
2020
events
Investigating the structure and mechanisms of coronavirus biomolecules
Science While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
2020
science
Genetic cut and paste at atomic resolution
Science Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
2020
science
Facilitating COVID-19 structural biology research
Science EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…
2020
science
EMBL SPC facility supports COVID-19 projects
Science The Sample Preparation and Characterisation Facility (SPC) at EMBL Hamburg reopens to support scientists working on Covid-19 research. The SPC Facility is one of the best equipped facilities in Europe is therefore in high demand from external users. Re-opening the facility also allows experts at…
2020
science
Responding to health threats posed by coronaviruses
Science By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.
2020
science
Remote access to EMBL structural biology pipelines to support research on SARS-CoV-2
Science The Marquez Team has restarted operations at the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble. The team has developed a fully automated protein-to-structure pipeline, which can be operated remotely and provides virtual access to the facilities.
2020
science
Supporting international research on the structure of the coronavirus
Science EMBL Heidelberg reopens the Cryo-Electron Microscopy Service Platform to support coronavirus structural biology research.
2020
science
How chromosome structure influences development
Science EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo
2020
science
Meytal Landau: a visiting researcher in Hamburg
Science Strengthening ties between EMBL and Israel through the Scientific Visitor Programme
2020
science
Empowering European structural biology
Lab Matters EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology
2019
lab-matters
Strengthening European biology
Lab Matters EMBL is now a member of the Instruct-ERIC organisation
2019
lab-matters
Understanding a key player in melanoma
Science A new paper describes a unique mechanism of partner selectivity in transcription factors.
2019
science
Photo-micropatterning advances structural cell biology
Science A new technique in cryo-EM
2019
science
New perspectives on nuclear pores
Science EMBL researchers have published two new studies involving the nuclear pore complex
2019
science
EMBL and Tara: Marseille
Events From 27–30 September, Tara will be docked in the port of Marseille, France’s second largest city.
2019
events
A tRNA modifier at work
Science Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.
2019
science
EMBL and Tara: Hamburg
Events EMBL Hamburg and Tara raise awareness of the risks of microplastic pollution and global infection
2019
events
Comprehensive protein data for drug development
Lab Matters PDBe-KB - new data resource for protein structure and function launches
2019
lab-matters
Welcome: Sagar Bhogaraju
Science New group leader at EMBL Grenoble is investigating the cellular role of melanoma antigens
2019
science
2019 alumni awards
Alumni Scientists honoured for contributions in cancer immunotherapy and structural biology
2019
alumni
Structure of prodrug-transporter complex revealed
Science Scientists develop structural model that could help in the development of drugs with increased absorption rates
2019
science
Most popular articles of the year: 2018
Lab Matters A collection of the most read articles from the EMBL news website in 2018
2019
lab-matters
Translating blue-sky research into the clinic
Lab Matters What does it take to create a vaccine or improve cancer therapies?
2018
lab-matters
New insights into the regulation of haemostasis
Science EMBL scientists investigate the structure of a key protein involved in blood clotting
2018
science
Time-resolved X-ray crystallography simplified
Science Speeding up time-resolved X-ray crystallography with EMBL beamline P14
2018
science
ARP/wARP 8.0 released
Lab Matters Researchers at EMBL Hamburg have released the next generation of their ARP/wARP software
2018
lab-matters
Guiding young scientists
Events 17 young scientists experienced hands-on training at EMBL Hamburg.
2018
events
Cohesin: a glue for DNA
Science EMBL scientists discover how a component of the cohesin ring binds DNA
2018
science
Humans of EMBL: Outreach
Lab Matters Discover how EMBLers across all sites share their passion for science
2018
lab-matters
Art meets structural biology
Science The Protein Data Bank in Europe celebrates its schools art project with its largest exhibition yet
2018
science
Algal nuclear pore complex revealed
Science EMBL scientists reveal NPC architecture of algae
2018
science
Welcome: Maria Garcia Alai
Science The new head of facility at EMBL Hamburg will help users solve protein puzzles
2018
science
Axon guidance and bundling are linked
Science EMBL scientists discover how two guidance cues work together when neurons project axons across the midline
2018
science
New cryo-EM service at EMBL Heidelberg
Science Access to state-of-the-art microscopes and outstanding expertise
2018
science
Life and death of proteins
Science EMBL scientists create a turnover catalogue of almost 10.000 proteins from primary cells
2018
science
Beamline ID23-2 tools up for ESRF upgrade
Lab Matters EMBL instrumentation teams adapting tech to run biological experiments on the synchrotron after its upgrade
2018
lab-matters
Pol III enzyme grips DNA and begins reading fast
Science EMBL researchers uncover how a key enzyme that helps cells make new proteins starts its work
2018
science
One way crossing across the midline
Science EMBL researchers solve a decades-long debate on a key process for brain and embryo-development
2018
science
Loops in DNA affect which proteins are coded
Science EMBL scientists unveil how 3D chromatin structure affects RNA splicing
2017
science
Futures: Unravelling influenza
Science ERC grantee Stephen Cusack shares his vision for the next ten years
2017
science
Alasdair McDowall’s slow road to flash freezing
Alumni How a research technician with a master’s degree contributed to Nobel Prize-winning work
2017
alumni
Enzymes’ superimposable structures revealed
Science EMBL scientists superimpose structures of two-metal-ion enzymes and reveal new potential drug targets
2017
science
Welcome: Eva Kowalinski
Science New group leader based in Grenoble aims to unveil the mechanisms of RNA editing
2017
science
Welcome: Julia Mahamid
Science The Mahamid group studies meso-scale molecular assemblies in intact cells and model organisms at molecular resolution
2017
science
Hands-on science inspires Hamburg
Events 20,000 visitors get sneak peek at giant particle accelerators at DESY DAY in Hamburg
2017
events
High-res Ebola model could spark new questions
Science EMBL researchers create highest resolution 3D model of important structure within Ebola virus
2017
science
CSSB: A new approach to infectious disease
Science Inside the Centre for Structural Systems Biology
2017
science
Research highlights
Science A summary of recent research highlights from EMBL
2017
science
EMBL and ESRF renew collaboration agreement
Lab Matters EMBL and the European synchrotron ESRF extend their Joint Structural Biology Group
2017
lab-matters
Supercool structures: new cryo-EM facility
Science As a new cryo-EM facility is inaugurated, EMBL’s Michael Hons describes his role in the project
2017
science
Fighting disease with structural biology
Alumni Alumnus Michael Parker talks about his career, research highlights and how EMBL has played a role
2017
alumni
Jacques Dubochet awarded Nobel Prize for chemistry
Science EMBL alumnus recognised for cryo-electron microscopy work
2017
science
Welcome: Jan Kosinski
Science EMBL’s new group leader based in Hamburg aims to create models of infection cycles
2017
science
The future is bright as XFEL opens its doors
Science Newly opened European X-Ray Free-Electron Laser celebrates start of user operations
2017
science
Bridging excellence: EMBL and Stanford’s Alliance
Events Lars Steinmetz. Director of the Life Science Alliance, reflects on the EMBL|Stanford initiative
2017
events
Solving the nucleosome: twenty years on
Events Tim Richmond looks back on the work that revealed the high-resolution structure of the nucleosome
2017
events
Futures: Phosphatases
Science ERC grantee Maja Köhn shares her vision for the next ten years
2017
science
Structure of key system for TB infection
Science EMBL scientists add crucial knowledge to understanding of the bacterium that causes tuberculosis
2017
science
Futures: The dark proteome
Science ERC grantee Edward Lemke shares his vision for the next ten years
2017
science
Cell division offers hope to fight antibiotic resistance
Science Keeping bacterial chromosomes tangled could lead to new approaches to treatment
2017
science
SESAME: a light in the desert
Alumni EMBL alumna Zehra Sayers key driver of the Middle East’s first synchrotron project
2017
alumni
Welcome: Wojciech Galej
Science New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression
2017
science
How flu steals your RNA
Science Understanding how the flu virus steals host RNA offers hope of new drugs
2016
science
Happy anniversary, PDBe!
Lab Matters Ewan Birney's nine "Structures of Christmas" celebrate 20 years of PDBe
2016
lab-matters
Structure of HIV capsid within virus visualised
Science EMBL scientists use new techniques to describe the architecture of conical HIV capsids
2016
science
10th PEPC course in Hamburg
Events The PEPC course celebrated its 10th anniversary in Hamburg from the 12 – 20 September this year
2016
events
Catching the chaperone in the act
Science How Christian Löw’s failed experiment led to an unexpected scientific journey
2016
science
Toxoplasma’s balancing act explained
Science Parasite’s method of rewiring our immune response leads to novel tool for drug tests
2016
science
New insights into RNA Polymerase I
Science Cryo EM reconstruction of RNA Polymerase I reveals details of how molecule binds and transcribes DNA
2016
science
Big data, cool servers
Lab Matters Upgraded server room is ready to take the heat at EMBL Grenoble
2016
lab-matters
Watching nuclear pores in growing nuclei
Science Puzzle of nuclear pore formation in growing nuclei solved
2016
science
New drug candidate unleashed for TB
Science EMBL researchers help to design a lead compound active against four different pathogens
2016
science
Opinion: 2006, a year of champagne
Lab Matters Stephen Cusack looks back on the early days of his collaboration with Anacor developing anti-infectives
2016
lab-matters
Opinion: A journey from bench to clinical trials
Lab Matters Andrés Palencia on the design of compounds that may help fight drug-resistant TB and more
2016
lab-matters
Taking crystallography to the fourth dimension
Science Collaborating to take crystallography into a new time dimension
2016
science
See data in a new light
Science 3D printing, gaming, virtual reality and lenticular posters bring new perspectives to research
2016
science
Atomic proportions
Science EMBL and ESRF scientists and mechanics work together on upgrade for one of Europe’s big X-ray sources
2016
science
Form follows function
Science 'The PDB plays a crucial role in structural biology research and development'
2016
science
Blocking the waste disposal unit
Science Detailed structure paves the way for more effective cancer therapies
2016
science
How new HIV drugs lock virus in immaturity
Science Study provides insights into workings of new HIV drugs and how virus becomes resistant
2016
science
Bork lab peers gather
Alumni 27 former Bork lab members joined Peer for a full-day get-together this summer
2016
alumni
Found in translation
Science Studying at EMBL in Grenoble helps Japanese postdoc see her native country through different eyes
2016
science
How cells bag their rubbish
Science How cells eliminate protein deposits that can lead to neurodegenerative disorders
2016
science
Leading the way in time-resolved crystallography
Science Establishing a programme of research, development and user services for time-resolved crystallography
2016
science
Partnership for Structural Biology: strength in diversity
Lab Matters Grenoble-based Partnership for Structural Biology (PSB) renewed for five more years
2016
lab-matters
Enzyme with a dual-purpose loop
Science Unexpected results: structure of DAPK enzyme reveals dual-purpose loop
2016
science
The man behind the machine
Science Florent Cipriani talks about his passion for developing beamline instrumentation
2016
science
Slovakian synergies
Alumni Meet a driving force behind collaborations with the Slovak Republic, alumnus Jozef Ševčik
2016
alumni
Crystals in the beamlight
Science CrystalDirect, developed at EMBL, automates crystal preparation for X-ray analysis
2016
science
Revealing structure of nuclear pore’s inner ring
Science First detailed structural description of all the rings of nuclear pores
2016
science
Designing gene therapy
Science Information on structure of molecule used for genome engineering yields increased efficiency
2016
science
Better tools for exploring TB protein structures
Science How an EMBL team is making and sharing tools to explore tuberculosis protein structures
2016
science
A cohesive structure
Science Structural insights into how cohesin keeps DNA together during the cell cycle
2016
science
True Love
Science How transcription factors interact to create a heart
2016
science
The cellular crystal factory
Science Hamburg collaborators analyse protein crystals inside the cells that made them.
2016
science
One gene, two proteins, one complex
Science Further insights into how viral enzymes degrade the cell walls of Clostridia bacteria.
2016
science
Periodic table of protein complexes
Science Making it easier to visualise, understand and predict how proteins combine to drive biological processes.
2015
science
Pol III: Completing the family album
Science CryoEM solves 3D atomic structure of largest and most elusive RNA polymerase.
2015
science
Awards & Honours
Lab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.
2015
lab-matters
High-throughput event
Events Energy, enthusiasm and endurance on tap as thousands attend 12-hour Hamburg Night of Science.
2015
events
Allergy: the price of immunity?
Science Findings help demonstrate the evolutionary basis for allergy.
2015
science
A whole new ball game
Lab Matters Hamburg researchers have a ball creating game to explain transporter protein mechanism.
2015
lab-matters
Checkpoint architecture
Science A nuclear pore riddle: how can you use the same number of pieces to form two rings that fit inside each other?
2015
science
MASSIFly efficient
Science MASSIF-1 processes its 10,000th crystal, less than one year after the beamline became operational.
2015
science
From side-project to valuable resource
Lab Matters Introducing the Small Angle Scattering Biological Data Bank, developed at EMBL Hamburg.
2015
lab-matters
Welcome: Janosch Hennig
Lab Matters “A structure alone is not so interesting, you need the biology too,” says new NMR-focused group leader
2015
lab-matters
Molecular momentum
Alumni Andrew Miller, first head of EMBL Grenoble, reflects on four decades at the Outstation.
2015
alumni
Awards & Honours
Lab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.
2015
lab-matters
EMBL Grenoble: Alumni stories
Alumni Alumni Reuben Leberman, Jeremy Smith, Elena Seiradake, and Winfried Weissenhorn share their stories.
2015
alumni
Welcome: Theodore Alexandrov
Science A mathematician who got ‘sucked in’ to biological problems, meet new team leader Theodore Alexandrov.
2015
science
Oskar’s structure revealed
Science 3D structure of Oskar protein gives first molecular insight into how it functions.
2015
science
Cell machinery wears complex coat
Science 3D imaging unravels COPI coat of cells' transport vesicles.
2015
science
Building bridges with BioStruct-X
Events Industrial partners and BioStruct-X facility members gather for Workshop at EMBL Hamburg.
2015
events
The curious case of the bi-specific enzyme
Science A puzzling peculiarity resolved by Hamburg’s Sample Preparation and Characterisation facility.
2015
science
From mountains to molecules
Events Staff, alumni, partners and more meet at EMBL Grenoble to celebrate Outstation's 40th anniversary.
2015
events
Oceans endeavour charts 40 million genes
Science Tara Oceans results reveal climate change insights, and a treasure trove of novel species and genes.
2015
science
It runs in the family
Science Detailed structural study shows distantly related viruses share a common machinery for replication.
2015
science
Taking out the trash
Science Unveiling the shape of... the 'molecular bin man' – cryoEM helps reveals p62 polymer in 3D.
2015
science
Stephen Cusack elected to the Royal Society
Lab Matters Stephen Cusack, head of EMBL Grenoble, among 47 new Royal Society fellows.
2015
lab-matters
PDBe launches new website
Lab Matters In their quest to make structural biology more accessible, PDBe launches a new website.
2015
lab-matters
How cells have got molecules surrounded
Science Ground-breaking microscopy technique gives unprecedented insight into endocytosis.
2015
science
Bypassing errors
Science Coin toss inspires CorMap: a new statistical test that sidesteps need for error estimation.
2015
science
Grenoble anniversary symposium: join us!
Alumni EMBL Grenoble celebrates 40 years with a symposium for staff, alumni and facility users on 4–5 June.
2015
alumni
Attack from all sides
Science Hamburg-led tuberculosis study demonstrates the power of collaboration.
2015
science
Shining light onto the fabric of life
Events First LearningLAB of 2015 makes science of protein structure crystal clear for 22 teachers.
2015
events
Come together
Science First experimental proof that a key cellular machine forms by uniting pre-assembled modules.
2015
science
Light years ahead
Science As EMBL Hamburg celebrates 40 years, we explore the past, present and future of crystallography.
2015
science
It all started with muscle…
Alumni Ken Holmes, one of the visionaries behind EMBL and EMBL Hamburg, looks back to where it all began.
2015
alumni
Welcome: Marco Marcia
Science New group leader Marco Marcia aims to broaden horizons while mapping molecules.
2015
science
‘Hairclip’ protein mechanism explained
Science Research led by Teichmann group identifies fundamental mechanism for controlling protein function.
2015
science
Lighting the way
Events EMBL Hamburg celebrates four decades of vision, pioneering research and beamline services.
2014
events
Dinner with a Nobel Laureate
Lab Matters The day EMBL Hamburg predocs and postdocs invited Nobel Prize Winner Ada Yonath to dinner.
2014
lab-matters
Four decades at EMBL
Alumni Employee number 47 retires, leaving behind a legacy that intricately linked her life with EMBL.
2014
alumni
MASSIF step forward
Science In two months, 2.3 million diffraction images collected on new, fully automated ESRF/EMBL beamline.
2014
science
What can your synchrotron do for you?
Events Life Science Nord event reveals how pharmaceutical companies use synchrotrons for their research.
2014
events
20 years in the making
Science First complete picture of flu virus polymerase. A story of two decades of blood, sweat and sneezes.
2014
science
Welcome: Kyung-Min Noh
Science The important thing is forming good biological questions, says new group leader in Genome Biology.
2014
science
On a SAXS quest
Events Course attendees go hunting (protein) aliens in a quest for optimal SAXS data.
2014
events
Same pieces, different picture
Science Unprecedented detail on HIV structure continues virus’ string of surprises.
2014
science
PEPC recipe for success
Events How to make good quality samples for good quality structural biology experiments.
2014
events
Breaking boundaries
Science How Nobel-winning work by alumnus Stefan Hell shapes and inspires current EMBL scientists' research.
2014
science
Awards & Honours
Lab Matters EMBL scientists regularly receive prestigious awards - meet the latest honourees
2014
lab-matters
Hamburg anniversary symposium: Preview
Events An interview with keynote speaker Michael Rossmann.
2014
events
CSSB foundation stone ceremony
Events Research building for interdisciplinary Centre for Structural Systems Biology (CSSB) takes shape.
2014
events
Binding bracelet
Science Vasa protein preserves pieces of 'enemy' DNA to help protect the genes of future generations.
2014
science
International connections
Science How a single molecule can attract and repel growing brain connections
2014
science
Fighting bacteria – with viruses
Science Molecular switch enables viruses to destroy C.diff bacteria – potential alternative to antibiotics
2014
science
Awards & Honours
Lab Matters EMBL scientists regularly receive prestigious awards - meet the latest honourees
2014
lab-matters
The future’s bright
Science Surprising protein from a flu-like virus is 10 000th ESRF structure
2014
science
The shape of things to come
Science New ways of handling and distributing data at PDBe to tackle ever larger and more complex proteins
2014
science
Five for the future
Lab Matters Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead
2014
lab-matters
Chain reactions
Science Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression
2014
science
Picky eaters: how microglia capture their prey
Science A kaleidoscope of molecules is needed to clean up dead brain cells, and failure can have disastrous consequences
2014
science
HIV: hacking, immaturity and viruses
Science High-resolution structure reveals crucial interactions for HIV maturation
2014
science
First, catch your DNA
Science DNA-coralling protein complex in an unexpected bind
2014
science
Choreographed origami
Science An important step in building ribosomes – the cell’s protein factories – is like a strictly choreographed dance, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. To build these factories, other ‘machines’ inside the cell have to…
2013
science
Protein production: going viral
Science A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today…
2013
science
Catching the cap-snatcher
Science Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus’ RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS…
2012
science
New distributed research infrastructure for structural biology
Science Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…
2012
science
A hot species for cool structures
Science A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus,…
2011
science
How cells export and embed proteins in the membrane
Science Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…
2010
science
How to shoot the messenger
Science Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…
2010
science
Putting the squeeze on sperm DNA
Science In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…
2009
science
Mapping the protein world
Lab Matters In the early days of X-ray crystallography obtaining a three-dimensional model of a protein required wire models, screws, bolts and years of tedious calculations by hand. Today macromolecular models are built by computers – thanks to sophisticated software and in particular a package called…
2006
lab-matters
The giant protein titin helps build muscles
Science Imagine grabbing two snakes by the tail so that they can’t wriggle off in opposite directions. Scientists at the Hamburg Outstation of the European Molecular Biology Laboratory (EMBL) and collaborators from King’s College in London have now discovered that something similar happens to a…
2006
science
A major European Centre for Structural Biology inaugurated in Grenoble
Lab Matters On Friday, 13 January 2006, the new Carl-Ivar Brändén Building (CIBB) will be inaugurated on the Polygone Scientifique Campus in Grenoble, France. The CIBB will be operated as a collaboration between major international and national partners based in Grenoble and is a further step in the…
2006
lab-matters
New high-throughput crystallization facility at EMBL Hamburg to give boost to structural biology community
Lab Matters Today the European Molecular Biology Laboratory (EMBL) opens a new highthroughput crystallization facility at its Outstation located on the campus of the German Synchrotron Radiation Facility (DESY) in Hamburg, Germany. The facility, made possible by major funds from the German Ministry for Science…
2005
lab-matters
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