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grenoble

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3 November 2022 View from above of a small room with several tools, cables and pieces of technology. A rectangular box, a robotic arm and a device are highlighted in green.

Two in one: combining MASSIF-1 and CrystalDirect

Lab Matters Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.

2022

lab-matters

27 April 2022 Portrait of Kristina Djinović-Carugo

Next Head of EMBL Grenoble appointed

Lab Matters Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…

2022

lab-matters

27 April 2022 Kristina Djinović-Carugo sitting at her desk.

Meet the next Head of EMBL Grenoble

Lab Matters Slovenian structural biologist Kristina Djinović-Carugo will join EMBL in July as the new Head of EMBL Grenoble. We spoke to her about her background, research interests, and plans for EMBL Grenoble.

2022

lab-matters

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

Lab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

2021

lab-matters

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

2021

science

7 October 2021 SARS-CoV-2 and planet Earth are merged together in this illustration

Six Ways to Protect the Planet Against Pandemics*

Events EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.

2021

events

8 July 2021 Two men stand outside in front of a building, holding a document and looking at it.

A hidden medal

Alumni We all like a story about rediscovering treasures, right? Well, that’s just what happened recently at EMBL Grenoble!

2021

alumni

8 June 2021 Two scientists in lab coats working on an instrument in the lab.

EMBL external research community survey

Lab Matters EMBL is conducting an Impact Assessment of our experimental services to understand the value these services have for our external user community. If you have accessed EMBL experimental services at one or more of our facilities to support the conduct of your research, we would like to hear from you.

2021

lab-matters

9 March 2021 This photo shows the European Photon and Neutron (EPN) science campus on the peninsula at the confluence of the Isère and Drac rivers, where EMBL Grenoble is located.

Touch of springtime in Grenoble

Picture of the week This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.

2021

picture-of-the-week

9 February 2021 Crystal cubes seen through a microscope

Purity, beauty, and perfection

Picture of the week The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.

2021

picture-of-the-week

12 January 2021 Three images showing close-ups of different EMBL facilitites.

EMBL becomes newest Instruct Centre

Lab Matters EMBL’s sites in Grenoble, Hamburg, and Heidelberg form the newest Instruct Centre. The new centre offers users access to a broad range of state-of-the-art facilities.

2021

lab-matters

2 December 2020 Curly-shaped trypanosomes, grey with bright specks of green fluorescent protein, against a grey background.

Tackling tropical diseases

Science Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness

2020

science

8 July 2020 The Logo of the ALPX company.

ALPX – smart crystallography

Lab Matters The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.

2020

lab-matters

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

science

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Science Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

2020

science

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Science EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

science

29 April 2020 The Influenza virus

Understanding the influenza virus

Science The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

2020

science

10 March 2020

It’s Lab Ski Day!

Picture of the week This image, taken by Raphaël Cohen-Aberdam from the Cipriani team, shows that the weather for the Grenoble Lab Ski Day 2020 was just perfect!

2020

picture-of-the-week

29 November 2019 Choanocyte chamber of sponge, with neuroid cell

Neural pathways

Science Exploring the diverse routes by which EMBL scientists are driving forward neurobiology

2019

science

26 September 2019 The Old Port of Marseille.

EMBL and Tara: Marseille

Events From 27–30 September, Tara will be docked in the port of Marseille, France’s second largest city.

2019

events

17 September 2019

The end of a productive day

Picture of the week It’s evening and the Sun is setting over the mountains surrounding the city of Grenoble – home to one of EMBL’s six sites – bathing the mountaintops in fiery red light. The Picture of the Week, taken by Zuzanna Kaczmarska shows the lab she worked in after a long and busy day. Bottles…

2019

picture-of-the-week

31 May 2019 EMBL scientists in a bar for the event Pint of Science

A thirst for science

Events EMBL got together with the global science festival Pint of Science to explain and celebrate science.

2019

events

30 August 2016 Francesco Iorio, an EMBL-EBI/Sanger Interdisciplinary Postdoc and now a senior bioinformatician at EMBL-EBI, strives to be "a great dad, as well as a great researcher". PHOTO: Robert Slowley

Postdocs of EMBL

Lab Matters Turning the spotlight on the diverse universe of EMBL’s 200-strong postdoc community

2016

lab-matters

30 August 2016

Atomic proportions

Science EMBL and ESRF scientists and mechanics work together on upgrade for one of Europe’s big X-ray sources

2016

science

16 June 2016 Emiko Uchikawa in her lab at EMBL in Grenoble. IMAGE: Isabelle Kling/EMBL

Found in translation

Science Studying at EMBL in Grenoble helps Japanese postdoc see her native country through different eyes

2016

science

17 December 2015

What’s on in 2016

Events With 28 conferences and 57 courses, 2016 will be EMBL’s most eventful year to date.

2015

events

25 November 2015

Humans of EMBL

Lab Matters Compelling short stories that shine light on the life and work of EMBL staff.

2015

lab-matters

22 September 2015

MASSIFly efficient

Science MASSIF-1 processes its 10,000th crystal, less than one year after the beamline became operational.

2015

science

24 August 2015

Molecular momentum

Alumni Andrew Miller, first head of EMBL Grenoble, reflects on four decades at the Outstation.

2015

alumni

13 July 2015

EIPOD goes cubic

Lab Matters EI3POD: flagship interdisciplinary postdoc programme opens its doors to academia and industry.

2015

lab-matters

21 May 2015

It runs in the family

Science Detailed structural study shows distantly related viruses share a common machinery for replication.

2015

science

27 January 2015 Building blocks TAF8 (blue), TAF10 (green) and TAF2 (not shown) form a module in the cytoplasm before entering the nucleus to form TFIID. IMAGE: EMBL/I.BERGER

Come together

Science First experimental proof that a key cellular machine forms by uniting pre-assembled modules.

2015

science

28 November 2014

MASSIF step forward

Science In two months, 2.3 million diffraction images collected on new, fully automated ESRF/EMBL beamline.

2014

science

19 November 2014

20 years in the making

Science First complete picture of flu virus polymerase. A story of two decades of blood, sweat and sneezes.

2014

science

20 August 2014

Binding bracelet

Science Vasa protein preserves pieces of 'enemy' DNA to help protect the genes of future generations.

2014

science

1 July 2014 Illustration: Aad Goudappel, Rotterdam

Five for the future

Lab Matters Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead

2014

lab-matters

25 June 2014

Chain reactions

Science Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression

2014

science

13 October 2013

Choreographed origami

Science An important step in building ribosomes – the cell’s protein factories – is like a strictly choreographed dance, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. To build these factories, other ‘machines’ inside the cell have to…

2013

science

6 January 2013

Protein production: going viral

Science A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today…

2013

science

2 August 2012 Different inhibitors (yellow, grey) fill the cave-like active site of the cap-snatching protein (the endonuclease, in green) differently, even though they all bind to the active site’s two metal ions (magenta).

Catching the cap-snatcher

Science Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus’ RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS…

2012

science

21 June 2012

Flu fighters

Science Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This…

2012

science

23 February 2012

New distributed research infrastructure for structural biology

Science Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…

2012

science

13 October 2011 In the absence of viral RNA (top), the part of RIG-I that senses viral RNA is exposed (orange), whilst the domains responsible for signalling (blue and pink) are out of reach of the signalling machinery. When RIG-I detects viral RNA, it changes shape (bottom), and the signalling domains become accessible to sound the alarm.

Intruder detected: raise the alarm!

Science When a thief breaks into a bank vault, sensors are activated and the alarm is raised. Cells have their own early-warning system for intruders, and scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered how a particular protein sounds that alarm when it…

2011

science

12 December 2010 This cryo-electron microscopy image shows the 3D structure of the ribosome (yellow/blue) bound to the signal recognition particle (SRP) and the SRP receptor (both in red). Below it is an atomic model of SRP (green-yellow/orange) and its receptor (pink). Image credits: EMBL/Schaffitzel.

How cells export and embed proteins in the membrane

Science Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…

2010

science

26 January 2010 This image shows the three-dimensional structure of Death-Associated Protein Kinase (green and yellow) when bound to calmodulin (violet and blue). It was obtained by X-ray crystallography. Image credit: Mathias Wilmanns / EMBL

How to shoot the messenger

Science Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…

2010

science

8 November 2009

Drought resistance explained

Science Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…

2009

science

30 September 2009 In the centre, a structural model determined by X-ray crystallography shows how the two tags (attached to a short section of the histone protein – all in cyan) fit neatly into the Brdt pocket (purple). In the background image, hypercompaction by Brdt causes relatively diffuse chromatin (stained blue inside the nuclei of two cells on the top left) to compact and clump together (two on the bottom right).

Putting the squeeze on sperm DNA

Science In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…

2009

science

4 February 2009 High resolution image of the key domain of the influenza virus polymerase. The active site responsible for RNA cleavage is shown in red. Its activity is crucial for the virus to multiply in human cells

New findings reveal how influenza virus hijacks human cells

Science Influenza is and remains a disease to reckon with. Seasonal epidemics around the world kill several hundred thousand people every year. In the light of looming pandemics if bird flu strains develop the ability to infect humans easily, new drugs and vaccines are desperately sought. Researchers at…

2009

science

4 May 2008

Getting wise to the influenza virus’ tricks

Science Influenza is currently a grave concern for governments and health organisations around the world. Now one of the tactics used by influenza virus to take over the machinery of infected cells has been laid bare by structural biologists at the EMBL, the joint Unit of Virus Host-Cell Interaction of…

2008

science

25 February 2007

A first glimpse of the influenza replication machine

Science In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world. There is great concern that this virus might also…

2007

science

16 June 2006

Cracking a virus protection shield

Science Ebola, measles and rabies are serious threats to public health in developing countries. Despite different symptoms all of the diseases are caused by the same class of viruses that unlike most other living beings carry their genetic information on a single RNA molecule instead of a double strand of…

2006

science

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