press release

Cancer drug resistance causes and categories identified

Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.

A universal framework for spatial biology

Science & Technology SpatialData is a tool developed by EMBL scientists in cooperation with multiple research institutions to unify and integrate data from different omics technologies in a spatial environment, providing holistic insights into health and disease. Researchers can now freely access and use SpatialData…

‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention

Science & Technology New study uncovers the potential of immunotherapy in preventing breast cancer and creates the openly available Human Breast Cell Atlas.

The malaria parasite generates genetic diversity using an evolutionary ‘copy-paste’ tactic

Science & Technology Plasmodium falciparum, a malaria parasite, uses gene conversion to produce genetic diversity in two surface protein genes targeted by the human immune system.

Team SAMBAI: addressing cancer disparities in recent African heritage populations

Science & Technology An international team of researchers aim to combine social determinants of health with genomics, immune profiling, and exposomics data to tackle cancer inequities at an unprecedented scale.

The Biodiversity Cell Atlas: charting cellular diversity on Earth

A $3.8 million grant from the Gordon and Betty Moore Foundation will help researchers lay groundwork for the Biodiversity Cell Atlas.

UKRI funding supports EMBL-EBI infrastructure upgrade in response to increasing data demand

UK Research and Innovation (UKRI) has confirmed £80.7 million of funding for EMBL’s European Bioinformatics Institute (EMBL-EBI). The funding comes from the UKRI Infrastructure Fund and will be distributed over the course of six years. It is set to help EMBL-EBI transform its technical…

The Global Biodiversity Portal: enabling biodiversity research worldwide

Science & Technology The new initiative brings together genomic data from various biodiversity projects to aid conservation and biodiversity efforts.

EMBL-EBI co-leads on research programme to help treat relapsed childhood cancers

Leading charities Children with Cancer UK and Cancer Research UK will co-fund a major £5.5 million research programme to advance precision medicine for relapsed childhood cancers.

Genes, cells, and embryos in development and evolution: Pere Alberch, 25 years on

Connections Scientists from the MELIS department at UPF and EMBL Barcelona have organised a symposium to discuss the work of the visionary Catalan scientist Pere Alberch, who passed away 25 years ago.

Fighting antimicrobial resistance with new drug combinations

Science & Technology In an extensive investigation, EMBL researchers have tested over 10,000 drug combinations against some of the leading pathogenic bacteria carrying antimicrobial resistance and causing mortality. 

EMBL receives German AI prize

EMBL Announcements EMBL receives the German AI prize awarded for outstanding services to the research and development as well as application and commercialisation of artificial intelligence (AI) in life science research.

Uncovering the mechanisms underlying lack of response to immunotherapy 

Science & Technology New research improves understanding of the molecular mechanisms behind why some cancers respond to immunotherapy and others don't.

EMBL-EBI’s new building set to support data growth and innovative partnerships

EMBL AnnouncementsLab Matters Construction begins on EMBL-EBI's new building named after Janet Thornton.

Pathogens Portal: The new gateway to public pathogen data

Science & Technology Enabling researchers worldwide to share and analyse pathogen data generated across the world

David Hulcoop appointed as Open Targets Director

EMBL Announcements Coming from a pharmaceutical industry background, David Hulcoop is set to take over as Executive Director of the public-private partnership Open Targets.

The speed of life: a zoo of cells to study developmental time

Science & Technology Researchers from the Ebisuya Group at EMBL Barcelona have used an unprecedented stem cell zoo to compare six different mammalian species and their developmental time.

A more diverse human reference genome

Science & Technology The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.

Large-scale study enables new insights into rare eye disorders

EMBL-EBI researchers use UK Biobank data to uncover new information about rare diseases of the eye.

A human interactome to prioritise drug discovery

Researchers create a network of interacting proteins – or interactome – to aid drug discovery.

BlueRemediomics: harnessing marine microbes to promote a circular bioeconomy

Funding awarded for developing tools to harness marine microbiome data for biotechnological applications and ecosystem services.

Open Targets consortium welcomes Genentech as newest member

Open Targets announces that Genentech will become the seventh partner in the drug discovery and validation consortium.

New molecular microscopy uncovers how breast cancer spreads

Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads.

EMBL Barcelona and CRG kickstart new era of digital biology in Barcelona

ConnectionsLab Matters The institutes have launched a joint new initiative which aims to make biology as engineerable as an aeroplane or a bridge.

Biodiversity Genomics Europe: addressing biodiversity loss through genomics

European experts gather to launch a project that aims to characterise and conserve life on Earth using DNA data.

Official opening of the EMBL Imaging Centre

EMBL Announcements Representatives from politics, industry and academia attended the inauguration ceremony at EMBL Heidelberg

Shaping up the genome for cell division

Science & Technology Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.

Impact of DNA mutations on blood cell production uncovered

Science & Technology Researchers discover how DNA mutations change blood cell production and how this relates to ageing and cancer development.

Unravelling the origins of the human spine

Science & Technology Scientists at EMBL Barcelona have created for the first time a 3D in vitro model that recapitulates the periodic formation of human somites – structures that give rise to the spinal column.

An international study proposes stool analysis for early detection of pancreatic cancer

Science & Technology A molecular signature of 27 microorganisms in stool defines the high-risk population for the most common pancreatic cancer and could be used for early detection of the disease.

Pfizer joins the Open Targets consortium

Connections Open Targets, a consortium focused on drug target identification, prioritisation, and validation, announced today that Pfizer has joined as a partner.

EMBL welcomes NetApp in its Corporate Partner Programme

ConnectionsLab Matters EMBL welcomes NetApp, a leader in cloud data services empowering global organisations to change their world with data, as member of the Corporate Partnership Programme of the EMBL Advanced Training Centre.

DNA damage and faulty repair jointly cause mutations

Science & Technology DNA mutations are caused by a combination of DNA damage and repair, shows study by EMBL-EBI and collaborators.

Nordic EMBL Partnership awarded €210,000 funding

ConnectionsLab Matters The Nordic EMBL Partnership for Molecular Medicine has been awarded 210,000 euros. The funds will be used to train the next generation of specialists and research leaders in molecular medicine in the Nordic countries.

Unprecedented single-cell studies in virtual embryo

Science & Technology Researchers from EMBL Heidelberg have created a complete description of early embryo development, accounting for every single cell in the embryo.

Understanding brain tumours in children

Science & Technology The causes of 40 percent of all cases of certain medulloblastoma – dangerous brain tumours affecting children – are hereditary. These are the findings of a recent genetic analysis carried out by scientists from EMBL and numerous colleagues around the world.

€2.45 m to investigate leukaemia causes and therapies

EMBL Announcements The Heidelberg-based LeukoSyStem consortium investigates leukaemia stem cells in acute myeloid leukaemia. The German Federal Ministry of Education and Research financially supports this collaboration between Heidelberg University Hospital, HI-STEM gGmbH, the German Cancer Research Center and EMBL.

New technique for studying living fly larvae

Science & Technology This technique provides a simple but effective way to study the functions of organs in living animals

How females shut off their second X chromosome

Science & Technology Scientists provide important new insights into the molecular basis of X-inactivation

The Pan-Cancer project

Science & Technology EMBL co-leads most comprehensive study of genetic causes of cancer

Melting reveals drug targets in a living organism

Science & Technology EMBL scientists identify drug targets in blood and organs

EMBL co-develops new method that could facilitate cancer diagnosis

Science & Technology Researchers have developed a cheaper and faster method to check for genetic differences in individual cells

Innovative method delivers new insights into the stem cell microenvironment

Science & Technology Researchers have developed new methods to reveal the 3D-organisation of bone marrow at a single cell level

Machine learning finds critical phosphosites

Science & Technology Resource has implications for disease research

New chair of EMBL Council

EMBL AnnouncementsLab Matters Professor Eiríkur Steingrímsson will commence his initial one-year term as Chair of EMBL Council on 1 January 2020.

EMBL and Leica sign open innovation agreement

EMBL Announcements Unique long-term collaboration agreement to provide new imaging technologies

Integrating imaging research across Europe

ConnectionsLab Matters Euro-BioImaging now established as a European Research Infrastructure Consortium

EMBL spins the Sleeping Beauty transposase

Science & Technology New possibilities for gene therapies

Discover the research schooner Tara and her new microplastics mission in the Barcelona harbour on 4 October

EMBL Announcements When: Friday, 4 October at 16:30 – 18:00. Where: The press conference will be held on the Tara schooner at the Port Olímpic in Barcelona. What: A press conference on the new Tara mission on microplastics and Tara’s cooperation with EMBL.…

Discover the research schooner Tara and her new microplastics mission in the Old Port of Marseille on 27 September

EMBL Announcements What: A press conference on the new Tara mission on microplastics and the Tara Ocean Foundation’s cooperation with EMBL. The press briefing will be followed by a visit to the schooner.When: Friday 27 September at 13:00 CEST.Where: The press conference will be held on the Tara…

B cells linked to immunotherapy

Science & Technology Immunotherapy: the role of B cells

Discover the research schooner Tara and her new microplastics mission in the Rome harbour on 13 September

EMBL Announcements When: Friday 13 September at 14:30.Where: The press conference will be held on the Tara schooner at the Porto Turistico di Roma (Lungomare Duca degli Abruzzi, 84, 00121 Roma RM, Italy).What: A press conference on the new Tara mission on microplastics and the Tara Ocean Foundation’s…

MEG3 kissing loops essential for tumour suppression

Science & Technology MEG3 adopts a complex three-dimensional structure to fulfil its tumour suppressor function.

Understanding molecular mechanisms of ageing

Science & Technology Understanding how ageing works at a molecular level

Toxin responsible for Legionella growth identified

Science & Technology SidJ enforces a unique modification on human proteins and helps legionella grow.

Dieter Schwarz Foundation supports Life Science Alliance

EMBL Announcements Funding for EMBL | Stanford Life Science Alliance.

Rearranging chromosomes

Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

A new home for biological images

Science & Technology The BioImage Archive - EMBL-EBI's first dedicated imaging data resource

Discover the research schooner Tara and her new microplastics mission in the Hamburg harbour on 17 June

EMBL Announcements When: Monday 17 June at 10:30Where: The press conference will be held on the Tara schooner at the Sandtorhafen in the Hamburg harbourWhat: A press conference on the new Tara mission on microplastics and Tara’s cooperation with EMBL. A tour of the schooner will be organised with the…

Paving the way for new flu drugs

Science & Technology Snapshots of the flu virus replication machine in action

The origins of plastic pollution at sea

Science & Technology Tara Ocean Foundation launches the exploration of 10 European rivers

Sex and diet affect proteotype

Science & Technology EMBL scientists have discovered that the proteome is substantially affected by both sex and diet

Foundation stone laid for EMBL Imaging Centre

Lab Matters Foundation stone ceremony for world-class high-resolution microscopy centre in Heidelberg

Global microbial signatures for colorectal cancer

Science & Technology Colorectal cancer characterised by consistent changes in gut bacteria across continents, cultures and diets

Designer organelles bring new functionalities into cells

Science & Technology EMBL scientists create membraneless organelle to build proteins in living cell

Cell death trigger in tuberculosis bacteria

Science & Technology Suicide system in tuberculosis bacteria might hold key to treatment

Almost 2000 unknown gut bacteria discovered

Science & Technology Researchers identify novel gut bacteria species and call for more data from beyond Europe and North America

The web meets genomics: a DNA search engine for microbes

Science & Technology New search engine allows researchers to identify antibiotic resistance genes or mutations in real time

Funding for bioinformatics technical infrastructure

Lab Matters Enhancing the world's bioinformatics infrastructure

Facilitating transcontinental human data exchange

Science & Technology Federated data sharing will now be possible on an unprecedented scale

Hundreds of tiny robots grow bio-inspired shapes

Science & Technology Scientists build self-organising features into robot swarms to study shape formation

Using light to stop itch

Science & Technology EMBL researchers have found a way to stop itch with light in mice

Algorithm identifies gene–environment relationships

Science & Technology New algorithm will enhance understanding of relationship between genotype and environmental factors

Controlling organ growth with light

Science & Technology The De Renzis group investigated invagination, the first step of organ development in embryos.

More effective insulin thanks to first 3D image

Science & Technology New study reveals how to make therapeutic insulins more effective than they currently are

Ageing is visible in the way cells use glucose

Science & Technology Researchers from EMBL and Heidelberg University unveil the molecular mechanisms of ageing

First interactive model of human cell division

Science & Technology Real-time tracking of proteins during mitosis is now possible using a 4D computer model

€17 million fund to power European detection and imaging innovation pipeline

ConnectionsLab Matters ATTRACT initiative will fund 170 breakthrough detection and imaging ideas with market potential

PhenoMeNal: an online portal for metabolomics

Science & Technology Complex metabolomics analyses in the cloud

Understanding soil through its microbiome

Science & Technology First global survey of soil genomics reveals a war between fungi and bacteria

Parental chromosomes kept apart during first division

Science & Technology Mammalian life begins differently than we thought

Melting bacteria to decipher antibiotic resistance

Science & Technology EMBL scientists investigate how bacteria melt to study their reaction to drugs

Combining antibiotics changes their effectiveness

Science & Technology Combining antibiotics with each other, non-antibiotic drugs or food additives can alter their effectiveness

Flu’s response to new drug explored

Science & Technology EMBL scientists investigate how influenza virus responds to new drug treatment

Miniature testing of drug pairs on tumour biopsies

Science & Technology Combinations of cancer drugs can be quickly and cheaply tested using a novel microfluidic device

New insights into Turing patterns

Science & Technology EMBL scientists extend Turing’s theory to help understand how biological patterns are created

Personalised medicine: one data type is not enough

Science & Technology New computational method uses multi-omics analysis for personalised medicine

Constructing new tissue shapes with light

Science & Technology EMBL researchers guide the shape of cells and tissues with optogenetics

How wild species may benefit from mouse genetic data

Science & Technology Of mice and gorillas: using mouse data for conservation

Managing chronic pain with light

Science & Technology Scientists at EMBL Rome develop new method that uses light to manage neuropathic pain in mice

Dog microbiome closer to humans’ than expected

People & Perspectives Dog and human gut microbiomes have more similar genes and responses to diet than previously thought

Captured: microglia nibbling on brain synapses

Science & Technology For the first time, EMBL Rome researchers have captured microglia nibbling on brain synapses on film.

LifeTime – a visionary proposal for an EU Flagship

ConnectionsLab Matters Following the completion of the Human Genome Project  in 2001, scientists and the media described the genome as “the book of life”, holding the answers to the way genes are linked to disease. Yet, seventeen years later, we are still deciphering how cells interpret this book. Since…

Commonly used drugs affect our gut bacteria

Science & Technology One in four drugs with human targets inhibit the growth of bacteria in the human gut, and may promote antibiotic resistance, EMBL researchers report in Nature

Molecular cuisine for gut bacteria

Science & Technology EMBL scientists show how to grow a wide range of gut bacteria in the lab

Potential way to limit antibiotic resistance

Science & Technology EMBL scientists unravel the molecular basis of a major antibiotic resistance transfer mechanism

Chromatin usage reveals developmental trajectories

Science & Technology EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories

EMBL spinoff to help antibody discovery

Lab MattersScience & Technology New EMBL spinoff company Velabs Therapeutics aims to speed up discovery of therapeutic antibodies

Synchronised waves control embryonic patterning

Science & Technology EMBL scientists show that the rhythm between Wnt and Notch waves enables patterning in embryos.

Mapping molecules on people, fields and ATMs

Science & Technology Molecule mapping method raises interest in forensics, agriculture and microbiome studies

Funding agreed for imaging centre

Lab Matters German state and federal governments agree funding for microscopy centre at EMBL Heidelberg

EMBL Council selects next Director General

EMBL AnnouncementsLab Matters Edith Heard’s mandate scheduled to begin 1 January 2019

Cell changes drive breast cancer relapse

Science & Technology Hallmarks of residual breat cancer cells suggest new approaches for preventing relapse

EMBL spin-off Luxendo acquired by Bruker

ConnectionsLab Matters Accelerating researchers’ access to next-generation light-sheet microscopy

Embryos use ancient viral DNA

Science & Technology EMBL scientists detect important function of genetic sequence our ancestors assimilated from a virus

EMBL to open new site in Barcelona

EMBL AnnouncementsLab Matters Spanish government and EMBL sign agreement for new site

New EMBL and GSK collaboration

ConnectionsLab Matters GSK and EMBL have signed an agreement to enhance understanding of disease and drug mechanisms

Neural connection keeps instincts in check

Science & Technology EMBL scientists find out how the prefrontal cortex puts a break on instinctive behaviours

How flu steals your RNA

Science & Technology Understanding how the flu virus steals host RNA offers hope of new drugs

Study offers approach to treating pain

Science & Technology Research on the effect of nerve cell stiffness on sensitivity to touch could lead to new painkillers

Toxoplasma’s balancing act explained

Science & Technology Parasite’s method of rewiring our immune response leads to novel tool for drug tests

Spiral growth

Science & Technology What happens when plant's leaf-placing feedback loop isn't quite right

In pursuit of flat growth in leaves

Science & Technology EMBL scientists investigate how leaves grow flat to efficiently capture sunlight

Blocking the waste disposal unit

Science & Technology Detailed structure paves the way for more effective cancer therapies

The force is strong with embryo cells

Science & Technology Strength of contraction determines whether cells become embryo or placenta

How new HIV drugs lock virus in immaturity

Science & Technology Study provides insights into workings of new HIV drugs and how virus becomes resistant

Impact on EMBL of UK referendum to leave EU

EMBL AnnouncementsLab Matters The UK’s decision to leave the EU has no direct consequences for the UK’s membership of EMBL

Poo transplants better understood

Science & Technology Stool transplants: finding the right match important, EMBL study shows

Revealing structure of nuclear pore’s inner ring

Science & Technology First detailed structural description of all the rings of nuclear pores

Designing gene therapy

Science & Technology Information on structure of molecule used for genome engineering yields increased efficiency

Mothers and daughters

Science & Technology 1st real-time video of starfish egg cell eliminating crucial structures, to ensure embryo viability

Forgetting to learn

Science & Technology Neural mechanisms in mouse brains indicate that we actively forget as we learn

Forever young

Science & Technology How stem cells resist change

Turning point of a lifetime

Science & Technology New microscope can record the first days of a mouse embryo’s life

Drugging bacteria

Science & Technology Commonly used diabetes drug metformin impacts gut bacteria more than disease itself

Lighting up development

Science & Technology Using lasers to shed light on how tissues get into shape

Lighting the way

Lab MattersScience & Technology A microscopy technique is poised to shine new light on biological questions: as sheets of light can scan everything from developing embryos to single cells or functioning brains, a technique called light-sheet microscopy is gaining traction. It enables scientists to observe living cells in three…

Floppy but fast

Science & Technology Spaghetti-like proteins are surprisingly effective 'keys'

Finding links and missing genes

Science & Technology Missing a gene may not be a big deal – a conclusion from global catalogue of genetic changes.

Ages apart

Science & Technology Multifaceted approach reveals how brain and liver age, helps explain why ageing brain loses plasticity.

Life in 3D

Science & Technology EMBL scientists map ‘switches’ for distant control of gene expression.

Iron regulators join war on pathogens

Science & Technology Iron regulatory proteins play important role in combatting infection, protecting against Salmonella.

Oskar’s structure revealed

Science & Technology 3D structure of Oskar protein gives first molecular insight into how it functions.

Cell machinery wears complex coat

Science & Technology 3D imaging unravels COPI coat of cells' transport vesicles.

DNA protection, inch by inch

Science & Technology European team identify mechanism for producing piRNAs that silence jumping genes in germline cells.

Decades-old cell biology puzzle solved

Science & Technology Behaviour of clathrin proteins, crucial for endocytosis, is clarified using new imaging techniques.

Dancing with the cells

Science & Technology Cells 'dance' as they draw together during early embryo development.

Decaying RNA molecules tell a story

Science & Technology Decaying RNA molecules tell a story that could add more chapters to the study of ribosomes.

Oceans endeavour charts 40 million genes

Science & Technology Tara Oceans results reveal climate change insights, and a treasure trove of novel species and genes.

It runs in the family

Science & Technology Detailed structural study shows distantly related viruses share a common machinery for replication.

Sense of space

Science & Technology EMBL scientists demonstrate that spatial constraints are a key factor in determining nucleus size.

How cells have got molecules surrounded

Science & Technology Ground-breaking microscopy technique gives unprecedented insight into endocytosis.

No humans required

Science & Technology New fully automated technique enables scientists to chart complex protein networks in living cells.

New Joint Directors of EMBL-EBI

Lab Matters Rolf Apweiler and Ewan Birney appointed Joint Directors of EMBL-EBI, as Janet Thornton steps down.

Attack from all sides

Science & Technology Hamburg-led tuberculosis study demonstrates the power of collaboration.

The battle for iron

Science & Technology New way mice starve pathogens raises alternative approach to treatments for anaemia of chronic disease

Delighting in detail

Science & Technology Unprecedented detail in images of mouse neurons thanks to new SNAP-tagging microscopy technique.

20 years in the making

Science & Technology First complete picture of flu virus polymerase. A story of two decades of blood, sweat and sneezes.

Witamy! EMBL welcomes Poland as prospect member state

In a Statement of Intent signed this month, Poland becomes a prospect member state of EMBL, and the new partners agree to explore possibilities for long-term cooperation, with a view to the country becoming a full member state within three years. “Poland has a strong and active life science…

Same pieces, different picture

Science & Technology Unprecedented detail on HIV structure continues virus’ string of surprises.

Chamber of secrets

Science & Technology Like sports teams, cells can huddle to communicate in secret and organise group behaviour

Protecting us from our cells

Science & Technology Growth factor IGF-1 boosts natural defence against type-1 diabetes and multiple sclerosis

Hungary joins EMBL as prospect member state

The European Molecular Biology Laboratory (EMBL) welcomes Hungary as its newest prospect member state. In a Statement of Intent signed this month, Hungary and EMBL agree to explore possibilities for long-term cooperation, with a view to the country becoming a full member state within three years.…

How plankton gets jet lagged

Science & Technology How plankton gets jet lagged: the same hormone governs our sleep patterns and a daily marine migration.

From worm muscle to spinal discs

Science & Technology Evolutionary surprise: notochord likely evolved from muscle, earlier than assumed.

40 years learning from life

International connections

Science & Technology How a single molecule can attract and repel growing brain connections

Fighting bacteria – with viruses

Science & Technology Molecular switch enables viruses to destroy C.diff bacteria – potential alternative to antibiotics

Science meets politics

Connections Anniversary reflections on connections between scientific and political interests.

Surprisingly stable long-distance relationships

Science & Technology Surprising finding: enhancers find their targets long before activation in Drosophila embryos

Taken out of context

Science & Technology Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA

Czech Republic becomes EMBL’s 21st member state

EMBL Announcements Forty years after its foundation, EMBL announces its 21st member state: the Czech Republic. Building on a successful bilateral relationship, the Czech Republic’s membership grants Czech scientists access to EMBL’s state-of-the-art instruments, facilities and world-class training…

Insights into genetics of cleft lip

Science & Technology How a DNA stretch influences face formation and contributes to common congenital malformations

How immune cells use steroids

Science & Technology Genome Campus researchers discover that some immune cells turn themselves off by producing a steroid.

Argentina joins EMBL as associate member state

EMBL Announcements At a signing ceremony today, Argentina joins the European Molecular Biology Laboratory (EMBL) as an associate member state. The move strengthens the ties between the European and Latin American life science communities. It grants Argentinian scientists access to EMBL’s world-class facilities and…

Where do you start when developing a new medicine?

ConnectionsLab Matters A pioneering public-private research initiative between GSK, the European Bioinformatics Institute (EMBL-EBI) and the Wellcome Trust Sanger Institute is to harness the power of ‘big data’ and genome sequencing to improve the success rate for discovering new medicines. The new Centre for…

Slovak Republic becomes EMBL Prospect Member State

EMBL Announcements The European Molecular Biology Laboratory (EMBL) welcomes the Slovak Republic as the first country to join its new Prospect Member scheme. In a Statement of Intent signed last month, the Slovak Republic and EMBL agree to explore the possibilities for long-term cooperation, with a view to the…

Pan-European imaging infrastructure gains momentum

ConnectionsLab Matters Europe is uniting to make state-of-the-art imaging technologies accessible to biomedical researchers throughout the continent in a concerted manner. The European Molecular Biology Laboratory (EMBL) and seven countries (Belgium, Finland, Italy, Poland, Slovakia, the Netherlands, the United Kingdom)…

Making your brain social

Science & Technology In many people with autism and other neurodevelopmental disorders, different parts of the brain don’t talk to each other very well. Scientists have now identified, for the first time, a way in which this decreased functional connectivity can come about. In a study published online today…

UK invests £75 million in European research infrastructure to support knowledge-based economy

Lab Matters The European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) and the Biotechnology and Biological Sciences Research Council (BBSRC) warmly welcome today’s announcement from the UK Government of a £75 million commitment from the Department for Business, Innovation…

Intruder detected: raise the alarm!

Science & Technology When a thief breaks into a bank vault, sensors are activated and the alarm is raised. Cells have their own early-warning system for intruders, and scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered how a particular protein sounds that alarm when it…

Five countries and EMBL sign Memorandum of Understanding to make ELIXIR a reality

Lab Matters Today marks an important step for ELIXIR, Europe’s emerging research infrastructure for life-science information, as five countries plus the European Molecular Biology Laboratory (EMBL) have signed a Memorandum of Understanding to catalyse the implementation and construction of ELIXIR. The…

Fishing games gone wrong

Science & Technology When an egg cell is being formed, the cellular machinery which separates chromosomes is extremely imprecise at fishing them out of the cell’s interior, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. The unexpected degree of trial-and-error…

Live from the scene: biochemistry in action

Science & Technology Researchers can now watch molecules move in living cells, literally millisecond by millisecond, thanks to a new microscope developed by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Published online today in Nature Biotechnology, the new technique provides…

Gardening in the brain

Science & Technology Gardeners know that some trees require regular pruning: some of their branches have to be cut so that others can grow stronger. The same is true of the developing brain: cells called microglia prune the connections between neurons, shaping how the brain is wired, scientists at the European…

A hot species for cool structures

Science & Technology A fungus that lives at extremely high temperatures could help understand structures within our own cells. Scientists at the European Molecular Biology Laboratory (EMBL) and Heidelberg University, both in Heidelberg, Germany, were the first to sequence and analyse the genome of a heat-loving fungus,…

Obituary – Lennart Philipson

Lab Matters Lennart Philipson, who served as EMBL’s second Director General, has passed away. Lennart headed EMBL for over a decade between 1982-93, a crucial time for molecular biology when different scientific disciplines in the life sciences were becoming increasingly interlinked. He reorganised the…

Keeping it together

Science & Technology As any rock-climber knows, trailing a long length of rope behind you is not easy. A dangling length of rope is unwieldy and hard to manoeuvre, and can get tangled up or stuck on an outcropping. Cells face the same problem when dragging chromosomes apart during cell division. The chromosomes are…

What’s your gut type?

Science & Technology In the future, when you walk into a doctor’s surgery or hospital, you could be asked not just about your allergies and blood group, but also about your gut type. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and collaborators in the international MetaHIT…

The informant: a jumping gene

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have developed a new method for studying gene regulation, by employing a jumping gene as an informant. Published online today in Nature Genetics, the new method is called GROMIT. It enables researchers to…

Small code change, big effect

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have developed a new method which enables researchers to label any protein of their choice with any of a wide variety of previously available compounds, in living cells, by introducing a single reactive…

Suggesting genes’ friends, facebook-style

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Centre (DKFZ), both in Heidelberg, Germany, have developed a new method that uncovers the combined effects of genes. Published online today in Nature Methods, it helps understand how different genes can…

European Commission and EMBL renew cooperation

Lab Matters In a Memorandum of Understanding signed today, the European Commission (EC) and the European Molecular Biology Laboratory (EMBL) formalise their desire to maintain and further develop their cooperation. “I am delighted to sign the renewed and strengthened Memorandum of Understanding between the…

Two in one

Science & Technology In a paper published online today in PNAS, scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, reveal new insights into the workings of enzymes from a group of bacteria including Mycobacterium tuberculosis, the bacterium that causes tuberculosis. The new findings…

BBSRC and EMBL-EBI welcome UK funds earmarked for major bioscience data infrastructure project

Lab Matters The Biotechnology and Biological Sciences Research Council (BBSRC) and the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) welcome news that funding has been earmarked from the UK’s Large Facilities Capital Fund for ELIXIR – the European Life-science…

Blood-clotting protein linked to cancer and septicaemia

Science & Technology In our not-so-distant evolutionary past, stress often meant imminent danger, and the risk of blood loss, so part of our body’s stress response is to stock-pile blood-clotting factors. Scientists in the Molecular Medicine Partnership Unit (MMPU), a collaboration between the European Molecular…

The human genome’s breaking points

Science & Technology A detailed analysis of data from 185 human genomes sequenced in the course of the 1000 Genomes Project, by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, in collaboration with researchers at the Wellcome Trust Sanger Institute in Cambridge, UK, as well as the…

Intelligent microscopy

Science & Technology The sight of a researcher sitting at a microscope for hours, painstakingly searching for the right cells, may soon be a thing of the past, thanks to new software created by scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Presented today in Nature Methods, the…

How cells export and embed proteins in the membrane

Science & Technology Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…

Better imaging from bench to bedside

Science & Technology From microscopy to computer tomography (CT) scans, imaging plays an important role in biological and biomedical research, but obtaining high-quality images often requires advanced technology and expertise, and can be costly. Euro-BioImaging, a project which launches its preparatory phase today,…

One-touch make-up – for our cells

Science & Technology The cells in the different parts of this video are always the same (grey), but, like actors using make-up to highlight different facial features, they have fluorescent labels that mark different cellular components in different colours: blue shows the nucleus, yellow shows tubulin (a component of…

European XFEL joins EIROforum

Lab Matters At the Autumn 2010Council meeting of the EIROforum, a partnership of seven European intergovernmental research organisations with large research infrastructures, the Directors General unanimously accepted the European X-Ray Free-Electron Laser Facility (European XFEL), based in Hamburg, Germany, to…

1000 Genomes Project ushers in new era for human genetics

Science & Technology The 1000 Genomes Project, a major international collaboration to build a detailed map of human genetic variation, has completed its pilot phase. The results are now published in the journal Nature and freely available through the European Molecular Biology Laboratory’s European Bioinformatics…

Brainy worms: Evolution of the cerebral cortex

Science & Technology Our cerebral cortex, or pallium, is a big part of what makes us human: art, literature and science would not exist had this most fascinating part of our brain not emerged in some less intelligent ancestor in prehistoric times. But when did this occur and what were these ancestors? Unexpectedly,…

Freeze or run? Not that simple

Science & Technology Fear can make you run, it can make you fight, and it can glue you to the spot. Scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy and GlaxoSmithKline in Verona, Italy, have identified not only the part of the brain but the specific type of neurons that determine…

Constant overlap

Science & Technology During cell division, microtubules emanating from each of the spindle poles meet and overlap in the spindle’s midzone. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have uncovered the molecular mechanism that determines the extent of this overlap. In a…

Supply and demand

Science & Technology Most organisms need iron to survive, but too much iron is toxic, and can cause fatal organ failure. The same is true inside cells, where iron balance must also be maintained. In a study published today in Cell Metabolism, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg,…

Digital Embryo gains wings

Science & Technology The scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, who ‘fathered’ the Digital Embryo have now given it wings, creating the Fly Digital Embryo. In work published today in Nature Methods, they were able to capture fruit fly development on film, and were the…

A life-changing partnership

Science & Technology Researchers from the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Max-Planck Institute of Immunobiology Freiburg have identified a novel protein complex that regulates around 4000 genes in the fruit fly Drosophila and likely plays an important role in mammals, too.…

Making enough red blood cells

Science & Technology Red blood cells, the delivery men that take oxygen to cells all around the body, have short lives. To keep enough of them in circulation, the human body produces around 2 million of these cells every second – even more in response to challenges like severe blood loss. In a study published today…

Tags on, tags off

Science & Technology During embryonic development, proteins called Polycomb group complexes turn genes off when and where their activity must not be present, preventing specialised tissues and organs from forming in the wrong places. They also play an important role in processes like stem cell differentiation and…

Variations on the genetic theme

Science & Technology Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties. By integrating gene expression data from…

Movies for the human genome

Science & Technology Name a human gene, and you’ll find a movie online showing you what happens to cells when it is switched off. This is the resource that researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and their collaborators in the Mitocheck consortium are making freely…

What makes us unique? Not only our genes

Science & Technology Once the human genome was sequenced in 2001, the hunt was on for the genes that make each of us unique. But scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and Yale and Stanford Universities in the USA, have found that we differ from each other mainly because…

The Nordic EMBL Partnership for Molecular Medicine officially inaugurates the Institute for Molecular Medicine Finland in Helsinki

Lab Matters Today, the Nordic EMBL Partnership for Molecular Medicine officially inaugurates the Institute for Molecular Medicine Finland (FIMM) in Helsinki. Together with the Centre for Molecular Medicine Norway (NCMM, University of Oslo) and the Laboratory for Molecular Infection Medicine Sweden (MIMS, Umeå…

New training and conference centre for the life sciences at EMBL in Heidelberg

Lab Matters Today, the German Minister for Education and Research, Annette Schavan, officially opens the new training and conference centre for the life sciences on the campus of the European Molecular Biology Laboratory (EMBL) in Heidelberg. “This new centre in Heidelberg will form a central European…

Bacterial balance that keeps us healthy

Science & Technology The thousands of bacteria, fungi and other microbes that live in our gut are essential contributors to our good health. They break down toxins, manufacture some vitamins and essential amino acids, and form a barrier against invaders. A study published today in Nature shows that, at 3.3 million,…

MicroRNA: a glimpse into the past

Science & Technology The last ancestor we shared with worms, which roamed the seas around 600 million years ago, may already have had a sophisticated brain that released hormones into the blood and was connected to various sensory organs. The evidence comes not from a newly found fossil but from the study of microRNAs…

How to shoot the messenger

Science & Technology Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

Membrane-coat proteins: bacteria have them too

Science & Technology Although they are present almost everywhere, on land and sea, a group of related bacteria in the superphylum Planctomycetes-Verrucomicrobia-Chlamydiae, or PVC, have remained in relative obscurity ever since they were first described about a decade ago. Scientists at the European Molecular Biology…

Open access drug discovery database launches with half a million compounds

Science & Technology ChEMBLdb, a vast online database of information on the properties and activities of drugs and drug-like small molecules and their targets, launches today with information on over half a million compounds. The data lie at the heart of translating information from the human genome into successful new…

The Battle of the Sexes

Science & Technology Is it a boy or a girl? Expecting parents may be accustomed to this question, but contrary to what they may think, the answer doesn’t depend solely on their child’s sex chromosomes. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany and the Medical Research…

From fruit fly wings to heart failure. Why Not(ch)?

Science & Technology Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…

First-ever blueprint of a minimal cell is more complex than expected

Science & Technology What are the bare essentials of life, the indispensable ingredients required to produce a cell that can survive on its own? Can we describe the molecular anatomy of a cell, and understand how an entire organism functions as a system? These are just some of the questions that scientists in a…

Drought resistance explained

Science & Technology Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…

Deciphering the regulatory code

Science & Technology Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes.…

From foe to friend: mosquitoes that transmit malaria may help fight the disease

Science & Technology For many years, the mosquitoes that transmit malaria to humans were seen as public enemies, and campaigns to eradicate the disease focused on eliminating the mosquitoes. But, as a study published today in Science shows, the mosquitoes can also be our allies in the fight against this common foe,…

Putting the squeeze on sperm DNA

Science & Technology In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…

To regenerate muscle, cellular garbage men must become builders

Science & Technology For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, published online this week in the journal Proceedings of the National Academy of Sciences (PNAS), provide…

How stem cells make skin

Science & Technology Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

UK leads European research programme with £10M investment in bioscience data handling capacity

Lab Matters BBSRC has awarded funding to the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), based at Hinxton near Cambridge, to permit a dramatic increase in the institute’s data storage and handling capacity. The funding is the first step in developing the existing…

Raising the alarm when DNA goes bad

Science & Technology Our genome is constantly under attack from things like UV light and toxins, which can damage or even break DNA strands and ultimately lead to cancer and other diseases. Scientists have known for a long time that when DNA is damaged, a key enzyme sets off a cellular ‘alarm bell’ to alert the…

Scientists open doors to diagnosis of emphysema

Science & Technology Chronic inflammatory lung diseases like chronic bronchitis and emphysema are a major global health problem, and the fourth leading cause of death and disability in developed countries, with smoking accounting for 90% of the risk for developing them. Work by scientists at the European Molecular…

Scientists identify cholesterol-regulating genes

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) and the University of Heidelberg, Germany, have come a step closer to understanding how cholesterol levels are regulated. In a study published today in the journal Cell Metabolism, the researchers identified 20 genes that are involved…

New interdisciplinary structural biology centre for virus research and technology platforms

Lab Matters On June 26 2009 the joint international Unit for Virus and Host Cell Interactions (Unité Mixte Internationale) was formally established in Grenoble. The unit is run jointly by CNRS, the Grenoble outstation of the European Molecular Biology Laboratory (EMBL) and the Grenoble University Joseph…

Uncovering how cells cover gaps

Science & Technology Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, came a step closer to understanding how cells close gaps not only during embryonic development but also during wound healing. Their study, published this week in the journal Cell, uncovers a fundamental…

New electron microscopy images reveal the assembly of HIV

Science & Technology Scientists at the European Molecular Biology Laboratory (EMBL) and the University Clinic Heidelberg, Germany, have produced a three-dimensional reconstruction of HIV (Human Immunodeficiency Virus), which shows the structure of the immature form of the virus at unprecedented detail. Immature HIV is…

European centre of excellence for mouse biology celebrates its 10th anniversary

Lab Matters Mice are one of biology’s most important model organisms, because 98% of their genes and many of their traits and diseases are similar to ours. Researchers at the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) take advantage of these similarities and use mice to study…

New EMBL service makes web browsing efficient for biologists

Science & Technology The life sciences are scaling up and produce huge amounts of data and new literature at an amazing pace. The European Molecular Biology Laboratory (EMBL) now offers a new free service to help researchers, teachers and students keep up-to-date with scientific literature on the web, especially when…

Sugarcoating fruit fly development

Science & Technology Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…

Getting a grip on complexes: EMBL scientists develop first fully automated pipeline for multiprotein complex production

Science & Technology Most cellular processes are carried out by molecular machines that consist of many interacting proteins. These protein complexes lie at the heart of life science research, but they are notoriously hard to study. Their abundance is often too low to extract them directly from cells and generating…

Recycler protein helps prevent disease

Science & Technology Recycling is important not only on a global scale, but also at the cellular level, since key molecules tend to be available in limited numbers. This means a cell needs to have efficient recycling mechanisms. Researchers at the European Molecular Biology Laboratory (EMBL) and Heidelberg University,…

New study reveals the protein that makes phosphate chains in yeast

Science & Technology It can be found in all life forms, and serves a multitude of purposes, from energy storage to stress response to bone calcification. This molecular jack-of-all trades is polyphosphate, a long chain of phosphate molecules. Researchers at the European Molecular Biology Laboratory (EMBL) in…

Picture Release

Science & Technology ‘Useless fish with big eyes’. This is what Medaka, the name of the Japanese killifish in the pictures, means in Japan where it originally comes from. While its eyes are undeniably big, the fish has proven remarkably useful for scientists. It is a simple model organism, amenable to…

New findings reveal how influenza virus hijacks human cells

Science & Technology Influenza is and remains a disease to reckon with. Seasonal epidemics around the world kill several hundred thousand people every year. In the light of looming pandemics if bird flu strains develop the ability to infect humans easily, new drugs and vaccines are desperately sought. Researchers at…

Re-write the textbooks: transcription is bidirectional

Science & Technology Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. The same is true for many other organisms that are easier to study than humans. Researchers in the groups of Lars Steinmetz at the…