RNA in action: filming a ribozyme’s self-assembly
Researchers have visualised, in unprecedented detail, how a large RNA molecule assembles itself into a functional machine.
SCIENCE & TECHNOLOGY2025
science-technology
From the lab bench to the community: enjoying a day of activities around science and ‘intelligences’
EMBL Grenoble took part once again in Parvis des Sciences, highlighting EMBL efforts towards engaging more with the public and the importance of the human factor in AI development.
LAB MATTERS2025
lab-matters
EMBL celebrates 50 years of its French site
Together with institutional partners, alumni, and collaborators who have been part of EMBL scientific journey over the years, participants engaged in insightful discussions and reflected on EMBL Grenoble's key scientific milestones.
LAB MATTERS2025
lab-matters
Knowledge exchange between continents supports infection biology research
African scientists awarded the 2024 EMBL-UNESCO residencies share their experience in bioinformatics and virology, emphasising the power of connections and knowledge exchange.
CONNECTIONSPEOPLE & PERSPECTIVES2025
connectionspeople-perspectives
Splicing twins: unravelling the secrets of the minor spliceosome complex
Researchers in the Galej Group at EMBL Grenoble have provided new insights into the structure of the minor spliceosome, an essential RNA-protein complex.
SCIENCE & TECHNOLOGY2025
science-technology
Structural insights reveal drug target in trypanosome parasites
The Kowalinski group at EMBL Grenoble identified significant differences between the trypanosomal and human nuclear cap-binding complex, a key player in cellular RNA metabolism and a potential target for novel anti-parasitic drugs.
SCIENCE & TECHNOLOGY2025
science-technology
Cute molecules and the scientists who adore them: Sarah Gharbi
Sarah Gharbi, technician at EMBL Grenoble, talks about her favourite protein complex, which looks like a poodle. This is part of a series of stories about EMBL scientists and quirky, charming proteins that make them smile.
PEOPLE & PERSPECTIVES2025
people-perspectives
We are EMBL: Romain Linares on the infinitely small and the infinitely large
Romain Linares talks about his role in managing the cryo-electron microscopy facility at EMBL Grenoble, how he sees this technique evolving in the coming years, and his passion for astronomy.
PEOPLE & PERSPECTIVES2024
people-perspectives
Diving into the world of science
EMBL Grenoble took part in a series of activities during the French Science Week, highlighting EMBL’s research and the TREC scientific expedition.
LAB MATTERS2024
lab-matters
Making in situ serial crystallography more accessible
Nicolas Foos, a postdoctoral fellow at EMBL Grenoble, talks about the implementation of a new method for in situ serial crystallography developed during his ARISE fellowship.
SCIENCE & TECHNOLOGY2024
science-technology
“Structurally” sound
The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.
SCIENCE & TECHNOLOGY2024
science-technology
Computational protein design and protein structure prediction win Nobel Prize in Chemistry
Creators of AI system AlphaFold receive 2024 Nobel Prize for Chemistry.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
New insights on how bird flu crosses the species barrier
A new publication from the Cusack group sheds light on how a key avian influenza virus enzyme can mutate to allow the virus to replicate in mammals.
SCIENCE & TECHNOLOGY2024
science-technology
Developing a simple, cost-effective method to study an important protein modification
EMBL Grenoble researchers have come up with a new way to identify the targets of a crucial protein-modifying enzyme involved in diverse cellular processes.
SCIENCE & TECHNOLOGY2024
science-technology
We are EMBL: Melanie Schneider on changing career trajectory
ARISE fellow Melanie Schneider shares how she uncovered a new interest in research infrastructures and supporting discovery.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Celebrating 50 years of infinite curiosity
What makes EMBL unique? Among many things, it’s the infinite curiosity of its community.
LAB MATTERS2024
lab-matters
IIT-EMBL: New molecules to modulate gene expression
A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.
SCIENCE & TECHNOLOGY2024
science-technology
An enzyme with a smart friend
EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…
SCIENCE & TECHNOLOGY2024
science-technology
AI approaches in structural biology and drug discovery
EMBL Grenoble and the ESRF hosted a workshop bringing together representatives from research and industry to discuss the ever-growing role of artificial intelligence in the field of structural biology.
CONNECTIONS2024
connections
We are EMBL: Elise Bralet on the importance of connecting people
Elise talks about her role in supporting EMBL Grenoble staff in daily human resources matters and the multiple events she’s been involved in to connect people, both at and outside of work.
PEOPLE & PERSPECTIVES2024
people-perspectives
Stephen Cusack: what I’ve learned
Stephen Cusack, world-renowned structural biologist and former Head of EMBL Grenoble, reflects on his early influences, his achievements, and the lessons he’s learned as he embarks on his next adventure
PEOPLE & PERSPECTIVES2024
people-perspectives
Building the cell’s splicing machine
New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.
SCIENCE & TECHNOLOGY2024
science-technology
Studying the relationship between cancer-promoting proteins
A new study from the Bhogaraju Group at EMBL Grenoble reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
EMBL and UGA signed the renewal of their agreement for the delivery of a doctoral degree
The two institutions celebrated the renewal of the partnership agreement initiated in 1999 for the delivery of a doctoral degree and a joint training certificate during UGA’s Welcome Day for doctoral students.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
We are EMBL: Victor Armijo on instrumentation in supporting research
Victor Armijo, a mechatronics engineer at EMBL Grenoble, talks about his dream job, highlighted in EMBL’s exhibition ‘The World of Molecular Biology’.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Looking back on 20 years of structural biology collaboration in Grenoble
On this date (15 November), 21 years ago, the EMBL, ESRF, ILL, and IBS directors signed a memorandum of understanding to create the Partnership for Structural Biology (PSB) on the European Photon and Neutron (EPN) science campus in Grenoble.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
Enjoying a science day in Grenoble
EMBL Grenoble was once again present for the science outreach event ‘Parvis des Sciences’ on Saturday 14 October 2023.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
A promising target to fight inflammatory bowel diseases
Researchers from the Cusack group at EMBL Grenoble provide structural insights on the XIAP/RIPK2 complex, a promising drug target to fight inflammatory bowel diseases.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Celebrating Stephen Cusack’s contributions to science
Researchers from across the globe have gathered in Grenoble to celebrate the remarkable lifelong scientific achievements of Stephen Cusack, the former head of EMBL Grenoble.
PEOPLE & PERSPECTIVES2023
eventspeople-perspectives
Switching off the cytokine storm
EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
We are EMBL: Rutuja Yelmar on her life as a PhD student at EMBL Grenoble
Rutuja Yelmar, predoctoral Fellow at EMBL Grenoble in the Kowalinski group, talks about her passion for research, daily inspiration, and the importance of collaboration in achieving her goals.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Spotlight: Shedding light on deadly parasites
This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterspicture-of-the-weekscience-technology
Facilitating drug discovery against COVID-19
A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
IMAGINE-ing next-generation technology to help biologists
EMBL researchers and collaborators have begun an impactful innovation-development journey, thanks to a European Commission ‘IMAGINE’ grant.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
We are EMBL: Martin Pelosse on his role at the Eukaryotic Expression Facility
Martin Pelosse, Scientific Expert at EMBL Grenoble Eukaryotic Expression Facility, explains the platform’s role in supporting the site’s cutting-edge research activities and its future applications.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Behind the scenes of innovation
EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.
EMBLetc2023
We are EMBL: Angelika Thomasson on administrative support to EMBL staff
Angelika Thomasson, administrative assistant at EMBL Grenoble, talks about her role in supporting her colleagues in organising events and travels, what she enjoys about EMBL, and which famous female scientist she would like to have coffee with.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
We are EMBL: Audrey Spielmann on providing lab support
Audrey Spielmann, Lab Support Manager, talks about her role in supporting the research done at EMBL Grenoble.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Welcome: Gergely Papp
Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
EMBL Grenoble showcased at Biophysical Society Meeting
EMBL’s French site was highlighted in a short film presenting its expertise in structural biology research and services.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
Biology meets engineering
Physicists, engineers and robotics experts work together in EMBL Hamburg’s Instrumentation Team to design instruments that support structural biology research. The team has finished a transfer robot that facilitates automated handling of protein crystals with care and precision. This will help…
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
New EU-funded Project: Fragment-Screen
EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Solving the structure of a critical molecular editor
EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
New molecular insights on medical cannabis
EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Celebrating science in Grenoble
In October 2022, EMBL Grenoble participated in the annual science outreach event Parvis des Sciences, organised by the GIANT campus under the umbrella of the French science week – La Fête de la science.
CONNECTIONSLAB MATTERS2022
connectionslab-matters
Getting closer to stopping toxoplasmosis infection
Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Two in one: combining MASSIF-1 and CrystalDirect
Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Teaming up to drive forward time-resolved crystallography
The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Patrick Cramer elected as next President of the Max Planck Society
Former chair of EMBL Council to take office as the next President of the Max Planck Society in June 2023.
EMBL ANNOUNCEMENTS2022
alumniembl-announcements
Next Head of EMBL Grenoble appointed
Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…
EMBL ANNOUNCEMENTSLAB MATTERS2022
embl-announcementslab-matters
Meet the next Head of EMBL Grenoble
Slovenian structural biologist Kristina Djinović-Carugo will join EMBL in July as the new Head of EMBL Grenoble. We spoke to her about her background, research interests, and plans for EMBL Grenoble.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Capturing ‘snapshots’ of a crucial step in RNA splicing
The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
EMBL-IAB collaboration on the rise
The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Solving molecular puzzles to find the perfect fit
Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Strengthening collaborations in France
EMBL and the French National Centre for Scientific Research (CNRS) signed a memorandum of understanding.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Wrangling an octopus-like viral replication machine
EMBL structural biology is part of an international collaboration addressing zoonotic disease caused by Lassa virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL experimental services enable European researchers to tackle global societal challenges
Independent impact review finds EMBL experimental services are ‘critical’ for research and endorses EMBL as a world-class service provider for academia and industry.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
EMBL and Ifremer cooperate to advance ocean sciences
The two organisations have signed a memorandum of understanding to support scientific cooperation in the exploration of coastal and oceanic ecosystems.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Six Ways to Protect the Planet Against Pandemics*
EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.
SCIENCE & TECHNOLOGY2021
eventsscience-technology
MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery
MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
A hidden medal
We all like a story about rediscovering treasures, right? Well, that’s just what happened recently at EMBL Grenoble!
PEOPLE & PERSPECTIVES2021
alumnipeople-perspectives
EMBL external research community survey
EMBL is conducting an Impact Assessment of our experimental services to understand the value these services have for our external user community. If you have accessed EMBL experimental services at one or more of our facilities to support the conduct of your research, we would like to hear from you.
LAB MATTERS2021
lab-matters
EMBL and Inserm to join forces
A memorandum of understanding has been signed between EMBL and Inserm to strengthen their scientific cooperation.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
EMBL and Tara Ocean Foundation sail forward with formalised cooperation
The EMBL-Tara Ocean Foundation collaboration will expand opportunities to jointly explore molecular connections between ocean and humankind.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
EMBL strengthens collaborations in the French academic landscape
A memorandum of understanding has been signed between EMBL, Collège de France, and the Institute of Biology of the Ecole Normale Supérieure (IBENS).
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Structural biology at EMBL: driving technology development
Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
From molecules to ecosystems: EMBL and IAB sign memorandum of understanding
This MoU formalises a 15-year collaboration between the two institutes and strengthens Grenoble as a European research centre in the life sciences.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
Touch of springtime in Grenoble
This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.
LAB MATTERS2021
lab-matterspicture-of-the-week
Purity, beauty, and perfection
The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
At the core of the Integrator complex
A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL becomes newest Instruct Centre
EMBL’s sites in Grenoble, Hamburg, and Heidelberg form the newest Instruct Centre. The new centre offers users access to a broad range of state-of-the-art facilities.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
First powder over EMBL Grenoble
The first snowflakes have fallen on the Vercors Mountains, right behind the EMBL Grenoble building, and an almost full moon is showing up during a sunny morning.
LAB MATTERS2020
lab-matterspicture-of-the-week
Tackling tropical diseases
Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL forms new collaborations in France
EMBL and CIML have signed a memorandum of understanding that will open up new scientific opportunities.
CONNECTIONSLAB MATTERS2020
connectionslab-matters
EMBL scientists receive prestigious ERC Starting Grants
Maria Bernabeu and Wojciech Galej have each been awarded €1.5 million to research malaria and pre-mRNA splicing, respectively.
EMBL ANNOUNCEMENTSLAB MATTERS2020
embl-announcementslab-matters
Upgraded beamlines at EMBL Grenoble unveiled
The beamlines run jointly by EMBL Grenoble and the ESRF reopen today, unveiling significant upgrades that exploit the brand new fourth generation ESRF synchrotron source.
EMBL ANNOUNCEMENTS2020
embl-announcementsscience
ALPX – smart crystallography
The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.
LAB MATTERS2020
lab-matters
Investigating the structure and mechanisms of coronavirus biomolecules
While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Genetic cut and paste at atomic resolution
Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Novel method sheds new light on tumour-suppressing RNA
Researchers from EMBL Grenoble have developed a way to visualise large RNAs in 3D using biochemical and structural biology techniques.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Facilitating COVID-19 structural biology research
EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…
CONNECTIONS2020
connectionsscience
Responding to health threats posed by coronaviruses
By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Remote access to EMBL structural biology pipelines to support research on SARS-CoV-2
The Marquez Team has restarted operations at the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble. The team has developed a fully automated protein-to-structure pipeline, which can be operated remotely and provides virtual access to the facilities.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding the influenza virus
The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
It’s Lab Ski Day!
This image, taken by Raphaël Cohen-Aberdam from the Cipriani team, shows that the weather for the Grenoble Lab Ski Day 2020 was just perfect!
LAB MATTERS2020
lab-matterspicture-of-the-week
Empowering European structural biology
EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology
EMBL ANNOUNCEMENTSLAB MATTERS2019
embl-announcementslab-matters
Strengthening European biology
EMBL is now a member of the Instruct-ERIC organisation
LAB MATTERS2019
announcementslab-matters
Neural pathways
Exploring the diverse routes by which EMBL scientists are driving forward neurobiology
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Snapshots from Mission Microplastics
Highlights from the Tara stopovers in Rome, Marseille, and Barcelona
EMBL ANNOUNCEMENTS2019
embl-announcementsevents
EMBL and Tara: Marseille
From 27–30 September, Tara will be docked in the port of Marseille, France’s second largest city.
EMBL ANNOUNCEMENTS2019
embl-announcementsevents
The end of a productive day
It’s evening and the Sun is setting over the mountains surrounding the city of Grenoble – home to one of EMBL’s six sites – bathing the mountaintops in fiery red light. The Picture of the Week, taken by Zuzanna Kaczmarska shows the lab she worked in after a long and busy day. Bottles…
LAB MATTERS2019
lab-matterspicture-of-the-week
Discover the research schooner Tara and her new microplastics mission in the Old Port of Marseille on 27 September
What: A press conference on the new Tara mission on microplastics and the Tara Ocean Foundation’s cooperation with EMBL. The press briefing will be followed by a visit to the schooner.When: Friday 27 September at 13:00 CEST.Where: The press conference will be held on the Tara…
EMBL ANNOUNCEMENTS2019
embl-announcementsevents
EMBL in France: where science meets the sea
September’s alumni event in Marseille will coincide with a Tara stopover
PEOPLE & PERSPECTIVES2019
alumnipeople-perspectives
MEG3 kissing loops essential for tumour suppression
MEG3 adopts a complex three-dimensional structure to fulfil its tumour suppressor function.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Toxin responsible for Legionella growth identified
SidJ enforces a unique modification on human proteins and helps legionella grow.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
EIPOD4: 2019 applications are open
EIPOD4 will prepare researchers for the increasing interdisciplinarity of scientific career paths
EMBL ANNOUNCEMENTSLAB MATTERS2019
embl-announcementslab-matters
Paving the way for new flu drugs
Snapshots of the flu virus replication machine in action
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A thirst for science
EMBL got together with the global science festival Pint of Science to explain and celebrate science.
LAB MATTERS2019
eventslab-matters
Welcome: Sagar Bhogaraju
New group leader at EMBL Grenoble is investigating the cellular role of melanoma antigens
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Edith Heard starts as Director General of EMBL
On January 1 2019, Edith Heard takes up the position of EMBL’s Director General
LAB MATTERSPEOPLE & PERSPECTIVES2019
lab-matterspeople-perspectives
Transcription factors controlled by DNA sequence
EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Cohesin: a glue for DNA
EMBL scientists discover how a component of the cohesin ring binds DNA
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Humans of EMBL: Outreach
Discover how EMBLers across all sites share their passion for science
LAB MATTERSPEOPLE & PERSPECTIVES2018
lab-matterspeople-perspectives
Flu’s response to new drug explored
EMBL scientists investigate how influenza virus responds to new drug treatment
SCIENCE & TECHNOLOGY2018
sciencescience-technology
A pint of EMBL science
EMBL and Pint of Science join forces to entertain and educate
LAB MATTERS2018
eventslab-matters
Humans of EMBL: Past lives
Discover the past lives and journeys that brought people to EMBL
LAB MATTERSPEOPLE & PERSPECTIVES2018
lab-matterspeople-perspectives
Beamline ID23-2 tools up for ESRF upgrade
EMBL instrumentation teams adapting tech to run biological experiments on the synchrotron after its upgrade
LAB MATTERSSCIENCE & TECHNOLOGY2018
lab-mattersscience-technology
One way crossing across the midline
EMBL researchers solve a decades-long debate on a key process for brain and embryo-development
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Your favourite reads of 2017
A look back at some of the most read stories on EMBL’s news website this year
LAB MATTERS2017
lab-matters
Futures: Unravelling influenza
ERC grantee Stephen Cusack shares his vision for the next ten years
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Enzymes’ superimposable structures revealed
EMBL scientists superimpose structures of two-metal-ion enzymes and reveal new potential drug targets
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Welcome: Eva Kowalinski
New group leader based in Grenoble aims to unveil the mechanisms of RNA editing
PEOPLE & PERSPECTIVES2017
people-perspectivesscience
Humans of EMBL: Curiosity
EMBLers across all sites share how their curiosity about the world shapes their everyday life
LAB MATTERS2017
lab-matters
EMBL and ESRF renew collaboration agreement
EMBL and the European synchrotron ESRF extend their Joint Structural Biology Group
CONNECTIONSLAB MATTERS2017
connectionslab-matters
Supercool structures: new cryo-EM facility
As a new cryo-EM facility is inaugurated, EMBL’s Michael Hons describes his role in the project
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Cyclists rise to charity challenge
EMBL’s cycling team complete epic journey to raise money for Heidelberg’s children’s hospital
LAB MATTERS2017
lab-matters
Humans of EMBL: Senses
People across EMBL’s sites reflect on the ways they perceive their world
LAB MATTERSPEOPLE & PERSPECTIVES2017
lab-matterspeople-perspectives
Beamline 14’s legacy
Beamline BM14 in Grenoble shuts down, continues collaboration with India
LAB MATTERSSCIENCE & TECHNOLOGY2017
lab-mattersscience-technology
Welcome: Wojciech Galej
New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression
PEOPLE & PERSPECTIVES2017
people-perspectivesscience
How flu steals your RNA
Understanding how the flu virus steals host RNA offers hope of new drugs
SCIENCE & TECHNOLOGY2016
sciencescience-technology
New Crystallography platform inaugurated
A new crystallography platform in Grenoble opens the door to new technological developments
EMBL ANNOUNCEMENTSLAB MATTERS2016
embl-announcementslab-matters
Toxoplasma’s balancing act explained
Parasite’s method of rewiring our immune response leads to novel tool for drug tests
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Big data, cool servers
Upgraded server room is ready to take the heat at EMBL Grenoble
LAB MATTERS2016
lab-matters
New drug candidate unleashed for TB
EMBL researchers help to design a lead compound active against four different pathogens
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Opinion: 2006, a year of champagne
Stephen Cusack looks back on the early days of his collaboration with Anacor developing anti-infectives
LAB MATTERSPEOPLE & PERSPECTIVES2016
lab-matterspeople-perspectives
Opinion: A journey from bench to clinical trials
Andrés Palencia on the design of compounds that may help fight drug-resistant TB and more
LAB MATTERSPEOPLE & PERSPECTIVES2016
lab-matterspeople-perspectives
Postdocs of EMBL
Turning the spotlight on the diverse universe of EMBL’s 200-strong postdoc community
LAB MATTERSPEOPLE & PERSPECTIVES2016
lab-matterspeople-perspectives
Atomic proportions
EMBL and ESRF scientists and mechanics work together on upgrade for one of Europe’s big X-ray sources
CONNECTIONS2016
connectionsscience
Found in translation
Studying at EMBL in Grenoble helps Japanese postdoc see her native country through different eyes
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Partnership for Structural Biology: strength in diversity
Grenoble-based Partnership for Structural Biology (PSB) renewed for five more years
CONNECTIONSLAB MATTERS2016
connectionslab-matters
Enzyme with a dual-purpose loop
Unexpected results: structure of DAPK enzyme reveals dual-purpose loop
SCIENCE & TECHNOLOGY2016
sciencescience-technology
The man behind the machine
Florent Cipriani talks about his passion for developing beamline instrumentation
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Crystals in the beamlight
CrystalDirect, developed at EMBL, automates crystal preparation for X-ray analysis
SCIENCE & TECHNOLOGY2016
sciencescience-technology
A cohesive structure
Structural insights into how cohesin keeps DNA together during the cell cycle
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Obituary: Bernard Jacrot
Former Head of EMBL Grenoble passed away on 21 January 2016 at the age of 89
PEOPLE & PERSPECTIVES2016
alumnipeople-perspectives
What’s on in 2016
With 28 conferences and 57 courses, 2016 will be EMBL’s most eventful year to date.
CONNECTIONS2015
connectionsevents
Humans of EMBL
Compelling short stories that shine light on the life and work of EMBL staff.
LAB MATTERSPEOPLE & PERSPECTIVES2015
lab-matterspeople-perspectives
MASSIFly efficient
MASSIF-1 processes its 10,000th crystal, less than one year after the beamline became operational.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Molecular momentum
Andrew Miller, first head of EMBL Grenoble, reflects on four decades at the Outstation.
PEOPLE & PERSPECTIVES2015
alumnipeople-perspectives
EMBL Grenoble: Alumni stories
Alumni Reuben Leberman, Jeremy Smith, Elena Seiradake, and Winfried Weissenhorn share their stories.
PEOPLE & PERSPECTIVES2015
alumnipeople-perspectives
EIPOD goes cubic
EI3POD: flagship interdisciplinary postdoc programme opens its doors to academia and industry.
EMBL ANNOUNCEMENTSLAB MATTERS2015
embl-announcementslab-matters
DNA protection, inch by inch
European team identify mechanism for producing piRNAs that silence jumping genes in germline cells.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
From mountains to molecules
Staff, alumni, partners and more meet at EMBL Grenoble to celebrate Outstation's 40th anniversary.
LAB MATTERS2015
eventslab-matters
Open access: transforming science
EMBL’s new open access policy aims to make EMBL research widely and freely accessible.
LAB MATTERS2015
lab-matters
It runs in the family
Detailed structural study shows distantly related viruses share a common machinery for replication.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Stephen Cusack elected to the Royal Society
Stephen Cusack, head of EMBL Grenoble, among 47 new Royal Society fellows.
LAB MATTERS2015
lab-matters
Grenoble anniversary symposium: join us!
EMBL Grenoble celebrates 40 years with a symposium for staff, alumni and facility users on 4–5 June.
LAB MATTERS2015
alumnilab-matters
Shining light onto the fabric of life
First LearningLAB of 2015 makes science of protein structure crystal clear for 22 teachers.
LAB MATTERS2015
eventslab-matters
Come together
First experimental proof that a key cellular machine forms by uniting pre-assembled modules.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
Welcome: Marco Marcia
New group leader Marco Marcia aims to broaden horizons while mapping molecules.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
MASSIF step forward
In two months, 2.3 million diffraction images collected on new, fully automated ESRF/EMBL beamline.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
20 years in the making
First complete picture of flu virus polymerase. A story of two decades of blood, sweat and sneezes.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Zombies and crystals
Open Day in Grenoble celebrates crystallography for the Fête de la Science.
SCIENCE & TECHNOLOGY2014
eventsscience-technology
100 different stories
Drumming, drama, dancing and discovery in a diary of art and science event, Roche Continents.
LAB MATTERS2014
lab-matters
Binding bracelet
Vasa protein preserves pieces of 'enemy' DNA to help protect the genes of future generations.
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Celebrating 40 years of leading life science
"Thank you, EMBL, for changing my life" – reunion celebrates great science and great scientists
LAB MATTERS2014
alumnilab-matters
Forty things that make EMBL – Part 1
As the Lab turns 40, staff and alumni share 40 things that make EMBL, EMBL
LAB MATTERS2014
lab-matters
The future’s bright
Surprising protein from a flu-like virus is 10 000th ESRF structure
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Forty things that make EMBL – Part 2
As the Lab turns 40, staff and alumni share 40 things that make EMBL, EMBL
LAB MATTERS2014
lab-matters
Five for the future
Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead
LAB MATTERS2014
lab-matters
Chain reactions
Scientists determine the structure of auxin response factors: daisy-chains that regulate gene expression
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Choreographed origami
An important step in building ribosomes – the cell’s protein factories – is like a strictly choreographed dance, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. To build these factories, other ‘machines’ inside the cell have to…
SCIENCE & TECHNOLOGY2013
sciencescience-technology
Protein production: going viral
A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today…
SCIENCE & TECHNOLOGY2013
sciencescience-technology
Catching the cap-snatcher
Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus’ RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS…
SCIENCE & TECHNOLOGY2012
sciencescience-technology
Flu fighters
Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This…
SCIENCE & TECHNOLOGY2012
sciencescience-technology
New distributed research infrastructure for structural biology
Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…
SCIENCE & TECHNOLOGY2012
sciencescience-technology
Intruder detected: raise the alarm!
When a thief breaks into a bank vault, sensors are activated and the alarm is raised. Cells have their own early-warning system for intruders, and scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered how a particular protein sounds that alarm when it…
SCIENCE & TECHNOLOGY2011
sciencescience-technology
How cells export and embed proteins in the membrane
Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
How to shoot the messenger
Cells rely on a range of signalling systems to communicate with each other and to control their own internal workings. Scientists from the European Molecular Biology Laboratory (EMBL) in Hamburg, Germany, have now found a way to hack into a vital communications system, raising the possibility of…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
Drought resistance explained
Much as adrenaline coursing through our veins drives our body’s reactions to stress, the plant hormone abscisic acid (ABA) is behind plants’ responses to stressful situations such as drought, but how it does so has been a mystery for years. Scientists at the European Molecular Biology…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
Putting the squeeze on sperm DNA
In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
New interdisciplinary structural biology centre for virus research and technology platforms
On June 26 2009 the joint international Unit for Virus and Host Cell Interactions (Unité Mixte Internationale) was formally established in Grenoble. The unit is run jointly by CNRS, the Grenoble outstation of the European Molecular Biology Laboratory (EMBL) and the Grenoble University Joseph…
LAB MATTERS2009
lab-matters
Getting a grip on complexes: EMBL scientists develop first fully automated pipeline for multiprotein complex production
Most cellular processes are carried out by molecular machines that consist of many interacting proteins. These protein complexes lie at the heart of life science research, but they are notoriously hard to study. Their abundance is often too low to extract them directly from cells and generating…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
New findings reveal how influenza virus hijacks human cells
Influenza is and remains a disease to reckon with. Seasonal epidemics around the world kill several hundred thousand people every year. In the light of looming pandemics if bird flu strains develop the ability to infect humans easily, new drugs and vaccines are desperately sought. Researchers at…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
Getting wise to the influenza virus’ tricks
Influenza is currently a grave concern for governments and health organisations around the world. Now one of the tactics used by influenza virus to take over the machinery of infected cells has been laid bare by structural biologists at the EMBL, the joint Unit of Virus Host-Cell Interaction of…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
A first glimpse of the influenza replication machine
In 1918, 50 million people died during a worldwide influenza pandemic caused by mutation of a bird-specific strain of the influenza virus. Recently H5N1, another highly infectious avian strain has caused outbreaks of bird flu around the world. There is great concern that this virus might also…
SCIENCE & TECHNOLOGY2007
sciencescience-technology
Cracking a virus protection shield
Ebola, measles and rabies are serious threats to public health in developing countries. Despite different symptoms all of the diseases are caused by the same class of viruses that unlike most other living beings carry their genetic information on a single RNA molecule instead of a double strand of…
SCIENCE & TECHNOLOGY2006
sciencescience-technology
A major European Centre for Structural Biology inaugurated in Grenoble
On Friday, 13 January 2006, the new Carl-Ivar Brändén Building (CIBB) will be inaugurated on the Polygone Scientifique Campus in Grenoble, France. The CIBB will be operated as a collaboration between major international and national partners based in Grenoble and is a further step in the…
LAB MATTERS2006
lab-matters
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