Events archive

8 October 2025

Evolution of the accessory genome

Description The accessory genome the set of genes variably present across members of a bacterial species plays a central role in shaping microbial diversity and adaptation Instead of a random collection of mobile elements evidence has shown that the accessory genome is structured by selective forces particularly negative frequency dependent selection and underpins the long term stability of multi strain bacterial populations Accessory loci are implicated in host interactions inter bacterial competition and responses to clinical interventions such as vaccination and antibiotic consumption making them a cradle of adaptive potential In this webinar we will explore how accessory genomes evolve why their composition remains stable despite turnover of lineages and how this evolutionary perspective allows us to better understand pathogen persistence and predict responses to selective pressures...

2 October 2025

A guide to UniProt for students

Description UniProt provides the scientific community with a comprehensive high quality and freely accessible resource of protein sequence and functional information This webinar will guide you through ways in which students and researchers at all career stages may take a structured approach to access the data in the UniProtKB and Proteomes sections of the UniProt protein function database The webinar will discuss the types of data that can be accessed and using sequence analysis tools how this data can be analysed to answer biological questions We will demonstrate how to find the function of a protein how the protein components of a pathway may be identified features of proteins of interest can be compared similar sections of sequence can be sought in other species and how whole data sets containing all the proteins expressed in an organism can be obtained By accessing sequence structural and functional data through UniProt we want researchers to be part of data s biological journey and support further work and adventures along the way...

1 October 2025

Introduction to pangenomes and why they are worth exploring

Description Pangenomes offer an alternative approach to using a singular linear reference genome which is becoming increasingly important as both the volume and diversity of genomic data grows rapidly However transitioning to pangenomics also brings along new terminology and challenges both biological and computational all of which are less clearly defined than in the conventional linear reference world Here we ll attempt to define some key differences in pangenomics and how they can improve future genomic analyses...

30 September 2025

A life in science: farewell symposium for Anne Ephrussi

Description OverviewSpeakersProgrammePractical InformationMedia kit Overview This conference will take place at EMBL Heidelberg Conference overview This special one day symposium to celebrate the distinguished career and many achievements of one of our most esteemed colleagues Anne Ephrussi From leading EMBL s developmental biology research unit to setting new directions for the organisation s training offerings Anne has made an indelible mark on European life sciences Anne s academic path began at Harvard University for her undergraduate studies followed by Massachusetts Institute of Technology MIT where she earned her PhD After two postdocs at Harvard University and the Whitehead Institute MIT she began her career at EMBL In 1992 she launched her EMBL research group Using the oskar gene as a paradigm her team focused on understanding how RNA molecules are transported and their translation regulated in animal development and how the germ plasm forms and induces germline formation Anne was actively involved in shaping EMBL s training programmes and in 2005 became Head of the newly created EMBL International Centre for Advanced Training EICAT In this role she oversaw EMBL s predoctoral and postdoctoral programmes as well as EMBL s courses and conferences She served as Associate Dean and then Dean of the PhD Programme and was instrumental in developing what is now the EMBL Postdoctoral Programme At the same time she led EMBL s Developmental Biology Unit from 2007 to 2021 whose focus she oriented towards organismal morphogenesis Anne s formal accolades are numerous She was elected to the French Acad mie des Sciences in 2008 and to the US Academy of Sciences in 2022 In 2023 Anne received the Society for Developmental Biology Lifetime Achievement Award and a year later the FEBS EMBO Women in Science Award We are thrilled to bring together many of Anne s key scientific colleagues collaborators and friends for a memorable day of talks and exchange to mark her formal retirement Speakers Alexander Aulehla EMBL Heidelberg Germany Florence Besse Institut de Biologie Valrose France Elena Conti Max Planck Institute of Biochemistry Germany Denis Duboule CIRB Coll ge de France France Eileen Furlong EMBL Heidelberg Germany Ruth Lehmann Massachusetts Institute of Technology and Whitehead Institute USA Christiane N sslein Volhard Max Planck Institute for Developmental Biology Germany Joel Richter The University of Massachusetts Medical School USA Erin Schuman Max Planck Institute for Brain Research Germany Trudi Sch pbach Princeton University USA Daniel St Johnston The University of Cambridge UK Pavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany Scientific organisers Alexander Aulehla EMBL Heidelberg Germany J rgen Deka EMBL Heidelberg Germany Eileen Furlong EMBL Heidelberg Germany Edith Heard The Francis Crick Institute UK Conference organiser Chris Stocks EMBL Heidelberg Germany Programme Please note that the programme is subject to change Some speakers may need to join virtually to give their talk Please keep checking back as the programme is currently being updated This event is taking place in the Operon building during the day Day 1 Tuesday 30 September 2025 Time Europe Berlin Speaker09 30 10 00Registration and light refreshmentsOperon Foyer10 00 10 15Opening remarks Alexander Aulehla Eileen Furlong and Edith Heard10 15 10 35Life without Hox genesDenis Duboule CIRB College de France France10 35 10 55Cycles on cycles collective rhythms during developmentAlexander Aulehla EMBL Heidelberg Germany10 55 11 15Look upstream Before RNA there is Genome Regulation Eileen Furlong EMBL Heidelberg Germany11 15 11 45Coffee break11 45 12 05mRNA localization in Drosophila memory circuitsFlorence Besse Institut Valrose France12 05 12 25The Fragile X SyndromeJoel Richter UMass USA12 25 12 45Messages and Machines at Neuronal SynapsesErin Schuman Max Planck Institute for Brain Research Germany12 45 14 15Lunch14 15 14 35Animal Beauty Function and Evolution of Biological AestheticsChristianne N sslein Volhard Max Planck Institute for Developmental Biology Germany14 35 14 55Talk title tbaDaniel St Johnston Gurdon Institute UK14 55 15 15Decoding RNA localization and translational control celebrating Anne Ephrussi s influence on the fieldGertrud Schupbach Princeton USA15 15 15 35Talk title tbaPavel Tomancak Max Planck Institute for Molecular Cell Biology Genetics Germany15 35 16 05Coffee break16 05 16 25Life after OskarRuth Lehmann MIT Department of Biology USA16 25 16 45Talk title tbaElena Conti Max Planck Institute of Biology Germany16 45 17 05Presentation by EICAT17 05 17 15Closing remarks Alexander Aulehla Eileen Furlong and Edith Heard 17 15 17 25Final remarks by Anne Ephrussi17 25 18 00Pre dinner drinks Operon foyer18 00 20 00DinnerEMBL Canteen20 00 22 00After dinner drinks farewell speechesATC roof top lounge Practical Information Registration fees On site registration is open to EMBL staff and alumni and is free of charge to attend Registration for the onsite symposium is on a first come first served basis and capacity is limited There are two types of registration Registration to attend the symposium only includes admission lunch and coffee breaks Registration to attend both the symposium and symposium dinner includes admission lunch coffee breaks and symposium dinner with drinks Virtual registration is not available for this event Abstract submission There will be no abstract submissions or posters for this symposium Accommodation and travel Accommodation is not included in the symposium registration As changes to events are possible you are advised to consider booking flights trains and hotels with flexible options and favourable cancellation conditions Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue There is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time More detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 PPT Slide 16 9 Social 1080 1350 Social 1600 900...

Alexander Aulehla, Jürgen Deka, Edith Heard

29 September - 2 October 2025

CANCELLED: NicE-RNA sequencing for multiomics on open chromatin and transcription

Description OverviewSpeakersPreliminary programmeSponsorsMedia kit Overview Update on cancellation Thank you for your interest in the EMBL Course on NicE RNA sequencing for multiomics on open chromatin and transcription Unfortunately due to product release delays we are not able to host this course in September 2025 and have to cancel the event If you would like to receive further details on the product protocol please feel free to contact the NEB Senior Application Manager Dr Bj rn Textor To stay in contact with us you can visit www embl org events for a complete list of all EMBL events and subscribe for our newsletter at www embl de events newsletter Course overview This course will focus on the latest state of the art novel library preparation protocols We will start with experimental design focusing on hands on library preparation including best practices standards and potential pitfalls concluding with sequencing of libraries bioinformatic evaluation best practices Multiomic data in scientific projects have become more and more important NicE Seq is a novel method enabling detection of open chromatin in fixed low numbers of cells without any additional instrumentation Combining open chromatin with transcriptome information is crucial for interpretation of cellular states Therefore the course participants will also prepare mRNA libraries from the same cell populations Participants will carry out a complete workflow from isolation of DNA RNA from fixed cells library preparation for both applications and shallow sequencing The course will discuss alternative novel approaches various cell fixatives and their impact on analysis In addition we will cover basic bioinformatic tools required for data processing quality control and initial data analysis Beside the practical exercises lectures and discussion sessions the course will offer the opportunity to learn more about transferring the knowledge gained during the course to the participants home institutes Audience This course is directed towards wet lab biologists scientists and technicians who want to apply the here offered technology Modules resources Hands on training on NGS multiome library preparations with upcoming state of the art reagents Setting up a sequencing run Basics in data handling and analysis Learning outcomes Multiome genomic analyses have become important to understand genome dynamics Methodology to explore this is still challenging and requires a lot of experience and hands on time During the course its participants will learn to apply novel NEBNext NGS library preparation reagents and protocols learn about the benefits and bottlenecks of different library preparations be exposed to cutting edge sequencing technology What past participants say about this course I really enjoyed this course both practical and invited lectures This was an interesting course format and I will apply the techniques I learned during the course in my project This is an extremely valuable course and I recommend this course to my colleagues Thanks to the EMBL organizers for making such a wonderful event successful Kesava Priyan Parmasamy Ulmea University Sweden Speakers Speakers trainers and staff Vladimir Benes EMBL Heidelberg Germany Mathias Boulanger EMBL Heidelberg Germany Alicia He New England Biolabs Germany Ferris Jung EMBL Heidelberg Germany Keerthana Krishnan New England Biolabs Germany Chaithanya Ponnaluri New England Biolabs Germany Jan Provaznik EMBL Heidelberg Germany Karin Prummel EMBL Heidelberg Germany Chen Song New England Biolabs Germany Bj rn Textor New England Biolabs Germany Laura Villacorta EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg Germany Scientific organisers Vladimir Benes EMBL Heidelberg Germany Bj rn Textor New England Biolabs Germany Laura Villacorta EMBL Heidelberg Germany Course organisers Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Ad la Graf Course and Conference Officer EMBL Heidelberg Germany Karo Wolkersdorfer Course and Conference Officer EMBL Heidelberg Germany Preliminary programme Are you on social media Post using EMBLNicESeq and don t forget to tag EMBLEvents The programme will be shared here in due time Some pre course work such as watching pre recordings and protocol reading with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 29 September 2025 DescriptionArrival at EMBL registrationWelcomeEMBL intro and house notes incl safety course overviewVladimir Benes EMBL Heidelberg GermanyBjoern Textor New England Biolabs USALaura Villacorta EMBL Heidelberg GermanyIcebreaking activityIntroduction round and Challenges and Expectations Coffee breakLecture Sequencing technology overview and how to work in a Core facilityVladimir BenesPractical session Cell fixation and preparation of DNA and RNATips Tricks with concurrent dinner Day 2 Tuesday 30 September 2025 DescriptionIntroduction Lecture NicE seq High Resolution Profiling of Accessible Chromatin of Formaldehyde fixed CellsChaithanya Ponnaluri Practical Session Cytosol ExtractionPractical Session NicE Seq labeling reactionLecture Methods for sequencing cell free DNA and cell free RNA from human plasmaChen SongLunchPractical Session DecrosslinkingPractical Session Clean UpPractical Session EndPrep Ligation Buffer ExchangePractical Session PCR ReactionLecture Streamlining processes of automated RNA library prepFerris Jung Practical Session Clean UpPractical Session Library QC QuantificationDinner Day 3 Wednesday 1 October 2025 DescriptionLecture Introduction into strand specific RNA Library Prep NicE Seq application in the field first hands on experiencesUlrike B nischPractical Session PolyA EnrichmentPractical Session FragmentationFirst Strand SynthesisSecond Strand SynthesisLunchPractical Session Clean UpPractical Session End prep of cDNA librariesPractical Session Adaptor LigationUSER TreatmentPractical Session PCR EnrichmentLecture NEBNext Product Development Streamlining workflows addressing new applicationsKeerthana KrishnanCoffee BreakPractical Session Clean UpPractical Session Library QC Qubit Bioanalyzer Dinner Day 4 Thursday 2 October 2025 TimeDescriptionLocation09 00 10 00Introduction Practical Session Set up of Sequencing runs of processed samplesTraining Labs10 00 10 45Lecture Epigenomic research Karin PrummelFlex Labs10 45 11 00Coffee BreakCourtyard Foyer11 00 12 00Practical Session Bioinformatics IIntroduction to data analysis and QC12 00 13 00LunchEMBL Canteen13 00 14 30Practical Session Bioinformatics IINicE seq examples and pitfalls14 30 16 00Final technical discussion roundFlex Labs16 00 16 45Feedback round and closing remarksFlex Labs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 x 1080 Social 1600 x 900 PPT Slide 16 9...

Vladimir Benes, Björn Textor

16 September - 19 September 2025

The human microbiome

Description OverviewSpeakersProgrammeEMBO trainingPractical informationNature Awards Lunch WorkshopsSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Human microbiota the collection of microbes living in and on our body have a significant impact on human health and well being They have been associated with numerous diseases yet we are still far from understanding their role in the context of life style and genetics Various initiatives are underway around the world to survey the human microbiota at several body sites characterize them understand their interactions with the human hosts elucidate their role in diseases and design possible therapeutic or dietary interventions Recent efforts have started mining the human microbiome data to discover bioactive compounds detect interactions between microbes and molecules and design novel interventions The return of this established meeting will bring together the community for a timely in person symposium picking up on developments across the field since the last edition in 2023 Session topics Methodological advances in microbiome analysis The human microbiome across biological age The human microbiome s response to nutrition and drugs Host microbe interactions Integrative approaches in microbiome research Microbiome targeted therapeutics Future outlook for microbiome research and translation What past participants say about the conference This conference provides an excellent opportunity to catch the latest trends in gut microbiome research It brought together a weighty number of important thought leaders and a fantastic forum for trailblazing research For anyone interested in gut microbiome I would unhesitatingly recommend the EMBL conference Ardhendu Chakrabortty Indian Institute of Technology Jodhpur India The presentations and discussions were very stimulating and gave useful insights into recent advances in human microbiome research The opportunity to engage in insightful discussions with fellow attendees and experts was invaluable Arunabh Sharma Kiel University Germany Speakers Speakers Emily Balskus Harvard University Howard Hughes Medical Institute USA Luis Pedro Coelho Queensland University of Technology Australia Francine Coelho Marques Monash University Australia Rochellys Diaz Heijtz Karolinska Institutet Sweden Francesca Gazzaniga Massachusetts General Hospital Harvard Medical School USA Lindsay Hall University of Birmingham UK Scott Hazelhurst University of the Witwatersrand South Africa Xiaofang Jiang National Institutes of Health USA Omry Koren Bar Ilan University Israel Tami Lieberman Massachusetts Institute of Technology USA Jeroen Raes KU Leuven Belgium Dennis Sandris Nielsen University of Copenhagen Denmark Melanie Schirmer Technische Universit t M nchen Germany Tim Spector King s College London UK Takuji Yamada Institute of Science Tokyo Japan Georg Zeller Leiden University Medical Center Germany Maria Zimmermann Kogadeeva EMBL Heidelberg Germany Scientific organisers Mani Arumugam University of Copenhagen Denmark Ami Bhatt Stanford University School of Medicine USA Peer Bork EMBL Heidelberg Germany Nicola Segata University of Trento Italy Conference organiser Luana Ribeiro EMBL Heidelberg Germany Programme Are you on social media Post using EESMicrobiome and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here Please find the bus schedule here Day 1 Tuesday 16 September 2025 Time Europe Berlin Speaker12 45 15 00Registration and light refreshments13 30 15 00The Global Grants for Gut Health Symposium The gut microbiome and long COVID13 30 14 00 Changes in the gut microbiome of children and young adults with long COVID and new therapeutic targets for the conditionSuchitra Hourigan National Institute of Allergy and Infectious Diseases National Institute of Health USA14 00 14 30 Could adding fermentable fibre to the diet help reduce the symptoms and impact of long COVID Paul Gill Monash University Australia14 30 15 00 Potential biomarkers for long COVID by screening for antibodies against hundreds of thousands of structures on gut microbesThomas Vogl Medical University of Vienna AustriaNot available on demand15 00 15 15Coffee break15 15 15 45Opening remarks and lightning talks by Scientific Organisers15 45 18 00Session 1 Microbiome dynamics and community assemblyChairs Lindsay Hall University of Birmingham UK Peer Bork EMBL Heidelberg Germany15 45 16 15Tradeoffs driving commensal survival and evolution within human microbiomesTami Lieberman Massachusetts Institute of Technology USA16 15 16 30Mapping the human gut microbiota s competitive cooperative web via high throughput interaction profilingJoshua Simcock Flanders Institute for Biotechnology VIB KU Leuven Belgium16 30 17 00Coffee break and Meet the speakers17 00 17 30Dynamics of the healthy gut microbiomeJeroen Raes KU Leuven Belgium17 30 17 45Microbial strain transmission between infants in nurseries drives gut microbiome developmentLiviana Ricci University of Trento Italy17 45 18 00Enterobacteriaceae synergize with food components to shape the competition between the dominant anaerobes of the human gutCaroline Taouk Helmholtz Center for Infection Research Germany18 00 18 45Poster sneak peek18 45 20 30Dinner in Canteen20 30 22 00After dinner drinks in the Foyer Day 2 Wednesday 17 September 2025 Time Europe Berlin Speaker09 00 12 00Session 2 Functional insights into microbial communitiesChairs Takuji Yamada Institute of Science Tokyo Japan Ami Bhatt Stanford University School of Medicine USA09 00 09 30Small proteins of the human microbiome and beyondLuis Pedro Coelho Queensland University of Technology Australia09 30 09 45From Metabolomics to Mechanism Hippurate Metabolism in the Vaginal Microbiota Augments Growth of Disease Associated BacteriaSeth Bloom Massachusetts General Hospital Harvard Medical School USA09 45 10 00Extensive diversity in Desulfovibrio species and microbial hydrogen sulfide production reveals disease associated gut microbiome signalsTingting Zheng Technical University of Munich Germany10 00 10 30Coffee break and Meet the speakers10 30 11 00Gut bacteria encoded reductase biotransform host derived metabolitesXiaofang Jiang National Institutes of Health USANot available on demand11 00 11 15Mapping microbial lipid production the impact of linoleic acid on gut microbiota composition and functionJosep Rubert Wageningen University The Netherlands11 15 11 45Oh no My gut microbiome got a virus infection The role of bacteriophages in the gut and their potential use for gut microbiome manipulationDennis Sandris Nielsen University of Copenhagen Denmark11 45 12 00A first glimpse into the molecular biology of obelisks Viroid like colonists of human microbiomesIvan Zheludev Gladstone Institute of Virology USA12 00 13 45Lunch and Meet the editors12 15 13 15Metabolon Workshop A Microbiome Toolkit for Multi Omics Discovery13 45 16 40Session 3 Early life microbiome development and impactChairs Tami Lieberman Massachusetts Institute of Technology USA Mani Arumugam University of Copenhagen Denmark13 45 14 15Exploring early life microbiome interactionsLindsay Hall University of Birmingham UK14 15 14 30Aggression a gut reaction The effects of the gut microbiome on aggressionSondra Turjeman Bar Ilan University Israel14 30 15 00Coffee break and Meet the speakers15 00 15 30The microbiome in the first 1000 days of lifeOmry Koren Bar Ilan University IsraelNot available on demand15 30 15 45Linking strain level genetic inference and development in the early life microbiomeTrine Zachariasen Copenhagen University Denmark15 45 16 00From mother to infant tracking the origin and development of the gut virome in the lifelines NEXT cohortAlexandra Zhernakova University Medical Center Groningen The Netherlands16 00 16 40Flash talk session 1 41 Oliver Aasmets 53 Adrian Barreno Sanchez 65 Rima Chakaroun 67 Kanta Chechi 69 Minghao Chia 85 Biswajit Dubashi 98 Gloria Fackelmann 99 Clarissa Febinia 119 Anna Ursula Happel 121 Vitor Heidrich 137 Shen Jin 183 Chiara Mazzoni 193 Suguru Nishijima 199 Kateryna Pantiukh 217 Claes Ohlsson 219 Renate Ruigrok 237 Trishla Sinha16 40 18 40Poster Session 1 odd numbers 18 40Free evening Day 3 Thursday 18 September 2025 Time Europe Berlin Speaker09 00 12 00Session 4 Microbiome host interactions in health and diseaseChairs Emily Balskus Harvard University USA Peer Bork EMBL Heidelberg Germany09 00 09 30Understanding gut to host communication to prevent cardiovascular diseaseFrancine Coelho Marques Monash University Australia09 30 09 45Microbiome signatures of virulence in the oral gut brain axis influence Parkinson s disease and cognitive decline pathophysiologyFrederick Clasen King s College London UK09 45 10 00The human gut archaeome an overlooked microbial domain with emerging links to colorectal cancerChristine Moissl Eichinger Medical University of Graz AustriaNot available on demand10 00 10 30Coffee break and Meet the speakers10 30 11 00Microbiota gut brain interactions exploring new mechanisms and therapeutics in neurodevelopmental disordersRochellys Diaz Heijtz Karolinska Institutet Sweden11 00 11 15Mechanisms of FMT efficacy in IBD beyond strain engraftmentPatrick Schimmel Medical University of Graz Austria11 15 11 45Overcoming microbiome dependent resistance to cancer immunotherapyFrancesca Gazzaniga Massachusetts General Hospital Harvard Medical School USA11 45 12 00Inadequate dietary fibre intake increases gut derived uremic toxins that contribute to hypertensionChudan Xu Monash University Australia12 00 13 30Lunch13 30 16 30Session 5 Human microbiome epidemiology and associationsChairs Ami Bhatt Stanford University School of Medicine USA Nicola Segata University of Trento Italy13 30 14 00Insights from large scale gut metagenomics and diet data the PREDICT studiesTim Spector King s College London UK14 00 14 15Gut microbes with the gbu genes determine TMAO production from L carnitine intake and serve as a biomarker for precision nutritionWei Kai Wu National Taiwan University Taiwan14 15 14 30Gut microbiome composition and future atherosclerotic cardiovascular diseaseKamalita Pertiwi Uppsala University Sweden14 30 15 00Coffee break and Meet the speakers15 00 15 30Expanding the human gut microbiome atlas of Africa opportunities and challengesScott Hazelhurst University of the Witwatersrand South AfricaNot available on demand15 30 15 45Glycan metabolism of the human gut microbiomeQuinten Ducarmon Leiden University Medical Center The Netherlands15 45 16 15Deep learning based discovery of narrow spectrum antibioticsTakuji Yamada Institute of Science Tokyo Japan16 15 16 30Baseline gut microbial profiles outperform human genetic and metabolic traits in classifying individualized blood pressure responses to antihypertensive agentsLianmin Chen Nanjing Medical University China Virtual 16 30 17 10Flash talk session 2 50 Gabriel Baldanzi 52 Veronika Kucharov Pettersen 70 Serena Sanna 64 Aurelie Cenier 78 Koen Dekkers 84 Anders Dohlman 116 Michaela Herz 126 Julien Tap 138 Yi Jin 160 Santosh Lamichhane 204 Niladri Pati 206 Gianmarco Piccinno 243 Nele Taba 253 Nienke van Beek 277 Li Fang Yeo17 10 19 10Poster Session 2 even numbers 19 10 21 10Conference Gala Dinner21 10 00 00Party with live band Day 4 Friday 19 September 2025 Time Europe Berlin Speaker09 00 12 30Session 6 Advances in microbiome analytical approachesChairs Luis Pedro Coelho Queensland University of Technology Australia Mani Arumugam University of Copenhagen Denmark09 00 09 30Gene centric metagenomic analyses reveal functional insights into diseaseMelanie Schirmer Technische Universit t M nchen GermanyNot available on demand09 30 09 45MetaPepticon automated anticancer peptide prediction from genomics and metagenomics datasetsMuzaffer Arikan Istanbul University Turkey09 45 10 15Gut and mucosal microbiome in colorectal cancerGeorg Zeller Leiden University Medical Center Germany10 15 10 45Coffee break and Meet the speakers10 45 11 00Uncovering the neuroactive landscape of the human gut microbiomeMireia Valles Colomer Pompeu Fabra University Spain11 00 11 15Structural biology aids interpretation of single nucleotide variants in human gut microbiomeArchontis Goumagias University Medical Center Groningen The Netherlands11 15 11 45Discovering metabolic gene functions in bacteria with multi omics approachesMaria Zimmermann Kogadeeva EMBL Heidelberg Germany11 45 12 00Integrated multi omics pipeline for biomarker discovery in acute on chronic liver failurePeter Treit Max Planck Institute of Biochemistry Germany12 00 12 30Deciphering the human microbiome with chemistryEmily Balskus Harvard University USA12 30 12 45Closing Remarks and Poster Prize Announcements12 45Packed lunch and departure13 15Bus to the airport13 30Bus to all stops downtown including ISG EMBO training EMBO training session How to write a scientific paper Overview This training module introduces the fundamental elements of publishing scientific research focusing on the structure and content of a manuscript how to assemble effective figures and how to write impactful titles and abstracts Led by an experienced EMBO Press scientific editor participants will explore the strategic planning for publication including determining authorship organising data and selecting the most appropriate journal for submission The session will run for 4 hours on the first morning of the symposium and will provide an engaging and interactive learning environment Date Tuesday 16 September 2025 Time 8 30 12 30 Europe Berlin It will include hands on exercises group work and lively discussions to help participants develop a practical understanding of how to write a successful scientific paper Audience This training session is designed for a maximum of 20 PhD students and postdocs who want to improve their scientific writing and publishing skills Learning outcomes At the end of the module participants will Understand the purpose and the structure of each section of a scientific paper title and abstract introduction results materials and methods discussion references and data availability Gain practical experience in assembling figures and writing titles and abstracts Receive guidance from instructors and peer feedback to refine the critical components of a successful scientific manuscript Registration For more information and to register please contact annika diederich embo org Registration deadline 9 September 2025 The training session is limited to 20 participants who will be selected on a first come first served basis Selected participants must commit to attending the entire module Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Luana Ribeiro for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact Luana Ribeiro for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 15 August 2025 in some cases at special rates Please email the hotel directly quoting the booking code EES25 08 to confirm the exact price of the room Hotel AnlageMeininger HeidelbergHotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg City ZentrumB B HotelHotel Vier Jahreszeiten HeidelbergStaycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergInterCity Hotel Heidelberg Travel information For travel information please see here Update below If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket The Event Ticket is currently not available We are awaiting details on new offers Please check back for more information or get in touch with us at events embl org For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Nature Awards Nature Awards Global Grants for Gut Health The gut microbiome and long COVIDTuesday 16th September 13 30 15 00Hosted by Nature Portfolio in partnership with Yakult this mini symposium will showcase research from international grantees exploring how gut microbiota may influence long COVID symptoms including gastrointestinal and neuropsychiatric outcomes Featuring talks on microbial dysbiosis in children dietary fibre interventions and novel biomarker discovery Click here to view the abstracts Global Grants for Gut Health abstracts Programme Time Europe Berlin TalkSpeaker13 30Welcome and Introductory RemarksAtin Sharma Assoc Editor Nature Microbiology13 35Persistent gut microbiome dysbiosis and elevated fecal biomarkers in children post SARS CoV 2 infection experiencing prolonged gastrointestinal and neuropsychiatric symptomsGrantee 1 Suchitra Hourigan National Institute of Allergy and Infectious Diseases National Institute of Health USASpeaker Mickayla Bacorn University of Maryland School of Medicinehttps www nature com articles d42473 024 00090 713 55 Q A Session14 00Investigating the immunomodulatory and clinical effects of using dietary fibre intervention to target the gut microbiota in patients with Long COVIDGrantee 2 Jane Varney Department of Immunology Monash University AustraliaSpeaker Paul Gill Department of Immunology Monash Universityhttps www nature com articles d42473 024 00091 614 20 Q A Session14 25Potential biomarkers for long COVID by screening for antibodies against hundreds of thousands of structures on gut microbes Grantee 3 Thomas Vogl Medical University of Vienna Austriahttps www nature com articles d42473 024 00092 514 45Q A Session14 50Closing RemarksAtin Sharma Assoc Editor Nature Microbiology About the Global Grants for Gut Health The Global Grants for Gut Health is a competitive grant programme for investigator initiated research into the human gut microbiota supported by Yakult and Nature Research The scope of the programme varies each year and considers proposals for one year research projects that advance understanding of the impact of the gut microbiota on human health Judging panel Karen Scott Rowett institute University of Aberdeen UK Chair Ami S BhattStanford Medical School USA Deputy Chair Kiyoshi Takeda iFReC The University of Osaka JapanSarah Le Beer University of Antwerp Belgium Gabriel Vinderola National University of the Littoral ArgentineZigui ChenChinese University of Hong Kong China Lunch Workshops For on site participants only This industry webinar will be hosted by our sponsor Metabolon during the EMBO EMBL Symposium The Human Microbiome on Wednesday 17 September 2025 12 15 13 15 Participation in this workshop is free of charge for registered on site conference attendees ABSTRACT Integrating and Visualizing Multiomics Microbiome Datasets with Metabolon s Microbiome Research Solution Meaningful discovery happens when quality data careful interpretation and intuitive technology come together to reveal clear insights from complexity With a single sample submission Metabolon s Microbiome Research Solution can provide metagenomics untargeted metabolomics and absolute quantification of short chain fatty acids This comprehensive but flexible approach empowers users to tailor omics analyses to specific research objectives Upon completion of sample analysis users gain access to Metabolon s Microbiome Tool for intuitive data exploration and interpretation Built around the trusted Integrated Bioinformatics Platform IBP the Microbiome Tool unifies metagenomic metabolomic and phenotypic data within a code less accessible platform that simplifies complex analyses without compromising flexibility or analytical depth and rigor From raw sequencing data to rich visualizations the platform performs end to end processing without requiring manual intervention or custom engineering Rather than focusing solely on taxonomic profiling or single omics correlations this solution seamlessly connects microbial composition to functional metabolic activity With this foundation in place researchers are equipped from the outset to identify the microbes that differentiate sample groups uncover community level patterns and investigate functional variation across taxonomic levels with confidence and ease Whether the goal is mechanistic discovery or translational application Metabolon s Microbiome Tool offers the analytical power and user friendly experience needed to translate microbiome data into actionable knowledge In this workshop a Metabolon scientist will walk you through the platform and showcase real world case studies What you ll learn Microbiome Research Solution Overview How to configure and create metabolomic and metagenomic datasets into a single harmonized project Metagenomics and Metabolomics Complementarity What combining these two omic modalities can achieve Microbiome Analysis Tool Demonstration of interactive QC taxonomic profiling clustering and correlation analysis and rich visualizations inside IBP Integrative Multiomics Using machine learning to link microbial taxa with metabolite profiles for predictive modelling Biological Interpretation Service How expert curated reports distil complex results into clear narratives and next step hypotheses Sponsors Silver Sponsor Bronze Sponsor Event Sponsors Don Whitley Scientific Singer Instruments Event supporter Media partners ChemBioChem a Wiley journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Molecular Medicine an EMBO Press journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information Request a sponsorship brochure If you are interested in becoming a media partner of this event please visit our media partnerships webpage Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Mani Arumugam, Ami Bhatt, Peer Bork, Nicola Segata

14 September - 19 September 2025

Advanced methods in bioimage analysis

Description OverviewTrainers speakers staffProgrammePractical informationSponsorsMedia kit Overview This course will take place at EMBL Heidelberg with the option to attend virtually Course overview Bioimage analysis has become a keystone of biological research the deluge of data produced by increasingly advanced microscopes calls for experts able to guide life scientists in the methods and software to be used to produce quantitative knowledge from this data Due to the complexity of the data without such expert guidance it is very likely that image analysis algorithms may be applied incorrectly possibly even producing erroneous results Moreover the diversity of imaging modalities analysis algorithms and software solutions is growing so rapidly that even experts are overwhelmed This advanced course concentrates on teaching cutting edge concepts and tools for quantitative image analysis and will seek to upgrade the competencies of future bioimage analysis experts on both theoretical algorithm advancements as well as on practical implementation skills Audience This course is aimed at early career scientists and staff scientists working in microscopy or image analysis facilities who already have experience in bioimage analysis Moreover participants should already provide or show a clear intent of providing bioimage analysis support to other researchers with less or no experience in bioimage analysis In selecting participants we look for scientific excellence immediate application of the methods learned motivation to disseminate and networking skills We expect a solid background in bioimage analysis and at least basic programming skills Modules resources Image analysis workflow and data management Using AI and natural language processing for image analysis Cells and particles tracking Spatial statistics and omics integration Deep learning for bioimage analysis Image based behaviour modeling Spatial modeling and shape analysis Open science reproducible research and women in science Learning outcomes For each module participants will learn both theoretical and practical aspects of the latest developments in the fields of bioimage analysis concepts and tools After this course participants are expected to be able to confidently operate and interface with a representative selection of open and closed source image analysis software Participants should be able to apply what they have learnt to their own image data as well as to image data of their colleagues What past participants say about the course The EMBL practical course on Advanced Methods in Bioimage Analysis represents a turning point in my career As a Ph D student having the opportunity to meet network and learn with the most experienced researchers in this topic changed how I analyze my images and speed up my image analysis workflows Fernanda Garcia Fossa Institute of Biology University of Campinas This event has been granted the following EMBO sustainability badge Grade 3 of 3 Trainers speakers staff Speakers trainer and staff Philippe Andrey INRAE Versailles France Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Fynn Beuttenm ller EMBL Heidelberg Germany Beth Cimini Broad Institute USA Robert Haase University of Leipzig Germany Wangjun Hu Heidelberg University Germany Anna Klemm Scilifelab Uppsala University Sweden Nikolai K hler Heidelberg University Germany Anna Kreshuk EMBL Heidelberg Germany Matthew McCormick fideus labs USA Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University France Norman Rzepka scalable minds Germany Suganya Sivagurunathan Scilifelab Uppsala University Sweden Jean Yves Tinevez Institut Pasteur France Pavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany Christian Tischer EMBL Heidelberg Germany Britta Velten Heidelberg University Germany Carolina W hlby Scilifelab Uppsala University Sweden Virginie Uhlmann University of Z rich Switzerland Kevin Yamauchi ETH Z rich Switzerland Scientific organisers Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Anna Klemm Scilifelab Uppsala University Sweden Perrine Paul Gilloteaux University of Nantes France Christian Tischer EMBL Heidelberg Germany Course organisers Julia Patricia Nohle Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Senior Scientific Training and Digital Learning Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBOBioImage and don t forget to tag EMBLEvents Please note Some pre course work such as watching pre recordings and protocol reading with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 0 Onboarding Monday 08 September 2025 Time Europe Berlin SessionLocation14 00 15 00Virtual Onboarding Testrun Zoom testingPre course material material on eCampusOnline Day 1 Sunday 14 September 2025 Time Europe Berlin SessionLocation12 45 13 00Bus from ISG to EMBLISG Hotel13 00 13 30WelcomeWelcome to EMBL House notes safety and course overviewCourtyard Room A B13 30 15 00Networking part 1 Virtual poster sessionGroup sessionsCourtyard Room A B15 00 15 30Coffee breakCourtyard Room A B15 30 17 00Networking part 2 Virtual poster sessionFlash talksCourtyard Room A B17 00 18 00Treasure hunt onsite participants only Courtyard Room A B18 00 19 00DinnerEMBL Canteen19 00 20 00Networking part 3 Virtual poster sessionATC Rooftop Lounge20 00Bus from EMBL to ISG Hotel Day 2 Monday 15 September 2025 Time Europe Berlin SessionLocation08 40 09 00Transport from ISG to EMBL09 00 10 45Overview of the day 5 min Practical session 1 Image Analysis workflow and data managementIncluding Q A on pre recorded lectureVirginie Uhlman University of Z rich Switzerland Assisted by Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University France Christian Tischer EMBL Heidelberg GermanyComputer Training Lab10 45 11 15Coffee break and meet the trainersOutside CTL11 15 13 00Practical session 1 Image Analysis workflow and data management continued Including Q A on pre recorded lecture Virginie Uhlman University of Z rich Switzerland Assisted by Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University France Christian Tischer EMBL Heidelberg GermanyComputer Training Lab13 00 14 00Lunch short walk in the forest optional EMBL Canteen14 00 14 30Lecture 1 Women in sciencePerrine Paul Gilloteaux CNRS UAR BioCore Nantes University France14 30 16 15Practical session 2 Using AI and natural language processing to help image analysisIncluding Q A on pre recorded lecture breaks as needed Led by Robert Haase University of Leipzig Germany Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Christian Tischer EMBL Heidelberg GermanyComputer Training Lab16 15 16 45Coffee break and meet the trainersOutside CTL16 45 18 30Practical session 2 Using AI and natural language processing to help image analysis continued with debrief Led by Robert Haase University of Leipzig Germany Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Christian Tischer EMBL Heidelberg GermanyComputer Training Lab18 30 20 15Pizza Dinner Onsite NetworkingATC Rooftop Lounge20 15Bus from EMBL to ISG Day 3 Tuesday 16 September 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG to EMBL Heidelberg08 55 09 00Overview of the dayCourtyard Room A B09 00 10 45Practical session 3 TrackingIncluding Q A on pre recorded lecture Led by Jean Yves Tinevez Institut Pasteur France Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University FranceComputer Training Lab10 45 11 15Coffee breakOutside CTL11 15 13 00Practical session 3 Tracking continued Including Q A on pre recorded lecture Led by Jean Yves Tinevez Institut Pasteur France Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University FranceComputer Training Lab13 00 14 00Lunch short walk in the forest optional EMBL Canteen14 00 15 30Practical session 4 Behavior Modeling Led by Kevin Yamauchi Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University FranceComputer Training Lab15 30 16 00Coffee break and meet the speakerOutside CTL16 00 16 15Course group photoOutside ATC16 00 18 00Practical session 4 Behavior Modeling continued with debrief Led by Kevin Yamauchi Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University FranceComputer Training Lab18 00 18 30Lecture 2 Research Integrity virtual talk Beth Cimini Broad Institute USACourtyard Room A B18 30 20 15Tapas Dinner Onsite NetworkingRooftop Lounge20 15Bus from EMBL to ISG Day 4 Wednesday 17 September 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG to EMBL Heidelberg08 55 09 00Overview of the dayCourtyard Room A B09 00 10 45Practical session 5 Spatial statistics and omics integrationIncluding Q A on pre recorded lecture Led by Britta Velten Heidelberg University Germany Assisted by Anna Klemm Scilifelab Uppsala University Sweden Nikolai K hler and Wangjun Hu Heidelberg University GermanyComputer Training Lab10 45 11 15Coffee break and meet the speakerOutside CTL11 15 13 00Practical session 5 Spatial statistics and omics integration continued Including Q A on pre recorded lecture Led by Britta Velten Heidelberg University Germany Assisted by Anna Klemm Scilifelab Uppsala University Sweden Nikolai K hler and Wangjun Hu Heidelberg University GermanyComputer Training Lab13 00 14 00LunchEMBL Canteen14 00 15 00Keynote lecture Image based exploration of molecular and morphological components of tissueCarolina W hlby Uppsala University SwedenCourtyard Room A B15 00 16 45Round Table discussion Led by Anna Klemm and Suganya Sivagurunathan Scilifelab Uppsala University SwedenCourtyard Room A B16 45 17 00Transport from EMBL to ISGEMBL19 00 19 15Bus from ISG downtownISG19 15 21 30Downtown Heidelberg course dinnerat Oskar Vinothek RestaurantDowntown Day 5 Thursday 18 September 2025 Time Europe Berlin SessionLocation08 40 09 00Bus from ISG to EMBL Heidelberg09 00 10 00Lecture 4 Introduction to working with OME Zarr Tutorial Christian Tischer EMBL Heidelberg GermanyJosh Moore German BioImaging GermanyComputer Training Lab10 00 11 00Lecture 5 Software presentation and key challenge subsequent Q ANorman Rzepka scalable minds GermanyCourtyard Room A B11 00 12 00Lecture 6 Open science and bioimage analysis virtual Pavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics GermanyCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Lecture 7 Software presentation and key challenge subsequent Q A virtual Matthew McCormick fideus labs USACourtyard Room A B14 00 15 45Software Practical Work on your own data with Software representativesComputer Training Lab15 45 16 15Coffee break and meet the speakersOutside CTL16 15 18 00Software Practical Work on your own data with Software representativesComputer Training Lab18 00Bus from EMBL to ISGATC Entrance18 30 21 00BBQ and networking at ISG HotelISG Hotel Day 6 Friday 19 September 2025 Time Europe Berlin SessionLocation08 45 09 00Bus from ISG to EMBL Heidelberg09 00 10 45Practical session 6 AI for Life SciencesIncluding Q A on pre recorded lectureLed by Fynn Beuttenm ller EMBL Heidelberg Germany Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Anna Klemm Scilifelab Uppsala University SwedenComputer Training Lab10 45 11 15Coffee break and meet the trainersOutside CTL11 15 13 00Practical session 6 AI for Life Sciences continued Including Q A on pre recorded lecture Led by Fynn Beuttenm ller EMBL Heidelberg Germany Assisted by Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Anna Klemm Scilifelab Uppsala University Sweden Computer Training Lab13 00 14 00Lunch short walk in the forest optional EMBL Canteen14 00 15 45Practical session 7 Statistical spatial analysis and modeling with BIP Including Q A on pre recorded lecture Led by Philippe Andrey INRAE Versailles France Assisted by Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University France Christian Tischer EMBL Heidelberg GermanyComputer Training Lab15 45 16 00Coffee break and meet the trainersOutside CTL16 00 17 45Practical session 7 continued Statistical spatial analysis and modeling with BIP Including Q A on pre recorded lecture Led by Philippe Andrey INRAE Versailles France Assisted by Perrine Paul Gilloteaux CNRS UAR BioCore Nantes University France Christian Tischer EMBL Heidelberg GermanyComputer Training Lab17 45 18 00Wrap up Course debrief by organizers with discussionCourtyard Room A B18 00Bus downtown and to train station Practical information Registration fees and motivation letter The course is limited to 20 onsite and 6 virtual participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1100Virtual Academia PhD 190Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation will be booked for the selected participants at the ISG Hotel for the default dates of 13 to 19 6 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 22 50 per night availability of single rooms may be limited This should be paid by you directly to the ISG Hotel during your stay We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course You will need admin rights to be able to install the software on your computer and we recommend you try this before the course If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Virtual participation guidelines Guidelines Do not broadcast the course to unregistered participants Do not share your login details with others You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in eCampus for you to enjoy during the event How to ask questions Questions during and after the talks can be asked in the live streaming platform If time runs out or you think of a question later you can use the EMBL eCampus forum or send a direct message to the speaker trainer Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated As many virtual participants are attending from around the world we do our best to accommodate as many time zones as possible when creating the programme Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Event sponsors Media partners Microcscopy and Analysis a Wiley journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Ignacio Arganda-Carreras, Anna Klemm, Perrine Paul-Gilloteaux, Christian Tischer

14 September - 19 September 2025

Methods for infectious disease modelling using genomics

Description This EMBO Practical course will introduce concepts methods and tools for carrying out infectious disease modelling as well as for developing models further by leveraging the power of genomics Modelling infectious diseases can help to understand the mechanisms of pathogen evolution and predict the development of epidemics This had an immense impact on the COVID 19 pandemic and is crucial for the general surveillance of pathogens In this course participants will learn about compartmental models such as Susceptible Infectious Recovered SIR models how to adapt them to a pathogen of their interest and the differences between stochastic and deterministic models Taking this further participants will apply these models to epidemic settings in order to predict changes in case numbers and disease severity Additionally the participants will learn how to implement and adapt genomics informed models for pathogen evolution and they will learn how to make use of genomics to create timed phylogenies and reconstruct ancestral states Finally bringing together transmission modelling and genomic data participants will learn about phylodynamic models and how this can help to detect changes in case numbers and pathogenicity earlier and more reliably than with transmission models alone...

Barbara Etzi

9 September - 12 September 2025

Developmental metabolism: flows of energy, matter, and information

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The fundamental question of the role of metabolism in development has seen a revival in interest over recent years creating the need for the first edition of this workshop in 2023 This second edition is set to reunite the community two years on and to ensure the ongoing interactions that can propel progress in developmental metabolism In this rapidly advancing field metabolomic methods play a crucial role in unraveling complex processes The workshop will again aim to bring together researchers from diverse backgrounds developmental biology genetics epigenetics ecology physics and math to provide the developmental metabolism community with cutting edge research and methodologies applied across scales insights into the latest advancements in metabolomic techniques and their application to developmental biology New for 2025 will be an increased integration of tool development and technologies and an added focus on novel metabolomic approaches Topics over the six sessions will include Physical bioenergetics Metabolic constraints in developing systems Metabolic control who got the power Metabolic signaling in time and space metabolites as morphogens New enabling technologies to study metabolism in time and space Metabolic plasticity facing ever changing internal and external environments This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Asaph Aharoni Weizmann Institute of Science Israel Aydan Bulut Karslioglu Max Planck Institute of Molecular Cell Biology and Genetics Germany Clotilde Cadart Institut Cochin France Margarete Diaz Cuadros Harvard Medical School USA Aissam Ikmi EMBL Heidelberg Germany Heidi Lempradl Van Andel Institute USA Heidi McBride McGill University Canada Shyh Chang Ng Chinese Academy of Sciences China Jun Park University of California Los Angeles USA Markus Ralser Charit Universit tsmedizin Berlin Germany Teresa Rayon Babraham Insitute UK Matthew Regan University of Montreal Canada Remote Berna Sozen Yale School of Medicine USA Marion Walhout UMass Chan Medical School USA Remote Jan Zylicz University of Copenhagen Denmark Scientific organisers Alexander Aulehla EMBL Heidelberg Germany Heather Christofk University of California Los Angeles USA Heidi Lempradl Van Andel Institute USA Jonathan Rodenfels Max Planck Institute of Molecular Cell Biology and Genetics Germany Conference organiser Nathalie Sneider EMBL Heidelberg Germany Programme Are you on social media Post using EMBODevMet and don t forget to tag EMBLEvents For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please note that the programme is subject to change Some speakers may need to join virtually to give their talk The poster listing is available here The bus schedule for this conference is available here Day 1 Tuesday 9 September 2025 Time Europe Berlin Speaker12 15 13 45Registration and light refreshmentskindly sponsored by Van Adel Institute13 45 13 55Opening remarks by organisers13 55 16 10Session 1 Chair Heidi Lempradl Van Andel Institute USA13 55 14 25Functional organization and evolution of metabolism Markus Ralser Charit Universit tsmedizin Berlin Germany14 25 14 40The role of metabolism during hydra tissue patterning and regenerationMaryl ne Bonvin Friedrich Miescher Institute for Biomedical Research FMI Switzerland14 40 15 10TCA cycle rewiring underpins early developmentJan Zylicz Novo Nordisk Foundation Center for Stem Cell Medicine University of Copenhagen University of Copenhagen Denmark15 10 15 40Coffee Break and Meet the speakers Markus Ralser Jan Zylicz 15 40 15 55Compartmentalisation of metabolism in somatic cells sustains germ cell survival through lactate shuttling in the Drosophila testisMarc Amoyel Umiversity College London UK15 55 16 10Dissecting Growth and Energy Scaling in Drosophila Using Integrated Imaging and Metabolic ProfilingYoumna Atieh Institut de Biologie du D veloppement de Marseille IBDM France16 10 17 10Breakout session 1Discussion within individual discussion groups16 10 16 25 Scientific organisers meeting with group facilitators participants to make their way to the section of the Helix reserved for their group 16 25 17 10 Group discussion17 10 17 40Flash talk session 1 odd numbers 3 minutes each 1 slide 35 Christopher Bell 37 James Cleland 39 Gillian Davidson 41 Bianca Habermann 45 Roksolana Kobylinska 49 Manohara Mahadeva 51 Liliana Pi eros 55 Bhabesh Tripathy17 40 19 10Poster session 1 odd numbers19 10 20 10Dinner in Canteen20 10 22 00Welcome reception in ATC Rooftop lounge Day 2 Wednesday 10 September 2025 Time Europe Berlin Speaker09 00 12 00Session 2Chair Jonathan Rodenfels Max Planck Institute of Molecular Cell Biology and GeneticsGermany09 00 09 30Exploring the role of protein metabolism in developmental tempo Teresa Rayon Babraham Institute UKNot available on demand09 30 09 45The role of nucleotide biosynthesis regulation in neuromuscular developmentJustin Kollman University of Washington USA09 45 10 00A comparative analysis of the energetics of early development across animal phylaVinca Yadav Max Planck Institute of Molecular Cell Biology and Genetics Germany10 00 10 30Metabolic regulation of early embryogenesis integrating patterning and timingAydan Bulut Karslioglu Max Planck Institute for Molecular Genetics GermanyNot available on demand10 30 11 00Coffee Break and Meet the speakersThere will be a conference group photo at the start of the coffee break at 10 3011 00 11 30Selective utilization of glucose metabolism guides mammalian gastrulationBerna Sozen Yale School of Medicine USANot available on demand11 30 11 45Decoding meiotic metabolism divergent energy pathways and nucleotide synthesis in spermatogenic cellsNina Mayorek The Hebrew University of Jerusalem Israel11 45 12 00Metabolic rewiring drives tolerance to oncogenic mutations in skin stem cellsAnupama Hemalatha Friedrich Meischer Institute for Biomedical Sciences SwitzerlandNot available on demand12 00 13 30Lunch and Meet the Editors from 13 00 13 30 withInes Alvarez Garcia PLOS BiologySalvatore Fabbiano Cell PressIeva Gailite EMBO Press13 30 15 00Session 3Chair Berna Sozen Yale School of Medicine USA13 30 14 00Genome scale models of metabolic wiring and rewiringMarian Walhout University of Massachusetts Chan Medical School USA Remote speaker 14 00 14 15Thermal constraints on the mitochondrial proteome refine the hot mitochondria hypothesisPablo Rivera Mej as EMBL Heidelberg Germany14 15 14 45Metabolic profiling flux thermodynamics control and beyondJun Park University of California Los Angeles USA14 45 15 15Coffee Break and Meet the speakers Teresa Rayon Berna Sozen Jun Park 15 15 16 15Breakout session 2Discussion within individual discussion groups16 15 16 45Flash talk session 2 even numbers 3 minutes each 1 slide 36 Johann Sora Blakytny 38 Gloria Brea Calvo 40 Jaroslav Ferenc 42 Mona Hosny 44 Shuzo Kato 48 Junjie Lui 50 Hidenobu Miyazawa 52 Kathrin Schmeisser 54 Mariano Stornaiuolo 56 Yu Wei16 45 18 15Poster session 2 even numbers18 15 19 45Dinner in Canteen19 45 22 00All posters viewing and drinks Day 3 Thursday 11 September 2025 Time Europe Berlin Speaker09 00 12 00Session 4Chair Jan Zylicz University of Copenhagen Denmark09 00 09 30Spatial metabolomics of skeletal muscle regenerationShyh Chang Ng Chinese Academy of Sciences China09 30 09 45Metabolic control of cell fate specification and morphogenesis in a mammalian embryo modelAlba Villaronga Luque MPI CBG Germany09 45 10 00Developmental programs of nutrient acquisition influence oncogenic competence in YAP driven liver cancerMikaela Wong Peter MacCallum Cancer Centre Australia10 00 10 30Mitochondria derived vesicles connect mitochondria tolysosomes at the nexus of immune signaling and celldeathHeidi McBride McGill University Canada10 30 11 00Coffee Break and Meet the speakers Shyh Chang Ng Heidi McBride 11 00 11 30The sea anemone dilemma to grow or not to grow tentacles Aissam Ikmi EMBL Heidelberg GermanyNot available on demand11 30 11 45TCA cycle rewiring underpins implantation and histone acetylation programmingEleni Kafkia Novo Nordisk Foundation Center for Stem Cell Medicine University of Copenhagen Denmark11 45 12 00Membrane potential as an overarching controller of somitogenisis in chick embryo from metabolism to biomechanics and signal transductionMagdalena Kowacz Institute of Animal Reproduction and Food Research Polish Academy of Sciences Poland12 00 13 30Lunch13 30 16 15Session 5 Chair Heather Christofk University of California Los AngelesUSA13 30 14 00Whole embryo energy expenditure varies cell size across Xenopus species Clotilde Cadart Institut Cochin FranceNot available on demand14 00 14 15Nature as a great sculptor a lesson from ferroptotic trigger wavesSheng S H Chen Academia Sinica Taiwan14 15 14 30Development dependent mitochondrial stress response activation in the heartMilica Popovic Uniklinik K ln Germany14 30 15 00Gut microbial contributions to hibernation metabolismMatthew Regan University of Montreal Canada Remote speaker 15 00 15 30Coffee Break and Meet the speakers Aissam Ikmi Clotilde Cadart 15 30 16 00A gas and brake mechanism in the plant growth defense tradeoffAsaph Aharoni Weizmann Institute of Science Israel16 00 16 15The energetic cost for molecular synchronization theoretical insights from cyanobacterial circadian clockDongliang Zhang Max Planck Institut f r Physik komplexer Systeme Germany16 15 17 15Breakout session 3Discussion within individual discussion groups17 15 17 45Coffee break17 45 18 45Breakout sessions discussion summary auditorium 18 45 20 45Conference dinner in Canteen20 45 23 00Conference party with live music from the Popcakes Day 4 Friday 12 September 2025 09 30 12 00Session 6 Chair Alexander Aulehla EMBL Heidelberg Germany09 30 10 00Regulation of species specific developmental rates by redox metabolismMargarete Diaz Cuadros Massachusetts General Hospital Harvard Medical School USA10 00 10 30Glycolytic activity instructs germ layer proportions through regulation of Nodal and Wnt signallingKristina Sukanya Stapornwongkul Institute of Molecular Biotechnology Austria10 30 10 45From dormancy to new life metabolic activation of the embryoChristoph G belein Whitehead Institute Massachusetts Institute of Technology United States of America10 45 11 15Coffee Break and Meet the speakers Asaph Aharoni Margarete Diaz Cuadros 11 15 11 30Fuelling fate lineage specific metabolic remodelling directs cell fate decisions during early human developmentMirjam Verbeek The Francis Crick Institute UKNot available on demand11 30 12 00The kynurenine pathway a metabolic link between maternal obesity and offspring phenotypeHeidi Lempradl Van Andel Institute USA12 00 12 15Closing Remarks and poster prize announcements12 15 12 45Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 550On site PhD Student 385On site Industry 770On site Journal Editors 300Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Nathalie Sneider for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Friday 8 August 2025 in some cases at special rates Please email the hotel directly quoting the booking code DMB25 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityB B HotelISG Hotel Staycity Aparthotel HeidelbergExzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus schedule is available here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page Sponsors Event sponsor Van Andel Institute Media partners Ageing and Cancer Research Treatment ACRT a Science Exploration Press journal ChemBioChem a Wiley journal Development The Company of Biologists journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal The EMBO Journal an EMBO Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Alexander Aulehla, Heather Christofk, Heidi Lempradl, Jonathan Rodenfels

5 September 2025

ChEMBL workshop for drug design

Description ChEMBL is a database of bioactivity for drugs and drug like compounds This webinar provides an overview of the chemical biology resources at EMBL EBI focusing on the ChEMBL database In the first part the webinar describes the structure of ChEMBL how data is integrated and curated and how you can access the information within ChEMBL In the second part some worked examples based on drug discovery scenarios have been illustrated Each worked example will be accompanied by guidance and a demonstration showing how the ChEMBL interface can be used to extract relevant information for drug discovery initiatives...

3 September - 7 September 2025

Protein synthesis and translational control

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Mechanisms that shape cellular proteomes are critical for life This conference focuses on the process of protein synthesis from the molecular and structural understanding of the translational machinery to its regulation its implications in cell and organismal biology and its alteration in disease The regulation of mRNA translation is critical to maintaining cell homeostasis and mediates cellular responses to environmental physiological and pathological cues Given the central importance of protein synthesis it is unsurprising that dysregulation or defects in mRNA translation are widely linked to disease including cancer neurological or metabolic disorders and viral infection In recent years technical advances have challenged hitherto established dogmas uncovered new quality control mechanisms expanded the breadth of translation regulators enhanced our understanding of the dynamics of translation in living cells and revealed unexpected interconnections with other cellular processes such as metabolism Advances in these aspects of mRNA translation will be featured as well as new insights into translation regulation in physiology and disease Session topics Initiation Ribosome elongation and termination Emerging technologies and methods Turnover and quality control Pathogens and diseases Translation regulation What past participants say about the conference This conference is one of the must attend conferences The atmosphere is very lively lots of good discussions The whole conference is superbly organised I look forward to attending the next time this meeting takes place Tiina Tamm University of Tartu Estonia Absolutely loved everything about the conference from the guest speakers and topics covered to the food and organization of the events I could tell serious detailed planning had gone into the event with a nice flow throughout the week Jin Yeong Kim Georgia College State University USA Speakers Keynote speakers Reuven Agami Netherlands Cancer Institute The Netherlands Lori Passmore MRC Laboratory of Molecular Biology UK Marina Rodnina Max Planck Institute for Multidisciplinary Studies Germany Speakers and session chairs Gloria Brar University of California Berkeley USA Martin Bushell CRUK Scotland Institute UK Faraz Mardakheh University of Oxford UK Oliver M hlemann University of Bern Switzerland Joanna Rorbach Karolinska Institute Sweden Noam Stern Ginossar Weizmann Institute of Science Israel Additional speakers will be selected from abstracts Scientific organisers Alfredo Castello University of Glasgow UK Christopher Fraser University of California Davis USA F tima Gebauer Centre for Genomic Regulation CRG The Barcelona Institute of Science and Technology BIST University of Pompeu Fabra UPF Spain Christian Spahn Charit Universit tsmedizin Berlin Germany Conference organiser Sophie Dutzi EMBL Heidelberg Germany Chris Stocks EMBL Heidelberg Germany Programme Are you on social media Post using EMBLProtein and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here Please find the conference bus schedule here Day 1 Wednesday 3 September Time Europe CET Speaker16 00 18 00Arrival and Registration with light refreshments18 00 18 15Welcome remarks by the scientific organisers18 15 19 00Keynote lectureMolecular insights into the mRNA poly A tail machineryLori Passmore MRC Laboratory of Molecular Biology UK19 00 19 45Keynote lectureGenetic drivers of amino acid Substitutants in cancerReuven Agami The Netherlands Cancer Institute The Netherlands19 45 20 15Coffee break20 15 21 00Keynote lectureAmbiguities in translation from decoding to protein foldingMarina Rodnina Max Planck Institute for Multidisciplinary Studies GermanyNot available on demand21 00 22 30Welcome reception with light refreshments Day 2 Thursday 4 September Time Europe CET Speaker08 30 9 00Arrival and coffee09 00 14 15Session 1 Ribosome elongation and terminationChair Joanna Rorbach Karolinska Institute Sweden09 00 09 10Introduction overviewChair Joanna Rorbach Karolinska Institute Sweden09 10 09 30Ribosome pausing and surveillance pathways in mitochondrial protein synthesisJoanna Rorbach Karolinska Institute Sweden09 30 09 45Translation initiation factor eIF3m regulates ubiquitination dependent early elongation pausing of ribosomesSonja Reitter Mannheim Institute for Innate Immunoscience MI3 and Mannheim Cancer Center MCC Medical Faculty Mannheim Heidelberg University Germany09 45 10 00Structural insights into the role of eIF3 in translation mediated by the HCV IRESTakuhiro Ito RIKEN Japan10 00 10 15CryoET visualisation of mRNA translation dynamics in mammalian cellsJuliette Fedry MRC Laboratory of Molecular Biology UKNot available on demand10 15 10 30Old but full of surprises structural and mechanistic insights into the ribosome dependent function of the ancient translational ATPase YchF Ola1Hans Joachim Wieden University of Manitoba CanadaNot available on demand10 30 11 00Coffee break11 00 11 15Girolline as a probe into eIF5A functionTilman Schneider Poetsch RIKEN Japan11 15 11 30Mitoxantrone is a potent translation inhibitor that binds within the ribosomal exit tunnel and induces ribosome rich stress granule formationWitold Szaflarski Poznan University of Medical Sciences Poland11 30 11 45Context specific ribosome protection by macrolide resistance ABCF proteinsMaxim Svetlov University of Illinois Chicago United States of America11 45 12 00Molecular architecture and diversity of StopGo 2A translational recodingPhilipp Zuber MRC Laboratory of Molecular Biology United Kingdom12 00 12 15The final cut how release factors drive peptidyl tRNA hydrolysis on the ribosomeYury Polikanov University of Illinois Chicago United States of America12 15 12 30Coupling translation to membrane insertion of mitochondrial encoded proteinsNiels Fischer Max Planck Institute for Multidisciplinary Sciences GermanyNot available on demand12 30 12 45NAA40 and NAC cooperate in co translational histone acetylation in humansDandan Guan Ludwig Maximilians University of Munich Germany12 45 14 15Lunch in ATC Foyer and meet the editors14 15 17 45Session 2 Quality controlChair Oliver M hlemann University of Bern Switzerland14 15 14 25Introduction overview from session chairChair Oliver M hlemann University of Bern Switzerland14 25 14 45Deciphering the role of the deubiquitinase USP9X in ribosome associated quality controlOliver M hlemann University of Bern SwitzerlandNot available on demand14 45 15 00A novel quality control pathway on the ribosome dedicated for co translational protein complex assemblyAyala Shiber Technion Israel Institute of Technology IsraelNot available on demand15 00 15 15Coordination of protein synthesis and decay in mammalian cellsDavid Suter EPFL Switzerland15 15 15 30uL24 UFMylation cycle orchestrates quality control and recycling of 60S ribosomal subunits at the ERFrancesco Scavone Stanford University United States of America15 30 15 45RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress responseJacqueline Cordes Ludwig Maximilians University of Munich Germany15 45 16 15Coffee break Meet the speakers of Day 1 and Day 216 15 16 30P site tRNA mediated mRNA decay a co translational mechanism linking codon usage to gene expression controlJan Erzberger University of Texas Southwestern Medical Center United States of America16 30 16 45Jlp2 is an RQC complex independent release factor that protects cells during translation elongation stressKaushik Iyer Johannes Gutenberg University Germany16 45 17 00Mapping the ubiquitin code of translation a translatome wide blueprint for co translational quality controlMaximilian Seidel EMBL Heidelberg GermanyNot available on demand17 00 17 15ZAK activation at the collided ribosomeVienna Huso John Hopkins School of Medicine17 15 17 30 ZAK is a sensor of mRNA stasis at the ribosomal exit channelZhenzhen Wu University of Copenhagen Denmark17 30 17 45Structural insight into how Gcn20 drives Gcn1 recruitment to disomesHelge Paternoga University of Hamburg Germany17 45 18 00Pre dinner drinks18 00 19 30Dinner19 30 21 30Poster session 1 ODD numbers in ATC HelicesPlease find the poster listing here 21 30 22 30Wine Cheese in ATC Foyer Day 3 Friday 5 September Time Europe CET Speaker08 30 9 00Arrival and coffee09 00 12 00Session 3 InitiationChair Martin Bushell CRUK Scotland Institute UK09 00 09 10Introduction overview from session chairChair Martin Bushell CRUK Scotland Institute UK09 10 09 30The role of DDX6 in co translational assemble of protein complexesMartin Bushell University of Glasgow UK09 30 09 45Dissecting the function of key eukaryotic translation factors by rapid degradation and multiomic approachesChiara Giacomelli Max Delbr ck Center for Molecular Medicine Germany09 45 10 00mRNA specific translation initiation rates direct protein fate and prevent cellular stressKyrillos Abdallah Yale University USA10 00 10 15Accurate high throughput quantitation of cap dependent and IRES translation from human and viral mRNAs using IRES TrAPPrJoel McManus Carnegie Mellon University United States of America10 15 10 30Decoding the sequence requirements for translation initiationBram Verhagen Oncode Institute Hubrecht Institute KNAW UMC Utrecht The NetherlandsNot available on demand10 30 11 00Coffee break11 00 11 15Structural and molecular insights into specialized translation driven by the ribosome mRNA binding channelDavide Fraticelli Weizmann Institute of Science Israel11 15 11 30mTOR controls ternary complex free 43S ribosome loading onto mRNAsRamona Weber University of Zurich Switzerland11 30 11 45Molecular mechanistic insights into Non AUG codon stringencyXimena Zottig University of Massachusetts Chan Medical School USA11 45 12 00Structural basis for repeat associated non AUG RAN translation initiation on C9orf72 mRNA in ALS FTDJay Brito Querido University of Michigan United States of AmericaNot available on demand12 00 16 00Free time Sightseeing16 00 19 00Session 4 Pathogens and diseasesChair Noam Stern Ginossar Weizmann Institute of Science Israel16 00 16 10Introduction overview from session chairChair Noam Stern Ginossar Weizmann Institute of Science Israel16 10 16 30eN1 Methylpseudouridine Directly Modulates Translation DynamicschairNoam Stern Ginossar Weizmann Institute of Science Israel16 30 16 45A dynamic ribosome interactome landscape during Sindbis virus infection reveals novel virus host interactionsEmiliano Ricci National Institute for Health and Medical Research INSERM France16 45 17 00Translational control at high resolution role of rRNA modifications in Staphylococcus aureusRoberto Bahena CERBM GIE France17 00 17 15Lifecycle of ribosome hibernation factorsSergey Melnikov Newcastle University United Kingdom17 15 17 30Selective silencing of antibiotic tethered ribosomes as a resistance mechanism against aminoglycosidesIngo Wohlgemuth Max Planck Institute for Multidisciplinary Sciences GermanyNot available on demand17 30 18 00Coffee break18 00 18 15eEF2K deletion increases immunosurveillance in luminal bladder cancerJennifer Waters Fred Hutchinson Cancer Center United States of America18 15 18 30The translational repressor Eif4a2 promotes extracellular matrix deposition to accelerate hepatocellular carcinoma initiationPauline Herviou CRUK Scotland Institute United Kingdom18 30 18 45CYFIP1 inspired peptidomimetic disrupts cap dependent Translation a game changer in cancer and fragile X syndrome therapyAlice Romagnoli Polytechnic University of Marche Italy18 45 19 00Targeting dipeptide repeat protein synthesis rescues C9ORF72 linked ALS FTD phenotypesPaulo J Da Costa Institut de Biologie Moleculaire et Cellulaire IBMC CNRS University of Strasbourg France19 00 19 15Pre dinner drinks19 15 20 30Dinner20 30 22 30Poster session 2 EVEN numbers in ATC HelicesPlease find the poster listing here Day 4 Saturday 6 September Time Europe CET Speaker08 30 09 00Arrival and coffee09 00 12 45Session 5 Translation regulationChair Gloria Brar University of California Berkeley USA09 00 09 10Introduction overview from session chairChair Gloria Brar University of California Berkeley USA09 10 09 30A small disordered region of Ded1 controls the cellular response to heat independent of stress granule formationGloria Brar University of California Berkeley USANot available on demand09 30 09 45Newly synthesised mRNA selectively escapes translational repression following acute stressMostafa Zedan ETH Z rich SwitzerlandNot available on demand09 45 10 00From nucleus to cytoplasm a histone chaperone shapes stress induced translationMartin M ller Ludwig Maximilians University of Munich Germany10 00 10 15Dynamics of environmental stress dictate alternative ribosome preservation strategies in bacterial dormancySophie Kopetschke Heidelberg University Germany10 15 10 30How fungal ribosomes hibernate during cellular stressSimone Mattei EMBL Heidelberg GermanyNot available on demand10 30 10 45Deciphering regulation and functional conservation of dormant ribosomesJosef Roehsner Research Institute of Molecular Pathology IMP Austria10 45 11 00Codon dependent regulation of mRNA translation and stability by ZC3H7A and ZC3H7B RNA binding proteinsSeyed Mehdi Jafarnejad Queen s University Belfast United Kingdom11 00 11 30Coffee break11 30 11 45Di codon organization orchestrates the malignant proteomeKiana Hosseinpour Moghaddam Karolinska Institutet SwedenNot available on demandVirtual talk11 45 12 00A mitogen activated translational checkpoint via eIF6 phosphorylationAlessandra Scagliola National Institute of Molecular Genetics University Milan ItalyNot available on demand12 00 12 15Rare poly A binding protein family member PABPC5 supports melanoma progression via selective translational activation of membrane associated mRNAsLorenza Pedalino Centre for Genomic Regulation CRG SpainNot available on demand12 15 12 30Beyond RNA binding protein protein interactions sustain RBP function in translational regulationBrian Carrick MRC Laboratory of Molecular Biology United Kingdom12 30 12 45RNA linked CRISPR screening reveals regulatory networks for translational control in human cellsArvind Subramaniam Fred Hutchinson Cancer Center United States of America12 45 14 00Lunch14 00 16 00Poster session 3 ALL numbers in ATC HelicesPlease find the poster listing here 16 00 18 30Session 6 Emerging technologies and methodsChair Faraz Mardakheh University of Oxford UK16 00 16 10Introduction overview from session chairChair Faraz Mardakheh University of Oxford UK16 10 16 30TREX a method for identification of region specific protein interactors of RNA in living cellsFaraz Mardakheh University of Oxford UK16 30 16 45A versatile toolbox to determine IRES activity in cells and embryonic tissuesKathrin Leppek University Hospital Bonn University of Bonn Germany16 45 17 00Gaining structural information for dozens of RBP ribosome interactions and how they change upon stress via SPIDRLena Street Columbia University United States of America17 00 17 15Elusive translational events and translon regulatory complexity revealed with massive aggregation of ribosome profiling dataMichal Swirski University of Warsaw Poland17 15 17 45Coffee Break Meet the speakers of Day 3 and Day 417 45 18 00Comprehensive visualization of actively translating polysomes by cryo EMYollete Guillen Schlippe Charit Universit tsmedizin Berlin GermanyNot available on demand18 00 18 15RiboNano tRNAseq reveals stress induced remodeling of ribosome bound tRNAsMie Monti Centre for Genomic Regulation CRG SpainNot available on demand18 15 18 30Use of RAPPL ribosome isolation for functional and structural studies of translationSergej Djuranovic Brown University Germany18 30 18 45Closing remarks and poster prize announcements18 45 21 00Conference Dinner21 00 23 59Conference Party Day 5 Sunday 7 September Departure day Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 800On site PhD Student 700On site Industry 1000On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Sophie Dutzi for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 02 August 2025 in some cases at special rates Please email the hotel directly quoting the booking code TRC25 01 to confirm the exact price of the room Hotel AnlageHotel Holl nder Hof Hotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg CityB B HotelISG Hotel Staycity Aparthotel HeidelbergExzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger HeidelbergHotel Vier Jahreszeiten Heidelberg Travel information For travel information please see here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event supporter Media partners Advanced Biology a Wiley journal Advanced Genetics a Wiley journal BioEssays a Wiley journal ChemBioChem a Wiley journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Journal of Cell Science The Company of Biologists journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Synthetic Biology and Engineering a SCIEPublish Journal The EMBO Journal an EMBO Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Alfredo Castello, Christopher Fraser, Fatima Gebauer, Christian Spahn

31 August - 5 September 2025

FISHing for RNAs: classical to single molecule approaches

Description OverviewSpeakerProgrammePractical informationSponsorsMedia kit Overview Course overview Tight spatio temporal regulation of the number and localisation of RNA molecules is key to ensuring precise control of gene expression State of the art in situ hybridisation ISH technologies enable visualisation and quantification of RNA molecules in a biological context from organism and tissue to cell Moreover with sequential ISH technologies e g MER FISH the RNA signature of individual cells or even their sub compartments can be identified and characterised in situ This course targeting early stage scientists PhD students and postdocs will highlight three powerful RNA visualisation techniques in histological and whole tissue samples During this course the participants will visualise subcellular localisation of selected transcripts through conventional ISH and more sensitive quantitative and resolutive smFISH single molecule fluorescent ISH and HCR ISH hybridisation chain reaction based RNA ISH hybridisation methods Additionally the participants will learn to design and produce their own FISH probes cost efficiently Particular emphasis will be placed on biodata image processing and quantitative analysis The well balanced programme covers hands on wet and dry lab practicals technological limitations troubleshooting and good practices networking and career opportunities as well as lectures from leaders in the field Elevate your research and benefit from our excellent trainer to participant ratio for personalised training in addition to world class research facilities and networking opportunities with leading experts What past participants say about the course Extremely happy after attending EMBOFISHingRNAs course Was an amazing experience to meet and learn from such good trainers and speakers and to connect with other participants working in RNA biology on different topics Florencia Cabrera Tallinn University of Technology Estonia The FISHing for RNA course led by passionate and expert instructors provided a well structured curriculum and abundant resources to enhance my understanding of ISH techniques I now feel confident in applying these techniques to my own research Celeste Marin Duke University USA This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speaker Speakers trainers and staff Edouard Bertrand Institute of Human Genetics France Florence Besse Institut de Biologie Valrose France Mainak Bose Indian Institute of Technology Kharagpur India Chiara Capponi University of Rome La Sapienza Italy Marina Chekulaeva Max Delbr ck Center for Molecular Medicine Germany Sara Di Persio M nster University Hospital Germany Nadia Formicola CBI Toulouse France Imre Gaspar Turbine ai Hungary Helena Jambor University of Applied Sciences of the Grisons Switzerland Emerald Perlas EMBL Rome Italy Eve Seuntjens KU Leuven Belgium Evelina Tutucci Vrije Universiteit Amsterdam The Netherlands Franka Voigt University of Zurich Switzerland Elisabeth Zielonka EMBL Heidelberg Germany Scientific organisers Florence Besse Institut de Biologie Valrose France Imre Gaspar Turbine ai Hungary Emerald Perlas EMBL Rome Italy Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Michelle Steinhauer Scientific Training Officer EMBL Heidelberg Germany Karo Wolkersdorfer Course and Conference Officer EMBL Heidelberg Germany Ad la Graf Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOFISHingRNAs and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Some pre course work such as watching pre recordings protocol reading and computational exercises with an estimated time of 13 hours will be required and will be shared in advance of the course Day 0 Tuesday 29 July 2025 Time Europe Berlin SpeakerLocation13 30 15 00Familiarise with EMBL eCampus platform and prime on pre course work exercises and learning materialsGet access to pre course materialPre course material Pre recorded lecture 1 by Emerald Perlas on Histology overview and applications Pre recorded lecture 2 by Florence Besse on Subcellular localization of mRNAs in neuronal memory circuits Pre recorded lecture 3 by Imre Gaspar on RNA detection methodsVideo and study material related to practical sessions Practical 1 Conventional ISH 2 5 hours Practical 2 Probe design 3 hours Practical 3 smFISH and HCR ISH 2 5 hours Practical 5 Image analysis 3 hoursOnline on EMBL eCampus Day 1 Sunday 31 August 2025 Time Europe Berlin SessionLocation13 00 13 30Welcome coffeeISG Hotel13 30 14 00Welcome house notes and course overviewISG Hotel14 00 15 30Ice breaker Flash talks and activity in groups ISG Hotel15 30 16 15Keynote lecture SmFISH in low and high throughput unravels gene expression mechanismsEdouard Bertrand Institute of Human Genetics FranceISG Hotel16 15 17 00Discussion Session Pre recorded talk on Histology overview and applicationsEmerald Perlas EMBL Rome ItalyISG Hotel17 00 17 30Coffee breakISG Hotel17 30 18 15Discussion session Pre recorded talk on Subcellular localization of mRNAs in neuronal memory circuits Florence Besse Institut de Biologie Valrose FranceISG Hotel18 15 19 00Discussion session Pre recorded talk on RNA detection methodsImre Gaspar Turbine ai HungaryISG Hotel19 00 20 30DinnerISG Hotel Day 2 Monday 1 September 2025 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel bus stop09 00 09 10Overview of the dayImre Gaspar Turbine ai HungaryCourtyard Room A B09 10 09 30Lab safety instructionsCourtyard Room A B09 30 10 00Practical Probe design and productionTheory and demo of probe designImre Gaspar Turbine ai HungaryTraining Lab A B10 00 10 45Practical Theory and demo of smFISH and HCR ISHImre Gaspar Turbine ai HungaryNadia Formicola CBI Toulouse FranceTraining Lab A B10 45 11 00Coffee breakTraining Lab A B11 00 11 45Practical Probe design and production continued Probe preparation ddUTP dye conjugation Imre Gaspar Turbine ai HungaryTraining Lab A B11 45 12 30Keynote lecture RNA regulation in neurons and neurodegenerationMarina Chekulaeva Max Delbr ck Center for Molecular MedicineGermanyCourtyard Room A B12 30 13 30Lunch breakEMBL canteen13 30 14 15Practical Conventional ISHIntroduction and theory of conventional ISHEmerald Perlas EMBL Rome ItalyChiara Capponi University of Rome La Sapienza ItalySara Di Persio M nster University Hospital GermanyTraining Lab A B14 15 16 15Practical Conventional ISH continued section pre treatment Proteinase K digest acetylation hybridization set up Emerald Perlas EMBL Rome ItalyChiara Capponi University of Rome La Sapienza ItalySara Di Persio M nster University Hospital Germanywith flexible coffee breakTraining Lab A B16 15 16 45Practical smFISH HCR ISH3a sm FISH Probe labeling set upImre Gaspar Turbine ai HungaryFlorence Besse Institut de Biologie Valrose FranceNadia Formicola CBI Toulouse FranceTraining Lab A B16 45 17 00Coffee breakATC Rooftop lounge17 00 18 30Student presentationsATC Rooftop lounge18 30 20 00Dinner with discussion on career topicsATC Rooftop lounge20 00Bus to HotelEMBL bus stop Day 3 Tuesday 2 September 2025 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel bus stop08 50 09 00Overview of the dayEmerald Perlas EMBL Rome ItalyCourtyard Room A B09 00 10 00Practical Conventional ISH continued Post hybridisation washesEmerald Perlas EMBL Rome ItalyChiara Capponi University of Rome La Sapienza ItalySara Di Persio M nster University Hospital GermanyTraining Lab A B10 00 10 45Keynote lecture in vivo imaging of RNA biogenesisFranka Voigt Universit t Z rich SwitzerlandCourtyard Room A B10 45 11 00Coffee breakCourtyard Room A B11 00 12 00Practical Conventional ISH continued Staining set upEmerald Perlas EMBL Rome ItalyChiara Capponi University of Rome La Sapienza ItalySara Di Persio M nster University Hospital GermanyTraining Lab A B12 00 13 00Lunch with discussion on next career stepsEMBL canteen13 00 15 15Practical smFISH HCR ISH continued 3a and b sm FISH probe purification and QC and HCR ISH specimen pre work and hybridization setupImre Gaspar Turbine ai HungaryFlorence Besse Institut de Biologie Valrose FranceNadia Formicola CBI Toulouse FranceTraining Lab A B15 15 16 15Practical Conventional ISH continued Washing and mounting of specimenEmerald Perlas EMBL Rome ItalyChiara Capponi University of Rome La Sapienza ItalySara Di Persio M nster University Hospital GermanyTraining Lab A B16 15 17 00Keynote lecture GE regulation in microbesEvelina Tutucci Vrije Universiteit Amsterdam The NetherlandsCourtyard Room A B17 00 17 30Coffee breakATC Rooftop lounge17 30 19 00Student presentationsATC Rooftop lounge19 00 20 00DinnerATC Rooftop lounge20 00Bus to HotelEMBL bus stop Day 4 Wednesday 3 September Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel bus stop08 50 09 00Overview of the dayFlorence Besse Institut de Biologie Valrose FranceCourtyard Room A B09 00 11 15Practical smFISH HCR ISH continued 3a and 3b HCR ISH washessmFISH pre hybridisation set up for incubationHCR ISH Amplification set up for reactionsmFISH hybridisationImre Gaspar Turbine ai HungaryFlorence Besse Institut de Biologie Valrose FranceNadia Formicolar CBI Toulouse Francewith concurrent coffee breakTraining Lab A B11 15 12 00Keynote lecture Data presentation data integrityHelena Jambor University of Applied Sciences of the Grisons SwitzerlandCourtyard Room A B12 00 12 10Group photoCourtyard Room A B12 10 13 00Lunch breakEMBL canteen13 00 15 30Practical Conventional ISH continued Conventional ISH imagingEmerald Perlas EMBL Rome ItalyChiara Capponi University of Rome La Sapienza ItalySara Di Persio M nster University Hospital GermanyWith concurrent coffee breakTraining Lab A B15 30 15 45Coffee breakCourtyard Room A B15 45 16 30Keynote lecture 3D Insights into Octopus Arm Development via Hybridization Chain ReactionEve Seuntjens KU Leuven BelgiumCourtyard Room A B16 30 18 00Practical smFISH HCR ISH continued 3a and 3b smFISH HCR ISH washes and specimen mountingImre Gaspar Turbine ai HungaryFlorence Besse Institut de Biologie Valrose FranceNadia Formicolar CBI Toulouse FranceWith concurrent coffee breakTraining Lab A B18 00 19 00DinnerEMBL canteen19 00 20 00Discussion on responsible conduct of research Experimental design and Standards and controls in the ISH fieldModerator Helena Jambor University of Applied Sciences of the Grisons SwitzerlandCourtyard Room A B20 00Bus to HotelEMBL bus stop Day 5 Thursday 4 September Time Europe Berlin SessionLocation08 30Bus Hoffmann from hotel to EMBL ATC EntranceISG Hotel bus stop08 50 09 00Overview of the dayCourtyard Room A B09 00 10 30Practical Imaging in groups smFISH and HCR ISH Imre Gaspar Turbine ai HungaryFlorence Besse Institut de Biologie Valrose FranceNadia Formicolar CBI Toulouse FranceIn parallel Discussion Meet the speaker in groupsSpeakers onsite Guided tour of The World of Molecular Biology Imaging Centre EMBLALMF andCourtyard Room A B10 30 10 45Coffee breakCourtyard Room A B10 45 12 15Practical Imaging in groups smFISH and HCR ISH continuedImre Gaspar Turbine ai HungaryFlorence Besse Institut de Biologie Valrose FranceNadia Formicolar CBI Toulouse FranceDiscussion Meet the speaker in groupsSpeakers onsite Guided tour of The World of Molecular Biology Imaging Centre EMBLALMF andCourtyard Room A B12 15 13 15LunchEMBL canteen13 15 14 00Keynote lecture RNA protein phase condensatesMainak Bose Indian Institute of Technology Kharagpur IndiaCourtyard Room A B14 00 16 00Practical ISH image analysisBasics ISH image processing and analysis part 1Imre Gaspar Turbine ai HungaryComputer Training Lab16 00 17 30Discussion session Trouble shootingCourtyard Room A B17 30 18 00Bus to downtown HeidelbergEMBL bus stop18 00 19 30Heidelberg Guided City TourHeidelberg old town19 30 22 00Downtown DinnerOskar Restaurant and Vinotheque Day 6 Friday 5 September Time Europe Berlin SessionLocation08 30 08 50Bus Hoffmann from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Overview of the dayElisabeth Zielonka EMBL Heidelberg GermanyComputer Training Lab09 00 10 15Practical ISH image analysisBasics ISH image processing and analysis part 2Imre Gaspar Turbine ai HungaryComputer Training Lab10 15 10 30Coffee breakComputer Training Lab10 30 12 00Practical ISH image analysisBasics ISH image processing and analysis part 3Imre Gaspar Turbine ai HungaryComputer Training Lab12 00 13 00LunchEMBL canteen13 00 15 30Group work Participants preparing group presentationssupported by trainers with concurrent coffee breakCourtyard Room A B15 30 16 30Discussion Group Data Presentations incl Discussions with concurrent coffee breakCourtyard Room A B16 30 17 00Wrap upFlorence Besse Institut de Biologie Valrose FranceCourtyard Room A B17 00 18 00Bus to ISG hotel and Heidelberg train stationEMBL bus stop19 00 20 00Dinner Flammkuchen ISG Hotel Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation will be booked for the selected participants at the ISG Hotel for the default dates of Sunday 31 August until Saturday 6 September 6 nights In case you would like to have a single room please let the hotel know You will be required to pay an additional cost of 22 50 per night availability of single rooms may be limited This should be paid by you directly to the ISG Hotel during your stay We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here Update below If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket The Event Ticket is currently not available We are awaiting details on new offers Please check back for more information or get in touch with us at events embl org For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Event partner Event sponsor Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1350 Social 1600 900 PPT Slide 16 9...

Florence Besse, Imre Gaspar, Emerald Perlas, Elisabeth Zielonka

3 August - 8 August 2025

Drosophila genetics and genomics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Drosophila as a model system has remained a powerful driver of biological research for over a century Emergence of techniques like CRISPR Cas9 next generation sequencing single molecule sm FISH and single cell genomics have dramatically expanded the toolkit available for research in Drosophila These techniques are now routinely applied to answer important knowledge gaps in developmental biology cell biology physiology neurobiology genome regulation evolution behavior and population genetics This course will cover the latest advances in this direction through a combination of lectures delivered by world renowned experts and hands on practical sessions on the above topics delivered by excellent trainers to help the participants rapidly absorb knowledge towards application for their own research This course will play a key role in fostering the next generation of Drosophila biologists through transfer of this knowledge built up for over a century opportunities for excellent networking and developing collaborations and long term relationships We have incorporated new speakers trainers and refreshed the content where relevant to remain up to date Based on the overwhelmingly positive feedback received from the 2023 course which was 3 fold oversubscribed we believe there is a strong argument to repeat this course to serve the large community of Drosophila biologists Audience The course is aimed at PhD students and early stage postdoctoral researchers who want to start using or enhance their knowledge of Drosophila as a model organism Modules The power of Drosophila as a model organism Discerning function through genetic perturbation Revealing new insights through live imaging New views from single cell genomics Drosophila diversity and evolution Organismal interactions Learning outcomes Training session will familiarize attendees with classical and modern approaches to fruit fly genetics and genomics including genetic screens CRISPR Cas9 gene editing cutting edge imaging methods single cell analyses behavioral assays and learning from wild caught species What past participants say about this course The best course I have attended in a beautiful place and with people who are really interested in teaching speaking and helping to train us In addition the program was complete and covered all the existing techniques from the most traditional to the newest The topics covered are exciting And besides we spent a wonderful week with laughter delicious food and long evenings Genoveva Guerrero Centro Andaluz de Biolog a del Desarrollo Spain Great course I enjoyed every bit of it The course offered detailed insights into the field of Drosophila genetics with hands on practicals that help to bring the theory and practice into a broader picture so that we can start right away by incorporating new ideas into our own research I also enjoyed the networking opportunity to connect with the current and future top notch scientists of the Drosophila community Hannah Dickm nken Stein Aerts lab Belgium This event has been granted the following EMBO sustainability badge Grade 3 of 3 Speakers Speakers and trainers Noa Borst EMBL Heidelberg Germany Sarah Bray University of Cambridge United Kingdom Yutao Cao Friedrich Miescher Laboratory Germany Justin Crocker EMBL Heidelberg Germany Lautaro Gandara EMBL Heidelberg Germany Eileen Furlong EMBL Heidelberg Germany Yad Ghavi Helm Institute of Functional Genomics of Lyon France Nicolas Gompel University of Bonn Germany Jun Ishigohoka Friedrich Miescher Laboratory Germany Karla Kaun Brown University USA Nikos Konstantinides Institut Jacques Monod France Xinyi Li University of Bonn Germany Natalia Misunou EMBL Heidelberg Germany Lukas Neukomm University of Lausanne Switzerland Kate O Connor Giles Brown University USA Mireia Osuna Lopez EMBL Heidelberg Germany Luisa Pallares Friedrich Miescher Laboratory Germany Blanca Pijuan Sala EMBL Heidelberg Germany Ella Preger Ben Noon Technion Israel Institute of Technology Israel Andreas Prokop University of Manchester United Kingdom Gilles Storelli University of Cologne COS Heidelberg Germany Pavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany virtual speaker Dietrich Walsh EMBL Heidelberg Germany Scientific organisers Justin Crocker EMBL Heidelberg Germany Kate O Connor Giles Brown University USA Ella Preger Ben Noon Technion Israel Institute of Technology Israel Andreas Prokop University of Manchester United Kingdom Course organisers Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBODrosophila and don t forget to tag EMBLEvents Some pre course work with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change For registered participants recorded talks will be accessible on demand unless indicated otherwise Day 1 Sunday 3 August 2025 Time Europe Berlin SessionLocation13 30 13 40Bus from hotel to EMBL ATC EntranceISG Hotel13 40 14 15Registration and light refreshmentsCourtyard Room A B14 15 14 40Welcome and house notes and course overviewCourtyard Room A B14 40 14 45Overview of the dayThe power of Drosophila as a model organism Andreas ProkopCourtyard Room A B14 45 15 45Ice breaking activity Flash talksCourtyard Room A B15 45 16 00Coffee Break16 00 17 00Lecture The power of Drosophila as a model and how to advocate itAndreas Prokop University of Manchester United KingdomCourtyard Room A B17 00 18 00Treasure huntATC18 00 19 30Practical 1 Drosophila anatomy development genetics and outreach advocacyJustin Crocker EMBL Heidelberg GermanyKate O Connor Giles Brown University USAElla Preger Ben Noon Technion Israel Institute of Technology IsraelAndreas Prokop University of Manchester United KingdomTraining Lab A B19 30 19 45Bus to HotelEMBL Bus Stop19 45 21 45Dinner and NetworkingISG Hotel Day 2 Monday 4 August 2025 Time Europe Berlin SessionLocation08 35 08 50Bus from hotel to EMBL ATC Entrance08 50 09 00Overview of the dayDiscerning function through genetic perturbation Kate O Connor GilesCourtyard Room A B09 00 09 20Lab safety instructionsEllen Malovrh EMBL Heidelberg GermanyCourtyard Room A B09 20 10 20Lecture Screen design in fliesLukas Neukomm University of Lausanne SwitzerlandCourtyard Room A B10 20 10 30Group photoTBC10 30 11 00Coffee break and meet the speakers11 00 12 00Lecture Fly behavioural screensKarla Kaun Brown University USACourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Lecture CRISPR design and screens in fliesKate O Connor Giles Brown University USACourtyard Room A B14 00 15 00Practical 2 Applied CRISPR design in fliesNoa Borst EMBL Heidelberg GermanyKate O Connor Giles Brown University USAElla Preger Ben Noon Technion Israel Institute of Technology IsraelAndreas Prokop University of Manchester United KingdomComputer Training Lab15 00 15 30Coffee break and meet the speakers15 30 17 15Practical 2 Applied CRISPR design in flies continued Noa Borst EMBL Heidelberg GermanyKate O Connor Giles Brown University USAElla Preger Ben Noon Technion Israel Institute of Technology IsraelAndreas Prokop University of Manchester United KingdomComputer Training Lab17 15 17 45Poster session 1 flash talksCourtyard Room A B17 45 19 45Poster session 1Helix A19 45 20 30Vegetarian dinnerEMBL Canteen20 30 20 45Bus to HotelEMBL Bus Stop Day 3 Tuesday 5 August 2025 Time Europe Berlin SessionLocation08 35 08 50Bus from hotel to EMBL ATC Entrance08 50 09 00Overview of the dayRevealing new insights through live imaging Justin CrockerCourtyard Room A B09 00 10 00Lecture Imaging across scalesPavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany virtual speaker Courtyard Room A B10 00 10 30Coffee break and meet the speakers10 30 11 30Lecture Quantitative imaging of transcriptionSarah Bray University of Cambridge United KingdomCourtyard Room A B11 30 12 30Introduction to live imaging in the fly and usage of FAIR principles in data processing and storageJustin Crocker EMBL Heidelberg GermanyPavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany virtual speaker Courtyard Room A B12 30 13 30LunchEMBL Canteen13 30 15 30Practical 3 Live imaging in the flyNoa Borst EMBL Heidelberg GermanyJustin Crocker EMBL Heidelberg GermanyLautaro Gandara EMBL Heidelberg GermanyNatalia Misunou EMBL Heidelberg GermanyDietrich Walsh EMBL Heidelberg and EMBL Imaging Centre GermanyTraining Lab A B Imaging Centre15 30 16 00Coffee break and meet the speakers16 00 17 30Practical 3 Live imaging in the fly continued Noa Borst EMBL Heidelberg GermanyJustin Crocker EMBL Heidelberg GermanyLautaro Gandara EMBL Heidelberg GermanyNatalia Misunou EMBL Heidelberg GermanyDietrich Walsh EMBL Heidelberg and EMBL Imaging Centre GermanyImaging Centre17 30 18 00Poster session 2 flash talksCourtyard Room A B18 00 18 45Pizza dinnerATC Rooftop Lounge18 45 20 45Poster session 2Helix A20 45 21 00Bus to HotelEMBL Bus Stop Day 4 Wednesday 6 August 2025 Time Europe Berlin SessionLocation08 35 08 50Bus from hotel to EMBL ATC Entrance08 50 09 00Overview of the dayNew views from single cell genomics Ella Preger Ben NoonCourtyard Room A B09 00 10 00Lecture Systems biology of neural tissue differentiationNikos Konstantinides institut Jacques Monod FranceCourtyard Room A B10 00 10 30Coffee break and meet the speakers10 30 11 30Lecture Three dimensional organization of the genomeYad Ghavi Helm Institut de G nomique Fonctionnelle de Lyon FranceCourtyard Room A B11 30 12 30Lecture Genome regulation during developmental transitionsEileen Furlong EMBL Heidelberg GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 15 30Practical 4 Genomics at single cell resolutionYad Ghavi Helm Institut de G nomique Fonctionnelle de Lyon FranceNikos Konstantinides institut Jacques Monod FranceXinyi Li University of Bonn GermanyMireia Osuna Lopez EMBL Heidelberg GermanyElla Preger Ben Noon Technion Israel Institute of Technology IsraelTraining Lab A B15 30 16 00Coffee break and meet the speakers16 00 18 00Practical 4 Genomics at single cell resolution continued Yad Ghavi Helm Institut de G nomique Fonctionnelle de Lyon FranceNikos Konstantinides institut Jacques Monod FranceBlanca Pijuan Sala EMBL Heidelberg GermanyElla Preger Ben Noon Technion Israel Institute of Technology IsraelXinyi Li University of Bonn GermanyComputer Training Lab18 00 19 00Career Chat with trainers speakers and organisersATC Rooftop Lounge19 00 20 00DinnerEMBL Canteen20 00 20 15Bus to HotelEMBL Bus Stop Day 5 Thursday 7 August 2025 Time Europe Berlin SessionLocation08 35 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Overview of the dayDrosophila diversity and evolution Ella Preger Ben NoonCourtyard Room A B09 00 10 00Lecture The genetic basis of complex traitsLuisa Pallares Friedrich Miescher Lab GermanyCourtyard Room A B10 00 10 30Coffee break and meet the speakers10 30 11 30Lecture Genetics of phenotype evolutionNicolas Gompel University of Bonn GermanyCourtyard Room A B11 30 12 30Lecture How to build a research program lessons from the evolution of male genitalia in Drosophila Ella Preger Ben Noon Technion Israel Institute of Technology IsraelCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 15 30Practical 5 Drosophila speciation and behavioral analysisYutao Cao Friedrich Miescher Lab GermanyNicolas Gompel University of Bonn GermanyJun Ishigohoka Friedrich Miescher Lab GermanyXinyi Li University of Bonn GermanyLuisa Pallares Friedrich Miescher Lab GermanyTraining Lab A B15 30 15 45Coffee break and meet the speakers15 45 17 45Practical 5 Drosophila speciation and behavioral analysis continued Yutao Cao Friedrich Miescher Lab GermanyNicolas Gompel University of Bonn GermanyJun Ishigohoka Friedrich Miescher Lab GermanyXinyi Li University of Bonn GermanyLuisa Pallares Friedrich Miescher Lab GermanyTraining Lab A B17 45 18 45Lecture Understanding systems in context Fruit flies toxins and synthetic evolutionJustin Crocker EMBL Heidelberg GermanyCourtyard Room A B18 45 19 30Bus to downtown stop at ISG HotelEMBL Bus Stop19 30 21 30Downtown dinnerFlammkuchenhof Heidelberg Day 6 Friday 8 August 2025 Time Europe Berlin SessionLocation08 35 08 50Bus from hotel to EMBL ATC Entrance08 50 09 00Overview of the dayOrganismal interactions Andreas ProkopCourtyard Room A B09 00 10 00Lecture Gut microbes and metabolismGilles Storelli University of Cologne COS HeidelbergCourtyard Room A B10 00 10 30Coffee break and meet the speakers10 30 12 00Practical 6 Analysis of feeding choice and microbiome studies in DrosophilaReza Azanchi Brown University USARute Fernandes Discover Echo GermanyKarla Kaun Brown University USAGilles Storelli University of Cologne COS HeidelbergTraining Lab A B12 00 13 00LunchEMBL Canteen13 00 14 30Practical 6 Analysis of feeding choice and microbiome studies in Drosophila continued Reza Azanchi Brown University USARute Fernandes Discover Echo GermanyKarla Kaun Brown University USAGilles Storelli University of Cologne COS HeidelbergTraining Lab A B14 30 15 15Course feedback round and debriefCourtyard Room A B15 15 15 45Bus to Hotel and Heidelberg main stationEMBL Bus Stop Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 550PhD Student 550Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel The registration fee includes accommodation in twin rooms with breakfast Accommodation will be booked for the selected participants at the ISG Hotel for the default dates of 3 to 8 August 5 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 22 50 per night availability of single rooms may be limited This should be paid by you directly to the Hotel during your stay We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Course partners Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsoring embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Justin Crocker, Kate O’Connor-Giles, Ella Preger-Ben Noon, Andreas Prokop

30 July 2025

Deploying Nextflow pipelines in the cloud: a practical introduction

Description Modern biological research generates vast amounts of data that require complex computational workflows to process efficiently and reproducibly As data volumes continue to grow so does the demand for computing infrastructure to process them Deploying these workflows in the cloud is becoming increasingly common This webinar will introduce the fundamental concepts of cloud deployment for Nextflow pipelines and demonstrate the steps required for setting up a fully functional pipeline in the cloud We will begin by describing the purpose of Workflow Management Systems such as Nextflow and why they have become indispensable in modern computational biology The session will cover both the benefits and potential limitations of cloud based workflow execution helping you understand when and why to leverage cloud resources for your computational workloads We will use the Biome specific Shallow shotgun Inference of Functional Traits through Read mapping BioSIFTR pipeline as our case study This pipeline developed by the Microbiome Informatics team at EMBL EBI as part of the Finding Pheno project serves as an excellent example of a complex computational workflow on a public cloud platform using Nextflow...

15 July - 18 July 2025

Gene regulation: one molecule at a time

Description OverviewSpeakersProgrammeFocus panel discussionsPractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Gene expression is controlled by the dynamic action of dozens of macromolecular complexes that assemble on DNA to transcribe genes and translate mRNAs to proteins Understanding of these mechanisms has historically been driven by biochemical and structural characterisation of the players as well as probing their function through genetic deletions The genomics revolution has provided us with a near comprehensive picture of where these factors bind to regulate the genome and which transcripts are processed in various biological contexts A key limitation of the resulting models is that they are derived using data that are static by nature unfaithfully representing the dynamics of these regulatory processes in vivo The last few years has seen the independent emergence of microscopy and genomics technologies to monitor gene regulation processes with single molecule resolution Recording the dynamic function of regulatory proteins on DNA and RNA now opens opportunities to understand key parameters of the process such as its kinetics or how various activities are combined in vivo This meeting will bring together pioneers of the single molecule microscopy and single molecule genomics field as well as theoretical biologists to catalyze the emergence of a new generation of mechanistic models of the regulation of genes across each steps of the central dogma Session topics RNA processing Translation Transcription and chromatin regulation Method development Theory Speakers Speakers Nicolas Altemose Stanford University USA Edouard Bertrand Institute of Human Genetics France Lacra Bintu Stanford University USA Hinrich Boeger University of California Santa Cruz USA Jeff Chao Friedrich Miescher Institute for Biomedical Research Switzerland Shasha Chong Caltech USA Stirling Churchman Harvard Medical School USA Ibrahim Ciss Max Planck Institute of Immunobiology and Epigenetics Germany Olga Dudko University of California San Diego USA William Greenleaf Stanford University USA Val rie Hilgers Max Planck Institute of Immunobiology and Epigenetics Germany Mounia Lagha Institut de G n tique Mol culaire de Montpellier France Tineke Lenstra Netherlands Cancer Institute The Netherlands Kazuhiro Maeshima National Institute of Genetics Japan Vijay Ramani University of California San Francisco USA Efrat Shema Weizmann Institute of Science Israel Andrew B Stergachis University of Washington USA Scientific organisers Stirling Churchman Harvard Medical School USA Arnaud Krebs EMBL Heidelberg Germany Mounia Lagha Institut de G n tique Mol culaire de Montpellier France Dan Larson National Cancer Institute Center for Cancer Research USA Conference organiser Inna B sselmann EMBL Heidelberg Germany Programme Are you on social media Post using EMBLSingleMolecule and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise You can find the conference shuttle timetable here Day 1 Tuesday 15 July 2025 Time Europe Berlin Speaker12 30 14 00Registration and light refreshments14 00 14 15Opening remarks by scientific organisers14 15 17 20Session 1Chairs Stirling Churchman Daniel Larson14 15 14 35Super resolution imaging of transcription in living cellsIbrahim Cisse Max Planck Institute of Immunobiology and Epigenetics Germany14 35 14 55Breaking reversibility in eukaryotic gene regulation enhancing activator specificity via energy couplingHinrich Boeger University of California Santa Cruz USA14 55 15 15Elucidating the role of localized translation in circadian clock biology one molecule at a timeIlan Davis University of Glasgow United Kingdom15 15 15 35MYC modulates TOP2A diffusion to promote substrate detection and activity Kathryn Jackson Karolinska Institutet Sweden15 35 16 00Coffee break Meet the speakers and exhibitors16 00 16 20Imaging the life and death of mRNAs in single cellsJeff Chao Friedrich Miescher Institute for Biomedical Research Switzerlan16 20 16 40Probing the regulation of long neuronal RNAs one molecule at a timeValerie Hilgers Max Planck Institute of Immunobiology and Epigenetics GermanyNot available on demand16 40 17 00Molecular co accessibility identifies coordinated regulation between distant cis regulatory elementsKasit Chatsirisupachai EMBL Heidelberg Germany17 00 17 20Lighting up the central dogma to dissect how sharp developmental patterns are establishedMounia Lagha Institut de G n tique Mol culaire de Montpellier France17 20 18 20Speed networking in ATC Foyer18 20 20 00Dinner in EMBL Canteen20 00 22 00After dinner drinks in ATC rooftop lounge Day 2 Wednesday 16 July 2025 Time Europe Berlin Speaker09 00 11 50Session 2Chairs Mounia Lagha Arnaud Krebs09 00 09 20Replication dependent histone Repli Histo labeling dissects the physical properties of euchromatin and heterochromatin in living human cellsKazuhiro Maeshima National Institute of Genetics Japan09 20 09 40Human RNA Polymerase II is maintained in excess for robust transcriptional homeostasis Alexander Gillis University of New South Wales Australia09 40 10 00Incoherent transcription factor action leads to non monotonicity and affinity dependent activation or repression Rosa Martinez Corral Centre for Genomic Regulation Spain10 00 10 30Coffee break Meet the speakers and exhibitors10 30 10 50Analysis of single chromatin fibers reveals that a dynamic ensemble of chromatin structures underlies mitotically heritable transcriptional states Djem Kissiov University of California Berkeley USA10 50 11 10The 3D gene structure of transcriptionally distinct fly brain cell types involves complex changes in promoter proximity to both cis regulatory and non canonical elements Marcelo Nollmann Center of Structural Biology CNRS FranceNot available on demand11 10 11 30PRC1 condensate properties alter outcome of competition with SWI SNF Stefan Niekamp Harvard Medical School USA11 30 11 50Single molecule epigenetics Decoding the epigenome for cancer research and diagnosticsEfrat Shema Weizmann Institute IsraelNot available on demand11 50 13 50Lunch with guided walk in the woods13 50 16 50Session 3Chairs Kazuhiro Maeshima Vijay Ramani13 50 14 10Direct observation of transcription factor association and dissociation dynamics at an endogenous locus in living cellsTineke Lenstra Netherlands Cancer Institute Netherlands14 10 14 30Sequence dependent condensation of pioneer transcription factors on DNA Sina Wittmann Institute of Molecular Biology Germany14 30 14 50Dark proteome mediated transcriptional control in cancer at single molecule resolutionShasha Chong Caltech USAvirtual talkNot available on demand14 50 15 20Coffee break and meet the speakers15 20 15 40Measuring transcriptional repressor binding and gene silencing dynamics using single molecule footprinting Carolina Rios Stanford University USA15 40 16 00What phase s of matter is the chromosomeOlga K Dudko University of California San Diego USANot available on demand16 00 16 20Quantifying the physical genome with single moleculesWilliam Greenleaf Stanford University USA16 20 17 00Flash talk session 1 49 Adam Cawte University of Oxford UK 59 Danilo Dubocanin Stanford University USA 79 Michela Palamin EMBL Heidelberg Germany 91 Elliott Swanson University of Washington USA17 00 18 50Poster session 1 odd numbers in Helix A18 50 20 20Dinner in EMBL Canteen20 20Free evening with option of informal networking in downtown Heidelberg Day 3 Thursday 17 July 2025 Time Europe Berlin Speaker09 00 11 50Session 4Chairs Ibrahim Ciss Val rie Hilgers09 00 09 20A single cell and haplotype resolved view of normal and pathogenic gene regulationAndrew Stergachis University of Washington USA09 20 09 40Fast scanning slow binding DNA shape as a modulator in transcription factor recognition kinetics Elena Rogoulenko Weizmann Institute of Science Israel09 40 10 00A promoter proximal pausing and nuclear speckle interface for RNA processing mediated by TFIIS Andreas Mayer Max Planck Institute for Molecular Genetics GermanyNot available on demand10 00 10 30Coffee break Meet the speakers and exhibitors10 30 10 50Decoding Gene Regulation at the Single Molecule Level through Biophysical Modeling of DNA Footprinting Data Nacho Molina Institute of Genetics and Molecular and Cellular Biology France10 50 11 10Decoding YAP dynamics through charge mediated co condensates Kirstin Meyer Yale University USAvirtual talkNot available on demand11 10 11 30Single Molecule DNA Footprinting and Transcription Imaging Reveal the Molecular Mechanisms of Promoter DynamicsEdouard Bertrand Institute of Human Genetics France11 30 11 50Single cell chromatin changes associated with silencing and epigenetic memoryLacra Bintu Stanford University USA11 50 14 00Lunch and focus panel discussions 13 00 13 45Panel 1 Single molecule genomics data analysis Chair Stirling ChurchmanHelix A Seminar room 01 Panel 2 Single molecule microscopy data analysis Chairs Dan Larson Mounia LaghaKlaus Tschira Auditorium14 00 16 40Session 5Chairs Lacra Bintu Marcelo Nollmann14 00 14 20Long read single molecule sequencing methods for studying protein DNA interactions and 3D chromatin architectureNicolas Altemose Stanford University USA14 20 14 40Chromatin dynamics across seven orders of magnitude Matteo Mazzocca Massachusetts Institute of Technology USA14 40 15 00Live cell single molecule DNA binding kinetics and energetics of TFsChristof Gebhardt Ulm University GermanyNot available on demand15 00 15 30Coffee break Meet the editors15 30 15 50Super resolution imaging of mRNA reveals translation dependent alterations to mRNA structure in vivo Murali Palangat National Cancer Institute National Institutes of Health USANot available on demand15 50 16 00Flash talk session 2 82 Marco Payr EMBL Heidelberg Germany16 00 18 00Poster session 2 even numbers 18 00 20 00Conference dinner in the EMBL Canteen20 00 00 00Conference party at the Rooftop Lounge Day 4 Friday 18 July 2025 Time Europe Berlin Speaker09 30 12 15Session 6Chairs Andrew Stergachis Tineke Lenstra09 30 09 50Pervasive programmed and patterned nucleosomal distortion is a hallmark of mammalian chromatin fibersVijay Ramani University of California San Francisco USA09 50 10 10Live single transcript imaging reveals a global shift in particle dynamics during neuronal development Franka Voigt University of Z rich SwitzerlandNot available on demand10 10 10 30Revealing Chromatin Architectures Across Cellular Compartments by Fiber seqStirling Churchman Harvard University USA10 30 11 00Coffee break Meet the speakers and exhibitors11 00 11 20Deep coverage whole genome adenine footprinting unmasks hidden chromatin features Michael B Stadler University of Basel Switzerland11 20 11 40Nanog stabilizes Nanog DNA clusters to facilitate transcription Nadine Vastenhouw University of Lausanne Switzerland11 40 12 00Coordination of eRNA and mRNA in living cells at the MYC locusDaniel Larson National Cancer Institute Center for Cancer Research USA12 00 12 15Closing remarks and poster prize announcements12 15 12 30Packed lunch and departure12 30Bus shuttle to Frankfurt am Main airport12 45Bus shuttle to the main station Focus panel discussions Thursday 17 July 2025 13 00 13 45 pm Panel 1 Single molecule genomics data analysis Room Helix A Seminar room 01 Only 30 seats available first come first served Chairs Stirling Churchman Single molecule genomics data analysis represents an evolving field with diverse analytical approaches Analysis encompasses multiple computational strategies from sequence alignment and modification detection algorithms to statistical frameworks for identifying protein DNA interactions and chromatin states These methodologies have been tailored for specific experimental systems and sequencing platforms The goal of this workshop is to explore various analytical approaches followed by in depth discussions on strategy optimization across different genome scales and sequencing technologies Panel 2 Single molecule microscopy data analysis Room Klaus Tschira Auditorium Chairs Dan Larson Mounia LaghaSingle molecule microscopy data analysis is a mature yet highly idiosyncratic field Analysis relies on a host of techniques ranging from microscopy based algorithms for identification segmentation and tracking to advanced statistical inference methods for model selection and parameter estimation These approaches have been adapted and optimized for particular biological systems and imaging strategies The goal of this workshop is to provide participants with a technical overview with ample time for discussion Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 800On site PhD Student 700On site Industry 1000On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Inna B sselmann for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 17 June 2025 in some cases at special rates Please email the hotel directly quoting the booking code GRG25 01 to confirm the exact price of the room Hotel AnlageHotel Holl nder Hof Hotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg City ZentrumB B HotelISG Hotel Staycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger HeidelbergHotel Vier Jahreszeiten Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsorsNew England Biolabs Proteintech Media partners ChemBioChem a Wiley journal EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Stirling Churchman, Arnaud Krebs, Mounia Lagha, Daniel Larson

14 July - 18 July 2025

Proteomics bioinformatics

Description This course provides hands on training in the basics of mass spectrometry MS and proteomics bioinformatics You will receive training on how to use search engines and post processing software quantitative approaches MS data repositories the use of public databases for protein analysis annotation of subsequent protein lists and incorporation of information from molecular interaction and pathway databases The practical elements of the course will take raw data from a proteomics experiment and analyse it You will be able to go from MS spectra to identifying and quantifying peptides and finally to obtaining lists of protein identifiers that can be analysed further using a wide range of resources The final aim is to provide you with the practical bioinformatics knowledge you need to go back to the lab and process your own data when collected This course is organised in association with the Vlaams Instituut voor Biotechnologie VIB the Flemish Institute for Biotechnology Pre recorded material may be provided before the course starts that you will need to watch read or work through to gain the most out of the actual training event...

Barbara Etzi

14 July - 18 July 2025

Fluorescence imaging beyond intensity

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This course is organised in cooperation with Leica Microsystems Course overview As fluorescence lifetime based readouts become more accessible this course aims to provide a broad understanding of how the lifetime based information can be leveraged to solve biological questions This application centred course will provide insights into how this additional dimension of fluorescence information can help unveil functional and mechanistic information Audience This course is aimed at PhD students and Postdocs with experience in fluorescence microscopy It will enable them to better apply confocal fluorescence microscopy and in particular lifetime based readouts to their cutting edge research disseminate their gained expertise to colleagues at their home institution and eventually to develop imaging methods beyond the state of the art Modules resources 1 Measuring protein protein interactions 2 Environmental sensing with FRET based and non FRET based biosensors 3 Using fluorescence lifetime for multiplexing 4 Increasing the resolution with tauSTED 5 Endogenous fluorescence harnessing additional information and removing unwanted fluorescence like autofluorescence and background fluorescence 6 Sessions at the microscopes to practice using lifetime imaging in exemplary workflows 7 Analysis of the lifetime based information and applicative conclusions 8 Application of FLIM in human cell lines animal and plant model systems Learning outcomes Understand the basics of fluorescence lifetime Identify which types of research questions and approaches can benefit from lifetime related measurements and how to design such experiments Learn to use common biosensors probes and fluorophores and understand the additional information and contrast provided by fluorescence lifetime Understand the basis of endogenous fluorescence in particular in tissue and animal models and how fluorescence lifetime can help to exploit or cope with their signals Acquire and analyze lifetime related information in different experimental setups What past participants say about the course The atmosphere in the EMBL course Fluorescence imaging beyond intensity was highly inspiring and motivating and will open doors to new and enriching possibilities in our imaging facility Ursula Reichart University of Veterinary Medicine Vienna Austria Speakers Speakers trainers and staff Luis Alvarez Leica Microsystems CMS GmbH Germany Marie Erard Universite Paris Saclay France Dorus Gadella Uni Amsterdam Swammerdam Institute for Life Sciences Netherlands Mariano Gonzalez Pisfil Ludwig Maximilians Universit t M nchen Germany Klara Gries Max Planck Institute for Medical Research Germany Manuel Gunkel EMBL Heidelberg Germany Elizabeth Hinde University of Melbourne Australia Kees Jalink Netherlands Cancer Institute NKI Netherlands Zhongxiang Jiang Leica Microsystems CMS GmbH Germany Birgit Koch Max Planck Institute for Medical Research Germany Beatrice Lace University of Freiburg Germany Julia Marzi NMI Naturwissenschaftliches und Medizinisches Germany Sergio Padilla King s College London UK Julia Roberti Leica Microsystems CMS GmbH USA Ulf Schwarz Leica Microsystems CMS GmbH Germany Irmi Steinmetz Leica Microsystems CMS GmbH Germany Chiara Stringari CNRS Ecole Polytechnique Laboratoire d optique et biosciences France Dietrich Walsh EMBL Heidelberg Germany Dounia Zamiati Universite Paris Saclay France Giulia Zanetti Netherlands Cancer Institute NKI Netherlands Scientific organisers Luis Alvarez Leica Microsystems CMS GmbH Germany Manuel Gunkel EMBL Heidelberg Germany Birgit Koch Max Planck Institute for Medical Research Germany Andrea M lter Leica Microsystems CMS GmbH Germany Course organisers Karo Wolkersdorfer Course and Conference Officer EMBL Heidelberg Germany Michelle Steinhauer Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLFluorescenceLifetime and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings and protocol reading with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 14 July 2025 TimeDescriptionLocation08 40Hoffmann bus from ISG hotel to EMBLISG hotel bus stop09 00 11 00Course intro flash talkIC Lecture Hall11 00 12 30Fluorescence and lifetimesDorus Gadella Uni Amsterdam Swammerdam Institute for Life Sciences NetherlandsIC Lecture Hall12 30 13 30LunchEMBL Canteen13 30 14 00S1 intro get lab coatsIC Lecture Hall14 00 16 00FLIM basics in 4 parallel groupsIC Microscope rooms16 00 16 30Coffee breakIC Lecture Hall16 30 18 30Practicals in 4 parallel groups1 Halo tags FLIM on STELLARIS inverted DIVE2 Multiplexing with FPs and FLIM on STELLARIS 8 STED3 FLIM analysis including ML and AI on STELLARIS Cryo4 Label free FLIM with MP on STELLARIS DIVE CFSIC Microscope rooms18 30 18 45Wrap up sessionIC Lecture Hall18 45 19 45DinnerEMBL canteen19 45Bus from EMBL to ISG HotelEMBL bus stop Day 2 Tuesday 15 July 2025 TimeDescriptionLocation08 40Hoffmann bus from ISG hotel to EMBLISG hotel bus stop09 00 10 00Experimental Design and Considerations for Multiplexed Confocal FLIM in Live Cell ImagingBirgit Koch MPImR GermanyIC Lecture Hall10 00 10 15Coffee breakIC Lecture Hall10 15 11 15Fluorescence lifetime and F rster Resonance Energy Transfer to probe protein organization in live cellsMariano Gonzalez Pisfil Ludwig Maximilians Universit t M nchen GermanyIC Lecture Hall11 15 11 30Coffee breakIC Lecture Hall11 30 12 30cAMP quantified by lifetime imaging lifetime screening and mechano sensingKees Jalink Netherlands Cancer Institute NKI NetherlandsIC Lecture Hall12 35 Group photo Outside IC12 40 13 30LunchEMBL Canteen13 30 14 15FLIM analysis basicsIC Lecture Hall14 15 16 15Practicals in 4 parallel groups1 Halo tags FLIM on STELLARIS inverted DIVE2 Multiplexing with FPs and FLIM on STELLARIS 8 STED3 FLIM analysis including ML and AI on STELLARIS Cryo4 Label free FLIM with MP on STELLARIS DIVE CFSIC Microscope rooms16 15 16 45Coffee breakIC Lecture Hall16 45 18 45Practicals in 4 parallel groups1 Halo tags FLIM on STELLARIS inverted DIVE2 Multiplexing with FPs and FLIM on STELLARIS 8 STED3 FLIM analysis including ML and AI on STELLARIS Cryo4 Label free FLIM with MP on STELLARIS DIVE CFSIC Microscope rooms18 45 19 00Wrap up sessionIC Lecture Hall19 00 19 15EMBL bus from EMBL to ISG HotelEMBL canteen19 15 20 45Barbeque dinnerISG hotel beergarden Day 3 Wednesday 16 July 2025 TimeDescriptionLocation08 40Hoffmann bus from ISG hotel to EMBLISG hotel bus stop09 00 10 00Label free metabolic imaging across scales by Fluorescence Lifetime Microscopy of endogenous biomarkersChiara Stringari CNRS Ecole Polytechnique Laboratoire d optique et biosciences FranceIC Lecture Hall10 00 10 30Coffee breakIC Lecture Hall10 30 12 30Practicals in 4 parallel groups1 Halo tags FLIM on STELLARIS inverted DIVE2 Multiplexing with FPs and FLIM on STELLARIS 8 STED3 FLIM analysis including ML and AI on STELLARIS Cryo4 Label free FLIM with MP on STELLARIS DIVE CFSIC Microscope rooms12 30 13 30LunchEMBL Canteen13 30 16 00Practicals in 4 parallel groups5 FLIM in plants on STELLARIS DIVE CFS6 Advance FLIM biosensor on STELLARIS inverted DIVE7 FLIM in Cryo on STELLARIS Cryo8 Lifetime multiplexing and STED TauSTED Xtend on STELLARIS 8 STEDIC Microscope rooms16 00 16 30Coffee breakIC Lecture Hall16 30 19 00Practicals in 4 parallel groups5 FLIM in plants on STELLARIS DIVE CFS6 Advance FLIM biosensor on STELLARIS inverted DIVE7 FLIM in Cryo on STELLARIS Cryo8 Lifetime multiplexing and STED TauSTED Xtend on STELLARIS 8 STEDIC Microscope rooms19 00 19 15Wrap up sessionIC Lecture Hall19 15 20 15DinnerEMBL canteen20 15EMBL bus from EMBL to ISG HotelEMBL bus stop Day 4 Thursday 17 July 2025 TimeDescriptionLocation08 40Hoffmann bus from ISG hotel to EMBLISG hotel bus stop09 00 10 00virtual lectureThe phasor approach to fluorescence lifetime analysis of biosensor F rster resonance energy transfer FRET Elizabeth Hinde University of Melbourne AustraliaIC Lecture Hall10 00 10 15Coffee breakIC Lecture Hall10 15 11 15Mechanotransduction the cAMP signaling wayKees Jalink Netherlands Cancer Institute NKI NetherlandsIC Lecture Hall11 15 11 30Coffee breakIC Lecture Hall11 30 12 30Autologous NADH FAD FLIM microscopy inadvanced 3D cell culture modelsJulia Marzi NMI Naturwissenschaftliches und Medizinisches Institut GermanyIC Lecture Hall12 30 13 30LunchEMBL Canteen13 30 16 00Practicals in 4 parallel groups5 FLIM in plants on STELLARIS DIVE CFS6 Advance FLIM biosensor on STELLARIS inverted DIVE7 FLIM in Cryo on STELLARIS Cryo8 Lifetime multiplexing and STED TauSTED Xtend on STELLARIS 8 STEDIC Microscope rooms16 00 16 30Coffee breakIC Lecture Hall16 30 19 00Practicals in 4 parallel groups5 FLIM in plants on STELLARIS DIVE CFS6 Advance FLIM biosensor on STELLARIS inverted DIVE7 FLIM in Cryo on STELLARIS Cryo8 Lifetime multiplexing and STED TauSTED Xtend on STELLARIS 8 STEDIC Microscope rooms19 00 19 15Wrap up sessionIC Lecture Hall19 15 20 30Gala dinnerEMBL canteen20 30EMBL bus from EMBL to ISG HotelEMBL bus stop Day 5 Friday 18 July 2025 TimeDescriptionLocation08 40Hoffmann bus from ISG hotel to EMBLISG hotel bus stop09 00 12 15FLIM AnalysisIC12 15 13 15LunchEMBL canteen13 00 15 00Open time Hands on experimental design sample preparation discussionIC Lecture Hall15 00 15 30Final Wrap up15 40Bus to Heidelberg train station and city centerEMBL bus stop Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 550PhD Student 550Industry 1050 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for you at the ISG hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with the booking code LEF25 01 We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Media partners Microcscopy and Analysis a Wiley journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Luis Alvarez, Manuel Gunkel, Andrea Mülter

9 July 2025

Exploring macromolecular protein assemblies and their visualisation with Complex Portal

Description Protein complexes play a crucial role in driving biological functions and processes making it important to gain insights into proteins and their higher order assemblies Complex Portal is a curated resource designed to offer insights into proteins and their higher level complexes In this webinar we will introduce the portal address how we define protein complexes demonstrate how to search complexes using accession numbers or keywords specific search perform organism specific searches explore examples of complex details pages including the Complex Viewer and link outs to related databases We will also look at the new star rating given to complexes use the Complex Navigator to compare orthologous and paralogous complexes and introduce the predicted human complexes from huMAP3 0 and MuSIC maps...

7 July - 11 July 2025

Systems biology: from large datasets to biological insight

Description This course covers the use of computational tools to extract biological insight from omics datasets The content will explore a range of approaches from network inference and data integration to machine learning and logic modelling that can be used to extract biological insights from varied data types Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large scale biological data The motivation for running this course is a result of advances in computer science and high performance computing that have led to groundbreaking developments in systems biology model inference With the comparable increase of publicly available large scale biological data the challenge now lies in interpreting them in a biologically valuable manner Likewise machine learning approaches are making a significant impact in our analysis of large omics datasets and the extraction of useful biological knowledge...

Juanita Riveros

2 July 2025

A journey to FAIR bioimage data

Description Bioimaging is a pervasive and indispensable methodological approach in the life and biomedical sciences Due to the development of new technologies and the easier access to compute resources bioimaging experiments have become a big data discipline facing the same challenges as other omics technologies within the life sciences However to fully exploit the potential of bioimage data it is necessary to make the data FAIR In this webinar we will present viable solutions for storing processing analysing and first and foremost sharing bioimaging data We will introduce services provided to the scientific community that are dealing with various aspects of the bioimage data life cycle such as Where to get support for bioimage data management Local bioimage data management OMERO and beyond Annotation of bioimage data metadata ontologies REMBI etc Linking your image data with experimental protocols and analysis results Large data living in the cloud ome zarr Publication of bioimage data...

2 July - 9 July 2025

Transitions in developing systems: from theory to experiments

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Developing systems at all biological scales are subject to transitions between states of collective organisation that are critical for their function and evolution The study of transitions requires bridging biological scales and integrating diverse disciplines including statistical physics nonlinear dynamics and developmental biology Recent technological advances in quantitative biology the acquisition of big data and machine learning based analysis now make it possible to study this topic This course will give applicants the unique opportunity to closely interact with a diverse group of renowned scientists speakers trainers who work on biological transitions in fundamental developmental processes including morphogenesis signal transduction gene expression collective cell and animal behaviour Participants will be introduced to the theoretical knowledge of biological transitions and get hands on training using state of the art methods applied in depth in different model systems Audience This course is intended for graduate students and post doctoral fellows with a STEM background We aim to balance the number of participants with hands on experience and theoretical background A key criterion for selection is the potential benefit of adding novel developmental biology and biophysics methods to the participant s own research Modules resources Theory of phase transitions critical and bifurcation points Uni to multi cellular transitions in slime molds Material phase transitions in zebrafish embryos Life cycle transitions in planarian flatworms Body shape transitions in cnidarians Learning outcomes Inter disciplinary methods Highly multiplexed RNA fluorescent in situ hybridisation Quantitative imaging and analysis Machine learning based image segmentation Biophysics analysis Dynamical systems theory Feedback microscopy Hands on with single cell RNA sequencing Diverse organisms incl zebrafish dicty nematostella medaka planaria What past participants say about the course Attending Plasticity in developing systems previous title was a fantastic experience as an ECR We took part in hands on practical sessions exploring the relationship between environment and development in a range of organisms attended inspired curiosity driven research lectures and had the opportunity to meet and work alongside incredible young scientists This is the future of Developmental Biology Jennifer Love University of Manchester UK As a PhD student coming from an engineering background the exposure to a wide variety of experimental techniques and organisms played a crucial role in shaping my postdoc and future research aspirations Additionally the remarkable quality of speakers and trainers added to the overall excellence of the experience Guillermo Y ez Feli Newcastle University UK Speakers Speakers trainers and staff Karen Alim TU Munich Germany Rishica Arora EMBL Heidelberg Germany Alexander Aulehla EMBL Heidelberg Germany Matthew Benton EMBL Heidelberg Germany James Briscoe The Francis Crick Institute UK Thibaut Brunet Institut Pasteur France Iain Couzin Max Planck Institute of Animal Behaviour Germany Sohsuke Fujita EMBL Heidelberg Germany Mireia Garriga Canut EMBL Heidelberg Germany Gabriela Gastelum Urbina EMBL Heidelberg Germany Isabella Graf EMBL Heidelberg Germany Aissam Ikmi EMBL Heidelberg Germany Jun Ru Lee EMBL Heidelberg Germany Yuting Lu EMBL Heidelberg Germany Luc Lederer EMBL Heidelberg Germany Adriaan Meiborg EMBL Heidelberg Germany Caren Norden Gulbenkian Institute for Molecular Medicine Portugal Amrutha Palavalli EMBL Heidelberg Germany Nicoletta Petridou EMBL Heidelberg Germany Levin Riedel EMBL Heidelberg Germany Guillaume Salbreux Universit de Gen ve Switzerland Ali Seleit EMBL Heidelberg Germany Vanessa Stuermer EMBL Heidelberg Germany Gaurav Vaidya EMBL Heidelberg Germany Jordi van Gestel EMBL Heidelberg Germany Hanh Vu EMBL Heidelberg Germany Laeschkir W rthner EMBL Heidelberg Germany Dilan Nisa Yilmaz EMBL Heidelberg Germany Scientific organisers Karen Alim TU Munich Germany James Briscoe The Francis Crick Institute UK Nicoletta Petridou EMBL Heidelberg Germany Jordi van Gestel EMBL Heidelberg Germany Hanh Vu EMBL Heidelberg Germany Course organisers Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Alessandra Reversi EMBL Heidelberg Germany Matt Benton EMBL Heidelberg Germany Giorgia Carta EMBL Heidelberg Germany Programme Are you on social media Post using EMBLDevBio and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings and protocol reading with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Wednesday 2 July 2025 Time Europe Berlin SpeakerLocation08 40 09 30Welcome house notes and course overviewLarge Operon09 30 10 30FlashtalksLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Lecture From unicellularity to multicellularityThibaut Brunet Institut Pasteur FranceLarge Operon12 00 13 00LunchEMBL Canteen13 00 14 00Meet the speakerThibaut Brunet Institut Pasteur FranceLarge Operon14 00 15 00Introduction to practical 1 Theory of phase transitions critical and bifurcation pointsIsabella Graf EMBL Heidelberg GermanyJames Briscoe The Francis Crick Institute UKLarge Operon15 00 19 00Practical session 1 Theory of phase transitions critical and bifurcation pointsIsabella Graf EMBL Heidelberg GermanyJames Briscoe The Francis Crick Institute UK1 trainer from Briscoe lab1 trainer from Alim lab2 trainers from the Graf groupComputer Training Lab19 00 20 00DinnerEMBL Canteen Day 2 Thursday 3 July 2025 Time Europe Berlin SpeakerLocation09 00 09 10Overview of the dayNicoletta Petridou EMBL Heidelberg GermanyLarge Operon09 10 09 40Introduction to practical 2 Aggregative development in wildtype slime mold speciesJordi van Gestel EMBL Heidelberg GermanyLarge Operon09 40 12 30Practical session 2A Aggregative development in wildtype slime mold speciesJordi van Gestel EMBL Heidelberg Germany4 trainers from the van Gestel groupTraining Lab12 30 13 30LunchCanteen13 30 14 30Lecture Fundamental principles of collective animal behaviourIain Couzin MPI GermanyLarge Operon14 30 15 30Meet the speakerIain Couzin MPI GermanyLarge Operon15 30 16 00Coffee BreakOperon Foyer16 00 17 00Lecture Biological physics and morphogenesisKaren Alim TU Munich GermanyLarge Operon17 00 18 00Meet the speakerKaren Alim TU Munich GermanyLarge Operon18 00 19 00DinnerOperon Foyer19 00 21 00Poster Session 1 odd numbers Operon Foyer Day 3 Friday 4 July 2025 Time Europe Berlin SpeakerLocation09 20 09 30Overview of the dayJames Briscoe The Francis Crick Institute UKLarge Operon09 30 10 30Lecture Theoretical physics of biological developmentGuillaume Salbreux University of Geneva SwitzerlandLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Meet the speakerGuillaume Salbreux University of Geneva SwitzerlandLarge Operon12 00 13 00LunchEMBL Canteen13 00 13 30Introduction to practical 3A Tissue material phase transitions in developing zebrafish embryosNicoletta Petridou EMBL Heidelberg GermanyLarge Operon13 30 14 00Introduction to practical 3B Dissecting FGF Notch dynamic signalling interactions during Medaka somitogenesis using optogeneticsAlexander Aulehla EMBL Heidelberg GermanyLarge Operon14 00 18 30Practical session 3A Tissue material phase transitions in developing zebrafish embryosNicoletta Petridou EMBL Heidelberg Germany2 trainers from the Petridou groupDB Unit14 00 18 30Practical session 3B TBCAlexander Aulehla EMBL Heidelberg Germany2 trainers from the Aulehla groupDB Unit18 30 19 30DinnerOperon Foyer19 30 21 30Poster Session 2 even numbers Operon Foyer Day 4 Saturday 5 July 2025 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayKaren Alim TU Munich GermanyLarge Operon09 00 12 00Data analysis for Practicals 3 A BTrainers from Petridou and Aulehla groupsComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 13 30Introduction to practical 4 Size dependent physiological changes duringthe life cycle of planarian flatwormsHanh Vu EMBL Heidelberg GermanyLarge Operon13 30 18 00Practical session 4 Size dependent physiological changes during the life cycle of planarian flatwormsHanh Vu EMBL Heidelberg Germany4 trainers from the Vu groupComputer Training Lab18 00 19 00DinnerEMBL Canteen Day 5 Sunday 6 July 2025 Time Europe Berlin Speaker00 00 00 00Free day Day 6 Monday 7 July 2025 Time Europe Berlin SpeakerLocation09 20 09 30Overview of the dayJordi van Gestel EMBL Heidelberg GermanyLarge Operon09 30 10 30Lecture TBCCaren Norden Gulbenkian Institute for Molecular Medicine PortugalLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Meet the speakerCaren Norden Gulbenkian Institute for Molecular Medicine PortugalLarge Operon12 00 13 00LunchEMBL Canteen13 00 13 30Introduction to practical 5 Control of the larva polyp transition via nerve derived factorsAissam Ikmi EMBL Heidelberg GermanyDB Unit13 30 18 00Practical session 5 Control of the larva polyp transition via nerve derived factorsAissam Ikmi EMBL Heidelberg Germany4 trainers from the Ikmi groupDB Unit18 00 19 00DinnerEMBL Canteen19 00 21 00Round table Career Development led by the organisersATC Roof Top Lounge Day 7 Tuesday 8 July 2025 Time Europe Berlin SpeakerLocation09 20 09 30Overview of the dayHanh Vu EMBL Heidelberg Germany09 30 10 30Practical session 2B Aggregative development in wildtype slime mold species Group 1DB Unit10 30 11 00Coffee break11 00 12 00Practical session 2B Aggregative development in wildtype slime mold species Group 2DB Unit12 00 13 00LunchEMBL Canteen13 00 15 00Data analysis for practicals 4 and 5Trainers from Vu and Ikmi groupsComputer Training Lab15 00 18 00Preparation time for student presentations extra time to visit the lab and ask questions to the DB trainersATC Courtyard Room18 00 18 30Molecular Instruments talkATC Courtyard Room18 30 22 30BBQ and PartyEMBL Canteen Day 8 Wednesday 9 July 2025 Time Europe Berlin Speaker08 50 09 00Overview of the dayLarge Operon09 00 10 30Student presentationsLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Feedback sessionLarge Operon12 00 13 00Lunch Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This course includes accommodation and transportation to and from the ISG Hotel to the venue The reduced fees and accommodation are covered thanks to the Theory EMBL Transversal Theme Academia 550PhD Student 550Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation will be booked for the selected participants at the ISG Hotel for the default dates of 1 to 9 July 2025 In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISG Hotel during your stay We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Event software Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Karen Alim, James Briscoe, Jordi van Gestel, Nicoletta Petridou, Hanh Vu

25 June 2025

Open FAIR data: the role of public data archives

Description Scientific progress relies on open FAIR data Describing datasets with rich metadata and appropriate standards and submitting these to public archives is crucial in linking different data types in an open accessible and sustainable manner This webinar will introduce two public archives BioSamples and BioImage Archive After a brief overview we will provide information on how you can use these repositories to make your data open and FAIR with a particular focus on complex multi modal datasets Please note that by clicking on Access Materials a pptx file with the slides of the presentation will be automatically downloaded...

24 June - 27 June 2025

New approaches and concepts in microbiology

Description OverviewSpeakersProgrammeEMBO trainingPractical informationSponsorsMedia kitAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview This symposium is the seventh edition of a successful series started in 2013 and held biannually since It has established itself as a must attend fixture in the calendar for scientists working with bacteria and new technologies The meeting covers a broad range of cutting edge topics in microbiology featuring diverse research Emphasis is placed on novel approaches and technologies from systems based to single cell that drive each field or have the potential to revolutionise future microbiology research The meeting is always oversubscribed and manages to bring together scientists from different areas who usually don t meet creating a highly interactive and dynamic atmosphere Session topics Bacterial systems biology Bacterial cell biology and protein machines Microbiomes Environment and evolution Pathogenesis and phage Antibiotic discovery mechanisms and resistance What past participants say about the conference Amazing opportunity to learn reflect network and collaborate One stop for everything hot and happening in the field of microbiology I would highly recommend Swagatika Dash University of Osnabr ck Germany The conference was an amazing combination of excellent speakers networking opportunities a lot of unpublished results and great catering in a beautiful setting Celien Bollen VIB KU Leuven Belgium Speakers Ami Bhatt Stanford University USA David Bikard Institut Pasteur France Ariane Briegel Institut Pasteur France Rachna Chaba IISER Mohali India Guillaume Dumenil Institut Pasteur France Peter Fineran University of Otago New Zealand Martin Kaltenpoth Max Planck Institute for Chemical Ecology Germany Kimberly Kline University of Geneva Switzerland Sanna Koskiniemi Uppsala University Sweden Hannes Link University of T bingen Germany Lisa Maier University of T bingen Germany Despoina Mavridou The University of Texas at Austin USA Jeffrey Moffitt Boston Children s Hospital USA Elin Org University of Tartu Estonia Alexandre Persat EPFL Switzerland Martin Polz University of Vienna Austria Jeremy M Rock The Rockefeller University USA Kimberley Seed University of California Berkeley USA Jordi van Gestel EMBL Heidelberg Germany J rg Vogel Helmholtz and University of W rzburg Germany Julia Vorholt ETH Z rich Switzerland Harris Wang Columbia University USA Scientific Organisers Pascale Cossart Institut Pasteur France Sophie Helaine Harvard Medical School USA KC Huang Stanford University USA Michael Laub Massachusetts Institute of Technology USA Nassos Typas EMBL Heidelberg Germany Conference Organiser Maria Bacadare EMBL Heidelberg Germany Programme Are you on social media Post using EESMicrobiology and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here Please find the conference bus schedule here Day 1 Tuesday 24 June 2025 Time Europe Berlin Speaker12 00 13 45Registration and light refreshments13 45 14 00Opening remarks14 00 18 30Session 1 Bacterial Systems BiologyChairs Uwe Sauer ETH Z rich Switzerland Nassos Typas EMBL Heidelberg Germany14 00 14 30Compensatory evolution in NusG improves fitness of drug resistant M tuberculosisJeremy M Rock The Rockefeller University USA14 30 14 45The phenotypic landscape of the mycobacterial cellHoria Todor University of California San Francisco USA14 45 15 15Understanding and engineering bacterial metabolism with CRISPR and metabolomicsHannes Link University of T bingen Germany15 15 15 30PIRT Seq a high resolution whole genome assay to identify protein coding genesEmily Goodall University of Queensland Australia15 30 15 45New approaches for forward and reverse genetics in bacteriaDavid Basta Brigham and Women s Hospital USA15 45 16 00Dual phenotype and functional prediction with genome free statistical systems genomicsJulia Salzman Stanford University USANot available on demand16 00 16 30Coffee break and meet the speakers16 30 17 00Imaging the transcriptome in bacteria reveals single cell heterogeneity and niche adaptationJeffrey Moffitt Boston Children s Hospital USANot available on demand17 00 17 30Spatial metagenomics culturomics and in situ editing of microbiomesHarris Wang Columbia University USA 17 30 17 45A toolkit for transposon libraries and functional genomics in intestinal Bacteroidales speciesCarlos Voogdt EMBL Heidelberg Germany17 45 18 00Mapping the functional proteome of gut microbiome speciesDimitris Papagiannidis EMBL Heidelberg Germany18 00 18 30Harnessing diversity generating retroelements for in vivo targeted hyper mutagenesisDavid Bikard Institut Pasteur FranceNot available on demand18 30 20 00Dinner in Canteen20 00 22 30After dinner drinks Day 2 Wednesday 25 June 2025 Time Europe Berlin Speaker09 15 12 00Session 2 MicrobiotasChairs Pascale Cossart Institut Pasteur FranceKC Huang Stanford University USA09 15 09 45Mobile DNA in the microbiomeAmi Bhatt Stanford University USA09 45 10 00Spatial coordination of Ruminococcus bromii enzymes promotes its ability to degrade resistant starch in the human gut microbiomeBenedikt Wimmer University of Zurich Switzerland10 00 10 30Drugging the gut microbiome From unintended side effects to targeted modulationLisa Maier University of T bingen GermanyNot available on demand10 30 11 00Coffee break and meet the speakers11 00 11 15Gut microbiota within host evolution enforces colonization resistance against enteric infectionMarta Salvado Silva Technical University Munich Germany11 15 11 30Systematic testing for drug biotransformation across bacterial strains that confers resistance to gut commensalsMariia Beliaeva EMBL Heidelberg Germany11 30 12 00Uncovering microbiome health interactions using population based cohortsElin Org University of Tartu EstoniaNot available on demand12 00 12 30Flash talks 2 min each 47 Nadia Aftab 71 Jacob Bobonis 87 Yorben Casters 93 Fabian Cornejo 157 Karyna Karneyeva 187 Amandine Maire 195 Giselle McCallum 201 Hosni Nedjar 255 Philipp Walch 66 Doroth e Berthold 68 Marlene Birk 76 Maj Brodmann 98 Andrea Daveri12 30 13 15Lunch and meet the editors13 15 15 15Poster session 1 odd numbers 15 15 18 30Session 3 Cell Biology Protein machinesChairs Fr d ric Barras Institut Pasteur France andAndrea Puhar Queen s University Belfast UK15 15 15 45Cryo Electron Tomography contributes to our understanding of bacterial interactions with their environmentAriane Briegel Institut Pasteur France15 45 16 00Real time tracking of early ribosomal RNA transcription and processingAnastasiia Chaban EMBL Heidelberg GermanyNot available on demand16 00 16 15Endogenous fatty acid degradation and stationary phase adaptationEmmanuelle Bouveret Institut Pasteur FranceNot available on demand16 15 16 45Consequences of toxin and antibiotic induced metabolic changes on bacterial growth survival and multi cellularitySanna Koskiniemi Uppsala University Sweden16 45 17 15Coffee break and meet the speakers17 15 17 45It s a sabotage Pseudomonas aeruginosa exploits airway regeneration to persist during chronic infectionsAlexandre Persat EPFL Switzerland17 45 18 00A novel approach to discovering translational recoding events near stop codonsMichele Felletti Max Planck Institute for Multidisciplinary Sciences Germany18 00 18 30Integration of long chain fatty acid metabolism with stress response in E coliRachna Chaba IISER Mohali IndiaNot available on demand18 30Free evening downtown Day 3 Thursday 26 June 2025 Time Europe Berlin Speaker09 15 12 15Session 4 Environment EvolutionChairs Michael Laub Massachusetts Institute of Technology Howard Hughes Medical Institute USAOlga Schubert Eawag ETH Zurich Switzerland09 15 09 45Engineering novel endosymbiosis by bacteria implantationJulia Vorholt ETH Z rich SwitzerlandNot available on demand09 45 10 00The extended life cycle of phage Flo Baert KU Leuven BelgiumNot available on demand10 00 10 30Going defense mode Bacillus subtilis switch likeadaptations to protistan predationJordi van Gestel EMBL Heidelberg GermanyNot available on demand10 30 11 00Coffee break and meet the speakers11 00 11 30Developing tractable systems to understand insect microbe symbioses from the molecular to the organismic levelMartin Kaltenpoth Max Planck Institute for Chemical Ecology GermanyNot available on demand11 30 11 45Sedentary chromosomal integrons as biobanks of bacterial anti phage defense systemsBaptiste Darracq Institut Pasteur France11 45 12 15Genome wide selective sweeps as a fundamental structuring force in the human microbiomeMartin Polz University of Vienna Austria12 15 12 45Flash talks 2 min each 138 Carlos Hernandez Ortego 140 Camille Herrou 146 Dmitry Ignatov 148 Olga Iwanska 152 Axel Janssen 164 Mark ta Kobersk 172 Xu Kuang 182 Anna Lopatina 184 Marta Louren o 206 Anna Olina 212 Luc a P rez 214 Jamiema Sara Philip 248 Chia En Tsai12 45 13 45Lunch and meet the editors13 45 15 45Poster session 2 even numbers 15 45 19 15Session 5 Pathogenesis PhageChairs Sophie Helaine Harvard Medical School USAFrancois Rousset Ciri France15 45 16 15Bacterial growth under confinement requires transcriptional adaptation to resist metabolite induced turgor pressure build upGuillaume Dumenil Institut Pasteur France16 15 16 30Bacterial adaptation to oxidative stress beyond classic oxidantsBenjamin Ezraty CNRS Aix Marseille University France16 30 17 00Pathogenesis of Enterococcal biofilm associated infectionKimberly Kline University of Geneva SwitzerlandNot available on demand17 00 17 15Discovery of bacterial immune system family that specifically inhibits nucleus forming Jumbo PhagesYuping Li University of California San Francisco USA and University of Basel Switzerland17 15 17 45Coffee break and meet the speakers17 45 18 15Phage defence and counter defence mechanismsPeter Fineran University of Otago New Zealand18 15 18 30Hyper promiscuous phosphorylation by phage T7 kinase disarms bacterial immune systemsTara Bartolec EMBL Heidelberg Germany18 30 18 45Systematic deciphering of E coli host phage interactions using high throughput genetic screens enables genome based prediction of phage adsorption strategiesLucas Moriniere University of California Berkeley USA18 45 19 15Fighting with phages how Vibrio cholerae defends against viral attackKimberley Seed University of California Berkeley USA19 15 20 30Gala conference dinner in the canteen20 30 00 00Party with band Day 4 Friday 27 June 2025 Time Europe Berlin Speaker09 15 12 15Session 6 Antibiotic Discovery Resistance MechanismsChairs Ana Rita Brochado University of T bingen Germany andAndr Mateus Ume University Sweden09 15 09 45Programmable RNA antibiotics reveal essential genes in phage host interplayJ rg Vogel Helmholtz Centre for Infection Research Germany09 45 10 00The epitranscriptomic response of Escherichia coli to stressSebastian Riquelme Ludwig Maximilians Universit t M nchen GermanyNot available on demand10 00 10 15The natural diversity of E coli transporter dependent capsulesElisabetta Cacace ETH Z rich SwitzerlandNot available on demand10 15 10 45Protein folding elements enable genetic innovation in antibiotic resistance genesDespoina Mavridou The University of Texas at Austin USA10 45 11 15Coffee break and meet the speakers11 15 11 30MtvS interacts with RNA polymerase to regulate the Francisella type V A CRISPR Cas systemMaj Brodmann The Rockefeller University USA11 30 11 45Attachment of the Outer Membrane to Peptidoglycan Enables Vital Periplasmic Pressure Build upMichael Deghelt UCLouvain de Duve Institute Belgium11 45 12 00Expeditious elimination of donor cell illuminates plasmid gene expression program during conjugationMeng Wen French National Centre for Scientific Research CNRS FranceNot available on demand12 00 12 15Poster awards closing remarks farewell12 15Packed lunches12 4513 00Bus to Frankfurt airport Terminal 1 Downtown bus EMBO training EMBO training session How to write a scientific paper Please note that this training requires separate registration via annika diederich embo org Overview This training module introduces the fundamental elements of publishing scientific research focusing on the structure and content of a manuscript how to assemble effective figures and how to write impactful titles and abstracts Led by an experienced EMBO Press scientific editor participants will explore the strategic planning for publication including determining authorship organising data and selecting the most appropriate journal for submission The session will run for 4 hours on the first morning of the symposium and will provide an engaging and interactive learning environment Date Tuesday 24 June 2025 Time 8 30 12 30 Europe Berlin It will include hands on exercises group work and lively discussions to help participants develop a practical understanding of how to write a successful scientific paper Audience This training session is designed for a maximum of 20 PhD students and postdocs who want to improve their scientific writing and publishing skills Learning outcomes At the end of the module participants will Understand the purpose and the structure of each section of a scientific paper title and abstract introduction results materials and methods discussion references and data availability Gain practical experience in assembling figures and writing titles and abstracts Receive guidance from instructors and peer feedback to refine the critical components of a successful scientific manuscript Registration For more information and to register please contact annika diederich embo org Registration deadline 10 June 2025 The training session is limited to 20 participants who will be selected on a first come first served basis Selected participants must commit to attending the entire module Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Maria Bacadare for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Monday 26 May in some cases at special rates Please email the hotel directly quoting the booking code EES25 06 to confirm the exact price of the room Hotel AnlageHotel Holl nder Hof Premier Inn Heidelberg City ZentrumHotel Bayrischer Hof Hotel ibis HeidelbergStaycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergThe Heidelberg Exzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHilton HeidelbergHotel Monpti Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsor Elsevier MP Biomedicals Event supporter Media partners ChemBioChem a Wiley journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal The EMBO Journal an EMBO Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually...

Pascale Cossart, Sophie Helaine, KC Huang, Michael Laub, Nassos Typas

24 June - 26 June 2025

Data visualisation for biology

Description This course will give insights into and practical experience in data visualisation for exploring complex and multi dimensional biological data Biological and life sciences data often consists of multiple dimensions a combination of numerical values ordered data categories and time series To make sense of this data simple plots like scatterplots barcharts and boxplots are often not enough Still visualisation is critical in gaining deep insight into the data This is why many custom visualisations originated in the biological field In this course we will dive into the topic of visualisation of complex biological data and how it can be used to gain insight into and get a feel for a dataset so that targeted analyses can be defined It will be delivered through a mixture of lectures and workshop sessions and will provide hands on experience in developing visualisations The course will focus on working with omics e g genomics transcriptomics data rather than e g imaging data...

Anca Belu

16 June - 20 June 2025

Data science for life scientists

Description This course will introduce life scientists to practical data science topics used in life sciences such as data handling and visualisation statistical analysis application of AI and use of publicly available databases You will initially be introduced to data science theory and practice including best practices for undertaking analyses data management and reproducibility The course will provide hands on training in tools and resources appropriate to your research including introducing the use of Python for handling and visualising data statistical analysis and the application of machine learning Group projectsThis course includes group projects where you will be placed in small groups to work together on a challenge set by trainers from EMBL EBI This allows you to explore the data sciences methods and resources you will learn about during the course and apply them to a set problem providing you with hands on experience The group work will culminate in a flash talk session involving everyone on the final day of the course Groups are mentored and supported by the trainers who set the initial challenge but the groups will be responsible for driving their projects forward with all members expected to take an active role There are two different group project topics gene expression and protein structure Both these projects will provide an opportunity for participants to apply the knowledge and skills learnt during the other sessions of the course including data handling in Python data visualisation statistics and machine learning The projects will also allow participants to gain experience of using EMBL EBI data resources including Expression Atlas and the Single Cell Expression Atlas for the gene expression project and the resources PDBe and AlphaFold for the protein structures project You will be asked during your application to select the group project topic you would most benefit from The projects cover mammalian data sets however in many cases the methods and approaches taught are transferable to data from various species...

Meredith Willmott

16 June - 17 June 2025

In science we trust?

Description OverviewSpeakersProgrammePractical informationCall for postersSponsorsMedia kit Overview The official registration deadline for this event has passed however places are still available please get in touch if you wish to enquire about late registration This conference will take place as an in person meeting on site at EMBL Heidelberg Conference overview We live in an era characterised by dazzling scientific and technological progress on an unprecedented scale From the application of new gene editing techniques pioneering stem cell research or rapid vaccine development to emerging technologies such as AI or organoid research advances in life sciences offer a myriad of potential benefits to society However these scientific endeavours exist against a backdrop of misinformation and disinformation in the scientific arena which have the potential to cast a shadow on the public perception of science From attitudes surrounding scientific issues in the pandemic highly publicised cases of scientific fraud and misconduct or ethical issues in research which may cross into the realms of science fiction the issue of societal trust in science is never far from the public consciousness How have scientific developments over the past 100 years shaped the public view of science what responsibility do scientists have towards society and what does the future hold for the indivisible relationship that exists between science and society This conference will analyse the importance of public trust in science in a post truth society from public involvement to implications on funding and resource allocation and the political consequences of losing societal trust and buy in Above all it will ask what role we can all play in shaping the future path of increased societal trust in science Speakers Keynote speakers Ralf Bartenschlager Heidelberg University Hospital Germany Maura Hiney University College Dublin Ireland Speakers and panelists Ulrike Beisiegel University of G ttingen Germany Ben Bleasdale Campaign for Science and Engineering United Kingdom Perihan Elif Ekmekci TOBB University of Economics and Technology Turkey Caitjan Gainty King s College London United Kingdom Giorgia Guglielmi Freelance Science Journalist Switzerland Resham Kotecha Open Data Institute United Kingdom Remote panelist Mihalis Kritikos European Commission Belgium Remote panelist Rebecca Lawrence F1000 United Kingdom Danielle Metzler Falling Walls Foundation Germany Henriikka Mustajoki Open Science Finland Malvika Sharan The Alan Turing Institute United Kingdom Csaba Szabo University of Fribourg Switzerland Veli Vural Uslu TAP The Awesome Potatoes Science Theater Heidelberg Germany Victoria Tianjing Yan EMBL Heidelberg Germany Hub Zwart Erasmus School of Philosophy The Netherlands Committee Geoffrey BarnettEMBL Heidelberg GermanyJ rgen DekaEMBL Heidelberg GermanyErnesto de la Cueva BuenoEMBL Heidelberg GermanyBriony JacksonEMBL EBI Hinxton United KingdomNatalia KretEMBL Heidelberg GermanyRuairi McEvoyEMBL EBI Hinxton GermanyMaria PapanikoaouEMBL Heidelberg GermanyBianca SchmittEMBL Heidelberg GermanyVictor Secco Ca Foscari University of Venice ItalyGemma WoodEMBL EBI Hinxton United Kingdom Organisers Flavien Affaki EMBL Heidelberg Germany Sandra Bendiscioli EMBO Germany Thomas Keane EMBL EBI Hinxton United Kingdom Bernd Pulverer EMBO Press Germany Giorgia Renne EMBL Heidelberg Germany Gabriele Rinck EMBL EBI Hinxton United Kingdom Lucia Schmitz EMBL Heidelberg Germany Conference organiser Nathalie Sneider EMBL Heidelberg Germany Programme Are you on social media Post using SciSoc2025 and don t forget to tag EMBLEvents This conference will take place as an in person meeting on site at EMBL Heidelberg Please note that the programme is subject to change Some speakers may need to join virtually to give their talk The conference booklet with information on talks and posters that will be presented at the event is available here View the poster listing here Please find the conference bus schedule here Day 1 Monday 16 June 2025 Time Europe Berlin Speaker11 45 12 00Registration for participants joining The World of Molecular Biology tour12 00 13 00Tours of The World of Molecular Biology an EMBL exhibition limited places registration will be possible ahead of the conference 12 00 13 30Arrival and registrationLight refreshments available13 30 13 45Welcome remarks and housenotesGabriele Rinck EMBL EBI Hinxton United KingdomJan Korbel EMBL Heidelberg GermanyDay 1 TRUST for Science13 45 14 30Keynote lecture 1 Evolution of trust in science during the Covid 19 pandemics A virologists experienceRalf Bartenschlager Universitatklinikum Heidelberg Germany14 30 15 30Session 1 Past present and future of societal trust in scienceChair Lucia Schmitz EMBL Heidelberg Germany14 30 15 00The evolution of dist trust in science from the late 20th century to the presentCaitjan Gainty Kings College London United Kingdom15 00 15 30How and how much does public trust affect scientific and technological research Ben Bleasdale Campaign for Science Engineering United Kingdom 15 30 15 50Flash talks from poster presenters 1 minute 1 slide Poster numbers 11 12 13 14 15 17 19 22 23 24 25 26 27 15 50 16 30Coffee break and poster viewing16 30 18 15Session 2 The new challenges of conducting research and their effect on community trustChair Giorgia Renne EMBL Heidelberg Germany16 30 17 00Reproducibility crisis in biomedical research and what to do about itCsaba Szabo University of Fribourg Switzerland17 00 17 30Towards responsible research assessment to address research integrity and support trust in scienceRebecca Lawrence F1000 DORA United Kingdom17 30 18 15Panel discussion 1 Focus on AIChair Jan Korbel EMBL Heidelberg GermanyPanelists Perihan Elif Ekmekci TOBB University TurkeyResham Kotecha The Open Data Institute United Kingdom remote panelist Mihalis Kritikos European Commission Belgium remote panelist 18 15 18 30Closing remarks of Day 118 30 19 30Meet the speakers of Day 1 and Poster viewingwith pre dinner drinks19 30 21 30Dinner in the EMBL Canteen Day 2 Tuesday 17 June 2025 Time Europe Berlin SpeakerDay 2 SCIENCE for Trust09 00 09 45Keynote lecture 2 How can policy contribute to trustworthy science insights from developing the European Code of Conduct for Research IntegrityMaura Hiney University College Dublin Institute for Discovery Ireland09 45 10 45Session 3 Science communication and participatory science to boost public trust in researchChair Sandra Bendiscioli EMBO Germany09 45 10 15Trust in science in an era of social fragmentationHub Zwart Erasmus School of Philosophy The Netherlands10 15 10 45Mini panel How to communicate science effectively and creatively with EMBL Alumni Panelists Giorgia Guglielmi Freelance Science Journalist SwitzerlandVeli Vural Uslu TAP The Awesome Potatoes Science Theater Heidelberg Germany10 45 11 30Coffee Break including Poster viewing11 30 12 30Session 4 How to make science trustworthy The pivotal role of research integrityChair Bernd Pulverer EMBO Press Germany11 30 12 00Role of Ombudsperson in research integrity and beyondUlrike Beisiegel Goettingen University Germany12 00 12 30Falling the walls of mistrust in scienceDanielle Metzler Falling Walls Foundation Germany12 30 13 15Panel discussion 2 Focus on Open SciencePanelists Victoria Yan EMBL Heidelberg GermanyHenriikka Mustajoki Open Science FinlandMalvika Sharan Alan Turing Institute13 15 13 30Closing remarksLucia Schmitz EMBL Heidelberg Germany13 30 14 30Light lunch and Meet the speakers from Day 214 00 15 00Tours of The World of Molecular Biology an EMBL exhibition limited places registration will be possible ahead of the conference Practical information The official registration deadline for this event has passed however places are still available please get in touch if you wish to enquire about late registration Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Standard 40Student 20 If you are under 18 years of age and interested in attending this event please contact us directly to ask about registration options first EMBL staff interested in attending this event should register using the staff registration page available on the intranet Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually Types of payments accepted are international bank transfers and credit card payments Poster abstract submission Please find more details under the Call for posters tab Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Thursday 15 May 2025 in some cases at special rates Please email the hotel directly quoting the booking code SNS25 01 to confirm the exact price of the room Hotel Bayrischer Hof Hilton HeidelbergPremier Inn Heidelberg CityB B HotelHotel ibis HeidelbergStaycity Aparthotel HeidelbergExzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Please find the conference bus schedule here Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference will be published ahead of the event Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans Boeckler Strasse bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Call for posters The deadline for submitting a poster has now passed The In Science We Trust Conference organised by EMBL Bioethics Services within its Science Society Programme aims to explore the evolution of trust within the research landscape and address the emerging challenges facing the research community today We encourage submissions from researchers scholars life sciences students as well as policymakers science educators and communicators engaged in fostering trust integrity and transparency in research The conference seeks to facilitate interdisciplinary dialogue and collaboration among stakeholders invested in promoting trustworthiness across all domains of research The conference will include dedicated time for viewing posters and for poster presenters to showcase their work and engage in meaningful discussions with peers from diverse fields Poster focus areas We welcome poster submissions that explore Projects in science communication and science education that actively work to improve public trust in scientific knowledge institutions and processes Initiatives within research projects that prioritise integrity transparency and ethical practices aiming to strengthen trust within the scientific community Innovative methods or approaches that address misinformation and disinformation in science with the goal of restoring or protecting public trust Collaborative efforts between researchers and communities that promote open science practices or encourage citizen science as a means of enhancing transparency and trust Exploration of how artificial intelligence AI and machine learning ML can be responsibly integrated into research and communication ensuring transparency fairness and trustworthiness in their applications We encourage submissions that showcase real world applications collaborative approaches and measurable outcomes that contribute to building and sustaining trust in the research landscape Submission guidelines All posters should reflect the conference theme and address relevant issues related to trust in research Proposals must be submitted online through the conference abstract submission portal by Monday 7 April 2025 Submissions should adhere to the specified word limits and formatting guidelines outlined below Candidates should provide all the information requested to complete their submission Incomplete submissions will not be reviewed Each submission must include a brief biography 100 words for all presenters All presenters are required to complete a registration form pay the registration fee and cover all travel and personal expenses All this information should be included in the proposal to be considered complete Title One or more Focus areas Abstract 250 words 2 3 Learning objectives 1 3 Keywords Presenter information Name Institutional Affiliation city and state Email address Brief biography Review Process Submissions will undergo a review process conducted by the EMBL Bioethics Services Criteria for evaluation include relevance to the conference theme clarity of presentation scholarly rigor and potential contribution to the field Submitters will be notified of the results of the review by the end of April Communication and timeline Call for proposals opens November 2024 Deadline for proposal submissions 7 April 2025 Authors notified of acceptance decision 14 April 2025 Trust in Research Conference 16 17 June 2025 Contact Information For enquiries regarding the call for proposals or conference logistics please contact Nathalie Sneider We look forward to receiving your innovative proposals and fostering meaningful discussions on the evolving landscape of trust in research Sponsors Media partners ChemBioChem a Wiley journal EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Flavien Affaki, Sandra Bendiscioli, Thomas Keane, Bernd Pulverer, Giorgia Renne, Lucia von Bredow

15 June - 20 June 2025

Imaging-based spatial-omics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The aim of the course is to provide participants a comprehensive introduction to the various methods of spatial omics and in particular those of multiplex immunofluorescence and spatial transcriptomics We want to provide a general overview of the methods and assist researchers choose the right method for their needs With hands on practicals the course will teach participants how to carry out open source imaging based methods for cost effective spatial transcriptomics and multiplex immunofluorescence The course will cover all experimental stages including custom reagent preparation sample preparation and data acquisition with various microscopy modalities as well as image processing and basic data analysis Audience This course is open to PhD students postdocs and staff We seek participants from the following backgrounds tissue biology or biomedicine with experience in basic tissue handling immunofluorescence and basic microscopy Modules Resources Tissue sample preparation In situ sequencing Oligo probe design In situ signal amplification Antibody DNA conjugation Multiplexed protein imaging IBEX and Immuno SABER Basic data processing and analysis Learning outcomes Familiarity with spatial omics methods Protocol optimisation Knowhow for imaging based spatial omics workflows Knowledge to choose the most suitable methods for own projects Understanding the data processing and analysis needs What past participants say about the course Incredibly motivating experience packed with great scientific discussions and networking Within just one week we learned how easy it is to replicate some of the daunting spatial techniques in the lab and I cannot wait to bring this knowledge back to my institute Ines Boehm Biozentrum University of Basel Switzerland This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Speakers trainers and staff Omer Bayraktar Wellcome Sanger Institute UK Francesco Bacchi CrestOptics Italy Fabian Coscia Max Delbr ck Center Germany Colin Chu University College London UK Alvaro Crevenna EMBL Rome Italy Yulia Ermakova EMBL Heidelberg Germany Arne Giebeler Nikon Germany Sebastian Gonzalez Heidelberg University Hospital Germany Marco Grillo Stockholm University Sweden Julian Gurgo EMBL Rome Italy Felix Hartmann DKFZ Germany Kristina Jevdokimenko EMBL Heidelberg Germany Marina Peralta EMBL Rome Italy Emerald Perlas EMBL Rome Italy Andrea Radtke Leica Microsystems USA Robert Reinhardt EMBL Heidelberg Germany Sinem Saka EMBL Heidelberg Germany Denis Schapiro Heidelberg University Hospital Germany Oliver Stegle EMBL Heidelberg Germany Caterina Strambio De Castillia University of Massachusetts USA Virtual speaker Xiao Wang Broad Institute MIT and Harvard Cambridge USA Virtual speaker Scientific organisers Alvaro Crevenna EMBL Rome Italy Emerald Perlas EMBL Rome Italy Andrea Radtke Leica Microsystems USA Sinem Saka EMBL Heidelberg Germany Course organisers Iva Gavran Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Senior Scientific Training and Digital Learning Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBOSpatialOmics and don t forget to tag EMBLEvents Some speakers will join virtually to give their lecture or Q A and the programme is subject to change Onboarding day a few days ahead of the course 11 June Day 1 Sunday 15 June 2025 Time Berlin Europe SpeakerLocation13 15 13 30Bus from ISG hotel to EMBL13 30 13 45 Arrival and registration with refreshmentsCourtyard Room A B13 45 13 55House notes and safety rules Alvaro Crevenna EMBL Rome ItalyCourtyard Room A B13 55 14 15Introduction to Responsible conduct of research Alvaro Crevenna EMBL Rome ItalyCourtyard Room A B14 15 15 15Introduction to Spatial omics Sinem Saka EMBL Heidelberg GermanyCourtyard Room A B15 15 16 15Student flash talksCourtyard Room A B16 15 16 30Coffee breakCourtyard Foyer16 30 17 152D and 3D multiplexed imaging using IBEXAndrea Radtke Leica Microsystems and Colin Chu University of College LondonCourtyard Room A B17 15 18 45Tissue sample preparationEMBL Main building18 45 19 30Sample staining for multiplexed antibody imaging IBEX block stainEMBL Main building19 30 19 40Bus from EMBL to ISG hotelATC Entrance19 45 20 45Dinner at ISG hotelISG hotel Day 2 Monday 16 June 2025 Time Berlin Europe SpeakerLocation08 40 08 50Bus from ISG hotel to EMBL08 50 09 00Overview of the dayCourtyard Room A B09 00 09 45Sample staining for multiplexed antibody imaging IBEX wash mount continued Training Lab A B09 45 10 00Coffee breakCourtyard Foyer10 00 11 00Participant presentations I 1 4 Courtyard Room A B11 00 12 00Microscopy Sample Imaging IBEX microscopy cycle 1Microscopy rooms Imaging Centre12 00 13 00Lunch at EMBL CanteenEMBL Canteen13 00 14 00Participant presentations II 5 8 Courtyard Room A B14 00 15 00Sample staining for multiplexed antibody imaging IBEX bleach restain continued Training Lab A B15 00 15 15Coffee breakCourtyard Foyer15 15 16 00Immuno SABER intro and sample preparationTraining Lab A B16 00 16 45Generation of concatemeric signal amplifiersTraining Lab A B16 45 18 45Antibody DNA conjugation With flexible coffee breakTraining Lab A B18 45 19 30Sample staining for multiplexed antibody imaging SABER stain continued Training Lab A B19 30 20 30Pizza dinnerATC Rooftop Lounge20 30 20 40Bus from EMBL to ISG hotel Day 3 Tuesday 17 June 2025 Time Berlin Europe SpeakerLocation08 35 08 45Bus from ISG hotel to EMBL08 45 09 00Overview of the dayCourtyard Room A B09 00 10 15Sample staining for multiplexed antibody imaging SABER wash and concatemer hyb continued Training Lab A B10 15 10 30Coffee break10 30 11 30Participant presentations III 9 12 Courtyard Room A B11 30 12 15Sample staining for multiplexed antibody imaging SABER wash and imager hyb continued Training Lab A B12 15 12 30Group photo 12 30 13 15Lunch at EMBL CanteenEMBL Canteen13 15 15 15Microscopy Sample Imaging Wash mount SABER imaging and restainTraining Lab A B15 15 15 30Coffee break15 30 16 30Participant presentations IV 13 16 Courtyard Room A B16 30 17 30Microscopy Sample Imaging Wash and SABER imagingTraining Lab A B17 30 18 45Oligo padlock probe design ISS intro and probe design With flexible coffee breakTraining Lab A B18 45 19 45In situ sequencing ISS hyb padlockTraining Lab A B19 45 20 45Dinner at EMBL CanteenEMBL Canteen20 45 20 50Bus from EMBL to ISG hotelATC Entrance Day 4 Wednesday 18 June 2025 Time Berlin Europe SpeakerLocation08 40 08 50Bus from ISG hotel to EMBL 08 50 09 00Overview of the dayCourtyard Room A B09 00 10 00In situ sequencing ISS ligation continued Training Lab A B10 00 10 15Coffee breakCourtyard Foyer10 15 11 00Imaging metabolic regulation in human cancerFelix Hartman DKFZ GermanyCourtyard Room A B11 00 12 00In situ sequencing ISS RCA continued Training Lab A B12 00 13 00Lunch at EMBL CanteenEMBL Canteen13 00 13 45Image and data analysis of spatial transcriptomics Marco Grillo Stockholm University SwedenCourtyard Room A B13 45 14 30Mapping cells in space and time Omer Bayraktar Sanger Institute UKVirtual talkCourtyard Room A B14 30 15 00Coffee break Courtyard Foyer15 00 15 40Principles of data management for spatial omics Caterina Strambio De Castillia University of Massachusetts USA Virtual talkCourtyard Room A B15 40 16 10Data frameworks and analysis tools for spatial omics Oliver Stegle EMBL HeidelbergCourtyard Room A B16 15 17 00Bus to city centre with a stop at ISG hotel 17 00 19 15Heidelberg city walking tour and Free time 19 15 21 30Downtown course dinner Day 5 Thursday 19 June 2025 Time Berlin Europe SpeakerLocation09 40 09 50Bus from ISG hotel to EMBL09 50 10 00Overview of the dayCourtyard Room A B10 00 11 00In situ sequencing ISS L probe continued Training Lab A B11 00 11 15Coffee breakCourtyard Foyer11 15 12 00Data analysis for spatial proteomicsDenis Schapiro Heidelberg University GermanyCourtyard Room A B12 00 13 00Lunch at EMBL CanteenEMBL Canteen13 00 14 00In situ sequencing ISS imager continued Training Lab A B14 00 15 00Round table discussion on pitfalls and challenges for the various methodsCourtyard Room A B15 00 15 15Coffee breakCourtyard Foyer15 15 16 30Microscopy Sample Imaging ISS microscopy continued Microscopy rooms16 30 18 00User case discussion with flexible coffee breakATC Rooftop Lounge18 00 19 00Multimodal in situ analysis of single cell transcriptional states Xiao Wang Broad Institute MIT and Harvard USA Virtual talkCourtyard Room A B19 00 20 00Dinner at EMBL CanteenEMBL Canteen20 00 20 10Bus from EMBL to ISG hotelATC Entrance Day 6 Friday 20 June 2025 Time Berlin Europe SpeakerLocation08 40 08 50Bus from ISG hotel to EMBL08 50 09 00Overview of the dayCourtyard Room A B09 00 10 00Data analysis exercises Data processingComputer Training Lab10 00 10 15Coffee breakCourtyard Foyer10 15 11 00Spatial proteomics Fabian Coscia Max Delbruck Center GermanyCourtyard Room A B11 00 12 00Data analysis exercises Visualisation I continued Computer Training Lab12 00 13 00Lunch at EMBL CanteenEMBL Canteen13 00 14 00Data analysis exercises Visualisation II continued Computer Training Lab14 00 14 30Final feedback and summaryCourtyard Room A B14 30 15 00Departure shuttle bus to Heidelberg train station ATC Entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission and all course materials Academia 500PhD Student 500Industry 1000 Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 1500 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 1500 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waivers The fee waiver will cover the registration sum that you have paid to attend the course Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 15 to 20 June 5 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 22 5 per night availability of single rooms may be limited This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course You will need admin rights to be able to install the software on your computer and we recommend you try this before the course If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Event partner Event sponsors Media partners Microcscopy and Analysis a Wiley journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Alvaro Crevenna, Andrea Radtke, Emerald Perlas, Sinem Saka,

14 June - 20 June 2025

Computational modelling of multicellular systems

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview Course overview This practical course teaches the basics of multicellular modelling to any researcher wishing to enter the field particularly experimentalists with no prior experience of computational modelling It is a hands on course with 60 of the time devoted to students working on laptops performing exercises designed to give a practical familiarity with different types of computational modelling The course focuses on the dynamics of multicellular systems from embryos to organoids covering both the molecular side how gene regulatory networks perform pattern formation and also the mechanical side in 2D and 3D how the movements and activities of many cells together leads to tissue level morphogenesis and organisation A carefully chosen variety of modelling tools will be introduced which cover the core approaches of vertex models finite element models FEM and agent based models ABM Attendees will also work through the week in small groups on group projects which will be presented on the last day to the whole class Each day will end with a keynote lecture by a prominent researcher in the field putting the topic of the day into context through an example of relevant biological research The week is organised to maximise networking between the students and the teachers and speakers This event has been granted the following EMBO sustainability badge Grade 1 of 3 Speakers Speakers trainers staff Katie Bentley The Francis Crick Institute UK James Briscoe The Francis Crick Institute UK Javier Buceta Institute for Integrative Systems Biology I SysBio CSIC UV Spain Jordi Garcia Ojalvo Universitat Pompeu Fabra Spain Yanlan Mao MRC Laboratory for Molecular Cell Biology UK James Sharpe EMBL Barcelona Spain Alejandro Torres Sanchez EMBL Barcelona Spain Berta Verd University of Oxford UK Alexandria Volkening Purdue University USA Scientific organisers Katie Bentley The Francis Crick Institute UK James Sharpe EMBL Barcelona Spain Alejandro Torres Sanchez EMBL Barcelona Spain Event organisers Silvia Autet Balcells Operations Officer EMBL Barcelona Spain Regie Jimena de la Pena Trainee EMBL Barcelona Spain Julia Patricia Nohle Course and Conference Officer EMBL Heidelberg Germany Programme This programme is subject to changes If you are sharing this meeting on social media please use the hashtag EMBOMulticellModelling and don t forget to tag EMBLEvents Day 1 Saturday 14 June 2025 Time Barcelona Europe SpeakerLocation14 00 15 00HousenotesCourse Overview and Meet Greet with welcome Drink nibbles15 00 15 45Bootcamp Lecture 1Why modelling biological systems Basic mathematical concepts that serve to quantify biological processesJames Sharpe EMBL Barcelona SpainSeminar Room Aula de Seminari 15 45 16 45Bootcamp Practical 1main trainer James Sharpe EMBL Barcelona Spain Practical exercises on laptops introduction to programming define a function plot it compute derivatives explore Hill functions Software python codeSeminar Room Aula de Seminari 16 45 17 15Coffee break17 15 18 00Bootcamp Lecture 2Dynamics of gene regulation through ordinary differential equations ODEs James Sharpe EMBL Barcelona SpainSeminar Room Aula de Seminari 18 00 19 00Bootcamp Practical 2Practical exercises on laptops Numerically solve ODEs and plot the solutions analyse gene regulatory network dynamics Software python code Seminar Room Aula de Seminari 19 00 21 00DinnerOffsite Day 2 Sunday 15 June 2025 Time Barcelona Europe SpeakerLocation08 50 09 00Daily Testing and Welcome overview of the day09 00 09 45Bootcamp Lecture 3 Qualitative interpretation of the dynamics of GRN Phase portraits fixed points and stabilityAlejandro Torres S nchez EMBL Barcelona SpainSeminar Room Aula de Seminari 09 45 10 45Bootcamp Practical 3main trainer Alejandro Torres S nchez EMBL Barcelona SpainPractical exercises on laptops Create phase portraits and detect fixed points in gene regulatory models Classify their stability Trajectories in phase space connection with previous day Software python code Seminar Room Aula de Seminari 10 45 11 15Coffee break11 15 12 00Bootcamp Lecture 4Bifurcations how phase portraits can qualitatively change leading to different biological behavioursAlejandro Torres S nchez EMBL Barcelona SpainSeminar Room Aula de Seminari 12 00 13 00Bootcamp Practical 4main trainer Alejandro Torres S nchez EMBL Barcelona SpainPractical exercises on laptops saddle node pitchfork bifurcations biological examples Software python code Seminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Bootcamp Lecture 5Modelling oscillations in gene expression Limit cycles Hopf bifurcations Jordi Garcia Ojalvo Universitat Pompeu Fabra SpainSeminar Room Aula de Seminari 14 45 15 45Bootcamp Practical 5main trainer Jordi Garcia Ojalvo Universitat Pompeu Fabra SpainPractical exercises on laptops Dynamics of gene regulation through ordinary differential equations ODEs Software python code Seminar Room Aula de Seminari 15 45 16 15Coffee break16 15 18 00Bootcamp debrief and discussionBreakout Area18 00Free evening Day 3 Monday 16 June 2025 Time Barcelona Europe SpeakerLocation08 50 09 00Daily Testing and Welcome overview of the day09 00 09 45Lecture 6 Spatial systems partial differential equations discretized continuum modelling of space diffusion different types of gradient formation interpretation of a gradient solving the French Flag Problem scale invariance positional information James Sharpe EMBL Barcelona SpainSeminar Room Aula de Seminari 09 45 10 45Practical 6main trainer James Sharpe EMBL Barcelona SpainPractical exercises on laptops Dynamics of gene regulation through ordinary differential equations ODEs Software LimbnetSeminar Room Aula de Seminari 10 45 11 15Coffee break11 15 12 00Lecture 7 Main classes of Turing pattern spots versus stripes boundary conditions creating a Pearson plot travelling waves versus stable patternsJames Sharpe EMBL Barcelona SpainSeminar Room Aula de Seminari 12 00 13 00Practical 7main trainer James Sharpe EMBL Barcelona SpainPractical exercises on laptops Dynamics of gene regulation through ordinary differential equations ODEs Software LimbnetSeminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Lecture 8 Controlling self organised patterns with positional information how gradients could alter wavelength in 1D how 2D gradients could alter the spatial patterns example of limb development Limitations of modelling what it can and cannot doJames Sharpe EMBL Barcelona SpainSeminar Room Aula de Seminari 14 45 15 45Practical 8main trainer James Sharpe EMBL Barcelona SpainPractical exercises on laptops Qualitative interpretation of the dynamics of GRN Phase portraits fixed points and stabilitySeminar Room Aula de Seminari 15 45 16 15Coffee break16 15 19 00Group project session IBreakout Area19 00 20 00Keynote I Using phase portraits to understand molecular pattern formationBerta Verd University of Oxford United KingdomSeminar Room Aula de Seminari 20 00 22 00DinnerOffsite Day 4 Tuesday 17 June 2025 Time Barcelona Europe SpeakerLocation09 00 09 45Lecture 9More complex spatial systems Drosophila gap gene patterns temporal integration Sonic hedgehog in the neural tube multiple gradientsJordi Garcia Ojalvo Universitat Pompeu Fabra SpainSeminar Room Aula de Seminari 09 45 10 45Practical 9main trainer Jordi Garcia Ojalvo 4 assistantsPractical exercises on laptops on Bifurcations how phase portraits can qualitatively change leading to different biological behavioursSoftware python code Seminar Room Aula de Seminari 10 45 11 15Coffee break11 15 12 00Lecture 10Understanding the sources and impact of noise in biological systems gene regulatory networksJordi Garcia Ojalvo Universitat Pompeu Fabra SpainSeminar Room Aula de Seminari 12 00 13 00Practical 10main trainer Jordi Garcia Ojalvo 4 assistantsPractical exercises on laptops on Modelling oscillations in gene expression Limit cycles Hopf bifurcationsSoftware python code Seminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Lecture 11Understanding the sources and impact of noise in biological systems spatial patterningJordi Garcia Ojalvo Universitat Pompeu Fabra SpainSeminar Room Aula de Seminari 14 45 15 45Practical 11main trainer Jordi Garcia Ojalvo 4 assistantsPractical exercises on laptops on Spatial systems partial differential equations discretized continuum modelling of space diffusion different types of gradient formation interpretation of a gradient solving the French Flag Problem scale invariance positional information Software python code Seminar Room Aula de Seminari 15 45 16 15Coffee break16 15 19 00Group project session IIBreakout Area19 00 20 00Keynote II Embryonic pattern formationJames Briscoe Francis Crick Institute United KingdomSeminar Room Aula de Seminari 20 00Free evening Day 5 Wednesday 18 June 2025 Time Barcelona Europe SpeakerLocation09 00 09 45Lecture 12Basics of agent based modelling ABM different types of agent interaction emergent behaviour in flocking The simplifying assumptions and possible pitfalls of the ABM approachAlexandria Volkening Purdue University USASeminar Room Aula de Seminari 09 45 10 45Practical 12main trainer Alexandria Volkening Purdue University USA 4 assistants Practical exercises on laptops on the topics of lecture 13 listed above Software NetLogo online Seminar Room Aula de Seminari 10 45 11 15Coffee break11 15 12 00Lecture 13Modelling pattern formation in an agent based model diffusion gene regulation networks and feedback on morphogenesisKatie Bentley Francis Crick Institute UKSeminar Room Aula de Seminari 12 00 13 00Practical 13main trainer Katie Bentley Francis Crick Institute UK 4 assistants Practical exercises on laptops on the topics of lecture 14 listed above Software NetLogo online Seminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Lecture 14Modelling complex tissues stripe formation in zebrafishAlexandria Volkening Purdue University USASeminar Room Aula de Seminari 14 45 15 45Practical 14main trainer Alexandria Volkening Purdue University USA 4 assistants Practical exercises on laptops on the topics of lecture 15 listed above Software NetLogo online Seminar Room Aula de Seminari 15 45 16 15Coffee break16 15 18 15Flash talksBreakout Area18 15 19 00Networking and Meet the speakersBreakout Area19 00 20 00Keynote III Using Agent based Models to explain vasculogenesisKatie Bentley Francis Crick Institute UKSeminar Room Aula de Seminari 20 00 22 00DinnerOffsite Day 6 Thursday 19 June 2025 Time Barcelona Europe SpeakerLocation09 00 09 45Lecture 15Combining molecules with mechanics molecular patterning in vertex models using molecular patterns to control growth morphogenesis boundary sharpening combining signalling and cell behaviourJavier Buceta I SysBio CSIC UV SpainSeminar Room Aula de Seminari 09 45 10 45Practical 15main trainer Javier Buceta I SysBio CSIC UV Spain 4 assistants Practical exercises on laptops on the topics of lecture 7 listed above Software ChasteSeminar Room Aula de Seminari 10 45 11 15Coffee break11 15 12 00Lecture 16Morphogenesis anisotropic growth intercalation T1 2 3 transitions planar polarityJavier Buceta I SysBio CSIC UV SpainSeminar Room Aula de Seminari 12 00 13 00Practical 16main trainer Javier Buceta I SysBio CSIC UV Spain 4 assistants Practical exercises on laptops on the topics of lecture 8 listed above Software ChasteSeminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Lecture 17Combining molecules with mechanics molecular patterning in vertex models using molecular patterns to control growth morphogenesis boundary sharpening combining signalling and cell behaviourJavier Buceta I SysBio CSIC UV SpainSeminar Room Aula de Seminari 14 45 15 45Practical 17main trainer Javier Buceta I SysBio CSIC UV Spain 4 assistants Practical exercises on laptops on the topics of lecture 9 listed above Software ChasteSeminar Room Aula de Seminari 15 45 16 15Coffee break16 15 19 00Group project session IIIBreakout Area19 00 20 00Keynote IV Vertex modelling to explain epithelial developmentAlex Fletcher University of Sheffield UKSeminar Room Aula de Seminari 20 00Free evening Day 7 Friday 20 June 2025 Time Barcelona Europe SpeakerLocation09 00 09 45Lecture 18The basics and maths of continuum mechanics force vectors and stress tensors etc linear elasticity and the stokes equations basic example of non uniform growthAlejandro Torres Sanchez EMBL Barcelona SpainSeminar Room Aula de Seminari 09 45 10 45Practical 18main trainer Alejandro Torres S nchez EMBL Barcelona SpainPractical exercises on laptops on the topics of lecture 10 listed above Software hiperlife Seminar Room Aula de Seminari 10 45 11 15Coffee break11 15 12 00Lecture 19Defining tissue geometries manual creation of geometries meshes segmentation of tissue geometry from image data triangulation tetrahedralization solving basic equationsAlejandro Torres Sanchez EMBL Barcelona SpainSeminar Room Aula de Seminari 12 00 13 00Practical 19main trainer Alejandro Torres S nchez EMBL Barcelona SpainPractical exercises on laptops on the topics of lecture 11 listed above Software hiperlifeSeminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Lecture 20Combining molecules with mechanics molecular diffusion in FEM simple example of feedback between molecular gradient and morphogenesisAlejandro Torres Sanchez EMBL Barcelona SpainSeminar Room Aula de Seminari 14 45 15 45Practical 20main trainer Alejandro Torres S nchez EMBL Barcelona SpainPractical exercises on laptops on the topics of lecture 12 listed above Software hiperlifeSeminar Room Aula de Seminari 15 45 16 15Coffee break16 15 17 15Keynote V Using FEM to model how non uniform proliferation rates lead to controlled buckling and bending of wing disc epitheliumYanlan Mao University College London UKSeminar Room Aula de Seminari 17 15 18 45Group project presentationsSeminar Room Aula de Seminari 18 45 19 45Wrap up discussion and course debrief19 45 21 45DinnerOffsite Practical Information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the hotel to the venue Academia 550PhD Student 550Industry 1100 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses and Workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at a nearby hotel for the default dates of 14 June to 21 June 2025 7 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfast Local transport The hotel is just a few minutes from the Collaboratorium space where the practical course will be held Further details The address of the hotel will be communicated later in the process Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors This course is supported by the Theory EMBL research programme which promotes theory guided paths to discovering understanding and conceptualising the underlying principles of complex and dynamic biological systems Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Katie Bentley, James Sharpe, Alejandro Torres-Sanchez

11 June 2025

A FAIR and scalable workflow for plankton phenogenomics at single cell level

Description High throughput single cell approaches have become increasingly applied in marine sciences Predominantly separated between single cell sequencing or single cell imaging the next frontier aims at connecting both generating complex data architecture to link environmental data with single cell images and sequences In this webinar we will share our ongoing initiative to generate a scalable and FAIR workflow to both visualise and sequence symbiosis in phytoplankton Please note this webinar does not include a recording or presentation slides for later access...

10 June - 13 June 2025

The ageing genome: from mechanisms to disease

Description OverviewSpeakersProgrammePractical InformationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Ageing is often considered a complex phenotype that affects multiple organs and tissues in a time dependent manner This may result in the aged population consuming a myriad of medications each aimed to treat but not cure the affected tissue Recent studies have demonstrated that the Primary Hallmarks of Ageing are a set of five molecular mechanisms that malfunction independent of tissue type and drive ageing Hence focusing on these five hallmarks simplifies the efforts to understand ageing associated disease The second edition of this symposium will bring together an all new international line up of speakers to continue the exchange on the basic mechanistic aspects of chromosome biology with the applied and emerging field of ageing sciences As more and more interventions and supplements flood the market claiming to attenuate aging processes it is critical that we investigate genomic changes during the ageing process To keep the symposium fresh in 2025 there will be new emphasis on the importance of chromatin changes and telomere dysfunction nonetheless keeping in mind how they also affect DNA damage and repair responses This symposium will bring together many diverse fields across topics including the below and tie them together with the field of ageing biology and its relevant models of ageing Topics Endogenous and metabolic genotoxins Aneuploidy Loss of proteostasis Telomere dysfunction Age related disease Model systems for ageing research Senescence responses Chromatin stability and epigenetics Mitochondrial stability as a function of ageing DNA repair during the ageing process What past participants say about the conference This conference was very well organized great talks and exciting new tools and techniques were presented I am very happy I attended Highly recommend for everybody interested in microscopy Alina Gavrilov Hoffmann La Roche Speakers Keynote Speakers Eva Hoffmann University of Copenhagen Denmark Joachim Lingner EPFL Switzerland Speakers Simon Boulton The Francis Crick Institute UK Daphne Cabianca Helmholtz Munich Germany Ross Chapman University of Oxford UK Eiji Hara Osaka University Japan Andrew Jackson The University of Edinburgh UK Ga lle Legube Paul Sabatier University France Rong Li National University of Singapore Singapore Scott Lowe Memorial Sloan Kettering Cancer Center USA Thi Hoang Duong Kelly Nguyen MRC Laboratory of Molecular Biology UK Serena Nik Zainal University of Cambridge UK Patricia Opresko University of Pittsburgh USA Bjoern Schwer University of California San Francisco USA John Sedivy Brown University USA Julian Stingele Ludwig Maximilian University of Munich Germany Scientific organisers George Garinis Institute of Molecular Biology Biotechnology Greece Jacqueline Jacobs Netherlands Cancer Institute The Netherlands Bj rn Schumacher University of Cologne Germany Agnel Sfeir Sloan Kettering Institute MSKCC USA Conference Organiser Sophie Dutzi EMBL Heidelberg Germany Programme Are you on social media Post using EESAgeing and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 10 June 2025 Time Europe Berlin Session11 45 13 15Registration and light refreshments13 15 13 30Opening remarks13 30 14 30Keynote lecture Close encounters between telomeres and TERRA long noncoding RNAJoachim Lingner EPFL Switzerland14 30 17 30Session 1Session Chair Agnel Sfeir Sloan Kettering Institute MSKCC USA14 30 15 00SLFN11 restricts escape from replicative crisis to prevent ALTSimon Boulton The Francis Crick Institute UKNot available on demand15 00 15 15Loss of centromere identity in quiescent cells is a mechanism of mosaic loss of the Y chromosomeDaniele Fachinetti Institut Curie FranceNot available on demand15 15 15 30Rapamycin attenuates the lifespan extending effect of dietary restriction in premature aging nucleotide excision repair mutant mouse modelsJoris Demmers University of Cologne Germany15 30 16 00Coffee Break and meet the speakers16 00 16 303D genome under stress how environmental inputs influence nuclear organizationDaphne Cabianca Helmholtz Munich GermanyNot available on demand16 30 16 45DNA lesion bypass and the stochastic dynamics of transcription coupled repairMichael Nicholson University of Edinburgh UK16 45 17 00Reversion of aging chromatin profiles through FOXM1 mediated repression of the AP 1 complexFabio Ferreira i3S Institute for Research and Innovation in Health University of Porto Portugal17 00 17 30DNA double strand break repair in healthy ageing and tumour suppressionRoss Chapman University of Oxford UKNot available on demand17 30 17 45ZC3H4 preserves genome integrity and prevents cell senescence by mitigating transcription replication conflicts at non coding RNA lociYann Frey Tel Aviv University Israel17 45 18 00Comprehensive whole genome sequencing reveals origins of mutational signatures associated with aging mismatch repair deficiency and temozolomide chemotherapy focus on translesion polymerasesAnton Gartner Center for Genomic Integrity Institute for Basic Science Ulsan National Institute of Science and Technology UNIST Republic of Korea18 00 19 30Canteen dinner19 30 21 00After dinner drinks in ATC Rooftop lounge Day 2 Wednesday 11 June 2025 Time Europe Berlin Session09 00 12 00Session 2Session Chair Brian Luke Johannes Gutenberg University Institute of Molecular Biology Germany09 00 09 30Exploring the roles and mechanisms of cellular senescence in aging and cancer the microbial connectionEiji Hara Osaka University JapanNot available on demand09 30 09 45Premature progerin driven aging promotes G quadruplex DNA breakageRobert H nsel Hertsch Center for Molecular Medicine Cologne GermanyNot available on demand09 45 10 00Metabolite induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis Ashley Kamimae Lanning MRC Weatherall Institute of Molecular Medicine University of Oxford UK10 00 10 30Extreme growth disorders and ageingAndrew Jackson The University of Edinburgh UKNot available on demand10 30 11 00Coffee Break and meet the speakers11 00 11 30Transcriptional repression accounts for RNA DNA hybrid accumulation at DNA double strand breaksGa lle Legube Paul Sabatier University FranceNot available on demand11 30 11 45Untangling the genome maintenance functions of BRCA1 during unperturbed cell cycleJustine Sitz University of Copenhagen Denmark11 45 12 00Investigating the role of EP300 in chromosomally unstable breast cancerDani lle Koot European Research Institute for the Biology of Ageing University Medical Center Groningen The Netherlands12 00 12 30Flash talk session 40 Aguilar Mario 41 Aksianiuk Valeryia 50 Galanos Panos 65 Levy Tomer 66 Li Xuanjing 68 Louzada Neto Orlando 75 Muralidharan Chandramouli 78 Patel Tushar 82 Saroj Neha 84 Shiomi Akifumi 86 Stojanovic Stevan 92 Watase Joji George 12 30 14 00Lunch and meet the editors14 00 16 00Poster Session 1 odd numbers 16 00 17 00Session 3Session Chair Ga lle Legube Paul Sabatier University France16 00 16 30Cytoplasmic mechanics aging and rejuvenation of mammalian oocytesRong Li National University of Singapore SingaporeNot available on demand16 30 16 45Targeting cGAS STING for the treatment of genomic instability driven pathologiesMario L pez Prieto Centro Nacional de Investigaciones Oncol gicas Spain16 45 17 00Epigenetic reprogramming via HDAC9 in premature aging associated lung inflammationEdibe Avci Justus Liebig Universit t Gie en Germany17 00Free evening Day 3 Thursday 12 June 2025 Time Europe Berlin Session09 00 12 00Session 4Session Chair Jacqueline Jacobs Netherlands Cancer Institute The Netherlands09 00 09 30Targeting senescent cell states in cancer and agingScott Lowe Memorial Sloan Kettering Cancer Center USA09 30 09 45Exploring endogenous damage in cockayne syndrome insights from neuronal cell cultureGabrielly Martins University of S o Paulo Brazil09 45 10 00Interplay between aging and ALS a new epigenetic perspectiveMarta Marzullo Sapienza University of Rome Italy10 00 10 30Replenishing the ends structural mechanism of human telomeraseThi Hoang Duong Kelly Nguyen MRC Laboratory of Molecular Biology UK10 30 11 00Coffee Break and meet the speakers11 00 11 30Benign and malignant mutational processes and implications in medicineSerena Nik Zainal University of Cambridge UKNot available on demand11 30 11 45Cryo EM analyses of xeroderma pigmentosum group E protein in nucleosomesSyota Matsumoto The University of Tokyo Japan11 45 12 00Neuron type specific aging rate reveals age decelerating interventions preventing neurodegenerationDavid Meyer University of Cologne Germany12 00 13 30Lunch 13 30 16 30Session 5Session Chair George Garinis Institute ofMolecular Biology Biotechnology Greece13 30 14 00Roles for oxidative telomere damage in cellular senescencePatricia Opresko University of Pittsburgh USA14 00 14 15An RNAse H exchange at telomeres controls R loops and rates of replicative senescenceBrian Luke Johannes Gutenberg University Institute of Molecular Biology Germany14 15 14 30The mutational footprint of DNA replicationBenjamin Schuster Boeckler University of Oxford UK14 30 15 00Implications of neuronal DNA damage for brain agingBjoern Schwer University of California San Francisco USANot available on demand15 00 15 30Coffee Break and meet the speakers15 30 16 00Exploring the dark genome somatic retrotransposition in cellular senescence and agingJohn Sedivy Brown University USAVVirtual talk16 00 16 15Distinct roles of RECQL5 in RAD51 mediated fork reversal and transcription elongationTarun Nagraj K G Indian Institute of Science IndiaNot available on demand16 15 16 30Immune aging the role of BAF chromatin remodeling complexes in the development and maintenance of regulatory T cellsKarolina Romaniuk University Medical Center of the Johannes Gutenberg University Institute of Molecular Biology IMB Germany16 30 18 30Poster Session 2 even numbers 18 30 20 00Conference dinner in the canteen20 00 20 30After dinner drinks20 30 23 00Conference Party Day 4 Friday 13 June 2025 Time Europe Berlin Session09 00 12 30Session 6Session Chair Jacqueline Jacobs Netherlands Cancer Institute The Netherlands09 00 09 30RNF25 confers mRNA damage tolerance by curbing activation of the integrated stress responseJulian Stingele Ludwig Maximilians Universit t M nchen GermanyNot available on demand09 30 09 45Transcription stress at telomeres leads to cytosolic DNA release and paracrine senescenceAthanasios Siametis Foundation for Research and Technology Hellas University of Crete Greece09 45 10 00mTOR inhibition attenuates DNA damage and immune cell senescence in humansLoren Kell University of Oxford UK10 00 10 30Coffee Break and meet the speakers10 30 10 45Post transcriptional regulation in DNA Damage response CPB 3 and ALG 2 control apoptosis in C elegansChristina Efraimoglou University of Cologne Germany10 45 11 45Keynote lectureGenomic ageing in the human germline from reproductive health to congenital disordersEva Hoffmann University of Copenhagen Denmark11 45 12 00Closing Remarks and Poster Prize Announcements12 00 12 30Packed lunch and departure Practical Information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editor 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Sophie for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Friday 9 May 2025 in some cases at special rates Please email the hotel directly quoting the booking code EES25 05 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg City ZentrumB B HotelISG Hotel Staycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Hilton Heidelberg Kurf rsten Anlage 1 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen Sie How are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page Sponsors Bronze Sponsor Event supporter Event Sponsor Dunn Labortechnik GmbH Ephyra Publishing journal NIA Aging Cell Repository Coriell Institute for Medical Research Media partners Advanced Biology a Wiley journal Advanced Genetics a Wiley journal Ageing and Cancer Research Treatment ACRT a Science Exploration Press journal BioEssays a Wiley journal Cancer Drug Resistance an OAE Publishing Inc journal ChemBioChem a Wiley journal Disease Models Mechanisms The Company of Biologists journal Genes and Development a Cold Spring Harbor journal Genome Research a Cold Spring Harbor journal Geromedicine a Science Exploration Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Systems Aging an Ephyra Publishing journal The EMBO Journal an EMBO Press journal The FEBS Journal a FEBS Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1350 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

George Garinis, Jaqueline Jacobs, Björn Schumacher, Agnel Sfeir

5 June 2025

From sequences to structures: Protein characterisation using EMBL-EBI APIs

Description Proteins are fundamental to biological processes and understanding their sequence structure and function is crucial for various applications in research This one day hands on virtual workshop will guide participants through a structured programmatic workflow using EMBL EBI resources Participants will learn how to retrieve protein sequences identify homologs annotate functional domains and explore structural information using REST APIs The course emphasises programmatic access APIs to integrate sequence functional and structural data into a unified analysis pipeline Through a step by step Python workflow participants will apply different EMBL EBI tools to analyse an example protein gaining practical experience in automating large scale protein data analysis Virtual courseThis course will take place on Zoom Trainers will be available to assist during practical sessions answer questions and provide further explanations during the Zoom To join the course you will need to create an EMBL EBI Training website account...

Barbara Etzi

4 June 2025

Data management in a bioimage informatics data flow

Description Making image data and their analysis output public aims at supporting transparency auditability and reproducibility of a research project However crucial contextual information is often lost along the way between image acquisition and publication resulting in a dramatic loss of value of the published data In this webinar we will follow the flow of bioimage data from acquisition to analysis focusing on data management practices in an open science context We will review points to consider and provide tips and examples for managing bioimage data and their metadata through a project s life...

3 June - 6 June 2025

25th international meeting of the European Light Microscopy Initiative

Description OverviewSpeakersProgrammeCommunity Room workshopsIndustry workshopsExhibitionSponsorshipPractical informationFootball match Academy vs IndustryMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please note this event is fully booked and registration for on site participation is now closed Please note that registration on site at the venue will not be available Thank you for your understanding Conference overview Founded in 2001 the European Light Microscopy Initiative ELMI was established to create a pivotal communication network among European scientists involved in light microscopy and equipment manufacturers Its primary goals are to advocate for light microscopy as an essential research tool in the life sciences and to enhance communication among researchers core facilities and the industry The 2025 edition of the European Light Microscopy Initiative conference sees a return to the European Molecular Biology Laboratory EMBL in Heidelberg for the first time since 2010 With EMBL s tradition of excellence in light microscopy this event promises to be a highly interactive and engaging experience making full use of the purpose built Advanced Training Centre venue and the EMBL Imaging Centre Highlights of the 2025 conference will include traditional company workshops an international line up of speakers a comprehensive exhibition and a dedicated community workshop room where participants can engage directly with experts and peers These sessions are specifically designed to facilitate learning collaboration and innovation among attendees from across the microscopy community Session topics Probes and biosensors Smart Advanced microscopy Super resolution microscopy Tissue imaging Lightsheet Imaging for health Data analysis Speakers Keynote speaker Elizabeth M C Hillman St Jude Children s Research Hospital USA Speakers Kazuhiro Aoki Kyoto University Japan Francesco Cardarelli Scuola Normale Superiore Italy Ali Ert rk LMU Munich Helmholtz Munich Germany Jacky Goetz Centre de Recherche en Biom decine de Strasbourg France Estibaliz G mez de Mariscal Instituto de Tecnologia Qu mica e Biol gica Ant nio Xavier ITQB NOVA Portugal Virginie Hamel University of Geneva Switzerland Mark Mc Caughrean Max Planck Institute for Astronomy Germany Siegfried Musser Texas A M University USA Maddy Parsons King s College London UK Robert Prevedel EMBL Heidelberg Germany Lin Tian Max Planck Florida Institute for Neuroscience USA Martin Weigert TU Dresden Germany Venera Weinhardt Heidelberg University Germany Scientific organisers Elisa D Este Max Planck Institute for Medical Research Germany Ulrike Engel Heidelberg University Germany Elisa May German Cancer Research Center DKFZ Heidelberg Germany Rainer Pepperkok EMBL Heidelberg Germany Stefan Terjung EMBL Heidelberg Germany Timo Zimmermann EMBL Heidelberg Germany Organising committee members Karin Aumayr Institute of Molecular Pathology Austria Johanna Bischof EMBL Heidelberg Germany Francesca Cella University of Pisa Italy Julien Colombelli IRB Barcelona Spain Orestis Faklaris MRI CRBM France Joachim Goedhart University of Amsterdam The Netherlands Manuel Gunkel EMBL Heidelberg Germany Gabriel Krens Institute of Science and Technology Austria Austria Vibor Laketa Heidelberg University Germany Beate Faba Neumann EMBL Heidelberg Germany Yara Reis EMBL Heidelberg Germany Paula Sampaio Institute for Research and Innovation in Health i3S Portugal Damien Schapman University of Rouen France Britta Schroth Diez Max Planck Institute of Molecular Cell Biology and Genetics Germany Caterina Strambio UMass Medical School USA Conference organiser Aline Schnieder EMBL Heidelberg Germany Programme Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here Please find the conference bus schedule here Day 1 Tuesday 3 June 2025 Time Europe Berlin Speaker08 00 09 30Registration and Welcome coffeeRegistration is kindly sponsored by Becker Hickl09 30 09 45Welcome session Core Facility Day09 45 11 00Session 1 Quality controlSession chairs Orestis Faklaris Britta Schroth DiezNot available on demand11 00 11 30Coffee Break and exhibition11 30 11 45Session 2 Tool updateSession chairs Manuel Gunkel Gabriel KrensNot available on demand11 45 13 00Session 3 Data managementSession chairs Johanna Bischof Caterina StrambioNot available on demand13 00 13 50Lunch and exhibition13 50 14 00Preliminary results questionnaire Stress and conflict management in core facilities Sebastian Munck14 00 15 15Session 4 Career pathsElisa D Este Yara Reis Stefan TerjungNot available on demand15 30 16 00Bus transfer to football field for participants of football matchConcurrent coffee break and exhibition16 00 17 00Sports event Kick or danceFootball match at football field Boxberg or dance workshop in front of the ATCConcurrent coffee break and exhibition17 15 18 20Bus transfer to EMBL ATC for participants of football matchConcurrent coffee break and exhibition18 20 18 30Welcome session 25th international meeting of the European Light Microscopy Initiative18 30 19 30Keynote lecture What can we do with high speed 3D microscopy Elizabeth Hillman St Jude Children s Hospital Columbia University USANot available on demand19 30 20 0025 years of ELMI retrospectiveRainer Pepperkok EMBL Heidelberg GermanyTimo Zimmermann EMBL Heidelberg Germany20 00 21 30Dinner in EMBL Canteen21 30 22 45Pub quiz in EMBL Canteen Day 2 Wednesday 4 June 2025 Time Europe Berlin Speaker09 00 10 45Session 1 Probes and biosensorsSession chair Joachim Goedhart University of Amsterdam The Netherlands09 00 09 30Development of genetically encoded biosensors tools for understanding cell cycleKazuhiro Aoki Kyoto University Japan09 30 09 45Developing synthetic fluorescent probes for plant cells navigating the mazeMaarten Besten Wageningen University and Research The Netherlands09 45 10 00Genetically encoded biosensors for real time visualization of STAT activation in live cellsThi Nguyen University of Zurich Switzerland10 00 10 30Sensitive genetically engineered sensors for tracking a broad spectrum of physiological dopamine signaling Lin Tian Max Planck Florida Institute for Neuroscience USANot available on demand10 30 10 45Open access to imaging excellence and opportunities for Imaging Core Facility staff updates from Euro BioImaging and Global BioImagingJohanna Bischof Euro BioImaging ERIC Germany10 45 11 15Coffee break and exhibition11 15 13 00Session 2 Smart Advanced microscopySession chair Paula Sampaio Institute for Research and Innovation in Health i3S Portugal11 15 11 45Imaging dynamics and mechanics in cancerMaddy Parsons King s College London UKNot available on demand11 45 12 00Removing barriers to advanced imaging and machine learning based analysisJodie Malcolm University of York United Kingdom12 00 12 15Multiscale light field microscopy platform for multi purpose dynamic volumetric bioimagingYangyang Bai University of Southern California USA12 15 12 45Enhanced resolution and throughput in imaging of single cell anatomy by Soft X ray TomographyVenera Weinhardt Heidelberg University Germany12 45 13 00Leveraging hyperspectral electron microscopy towards data driven segmentation of cellular ultrastructureBen Giepmans University Medical Center Groningen The Netherlands13 00 13 15Global BioImage Analysts Society GloBIASPaula Sampaio Institute for Research and Innovation in Health i3S Portugal13 15 14 30Lunch and exhibition14 30 15 30Workshop 115 30 15 50Coffee Break and exhibition15 50 16 50Workshop 216 50 17 10Coffee Break and exhibition17 10 18 10Workshop 318 10 18 20Comfort break18 20 19 05The James Webb Space Telescope a revolution in astronomyMark McCaughrean Max Planck Institute for Astronomy Germany19 05 20 00Dinner in ATC Foyer20 00 22 00Poster Session 1 odd numbers Concurrent continued dinner in ATC Foyer until 20 3022 00 22 30Networking drinks Day 3 Thursday 5 June 2025 Time Europe Berlin Speaker09 00 10 45Session 3 Super resolution microscopySession chair Elisa D Este Max Planck Institute for Medical Research Germany09 00 09 30Unveiling the molecular architecture of the cell using expansion microscopyVirginie Hamel University of Geneva Switzerland09 30 09 45Transient dark states in cryo fluorescence microscopy and their potential role in super resolution microscopyTimo Zimmermann EMBL Heidelberg Germany09 45 10 00High resolution live cell imaging Structured Illumination Microscopy on Spinning Disk microscope via precise synchronizationVolodymyr Cherkas Institute of Bioorganic Chemistry PAS Poland10 00 10 30Overlapping nuclear import and export paths unveiled by two color MINFLUXSiegfried Musser Texas A M University USA10 30 10 45Single molecule imaging of structure and dynamics in transcription condensatesJan Hendrik Spille University of Illinois Chicago USANot available on demand10 45 11 15Coffee break and exhibitionkindly sponsored by Physik Instrumente11 15 13 00Session 4 Tissue imaging LightsheetJulien Colombelli Institute for Research in Biomedicine Barcelona IRB Barcelona Spain11 15 11 45Looking deeper with microscopy pushing the optical imaging frontier in biologyRobert Prevedel EMBL Heidelberg Germany11 45 12 00An agarose fluidic chip for high throughput in toto organoid imagingSarah De Beuckeleer University of Antwerp BelgiumNot available on demand12 00 12 15The road to OME Zarr 1 0 A FAIR future for bioimagingJosh Moore German BioImaging e V Germany12 15 12 45Decoding diseases in 3D AI powered cell level imaging and omicsAli Ertuerk LMU Munich Helmholtz Munich Germany12 45 13 00Multi modal light sheet imaging of bacteria in Atlantic salmon skinJon Richard Sommernes UiT The Arctic University of Norway Norway13 00 14 30Lunch and exhibition14 30 15 30Workshop 415 30 15 50Coffee Break and exhibitionkindly sponsored by Physik Instrumente15 50 16 50Workshop 516 50 17 10Coffee break and exhibitionkindly sponsored by Physik Instrumente17 10 18 10Workshop 618 10 20 10Poster Session 2 even numbers 20 10 21 30Conference dinner in EMBL Canteen21 30 00 00Conference party with band and DJ Day 4 Friday 6 June 2025 Time Europe Berlin Speaker09 00 10 30Session 5 Imaging for healthSession chair Vibor Laketa Heidelberg University Hospital Germany09 00 09 30Once in a fluorescence lifetime from synthetic identity to biological function of nanoencapsulated drugs in biomedical applicationsFrancesco Cardarelli Scuola Normale Superiore Italy09 30 09 45Turbocharged 3D histology revolutionizing medical tissue analysis with automation light sheet microscopy and nanobodiesMichael Weber BIH Charit Germany09 45 10 00Large scale high content imaging for drug discovery across multiple labsChristopher Schmied Leibniz Forschungsinstitute f r Molekulare Pharmakologie FMP Germany10 00 10 30Tracking metastasis from the insideJacky Goetz INSERM U1109 Tumor Biomechanics Universit de Strasbourg France10 30 11 00Coffee break and exhibition11 00 12 30Session 6 Data analysisAnna Kreshuk EMBL Heidelberg Germany11 00 11 30Harnessing DL towards the limits of live microscopy imaging Estibaliz G mez de Mariscal Instituto de Tecnologia Qu mica e Biol gica Ant nio Xavier ITQB NOVA Portugal11 30 11 45Integrating Reproducible Image Analysis pipelines with OMEROMaarten Paul LUMC The Netherlands11 45 12 00Microscopy Nodes versatile and effective 3D rendering in BlenderOane Gros EMBL Heidelberg Germany12 00 12 30Martin Weigert TU Dresden Germany12 30 12 40Closing remarks12 40Packed lunch and departure This page is kindly sponsored by Community Room workshops ELMI Community Room abstract submission for workshop proposals The community room is a recent addition at ELMI meetings where participants can engage directly with experts and peers Sessions in the community room are specifically designed to facilitate learning collaboration and innovation among attendees from across the microscopy community In addition to the workshops we are planning to support spontaneous meetings in the community room and set them up separately more info on this will be provided at a later stage Workshop details The workshops will take place in parallel with the industry workshops on Wednesday 4 June and Thursday 5 June afternoon Two rooms are available for the workshops Each room can accommodate 8 10 participants A total of 12 workshop slots are available six per room Each workshop slot will be 1 hour long Each workshop facilitator has to be registered for the ELMI meeting Available equipment In each room one fully motorized wide field microscope with a scientific CMOS camera will be available Microscopes are kindly provided by Zeiss and Nikon The ELMI Community Room is organized by German BioImaging GMB e V www gerbi gmb de Euro BioImaging www eurobioimaging eu and QUAREP LiMi https quarep org For any questions or assistance with your abstract submission feel free to reach out via elmi community room gerbi gmb de We look forward to your submissions Day 2 Wednesday 4 June 2025 Workshop 1 14 30 15 30 Imaging workflows in OMEROPetr Walczysko University of Dundee OME Team Meeting Room 218 Imaging CentreEstimation of the Photon Conversion Factor Noise and Dynamic Range of Light Microscope Detection Systems QUAREP LiMi Valeria Berno San Raffaele Hospital Meeting room B11 Advanced Training Centre Workshop 2 15 50 16 50 Automatic power measurement and stability assessment for any microscope with SmartLPMArne Fallisch University of Freiburg Life Imaging Center Meeting Room 218Bioimaging data organization in OMEROChristian Schmidt DKFZ German Cancer Research Center Meeting Room B11 Workshop 3 17 10 18 10 Biomero orchestrating fair workflows in omeroLuik Torec Amsterdam UMC Meeting room B11 Advanced Training CentreMeasuring and monitoring the PSF of a microscopeIoannis Alexopoulos Justus Liebig University Giessen Meeting room 218 Imaging Centre Day 3 Thursday 5 June 2025 Workshop 4 14 30 15 30 Hands on REMBI compliant annotations in OMEROChristian Schmidt DKFZ German Cancer Research Center Meeting room 218 Imaging CentrePixelQuality best practices for publishing images QUAREP LiMi Christopher Schmied Leibniz Forschungsinstitut f r Molekulare Pharmakologie Meeting room B11 Advanced Training Centre Workshop 5 15 50 16 50 Why should Microscopists from Academia join the International Organization for Standardization ISO and how can they do it Roland Nitschke University of Freiburg Meeting room 218 Imaging CentreAutomated quality assessment of illumination and detection systems using the QUAREP LiMi tool kit WG1 WG2 Yann Cesbron Institute of Science and Technology Austria Meeting room B11 Advanced Training Centre Workshop 6 17 10 18 10 Increase recognition for your methods and your Core Facility with protocols ioEmma Ganley protocols io Springer Nature Meeting room B11 Advanced Training CentreFAIR 101 Navigating FAIR data from principles to practiceIsabel Kemmer Euro BioImaging Bio Hub EMBL Meeting room 218 Imaging Centre Industry workshops The company workshop sessions will take place on Wednesday June 4th and Thursday June 5th afternoons Across six time slots multiple engaging workshops will be offered featuring interactive sessions product demonstrations and in depth technical updates These workshops are a key part of ELMI s unique experience Participants will have the opportunity to register for individual workshops in advance The workshop abstracts will be listed on this page at the beginning of May After official registration closes a separate registration link will be sent to all confirmed participants As each workshop has a limited capacity we encourage you to select and sign up for your preferred sessions as soon as possible Day 2 Wednesday 4 June 2025 Workshop 1 14 30 15 30 Download Workshop 1 abstracts Multicolor TIRF Imaging with Abbelight s SAFe SystemAbbelight Microscopy room 116b Advanced Training CentreAbberior STED MINFLUX Workshop Biological Imaging Across ScalesAbberior Session A Seminar room 114 Imaging CentreAbberior MINFLUX Workshop 3D and 2 colour MINFLUX nanoscopyAbberior Session B Seminar room 162 Imaging CentreAffodable Modular Microscopes From ASIApplied Scientific Instrumentation ASI RTL Area B Advanced Training CentreLCS SPIM Light Sheet Microscopy for Large Cleared Samples in high resolutionBruker Luxendo GmbH Seminar room 104 Imaging CentreLightfield 4D Keeping pace with the pulse of life Carl Zeiss Courtyard Room A Advanced Training CentreUltra Large Field of View Imaging Using Innovative Photonic Chip TechnologyChip Nanoimaging Microscopy room 516 ALMF Building 13 Unlocking 3D Complexity Integrated Confocal and Super Resolution Microscopy for Organoid and Model Organism AnalysisCrest Optics Microscopy room 117a Advanced Training CentreUnlock the Dynamics of Life Experience High Speed Super Resolution Live Cell Imaging with the MI SIMCSR Biotech Microscopy room 116a Advanced Training CentreRaw image data what it really is and how to handle it at scaleDotphoton Main Auditorium incl livestream Advanced Training CentrePushing the limit of spinning disk confocal with the IXplore IX85 Evident FlexLab B Advanced Training CentreAdvancing 3D Spatial Omics with High Multiplex ImagingLeica Courtyard Room B Advanced Training CentreFast Label Free Live Cell Analysis with Digital Holographic MicroscopyLyncee Tech Microscopy room 117b Advanced Training CentreIntroducing the New Scanning Solution from Nikon Slide Scanning Made Easy Without Compromising on Image QualityNikon FlexLab A Advanced Training CentreAre you ready to begin your dSTORM journey An introduction to the Nanoimager and the ONI Training Kit dSTORMONI Seminar room 125 Imaging CentreUnlock the Potential of Microscopy Images with AI Enhanced Analysis in Imaris 10 2Oxford Instruments Meeting room B28 Advanced Training CentreUltra thin Light Sheet Microscopy Providing Multi user Experience Combined with Automated Multi scale Imaging CapabilitiesPhaseView Microscopy room 116c Advanced Training CentrePushing Boundaries in FLIM to Enhance Efficiency Quality and ReproducibilityPicoQuant Lecture Hall 103 Imaging CentreLeveraging Amira Software s AI capabilities for advanced image analysis and optical image segmentationThermo Fisher Scientific Helix B Advanced Training CentreHolotomography the next imaging breakthrough is unlabeledTomocube Helix A Advanced Training CentreVisiScope Confocal based on Yokogawa CSU W1 with Lumencor ZIVA 7 turn key Multimode Laser illuminationVisitron RTL Area A Advanced Training Centre Workshop 2 15 50 16 50 Download Workshop 2 abstracts High Throughput STORM Imaging with Abbelight s SAFe System Featuring ASTER Illumination Abbelight Microscopy room 116b Advanced Training CentreAbberior STED MINFLUX Workshop Biological Imaging Across ScalesAbberior Session A Seminar room 114 Imaging CentreAbberior MINFLUX Workshop 3D and 2 colour MINFLUX nanoscopyAbberior Session 5 Seminar room 162 Imaging CentreFast volumetric imaging with the ASI single objective light sheetApplied Scientific Instrumentation ASI RTL Area B Advanced Training CentreVutara VXL Volumetric and 3D Single Molecule Localization MicroscopyBruker Luxendo GmbH Seminar room 104 Imaging CentreUnlocking the Future of Imaging with ZEISS Lattice SIM 3Carl Zeiss Courtyard Room A Advanced Training CentreUltra Large Field of View Imaging Using Innovative Photonic Chip TechnologyChip Nanoimaging Microscopy room 516 ALMF Building 13 Lattice SIM across scales breaking the diffraction limit barrier in Z depth Crest Optics Microscopy room 117a Advanced Training CentreThe New Frontier of Super Resolution Label Free Meets SIM for Live Cell ImagingCSR Biotech Microscopy room 116a Advanced Training CentreBest in class S N ratio and acquisition speed for LSM FV4000 with SiLVIR DetectorEvident Scientific FlexLab B Advanced Training CentreTauSTED Xtend gentle nanoscopy to observe the dynamics of lifeLeica Room 15 042 Imaging CentreFast Label Free Live Cell Analysis with Digital Holographic MicroscopyLyncee Tech Microscopy room 117b Advanced Training CentreAutomated micropositioning Agility meets precisionM rzh user Wetzlar Main Auditorium incl livestream Advanced Training CentreAdvances in Automated imaging with Eclipse Ji and X Light V3Nikon FlexLab A Advanced Training CentreFrom Basics to brilliance Using the ONI Nanoimager with the Discovery Kit dSTORM in cells The ultimate kit to prepare your samples for super resolution with ease ONI Seminar room 125 Imaging CentreWhen Seeing Fails and Objective Lens Truths Prevail Linking Microscope Quality Control Metrics to More Precise Biological ReadoutsOxford Instruments Meeting room B28 Advanced Training CentreUltra thin Light Sheet Microscopy Providing Multi user Experience Combined with Automated Multi scale Imaging CapabilitiesPhaseView Microscopy room 116c Advanced Training CentrePerforming ISM FLIM with Luminosa s PDA 23 detection add onPicoQuant Lecture Hall 103 Imaging CentreAutomating Photomanipulation Experiments with RAPP OptoElectronic Devices Using Adaptive Feedback MicroscopyRapp Optics Microscopy room 512 ALMF Building 13 Leveraging Amira Software s AI capabilities for advanced image analysis and optical image segmentationThermo Fisher Scientific Helix B Advanced Training CentreHolotomography the next imaging breakthrough is unlabeledTomocube Helix A Advanced Training CentreVisiTIRF Orbital 110 ISO RingTIRF illumination with new Ultra Flat Homogenizer Technology Visitron RTL Area A Advanced Training Centre Workshop 3 17 10 18 10 Download Workshop 3 abstracts Multiplexed DNA PAINT Imaging with Abbelight s SAFe System in collaboration with Massive Photonics Abbelight Massive Photonics Microscopy room 116b Advanced Training CentreAbberior STED MINFLUX Workshop Biological Imaging Across ScalesAbberior Session A Seminar room 114 Imaging CentreAbberior MINFLUX Workshop 3D and 2 colour MINFLUX nanoscopyAbberior Session B Seminar room 162 Imaging CentreFast volumetric imaging with the ASI single objective light sheetApplied Scientific Instrumentation ASI RTL Area B Advanced Training CentreAcquifer HIVE Efficient image data workflows Connecting acquisition with centralized storage and processingBruker Luxendo GmbH Seminar room 104 Imaging CentreCairn Research Ltd Diamond Digital Micromirror Device Technology and ApplicationsCairn Research Main Auditorium incl livestream Advanced Training CentreLightfield 4D Keeping pace with the pulse of lifeCarl Zeiss Courtyard Room A Advanced Training CentreUltra Large Field of View Imaging Using Innovative Photonic Chip TechnologyChip Nanoimaging Microscopy room 516 ALMF Building 13 Multiplexed Confocal Imaging A High Throughput Approach to Deciphering Spatial OmicsCrest Optics Microscopy room 117a Advanced Training CentreMI SIM Advanced Mastering Intelligent Features for Super Resolution Live Cell ImagingCSR Biotech Microscopy room 116a Advanced Training CentrePushing the limit of spinning disk confocal with the IXplore IX85 Evident FlexLab B Advanced Training CentreViventis Deep Open top multi sample dual view light sheet microscope for live imaging of large multicellular systemsLeica Courtyard Room B Advanced Training CentreFast Label Free Live Cell Analysis with Digital Holographic MicroscopyLyncee Tech Microscopy room 117b Advanced Training CentreFrom samples to easy results with Artificial IntelligenceNikon FlexLab A Advanced Training CentreEverything Extra cellular Vesicles Harness the power of ONi super resolution expertise to characterise your EV s with easeONI Seminar room 125 Imaging CentreUnlock the Potential of Microscopy Images with AI Enhanced Analysis in Imaris 10 2Oxford Instruments Meeting room B28 Advanced Training CentreUltra thin Light Sheet Microscopy Providing Multi user Experience Combined with Automated Multi scale Imaging CapabilitiesPhaseView Microscopy room 116c Advanced Training CentreMonitoring of dynamic processes An easy and reliable way to perform single molecule FRET and FCS measurementsPicoQuant Lecture Hall 103 Imaging CentreLeveraging Amira Software s AI capabilities for advanced image analysis and optical image segmentationThermo Fisher Scientific Helix B Advanced Training CentreHolotomography the next imaging breakthrough is unlabeledTomocube Helix A Advanced Training CentreSmart Imaging Feedback Microscopy with VisiView SoftwareVisitron RTL Area A Advanced Training Centre Day 3 Thursday 5 June 2025 Workshop 4 14 30 15 30 Download Workshop 4 abstracts High Throughput STORM Imaging with Abbelight s SAFe System Featuring ASTER Illumination Abbelight Microscopy room 116b Advanced Training CentreAbberior STED MINFLUX Workshop Biological Imaging Across ScalesAbberior Session A Seminar room 114 Imaging CentreAbberior MINFLUX Workshop 3D and 2 colour MINFLUX nanoscopyAbberior Session B Seminar room 162 Imaging CentreLCS SPIM Light Sheet Microscopy for Large Cleared Samples in high resolutionBruker Luxendo GmbH Seminar room 104 Imaging CentreUnlocking the Future of Imaging with ZEISS Lattice SIM 3Carl Zeiss Courtyard Room A Advanced Training CentreUltra Large Field of View Imaging Using Innovative Photonic Chip TechnologyChip Nanoimaging Microscopy room 516 ALMF Building 13 Unlocking 3D Complexity Integrated Confocal and Super Resolution Microscopy for Organoid and Model Organism AnalysisCrest Optics Microscopy room 117a Advanced Training CentreUnlock the Dynamics of Life Experience High Speed Super Resolution Live Cell Imaging with the MI SIMCSR Biotech Microscopy room 116a Advanced Training CentrePushing the limit of spinning disk confocal with the IXplore IX85 Evident FlexLab B Advanced Training CentreAdvancing 3D Spatial Omics with High Multiplex ImagingLeica Courtyard Room B Advanced Training CentreFast Label Free Live Cell Analysis with Digital Holographic MicroscopyLyncee Tech Microscopy room 117b Advanced Training CentreIntegrated 3D Imaging Workflows From Sample Prep to Stunning Results with the UltraMicroscope PlatformMiltenyi RTL Area B Advanced Training CentreIntroducing the New Scanning Solution from Nikon Slide Scanning Made Easy Without Compromising on Image QualityNikon FlexLab A Advanced Training CentreAre you ready to begin your dSTORM journey An introduction to the Nanoimager and the ONI Training Kit dSTORMONI Seminar room 125 Imaging CentreWhen Seeing Fails and Objective Lens Truths Prevail Linking Microscope Quality Control Metrics to More Precise Biological ReadoutsOxford Instruments Meeting room B28 Advanced Training CentreUltra thin Light Sheet Microscopy Providing Multi user Experience Combined with Automated Multi scale Imaging CapabilitiesPhaseView Microscopy room 116c Advanced Training CentrePushing Boundaries in FLIM to Enhance Efficiency Quality and ReproducibilityPicoQuant Lecture Hall 103 Imaging CentreAutomating Photomanipulation Experiments with RAPP OptoElectronic Devices Using Adaptive Feedback MicroscopyRapp Optics Microscopy room 512 ALMF Building 13 Alignment Free Two Photon Microscopy with the Prelude SystemThorLabs Helix B Advanced Training CentreHolotomography the next imaging breakthrough is unlabeledTomocube Helix A Advanced Training CentreVisiScope Confocal based on Yokogawa CSU W1 with Lumencor ZIVA 7 turn key Multimode Laser illuminationVisitron RTL Area A Advanced Training Centre Workshop 5 15 50 16 50 Download Workshop 5 abstracts Multiplexed DNA PAINT Imaging with Abbelight s SAFe System in collaboration with Massive Photonics Abbelight Massive Photonics Microscopy room 116b Advanced Training CentreAbberior STED MINFLUX Workshop Biological Imaging Across ScalesAbberior Session A Seminar room 114 Imaging CentreAbberior MINFLUX Workshop 3D and 2 colour MINFLUX nanoscopyAbberior Session B Seminar room 162 Imaging CentreVutara VXL Volumetric and 3D Single Molecule Localization MicroscopyBruker Luxendo GmbH Seminar room 104 Imaging CentreLightfield 4D Keeping pace with the pulse of lifeCarl Zeiss Courtyard Room A Advanced Training CentreUltra Large Field of View Imaging Using Innovative Photonic Chip TechnologyChip Nanoimaging Microscopy room 516 ALMF Building 13 Lattice SIM across scales breaking the diffraction limit barrier in Z depth Crest Optics Microscopy room 117a Advanced Training CentreThe New Frontier of Super Resolution Label Free Meets SIM for Live Cell ImagingCSR Biotech Microscopy room 116a Advanced Training CentreHaving trouble imaging thick samples Come and learn the power of VS200 SILA speckle illumination Evident FlexLab B Advanced Training CentreLabware Cell Based Assaysibidi Main Auditorium incl livestream Advanced Training CentreTauSTED Xtend gentle nanoscopy to observe the dynamics of lifeLeica Room 15 042 Imaging CentreFast Label Free Live Cell Analysis with Digital Holographic MicroscopyLyncee Tech Microscopy room 117b Advanced Training CentreIntegrated 3D Imaging Workflows From Sample Prep to Stunning Results with the UltraMicroscope PlatformMiltenyi RTL Area B Advanced Training CentreAdvances in Automated imaging with Eclipse Ji and X Light V3Nikon FlexLab A Advanced Training CentreFrom Basics to brilliance Using the ONI Nanoimager with the Discovery Kit dSTORM in cells The ultimate kit to prepare your samples for super resolution with ease ONI Seminar room 125 Imaging CentreUnlock the Potential of Microscopy Images with AI Enhanced Analysis in Imaris 10 2Oxford Instruments Meeting room B28 Advanced Training CentreUltra thin Light Sheet Microscopy Providing Multi user Experience Combined with Automated Multi scale Imaging CapabilitiesPhaseView Microscopy room 116c Advanced Training CentrePerforming ISM FLIM with Luminosa s PDA 23 detection add onPicoQuant Lecture Hall 103 Imaging CentreAlignment Free Two Photon Microscopy with the Prelude SystemThorLabs Helix B Advanced Training CentreHolotomography the next imaging breakthrough is unlabeledTomocube Helix A Advanced Training CentreVisiTIRF Orbital 110 ISO RingTIRF illumination with new Ultra Flat Homogenizer Technology Visitron RTL Area A Advanced Training Centre Workshop 6 17 10 18 10 Download Workshop 6 abstracts Multicolor TIRF Imaging with Abbelight s SAFe SystemAbbelight Microscopy room 116b Advanced Training CentreAbberior STED MINFLUX Workshop Biological Imaging Across ScalesAbberior Session A Seminar room 114 Imaging CentreAbberior MINFLUX Workshop 3D and 2 colour MINFLUX nanoscopyAbberior Session B Seminar room 162 Imaging CentreAcquifer HIVE Efficient image data workflows Connecting acquisition with centralized storage and processingBruker Luxendo GmbH Seminar room 104 Imaging CentreUnlocking the Future of Imaging with ZEISS Lattice SIM 3Carl Zeiss Courtyard Room A Advanced Training CentreUltra Large Field of View Imaging Using Innovative Photonic Chip TechnologyChip Nanoimaging Microscopy room 512 ALMF Building 13 Multiplexed Confocal Imaging A High Throughput Approach to Deciphering Spatial OmicsCrest Optics Microscopy room 117a Advanced Training CentreMI SIM Advanced Mastering Intelligent Features for Super Resolution Live Cell ImagingCSR Biotech Microscopy room 116a Advanced Training CentreBest in class S N ratio and acquisition speed for LSM FV4000 with SiLVIR DetectorEvident Scientific FlexLab B Advanced Training CentreViventis Deep Open top multi sample dual view light sheet microscope for live imaging of large multicellular systemsLeica Courtyard Room B Advanced Training CentreFast Label Free Live Cell Analysis with Digital Holographic MicroscopyLyncee Tech Microscopy room 117b Advanced Training CentreIntegrated 3D Imaging Workflows From Sample Prep to Stunning Results with the UltraMicroscope PlatformMiltenyi RTL Area B Advanced Training CentreFrom samples to easy results with Artificial IntelligenceNikon FlexLab A Advanced Training CentreLipid Nanoparticles Harness the power of ONi super resolution expertise to characterise your LNP s with easeONI Seminar room 125 Imaging CentreWhen Seeing Fails and Objective Lens Truths Prevail Linking Microscope Quality Control Metrics to More Precise Biological ReadoutsOxford Instruments Meeting room B28 Advanced Training CentreUltra thin Light Sheet Microscopy Providing Multi user Experience Combined with Automated Multi scale Imaging CapabilitiesPhaseView Microscopy room 116c Advanced Training CentreMonitoring of dynamic processes An easy and reliable way to perform single molecule FRET and FCS measurementsPicoQuant Lecture Hall 103 Imaging CentreAlignment Free Two Photon Microscopy with the Prelude SystemThorLabs Helix B Advanced Training CentreHolotomography the next imaging breakthrough is unlabeledTomocube Helix A Advanced Training CentreSmart Imaging Feedback Microscopy with VisiView SoftwareVisitron RTL Area A Advanced Training Centre This page is kindly sponsored by Notice For the booking form and further questions please contact Erkin Ibragimov sponsorship coordinator with your request Exhibition ELMI 2025 will feature 45 exhibitors centrally located within the conference venue The exhibition will be accessible throughout the ELMI 2025 programme Visit exhibitors at ATC Foyer Level E2 ATC Reception Level A01 Helix A Join the exhibition and take advantage of this unique opportunity to network Download an exhibition hall plan Exhibitors Sponsorship Companies that have reserved exhibition stands and workshop rooms at ELMI2025 can further strengthen their presence by selecting additional opportunities to increase their visibility before and during the event Below is a table detailing all the currently available options Notice For the booking form and further questions please contact Erkin Ibragimov sponsorship coordinator with your request Media Partnership If you are interested in becoming a media partner of this event please visit our media partnerships webpage Media partners ChemBioChem a Wiley journal Development The Company of Biologists journal EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Methods in Microscopy de Gruyter open access journal Microcscopy and Analysis a Wiley journal Open Biology a Royal Society journal Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions Please note workshops will not be livestreamed available on demand On site Academia 650On site PhD Student 500On site Industry 650On site Journal Editors 300Virtual Academia 250Virtual PhD Student 175Virtual Industry 250 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Aline Schnieder for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 2 May 2025 in some cases at special rates Please email the hotel directly quoting the booking code ELM25 01 to confirm the exact price of the room Hotel AnlageHilton HeidelbergHotel MonptiHotel Bayrischer Hof Hotel Holl nder Hof Premier Inn Heidelberg City ZentrumB B HotelHotel ibis HeidelbergStaycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreHotel Vier Jahreszeiten Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 You can find the conference shuttle timetable here View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page Football match Academy vs Industry All registered participants are invited to the traditional football match Academy vs Industry sponsored by EVIDENT The football match is taking place on Tuesday 3 June 16 00 17 00 at Sportanlage Boxberg Turnerbund Rohrbach Boxberg Boxbergring 51 69126 Heidelberg A bus shuttle will take players and spectators to the venue Participation will be possible upon registration As there is only capacity for 16 players on each team places will be given out on a first come first served basis If you would like to play please contact Team AcademyTeam IndustryDr Peter O Toole Director of the Bioscience Technology Facility Head of Imaging and CytometryBioscience Technology FacilityUniversity of Yorkpot1 york ac ukAndrea RackowRegional Marketing ManagerEVIDENT Europe GmbHandrea rackow evidentscientific com If you would like to join as spectator and cheer for your team please contact Aline Schnieder for a spot on the shuttle bus All support is welcome Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Elisa D’Este, Ulrike Engel, Elisa May, Rainer Pepperkok, Stefan Terjung, Timo Job Kristian Zimmermann

2 June - 6 June 2025

Interdisciplinary challenges in the physics of complexity and life 2025 (IntCha25)

Description OverviewSpeakersProgrammePractical information Overview Conference overview This conference aims at connecting young researchers from diverse backgrounds at the interface between the physics of complex systems and biology to build networks and new collaborations both across fields and between theoreticians and experimentalists The talks will span a variety of topics from soft matter to biology and statistical physics As the conference is aimed at early career researchers we strongly support applications from PhD students postdocs and early career permanent researchers Since we are aware of the financial difficulties faced by young researchers participants that are accepted for poster presentations will have the opportunity to apply to a travel grant We will notably support environmentally friendly travelling options within our financial capabilities Keynote Speakers Kate Jensen Williams University USA Stefania Melillo Institute for Complex Systems Consiglio Nazionale delle Ricerche CNR Italy Pierre Ronceray Turing Centre for Living Systems CENTURI and Centre Interdisciplinaire de Nanosciences de Marseille CINAM France Session topics Biopolymers Simon Grosse Holz Maxime Vassaux Stefanie Heyden Mobility and transport Maria Tatulea Codrean Patrick Li Helena Massana Cid Irreversible processes Marco Baldovin Salambo Dago Sarah Loos Cell biophysics Achille Joliot Maitane Mu oz Basagoiti Nicolas Romeo Active matter Ivan Palaia Kristian Thijssen Olga Bantysh Decision making Laura Capolupo Nicola Rigolli Henry Mattingly Active solids and tissue biophysics Irene Nagle Amelie Chardac Carolina Trenado Yuste Learning and networks Menachem Stern Antonio Costa Akhilesh Nandan Ecology and evolution Oliver J Meacock Nora Martin Alberto Dinelli Oral presentations are invitation only Applicants are encouraged to submit an abstract for a poster presentation Image credits From left to right Image courtesy of Simon Grosse Holz Figure from Mary G Mazuel F Nier V Fage F Nagle I Devaud L Reffay M 2022 All in one rheometry and nonlinearrheology of multicellular aggregates Physical Review E 105 5 054407 Image courtesy of Jonathan Jackson and Nicolas Romeo Figure from Capolupo L Khven I Lederer A R Mazzeo L Glousker G Ho S D Angelo G 2022 Sphingolipids controldermal fibroblast heterogeneity Science 376 6590 eabh1623 Figure from Stern Menachem et al Supervised learning in physicalnetworks From machine learning to learning machines Physical Review X11 2 2021 021045 Speakers Keynote speakers Kate Jensen Williams University USA Stefania Melillo CNR Rome Italy Pierre Ronceray Turing Centre for Living Systems Marseille France Speakers Marco Baldovin CNR Rome Italy Olga Bantysh University of Barcelona Spain Laura Capolupo FMI Basel Switzerland Amelie Chardac Brandeis University USA Antonio Costa Paris Brain Institute Sorbonne University France Salambo Dago University of Vienna Austria Alberto Dinelli University of Geneva Switzerland Simon Grosse Holz MPI PKS and MPI CBG Dresden Germany Stefanie Heyden ETH Z rich Switzerland Achille Joliot AMOLF Netherlands Patrick Li IST Austria Sarah Loos Cambridge University United Kingdom Nora Martin Barcelona Collaboratorium Spain Helena Massana Cid Sapienza University of Rome Italy Henry Mattingly Flatiron Institute NYC USA Oliver J Meacock University of Sheffield United Kingdom Maitane Mu oz Basagoiti IST Austria Irene Nagle TU Delft Netherlands Akhilesh Nandan EMBL Barcelona Spain Ivan Palaia IST Austria Nicola Rigolli ENS Paris France Nicolas Romeo University of Chicago USA Menachem Stern AMOLF Netherlands Maria Tatulea Codrean University of Cambridge United Kingdom Kristian Thijssen Niels Bohr Institute Copenhagen Denmark Carolina Trenado Yuste Princeton University USA Maxime Vassaux CNRS Universit de Rennes France Scientific organisers Aleksandra Ardaseva Niels Bohr Institute Copenhagen Denmark Nicolas Bain Institut Lumi re Mati re Lyon France Federica Ferretti NITMB Chicago USA Isabella Graf EMBL Heidelberg Germany Lara Koehler MPI PKS Germany Dario Lucente University of Campania Italy Giuseppe Negro University of Edinburgh United Kingdom Paul Robin IST Austria Gianmarco Spera University of Oxford United Kingdom Programme Please note that the programme is subject to change Day 1 Monday 2 June 2025 Time Europe Berlin Session12 00 14 00Registration14 00 14 30Introductory remarks14 30 15 00Bridging the gap between bulk rheology and local cell matrix interaction via rheoconfocal microscopyIrene Nagle TU Delft Netherlands15 00 15 303D pattern formation of a protein membrane suspensionAmelie Chardac Brandeis University USA15 30 16 00TBCCarolina Trenado Yuste Princeton University USA16 00 16 30Coffee Break16 30 18 30Poster Session 118 30 23 00Dinner at EMBL Day 2 Tuesday 3 June 2025 Time Europe Berlin Session08 30 09 00Coffee09 00 09 45TBCKate Jensen Williams University USA09 45 10 30Coffee Break10 30 11 00Three sides of the same coin Unifying context dependencies of ecological interactionsOliver J Meacock University of Sheffield UK11 00 11 30How can we model variation through random mutations in evolutionary processes Nora Martin Barcelona Collaboratorium Spain11 30 12 00Motility induced self organization of microbial ecosystems from non reciprocity to weak random interactionsAlberto Dinelli University of Geneva Switzerland12 00 14 00Lunch14 00 14 30Electrical control of the transduction channels mechanosensitivity in sensory hair cellsAchille Joliot AMOLF Netherlands14 30 15 00Shape through gradients Deformations of chemically active membranesMaitane Mu oz Basagoiti IST Austria15 00 15 30Scaling behavior of nuclear wrinklingNicolas Romeo University of Chicago USA15 30 16 15Coffee Break16 15 17 15Editor presentation17 15 17 45Discussions17 45 19 15Drinks Day 3 Wednesday 4 June 2025 Time Europe Berlin Session08 30 09 00Coffee09 00 09 45Characterization of lab adapted swarms of Anopheles gambiae mosquitoesStefania Melillo CNR Rome Italy09 45 10 30Coffee Break10 30 11 00Dividing cells how actin constricts the membraneIvan Palaia IST Austria11 00 11 30Active particles knead three dimensional gels into open crumbsKristian Thijssen Niels Bohr Institute Copenhagen Denmark11 30 12 00Reorganizing active nematics flows with thermotropic liquid crystalsOlga Bantysh University of Barcelona Spain12 00 13 30Lunch13 30 14 00Learning without neurons in physical systemsMenachem Stern AMOLF Netherlands14 00 14 30Multiscale modelling for unravelling plasticity and variability in animal behavior Antonio Costa Paris Brain Institute Sorbonne University France14 30 15 00Ghost states guiding transients away from fixed pointsAkhilesh Nandan EMBL Barcelona Spain15 00 15 30Coffee Break15 30 17 00Q A session17 00 19 00Poster Session 2 Day 4 Thursday 5 June 2025 Time Europe Berlin Session08 30 09 00Coffee09 00 09 45Learning the out of equilibrium dynamics of biological matterPierre Ronceray Turing Centre for Living Systems Marseille France09 45 10 30Coffee Break10 30 11 00Mechanochemical coupling during intestinal crypt morphogenesisLaura Capolupo FMI Basel Switzerland11 00 11 30Trail following and open air navigation how mice make decisions with sparse olfactory signalsNicola Rigolli ENS Paris France11 30 12 00Ultrasensitivity without conformational spread a mechanical origin for non equilibrium cooperativity in the bacterial flagellar motorHenry Mattingly Flatiron Institute NYC USA12 00 13 30Lunch13 30 14 00Optimal control of levitated nanoparticles through finite stiffness confinementMarco Baldovin CNR Rome Italy14 00 14 30Thermodynamic of information probing the cost of an irreversible information processing using an underdamped memorySalambo Dago University of Vienna Austria14 30 15 00TBCSarah Loos Cambridge University UK15 00 15 30Announcements15 30 18 00Excursion Heidelberg Day 5 Friday 6 June 2025 Time Europe Berlin Session08 30 09 00Coffee09 00 09 30Bayesian parameter inference for particle trackingSimon Grosse Holz MPI PKS and MPI CBG Dresden Germany09 30 10 00Heterogeneous structure dynamics and mechanics in a hydrated collagen microfibrilMaxime Vassaux CNRS Universit de Rennes France10 00 10 30How diversity matters in flexible networksStefanie Heyden ETH Z rich Switzerland10 30 11 00Coffee Break11 00 11 30Memory effects in bacterial flagellar dynamicsMaria Tatulea Codrean Cambridge UK11 30 12 00Channeling cells in plantsPatrick Li IST Austria12 00 12 30Out of equilibrium dynamics of magnetic colloidal crystals activated by light driven bacteriaHelena Massana Cid Sapienza University of Rome Italy12 30 13 00Concluding remarks Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses On site Academia 375On site PhD Student 375On site Industry 500 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact intCha for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract for poster presentation After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for a poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided in the form of travel grants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities For further information about financial assistance please refer to the FAQ page Travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs...

1 June - 6 June 2025

Whole transcriptome data analysis

Description OverviewSpeakers trainers and staffProgrammePractical informationSponsorsMedia kit Overview Course overview This course will teach biological researchers how to analyse biological data sets using open source software Most of the analysis will be performed with docker4seq and rCASC packages which were developed to facilitate the use of computing demanding applications in the field of NGS data analysis Docker4seq and rCASC packages use docker containers that embed demanding computing tasks e g short reads mapping into isolated containers This approach provides multiple advantages the user does not need to install all the software on its local server the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used for the analysis Computers for hands on exercises will be provided along with demo data sets Audience This course was developed for biological researchers as the intended audience Basic knowledge of massively parallel sequencing MPS is desirable however R coding skills and deep knowledge of statistics are not necessary What past participants say about the course This course has been an incredibly enriching and valuable experience for me providing comprehensive knowledge practical methodologies and invaluable networking opportunities The instructors expertise and the hands on approach made the learning process engaging and enjoyable The interactive sessions allowed us to apply what we learned to real world scenarios Also meeting fellow participants from diverse backgrounds and sharing ideas was inspiring The networking opportunity created a collaborative and supportive environment fostering future collaborations I am grateful to the EMBL team for organizing this exceptional course The high quality organization knowledgeable instructors and dedicated staff made it an outstanding learning environment Thank you for providing this excellent learning opportunity Oana Baldasici The Oncology Institute Prof Dr Ion Chiricuta Cluj Napoca Romania This course has orientated me in the world of bioinformatics and has given me the tools to find a path through my data analysis It has also given me a group of friends to call when I have problems along the way I wish I could do it again Alysha Burrows Manchester Metropolitan University UK Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course Speakers trainers and staff Luca Alessandri University of Turin Italy Marco Beccuti University of Turin Italy Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Maria Luisa Ratto University of Turin Italy Scientific organisers Marco Beccuti University of Turin Italy Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Course Organiser Inna B sselmann EMBL Heidelberg Germany Programme Day 1 Sunday 1 June 2025 Time Berlin Europe SpeakerLocation14 00 14 30Welcome and course overviewVladimir Benes EMBL Heidelberg GermanyCourtyard A B room14 30 15 00Participants flash talksCourtyard A B room15 00 16 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard A B room16 00 16 30Coffee breakCourtyard A B room16 30 18 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard A B room18 00 19 30Pizza dinner in the rooftop loungeRooftop lounge19 30Bus to ISG HotelATC Entrance Day 2 Monday 2 June 2025 Time Berlin Europe SpeakerLocation08 40 09 00Bus from ISG to EMBLISG Hotel entrance09 00 10 00Docker container and reproducibilityMarco Beccuti University of Turin ItalyComputer Training Lab10 00 10 30Coffee breakATC Foyer10 30 11 00Experimental design bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab11 00 12 00QC bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Counting reads bulk RNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab14 30 15 00Coffee breakATC Foyer15 00 17 30Counting reads miRNARaffaele Calogero University of Turin ItalyComputer Training Lab17 30 18 30Social programme Facility tour18 30 19 30DinnerEMBL Canteen19 30Bus to ISG HotelATC Entrance Day 3 Tuesday 3 June 2025 Time Berlin Europe SpeakerLocation08 40 09 00Bus from ISG to EMBLISG Hotel entrance09 00 10 30PCA a linear dimensionality reduction methodRaffaele Calogero University of Turin ItalyComputer Training Lab10 30 11 00Coffee breakATC Foyer11 00 12 30Differential expression analysis for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 14 30Differential expression analysis for multiple groups ANOVA likeRaffaele Calogero University of TurinComputer Training Lab14 30 16 00Visualising differentially expressed data Heat maps Raffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab16 00 16 30Coffee breakATC Foyer16 30 18 00Mining differential expression results for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab18 00 19 00DinnerEMBL Canteen19 00Bus to ISG HotelATC Entrance Day 4 Wednesday 4 June 2025 Time Berlin Europe SpeakerLocation08 40 09 00Bus from ISG to EMBLISG Hotel entrance09 00 11 00Individual exercises on bulk RNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab11 00 11 30Coffee breakATC Foyer11 30 12 30Individual exercises on bulk RNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab12 30 13 30Lunch and group photoEMBL Canteen13 30 14 30QC single cells RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab14 30 16 00Non linear dimensionalityreduction for single cell RNAseqRaffaele Calogero University of TurinComputer Training Lab16 00 16 30Coffee breakATC Foyer16 30 18 00Sub population discovery insingle cell RNAseq clusteringRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab18 00 18 30Social dinner downtownBus to ISG from EMBL ATC 20 minutes at ISG hotel to drop things ATC Entrance18 30 19 00Bus from ISG to Neckarm nzplatzISG Hotel19 00Downtown dinner Day 5 Thursday 5 June 2025 Time Berlin Europe SpeakerLocation08 40 09 00Bus from ISG to EMBLISG Hotel entrance09 00 10 00Annotating cell types aftersub population discoveryRaffaele Calogero University of Turin ItalyComputer Training Lab10 00 11 00ExercisesComputer Training Lab11 00 11 30Coffee breakATC Foyer11 30 12 30scRNA data integrationRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Individual exercises on bulk RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab16 00 16 30Coffee breakATC Foyer16 30 18 30Individual exercises on single cell RNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab18 45Bus to ISG HotelATC Entrance19 30Dinner at ISG HotelISG Hotel Day 6 Friday 6 June 2025 Time Berlin Europe SpeakerLocation08 40 09 00Bus from ISG to EMBLISG Hotel entrance09 00 11 00Individual exercises on bulk single cellRNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab11 00 11 30Coffee breakATC Foyer11 30 12 30Individual exercises on bulk single cellRNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Individual exercises on bulk single cellRNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab16 00 16 20Final remarksVladimir Benes Raffaele Calogero Marco BeccutiComputer Training Lab16 30Bus to Heidelberg train stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 28 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 750PhD Student 750Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights from Saturday 31 May Friday 6 June at the ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course e g DAT25 01 by the deadline of Wednesday 30 April 2025 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Marco Beccuti, Vladimir Benes, Raffaele Calogero, Francesca Cordero

28 May 2025

Towards open and standardised imaging data: an introduction to Bio-Formats, OME-TIFF, and OME-Zarr

Description Microscopy and bioimaging technologies are fundamental tools for exploring biological systems generating large multidimensional datasets rich in experimental detail However the bioimaging community has historically faced major challenges around data handling vendor specific proprietary formats fragmented metadata storage and increasingly large dataset sizes that outstrip traditional storage and computing solutions In this webinar we will present key open technologies developed by the Open Microscopy Environment OME to address these challenges Specifically we will introduce the Bio Formats library for accessing diverse proprietary file formats the OME TIFF standard for archival data storage and the OME Zarr format for cloud native scalable bioimaging workflows We will show how these technologies can be used to Read and standardise imaging datasets from hundreds of proprietary file formatsStore data and metadata together in accessible interoperable formatsEnable scalable storage and analysis of large multidimensional imaging datasets using modern cloud and cluster environmentsImprove data sharing and reproducibility in line with FAIR Findable Accessible Interoperable Reusable principles...

26 May - 28 May 2025

Infection: pathogens, hosts, and microbiomes

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Infectious diseases are among the most prevalent causes of human illness and death in the world Epidemics pandemics have shaped human evolution and history and although for a while they were considered a solved problem for the developed world the recent past has showed us all why this is not the case Antimicrobial resistance global warming human population size increase modern lifestyles urbanization traveling decrease of wild life habitats for pathogen reservoirs all contribute to creating an ideal setting for infectious diseases becoming an even greater challenge in the future This symposium will bring together experts working on different pathogens viruses bacteria fungi and parasites who rarely meet It will cover a broad range of topics on the host pathogen interface highlighting the diversity in mechanisms and the convergence of strategies pathogens use to invade hijack host machineries proliferate within the host cause disease and spread to other hosts Infection biologists using systems biology population genomics genetics cell and tissue biology biochemistry and structural biology will meet to present the state of the art of different fields The emerging realisation that infections are often polymicrobial pathogens can be opportunistic and already reside for years as benign in our body and that the microbiome can greatly impact infection onset and progress will provide a common thread of discussion across fields of different pathogenic agents Discussions will fertilise transfer of technologies and know how across fields and set the ground for developing new strategies to tackle current bottlenecks in our ability to treat infections Session topics Structural aspects of infection Global analysis of pathogens Pathogen cell dialogues Pathogen tissue interactions Microbiome evolution and beyond Speakers Maria Bernabeu EMBL Barcelona Spain Melanie Blokesch EPFL Switzerland Rachel Edgar Imperial College London UK Luisa Figueiredo Instituto de Medicina Molecular Jo o Lobo Antunes Portugal Freddy Frischknecht Heidelberg University Hospital Germany Andrew Gewirtz Georgia State University USA Melanie Hamon Institut Pasteur France Jan Kosinski EMBL Hamburg CSSB Centre for Structural Systems Biology Germany Maryse Lebrun Universit de Montpellier France Hiten Madhani University of California San Francisco USA Julia Mahamid EMBL Heidelberg Germany Kim Orth University of Texas Southwestern Medical Center USA B rbel Stecher Technical University of Munich TUM Germany Nick Talbot The Sainsbury Laboratory UK Jan Willem Veening University of Lausanne Switzerland Michael Way The Francis Crick Institute UK Scientific organisers Maria Bernabeu EMBL Barcelona Spain Pascale Cossart Institut Pasteur France Hiten Madhani University of California San Francisco USA Kim Orth University of Texas Southwestern Medical Center USA Michael Way The Francis Crick Institute UK Conference organiser Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EESInfection and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 1 Monday 26 May 2025 Time Europe Berlin Session11 30 13 00Registration and light refreshments13 00 13 15Opening remarks13 15 13 55Keynote lecture Illuminating infection by in cell structural biologyJulia Mahamid EMBL Heidelberg Germany13 55 16 40Session 1 Structural aspects of infectionChair Pascale Cossart Institut Pasteur France13 55 14 20Ultrastructural imaging of poxvirus exit from infected cellsMichael Way The Francis Crick Institute United Kingdom14 20 14 35Segmented filamentous bacteria undergo a structural transition at their adhesive tip during unicellular to filament developmentAna Raquel Cruz Institut Necker Enfants Malades FranceNot available on demand14 35 14 50Structural basis of Fusobacterium nucleatum adhesin Fap2 interaction with receptors on cancer and immune cellsDaniel Roderer Leibniz Forschungsinstitut f r Molekulare Pharmakologie FMP Germany14 50 15 20Coffee break and meet the speakers15 20 15 45Decoding the mechanisms of rhoptry secretion in apicomplexan parasitesMaryse Lebrun Universit de Montpellier FranceNot available on demand15 45 16 00Broadly inhibitory antibodies against severe malaria associated PfEMP1Sai Sundar Rajan Raghavan Scripps Research USA16 00 16 15Biochemical insights into CadC A metal responsive regulator of virulence in Listeria monocytogenesDiana Meireles Instituto de Investiga o e Inova o em Sa de I3S Portugal16 15 16 40Exploring bacterial immunity of the human pathogen Vibrio choleraeMelanie Blokesch EPFL SwitzerlandNot available on demand virtual speaker 16 40 17 15Flash talk session 117 15 18 45Poster Session 1 odd numbers 18 45 20 15Dinner in EMBL Canteen20 15 21 45Science Trivia Night in Canteen and drinks Day 2 Tuesday 27 May 2025 Time Europe Berlin Session09 00 11 45Session 2 Global analysis of pathogensChair Kim Orth University of Texas Southwestern Medical Center USA09 00 09 25Insights into the pneumococcal life style by multiomics profiling and dual CRISPRi seqJan Willem Veening University of Lausanne Switzerland09 25 09 40A scalable gut epithelial organoid model reveals the genome wide colonization landscape of a human restricted pathogenMaria Letizia Di Martino Uppsala University SwedenNot available on demand09 40 09 55A viral phosphorylation strategy that broadly disarms host defensesKarin Mitosch EMBL Heidelberg Germany09 55 10 20In cell structural biology of influenza A virus infectionJan Kosinski EMBL Hamburg CSSB Centre for Structural Systems Biology Germany10 20 10 50Coffee break and meet the speakers10 50 11 05Unraveling Burkholderia cenocepacia s adaptability virulence and interbacterial competitionEva Mortier Ghent University Belgium11 05 11 20The ER protein translocation channel subunit Sbh1 controls virulence of Cryptococcus neoformans CANCELLED Karin R misch Saarland University Germany11 20 11 45EMBO Young Investigator LectureNatural killer cell memory to Streptococcus pneumoniae infectionMelanie Hamon Institut Pasteur France11 45 13 15Lunch12 30 13 15ERC information session13 15 16 20Session 3 Pathogen cell dialoguesChair Michael Way The Francis Crick Institute United Kingdom13 15 13 40Vibrio parahaemolyticus invasion proliferation escapeKim Orth University of Texas Southwestern Medical Center USA13 40 13 55Antibodies induce selective autophagy of viruses and bacteriaTyler Rhinesmith Medical Research Council United Kingdom13 55 14 10Learning new infectivity tricks from old endogenous retrovirusesMaya Voichek Institute of Molecular Biotechnology IMBA Austria14 10 14 35The regulation of infection associated morphogenesis by the blast fungus Magnaporthe oryzaeNick Talbot The Sainsbury Laboratory United Kingdom14 35 15 05Coffee break and meet the speakers15 05 15 20Introducing cell organization and disturbance mapping using image activated cell profiling CODIAC Melanie Krause EMBL Heidelberg Germany15 20 15 45Molecular mechanisms of host homeostasis cellular communication immunity and infectionRachel Edgar Imperial College London United Kingdom15 45 16 20Flash talk session 216 20 17 50Poster Session 2 even numbers 17 50 19 20Dinner in EMBL Canteen19 20 22 20After dinner drinks and Party with DJ Rotard Day 3 Wednesday 28 May 2025 Time Europe Berlin Session09 00 12 00Session 4 Pathogen tissue interactionsChair Hiten Madhani University of California San Francisco USA09 00 09 25Breaking barriers a 3D blood brain barrier model for cerebral malaria researchMaria Bernabeu EMBL Barcelona Spain09 25 09 40Exploration of the in vivo genome wide fitness of Streptococcus pneumoniae during pneumococcal meningitis by CRISPRi seqKin Ki Jim University of Lausanne Switzerland09 40 09 55A stem cell driven culture model of the human stomach for studying the immunological properties of secreted mucusFrancesco Boccellato University of Oxford United Kingdom09 55 10 20Malaria research from fundamental science to new interventionsFreddy Frischknecht Heidelberg University Hospital Germany10 20 10 50Coffee break and meet the speakers10 50 11 05Host pathogen interaction boosts pathogenicity in periodontitisOlena Moshynets Institute of Molecular Biology and Genetics of NAS of Ukraine Ukraine11 05 11 204D in vivo dynamics of phagocytosis by epithelial tissuesEsteban Hoijman IBMB CSIC SpainNot available on demand11 20 11 35An immunocompetent human iPSC derived multicellular Alveolus on Chip reveals early pathological events of M tuberculosis infectionChak Hon Luk The Francis Crick Institute United Kingdom11 35 12 00Host fat under attack during a Trypanosome infectionLuisa Figueiredo Instituto de Medicina Molecular Jo o Lobo Antunes PortugalNot available on demand12 00 13 30Lunch and meet the editors13 30 16 15Session 5 Microbiome evolution and beyondChair Maria Bernabeu EMBL Barcelona Spain13 30 13 55Gut microbiota alveolar macrophages and respiratory viral infection severityAndrew Gewirtz Georgia State University USA13 55 14 10Dysbalance of the murine lung microbiome induced by Aspergillus fumigatus infectionLiubov Nikitashina Institute for Natural Product Research and Infection Biology Hans Kn ll Institute Leibniz HKI Germany14 10 14 25C type lectin receptor sequencing is a novel platform to study glycan mediated immune selection of bacterial species at host barrier sitesJasper Mol Amsterdam UMC The Netherlands14 25 14 55Coffee break and meet the speakers14 55 15 10Translation control by altered start codon usage as a means of modulating the general stress response and virulence in Listeria monocytogenesJialun Wu University of Galway Ireland15 10 15 35Ecological and evolutionary mechanisms underly intestinal colonization resistanceB rbel Stecher Technical University of Munich TUM GermanyNot available on demand15 35 16 15Keynote lecture Phenotypic landscape of an invasive fungal pathogen reveals its unique biologyHiten Madhani University of California San Francisco USA16 15 16 30Closing remarks and poster prize announcements16 30Shuttle bus from EMBL ATC to Frankfurt airport Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 650On site PhD Student 550On site Industry 850On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Catherine Casas Saavedra for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 24 April 2025 in some cases at special rates Please email the hotel directly quoting the booking code EES25 04 to confirm the exact price of the room Hotel AnlageISG Hotel Premier Inn Heidelberg City ZentrumHilton HeidelbergMeininger HeidelbergThe Heidelberg Exzellenz Hotel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Media partners ChemBioChem a Wiley journal International Union of Biochemistry and Molecular Biology Journal of Molecular Biology an Elsevier journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal The EMBO Journal an EMBO Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

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BioMalPar XXI: biology and pathology of the malaria parasite

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Malaria remains a significant global public health challenge with increasing drug resistance COVID interruptions to interventions and rising malaria deaths confounding our efforts against this persistent disease BioMalPar reaffirms our commitment to understanding the Plasmodium parasite and its interactions with hosts and vectors Despite the challenges there are promising developments new drug combinations are showing efficacy and we now have two approved vaccines that offer hope for the future Meeting for the 21st time BioMalPar 2025 focusses on strengthening our global research community by fostering new partnerships and collaborations We acknowledge that defeating malaria requires a united effort across continents and disciplines and we reflect this with our diverse line up of speakers The upcoming conference provides an invaluable platform for scientists worldwide to convene share critical insights and explore cutting edge technologies Together we can drive forward the innovations and strategies needed to reduce the terrible toll malaria takes Join us in this crucial endeavour to understand the biology of the malaria parasite and to advance global health Topics Epidemiology the epidemiology of malaria in endemic countries Vaccines and immunity how vaccines can alter this landscape Vector and transmission what role transmission through the mosquito vector plays Molecular and cellular biology the molecular and cellular biology of the parasite Drug targets and resistance and how we can use these findings to find new drug targets and combat resistance Speakers Keynote Speakers Abdoulaye Djimde Bamako University Mali Sarah Reece University of Edinburgh UK Speakers Amy Bei Yale Institute for Global Health USA Pierre Buffet Institut Pasteur France Ellen Bushell Umea University Sweden Yi Wei Chang University of Pennsylvania USA Laurent Dembele Malaria Research and Training Center Africa Simon Draper Oxford University UK Saman Habib CDRI Lucknow India Azza Idris Ragon Institute USA Maryse Lebrun University of Montepelier France Maria Mota Gulbenkian Institute for Molecular Medicine Portugal Kevin Tetteh FIND Switzerland Till Voss Swiss Tropical and Public Health Institute Switzerland Scientific Organisers Yaw Aniweh University of Ghana Ghana Lilian Mancio Silva Institut Pasteur France Wiebke Nahrendorf University of Edinburgh UK Stuart Ralph University of Melbourne Australia Conference Organiser Chris Stocks Course and Conference Team Lead EMBL Heidelberg Germany Programme Are you on social media Post using EMBLMalaria and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here Day 1 Tuesday 20 May 2025 Time Europe Berlin Speaker11 30 13 00 Registration and light refreshments13 00 13 15Opening remarks by Scientific organisers13 15 14 15Plasmodium genomics for malaria elimination in sub saharan AfricaAbdoulaye Djimde Bamako University Mali14 15 17 00Session 1 epidemiologyChair Stuart Ralph University of Melbourne AustraliaCo chair Ashley Vaughan Seattle Children s Research Institute USA14 15 14 45Leveraging potent monoclonal antibodies to guide the design of next generation malaria vaccines Azza Idris Ragon Institute USA14 45 15 00The origin and evolution of Plasmodium falciparumMartha Kivecu University of Edinburgh UK15 00 15 15High altitude malaria transmission evidence of Plasmodium vivax persistence and local spread in EthiopiaGustavo da Silva University of Notre Dame USA15 15 15 45Coffee Break15 45 16 15Traversing the valley of death successfully translating research into diagnostics Kevin Tetteh FIND Switzerland16 15 16 30Decoding the functional and evolutionary impact of sickle associated loci in the Plasmodium falciparum genomeAnnie Forster University of Oxford UK16 30 16 45Plasmodium falciparum establishes chronic infections through high var gene expression switching rateMathieu Quenu University of Montpellier France16 45 17 15Flash talk session 1 35 Laura Akkerman 43 Jordan Barrett 45 Ezra Bekkering 55 Claudia Camarero Hoyos 69 Jerzy Dziekan 87 Jessica Home 103 Duangkamon Loesbanluechai 115 Petter Michaela 17 15 17 30DiscussionFuture of PlasmoDB David Roos University of Pennsylvania USA17 30 18 45Poster Session 1 odd numbers 18 45 20 15Dinner in canteen20 15 20 45Lifetime achievement award20 45 22 00After dinner drinks Day 2 Wednesday 21 May 2025 Time Europe Berlin Speaker09 00 12 00 Session 2 Vaccines and immunityChair Wiebke Nahrendorf University of Edinburgh UKCo chair Steven Kho Menzies School of Health Research Australia09 00 09 30Plasmodium liver stage silently making a bangMaria Mota Gulbenkian Institute for Molecular Medicine Portugal09 30 09 45The contribution of leukocytes to cerebral malaria vascular pathogenesis in a 3D blood brain barrier modelAlina Batzilla EMBL Barcelona Spain09 45 10 00Using Plasmodium knowlesi and bar seq to unravel the effect of PvDBP polymorphisms in parasite fitness and antibody susceptibilityKonstantinos Kousis London School of Hygiene Tropical Medicine UK10 00 10 30Coffee Break10 30 11 00How the spleen senses retains and processes erythrocytes insights into the pathogenesis and control of malaria Pierre Buffet Institut Pasteur France11 00 11 15A systems level dissection of the host response to Plasmodium falciparum during asymptomatic infection and malaria in the same individualFlorian Bach Stanford University USA11 15 11 45Advances in vaccines for blood stage malariaSimon Draper University of Oxford UK11 45 12 00Targets of circumsporozoite protein based malaria vaccines what we missed in 1987 and what is missing nowFranklin Nuokpem University of Ghana Ghana Virtual talk 12 00 13 30Meet the speakers and Lunch12 15 13 15Women in Malaria peer to peer lunchtime workshopSarah Reece University of Edinburgh UKElena Gomez Institute of Parasitology Biomedicine Spain limited spaces onsite only 13 30 17 00Session 3 Vectors and transmissionChair Liliana Mancio Institut Pasteur FranceCo chair Matthijs Jore Radboud University Medical Center The Netherlands13 30 14 30Keynote lectureIt s about time Daily rhythms in malaria infectionsmatter for parasite survival and transmission Sarah Reece University of Edinburgh UK14 30 14 45Mapping Plasmodium falciparum transitions and interactions in the anopheles female at the single cell resolutionLisa Verzier Harvard University USA14 45 15 00Defining transcriptional signatures of Plasmodium falciparum hematopoietic infection at the single cell levelBarbara Stokes University of Glasgow UKNot available on demand15 00 15 30Coffee Break15 30 16 00How efforts in studying singular var gene choice led to the identification of a new factor essential for Plasmodium falciparum replicationTill Voss Swiss Tropical and Public Health Institute University of Basel Switzerland16 00 16 15N6 methyladenosine primes the malaria parasite transcriptome for transmissionSelina Mussgnug Institut Pasteur France16 15 16 30Multistage requirement of the microtubule binding protein DCX during mosquito gut colonization by Plasmodium falciparumEmma Ganga University of Geneva Switzerland16 30 17 05Flash talk session 2 38 Eduardo Alves dos Santos 40 Kodzo Atchou 46 Sandra Bennink 54 Filipa C Neves 68 Krishanpal Karmodiya 70 Rebecca Edgar 80 Amke Hackmann 90 Long Huynh 96 Ashton Kelly 98 Steven Kho 102 Henrico Langeveld 108 Andrew McCluskey 110 Sherihan Musa 124 Barbara Diaz Terenti 130 Madhavi Shukla17 05 18 30Poster Session 2 even numbers 18 30 20 00Conference dinner in EMBL Canteen20 00 23 00Party with live band Athi Rocks Day 3 Thursday 22 May 2025 Time Europe Berlin Speaker09 00 13 30Session 4 Molecular and cellular biologyChair Catherine Merrick University of Cambridge UKCo chair Julie Verhoef University of Cambridge UK09 00 09 30Identification of novel Plasmodium virulence factors and their role in malaria infection and diseaseEllen Bushell Umea University Sweden09 30 09 45Sequential resource sharing speeds up Plasmodium falciparum proliferationPatrick Binder German Cancer Research Centre Germany09 45 10 00Locked out and left behind a study of organellar inheritance in PlasmodiumSophie Collier The University of Melbourne Australia10 00 10 30Coffee Break10 30 11 00Studying the apicomplexan rhoptry secretion system by cryo electron tomographyYi Wei Chang University of Pennsylvania USA11 00 11 15Striated fiber assemblins underpin the fidelity of asexual replication in Plasmodium falciparumIIzat Ali Harvard Medical School USA11 15 11 45Decoding the molecular mechanisms of rhoptry secretion in Toxoplasma gondiiMaryse Lebrun University of Montpellier FranceNot available on demand11 45 12 00Redefining var gene expression dynamics a single cell perspective on immune evasion in Plasmodium falciparumFrancesca Florini Weill Cornell Medicine USA12 00 13 30Meet the speakers and Lunch12 00 13 30 Lunch time workshop PlasmoDB VEuPathDB workshopDavid Roos University of Pennsylvania USA13 30 16 15Session 5 Drug targets and resistanceChair Stuart Ralph University of Melbourne AustraliaCo chair Jerzy Dziekan Walter and Eliza Hall Institute of Medical Research Australia13 30 14 00Nucleases for Plasmodium falciparum organelle genome maintenance and role of an LCR in DNA substrate repertoire expansionSaman Habib CSIR Central Drug Research Institute India14 00 14 15Impact of COVID 19 pandemic in parasite populations from the Western Brazilian AmazonRoberto Moraes Barros UNIFESP Brazil14 15 14 30Quinoxaline based anti schistosomal compounds have potent anti plasmodial activityMukul Rawat University of Dundee UK14 30 15 00Coffee break15 00 15 30Using real world parasites biology to guide translational malaria drug discovery programsLaurent Dembele Malaria Research and Training Center Mali15 30 15 45Deconvolution of the on target activity of plasmepsin V peptidomimetics in Plasmodium falciparum parasitesMadeline G Dans Walter and Eliza Hall Institute of Medical Research Australia15 45 16 00Targeting Plasmodium myosins to fight malariaJulien Robert Paganin Institut Curie France16 00 16 30Genetic and genomic approaches to inform malariavaccinology lessons from the fieldAmy Bei Yale School of Public Health USA16 30 16 45Closing remarks and poster prize announcements Practical Information Choosing onsite vs virtual participation You can choose to attend the conference either onsite in Heidelberg or virtually If you hope to present your research you need to decide which mode suits you best before the abstract submission deadline considering the below If you plan to attend the conference onsite you can register and apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline Please note that once you have registered for onsite attendance and submitted an abstract for an oral presentation you will still have the opportunity to present a poster onsite even if not selected for an onsite oral presentation However it is not possible to switch and apply for a virtual oral presentation after the submission deadline If you plan to attend the conference virtually you can only apply for a virtual oral presentation as there will be no virtual posters If your abstract is not selected for a virtual oral presentation you can still participate in the conference with access to all the live streamed talks a video library of the recorded talks and a facility to submit questions Only participants attending the event onsite can present a poster Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 735On site PhD Student 635On site Industry 935On site Journal Editors 250Virtual Academia 250Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Christopher Stocks for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Onsite and virtual participants registering to attend are eligible to submit an abstract After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 28 April 2025 in some cases at special rates Please email the hotel directly quoting the booking code BMP25 01 to confirm the exact price of the room Hotel AnlageHotel Vier Jahreszeiten HeidelbergHotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg City ZentrumB B HotelStaycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreHilton HeidelbergMeininger Heidelberg As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference bus schedule Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Rohrbacher Str 22 Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels on a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Neer Tewari Foundation Media partners ChemBioChem a Wiley journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Molecular Medicine an EMBO Press journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Yaw Aniweh, Liliana Mancio-Silva, Wiebke Nahrendorf, Stuart Ralph

18 May - 23 May 2025

Advanced fluorescence imaging techniques

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in mechanisms in cells tissues and developing organisms Invited guest researchers together with microscopy experts from EMBL will foster an intense information flow with a balance of lectures and practical workshops The focus of the course will be on the use of fluorescence microscopy to obtain information about localisation and functions of proteins and other bio molecules at different spatial scales Audience This course is directed towards researchers in the life sciences with access to light microscopy equipment who have an immediate need to apply the techniques they will learn to solve biological problems at the cellular and molecular level in vivo As the course will be primarily focused on the advanced techniques we expect participants to have basic knowledge of light microscopy Modules Resources The topics will include fluorescence microscopy techniques such as fast time lapse microscopy of living cells spinning disk and point scanning confocal microscopy of large 3D samples photo manipulation as a tool multicolour single molecule localization microscopy SMLM with spectral demixing multiplexed imaging expansion microscopy FRET based techniques For demanding applications we will cover the aspects of image processing and analysis and the possibilities of microscope automation The modules will cover all necessary knowledge and demonstrate tools to conduct similar pipelines at your home lab enabling you to answer emerging biological questions This course is organised in cooperation with Evident This course is kindly supported by the EMBL Advanced Light Microscopy Facility Learning outcomes Get an overview of advanced fluorescence imaging techniques Obtain hands on experience setting up and running advanced experiments on modern fluorescence microscopes Discuss the possibilities and drawbacks of experiment planning and data interpretation with experts in the field What past participants say I highly recommend this course if you are looking to take your fluorescence microscopy experiments to the next level Josefina Marin Rojas Universidad de Chile Chile Speakers Speakers trainers and staff Babette van Amen EMBL Heidelberg Germany Steven Coleman VisiTech International UK Joana Delgado Martins University of Zurich Switzerland Claire Deo EMBL Heidelberg Germany Gautam Dey EMBL Heidelberg Germany Yulia Ermakova EMBL Heidelberg Germany Martin Fritsch EMBL Heidelberg Germany Manuel Gunkel EMBL Heidelberg Germany Aliaksandr Halavatyi EMBL Heidelberg Germany Mark Hink University of Amsterdam The Netherlands Marie Jacobovitz EMBL Heidelberg Germany Robert Kasper Evident Germany Muzamil Khan EMBL Heidelberg Germany Simone K hler EMBL Heidelberg Germany Paul Lambert Abbelight France Guy Malkinson Universit de Lorraine France Lucia Pigazzini EMBL Heidelberg Germany Sinem Saka EMBL Heidelberg Germany Markus Sauer University of W rzburg Germany Caterina Severi Abbelight France Caroline Simon EMBL Heidelberg Germany Stefan Terjung EMBL Heidelberg Germany Vishwachi Tripathi EMBL Heidelberg Germany Urs Ziegler University of Zurich Switzerland Anja Zimmermann Rapp OptoElectronic Germany Scientific organisers Joana Delgado Martins University of Zurich Switzerland Manuel Gunkel EMBL Heidelberg Germany Aliaksandr Halavatyi EMBL Heidelberg Germany Stefan Marawske Evident Germany Course organisers Karo Wolkersdorfer Course and Conference Officer EMBL Heidelberg Germany Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLFluorImaging and don t forget to tag EMBLEvents No pre course work will be required Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change The programme is subject to change The bus schedule for the shuttle bus is available here Day 1 Sunday 18 May 2025 TimeDescriptionLocation16 00 16 30Welcome house notes and course overviewISG Hotel Meeting room Weimar16 30 17 30Lecture Concepts in light microscopyUrs Ziegler University of Zurich SwitzerlandISG Hotel Meeting room Weimar17 30 18 00Coffee BreakISG Hotel Meeting room Weimar18 00 19 00Lecture Adaptive feedback microscopyAliaksandr Halavatyi EMBL Heidelberg GermanyISG Hotel Meeting room Weimar19 00 21 00DinnerISG Hotel Restaurant Day 2 Monday 19 May 2025 TimeDescriptionLocation08 40Bus from ISG hotel to EMBL ATC EntranceISG Hotel08 50 09 00Overview of the day and safety briefingCourtyard Room A B09 00 09 55Lecture Expansion microscopyGautam Dey EMBL Heidelberg GermanyCourtyard Room A B09 55 10 40Lecture An Introduction to Image Scanning MicroscopeSteven Coleman VisiTech International UKCourtyard Room A B10 40 11 00Coffee break11 00 12 30Practical Preparation of expansion microscopy samplesCaroline Simon EMBL Heidelberg GermanyBabette van Amen EMBL Heidelberg GermanyMarie Jacobovitz EMBL Heidelberg GermanyLucia Pigazzini EMBL Heidelberg GermanyTraining Lab12 30 13 30LunchEMBL Canteen13 30 13 40Introduction to the practicals13 40 16 10Practical Session 1 Live cell imagingJoana Delgado University of Zurich SwitzerlandSteven Coleman VisiTech International UK Group 1 3D imaging of model organisms with CLSMStefan Terjung EMBL Heidelberg GermanyRobert Kasper Evident Germany Groups 3 4 Imaging expanded samplesGautam Dey EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg Germany Group 2 Microscopy rooms16 10 16 30Coffee break16 30 19 00Practical Session 2 Live cell imagingJoana Delgado University of Zurich SwitzerlandSteven Coleman VisiTech International UK Group 4 3D imaging of model organisms with CLSMStefan Terjung EMBL Heidelberg GermanyRobert Kasper Evident Germany Groups 1 2 Imaging expanded samplesGautam Dey EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg Germany Group 3 Microscopy rooms19 00 21 00Pizza dinner and flash talksRooftop Lounge21 00Departure to HotelATC Entrance Day 3 Tuesday 20 May 2025 TimeDescriptionLocation08 40Bus from ISG hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayComputer Training Lab09 05 10 05Practical Setting and debugging adaptive feedback microscopy pipelinesManuel Gunkel EMBL Heidelberg GermanyComputer Training Lab10 05 11 05Lecture Imaging biological samples using novel and non conventional optical methodsGuy Malkinson Universit de Lorraine FranceCourtyard Room A B11 05 11 30Coffee break group photo11 30 12 30Discussion round Techniques for imaging model organismsStefan Terjung EMBL Heidelberg GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 13 40Introduction to the practicals13 40 16 10Practical Session 3 Live cell imagingJoana Delgado University of Zurich SwitzerlandSteven Coleman VisiTech International UK Group 2 DeconvolutionUrs Ziegler University of Zurich SwitzerlandMartin Fritsch EMBL Heidelberg Germany Groups 3 4 Imaging expanded samplesGautam Dey EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg Germany Group 1 Microscopy rooms Computer Training Lab16 10 16 30Coffee break16 30 19 00Practical Session 4 Live cell imagingJoana Delgado University of Zurich SwitzerlandSteven Coleman VisiTech International UK Group 3 DeconvolutionUrs Ziegler University of Zurich SwitzerlandMartin Fritsch EMBL Heidelberg Germany Groups 1 2 Imaging expanded samplesGautam Dey EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg Germany Group 4 Microscopy rooms Computer Training Lab19 00 21 00Tapas dinner and flash talksRooftop Lounge21 00Departure to HotelATC Entrance Day 4 Wednesday 21 May 2025 TimeDescriptionLocation08 40Bus from ISG hotel to EMBL ATC EntranceISG Hotel09 00 09 50Lecture Introduction to SMLM from concepts to samplesCaterina Severi Abbelight FranceCourtyard Room A B09 50 10 50Lecture A DNA toolbox for spatial biologySinem Saka EMBL HeidelbergCourtyard Room A B10 50 11 10Coffee break11 10 11 40Lecture Photomanipulation techniques and applicationsAnja Zimmermann Rapp OptoElectronic GmbHCourtyard Room A B11 40 12 30Lecture Measuring interactions and biosensors using FRETMark Hink University of Amsterdam The NetherlandsCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 13 40Introduction to the practicals13 40 16 10Hands on Practical Session 5 Multicolor Single molecule Localization Microscopy with Spectral DemixingCaterina Severi Abbelight FranceManuel Gunkel EMBL Heidelberg Germany Group 2 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within TissuesYulia Ermakova EMBL Heidelberg GermanyMuzamil Khan EMBL Heidelberg GermanyVishwachi Tripathi EMBL Heidelberg Germany Group 1 FRETMark Hink University of Amsterdam The NetherlandsStefan Terjung EMBL Heidelberg Germany Group 4 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyAnja Zimmermann Rapp OptoElectronic GmbH Germany Group 3 Microscopy rooms16 10 16 30Coffee break16 30 19 00Hands on Practical Session 6 Multicolor Single molecule Localization Microscopy with Spectral DemixingCaterina Severi Abbelight FranceManuel Gunkel EMBL Heidelberg Germany Group 4 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within TissuesYulia Ermakova EMBL Heidelberg GermanyMuzamil Khan EMBL Heidelberg GermanyVishwachi Tripathi EMBL Heidelberg Germany Group 3 FRETMark Hink University of Amsterdam The NetherlandsStefan Terjung EMBL Heidelberg Germany Group 2 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyAnja Zimmermann Rapp OptoElectronic GmbH Germany Group 1 Microscopy rooms19 00 19 45Departure to downtown via ISGATC Entrance19 45 22 00Dinner downtownOskar Restaurant Vinothek Day 5 Thursday 22 May 2025 TimeDescriptionLocation08 40Bus from ISG hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Lecture Visualizing chromosomes during meiosisSimone K hler EMBL Heidelberg GermanyCourtyard Room A B10 05 11 05Lecture Small molecule fluorophores for biological imagingClaire Deo EMBL Heidelberg GermanyCourtyard Room A B11 05 11 30Coffee break11 30 12 30Lecture True molecular resolution imaging Fluorescence imaging with a spatial resolution in the one digit nanometer rangeMarkus Sauer University of W rzburg GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 13 40Introduction to the practicals13 40 16 10Hands on Practical Session 7 Multicolor Single molecule Localization Microscopy with Spectral DemixingCaterina Severi Abbelight FranceManuel Gunkel EMBL Heidelberg Germany Group 1 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within TissuesYulia Ermakova EMBL Heidelberg GermanyMuzamil Khan EMBL Heidelberg GermanyVishwachi Tripathi EMBL Heidelberg Germany Group 2 FRETMark Hink University of Amsterdam The NetherlandsStefan Terjung EMBL Heidelberg Germany Group 3 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyAnja Zimmermann Rapp OptoElectronic GmbH Germany Group 4 Microscopy rooms16 10 16 30Coffee break16 30 19 00Hands on Practical Session 8 Multicolor Single molecule Localization Microscopy with Spectral DemixingCaterina Severi Abbelight FranceManuel Gunkel EMBL Heidelberg Germany Group 3 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within TissuesYulia Ermakova EMBL Heidelberg GermanyMuzamil Khan EMBL Heidelberg GermanyVishwachi Tripathi EMBL Heidelberg Germany Group 4 FRETMark Hink University of Amsterdam The NetherlandsStefan Terjung EMBL Heidelberg Germany Group 1 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyAnja Zimmermann Rapp OptoElectronic GmbH Germany Groups 2 Microscopy rooms19 00 20 00DinnerEMBL Canteen20 00Departure to HotelATC Entrance Day 6 Friday 23 May 2025 TimeDescriptionLocation08 40Bus from ISG hotel to EMBL ATC EntranceISG Hotel09 00 10 30Practical FRET data analysisMark Hink University of Amsterdam The NetherlandsComputer training lab10 30 11 00Coffee break11 00 12 30Practical SMLM data analysisCaterina Severi Abbelight FranceManuel Gunkel EMBL Heidelberg GermanyComputer training lab12 30 13 30LunchEMBL Canteen13 30 15 00Preparation of student presentationsComputer training lab15 00 16 30Student presentationsComputer training lab16 30 17 00Wrap up of course and departureComputer training lab17 15Bus to ISG Hotel Heidelberg train station and city centerATC Entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 625 00PhD Student 625 00Industry 1 150 00 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation Single rooms have been reserved for 6 nights from Saturday 17 May 2025 to Friday 23 May 2025 at the ISG hotel Im Eichwald 19 69126 Heidelberg After the selection process selected participants should contact the hotel directly to make a booking with a booking code EVA25 01 by the deadline of Wednesday 16 April 2025 We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule can be found here course shuttle timetable Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Course partners Course sponsors Media partners Microscopy and Analysis a Wiley journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Data resources...

Manuel Gunkel, Aliaksandr Halavatyi, Joana Delgado Martins, Stefan Marawske

14 May 2025

Principles of research data management

Description In today s data rich research environment good data management isn t just about storage it s about enabling collaboration reproducibility and long term value This webinar introduces fundamental principles behind academic data management We will describe the research data lifecycle explore how data moves through typical research workflows common challenges in handling it and strategies for organising documenting and sharing data responsibly Regardless of your research area these foundational principles are becoming increasingly important whether you re working with small spreadsheets or high throughput instruments and understanding them can help you build a more robust and transparent data flow for your projects...

13 May - 16 May 2025

Chromatin and epigenetics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Epigenetics refers to heritable changes in gene expression that do not involve changes to the underlying DNA sequence At least three systems including DNA methylation histone modifications and non coding RNAs ncRNA are considered to play fundamental roles in epigenetic regulation Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases Moreover influence of age environment lifestyle and disease state on epigenetic states is being increasingly appreciated and actively studied This conference provides an international forum for cutting edge research in chromatin and epigenetics It provides the focal hub for scientists to present their research and exchange ideas Renowned speakers will cover the latest advances in the field Session topics Heterochromatin Developmental epigenetics Chromatin regulation and disease Nucleosomes structure and function Transcription and chromatin Nuclear architecture Chromatin and RNA modifications Single cell genomics and advanced microscopy Impact of age environment and lifestyle on epigenetic state What past participants say about the conference The conference was very thoughtfully organised and the subject matter allowed me to deepen my knowledge on many interesting levels It was a valuable experience that I would like to repeat in the future Magdalena University of Lodz Poland The training provided by EMBL was very fruitful and productive I would like to be a part of such training in future too and also like to recommend others to be part of it Dr Laxman Khanal BPKIHS Nepal Although online this conference was well organised with an overall great quality of talks about many novelties If I can I will definitely attend the next time maybe already on site Tobias Hohl Max Planck Institute of Immunology and Epigenetics Germany Speakers Karen Adelman Harvard Medical School USA Stein Aerts KU Leuven Belgium Adrian Bird The University of Edinburgh UK Aydan Bulut Karslioglu Max Planck Institute for Molecular Genetics Germany Howard Chang Stanford University School of Medicine USA Joseph R Ecker Salk Institute for Biological Studies USA Anja Groth University of Copenhagen Denmark Petra Hajkova MRC Laboratory of Medical Sciences UK Nicola Iovino Max Planck Institute of Immunobiology and Epigenetics Germany Stefan Mundlos Max Planck Institute for Molecular Genetics Germany Geeta Narlikar University of California San Francisco USA Jennifer Phillips Cremins University of Pennsylvania USA Ali Shilatifard Northwestern University Feinberg School of Medicine USA Alexander van Oudenaarden Hubrecht Institute The Netherlands Wei Xie Tsinghua University China Bing Zhu Institute of Biophysics Chinese Academy of Sciences China Xiaowei Zhuang Harvard University USA Scientific organisers Asifa Akhtar Max Planck Institute of Immunobiology and Epigenetics Germany Amanda Fisher University of Oxford UK Bing Ren University of California San Diego USA Dirk Sch beler Friedrich Miescher Institute for Biomedical Research Switzerland Conference organiser Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLChromatin and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here The bus schedule for this conference is available here Day 1 Tuesday 13 May 2025 Time Europe Berlin Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 18 00Session 1 Chromatin accessibility and DNA methylationChair Asifa Akhtar Max Planck Institute of Immunobiology and Epigenetics Germany13 45 14 15SALL4 as an interpreter of DNA base compositionAdrian Bird The University of Edinburgh UKNot available on demand14 15 14 45Human body single cell atlas of 3D genome organization and DNA methylationJoseph R Ecker Salk Institute for Biological Studies USA14 45 15 00Role for components of maize RNA directed DNA methylation pathway in maintaining repressive modificationsMaike Stam SILS University of Amsterdam Netherlands15 00 15 15DNA methylation interplays with RNA m6A factors to establish heritable epigenetic silencing in human cellsJames Nu es University of California USANot available on demand15 15 15 30The basic domain of Suv39h2 protects the RNA nucleosome scaffold at mouse heterochromatin Kalina Swist Rosowska Max Planck Institute of Immunobiology and Epigenetics Germany15 30 16 15Coffee Break and Meet the speakers16 15 16 45Cancer genes beyond chromosomesHoward Chang Stanford University School of Medicine USANot available on demand16 45 17 15Controlling CpG islandsDirk Sch beler Friedrich Miescher Institute for Biomedical Research SwitzerlandNot available on demand17 15 17 30Dissect the silencing and pathogenic mechanisms of retrotransposons in tissue regenerationYejing Ge MD Anderson Cancer Center USA17 30 17 45Delineating the roles of retrotransposons in human placental development and disorderLin Gao Hong Kong University of Science and Technology Hong Kong17 45 19 00Poster sneak peek19 00 21 00Dinner in Canteen21 00 22 30Pub Quiz in Canteen Day 2 Wednesday 14 May 2025 Time Europe Berlin Speaker09 00 12 15Session 2 Epigenetics and developmentChair Petra Hajkova MRC Laboratory of Medical Sciences UK09 00 09 30Deciphering the genomic basis of wing development in batsStefan Mundlos Max Planck Institute for Molecular Genetics Germany09 30 10 00Passage of epigenetic information in the context of the germ linePetra Hajkova MRC Laboratory of Medical Sciences UKNot available on demand10 00 10 15DNA replication and cell fate transitionsConstance Alabert University of Dundee UK10 15 10 45Coffee Break and Meet the speakers10 45 11 15Epigenetic mechanisms of pluripotency maintenance and exitAydan Bulut Karslioglu Max Planck Institute for Molecular Genetics GermanyNot available on demand11 15 11 45Decoding the transcription circuitry when the life beginsWei Xie Tsinghua University China11 45 12 00Transcription factors and chromatin remodelers in eye development and retinal diseasesRuth Ashery Padan Tel Aviv University IsraelNot available on demand12 00 12 15Poising and connectivity of human emergent developmental enhancers in the transition from na ve to primed pluripotencyMikhail Spivakov MRC Laboratory of Medical Sciences and Imperial College London UK12 15 13 45Lunch and Meet the Editors13 45 16 15Session 3 Transcription control and disease statesChair Amanda Fisher University of Oxford UK13 45 14 15Molecular insight into transcription elongation regulatory mechanisms and epigenetics deliver critical targets for cancer therapeuticsAli Shilatifard Northwestern University Feinberg School of Medicine USANot available on demand14 15 14 30A conserved switch to catalytically inactive Polycomb complexes in non dividing cellsEvan Healy Monash University Australia14 30 14 45A genome wide code to define cell type specific CTCF binding and chromatin organizationJane Skok NYU Langone Health USA14 45 15 15Epigenetic regulation by histone acetylationAsifa Akhtar Max Planck Institute of Immunobiology and Epigenetics GermanyNot available on demand15 15 15 45Coffee Break and Meet the speakers15 45 16 15Modeling genome to functionStein Aerts KU Leuven Belgium16 15 16 30Flash talk session 1 135 Shubhangini Kataruka 136 Upneet Kaur 157 Luca Mariani 163 Sabrina Mazzucchi16 30 18 00Poster Session 1 odd numbers 18 00Free evening Day 3 Thursday 15 May 2025 Time Europe Berlin Speaker09 00 12 00Session 4 Epigenetic memoryChair Wei Xie Tsinghua University China09 00 09 30Epigenetic cell memory how cells copy their epigenomeAnja Groth University of Copenhagen DenmarkNot available on demand09 30 10 00Mechanisms of heterochromatin regulationBing Zhu Chinese Academy of Sciences China10 00 10 15Single cell multimodal chromatin profiling using S3Nano CUT Tag reveals regulatory dynamics during embryogenesisBaekgyu Kim EMBL Heidelberg Germany10 15 10 45Coffee Break and Meet the speakers10 45 11 15Epigenetic inheritance and cell divisionAmanda Fisher University of Oxford UK11 15 11 45Auto inhibition imposed by a large conformational switch of INO80 regulates nucleosome positioningGeeta Narlikar University of California San Francisco USA11 45 12 00Separating the catalytically dependent and independent roles of chromatin modifiers in mouse developmentCatrin Teleri Lloyd EMBL Rome ItalyNot available on demand12 00 13 30Lunch13 30 16 45Session 5 Genome organisation and functionChair Dirk Sch beler Friedrich Miescher Institute for Biomedical Research Switzerland13 30 14 00Novel multi omics approaches to monitor epigenetics in single cellsAlexander van Oudenaarden Hubrecht Institute The Netherlands14 00 14 30Dissecting the genome s structure function relationship during neural circuit stimulationJennifer Phillips Cremins University of Pennsylvania USA14 30 14 45The DOMINO TIP60 complex in Drosophila A lubricator of proliferationPeter Becker LMU Munich Germany14 45 15 00MORC2 is a DNA compaction machineShabih Shakeel University of Melbourne Australia15 00 15 30Coffee Break and Meet the speakers15 30 16 00Epigenetic inheritanceNicola Iovino Max Planck Institute of Immunobiology and Epigenetics GermanyNot available on demand16 00 16 15Characterizing the effects of regulatory variation in the human brain through single cell multiomics and whole genome sequencingOlga Sigalova VIB AI Center for AI and Computational Biology16 15 16 30Mechanism of cohesin release and control of 3D genome folding by cellular ligandsDaniel Panne University of Leicester UK16 30 16 45Structure of the nucleosome bound human BCL7AElisa Bergamin CERBM GIE IGBMC France16 45 17 00Flash talk session 2 56 Lucia Barbadilla Martinez 62 Anupam Bhoi 112 Agnese Loda17 00 18 30Poster Session 2 even numbers 18 30 20 30Conference dinner in the canteen20 30 23 30Party Day 4 Friday 16 May 2025 Time Europe Berlin Speaker09 00 11 45Session 6 Chromatin and transcriptional dynamicsChair Nicola Iovino Max Planck Institute of Immunobiology and Epigenetics Germany09 00 09 30Spatially resolved single cell transcriptomics epigenomics 3D genome mapping and functional genomicsXiaowei Zhuang Harvard University USANot available on demand09 30 09 45Genome organization and function around the nucleolus Raffaella Santoro University of Zurich Switzerland09 45 10 00Biomolecular condensates at the nuclear pore basket maintain global chromatin organization Charlene Boumendil University of Montpellier FranceNot available on demand10 00 10 30Coffee Break and Meet the speakers10 30 10 45Chromatin remodeling activity of ChAHP associated CHD4 is required to repress SINE B2 elementsJosip Ahel Friedrich Miescher Institute for Biomedical Sciences Switzerland10 45 11 00The PNUTS phosphatase complex controls transcription pause releaseEmilia Dimitrova University of Oxford UK11 00 11 15SMCHD1 compacts DNA directly in an ATP independent mannerShifeng Xue National University of Singapore Singapore11 15 11 45Control of transcription elongation across the chromatin templateKaren Adelman Harvard Medical School USA11 45 12 00Closing Remarks and Poster Prize Announcements12 00Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 800On site PhD Student 700On site Industry 1000On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Luana Ribeiro for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact luana ribeiro embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 11 April 2025 in some cases at special rates Please email the hotel directly quoting the booking code CHR25 01 to confirm the exact price of the room Hotel AnlageHotel Holl nder Hof Hotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg City ZentrumB B HotelISG Hotel Staycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreHilton HeidelbergMeininger HeidelbergHotel Vier Jahreszeiten Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsorsActive Motif BMKGENE Epigenome TechnologiesEvent supporter Media partnersAdvanced Biology a Wiley journal Advanced Genetics a Wiley journal BioEssays a Wiley journal Cancer Drug Resistance an OAE Publishing Inc journal ChemBioChem a Wiley journal Current Opinion in Genetics Development an Elsevier journal Genes and Development a Cold Spring Harbor journal Genome Research a Cold Spring Harbor journal Development The Company of Biologists journal EMBO Reports an EMBO Press journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9PPT Slide 16 9 Leaderboard 728 90...

Asifa Akhtar, Amanda Fisher, Dirk Schubeler, Bing Ren

12 May - 16 May 2025

Cancer genomics and transcriptomics

Description This course will focus on the analysis of data from genomic studies of cancer It will also highlight the application of transcriptomic analysis and single cell technologies in cancer Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 08 45 17 30 BST each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Anca Belu

8 May 2025

Navigating UniProt: a brief overview and recent updates

Description Join us for an engaging webinar that will guide you through the new and enhanced features and functionalities of the UniProt website Designed with user experience at the forefront the website offers seamless access to the comprehensive data provided by the UniProt consortium In this session we will walk you through the structure of the UniProt website and highlight key improvements including new data integrations and enhanced visualisations We will also introduce you to our updated feature viewer which now incorporates data from multiple sources such as PTMs from large scale data epitopes RNA editing and AlphaMissense predictions We will explore the different methods for downloading data and guide you on choosing the right one based on your specific needs...

6 May - 9 May 2025

Theory and concepts in biology

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Recent progress in biology has led to an explosion of factual knowledge about the living world over a huge range of scales in space and time Yet many questions about how to make sense of this data remain across the entire diversity of the living world from the smallest bacterium to the ecosystems of the Serengeti This meeting is the 2nd edition in a series of symposia aiming to bring together a diverse community of researchers interested in finding ways to transform into conceptual knowledge the ever increasing amount of factual knowledge produced by biological research The goal is to provide a platform to discuss perspectives on the role of theory in biology and importantly also vice versa the impact that biology can have on theory Session topics Biologically active matter Cellular information processing Memory and learning Organismal behaviour Mechanics and morphogenesis Spatial ecology Living dynamical systems Emerging concepts What past participants say about the Symposium Intense discussions on theory in biology interactions between the mainstream and the interface outstanding science brilliantly presented the intellectual openness and warmth of the organising committee and a superb conference office team combined to create a memorable meeting Thank you Sriram Ramaswamy Indian Institute of Science India As a sophomore PhD student with a background in physics I had a wonderful opportunity to engage with various individuals and learn from them particularly biologists Prior to the conference I had certain questions concerning the biological aspects of my project and now I have gained a better understanding Kartik Chhajed Max Planck Institute for the Physics of Complex Systems Germany Speakers Karen Alim Technical University of Munich Germany Anne Florence Bitbol EPFL Switzerland Daniel Fisher Stanford University USA Hernan Garcia University of California Berkeley USA Daniel Goldman Georgia Institute of Technology USA Isabella Graf EMBL Heidelberg Germany Jeremy Gunawardena Harvard Medical School USA Virtual speaker Vishwesha Guttal Centre for Ecological Sciences Indian Institute of Science India Virtual speaker Elena Koslover University of California San Diego USA Arvind Murugan University of Chicago USA Madan Rao National Centre for Biological Sciences India Virtual speaker Pablo Sartori Gulbenkian Institute Portugal Agnese Seminara University of Genoa Italy Greg Stephens Vrije Universiteit Amsterdam The Netherlands Virginie Uhlmann University of Zurich Switzerland Renske Vroomans University of Cambridge UK Hepeng Zhang Shanghai Jiao Tong University China Scientific Organisers Alexander Aulehla EMBL Heidelberg Germany Jordi Garcia Ojalvo Pompeu Fabra University UPF Spain Christina Hueschen University of California San Diego USA Sriram Ramaswamy Indian Institute of Science India Kirsty Wan University of Exeter UK Conference Organiser Charlotte Courtney EMBL Heidelberg Germany Iva Gavran EMBL Heidelberg Germany Programme Are you on social media Post using EESTCBio and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Conference bus schedule Day 1 Tuesday 6 May 2025 Time Europe Berlin Speaker12 00 13 30Arrival and registration with light refreshments13 30 13 45Opening remarks13 45 16 45Session 1Chair Marta Iba es Universitat de Barcelona Spain13 45 14 15Impact of complex spatial population structures on biological evolutionAnne Florence Bitbol EPFL Switzerland14 15 14 30Tissue scale membrane depolarization upon organ injury allows for fast tracked regenerationJinghui Liu Center for Systems Biology Dresden Max Planck Institute for Physics of Complex Systems Germany14 30 15 00The role of evolutionary simulations in the theory of noveltyRenske Vroomans University of Cambridge UK15 00 15 30Coffee Break and Meet the speakers with Anne Florence Bitbol and Renske Vroomans15 30 16 00Systems biology 2 0 completing the information revolution in biologyJeremy Gunawardena Harvard Medical School USAVirtual talk16 00 16 15Physics of phase separation inside biological cellsDavid Zwicker Max Planck Institute for Dynamics and Self Organization Germany16 15 16 30Biophysical modeling reveals how post translational modifications govern pyrenoid dynamics during fissionAlessandra Lucchetti University of Copenhagen Denmark16 30 16 45Condensate formation DNA repair and oscillations in cell dynamicsMogens Jensen University of Copenhagen Denmark16 45 17 00The physical consequences of sperm gigantismBrato Chakrabarti International Center for Theoretical Sciences India17 00 17 30Coffee break 17 30 18 30Group discussions 118 30 19 30Vegetarian dinner in EMBL canteen19 30 21 00After dinner drinks in the ATC Rooftop lounge Day 2 Wednesday 7 May 2025 Time Europe Berlin Speaker8 45 9 00Arrival and coffee09 00 12 00Session 2Chair Chair David Zwicker Max Planck Institute for Dynamics and Self Organization Germany09 00 09 30Transport and exchange in dynamic mitochondrial networksElena Koslover University California San Diego09 30 09 45Conceptual foundations of comparative biologyJames DiFrisco Francis Crick Institute United Kingdom09 45 10 00How curvature and apical tilt determine the motion of malaria parasites a theoretical experimental studyLeon Lettermann Heidelberg University Germany10 00 10 30Coffee Break and Meet the speakers with Elena Koslover10 30 11 00The role of finite size stochasticity in ecological systems from animal groups to populations to evolutionVishwesha Guttal Indian Institute of Science IndiaNot available on demandVirtual talk11 00 11 15How does a finger get its knuckles Reaction diffusion models in the tetrapod limb and beyondTom Hiscock University of Aberdeen United Kingdom11 15 11 45Critical points in sensing and decision makingIsabella Graf EMBL Heidelberg Germany11 45 12 00Dynamic formation of condensates enhances the circadian clockRenyu Wang Peking University China12 00 13 30Lunch 13 30 17 30Session 3Chair Tamar Friedlander Hebrew University of Jerusalem Israel13 30 14 00Life at low coasting numberDaniel Goldman Georgia Institute of Technology USA14 00 14 15Beyond Arrhenius Mechanistic origins of temperature scaling in embryonic developmentLendert Gelens KU Leuven Belgium14 15 14 30A minimal mechanical model for Clytia hemisphaerica regenerationAnne Materne Max Planck Institut f r molekulare Zellbiologie und Genetik Germany14 30 15 00Coffee Break and Meet the speakers with Vishwesha Guttal Isabella Graf and Daniel Goldman15 00 16 30Woodland walk and group discussions 2 while walking 16 30 17 00Using physics as a microscope to dissect transcriptional dynamics in developmentHernan Garcia University of California Berkeley USA17 00 17 30Flash talk session 1 odd numbers Poster numbers 37 39 41 45 47 53 57 59 63 67 69 71 73 76 77 85 87 91 95 97 10117 30 19 00Poster Session 1 odd numbers with drinks and snacks19 00 20 00Dinner in EMBL Canteen Day 3 Thursday 8 May 2025 Time Europe Berlin Speaker8 45 9 00Arrival and coffee09 00 12 00Session 4Chair Mogens Jensen University of Copenhagen Denmark09 00 09 30Chiral active matterHepeng Zhang Shanghai Jiao Tong University China09 30 09 45Reconciling conflicting selection pressures in the plant self incompatibility systemTamar Friedlander Hebrew University of Jerusalem Israel09 45 10 00Associative memory in human cancer cellsSt phane Dayot Gustave Roussy France10 00 10 30Coffee Break and Meet the speakers with Hernan Garcia and Hepeng Zhang10 30 11 00Communication via fluid flowKaren Alim Technical University of Munich GermanyNot available on demand11 00 11 15Physics Lessons from Worms How a collective behavior in C elegans revealed that organisms see water flow through electromagnetic cuesLaura Persson University of California San Francisco USA11 15 11 45Decoding encoding of molecular information global optimization and the geometry of inferenceMadan Rao National Centre for Biological Sciences IndiaVirtual talk11 45 12 00A diffusion driven switch theory and experimentsMarta Iba es Universitat de Barcelona Spain12 00 13 30Lunch13 30 17 30Session 5Chair Sophie de Buyl Vrije Universiteit Brussel Belgium13 30 14 00Semantic self assembly in a meaning less energy landscapePablo Sartori Gulbenkian Institute PortugalNot available on demand14 00 14 15Inference of planarian life history strategies from organismal scale single cell transcriptomicsAmrutha Palavalli EMBL Heidelberg Germany14 15 14 45Octopus inspired multi agent prediction and navigation in a turbulent environmentAgnese Seminara University of Genoa Italy14 45 15 15Coffee Break and Meet the speakers with Karen Alim Pablo Sartori and Agnese Seminara15 15 16 15Group discussions 316 15 16 45Neural computation through learned phase diagramsArvind Murugan University of Chicago USA16 45 17 00Anisotropic stretch biases the self organization of actin fibers in multicellular hydra aggregatesAnais Bailles Max Planck Institute of Molecular Cell Biology and Genetics Germany17 00 17 30Flash talk session 2 even numbers Poster numbers 38 40 50 52 54 56 58 60 62 68 72 74 78 80 82 84 88 90 92 96 10017 30 19 00Poster Session 2 even numbers with drinks and snacks19 00 20 30Conference dinner in the canteen20 30 23 00Party in the ATC Rooftop lounge Day 4 Friday 9 May 2025 Time Europe Berlin Speaker8 45 9 00Arrival and coffee09 00 12 15Session 6Chair Lendert Gelens KU Leuven Belgium09 00 09 30Chaotic worms from the dynamics of animal behavior towards a physics of complex evolved systemsGreg Stephens Vrije Universiteit Amsterdam OIST Graduate University The Netherlands09 30 10 00Unsupervised exploration of biological morphology in microscopy imagesVirginie Uhlmann University of Zurich SwitzerlandNot available on demand10 00 10 30Coffee Break and Meet the speakers with Daniel Fisher Greg Stephens Virginie Uhlmann and Arving Murugan10 30 11 15Group presentations11 15 11 30Gradient versus geometrical encoding of information for cell fate decision in early embryogenesisSophie de Buyl Vrije Universiteit Brussel Belgium11 30 11 45Genome scale selection an alternative perspective on large scale evolutionary dynamicsAedan Brown Boston University United States of America11 45 12 15Perpetual evolution and diversification driven by ecological feedbackDaniel Fisher Stanford University USA12 15 12 30Closing remarks and Poster prize announcements12 30 12 45Packed lunch and departure12 45Airport shuttle bus from EMBL ATC to Frankfurt airport Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site PhD Student 625On site Academia 725On site Industry 925On site Journal Editor 300Virtual PhD Student 175Virtual Academia 225Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Iva Gavran for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 8 April 2025 in some cases at special rates Please email the hotel directly quoting the booking code EES25 03 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityB B HotelMeininger HeidelbergStaycity Aparthotel HeidelbergExzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference bus schedule Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels on a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen Sie How are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page Sponsors Event supporter Media partners ChemBioChem a Wiley journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal The EMBO Journal an EMBO Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Alexander Aulehla, Christina Hueschen, Jordi Garcia-Ojalvo, Sriram Ramaswamy, Kirsty Wan

4 May - 9 May 2025

Analysis and integration of transcriptome and proteome data

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells tissues and organisms operate in their biological context Among the key technologies driving this forward are next generation sequencing and proteomics as they provide powerful means to determine global expression levels of genes and proteins Both fields have matured to a degree that they have now become accessible to researchers in many areas of biology During this course participants will gain theoretical insight in the structure of sequencing and proteomic data and they will receive training in data analysis for the annotation quantification and statistical analysis of gene and protein expression using various computational tools In addition training will be provided in the use of Cytoscape to derive biological insights from the integration of both data types Audience This course is targeted at biologists and biochemists who are starting to be involved in both next generation sequencing and mass spectrometry based proteomics but who are not experts in these fields Learning outcomes The aim of this practical course is to provide insight in techniques that are frequently used for transcriptome and proteome analysis and to provide hands on experience turning primary data into information that can be used for further biological interpretation To achieve these goals participants will gain insight in the basic principles of gene expression analysis RNAseq data quantification and differential expression analysis protein identification and quantification and they will be trained in the use of software tools to analyse sequencing and proteomic data SearchGUI PeptideShaker MaxQuant In addition the course will provide insight in the complementarity of transcriptome and proteome data by their integrative analysis via Cytoscape What past participants say about the course Besides of the amazing content provided by distinguished speakers participants with diverse scientific backgrounds broadened our perspectives and created a nourishing scientific environment We were able to learn key aspects of integrating omics data to our research and benefited from networking opportunities Overall it was a really nice experience Damla Gunes Ko University Turkey The analysis and integration of transcriptome and proteome data course organized by EMBL allowed me to expand my horizons regarding the various bioinformatic tools and statistical analysis available that we can use for our transcriptome and proteomic Highly Recommended Diogo Est v o i3S Institute for Research and Innovation in Health CRIG Cancer Research InstituteGhent Belfium Speakers Speakers trainers and staff Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Hyungwon Choi National University of Singapore Singapore Daria Fijalkowska University of Ghent Belgium Jeroen Krijgsveld German Cancer Research Centre DKFZ Germany Manjeet Kumar EMBL Heidelberg Germany Lennart Martens VIB University of Ghent Belgium Gerben Menschaert University of Ghent Belgium Scooter Morris University of California San Francisco USA Jan Provaznik EMBL Heidelberg Germany Maria Luisa Ratto University of Turin Italy Santhust EMBL Heidelberg Germany Scientific organisers Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Daria Fijalkowska University of Ghent Belgium Jeroen Krijgsveld German Cancer Research Centre DKFZ Germany Lennart Martens VIB University of Ghent Belgium Course organisers Maria Mercedes Bacadare Goitia Course and Conference Team Lead EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBLDataIntegration and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course The below programme is still subject to changes Day 1 Sunday 4 May 2025 Time Europe Berlin SessionLocation09 00 09 15Arrival welcome and safety introductionsCourtyard room09 15 11 00Lecture RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard room11 00 11 30Coffee breakATC Foyer11 30 12 30RNAseq Reads to genesRaffaele Calogero University of Turin ItalyJan Provaznik EMBL Heidelberg GermnayMaria Luisa Ratto University of Turin ItalyCourtyard room12 30 13 30LunchEMBL Canteen13 30 16 00Practical From Reads to GenesRaffaele Calogero University of Turin ItalyJan Provaznik EMBL Heidelberg GermnayMaria Luisa Ratto University of Turin ItalyComputer Training Lab16 00 16 30Coffee breakCourtyard room16 30 18 00Q A on RNAseqComputer Training Lab18 00 19 30Dinner EMBL Canteen19 30Departure to Premier Inn HotelATC entrance Day 2 Monday 5 May 2025 Time Europe Berlin SessionLocation09 00 10 00Flash talk presentationsCourtyard room10 00 12 30Practical theory Differential expression analysis Raffaele Calogero University of Turin ItalyJan Provaznik EMBL Heidelberg GermnayMaria Luisa Ratto University of Turin Italywith flexible coffee breakComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Lecture Ribosome profilingGerben Menschaert University of Ghent BelgiumCourtyard room16 00 16 30Coffee breakCourtyard room16 30 18 30Practical Session Ribosome profilingGerben Menschaert University of Ghent BelgiumComputer Training Lab18 30 19 30Pizza DinnerRooftop lounge19 30Departure to Premier Inn HotelATC entrance Day 3 Tuesday 6 May 2025 Time Europe Berlin SessionLocation09 00 10 00Introduction to ProteomicsJeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab10 00 11 00Practical peptide and protein identificationJeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab11 00 11 30Coffee breakComputer Training Lab11 30 12 00Practical peptide and protein identification continued Jeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab12 00 12 30DDA and DIA what is the difference and why does it matter Jeroen Krijgsveld German Cancer Research Centre DKFZ GermanyCourtyard room12 30 13 30LunchEMBL Canteen13 30 15 00Lecture Bioinformatics for proteomicsLennart Martens University of Ghent BelgiumCourtyard room15 00 16 00Q A to Bioinformatics for proteomicsLennart Martens University of Ghent BelgiumCourtyard room16 00 16 30Coffee BreakComputer Training Lab16 30 18 00Practical Session Turning data into information peptide and protein identification database searchingLennart Martens University of Ghent Belgiumwith flexible coffee breakComputer Training Lab18 00 19 00DinnerEMBL Canteen19 00Departure to Premier Inn HotelATC entrance Day 4 Wednesday 7 May 2025 Time Europe Berlin SessionLocation09 00 10 00Lecture Introduction to DIA proteomics data analysisDaria Fijalkowska University of Ghent BelgiumCourtyard room10 00 10 30Coffee breakComputer Training Lab10 30 12 00Practical Session DIA proteomics data analysisDaria Fijalkowska University of Ghent BelgiumComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Practical Session Quantitative proteomics data interpretationDaria Fijalkowska University of Ghent BelgiumComputer Training Lab14 30 16 15Lecture P values and multiple testing correctionHyungwon Choi National University of Singapore SingaporeCourtyard room16 15 17 00GeneCore Facility TourGeneCore17 00Free afternoon17 00Departure to Premier Inn HotelATC entrance Day 5 Thursday 8 May 2025 Time Europe Berlin SessionLocation09 00 10 00Q A to Bioinformatic tools for data comparison and integrationJohn Scooter Morris University of California San Francisco USACourtyard room10 00 10 30Coffee breakComputer Training Lab10 30 12 30Practical Introduction to CytoscapeManjeet Kumar EMBL Heidelberg GermanyJohn Scooter Morris University of California San Francisco USAComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 00Practical Introduction to CytoscapeManjeet Kumar EMBL Heidelberg GermanyJohn Scooter Morris University of California San Francisco USAComputer Training Lab15 00 16 15Practical Introduction to CytoscapeManjeet Kumar EMBL Heidelberg GermanyJohn Scooter Morris University of California San Francisco USAComputer Training Lab16 15 16 45Coffee breakComputer Training Lab16 45 17 45Application talk Network oriented integrative multi omics analysis of tissues and fluids case studies in cancer and cardiovascular diseasesHyungwon Choi National University of Singapore SingaporeCourtyard room17 45 18 15Departure to Premier Inn Hotel and Neckarm nzplatzATC entrance18 15 22 25Downtown Dinner Day 5 Friday 9 May 2025 Time Europe Berlin SessionLocation09 00 12 00Practical Session Data integrationJohn Scooter Morris University of California San Francisco USAwith flexible coffee breakComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 15 00Practical Session Data integrationJohn Scooter Morris University of California San Francisco USAComputer Training Lab15 00 15 30Course wrap up and farewellComputer Training Lab15 30Departure to Heidelberg train stationATC entrance Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 750PhD Student 750Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 5 nights from Saturday 3 until Friday 9 May at the Premier Inn Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code PRO25 01 by the deadline of Friday 28 March We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights from Saturday 3 May until Friday 9 May at the Premier Inn hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code PRO25 01 by the deadline of Wednesday 2 April 2025 We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Raffaele Calogero, Daria Fijalkowska, Jeroen Krijgsveld, Lennard Martens

29 April 2025

Sustainable research: fit for the future

Description Overview Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview The symposium will delve into the critical role of sustainable practices within the scientific community As researchers grapple with global challenges it becomes imperative to adopt environmentally responsible and socially equitable research methodologies This symposium will explore topics such as green laboratory practices the inspiring role of grassroots movements organisation s sustainability strategies and the vital role of funders always with an eye on the future By fostering a culture of sustainability within science we can reduce our ecological footprint enhance research integrity and ensure the long term viability of scientific research Through a series of keynote presentations panel discussions and interactive workshops participants will have the opportunity to engage with leading experts and share their own experiences in sustainable science By fostering interdisciplinary collaboration and knowledge sharing this event aims to inspire scientists to embrace sustainability as a core principle of their work This symposium is being hosted at EMBL Heidelberg and virtually as part of the SuReSymp programme of annual sustainable research symposiums It is being organised in collaboration with EMBO the Sustainable European Laboratories Network SELs and with support from the European Union s Climate Pact...

Brendan Rouse, Marta Rodríguez-Martínez, Philipp Weber, Martin Farley, Valeria Scagliotti

23 April 2025

From variant to drug target: using the expanded Open Targets Platform to explore the genetics of target discovery

Description The Open Targets Platform is a comprehensive research tool that supports systematic identification and prioritisation of potential therapeutic drug targets By integrating publicly available datasets along with data generated by the Open Targets consortium the Platform builds and scores target disease associations Earlier this year the Platform was expanded through the inclusion of variant study and credible set information The Platform now includes comprehensive variant annotation and the results of state of the art large scale statistical analysis including fine mapping colocalisation and locus to gene assignment across all complex and molecular traits Drawing from the GWAS Catalog the eQTL Catalogue FinnGen the UK Biobank Pharma Proteomics Project and more users can browse over 2 6 million credible sets to build more robust therapeutic hypotheses This webinar will provide an introduction to the capabilities and use cases for the Open Targets Platform and demonstrate the impact of the newly introduced data These allow you to dig deeper into the GWAS evidence for a target disease association explore our analyses of GWAS and molecular QTL studies and relevant annotation data...

16 April 2025

LLMs in bioinformatics Q&A session

Description Join us for a live panel discussion as part of our ongoing webinar series Large Language Models and their applications in bioinformatics This interactive Q A session offers attendees the opportunity to engage with speakers from the series ask new questions and revisit key discussions You can submit your questions for the panel in advance using this document Questions for the panelThe panel will review and prioritise the questions submitted in this document along with those asked throughout the series before opening the floor to live queries from participants To find more details on the webinars from this series visit the event webpage https www ebi ac uk training events large language models and their applications bioinformatics...

10 April 2025

Exploring Human Disease and Protein Variant Data in UniProtKB and Contextualising Variation with ProtVar

Description UniProt KnowledgeBase UniProtKB supports biomedical research by providing a comprehensive high quality and freely accessible resource of protein sequence and functional information During this webinar we will provide an overview of how to access the human disease and protein variant information available in UniProtKB as well as contextualising protein variation with protein structure and function using ProtVar We will outline the annotation of protein molecular function involvement in human disease as well as disease associated variants including variant position variant characterisation and their impact on protein structure and function The protein variant viewer and feature viewer will be presented and we will show how the feature viewer facilitates visualisation of variant co localisation and impact on protein features and 3D structure Cross links to human specific databases and tools such as BLAST and Align will be briefly discussed We will give an overview of ProtVar a tool that combines data from UniProt PDBe Ensembl and novel predictions for the interpretation of missense variation in humans ProtVar helps users contextualise and interpret human missense variation within proteins to identify the potential effects of variation concerning human health and disease We will briefly introduce programmatic access to the UniProt Proteins API and ProtVar API and give examples on how to download human variation datasets available in UniProtKB Finally we will take live questions from the audience The UniProt APIs are available at https www uniprot org help programmatic accessThe ProtVar API is available at https www ebi ac uk ProtVar api swagger ui index html...

8 April - 11 April 2025

Wild frontiers of model organisms

Description OverviewSpeakersProgrammePractical informationSponsors SupportersAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview The scientific community relies on a small number of model organisms to study larger themes in biology with the assumption that gained insights can be extrapolated to most other organisms However recent advances in our ability to study organisms in the context of their natural environments have revealed that Jacques Monod s famous quote What is true for E coli is true for the elephant does not do justice to the vast diversity of life on our planet We will highlight research that challenges classical model organisms by looking at fluctuating natural environments as a rich relevant inspiration for new experiments in the lab and explore the challenges associated with the establishment of new model systems This conference will showcase how exploring the wild frontiers of model systems is increasing our understanding of the biology ecology and evolution of organisms ranging from microbes to plants and animals We hope to bring together lab and field focused researchers from ecology genomics quantitative cell and molecular biology Our aim is to debate the possibilities and limitations inherent to these disciplines and to develop unified approaches to gain comprehensive mechanistic insights into the natural world Session topics Cell biology Genomics Technology development Development Ecology Species interaction Establishing model systems Evolution Speakers Erik Andersen Johns Hopkins University USA Corentin Bisot Vrije Universiteit Amsterdam The Netherlands Angela Hancock Purdue University USA Yen Ping Hsueh Max Planck Institute for Biology T bingen Germany Abderrahman Khila The cole normale sup rieure de Lyon Centre National de la Recherche Scientifique UMR5242 France Fr d rique Le Roux University of Montreal Canada Nikolaus Tobias Leisch EMBL Heidelberg Germany Margaret McFall Ngai Carnegie Science USA Virtual speaker T m Mignot Institute of Mediterranean Microbiology France Jean Baptiste Raina French National Centre for Scientific Research France University of Technology Sydney Australia Em lia Santos University of Cambridge UK Lauren Saunders Heidelberg University Germany Joseph Schacherer University of Strasbourg CNRS France Hanh Vu EMBL Heidelberg Germany Arielle Woznica The University of Texas at Austin USA Virtual speaker Scientific Organisers Susana Coelho Max Planck Institute for Biology T bingen Germany Gautam Dey EMBL Heidelberg Germany Michael Dorrity EMBL Heidelberg Germany Nicole Dubilier Max Planck Institute for Marine Microbiology Germany Flora Vincent EMBL Heidelberg Germany Conference organiser Nathalie Sneider EMBL Heidelberg Germany Programme Are you on social media Post using EESWildModels and don t forget to tag EMBLEvents Note that the below programme is preliminary and will be updated with further details after the abstract selection All talks are planned to take place on site only For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Please find the poster listing here The bus schedule for this conference is available here Day 1 Tuesday 8 April 2025 Time Europe Berlin Speaker12 30 14 00Registration and light refreshments14 00 14 15Opening remarks14 15 17 15Session 1Chair Susana Coelho Max Planck Institute for Biology T bingen Germany14 15 14 45Unlocking nature s arsenal investigating phage bacteria dynamics in aquatic ecosystems for sustainable aquacultureFr d rique Le Roux University of Montreal Canada14 45 15 00Mapping the sub cellular mechanisms of endosymbiosis in Aiptasia a model for coralsBen Jenkins University of Cambridge UK15 00 15 15The origins of death at sea characterizing conserved cell death and survival genes in distant algaeAvia Mizrachi Weizmann Institute of Science Israel15 15 15 45EMBO Young Investigator LectureCuticular collagens mediate cross kingdom predator prey interactions between nematodes and trapping fungiYen Ping Hsueh Max Planck Institute for Biology T bingen Germany15 45 16 15Coffee Break and Meet the speakers16 15 16 45How to recognize your symbiotic partner with each new generation Lessons from the squid vibrio associationMargaret McFall Ngai Carnegie Science USA Virtual speaker 16 45 17 00Adaptive cellular evolution in the intestinal tracts of hyperdiverse African cichlid fishesPatrick Tschopp University of Basel Switzerland17 00 17 15Natural variation in C elegans aggregation behavior reveals possible adaptation to changing environmentsYoun Jae Kang Max Planck Institute of Animal Behavior Germany17 15 18 15Poster sneak peek18 15 19 45Dinner in Canteen19 45 21 15Pub Quiz and After dinner drinks in Canteen Day 2 Wednesday 9 April 2025 Time Europe Berlin Speaker09 00 11 45Session 2Chair Patrick Tschopp University of Basel Switzerland09 00 09 30Unifying cellular and organismal biodiversity through scalable transcriptomicsLauren Saunders Heidelberg University Germany09 30 09 45Draparnaldia insights into alternative mechanisms of multicellularity and terrestrialization in green lineageLenka Caisova Biology Center of the Czech Academy of Sciences Czech Republic09 45 10 00Immune control of coral endosymbiosis lessons from the model AiptasiaMeghan Ferguson Ludwig Maximilians University of Munich Germany10 00 10 15A handoff from maternal to zygotic sunscreens protects larval zebrafish from UVRKristin Johnson University of Utah USA10 15 10 45Coffee Break and Meet the speakers10 45 11 15Water striders a journey to building an emerging modelAbderrahman Khila The cole normale sup rieure de Lyon Centre National de la Recherche Scientifique UMR5242 France11 15 11 30The dynamics of coexistence and succession on a decaying beetleAta Kalirad Max Planck Institute for Biology T bingen Germany11 30 11 45Risk reward trade off in motility endurance generates dichotomy in search strategies among copiotrophic marine bacteriaJohannes Keegstra ETH Z rich Switzerland11 45 13 30Vegetarian lunch and Meet the editors between 13 00 13 30 in the Foyer with Lavinia Arseni from FEBS LettersSara Monaco from Review CommonsYehu Moran from EMBO Press13 30 16 30Session 3Chair Flora Vincent EMBL Heidelberg Germany13 30 14 00Where the wild things are host microbe interaction of symbiotic marine nematodes and how to tackle themNikolaus Tobias Leisch EMBL Heidelberg Germany14 00 14 15Paradiplonema papillatum creating a new model pays offDrahom ra Faktorov Biology Center of the Czech Academy of Sciences Czech Republic14 15 14 30Exploring the potential of Calcidiscus leptoporus as a new model system for understanding the ecology of coccolithophoresJelena Godrijan Ruder Boskovic Institute Croatia14 30 15 00Coffee Break and Meet the speakers15 00 15 30Wild frontiers in A thaliana finding new model systems within a well studied model speciesAngela Hancock Purdue University USA15 30 15 45Arabidopsis in natura Neighbor GWAS to study defense against herbivory and PlantServation to study environmental robustness of allopolyploidsKentaro Shimizu University of Zurich Switzerland Yokohama City University Japan15 45 16 00Investigating molecular determinants of nociception in Octopus vulgaris through a model hopping approachEleonora Maria Pieroni University of Southampton United Kingdom16 00 16 30Flash talks odd numbers 2 minutes each 1 slide 45 Grazia Battaglino 53 Anne Materne 63 Katerina Romanova 73 Thomas Beavis16 30 18 15Poster Session 1 odd numbers 18 15Free evening Day 3 Thursday 10 April 2025 Time Europe Berlin Speaker09 00 12 15Session 4Chair Gautam Dey EMBL Heidelberg Germany09 00 09 30The natural and likely ancestral niche of Caenorhabditis nematodes Erik Andersen Johns Hopkins University USA09 30 09 45Dominance reversal maintains large effect resistance polymorphism in temporally fluctuating environmentsMarianthi Karageorgi Stanford Universuity USA09 45 10 00The intricate relationship between Drosophila and Caenorhabditis in their natural habitatJulia Johnke Kiel University Germany10 00 10 15Awakening tissue regeneration from the superpowers of regenerative species to enhanced tissue repair of scar prone organismsAntonio Tomasso Stanford University USA10 15 10 45Coffee Break and Meet the speakers10 45 11 15Mechanisms underlying colour pattern variation within and between species of cichlid fishesEm lia Santos University of Cambridge UKNot available on demand11 15 11 30Global temperature stress drives cell type specific loss of functionMantha Lamprousi EMBL Heidelberg Germany11 30 11 45Clonal aggregative multicellularity entrained by salinity in one of the closest relatives of animalsN ria Ros Rocher Institut Pasteur France11 45 12 15Evolution of gene expression variation related to domestication processes in yeast populationsJoseph Schacherer University of Strasbourg CNRS France12 15 13 45Lunch13 45 16 45Session 5Chair Jelena Godrijan Ruder Boskovic Institute Croatia13 45 14 15Identifying phytoplankton bacteria symbiosesJean Baptiste Raina French National Centre for Scientific Research France University of Technology Sydney Australia14 15 14 30Exploring rhizosphere interactions in the wildGuy Keren Weizmann Institute of Science Israel14 30 14 45Sex determination and life cycle controls in the marine diatom Pseudo nitzschia multistriataMaria Immacolata Ferrante Stazione Zoologica Anton Dohrn Italy14 45 15 15Coffee Break and Meet the speakers15 15 15 45Choanoflagellates New Models for Studying Host Pathogen Interactions and ImmunityArielle Woznica The University of Texas at Austin USA Virtual speaker 15 45 16 00Unveiling the dynamics of the interaction between Myxococcus xanthus and soil fungi by a multiscale approachClaudia Petrillo Laboratoire de Chimie Bact rienne LCB Institut de Microbiologie de la M diterran e IMM CNRS Aix Marseille Universit France16 00 16 15Vertical transmission of brown algal virus in the laboratory and in the fieldCarole Duchene Max Planck Institute for Biology T bingen GermanyNot available on demand16 15 16 45Flash talks even numbers 2 minutes each 1 slide 48 Ulisse Cardini 50 Stefan Bertilsson 52 Jaruwatana Sodai Lotharukpong 54 Thomas Mathers 56 Elizaveta Miticheva 62 Jan Robering 66 Jana Seiler 68 Jerzy Witwinowski 70 Gaurav Vaidya 72 Frederic Zimmer16 45 18 15Poster Session 2 even numbers 18 15 20 15Conference dinner in the canteen20 15 23 00Party Day 4 Friday 11 April 2025 Time Europe Berlin Speaker09 00 12 15Session 6Chair Michael Dorrity EMBL Heidelberg Germany09 00 09 30Carbon supply for growth drives bidirectional flows in mycorrhizal networksCorentin Bisot Vrije Universiteit Amsterdam The Netherlands09 30 09 45Tunneling nanotubes the communication wires in amoebaeHarikumar Suma Leibniz Institute for Natural Product Research and Infection Biology Leibniz HKI Germany09 30 09 45Genomes of nitrogen fixing eukaryotes reveal a non canonical model of organellogenesisEllen Yeh Stanford University USA10 00 10 30On body size and life history of planarian flatwormsHanh Vu EMBL Heidelberg Germany10 30 11 00Coffee Break and Meet the speakers11 00 11 15Exposing the mechanisms underlying hidden reproductive phenotypes in C elegansOfer Rog University of Utah USA11 15 11 30Temperature induced developmental scaling and disruption in embryos of the ascidian ciona intestinalisJonas Brandenburg University of Bergen Norway11 30 11 45A comparative analysis of the energetics of early development across animal phylaVinca Yadav Max Planck Institute of Molecular Cell Biology and Genetics Germany11 45 12 15Mechanisms and evolution of bacterial predation from molecular strategies to ecological impactT m Mignot Institute of Mediterranean Microbiology France12 15 12 30Closing Remarks and Poster Prize Announcements12 30 12 50Lunch to go and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 200Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Nathalie Sneider for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Friday 7 March 2025 in some cases at special rates Please email the hotel directly quoting the booking code EES25 02 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergSteffi s Hostel HeidelbergHotel Bayrischer Hof Leonardo Hotel Heidelberg City CentreHotel Vier Jahreszeiten HeidelbergB B HotelHotel MonptiExzellenz HotelPremier Inn Heidelberg CityHilton HeidelbergStaycity Aparthotel Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses The bus schedule for this conference is available here Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Supporters Event supporters Event sponsor Union Biometrica Media partners ChemBioChem a Wiley journal EMBO Reports an EMBO Press journal FEBS Letters a FEBS Press journal FEBS Open Bio a FEBS Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Susana Coelho, Gautam Dey, Michael Dorrity, Nicole Dubilier, Flora Vincent

7 April - 14 April 2025

Microbial metagenomics: a 360º approach

Description OverviewSpeakers trainers and staffProgrammePractical informationSponsorsMedia kit Overview Course overview This course will provide a global overview of the different metagenomic approaches to study microbial communities covering methods for the functional search of genes sequencing of metagenomes using the most recent technologies and in silico methods for sequence analysis During the course participants will receive an overview of state of the art genomic technologies and bioinformatic tools A balanced approach of lectures and practical sessions will provide a general background and the latest advancements in the field as well as its relationship with other disciplines The course will begin with experimental training in functional metagenomics by preparing metagenomic libraries for gene searching Metagenomic DNA will be isolated from soil samples to analyze bacterial diversity in situ by third generation sequencing Nanopore Cutting edge single cell microbial genomics using microfluidics will be addressed Additionally students will learn bioinformatics analysis of metagenomic datasets from raw sequences to the application of algorithms Follow up practical exercises and sessions to discuss experimental design will allow students to learn and test their knowledge In summary this course will allow participants to work through the entire workflow from sample preparation to in silico data analysis Audience This course is aimed at advanced PhD students and post doctoral researchers who are doing or planning to start research in the field of metagenomics Modules resources Experimental design Extraction of metagenomic DNA Construction of metagenomic libraries Single cell microbial genomics 3rd generation sequencing Nanopore Bioinformatic analysis of metagenomic data data standards and submission processing of raw data assembly functional annotation overview of databases retrieval and analysis tools Learning outcomes Construct your own metagenomic library Analyse and organise your data Interpret results explore different databases use different retrieval and analysis tools Sequence analysis What past participants say about the course This course gave me the opportunity to learn from my coursemates and understand the software used in metagenomics The speakers were friendly and are always ready to answer our research questions and provide us with valuable advice and comments Lee Hwei Huih The University of Hong Kong This event has been granted the following EMBO sustainability badge Grade 1 of 3 Speakers trainers and staff Josefa Ant n Botella University of Alicante Spain Eugeni Belda National Institute for Health and Medical Research Inserm France Vladimir Benes EMBL Heidelberg Germany Giuseppe D Auria FISABIO Sequencing and Bioinformatics Spain Anupam Gautam T bingen University Germany Patrick Hasenfeld EMBL Heidelberg Germany Daniel Huson T bingen University Germany Varsha Kale EMBL EBI Hinxton UK Kostas Konstantinidis Georgia Institute of Technology USA Raul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales Spain Mireia Osuna Lopez EMBL Heidelberg Germany Hilal Ozgur EMBL Heidelberg Germany Pierre Padilla Pontificia Universidad Cat lica de Chile Chile Sadaf Pashapour Heidelberg University Germany Gabrielle Potocki Veronese French National Institute for Agricultural Research INRA France Jan Provaznik EMBL Heidelberg Germnay Mariana Reyes Prieto FISABIO Sequencing and Bioinformatics Spain Luis Miguel Rodriguez R University of Innsbruck Austria Jessica Lynn Sutter EMBL Heideilberg Germany Laura Villacorta EMBL Heidelberg Germany Kristian Vlahovicek University of Zagreb Croatia Daphne Welter EMBL Heidelberg Germany Tobias Wenzel Pontificia Universidad Cat lica de Chile Chile Virtual Speaker Scientific organisers Jos Eduardo Gonz lez Pastor Centro de Astrobiolog a CSIC INTA Spain He was a key organiser of this course We honour his legacy friendship and contributions Vladimir Benes EMBL Heidelberg Germany Giuseppe D Auria FISABIO Sequencing and Bioinformatics Spain Arantxa L pez L pez Hospital Can Misses Spain Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Maria Bacadare Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez Scientific Training Manager Swetlana Krez EMBL Heidelberg Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOMetaG and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Monday 24 March 2025 Time Europe Berlin SpeakerLocation16 00 17 00Overview of pre course work introduction to course content on EMBL eCampus and troubleshootingGiuseppe D Auria FISABIO SpainKostas Konstantinidis Georgia Institute of Technology USAElisabeth Zielonka EMBL Heidelberg GermanyVirtual Zoom meeting Day 1 Monday 7 April 2025 Time Europe Berlin SessionLocation09 00 09 30Welcome house notes and safetyCourtyard Room A B09 30 09 45Welcome and IntroductionsElisabeth Zielonka EMBL Heidelberg GermanyCourtyard Room A B09 45 10 45Flash talks participants2 min per participant Courtyard Room A B10 45 11 00BreakCourtyard Room A B11 00 12 00Metagenomics Concepts historical milestones and next advanceGiuseppe D Auria FISABIO SpainCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Metagenomics library preparation for NGSVladimir Benes EMBL Heidelberg GermanyCourtyard Room A B14 00 15 00Group Activity Participants challenges expectations and case studiesElisabeth Zielonka EMBL Heidelberg GermanyCourtyard Room A B15 00 16 00The impact of Metagenomics on genes and genomes discoveryGabrielle Potock i Veronese INRA LISBP FranceCourtyard Room A B16 00 16 30BreakCourtyard Room A B16 30 17 30Metagenomics and other culture independent tools to study virus communitiesJosefa Ant n Botella University of Alicante SpainCourtyard Room A B17 30 20 00Poster Session 1 and pizza dinnerATC Rooftop lounge20 00Bus to ISG HotelCourtyard Room A B Day 2 Tuesday 8 April 2025 Time Europe Berlin SessionLocation09 00 10 45Practical Extraction of metagenomic DNA in groups from soil samplesRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales SpainMireia Osuna Lopez EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B10 45 11 15BreakCourtyard Room A B11 15 12 45Practical Quality control of DNA samples Gel analysis Qubit assay Nanopore 16S PCR set upRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales SpainMireia Osuna Lopez EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyJessica Lynn Sutter EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B12 45 13 45LunchEMBL Canteen13 45 14 30Discussion of metagenomic DNA Extraction ResultsGiuseppe D Auria FISABIO SpainRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales SpainCourtyard Room A B14 30 15 30Practical introduction Single cells genomics in dropletsTobias Wenzel Pontificia Universidad Cat lica de Chile Chile Virtual speaker Courtyard Room A B15 30 16 45Practical Nanopore 16S PCR cleanup finishing library preparation and starting sequencing run followed by Genomics Core Facility TourMireia Osuna Lopez EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B16 45 17 15BreakCourtyard Room A B17 15 19 15Practical Nanopore 16S analysis DNA cleanup and Sequencing start followed by Genomics Core Facility TourMireia Osuna Lopez EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B19 15 19 30Bus to ISG HotelEMBL bus stop20 00Dinner at ISG Hotel Day 3 Wednesday 9 April 2025 Time Europe Berlin SessionLocation09 00 09 45Practical Test digestion conditions for metagenomic DNA and preparation of agarose gelsRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales SpainJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B09 45 10 45What brings a metagenomic approach in cardiometabolic and nutrition related disorders Eugeni Belda National Institute for Health and Medical Research Inserm FranceCourtyard Room A B10 45 11 15BreakCourtyard Room A B11 15 11 45Practical Loading agarose gels of test digestionRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias NaturalesJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B11 45 12 45LunchEMBL Canteen12 45 14 15Practical Analysis of test digestion Scale up of digestion of metagenomic DNA for cloning in the librariesLoad gel of scale up once that digestion conditions are determined Raul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales SpainJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B14 15 14 45Break gel runs meanwhile Courtyard Room A B14 45 16 45Practical Purification from gel of the digested metagenomic DNA Cloning of the metagenomic DNA overnight ligationRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias Naturales SpainJessica Lynn Sutter EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab B16 45 17 45Practical Preparing bacterial cultures for droplet generation and demonstration of the droplet generation set upPatrick Hasenfeld EMBL Heidelberg GermanyPierre Padilla Huamantinco Pontificia Universidad Cat lica de Chile ChileSadaf Pashapour Institute for Molecular Systems Engineering and Advanced Materials IMSEAM Heidelberg GermanyTobias Wenzel Pontificia Universidad Cat lica de Chile ChileTraining Lab B17 45 18 15BreakCourtyard Room A B18 15 19 30Droplet generation in groupsPatrick Hasenfeld EMBL Heidelberg GermanyPierre Padilla Huamantinco Pontificia Universidad Cat lica de Chile ChileSadaf Pashapour Institute for Molecular Systems Engineering and Advanced Materials IMSEAM Heidelberg GermanyTobias Wenzel Pontificia Universidad Cat lica de Chile ChileTraining Lab B19 30 20 30DinnerEMBL Canteen20 30Bus to ISG HotelEMBL bus stop Day 4 Thursday 10 April 2025 Time Europe Berlin SessionLocation09 00 11 00Practical Inactivation of Ligase Dialysis Transformation of E Coli Electroporation Raul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias NaturalesTraining Lab B11 00 12 00Methodological discussion of practical session 1 Metagenomics experimental design Common shortcoming and pitfallsRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias NaturalesFlex Lab A B12 00 13 00LunchEMBL Canteen13 00 15 00Practical Solving problems and questions Introduction to Linux and R based on pre recorded lecture 1 and 2Giuseppe D Auria FISABIO SpainComputer Training Lab15 00 16 00Pratical Comparison of sequencing technologies Nanopore 16S PacBioGiuseppe D Auria FISABIO SpainComputer Training Lab16 00 16 30BreakCourtyard Room A B16 30 17 30Pacific Bioscience PacBio sequencing for metagenomicsVladimir Benes EMBL Heidelberg GermanyCourtyard Room A B17 30 18 00Bus back to ISG hotel and DowntownEMBL bus stop18 00 18 30Free evening Day 5 Friday 11 April 2025 Time Europe Berlin SessionLocation09 00 09 45Practical Analysis of some colonies from the metagenomic libraries Interpretation of resultsRaul Munoz Jimenez Microbial Ecology Museo Nacional de Ciencias NaturalesTraining Lab B09 45 11 45Practical Visualization of Droplets and discussion about microfluidic designsPatrick Hasenfeld EMBL Heidelberg GermanyPierre Padilla Huamantinco Pontificia Universidad Cat lica de Chile ChileSadaf Pashapour Institute for Molecular Systems Engineering and Advanced Materials IMSEAM Heidelberg GermanyTobias Wenzel Pontificia Universidad Cat lica de Chile ChileTraining Lab B11 45 12 45LunchEMBL Canteen12 45 13 45Functional and taxonomic analysis with MGnifyVarsha Kale EMBL EBI Hinxton UKComputer Training Lab13 45 15 45Practical Functional and taxonomic analysis with MGnifyVarsha Kale EMBL EBI Hinxton UKComputer Training Lab15 45 16 15Break16 15 17 00EPI2ME and data analysis of Nanopore 16S soil samplesGiuseppe D Auria FISABIO SpainJan Provaznik EMBL Heidelberg GermanyCourtyard Room A B17 00 18 00Metabolomic profiling of microbial communitiesMariana Reyes Prieto FISABIO SpainComputer Training Lab18 00 20 00Poster session with tapas dinnerATC Rooftop lounge20 00Bus back to the ISG HotelEMBL bus stop Day 6 Saturday 12 April 2025 Time Europe Berlin SessionLocation09 00 12 30Introduction to 16S rDNA profiling Illumina PacBio Practical 6 16S rDNA profiling Illumina PacBio Mariana Reyes Prieto FISABIO SpainFlexible breakComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 14 45Practical Practice to 16S rDNA profiling Illumina PacBio Mariana Reyes Prieto FISABIO SpainComputer Training Lab14 45 15 15BreakCourtyard Room A B15 15 17 00Practical Genome Resolved MetagenomicKostas Konstantinidis Georgia Institute of Technology USALuis Miguel Rodriguez R University of Innsbruck AustriaComputer Training Lab17 00 17 30BreakCourtyard Room A B17 30 19 30Practical Genome Resolved MetagenomicKostas Konstantinidis Georgia Institute of Technology USALuis Miguel Rodriguez R University of Innsbruck AustriaComputer Training Lab19 30 20 30DinnerEMBL Canteen20 30Bus back to the ISG Hotel Day 7 Sunday 13 April 2025 Time Europe Berlin SessionLocation09 00 11 15Practical Metagenomic assembly ORF finding functional annotation Giuseppe D Auria FISABIO SpainComputer Training Lab11 15 11 30BreakCourtyard Room A B11 30 12 30Analysis Tools Overview INCA MILC and MELPKristian Vlahovicek University of Zagreb CroatiaComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 30Practical INCAKristian Vlahovicek University of Zagreb CroatiaComputer Training Lab15 30 16 00BreakCourtyard Room A B16 00 18 00Student presentation preparation time Case StudiesAll trainers and speakersCourtyard Room A B18 00 19 00Bus Downtown19 00 21 30Dinner Downtown21 30Bus back to the ISG Hotel Day 8 Monday 14 April 2025 Time Europe Berlin SessionLocation09 45 11 45Practical Metagenomic analysis using DIAMOND MEGANAnupam Gautam University of T bingen GermanyDaniel Huson University of T bingen GermanyComputer Training Lab11 45 12 45LunchEMBL Canteen12 45 13 45Practical Metagenomic analysis using DIAMOND MEGANAnupam Gautam University of T bingen GermanyDaniel Huson University of T bingen GermanyComputer Training Lab13 45 15 15Group activity and presentations Case StudiesVladimir Benes EMBL Heidelberg GermanyGiuseppe D Auria FISABIO SpainElisabeth Zielonka EMBL Heidelberg GermanyCourtyard Room A B15 15 15 45Wrap up and conclusionsCourtyard Room A B15 45 16 00Bus to Heidelberg train station and DowntownEMBL bus stop Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 550PhD Student 550Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation will be booked for the selected participants at the ISG Hotel for the default dates of Sunday 6 April to Monday 14 April 8 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISG Hotel during your stay We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Virtual participation guidelines DELETE THIS TAB IF COURSE IS NOT HYBRID Guidelines Do not broadcast the course to unregistered participants Do not share your login details with others You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in eCampus for you to enjoy during the event How to ask questions Questions during and after the talks can be asked in the live streaming platform If time runs out or you think of a question later you can use the EMBL eCampus forum or send a direct message to the speaker trainer Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated As many virtual participants are attending from around the world we do our best to accommodate as many time zones as possible when creating the programme Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Event sponsors Event supporters Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Giuseppe D´Auria, José Eduardo González-Pastor, Elisabeth Zielonka

2 April 2025

Domain-specific knowledge extraction from scientific texts using LLMs

Description This webinar will explore how Large Language Models LLMs can streamline the extraction of critical information from scientific texts focusing on patient derived cancer models PDCMs PDCMs are vital tools for cancer research and preclinical studies with a growing body of literature in this field However manually extracting and curating information from scientific texts is labor intensive and prone to delays In this session we will introduce two innovative approaches direct prompting and soft prompting Direct prompting uses manually created instructions to extract PDCM related entities while soft prompting leverages machine learning to train continuous vector prompts We will discuss our comparative evaluation using state of the art proprietary and open source LLMs demonstrating how tailored prompt engineering can elevate the performance of smaller open models to match proprietary counterparts This session will highlight the potential of LLMs to enhance domain specific knowledge extraction and accelerate research workflows...

31 March - 4 April 2025

Microscopy data analysis: machine learning and the BioImage Archive

Description This virtual course will show how public bioimaging data resources centred around the BioImage Archive enable and enhance machine learning based image analysis The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi modal imaging data at the cell and tissue scale Participants will cover contemporary biological image analysis with an emphasis on machine learning methods as well as how to access and use images from databases Virtual courseThis course will be a virtual event delivered via a mixture of live streamed sessions pre recorded lectures and tutorials with live support We will be using Zoom to run the live sessions all fully password protected with automated English closed captioning and transcription with support and both scientific and social networking opportunities provided by Slack and other methods taking different time zones into account In order to make the most out of the course you should make sure to have a stable internet connection throughout the week and are available between 08 00 18 00 BST each day In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Selected participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course...

Anca Belu

31 March - 2 April 2025

AI in one health

Description OverviewScientific OrganisersSpeakersYoung Investigators MeetingProgrammePractical InformationSponsorsMedia kit Overview Overview The 5th EMBL Partnership Conference will be held in Heidelberg from 31 March 02 April 2025 The conference brings together EMBL and its partner institutes to enable the exchange of expertise and build new collaborations and research networks The programme will focus on the impact of the recent advances in artificial intelligence AI on topics related to Health and related life science areas across 3 different sessions Session topics Molecular medicine and precision health Genetics and genomics Technology and imaging The Partnership Conference takes place at EMBL every 3 years and allows us to incite interactions with and across the EMBL Partnership network It is organized by EMBL s International Relations in close collaboration with scientific experts from EMBL and the partner institutes Every edition has its distinct focus however the key objective is to pool the complementary expertise of all partners around a topic of common interest and interrogate it in a way that ultimately leads to new ideas and joint scientific projects Plamena Markova EMBL Chief of International Relations Scientific Organisers Oliver Billker The Laboratory for Molecular Infection Medicine Sweden MIMS Sweden Lionel Christiaen Michael Sars Centre Norway Anna Kreshuk EMBL Heidelberg Germany Giancarlo Russo EMBL Partnership Institute for Genome Editing Life Sciences Center Lithuania Sameer Velankar EMBL EBI United Kingdom Qi Zhang SAiGENCI and EMBL Australia Australia Conference Organisers Inna B sselmann EMBL Heidelberg Germany Agata Pernus Voigt EMBL Heidelberg Germany Speakers Keynote speaker Giorgio Metta Italian Institute of Technology Italy Speakers Tatiana Belova Centre for Molecular Medicine Norway Norway Laura Carroll The Laboratory for Molecular Infection Medicine Sweden Sweden Eduardo Eyras EMBL Australia Partnership Laboratory Australia Anna Ferraioli Sars International Centre for Marine Molecular Biology Norway Tomas Fitzgerald EMBL EBI UK Andrea Ganna Institute for Molecular Medicine Finland Finland Tibor Pankotai Hungarian Centre of Excellence for Molecular Medicine Hungary Jonas Kubilius Vilnius University Life Sciences Center Lithuania Andreas Kulozik EMBL Heidelberg Germany Vikt ria L z r Hungarian Centre of Excellence for Molecular Medicine Hungary Miguel Leung Hubrecht Institute Netherlands Mo Lotfollahi Welcome Genome Campus Hinxton UK Danny Sahtoe Hubrecht Institute Netherlands Patrick Steinmetz University of Bergen Norway Nina Linder FIMM Institute for Molecular Medicine Finland Finland Magdalena Szponar Nencki Institute of Experimental Biology Poland Daisy Kavanagh Garvan Institute of Medical Research Australia Maria Zimmermann Kogadeeva EMBL Heidelberg Germany Young Investigators Meeting The Young Investigators Meeting YIM is a 1 day event that takes place on 31 March 2025 at EMBL Heidelberg The meeting will bring together PhD students and postdoctoral fellows from EMBL and its partner institutes It provides an excellent opportunity to meet peers from different institutes discuss scientific discoveries exchange ideas and experiences get inspired and most importantly to have fun Organisers EMBL Germany Julia Costea Purna Sham Gadre MIMS Sweden Rachel Feeney Supapit Wongkuna Hubrecht Institute The Netherlands Xuan Zheng Carlota Davo Martinez HCEMM Hungary Zsuzsanna Rethi Nagy VU LSC Lithuania R ta Matulevi i t Programme Are you on social media Post using EMBLAIOneHealth and don t forget to tag EMBLEvents This conference will not be recorded The bus schedule for the shuttle bus is available here Young Investigators Meeting Monday 31 March 2025 Time Europe Berlin SessionLocation08 00 09 00Arrival and registrationOperon Foyer09 00 10 00Networking Group activities to meet fellow YIM participantsTrainers R ta Matulevi i t Carlota Davo Zsuzsanna Rethi NagyLarge Operon10 00 12 00Workshop Promoting Your Personal ImpactTrainer Dr CJ Fitzsimons Leadership Sculptor GermanyAs an early stage researcher getting caught up in your science and planning your experiments is easy Promoting your personal impact gets short shrift until it s too late In this interactive workshop you learn how to use two tools to enhance this impact At the strategic level you learn how to make the most of your current position or how to prepare yourself for your next career step At the tactical level you learn how to tailor talking about your work to any target audience Large Operon12 00 13 00LunchOperon Foyer13 00 14 15Career panel Moderators Rachel Feeney Purna Sham Gadre Julia CosteaSpeakers Ieva Gailite The EMBO journal GermanySara Kathrin Goetz PROTEROS GermanyBirgit Kerber EMBLEM GermanySourabh Bhide GSK GermanyJonas Kubilius Vilnius University Life Sciences Center GermanyLarge Operon14 15 14 30Short breakOperon Foyer14 30 15 30Career panel discussionModerators Rachel Feeney Purna Sham Gadre Julia CosteaTwo 30 minute sessions where participants select two speakers to talk to and switch groups after the first session Large Operon15 30 16 00Career planning resources from the EMBL Fellows Career Service Rachel Coulthard Graf EMBL Heidelberg GermanyLarge Operon Day 1 Monday 31 March 2025 Time Europe Berlin SessionLocation12 30 14 00Registration and light refreshmentsATC Foyer14 00 17 00Workshop for Group Leaders and Senior researchersTrainers Thomas Frick Tobias Maier and Annika L bbert hfp consulting GermanyAbout the workshop To create meaningful connections and establish a robust network among the conference participants the 3 hour workshop by hfp consulting is designed in a highly engaging and dynamic manner to maximize interaction and networking During this time the trainers will facilitate activities designed to warm up the group fostering a lively and vibrant atmosphere These activities will encourage interaction help build a sense of community and set the stage for the rest of the conference The audience will be invited to actively participate in dialogues and dynamic self introductions fostering a spirit of connection The workshop will leave participants energized connected and ready for a productive and engaging conference experience Flex Lab A B17 00 17 30Coffee breakATC Foyer17 30 17 40House notes Agata Pernus Voigt EMBL Heidelberg GermanyATC Auditorium17 40 18 10Flash talk session 1 3 min 1 slide Chair Qi Zhang SAiGENCI EMBL Australia Australia 29 Samuele Cancellieri 33 Bal zs Enyedi 37 Jiahao Guo 39 Yingjia Chen 41 Jiayin Hong 49 Yrj Koski 53 Amanda Lappalainen 79 Linda Sandblad 91 Kinga V r sATC Auditorium18 10 19 30Poster session 1 odd numbers Helix A19 40Bus shuttle to hotels Day 2 Tuesday 1 April 2025 Time Europe Berlin SessionLocation09 30 10 00Arrival and coffee ATC Foyer10 00 10 30Opening remarks by Jan Korbel EMBL Heidelberg GermanyATC Auditorium10 30 11 30Keynote talk Artificial Intelligence for RNA Interactions Disease Prediction and Therapeutic DesignGiorgio Metta Italian Institute of Technology IIT ItalyATC Auditorium11 30 12 00Could artificial intelligence provide global and equitable access to cancer diagnostics Nina Linder University of Helsinki FIMM FinlandATC Auditorium12 00 13 30Group photo lunch and networkingATC FoyerSession 1 Molecular medicine and precision healthChair Giancarlo Russo VU LSC LithuaniaATC Auditorium13 30 14 00Advances in Personalized Treatment and Diagnostics AI Applications in Melanoma and Breast CancerTibor Pankotai HCEMM HungaryATC Auditorium14 00 14 15Multiomic and single cell RNA analyses reveal treatment resistant stem like cells to drive relapse of pediatric T lymphoblastic leukemia T ALL Andreas Kulozik MMPU GermanyATC Auditorium14 15 14 30Machine learning approaches for novel microbial secondary metabolite discoveryLaura Carroll Ume University MIMS SwedenATC Auditorium14 30 15 00Coffee break ATC Foyer15 00 15 30Disease prediction using nation wide health data and geneticsAndrea Ganna University of Helsinki FIMM FinlandATC Auditorium15 30 15 45DELPHI a multi disease state continuous time generative transformer for healthcare trajectory modellingTomas Fitzgerald EMBL EBI United KingdomATC Auditorium15 45 16 00Exploring cancer heterogeneity through gene regulatory networksTatiana Belova University of Oslo NCMM NorwayATC Auditorium16 00 16 30Flash talk session 2 3 min 1 slide Chair Qi Zhang SAiGENCI EMBL Australia Australia 22 Sakina Amin 24 Gantugs Atarsaikhan 40 Francisca Hinrichsen 42 Eirik H ye 48 Ida Kj rsgaard Grene 50 Romika Kumari 60 Matthias Meyer Bender 76 Yulia Rodina 78 Silvano Salaris 88 Iryna YakovenkoATC Auditorium16 30 18 00Poster session 2 even numbers Helix A18 00 20 00Conference dinner EMBL Canteen20 00 23 30Conference party with DJATC Foyer Day 3 Wednesday 2 April 2025 Time Europe Berlin SessionLocation08 30 09 00Arrival and coffee ATC FoyerSession 2 Genetics and genomicsChair Lionel Christiaen Michael Sars Centre NorwayATC Auditorium09 00 09 30Taller or smaller how feeding controls body plasticity in a sea anemonePatrick Steinmetz University of Bergen NorwayATC Auditorium09 30 09 45Advancing antibiotic interaction prediction using AI and analyticsVikt ria L z r HCEMM HungaryATC Auditorium09 45 10 00Systematic engineering of guide RNA repeats to optimize Cas12a editing efficiencyJonas Kubilius Vilnius University VU LSC LithuaniaATC Auditorium10 00 10 30Coffee breakATC Foyer10 30 11 00Discovering gene functions in bacteria with multi omics approaches Maria Zimermann Kogadeeva EMBL Heidelberg GermanyATC Auditorium11 00 11 15Uncovering X chromosome inactivation escape signatures with single cell network analysisDaisy Kavanagh Garvan Institute of Medical Research AustraliaATC Auditorium11 15 11 30Do ctenophores have a brain Connectome and cell type diversity of the aboral organ of the ctenophore Mnemiopsis leidyiAnna Ferraioli Michael Sars Centre University of Bergen NorwayATC Auditorium11 30 13 00Lunch and networkingATC FoyerSession 3 Technology and imagingChair Anna Kreshuk EMBL Heidelberg GermanyATC Auditorium13 00 13 30Generative machine learning to model cellular perturbations Mo Lotfollahi Welcome Genome Campus Hinxton United KingdomATC Auditorium13 30 13 45Machine learning based diagnostic tool for neuropsychiatric disorders using resting state EEGMagdalena Szponar Nencki Institute of Experimental Biology PolandATC Auditorium13 45 14 00Addressing disordered protein regions through computational designDanny Sahtoe Hubrecht Institute The NetherlandsATC Auditorium14 00 14 30Coffee breakATC Foyer14 30 15 00Decoding the epitranscriptome at single molecule resolution Eduardo Eyras Australian National University AustraliaATC Auditorium15 00 15 15Building structural atlases of giant molecular machinesMiguel Leung Hubrecht Institute The NetherlandsATC Auditorium15 15 15 30EMBL Imaging Centre IntroductionTimo Zimmermann EMBL HeidelbergATC Auditorium15 30 15 45Closing remarks and poster prizeATC Auditorium16 15Shuttle bus to hotels and main stationEMBL bus stop Practical Information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses On site Academia 735On site PhD Student 635On site Industry 935 Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee On site participants Types of payments accepted are international bank transfers and credit card payments Abstract submissionOnly registered participants are eligible to submit an abstract After you have logged in and successfully registered you will receive an email asking you to submit your abstract Click on the link provided and enter your abstract in the text box provided Alternatively you can submit your abstract by clicking on the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest of the title should be in lowercase Authors and Affiliations Please fill in the author s details as requested in the online form The compulsory details are First Name Last Name Organisation Name Affiliation or Company Country and Email Mark only one author as the role of First author and please don t forget to indicate who will be presenting The order of the authors will be listed as follows First Author Co First Author alphabetically if multiple co author s in the order added by the submitter Presentation Types When submitting your abstract you can apply for a flash talk or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline Please check our FAQs pages for further information on how to submit an abstract Accommodation and Shuttles The hotels below have rooms on hold for participants until 27 February 2025 in some cases at special rates Please quote the booking code TME25 01 and confirm the exact price of the room with the hotel directly Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreHilton HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier JahreszeitenHotel Holl nder HofHotel Monpti Conference Shuttle Buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Star Inn Hotel close to B B Hotel and Main Train Station Kurf rsten Anlage close to Main Train Station Leonardo Hotel City Centre Bergheimer Strasse Neckarm nzplatz Peterskirche Crowne Plaza ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page Onsite information Catering Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise EMBL Merchandise is available on Mon Thu 9 am 12 pm If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help print your boarding passes train tickets Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on this website www heidelberg marketing com Travel to and from the venue During the event we provide conference shuttle busses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle busses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions EnglishGermanHelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Sponsors Media partners Cancer Drug Resistance an OAE Publishing Inc journal ChemBioChem a Wiley journal Digital Discovery a Royal Society of Chemistry journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Molecular Systems Biology an EMBO Press journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900...

Oliver Billker, Lionel Christiaen, Anna Kreshuk, Giancarlo Russo, Sameer Velankar, Qi Zhang

26 March 2025

BioChatter and the future of LLM driven bioscience

Description LLMs are the biggest new industry on our planet Considering the amount of research and investments in the field large and rapid progress is expected for the coming decade However to make use of the technology we need to have a solid grasp on its technical as well as infrastructural aspects LLM deployment entails a layered tech stack the LLM itself deployment use of services or self hosting technical guardrails instruction fine tuning auxiliary technologies retrieval augmented generation knowledge integration and end user accessibility programming APIs user interfaces Applying the latest knowledge about LLMs in a robust and trustworthy way is an operative challenge despite the large improvements we already see in the wider field In this webinar we will talk about the LLM stack with a focus on open source frameworks that facilitate deployment at various levels The base layer are the deployment frameworks themselves e g Ollama as well as harmonising APIs for open source LLMs by commercial providers The second layer are frameworks for LLM integration into user systems as championed by LangChain The third layer are domain specific frameworks such as our own development BioChatter which also reaches over into the fourth layer dedicated user interfaces To future proof our approach to this powerful technology it is imperative to avoid redundancies in order to not reinvent the wheel we need to be aware of which problems are solved and which are worth tackling We will discuss a flexible framework for using open source technologies at various stages of project maturity from proof of concept to service provision Finally we will discuss the scope of LLM application what can they safely be used for and which applications are still out of reach...

23 March - 28 March 2025

Measuring translational dynamics by ribosome profiling

Description OverviewSpeakers trainers and staffProgrammePractical informationMedia kitSponsors Overview Course overview Regulation of translation is key in the control of gene expression playing a critical role in many biological and pathophysiological settings In the last decade methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes however the systems wide analysis of translation remained an unsolved experimental challenge The advent of ribosome profiling provided the methodological basis for comprehensive transcriptome wide analyses of translation at sub codon resolution by the precise and high throughput determination of ribosomal positions on mRNA Its application in a variety of organisms yielded novel insights into protein synthesis and its dynamic regulation significantly advancing our understanding of the post transcriptional regulation of gene expression Audience The course is aimed at PhD students and early post doctoral researchers who are entering the field of posttranscriptional regulation of gene expression Learning outcomes The practical course Measuring translational dynamics by ribosome profiling aims to a generate a detailed theoretical understanding of ribosome profiling its variations to address specific aspects of translation and its experimental strengths and limitations b provide hands on wet lab training to perform ribosome profiling experiments with the aim to understand and master the critical steps of the experimental workflow and to train the participants to independently perform and adapt similar experiments in their own laboratories c provide hands on bioinformatics training on processing the high throughput sequencing data the quality control and on the use of specialised tools for data generated by ribosome profiling What past participants say about the course The course gave a comprehensive understanding of ribosomal profiling from the theory and the scope of its impact to practical work and analysing the data It was a fantastic week filled with exciting discussions Eleanor Bellows University of Nottingham UK I leave the course much more confident of being able to perform my own Riboseq experiments in near future Ashish Goyal DKFZ Heidelberg Germany This event has been granted the following EMBO sustainability badge Grade 3 of 3 Speakers trainers and staff Pavel Baranov University College Cork Ireland Allen Buskirk Johns Hopkins University School of Medicine United States of America Gionmattia Carancini University College Cork Ireland Cristian Eggers University of Bern Switzerland Nicholas Ingolia University of California Berkeley United States of America Anmol Kiran University College Cork Ireland Liana Lareau University of California Berkeley United States of America Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork Ireland Jan Medenbach University of Regensburg Germany Jan M ller University of Bern Switzerland Johanna Schott University Clinic Mannheim Germany Ayala Shiber Technion Israel Noam Stern Ginossar Weizmann Institute of Science Israel Michal Swirski University of Warsaw Poland Jack Tierney EMBL EBI UK Michael VanInsberghe Hubrecht Institute The Netherlands Elisabeth Zielonka EMBL Heidelberg Germany Scientific organisers Pavel Baranov University College Cork Ireland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Sophie Dutzi Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Senior Scientific Training and Digital Learning Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBORiboProf and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Wednesday 5 March 2025 Onboarding Time Europe Berlin ProgrammeLocation14 00 14 15Welcome by OrganizersVirtual14 15 15 00Course overview and introduction to pre course materialVirtual15 00 15 30Software testing and Q AVirtual Day 1 Sunday 23 March Time Europe Berlin ProgrammeLocation13 30 13 45Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel14 00 14 30Welcome and house notesCourtyard Room A B14 30 15 00Ice Breaking group activityCourtyard Room A B15 00 15 30Coffee BreakCourtyard Room A B15 30 16 00Introduction Overview of the course technology background Pavel Baranov University College Cork IrelandSebastian Leidel University of Bern SwitzerlandJan Medenbach University of Regensburg GermanyCourtyard Room A B16 00 17 00Keynote lecture 1 Ribosome profiling New insights to old questionsNicholas Ingolia University of California Berkeley USAvirtual talkCourtyard Room A B17 00 18 00Keynote lecture 2 How codon specific translation defects trigger cellular quality controlSebastian Leidel University of Bern SwitzerlandCourtyard Room A B18 00 19 30Flash talks by participants speakers and trainerCourtyard Room A B19 30 Departure to HotelATC Entrance19 45Dinner at ISG HotelISG Hotel Day 2 Monday 24 March Time Europe Berlin ProgrammeLocation08 15 08 30Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel08 30 08 45Overview of the day and Laboratory Safety InstructionsCourtyard Room A B08 45 10 00Overview of the protocol introduction to practical workCourtyard Room A B10 00 10 30Coffee BreakCourtyard Room A B10 30 11 30Wetlab Practical 1a Practical work Preparation of RPFs Native extract preparation Trainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B11 30 12 30Wetlab Practical 1bPractical work preparation of RPFsExtract quantification ribonuclease digestion preparation of gradientsTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B12 30 13 00Wetlab Practical 1cPractical work preparation of RPFsStart of ultracentrifugationTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B13 00 14 00LunchEMBL Canteen14 00 16 30Bioinfirmatics Practical 1Computer Class Raw Data processing assessment of sequence data quality adaptors removal removal of rRNA and tRNA reads PCRduplicates removal using UMIs read mapping to genomesand transcriptomes Trainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney EMBL EBI UKComputer Training Lab16 30 17 00Coffee BreakCourtyard Room A B17 00 19 00Wetlab Practical 1DPractical work preparation of RPFsGradient fractionation and RNA preparationTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B19 00 21 00Poster Session 1 DinnerHelix A21 00Departure to HotelATC Entrance Day 3 Tuesday 25 March Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayCourtyard Room A B09 15 11 00Wetlab Practical 1E Practical work preparation of RPFs Size selection of RPFs by PAGE Trainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B11 00 11 30Coffee BreakCourtyard Room A B11 30 12 30Keynote Lecture 3 Understanding Viral biology by ribosome profilingNoam Stern Ginossar Weizmann Institute of Science IsraelCourtyard Room A B12 30 13 00Wetlab Practical 1F Practical work preparation of RPFsGel extraction setup overnight incubation Trainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B13 00 14 00LunchEMBL Canteen14 00 15 00Keynote Lecture 4 Adapting ribosome profiling for bacteriaAllen Buskirk Johns Hopkins University School of Medicine Baltimore USACourtyard Room A B15 00 16 00Bioinformatics Practical 2Computer Class Quality Assessments Analysis of read mapping across different functional regions read length distributionand triplet periodicity metagen profiles for the assessment of global translation Trainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney EMBL EBI UKComputer Training Lab16 00 16 30Coffee Break and course group pictureCourtyard Room A B16 30 17 30Bioinformatics Practical 2 continuedComputer Class Quality Assessments Analysis of read mapping across different functional regions read length distribution and triplet periodicity metagen profiles for the assessment of global translation Trainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney EMBL EBI UKComputer Training Lab17 30 18 30Keynote Lecture 5 New insights through single cell ribosome profilingMichael VanInsberghe Hubrecht Institute KNAW The NetherlandsCourtyard Room A B18 30 18 45Coffee BreakCourtyard Room A B18 45 19 45Group Activity Responsible conduct of research sessionInteractive discussion round Sources of experimental artifacts The technology in different species What are key quality controls Parameter space for optimizationCourtyard Room A B19 45 21 45Poster Session 2 DinnerHelix A21 45Departure to HotelATC Entrance Day 4 Wednesday 26 March Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayCourtyard Room A B09 15 09 45Wetlab Practical 2APractical work Library PreparationDephosphorylationTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B09 45 12 15Bioinformatics Practical 3Computer ClassGoal oriented data analysis Differential gene expression detection of translated ORFs Trainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney EMBL EBI UKComputer Training Lab12 15 13 15Lunch BreakEMBL Canteen13 15 14 15Wetlab Practical 2A continuedPractical work Library PreparationDephosphorylationTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B14 15 15 15Bioinformatics Practical 3 continuedComputer ClassGoal oriented data analysis Differential gene expression detection of translated ORFs translational pauses codon specific decoding rates Ribosome Decision Graphs Trainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney EMBL EBI UKComputer Training Lab15 15 15 45Coffee breakCourtyard Room A B15 45 17 15Bioinformatics Practical 4Computer Class The use of public data resources riboSeq Org andbeyondTrainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney EMBL EBI UKComputer Training Lab17 15 18 00Bus to downtown via ISG HotelATC Entrance18 00 19 30Guided tour of Heidelberg19 30 21 30Course Dinner Day 5 Thursday 27 March Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayCourtyard Room A B09 15 11 15Wetlab Practical 2BPractical work Library preparationSubtractive hybridization 1st purification solid phaseextraction reverse transcriptionTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B11 15 11 30Coffee BreakCourtyard Room A B11 30 13 00Wetlab Practical 2CPractical Work Library preparation2nd purification solid phase extraction circularization of RT productTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B13 00 14 00Lunch BreakEMBL Canteen14 00 15 00Keynote lecture 6 How protein machines are assembled during translation utilizing Selective Ribosome Profiling to capture in vivo co translational interactionsAyala Shiber Technion IsraelCourtyard Room A B15 00 16 00Wetlab Practical 2DPractical Work Library preparation3rd purification solid phase extraction pre amplification PCRTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B16 00 16 30Coffee breakCourtyard Room A B16 30 17 30Keynote Lecture 7 Measuring nascent translationJohanna Schott University Clinic Mannheim GermanyCourtyard Room A B17 30 18 00Wetlab Practical 2EPractical Work Library preparationPurification of PCR productTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B18 00 19 00Bioinformatics Practical 5Computer Class Datamining competition Identifying evidence ofnon standard translation mechanismsTrainers Pavel Baranov University College Cork IrelandGionmattia Carancini University College Cork IrelandAnmol Kiran University College Cork IrelandMichal Swirski University of Warsaw PolandJack Tierney University College Cork IrelandComputer Training Lab19 00 20 00DinnerEMBL Canteen20 00Departure to HotelATC Entrance Day 6 Friday 28 March Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayCourtyard Room A B09 15 10 00Wetlab Practical 2FPractical Work Library preparationScouting PCR preparation of gelsTrainers Christian Eggers University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Gary Loughran University College Cork IrelandJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B10 00 10 30Coffee BreakCourtyard Room A B10 30 12 00Student PresentationsComputer Training Lab12 00 13 00Lunch BreakEMBL Canteen13 00 14 30Student PresentationsComputer Training Lab14 30 15 15Wetlab Practical 2GPractical Work Library preparationAnalysis of PCR products by PAGETrainers Christian Eggers University of Bern SwitzerlandSebastian Leidel University of Bern SwitzerlandGary Loughran University College CorkJan Medenbach University of Regensburg GermanyJan M ller University of Bern SwitzerlandElisabeth Zielonka EMBL Heidelberg GermanyTraining Lab B15 15 16 30Group Activity Responsible Conduct of research sessionDiscussion round Data analysis bottlenecks and artifacts Data management FAIR principles User defined question Future applicationsCourtyard Room A B16 30 17 00Coffee Break17 00 18 00Keynote lecture 8 Deep learning and deep sequencing ribosome profiling for mRNA designLiana Lareau University of California Berkeley USAvirtual talkCourtyard Room A B18 00 18 45Open discussion and feedbackCourtyard Room A B18 45 Departure to HotelATC Entrance19 00 20 30DinnerISG Hotel Practical information Registration fees and motivation letter The course is limited to 18 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 550PhD Student 550Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waivers The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accomodation has been booked for you at the ISG Hotel for the default dates of Sunday 23 March 2025 to Saturday 29 March 2025 6 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISD during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software delete if no technical requirements for this course Technical requirements Will pe communicated ahead of the course Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Sponsors Course partners Course sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de...

Pasha Baranov, Jan Medenbach, Sebastian Leidel, Elisabeth Zielonka

19 March 2025

LLM generated summaries for protein classification at InterPro

Description This webinar will explore how Large Language Models can accelerate protein classification by automatically generating descriptive annotations for previously unannotated protein families Traditionally the process of curating protein family descriptions relies on manual literature review and expert knowledge a time consuming approach that often delays integration into biological databases In this session we will discuss our innovative workflow that leverages LLMs to synthesise functional summaries from existing curated data thereby streamlining the annotation process We will also highlight a comparative evaluation of using both a state of the art GTP model and a fine tuned local model demonstrating that smaller cost effective LLMs can produce high quality descriptions that support rapid protein classification...

18 March - 21 March 2025

Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitAbout Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Resilience to antimicrobial drugs is a rapidly increasing problem of global health Similarly cancer cells that become drug resistant or tolerant affect therapy outcomes for instance during cancer chemotherapy The underlying biological mechanisms of tolerance resistance and persistence are increasingly being studied and reveal a complex interplay between cellular evolution biochemistry and metabolism Understanding these mechanisms holds the long term promise of developing new therapeutic strategies less prone to drug resistance and in the short term enhances our understanding of clonal evolution and single cell biology With this new symposium we aim to gather a highly international group of researchers to exchange in person on the latest work on the biological mechanisms that mediate drug resistance and tolerance across the species barriers Session topics 1 Molecular targets and mechanisms of tolerance and resistance 2 Resistance and tolerance mechanisms of microbiomes and commensals 3 Resistance and tolerance mechanisms single cell biology persistence clonal evolution 4 Resistance and tolerance mechanisms the role of efflux and drug transport 5 Molecular genetics of resistance and tolerance mechanisms 6 The role of macro and microenvironment on resistance tolerance mechanisms Speakers Nathalie Balaban The Hebrew University of Jerusalem Israel Lucas Boeck University of Basel Switzerland David Croucher Garvan Institute of Medical Research Australia Yunn Hwen Gan National University of Singapore Singapore Mariana Gomes de Pinho Instituto de Tecnologia Qu mica e Biol gica Portugal Susanne H u ler Helmholtz Zentrum f r Infektionsforschung GmbH Germany Sophie Helaine Harvard Medical School USA Crispin Hiley UCL Cancer Institute UK Bavesh Kana University of Witwatersrand South Africa Vinay Nandicoori CSIR Centre for Cellular and Molecular Biology India Csaba P l Biological Research Centre Szeged Hungary Nassos Typas EMBL Heidelberg Germany Jane Usher University of Exeter UK Laurence Van Melderen Universit Libre de Bruxelles Belgium Linqi Wang Chinese Academy of Sciences China Rachel Wheatley University of Oxford UK Marvin Whiteley Georgia Institute of Technology USA Itai Yanai NYU Grossman School of Medicine USA Scientific organisers Judith Berman Tel Aviv University Israel Luiz Pedro Sorio de Carvalho The Herbert Wertheim UF Scripps Institute for Biomedical Innovation Technology USA Markus Ralser Institute of Biochemistry Charit Universit tsmedizin Berlin Germany Marina Rodnina Max Planck Institute for Multidisciplinary Sciences Germany Conference organisers Karoline Wolkersdorfer EMBL Heidelberg Germany Programme Are you on social media Post using EESDrugresistance and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise The program isn t structured by session topics This way hopefully all session have something relevant to each participant The bus schedule for the shuttle bus is available here Day 1 Tuesday 18 March 2025 Time Europe Berlin Description12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 15 30Tuesday afternoon sessionChair Judith Berman Tel Aviv University Israel13 45 14 15Functional genomics of Pseudomonas aeruginosaSusanne H u ler Helmholtz Zentrum f r Infektionsforschung Germany14 15 14 30Cross pathway control activation by the absence of Mod5 dependent tRNA isopentenylation confers 5 fluorocytosine resistance in Aspergillus fumigatusAlexander Bruch Leibniz Institute for Natural Product Research and Infection Biology Hans Kn ll Institute Germany14 30 14 45Effect of horizontal transfer and mutation on efflux pump gene regulatory networksSuvam Roy Ume University Sweden14 45 15 15Cellular adaptation to drugs in cancer and bacteriaItai Yanai NYU Grossman School of Medicine USA15 15 15 30Nutrient transport shapes antibiotic efficacy in structured bacterial populationsAnna Hancock Princeton University USA15 30 16 00Coffee Break Meet the speakers16 00 18 00Tuesday afternoon session continued Chair Jane Usher University of Exeter UK16 00 16 30Internal conflicts in Salmonella persisters during infectionSophie Helaine Harvard Medical School USAnot available on demand16 30 16 45Pilin antigenic variation impacts gonococcal lifestyle and antibiotic tolerance by modulating interbacterial forcesBerenike Maier University of Cologne Germany16 45 17 05Mechanisms of drug resistance and tolerance in fungal pathogensJudith Berman Tel Aviv University Israel17 05 17 20Antibiotic tolerance mutations can potentiate lactam resistance in Staphylococcus epidermidisCarolin Kobras University of Oxford UK17 20 18 00Flash TalksFaiza Asghar 50Camille B dard 55Miguel Teixeira 60Marton Czikkely 61Henrich Ga parovic 66Fr d ric Goormaghtigh 70Rotem Gross 71J ssica Guedes 72Chinmaya Jena 76Yogita Kapoor 77Benedikt Kennepohl 78Francesca Macaluso 86Austin Mottola 88Nuno Mira 96Libor Krasny 107Diana Tamayo 108Jarmila Hnilicov 11118 00 19 30Dinner in Canteen19 30 21 00Pub Quiz in Canteen Day 2 Wednesday 19 March 2025 Time Europe Berlin Description09 00 10 00Wednesday morning sessionChair Itai Yanai NYU Grossman School of Medicine USA09 00 09 30Strategies to control delay or revert antimicrobial resistanceNassos Typas EMBL Heidelberg Germany09 30 09 45Exploring the principles behind antibiotics with limited resistanceElvin Maharramov HUN REN Biological Research Centre Hungary09 45 10 00Failed collaborations between immunity and antibiotic treatment enable the evolution of antibiotic tolerance in Streptococcus pneumoniaeJason Rosch St Jude Children s Research Hospital USA10 00 10 45Coffee Break Meet the speakers10 45 11 50Wednesday morning session continued Chair Nathalie Balaban The Hebrew University of Jerusalem Israel10 45 11 15Host induced fungicidal phenotypic resistanceLinqi Wang Chinese Academy of Sciences China11 15 11 30Unravelling the molecular mechanisms behind Prs mediated antibiotic tolerance and its consequences in vivoJo Hobbs University of St Andrews UK11 30 11 50Selective silencing of antibiotic tethered ribosomes as a resistance mechanism against aminoglycosidesIngo Wohlgemuth Max Planck Institute for Multidisciplinary Sciences Germanynot available on demand11 50 13 20Lunch Meet the editors13 20 14 50Wednesday afternoon sessionChair Laurence Van Melderen Universit Libre de Bruxelles Belgium13 20 13 50Defining the mechanisms of antibiotic tolerance in chronic human Pseudomonas aeruginosa infectionsMarvin Whiteley Georgia Institute of Technology USA13 50 14 05Stress driven emergence of heritable non genetic drug resistanceLucy Xie Stanford University USA14 05 14 35Within patient evolution of AMR in Pseudomonas aeruginosaRachel Wheatley University of Oxford UK14 35 14 50Dynamics of cancer stem cell enrichment and consequent loss of treatment response in tumorsDominik Wodarz University of California San Diego USA14 50 15 20Coffee Break Meet the speakers15 20 16 40Wednesday afternoon session continued Chair Marvin Whiteley Georgia Institute of Technology USA15 20 15 50Detection of differentially culturable tubercle bacteria Implications for treatment efficacy and transmissionBavesh Kana University of Witwatersrand South Africa15 50 16 05Understanding bacterial persistence through type I toxin antitoxin system modelingSofija Markovic Faculty of Biology University of Belgrade Serbia16 05 16 25Single cell interactions and metabolic influence on drug toleranceMarkus Ralser Institute of Biochemistry at Charit Universit tsmedizin Berlin Germany16 25 16 40Mechanisms and evolution of resistance to antimicrobial biocidesFrank Schreiber Federal Institute for Materials Research and Testing BAM Germany16 40 18 20Poster Session 1 odd numbers 18 20 19 30Dinner in EMBL Canteen19 30 21 00After dinner drinks in ATC Rooftop lounge Day 3 Thursday 20 March 2025 Time Europe Berlin Description09 00 10 30Thursday morning sessionChair Luiz Pedro Sorio de Carvalho The Herbert Wertheim UF Scripps Institute for Biomedical Innovation Technology USA09 00 09 30Memory of stochastic single cell apoptotic signalling promotes chemoresistanceDavid Croucher Garvan Institute of Medical Research Australia09 30 09 45Leveraging molecular data and metabolic host pathogen interactions to uncover antifungal resistance mechanismsJohannes Hartl Berlin Institute of Health at Charit Germanynot available on demand09 45 10 15Evolution of drug resistance in Mycobacterium tuberculosisVinay Nandicoori CSIR Centre for Cellular and Molecular Biology India10 15 10 30Extrachromosomal circular DNA as a mediator of rapid transient genetic adaptation in fungal pathogensJon Houseley Babraham Institute UK10 30 11 00Coffee Break Meet the speakers11 00 12 30Thursday morning session continued Chair Nassos Typas EMBL Heidelberg Germany11 00 11 30Phenotypic heterogeneity metabolic dormancy and survival to ofloxacin in E coliLaurence Van Melderen Universit Libre de Bruxelles Belgiumnot available on demand11 30 11 45The search for chemotherapeutic drugs driving the evolution of antimicrobial resistanceJ n na S unn Gu mundsd ttir UiT The Arctic University of Norway Norway11 45 12 15Oldies but goodies What makes beta lactams so effective Mariana Gomes de Pinho Instituto de Tecnologia Qu mica e Biol gica Portugal12 15 12 30mRNA translation as driver of acquired mutability of melanoma drug tolerant cellsLucilla Fabbri Institut Curie Universit Paris Saclay France12 30 14 00Lunch14 00 15 30Thursday afternoon sessionChair Mariana Gomes de Pinho Instituto de Tecnologia Qu mica e Biol gica Portugal14 00 14 15Microbial sensitivity changes to fungal derived antimicrobial proteins upon co cultivationGerlind Bauerecker University of Cologne Germany14 15 14 45Antibiotics of the future are prone to bacterial resistanceCsaba P l Biological Research Centre Szeged Hungary14 45 15 15Mechanistic insights into combinatorial stress adaptation in candida glabrata implications for antifungal resistance and pathogenicityJane Usher University of Exeter UK15 15 15 30High throughput method characterizes hundreds of previously unknown antibiotic resistance mutationsMatthew Jago University of Manchester UK15 30 16 00Coffee Break Meet the speakers16 00 17 20Thursday afternoon session continued Chair Marina Rodnina Max Planck Institute for Multidisciplinary Sciences Germany16 00 16 20A macroevolution inspired approach to reveal novel antibiotic resistance mechanismsLuiz Pedro Sorio de Carvalho The Herbert Wertheim UF Scripps Institute for Biomedical Innovation Technology USA16 20 16 35Gene amplification as a consequence of de novo acquisition of antibiotic resistanceXinyu Wang University of Amsterdam The Netherlandsnot available on demand16 35 17 05Single cell heterogeneity in bacterial tolerance and disease evolutionNathalie Balaban The Hebrew University of Jerusalem Israelnot available on demand17 05 17 20Predicting the emergence of clinically relevant antibiotic resistanceNancy Obeng F Hoffmann La Roche Ltd Germany17 20 19 00Poster Session 2 even numbers 19 00 21 00Gala dinner in EMBL Canteen21 00 00 00Party in ATC Foyer Day 4 Friday 21 March 2025 Time Europe Berlin Description09 00 10 30Friday morning sessionChair Markus Ralser Institute of Biochemistry at Charit Universit tsmedizin Berlin Germany09 00 09 30Acquisition of carbapenem resistance and hypervirulence in Klebsiella pneumoniaeYunn Hwen Gan National University of Singapore Singapore09 30 09 45The acquisition of antibiotic resistance associated mutations in different genetic backgroundsSidra Kashif Nottingham Trent University UK09 45 10 15Determinants and implications of antibiotic lethality in mycobacteriaLucas Boeck University of Basel Switzerland10 15 10 30Unraveling the complexity of collateral sensitivity based treatment in resistant Candida auris isolatesStef Jacobs KU Leuven Belgium10 30 11 00Coffee Break Meet the speakers11 00 12 30Friday morning session continued Chair Vinay Nandicoori CSIR Centre for Cellular and Molecular Biology India11 00 11 15Potential contribution of Type II toxin antitoxin systems to antibiotic induced persistence in Klebsiella pneumoniaeAndjela Rodic University of Belgrade Faculty of Biology Serbia11 15 11 45Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doublingCrispin Hiley University College Hospital Macmillan Cancer Centre UK11 45 12 00Microbial context dependence in the evolution of antibiotic resistant Klebsiella pneumoniaeMichael Knopp EMBL Heidelberg Germany12 00 12 15Adaptive laboratory evolution reveals the genetic determinants of alcohol tolerance in Staphylococcus aureus and the mechanisms that afford cross protection to vancomycin and other antibioticsSean Buskirk West Chester University USA12 15 12 30Closing Remarks and Poster Prize Announcements12 30 13 00Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Karoline Wolkersdorfer for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you 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deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBO EMBL Symposium from outside Europe The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further 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specific on site information A document with event specific information is available here Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the 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are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an 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developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually...

Judith Berman, Markus Ralser, Luiz Carvalho, Marina Rodnina

17 March - 21 March 2025

Gene-environment interactions in human health and disease

Description This introductory course explores the complex interplay between genes and the environment in shaping human phenotypes Participants will gain knowledge of cohort datasets environmental readouts and computational resources to investigate gene environment interactions Ethical and legal frameworks related to data privacy and consent will be discussed The course also covers computational modelling techniques for integrating genotype and environmental effects By the end attendees will be equipped to analyse cohort datasets make use of computational resources and interpret the results Please note that you will not analyse your own data as part of the course There will however be ample opportunity to discuss your research and ideas with other course participants and trainers...

Juanita Riveros

11 March - 14 March 2025

The expanding world of RBPs: from posttranscriptional control to riboregulation

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kitAirport strike information Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Based on recent methodological breakthroughs the number of identified mammalian RNA binding proteins RBPs has skyrocketed from around 700 to over 2000 More importantly completely new classes of proteins including enzymes signaling molecules transporters and channels etc were recognized as RBPs posing questions regarding the biological functions of RNA binding This meeting will bring together leaders in the field of RBPs classical and newly discovered and discuss exciting progress on all fronts from posttranscriptional regulation of RNA expression to the riboregulation of protein functions facilitated by rapidly emerging experimental technologies and data analysis tools Discussion topics will range from structural work over cell biology including RBP containing membraneless organelles metabolism and progress regarding human diseases The methodological spectrum will be equally wide and also include data analysis and AI modeling approaches Since this will be the first time that such a conference is organized community building or community extension from the established field of classical RBPs in posttranscriptional control to the emerging perspectives is also a major objective of the conference Topics Systems biology of RBPs experimental multi omics and data analysis Structure and function of RBPs including modelling AI Biological condensates Disease RBPs and new therapeutic angles New technologies to study RNA protein interactions Speakers Keynote Speakers Elena Conti Max Planck Institute of Biochemistry Germany Anthony Hyman Max Planck Institute of Molecular Cell Biology and Genetics Germany Speakers Minkyung Baek Seoul National University Republic of Korea Alfredo Castell MRC University of Glasgow Centre for Virus Research UK Ling Ling Chen Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell Science China Gideon Dreyfuss University of Pennsylvania School of Medicine USA Yoosik Kim Korea Advanced Institute of Science and Technology Republic of Korea Shinichi Nakagawa Hokkaido University Japan Karla Neugebauer Yale University School of Medicine USA Roy Parker University of Colorado Boulder USA Thomas Preiss Australian National University Australia Anna Pyle Yale University School of Medicine USA Cynthia Sharma Institute of Molecular Infection Biology Germany Gene Yeo University of California San Diego USA Elsa Zacco Istituto Italiano di Tecnologia Italy Scientific Organisers Francesca Cutruzzol Sapienza University of Rome Italy Imed Gallouzi King Abdullah University of Science and Technology Saudi Arabia Matthias Hentze EMBL Heidelberg Germany V Narry Kim Seoul National University Republic of Korea Event organiser Julia Patricia Nohle Course and Conference Officer EMBL Heidelberg Germany Programme Programme Are you on social media Post using EMBLRBP and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 11 March 2025 Time Europe Berlin Session15 00 16 30Registration and light refreshments16 30 16 45Opening remarks and welcome16 45 17 45Keynote lecture I Shaping the message mRNA binding proteins in contextElena Conti Max Planck Institute of Biochemistry GermanyNot available on demand17 45 18 45Keynote lecture II Phase separation and the role of RNA binding proteinsAnthony Hyman Max Planck Institute of Molecular Cell Biology and Genetics GermanyNot available on demand18 45 19 45Dinner in Canteen19 45 21 30After dinner drinks and Pub Quiz in Canteen Day 2 Wednesday 12 March 2025 Time Europe Berlin Session09 15 12 45Session 1 Systems Biology of RBPs experimental multi omics and data analysis Chair Elsa Zacco Italian Institute of Technology Italy09 15 09 45Regulation of eukaryotic RNA biogenesis by rapid co transcriptional RNA folding and remodeling by RBPsKarla Neugebauer Yale University School of Medicine USA09 45 10 00RNA binding proteins as mediators between genome evolution and gene regulationPetar Glazar Max Planck Institute for molecular Genetics Germany10 00 10 15The landscape of RNA binding proteins in mammalian spermatogenesis and human infertilityKe Zheng Nanjing Medical University China10 15 10 30STAU2 regulates speed of neurogenesis in vitro by affecting CHD2 and ARID3A gene regulatory networksAkshay Jaya Ganesh Bellvitge Institute for Biomedical Research SpainNot available on demand10 30 11 00Coffee Break and Meet the speakers11 00 11 30Links of 5 methylcytosine to RBP function in mRNA translation and turnoverThomas Preiss Australian National University Australia11 30 11 45Global 3 UTR lengthening upon PRMT inhibition reveals arginine methylation as a key regulator of alternative polyadenylationLlywelyn Griffith King s College London UK11 45 12 00Type I Interferon signalling causes a global remodelling of the cellular RNA bound proteomeLouisa Iselin University of Glasgow UK12 00 12 15Uncovering regulatory RNA elements in vertebrate virusesJenny Seo Seoul National University Republic of KoreaNot available on demand12 15 12 45Exploring the world of RNA binding proteins in bacterial pathogensCynthia Sharma Institute of Molecular Infection Biology GermanyNot available on demand12 45 14 00Lunch and Meet the speakers14 00 18 15Session 2 Structure and function of RBPs including modelling AI Chair Roy Parker University of Colorado Boulder USA14 00 14 30Panning for gold Discovering riboregulatory structures and RBP modules within viral genomes and eukaryotic mRNAsAnna Pyle Yale University School of Medicine USA14 30 14 45An integrated approach to deconvolute a full length mRNA 3 UTR regulated by the immunoregulatory multi domain RNA binding protein RoquinAndreas Schlundt Universit t Greifswald Germany14 45 15 00Structure based mechanism of riboregulation of the metabolic enzyme SHMT1Sharon Spizzichino Sapienza University of Rome Italy15 00 15 15Translation dependent regulation of mRNA stability by the ZC3H7A and ZC3H7B RNA binding proteinsPatric Harris Snell Queen s University Belfast UK15 15 15 45Prediction of RNA structures and their interactions using deep learningMinkyung Baek Seoul National University Republic of Korea15 45 16 15Coffee Break and Meet the speakers16 15 16 30eIF2A regulates cell migration in a translation independent mannerF tima Gebauer The Barcelona Institute of Science and Technology University of Pompeu Fabra SpainNot available on demand16 30 16 45Structural studies of nuclear cap binding complexes provide insights into RNA Pol II transcript fate determinationJan Kadlec Institut de Biologie Structurale FranceNot available on demand16 45 17 00Yeast phosphofructokinase subunit 2 has ATP dependent RNA unwinding activity and modulates cell cycle progressionAndr P Gerber University of Surrey UK17 00 17 30TOMM40 APOE chimera from Alzheimer s highest risk genes unusual RNA processing linking mitochondria oxidative stress and pathogenesis Virtual talk Gideon Dreyfuss University of Pennsylvania School of Medicine USA17 30 18 15Flash talk session 3 min 1 slide 159 Vicent Pelechano 76 Alice Coomer 155 Julian von Ehr 143 Ena Secic 119 Felix M ller 50 Albert Cairo 117 Makram Mghezzi Habellah 67 Tristan Espie Caullet 105 Alexia Le Barch 109 Federica Marasca 114 Victoria Mauz 128 Carlotta Penzo 141 Mauro Scaravilli 120 Rory Mulloy 90 Ilaria Piazza18 15 19 30Dinner in EMBL Canteen19 30 21 30Poster Session 1 odd numbers Day 3 Thursday 13 March 2025 Time Europe Berlin Session09 15 12 45Session 3 Biological condensatesChair Yoosik Kim Korea Advanced Institute of Science and Technology Republic of Korea09 15 09 45RNA binding proteins in RNP Granules and neurodegenerative diseasesRoy Parker University of Colorado Boulder USANot available on demand09 45 10 00Cellular dsRNA interactome reveals the regulatory map of exogenous RNA sensingJinA Lim Korea Advanced Institute of Science and Technology Republic of Korea10 00 10 15Intra condensate demixing of TDP 43 inside stress granules generates pathological aggregatesDavid Kuster Max Planck Institute of Molecular Cell Biology and Genetics Germany10 15 10 30WASP regulates the nucleolus and inflammatory response by controlling sub nuclear localization of the NPM1 HDAC1 complex through LLPSMo Li King Abdullah University of Science and Technology Saudi Arabia10 30 11 00Coffee Break and Meet the speakers11 00 11 30De novo assembly of nuclear stress bodies restrains acute inflammatory responsesLing Ling Chen Shanghai Institute of Biochemistry and Cell Biology China11 30 11 45RNA condensates in oocyte adaptation to quiescence and stressArnaud Hubstenberger CNRS C te d Azur University France11 45 12 00LINE1 RNA sustain the resting cell state by regulating ribosome biogenesis and chromatin organization through nuclear condensatesBeatrice Bodega Istituto Nazionale Genetica Molecolare INGM Italy12 00 12 15Tracking initiation of paraspeckle assembly in real timeKyungmin Baeg EMBL Heidelberg Germany12 15 12 45Regulation of pre mRNA splicing by super disordered proteinsShinichi Nakagawa Hokkaido University JapanNot available on demand12 45 14 15Lunch and Meet the editors14 15 19 15Session 4 Disease RBPs and new therapeutic anglesChair Thomas Preiss Australian National University Australia14 15 14 45Going out of phase RNA aptamers to interfere with and detect pathological protein condensationElsa Zacco Istituto Italiano di Tecnologia Italy14 45 15 00Understanding the Role of Pink1 mRNA Transport and Localization in Parkinson s DiseaseIsabel Geelhaar MPI Biological Intelligence Germany15 00 15 15The MYCN transcription factor is an RNA binding protein controlling transcript fateDimitrios Papadopoulos University of W rzburg GermanyNot available on demand15 15 15 30AUF1 gene therapy for muscle wasting diseasesRobert Schneider Regerna Therapeutics NYU School of Medicine USANot available on demand15 30 16 00Hidden heroes nuclear RNA binding proteins and their secret antiviral powersAlfredo Castello MRC University of Glasgow Centre for Virus Research UK16 00 16 30Coffee Break and Meet the speakers16 30 18 30Poster Session 2 even numbers 18 30 18 45Adaptation to disruption impact of extreme rRNA fragmentation on the Apicomplexan mitoribosomeShikha Shikha University of Glasgow UK18 45 19 00Unraveling mRNA stabilizing RBPs for optimal RNA designMin Ji Kim Korea Advanced Institute of Science and Technology Republic of Korea19 00 19 15Interfering with FUS protein aggregation with in silico designed RNA aptamersMartina Gilodi Italian Institute of Technology Italy19 15 19 45RNA binding protein protein interactomes Virtual talk Gene Yeo University of California San Diego USA19 45 20 45Conference dinner in the canteen20 45 00 30Party Day 4 Friday 14 March 2025 Time Europe Berlin Session10 30 12 00Session 5 New technologies to study RNA protein interactionsChair Cynthia Sharma University of W rzburg Germany10 30 11 00Unraveling molecular grammars of double stranded RNA recognitionYoosik Kim Korea Advanced Institute of Science and Technology Republic of KoreaNot available on demand11 00 11 15SoniCLIP a sonication based approach to globally identify target RNAs of RNA binding proteinsPia Sommerkamp EMBL Heidelberg GermanyNot available on demand11 15 11 30Spatially resolving RNA protein interactions with colocalization CLIPJoseph Luna Case Western Reserve University USA11 30 11 45High throughput mapping of modular regulatory domains in human RNA binding proteinsAbby Thurm Stanford University USA11 45 12 00Closing remarks12 00 12 45Packed lunch and departure Practical Information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 800On site PhD Student 700On site Industry 1000On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Julia Patricia Nohle for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact Julia Patricia Nohle for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 11 February 2025 in some cases at special rates Please email the hotel directly quoting the booking code RBP25 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event The bus schedule for the shuttle bus is available here Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin Vegetarier VegetarierinIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Bronze sponsor Event sponsor SiTOOLs Biotech Media partners Advanced Biology a Wiley journal Advanced Genetics a Wiley journal BioEssays a Wiley journal ChemBioChem a Wiley journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Journal of Cell Science The Company of Biologists journal Medinformatics a Bon View Publishing journal Molecular Systems Biology an EMBO Press journal Open Biology a Royal Society journalSponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl org for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 Airport strike information A nationwide strike by the trade union Ver di on Monday 10 March 2025 has brought air travel to a near standstill at 13 German airports including the Frankfurt hub Further details can be found here on the website of Frankfurt Airport Currently all air travel in and to Germany is affected We realise this could impact your journey to the EMBL Conference The expanding world of RBPs from posttranscriptional control to riboregulation The following information is to assist you in checking and adjusting travel plans to reach Heidelberg Please make sure to check with your airline and keep an eye on potential updates Arriving to Heidelberg Monday 10 March and Tuesday 11 March 2025 By bus or train All flights inbound to German airports will be severely disrupted on Monday and possibly Tuesday due to backlog Only very few services will run If you are able to rebook your flight to a neighboring European country you could look into taking the train or bus The strike affects only travel before and on the first day of the four day conference You will still be able to join if you arrive after the official registration session on day 1 as a last resort By car car sharing Car parking is available at EMBL Heidelberg We recommend connecting with other participants in advance is the Discussion area in the virtual platform for the conference Joining instructions for the virtual conference platform have been sent to you separately Important Please check with your hotel if parking is available and if a reservation is required FAQS 1 Is the conference still running as scheduled YES 2 I cannot travel to EMBL Heidelberg to attend the conference onsite due to the strike and none of the above options work for me All is not lost as a second best you can attend the conference as a virtual participant using the details previously sent The strike only affects travel before and on the first day of the four day conference 3 Can I get a refund if I cannot attend the conference Unfortunately not However you can still enjoy the conference as a virtual participant using the details previously sent 4 Does the strike affect local buses and trains No Public buses and trains will continue to operate as planned 5 Will the conference shuttle buses from Heidelberg hotels to EMBL still run Yes we are providing transport service as usual at specific times The shuttle schedule can be found here 6 Will airport personnel return to work on Friday check out day of the conference Yes The strike is expected to only last 24hrs starting on 10 March We will keep participants updated if this changes 7 Where can I connect with other participants to discuss transport arrangements An option for connecting with other participants in advance is the virtual platform for the conference under discussion menu Joining instructions for the virtual conference platform have been sent to you separately 8 If arriving directly to EMBL can I bring my luggage Yes there are lockers available on site to store your luggage There is another luggage room on level E0 which is free to use but remains unlocked during the conference Useful websites information Frankfurt Airport TRN Airport Transfer airport transfer provider Taxi Weinmann taxi company close to Heidelberg offering airport transfers Flixbus bus transfers across Germany Busradar long distance buses EMBL information for participants travelling to EMBL Heidelberg We hope you find the above helpful However if you still have a question that is not answered above please email us with any queries at events embl de or julia nohle embl de Please note Information is correct at the time of issue 10 March 2025 11 00 and is subject to change...

Francesca Cuttruzola, Imed Gallouzi, Matthias Hentze, V. Narry Kim

9 March - 14 March 2025

Quantitative proteomics: strategies and tools to probe biology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Proteomic technologies continue to develop at a rapid pace offering the potential to address imminent questions in a range of biological research areas Mass spectrometry has become widely accessible to many biologists either through core facilities or scientific collaborations Because quantitative proteomics includes a variety of specialised technologies and workflows each with specific advantages and limitations this hands on practical course aims to train biologists on how to best integrate these evolving proteomics technologies into their own research To achieve this expert tutors will offer hands on training in the analysis interpretation and statistical evaluation of various types of proteomic data through teaching methodological concepts integrated with software driven data analysis strategies This is complemented by theoretical training in concepts and methods presentations to illustrate application in various biological areas and a group challenge where applicants apply the acquired knowledge Finally emerging topics in the field will be presented by leading experts in immuno peptidomics structural proteomics and innovative ion mobility assisted proteomics Audience This course is aimed at researchers who know the basics of proteomics and who want to get a deeper understanding of quantitative methodologies and at those who are familiar with wet lab proteomic experimentation but want to gain experience in bioinformatic data interpretation To enter the course a basic understanding of mass spectrometry based proteomics is beneficial Modules resources The principles of proteome quantification by stable isotope labelling SILAC and TMT label free and targeted proteomics Introduction how various types of mass spectrometers can be used for proteome quantification Computer training sessions using software tools for the analysis of various quantitative proteomic data types Lectures demonstrating the application of quantitative proteomics in biology clinical research and drug discovery Learning outcomes Understand the principles and use cases of quantitative proteomic methods Ability to design quantitative proteomic experiments including selection of the most appropriate hardware and software Ability to analyse quantitative proteomic data with various software tools This event has been granted the following EMBO sustainability badge Grade 3 of 3 Speakers Speakers trainers and staff Miriam Abele Technical University Munich TUM Germany Michal Bassani Sternberg Ludwig Institute for Cancer Research Switzerland Ute Distler Johannes Gutenberg University Mainz Germany Dominic Helm German Cancer Research Center DKFZ Germany Yi Leo Hsiao University of Michigan Medical School United States of America Wolfgang Huber EMBL Heidelberg Germany Jeroen Krijgsveld German Cancer Research Center and Heidelberg University Germany Christina Ludwig Technical University Munich TUM Germany Lennart Martens VIB Ghent University Belgium Julia Mergner Technical University Munich TUM Germany Shabaz Mohammed University of Oxford United Kingdom Virtual speaker Alexey Nesvizhskii University of Michigan Medical School United States of America Paola Picotti ETH Zurich Switzerland Mikhail Savitski EMBL Heidelberg Germany Sarah Szvetecz Northeastern University United States of America Tim Van Den Bossche VIB Ghent University Belgium Olga Vitek Northeastern University United States of America Scientific organisers Jeroen Krijgsveld German Cancer Research Center and Heidelberg University Germany Christina Ludwig Technical University of Munich Germany Mikhail Savitski EMBL Heidelberg Germany Course organisers Swetlana Krez EMBL Heidelberg Germany Aline Schnieder EMBL Heidelberg Germany Programme Are you on social media Post using EMBOQuantPro and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 9 March 2025 Time Europe Berlin SpeakerLocation13 30Bus to EMBL ATCISG Hotel13 45 14 00Arrival and registrationCourtyard Room A B14 00 14 15Welcome and housenotesCourtyard Room A B14 15 15 00Introduction Quantitative proteomics for biologyJeroen Krijgsveld German Cancer Research Center GermanyChristina Ludwig Technical University Munich GermanyMikhail Savitski EMBL Heidelberg GermanyCourtyard Room A B15 00 16 00Flash talks 1 odd numbers Courtyard Room A B16 00 16 30Coffee breakCourtyard Room A B16 30 18 00Poster session with drinks and snacks odd numbers Helix B18 00 19 00DinnerEMBL Canteen19 00Bus to ISG HotelATC Entrance Day 2 Monday 10 March 2025 Time Europe Berlin SpeakerLocation08 40Bus to EMBL ATCISG Hotel08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Lecture MS technologiesDominic Helm German Cancer Research Center DKFZ GermanyCourtyard Room A B10 00 10 30Coffee breakCourtyard Room A B10 30 11 30Remote lecture Peptide chromatography in proteomicsShabaz Mohammed University of Oxford UKCourtyard Room A B11 30 12 30Lecture Peptide and protein identificationLennart Martens VIB UGent Center for MedicalBiotechnology Ghent University BelgiumCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 15 00Practical session 1 Peptide and protein identificationLennart Martens VIB UGent Center for Medical Biotechnology Ghent University BelgiumTim Van Den Bossche VIB UGent Center for Medical Biotechnology Ghent University BelgiumMiriam Abele Technical University Munich GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab15 00 15 30Coffee breakCourtyard Room A B15 30 17 00Practical session 1 cont Peptide and protein identificationLennart Martens VIB UGent Center for Medical Biotechnology Ghent University BelgiumTim Van Den Bossche VIB UGent Center for Medical Biotechnology Ghent University BelgiumMiriam Abele Technical University Munich GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab17 00 18 00Flash talks 1 even numbers Courtyard Room A B18 00 18 45Pizza dinnerATC Rooftop Lounge18 45 20 15Poster Session with drinks and snacks even numbers Helix B20 20Bus to ISG HotelATC Entrance Day 3 Tuesday 11 March 2025 Time Europe Berlin SpeakerLocation08 40Bus to EMBL ATCISG Hotel08 55 09 00Overview of the dayCourtyard Room A B09 00 10 30Lecture Introduction to label free quantitative proteomicsChristina Ludwig Technical University Munich GermanyCourtyard Room A B10 30 11 00Coffee breakCourtyard Room A B11 00 12 30Practical session 2 Label free protein quantification using SkylineMiriam Abele Technical University Munich GermanyJeroen Krijgsveld German Cancer Research Center GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyMikhail Savitski EMBL Heidelberg GermanyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 30Practical session 2 cont Label free protein quantification using SkylineMiriam Abele Technical University Munich GermanyJeroen Krijgsveld German Cancer Research Center GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyMikhail Savitski EMBL Heidelberg GermanyComputer Training Lab15 30 16 00Coffee breakCourtyard Room A B16 00 17 00Application talk 1 Versatility of SILAC labeling to understand proteome dynamicsJeroen Krijgsveld German Cancer Research Center DKFZ GermanyCourtyard Room A B17 00 18 00Treasure huntATC18 00 19 00DinnerEMBL Canteen19 00 21 00Pub quizATC Rooftop Lounge21 00Bus to ISG HotelATC Entrance Day 4 Wednesday 12 March 2025 Time Europe Berlin SpeakerLocation08 40Bus to EMBL ATCISG Hotel08 55 09 00Overview of the dayComputer Training lab09 00 10 00Lecture Introduction to FragPipe computational proteomics platformAlexey Nesvizhskii University of Michigan USAComputer Training lab10 00 10 30Coffee breakComputer Training Lab10 30 12 00Practical session 3 Analysis of quantitative proteomics data and PTM data with MSFragger and FragPipeAlexey Nesvizhskii University of Michigan USAYi Leo Hsiao University of Michigan USAMiriam Abele Technical University Munich GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Practical session 3 cont Analysis of quantitative proteomics data and PTM data with MSFragger and FragPipeAlexey Nesvizhskii University of Michigan USAYi Leo Hsiao University of Michigan USAMiriam Abele Technical University Munich GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab14 30 15 00Coffee breakComputer Training Lab15 00 16 00Good practices in scienceWolfgang Huber EMBL Heidelberg GermanyCourtyard Room A B16 00 17 00Open panel discussion agenda to be set by course participants Courtyard Room A B17 00 18 00Application talk 2 Biophysical proteomicsMikhail Savitski EMBL Heidelberg GermanyCourtyard Room A B18 05Free eveningBus downtown via ISG HotelATC Entrance Day 5 Thursday 13 March 2025 Time Europe Berlin SpeakerLocation08 40Bus to EMBL ATC08 55 09 00Overview of the dayCourtyard Room A B09 00 10 30Lecture Introduction to statistical analysis of proteomics dataOlga Vitek Northeastern University USAComputer Training lab10 30 11 00Coffee breakCourtyard Room A B11 00 12 30Practical session 4 Statistical analysis of proteomics data using MSStatsOlga Vitek Northeastern University USASarah Szvetecz Northeastern University USAMiriam Abele Technical University Munich GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 30Practical session 4 cont Statistical analysis of proteomics data using MSStatsOlga Vitek Northeastern University USASarah Szvetecz Northeastern University USAMiriam Abele Technical University Munich GermanyChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab15 30 16 00Coffee breakCourtyard Room A B16 00 17 00Application talk 3 Ion Mobility Assisted Data Independent Acquisition Mass SpectrometryUte Distler Johannes Gutenberg Universit t Mainz GermanyCourtyard Room A B17 05 17 45Bus downtown via ISGEMBL bus stop17 45 19 15Guided city tour19 15 22 00Course dinner downtown Day 6 Friday 14 March 2025 Time Europe Berlin SpeakerLocation08 40Bus to EMBL ATCISG Hotel08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Application talk 4 Antigen discovery using mass spectrometry based immunopeptidomicsMichal Bassani Sternberg Ludwig Institute for Cancer Research SwitzerlandCourtyard Room A B10 00 10 30Coffee break and Proteomics Core Facility tourCourtyard Room A B Proteomics Core Facility10 30 12 30Group Challenge Proteomics research topicCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 14 30Presentations from breakout session Panel discussionCourtyard Room A B14 30 15 30Application talk 5 Structural proteomicsPaola Picotti ETH Zurich SwitzerlandCourtyard Room A B15 30 15 45Course debrief and feedback with participantsCourtyard Room A B15 45Bus to train stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accomodation has been booked for you at the ISG Hotel for the default dates of 9 to 14 March 2024 5 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Jeroen Krijgsveld, Christina Ludwig, Mikhail Savitski

6 March 2025

UniProt for proteomics scientists

Description UniProt is a comprehensive expert led publicly available database of protein sequence function and variation information It also encompasses a wealth of large scale proteomics data resources and tools that users from the proteomics community can benefit from This webinar will introduce proteomics data in UniProt and highlight resources that users with large protein datasets may find useful in analysing their data This will encompass our proteomes service how to carry out a peptide search and where to find large scale proteomics derived data in UniProt The webinar will then go on to briefly introduce programmatic access to the UniProt Proteins API and will give examples on how to download reference proteomes and download large scale proteomics datasets programmatically Finally the speakers will take live questions from the audience Attendees will have access to a Google Colab workbook following the webinar which will provide coding examples that they can use in their own analysis pipelines The UniProt APIs are available at https www uniprot org help programmatic access...

5 March 2025

Developing a dataset for LLM projects

Description As large language models LLMs continue to revolutionise artificial intelligence applications the importance of high quality data preparation has never been more critical This webinar dives into the art and science of preparing datasets for effective LLM training offering actionable insights for AI practitioners data scientists and engineers We will explore the end to end process of data preparation beginning with data collection strategies and progressing through cleaning preprocessing tokenisation and annotation Emphasis will be placed on identifying and mitigating biases managing multilingual datasets and ensuring data quality and diversity to enhance model performance Real world case studies will illustrate common pitfalls and solutions while hands on demonstrations will provide practical techniques for optimising datasets Participants will gain a deeper understanding of how well structured and curated data can significantly impact an LLM s capabilities reduce training costs and improve ethical AI outcomes Whether you are building LLMs from scratch or fine tuning existing models this session will equip you with the knowledge to leverage your data assets effectively Join us to unlock the potential of data preparation and enable your LLMs to achieve unparalleled performance and generalisation...

3 March - 7 March 2025

Introduction to multi-omics data integration and visualisation

Description With the increase in the volume of data across the whole spectrum of biology more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences This may also include public domain data which can provide added value to data derived through the researcher s own work and inform experimental design This introductory course will highlight the challenges that researchers face in integrating multi omics data sets using biological examples The course will focus on the use of public data resources and open access tools for enabling integrated working with an emphasis on data visualisation This course will not include systems biology modelling or machine learning A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI data resource and research teams This allows participants to explore the bioinformatics tools and resources introduced in the course and to apply these to a set problem providing hands on experience of relevance to their own research The group work will culminate in a presentation session involving all participants on the final day of the course allowing wider discussion on the benefits and challenges of integrating data...

Meredith Willmott

27 February 2025

Workshop on Artificial Intelligence Competencies: training challenges and needs of research infrastructures and core facilities

Description Update the application period is closed but additional spaces may be available please contact the organisers if interested The Biodata Developers BioDev Network Wellcome Sanger Institute and ELIXIR EMBL EBI as part of RItrainPlus project are organising a knowledge exchange workshop on Artificial Intelligence Competencies training challenges and needs of research infrastructures and core facilities The overall purpose of the workshop is to create a space to discuss the professional roles and competencies needed to support the implementation of Artificial Intelligence AI for research in research infrastructures RIs Core Facilities CFs and similar organisations as well as the training gaps and current actions they are already carrying out to address the training needs This will be an interactive workshop where attendees will actively participate through discussions group work or short presentations The workshop has been shaped with the input gathered through dedicated scoping discussions with different experts In particular we would like to thank the following experts and their organisations for their input Nina Norgren SciLifeLabFotis Psomopoulos Center for Research and Technology HellasDan MacLean The Sainsbury Lab TSL Edward Lukyamuzi Pan African Mosquito Control Association PAMCA Dr Michelle Skelton Data Science for Health Discovery and Innovation in Africa DS I Africa Helder Nakaya Albert Einstein Hospitals BrazilMoises Sotelo University of GuadalajaraRolanda Julius Data Science for Health Discovery and Innovation in Africa DS I Africa...

Juanita Riveros

26 February 2025

Basics of Large Language Models - transformers to LLMs

Description We will introduce Large Language Models LLMs focusing on their core architecture training methodologies practical applications and some important considerations We begin with a brief exploration of the transformer architecture examining how architectural choices and scaling laws have shaped modern language models We then investigate key training paradigms with particular emphasis on Reinforcement Learning from Human Feedback RLHF and instruction tuning while briefly touching on emerging approaches like Direct Preference Optimisation DPO The discussion progresses through the evolution of knowledge integration techniques from basic context stuffing to Retrieval Augmented Generation RAG highlighting their practical implications We will discuss the critical issue of hallucinations in LLM outputs providing concrete examples and verification strategies To conclude a quick overview of the current software landscape and immediate future developments in the field and a look ahead to the rest of the webinar series...

24 February - 28 February 2025

Introduction to RNA-seq and functional interpretation

Description Gain an introduction to the technology data analysis tools and resources used in RNA sequencing and transcriptomics The content will provide a broad overview of the subject area and introduce participants to basic analysis of transcriptomics data using the command line It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data Topics will be delivered using a mixture of lectures practical exercises and open discussions Computational work during the course will use small example data sets and there will be no opportunity to analyse personal data Please note that this course covers different topics related to bulk RNA Seq data analysis Other related techniques such as single cell and spatial transcriptomics will not be covered Nonetheless the overview lecture will describe the potentials and limitations of the most commonly used RNA Sequencing analysis techniques and the context in which they are used If you are seeking training on single cell please consider applying to the 2025 Single cell RNA seq analysis with Python virtual course which will run about the same dates Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 08 00 18 00 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Barbara Etzi

23 February - 28 February 2025

Extracellular vesicles: from biology to biomedical applications

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The extracellular vesicle EV research field is still growing with many researchers entering the field with a continued strength of demand for such specialized training As research progresses it becomes clear that EV s regulate an increasing number of Patho physiological processes and are harnessed in a variety of biomedical applications Appropriate methodologies to prepare and characterize EV from biofluids are key to understanding the mechanisms that regulate their formation composition and function Given the large number of methods used it is particularly important to provide practical hands on training to new researchers covering the possibilities and limitations of the most widely used methods This course will deliver such state of the art training to participants particularly those entering the field and enable them to select the methodology which best fits their research question Audience This course is intended for PhD students and Postdoctoral researchers who are entering or are already active in the field of EV research and are interested in learning how to work with extracellular vesicles and know more about their biomedical applications Modules resources Extracellular vesicles continuous and discontinuous density gradient ultracentrifugation ultrafiltration techniques bead capture and precipitation techniques size exclusion chromatography SEC Extracellular vesicles characterisation Immunoblot and electron microscopy fluorescent labeling quantitative and qualitative analysis by flow cytometry nanoparticle tracking analysis in vivo imaging proteomic and transcriptomic analysis of EV Extracellular vesicles composition lipidomics proteomics transcriptomics Extracellular vesicles and function molecular players for extracellular vesicle biogenesis extracellular vesicle targeting to cells extracellular vesicles as diagnostics and or therapeutics in pathophysiology Learning outcomes In this course we intend to make PhD students and post doctoral researchers familiar with good practice guidelines and methods for purification and identification of extracellular vesicles with practical sessions included What past participants say about the course This course was very informative and covers all the major aspects of EV research It addresses questions of what level of quality is required for good publications but also offers relevant approaches towards analysing data and critical thinking in the EV field Whether you are taking your first steps in this field or more experienced this course applies to you Berglind Eva Benediktsd ttir University of Iceland Iceland My research is focused on understanding the role of exosomes in the progression of glioblastoma While working on exosome mediated regulation of angiogenesis in glioblastoma I found significant difficulties in getting a pure population of exosomes as it is often contaminated with other biomolecules As a result we were in delusion whether the data which we were getting was the effect of exosomes or other biomolecules Fortunately I found the EMBO Practical Course on extracellular vesicles focusing on the isolation and purification of extracellular vesicles which was extremely important for my research work We were trained to use cutting edge research tools for extracellular vesicles and learned bioinformatic analysis of biomolecules that are present in exosomes I also got an opportunity to interact with world leading researchers and discuss my research Abir Mondal National Centre for Cell Science India This event has been granted the following EMBO sustainability badge Grade 3 of 3 Speakers Speakers trainers and staff Markus Bergqvist University of Gothenburg Sweden Edit Buz s Semmelweis University Hungary Mickael Couty Centre de cancerologie et immunologie integree de Nantes Angers France Olivier De Wever Ghent University Belgium Peter Drent ONI Bio The Netherlands Mario Gimona Paracelsus Medical University Austria Andr G rgens Karolinska Institutet Sweden An Hendrix Ghent University Belgium Pradeep Kumar ONI Bio The Netherlands Maribel Lara Corona Institute of Psychiatry and Neuroscience of Paris France Cecilia L sser University of Gothenburg Sweden Alicia Llorente Oslo University Hospital Norway Estefania Lozano Andres Utrecht University The Netherlands Marianne Marchioni IZON France Lorena Martin Jaular Institut Curie Paris France Suresh Mathivanan La Trobe University Australia Esther Nolte t Hoen Utrecht University The Netherlands Michiel Pegtel Amsterdam UMC The Netherlands Claudio Pinheiro Ghent University Belgium Agatha Rosenthal Malvern Panalytical Germany Quentin Roux Centre de cancerologie et immunologie integree de Nantes Angers France Guillaume Van Niel Centre de cancerologie et immunologie integree de Nantes Angers France Scientific organisers An Hendrix Ghent University Belgium Cecilia L sser University of Gothenburg Sweden Esther Nolte t Hoen Utrecht University The Netherlands Guillaume Van Niel Centre de cancerologie et immunologie integree de Nantes Angers France Course organisers Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Irena Provaznikova Senior Scientific Training and Digital Learning Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBOEVs and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 23 February 2025 Time Europe Berlin SpeakerLocation15 30 16 00Arrival at Hotel ISGHotel ISG16 00 16 30Welcome and moderator for the day Cecilia L sser University of Gothenburg SwedenEMBL HousenotesCharlotte Courtney EMBL Heidelberg GermanyHotel ISG16 30 18 00All group activity Flash talks 2mins per participant and icebreaker challenges and expectations Hotel ISG18 00 19 00Lecture Heterogeneity in EV methodsAn Hendrix Ghent University Belgium Hotel ISG19 00 onwardsDinner and NetworkingHotel ISG Day 2 Monday 24 February 2025 Time Europe Berlin SpeakerLocation08 40Bus departure from ISG Hotel to EMBLISG Hotel entrance08 45 09 00Arrival at EMBL and coffeeATC09 00 09 15Overview of the day lab safety and introduction of speakersLab safety Irena Provaznikova EMBL Heidelberg Germany Moderator for the day An Hendrix Ghent University BelgiumCourtyard room09 15 09 45Lecture Heterogeneity in EV subtypesEdit Buzas Semmelweis University HungaryCourtyard room09 45 10 00Q A of previous lectureCourtyard room10 00 10 30Coffee breakCourtyard room10 30 11 00Introduction to practicals and preparation methodsAn Hendrix Ghent University BelgiumCourtyard room11 00 12 00Practical 1 Fluorescent labelling of EVs An Hendrix Ghent University BelgiumClaudio Pinheiro Ghent University BelgiumEsther Nolte t Hoen Utrecht University The NetherlandsCecilia L sser University of Gothenburg SwedenEstefan a Lozano Andres Utrecht University The NetherlandsMarkus Bergqvist University of Gothenburg SwedenTraining Lab A B12 00 13 00LunchEMBL Canteen13 00 13 30Lecture Fluorescent labelling of EVsLorena Martin Jaular Institut Curie FranceCourtyard room13 30 13 45Q A of previous lectureCourtyard room13 45 14 15Practical 1 continued An Hendrix Ghent University BelgiumClaudio Pinheiro Ghent University BelgiumEsther Nolte t Hoen Utrecht University The NetherlandsCecilia L sser University of Gothenburg SwedenEstefan a Lozano Andres Utrecht University The NetherlandsMarkus Bergqvist University of Gothenburg SwedenTraining Lab A B14 15 16 45Practical 2 EV preparation using density gradients An Hendrix Ghent University BelgiumClaudio Pinheiro Ghent University BelgiumEsther Nolte t Hoen Utrecht University The NetherlandsCecilia L sser University of Gothenburg SwedenTraining Lab A B16 45 17 15Coffee breakCourtyard room17 15 17 45Lecture EV biogenesisGuillaume Van Niel Centre de cancerologie et immunologie integree de Nantes Angers France Courtyard room17 45 18 00Q A of previous lectureCourtyard room18 00 19 00DinnerEMBL Canteen19 15Bus departure from EMBL to ISG HotelEMBL ATC entrance Day 3 Tuesday 25 February 2025 Time Europe Berlin SpeakerLocation08 40Bus departure from ISG Hotel to EMBLISG Hotel entrance08 45 09 00Arrival at EMBL and coffeeCourtyard room09 00 09 10Introduction of speakersModerator for the day Esther Nolte t Hoen Utrecht University The NetherlandsCourtyard room09 10 09 40Lecture Impact of pre analytical factors on EV preparation and characterizationCecilia L sser University of Gothenburg SwedenCourtyard room09 40 09 55Q A of previous lectureCourtyard room09 55 11 15Practical 3 EV preparation using size exclusion chromatography Marianne Marchioni IZON FranceAn Hendrix Ghent University BelgiumClaudio Pinheiro Ghent University BelgiumEsther Nolte t Hoen Utrecht University The NetherlandsCecilia L sser University of Gothenburg SwedenEstefan a Lozano Andres Utrecht University The NetherlandsMarkus Bergqvist University of Gothenburg SwedenPractical ONI carried out by trainers Surface PreparationCHIP demonstrationTraining Lab A B11 15 11 45Coffee breakONI Trainers continueCourtyard room11 45 12 45Continue Practical 2 Collect and process fractions from density gradients An Hendrix Ghent University BelgiumClaudio Pinheiro Ghent University BelgiumEsther Nolte t Hoen Utrecht University The NetherlandsCecilia L sser University of Gothenburg SwedenEstefan a Lozano Andres Utrecht University The NetherlandsMarkus Bergqvist University of Gothenburg SwedenONI Washing step Fixation BlockingTraining Lab A B12 45 13 30LunchEMBL Canteen13 30 13 45Course group photoTo be confirmed13 45 14 15Lecture Single EV analysisAndr G rgens Karolinska Institutet SwedenCourtyard room14 15 14 30Q A of previous lectureCourtyard room14 30 15 45Practical 4 Particle analysis Nanoparticle tracking analysisAgatha Rosenthal Malvern GermanySuper resolution microscopyPradeep Kumar and Peter Drent ONI Bio The NetherlandsHigh sensitivity flow cytometry Esther Nolte t Hoen Utrecht University The NetherlandsEstefan a Lozano Andres Utrecht University The NetherlandsRotation 1Training Lab A B15 45 16 15Coffee breakCourtyard room16 15 17 30Practical 4 Particle analysis Nanoparticle tracking analysisAgatha Rosenthal Malvern GermanySuper resolution microscopyPradeep Kumar and Peter Drent ONI Bio The NetherlandsHigh sensitivity flow cytometry Esther Nolte t Hoen Utrecht University The NetherlandsEstefan a Lozano Andres Utrecht University The NetherlandsRotation 2Training Lab A B17 30 18 45Practical 4 Particle analysis Nanoparticle tracking analysisAgatha Rosenthal Malvern GermanySuper resolution microscopyPradeep Kumar and Peter Drent ONI Bio The NetherlandsHigh sensitivity flow cytometry Esther Nolte t Hoen Utrecht University The NetherlandsEstefan a Lozano Andres Utrecht University The NetherlandsRotation 3Training Lab A B18 45 19 45Tapas dinnerATC Rooftop lounge19 45 21 20Poster session 1 with drinksATC Rooftop lounge top of Helix A21 20Bus departure from EMBL to ISG HotelEMBL ATC entrance Day 4 Wednesday 26 February 2025 Time Europe Berlin SpeakerLocation08 40Bus departure from ISG Hotel to EMBLISG Hotel entrance08 45 09 00Arrival at EMBL and coffeeCourtyard room09 00 09 10Introduction of speakersModerator for the day Cecilia L sser University of Gothenburg SwedenCourtyard room09 10 10 45Data analysis of NTA and Flow dataCourtyard room10 45 11 15Coffee breakCourtyard room11 15 11 45Lecture EV characterization by transmissionelectron microscopy and western blot analysisGuillaume Van Niel Centre de cancerologie et immunologie integree de Nantes Angers France Courtyard room11 45 12 00Q A of previous lectureCourtyard room12 00 13 00LunchEMBL Canteen13 00 13 30Lecture EVs in bacterial parasitic and viral infectionsEsther Nolte t Hoen Utrecht University The NetherlandsCourtyard room13 30 13 45Q A of previous lectureCourtyard room13 45 17 153 groups rotating 60 min per group Practicals 5 6 7 in parallel 3 groups rotatingGroup 1 EM Preparation Maribel Lara Corona training lab Group 2a EM Imaging remote Guillaume Van Niel EM facility Group 2b EM Imaging remote Mickael Couty EM facility Group 3 EV TRACK analysis An Hendrix Claudio Pinheiro Quentin Roux Virtual Training Lab A B EM Facility17 15 19 15Poster session 2 with drinksATC Rooftop lounge top of Helix A19 15 20 15Pizza dinnerATC Rooftop lounge20 15Bus departure from EMBL to ISG HotelEMBL ATC entrance Day 5 Thursday 27 February 2025 Time Europe Berlin SpeakerLocation08 40Bus departure from ISG Hotel to EMBLISG Hotel entrance08 45 09 00Arrival at EMBL and coffeeCourtyard room09 00 09 10Introduction of speakersModerator for the day Guillaume Van Niel Centre de cancerologie et immunologie integree de Nantes Angers FranceCourtyard room09 10 09 40Lecture ProteomicsSuresh Mathivanan La Trobe University Australia Virtual speaker Courtyard room09 40 09 55Q A of previous lectureCourtyard room09 55 11 15Practical 8 Bio informatics Suresh Mathivanan La Trobe University Australia Virtual speaker Computer Training Lab11 15 12 15Software tutorial superresolution microscopy and data analysisPradeep Kumar and Peter Drent ONI The NetherlandsComputer Training Lab ONI People12 15 13 15LunchCanteen13 15 13 45Lecture TranscriptomicsCl udio Pinheiro Ghent University BelgiumCourtyard room13 45 14 00Q A of previous lectureCourtyard room14 00 14 30Lecture LipidomicsAlicia Llorente Oslo University Hospital NorwayCourtyard room14 30 14 45Q A of previous lectureCourtyard room14 45 17 15Data analysis in groupsCourtyard room and FlexLabs A B17 15 17 45Lecture Preparation of EVs from different biofluidsOlivier De Wever Ghent University BelgiumCourtyard room17 45 18 00Q A of previous lectureCourtyard room18 00 18 30Bus transfer to the Aldstadt EMBL ATC entrance to the Heidelberg Aldstadt18 30 19 30Free timeHeidelberg Aldstadt19 30 22 00Course Dinner in Heidelberg AldstadtKulturbraurei Leyergasse 6 69117 Heidelberg Day 6 Friday 28 February 2025 Time Europe Berlin SpeakerLocation08 40Bus departure from ISG Hotel to EMBLISG Hotel entrance08 45 09 00Arrival at EMBL and coffeeCourtyard room09 00 09 10Introduction of speakersModerator for the day An Hendrix Ghent University BelgiumCourtyard room09 10 11 00 Final presentations by participants and discussionCourtyard room11 00 11 30Lecture EV clinical applicationsMario Gimona Paracelsus Medical University AustriaCourtyard room11 30 11 45Q A of previous lectureCourtyard room11 45 12 15Lecture In vivo function of EVsMichiel Pegtel Amsterdam UMC The NetherlandsCourtyard room12 15 12 30Q A of previous lectureCourtyard room12 30 14 30Meet the expert with lunch in the ATC Rooftop loungeATC Rooftop Lounge14 30 15 00Debrief by organisers feedback and closeCourtyard room15 20Shuttle bus from EMBL to the Heidelberg train stationEMBL ATC entrance Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission and all course materials Academia 500PhD Student 500Industry 1 100 Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of Sunday 23 February to Friday 28 February 2025 5 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 24 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Course partners Course sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

An Hendrix, Cecilia Lässer, Esther Nolte-T Hoen, Guillaume Van Niel

17 February - 21 February 2025

Advanced deep learning for image analysis

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The advent of deep learning has brought a revolution in the field of computer vision including most tasks and research questions concerned with microscopy image analysis Neural networks have been successfully used for image restoration classification and segmentation for the detection of objects and characterisation of their morphology and for high throughput imaging and large scale processing in 3D Despite these advances training and deployment of such neural networks remains difficult for practitioners of image analysis The aim of our course is to close this gap and teach the participants in the most hands on way possible to apply deep learning based methods to their own data and image analysis problems This time we aim not to start from scratch but to address participants who already had their first experience training a network in their own code either in a course or through their own experimentation Together we will troubleshoot and debug evaluate more advanced methods and learn about the state of the art in the field Audience This course is aimed at both core facility staff and research scientists Prerequisites for this workshop are programming experience in Python including solid knowledge of operations with images and first experience of applying deep learning algorithms Learning outcomes Understand the fundamentals of applying deep learning to image analysis in microscopy Learn where the state of the art of the field stands for the most important image analysis problems Advise users colleagues in strategies to obtain ground truth Select and train a neural network on a bioimage analysis task Devise a validation strategy for the results Modules resources Segmentation for 2D and 3D from scratch and finetuning Tracking Generative models for image restoration and beyond What past participants say about the course I attended the Deep Learning course and I couldn t be happier with that decision The venue the instructors the content and the organization was excellent Social interactions were on par definitely a great experience Alberto D ez CEMIR NTNU Norway I recently attended the Deep learning for Image analysis course at EMBL and I cannotexpress enough how immensely useful informative and enjoyable it was The course not only gives the participants a complete overview and understanding of existing tools and techniques through lectures given by experts in the field but it also provides them with the opportunity to apply these techniques on their own data and scientific problem I really appreciated the overall hands on approach and I am extremely grateful for the trainers help throughout the practicals Camille Lambert EPFL Switzerland Speakers Speakers trainers and staff Anwai Archit University of G ttingen Germany Elena Buglakova EMBL Heidelberg Germany Federico Carrara Human Technopole Italy Albert Dominguez Mantes EPFL Switzerland Anna Foix Romero EMBL EBI United Kingdom Jan Funke HHMI s Janelia Research Campus USA Florian Jug Human Technopole Italy Alexander Kelleher EMBL Heidelberg Germany Anna Kreshuk EMBL Heidelberg Germany Alexander Krull University of Birmingham United Kingdom Constantin Pape University of G ttingen Germany Hyoungjun Peter Park EMBL Heidelberg Germany Benjamin Salmon University of Birmingham United Kingdom Ruggiero Santeramo Human Technopole Italy Yi Sun EMBL Heidelberg Germany Joshua Talks EMBL Heidelberg Germany Martin Weigert Dresden University of Technology Germany Igor Zubarev Human Technopole Italy Scientific organisers Florian Jug Human Technopole Italy Anna Kreshuk EMBL Heidelberg Germany Constantin Pape University of G ttingen Germany Martin Weigert Dresden University of Technology Germany Course organisers Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Programme Got something to say Post it EMBLDeepLearning Pre course work will be needed ahead of the three mandatory virtual webinars that will take place before the course Further details will be shared in advance of the course and materials will be available on the EMBL eCampus platform The purpose of the webinars is to get everyone to the level from which we can start trying things on real data Programme is preliminary and subject to change Pre course webinar 1 Monday 13 January 2025 Pre course webinar 2 Monday 20 January 2025 Pre course webinar 3 Monday 3 February 2025 Day 1 Monday 17 February 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL ATC EntranceISG Hotel08 55 09 20Arrival and registrationCourtyard Room A B09 20 09 40Welcome house notes and course overviewCourtyard Room A B09 40 10 40TAs present themselves and the problems they are working onCourtyard Room A B10 40 11 10Coffee breakCourtyard Room A B11 10 12 10Participants present their data and problem at hand 2 min each Courtyard Room A B12 10 13 00LunchEMBL Canteen13 00 14 00Lecture Useful tricks tools and practices interactive session Florian Jug Human Technopole ItalyAnna Kreshuk EMBL Heidelberg GermanyConstantin Pape University of G ttingen GermanyMartin Weigert Dresden University of Technology GermanyCourtyard Room A B14 00 18 00Practical Focus on Own Data ICourtyard Room A B Flex Lab A Flex Lab B Computer Training Lab18 00 19 00DinnerEMBL Canteen19 00 19 15Bus to ISG HotelATC entrance Day 2 Tuesday 18 February 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the day SegmentationCourtyard Room A B09 00 10 00Lecture SegmentationAnna Kreshuk EMBL Heidelberg GermanyCourtyard Room A B10 00 10 15Coffee breakCourtyard Room A B10 15 11 00Lecture Existing segmentation tools and how to extend themFlorian Jug Human Technopole ItalyAnna Kreshuk EMBL Heidelberg GermanyConstantin Pape University of G ttingen GermanyMartin Weigert Dresden University of Technology GermanyCourtyard Room A B11 00 11 30Coffee break and discussionCourtyard Room A B11 30 12 30Practical Focus on own data IICourtyard Room A B Flex Lab A Flex Lab B Computer Training Lab12 30 13 30LunchEMBL Canteen13 30 18 00Practical Focus on own data IICourtyard Room A B Flex Lab A Flex Lab B Computer Training Lab18 00 19 00DinnerEMBL Canteen19 00 19 15Bus to ISG HotelATC entrance Day 3 Wednesday 19 February 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the day TransformerCourtyard Room A B09 00 10 00Lecture Introduction to Transformers and applicationsConstantin Pape University of G ttingen GermanyCourtyard Room A B10 00 10 15Coffee breakCourtyard Room A B10 15 11 00Lecture Transformers for trackingMartin Weigert Dresden University of Technology GermanyCourtyard Room A B11 00 11 30Coffee break and discussionCourtyard Room A B11 30 12 30Practical Focus on Own Data III or FlexProject I play with transformers Courtyard Room A B Flex Lab A Flex Lab B Computer Training Lab12 30 13 20LunchEMBL Canteen13 20 13 35Group photo13 35 17 55Practical Focus on Own Data III or FlexProject I play with transformers Courtyard Room A B Flex Lab A Flex Lab B Computer Training Lab17 55 18 25Bus to DowntownATC entrance18 25 19 55Free timeHeidelberg Downtown19 55 21 55Dinner DowntownVetter s Alt Heidelberger Brauhaus Day 4 Thursday 20 February 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the day GenerativeAICourtyard Room A B09 00 10 00Lecture Introduction to Generative modelsAlexander Krull University of Birmingham United KingdomCourtyard Room A B10 00 10 15Coffee breakCourtyard Room A B10 15 11 00Lecture Generative models for image restoration channel unmixing and other tasksFlorian Jug Human Technopole ItalyCourtyard Room A B11 00 11 30Coffee break and discussionCourtyard Room A B11 30 12 30Practical Focus on Own Data IV or Flex Project II play with generative models Courtyard Room A B Flex Lab A Flex Lab B Computer Training Lab12 30 13 30Lunch breakEMBL Canteen13 30 18 00Practical Focus on Own Data IV or Flex Project II play with generative models Courtyard Room A B Flex Lab A Flex Lab B Computer Training Lab18 00 18 45Pizza dinnerATC Rooftop Lounge18 45 19 45Roundtable discussion Technologies to watchATC Rooftop Lounge19 45 20 00Bus to ISG HotelATC entrance Day 5 Friday 21 February 2025 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the dayCourtyard Room A B09 00 09 45Practical ConclusionCourtyard Room A B10 05 10 35Coffee break and discussionCourtyard Room A B10 35 12 05Preparation for group presentationCourtyard Room A B Flex Lab A Flex Lab B Computer Training Lab12 05 12 50LunchEMBL Canteen12 50 14 20Group activity Presentations by the participants what worked what didn t what could be done nextCourtyard Room A B14 20 14 40Coffee breakCourtyard Room A B14 40 16 10Group activity Presentations by the participants what worked what didn t what could be done nextCourtyard Room A B16 10 16 25Wrap up and DeparturesCourtyard Room A B16 25 16 45Bus to Heidelberg Train StationATC entrance Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 715PhD Student 715Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 5 nights from Sunday 16 to Friday 17 February at ISG hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with the code MAC25 01 by the deadline of Thursday 16 January 2025 We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Media partners Microcscopy and Analysis a Wiley journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Anna Kreshuk, Florian Jug, Constantin Pape, Martin Weigert

17 February - 21 February 2025

Single-cell RNA-seq analysis with Python

Description This course covers the analysis of single cell RNA sequencing scRNA seq data using Python and command line tools Participants will be guided through droplet based scRNA seq analysis pipelines from raw reads to cell clusters You will explore and interpret single cell RNA seq data using Python as well as the Single Cell Expression Atlas Finally you will put their knowledge into practice through a group challenge on the last day Please note that you will not analyse your own data as part of the course There will however be ample opportunity to discuss your research and ideas with other course participants and trainers Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning you will not require access to a powerful computer or install complex software on your own machines Participants will need to be available between the hours of 09 00 17 30 BST each day of the course Trainers will be available to assist answer questions and provide further explanations during these times Please note that we will operate this course virtually Hybrid options are not currently available We reserve the right to change the format of this course or cancel it...

Juanita Riveros

13 February 2025

Sequence analysis tools in UniProt: BLAST and Align

Description UniProt provides the scientific community with a freely accessible collection of protein sequences and functional information and is one of the most widely used protein resources in the world BLAST and the multiple sequence alignment are essential methods commonly used to find and compare protein or nucleotide sequences In this webinar we will demonstrate how you can access and run these sequence analysis tools in UniProt We will also show you how to navigate the results and how you can exploit UniProt protein annotation to expand further the analysis of your results...

9 February - 14 February 2025

In situ CLEM at room temperature and in cryo

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The course is designed to equip participants with both practical hands on skills in Correlative Light and Electron Microscopy CLEM and a solid theoretical foundation This advanced imaging modality enables researchers to precisely locate fluorescent proteins within cellular ultrastructures a technique pioneered at the European Molecular Biology Laboratory EMBL Recognizing the increasing demand for in situ CLEM applications the training is geared towards enabling attendees to create customised CLEM workflows to address their unique research questions and share this knowledge within their institutions Our course delves into the specifics of this method emphasising high precision localization Furthermore it offers significant interaction with CLEM and EM experts facilitating rich discussions and troubleshooting sessions This ensures that participants not only learn the methodology but also gain insightful actionable guidance to apply CLEM techniques effectively in their research endeavors Audience This course targets core facility staff emerging group leaders exploring the featured methods and PhD students and post doctoral researchers employing these techniques Participant selection is based on i The course s expected impact on the applicant s research trajectory ii Proficiency in electron microscopy iii Availability of relevant equipment at the applicant s home institution or nearby Modules resources High pressure freezing Freeze substitution Plunge freezing and micropatterning Ultramicrotomy Light microscopy room temperature and in cryo Aquisition and image registration using Serial EM and Icy Tailored in depth practicals Project consultation Learning outcomes Participants will gain hands on experience with the CLEM methods learn tips and become familiar with the people who developed the methods and network with the experts What past participants say about the course The course was excellent All the lectures were spot on with a lot of practical information I felt very lucky that I could attend the course Paulina Cherek University of Exeter UK It is a great practical course because I can learn new techniques and feel confident that I can do it after returning to my home institution Also knowing that I will be able to contact the experts if help is needed Thank you Xinran Liu Yale University USA This event has been granted the following EMBO sustainability badge Grade 1 of 3 Speakers Speakers trainers and staff Petr Chlanda Heidelberg University Germany Martin Fritsch Leica Microsystems Germany Kar Ho Herman Fung University of Michigan USA Mathilda Hjoerdis Lennartz Max Planck Institute of Molecular Cell Biology and Genetics Germany Steffen Klein EMBL Heidelberg Germany Pedro Machado Oxford Instruments UK Giulia Mizzon Universitaetsklinikum Heidelberg Germany Soheil Mojiri EMBL Heidelberg Germany Viola Oorschot EMBL Heidelberg Germany Perrine Paul Gilloteaux University of Nantes France Andreia Pinto Leica Microsystems Germany Paolo Ronchi EMBL Heidelberg Germany Nadav Scher The Weizmann Institute of Science Israel Yannick Schwab EMBL Heidelberg Germany Anna Steyer EMBL Heidelberg Germany L a Swistak Institut Pasteur France Zhengyi Yang EMBL Heidelberg Germany Evgenia Zagoriy EMBL Heidelberg Germany Scientific organisers Ori Avinoam The Weizmann Institute of Science Israel Mandy Boermel EMBL Heidelberg Germany Rachel Mellwig EMBL Heidelberg Germany Course organisers Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOCLEM and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 9 February 2025 Time Europe Berlin SpeakerLocation14 00 15 00Welcome house notes and course overviewISG Hotel15 00 16 00Lecture 1 How to choose your CLEM approachOri Avinoam Weizmann Institute of Science IsraelISG Hotel16 00 16 30Coffee BreakISG Hotel16 30 18 00Flash TalksISG Hotel18 00 19 00Lecture 2 In situ CLEM WorkflowRachel Mellwig EMBL Heidelberg GermanyISG Hotel19 00DinnerISG Hotel Day 2 Monday 10 February 2025 Time Europe Berlin SpeakerLocation08 40 09 00Transfer to EMBL from ISG HotelISG Hotel09 00 09 30Check in safety briefing and presentation on responsible conduct in research RCR Flex Lab A B09 30 10 30Lecture 3 Correlative multi modal imaging in three dimensionsYannick Schwab EMBL Heidelberg GermanyFlex Lab A B10 30 10 45Coffee break Meet the SpeakersFlex Lab A B10 45 11 45Lecture 4 Tips and tricks to adapt on section CLEM to diverse biological questionsMandy Boermel EMBL Heidelberg GermanyFlex Lab A B11 45 12 45Lecture 5 Strategies for cryoEM sample preparationEvgenia Zagoriy EMBL Heidelberg GermanyFlex Lab A B12 45 13 30LunchEMBL Canteen13 30 18 30Practical 1A High pressure freezingAnna Steyer EMBL Heidelberg GermanyAndreia Pinto Leica Microsystems GermanyPractical 1B Freeze substitutionPaolo Ronchi EMBL Heidelberg GermanyOri Avinoam The Weizmann Institute of Science IsraelPractical 1C Plunge freezingZhengyi Yang EMBL Heidelberg GermanyL a Swistak EMBL Heidelberg GermanyPractical 1D MicropatterningIevgeniia Zagoriy EMBL Heidelberg GermanyHerman Fung University of Michigan USA18 30 19 30DinnerEMBL Canteen19 30 19 45Transfer to ISG Hotel from EMBLATC Entrance Day 3 Tuesday 11 February 2025 Time Europe Berlin SpeakerLocation08 40 09 00Transfer to EMBL from ISG HotelISG Hotel09 00 10 00Lecture 6 Tricks and pitfalls in ultramicrotomyViola Oorschot EMBL Heidelberg GermanyAndreia Pinto Leica Mycrosystems GermanyFlex Lab A B10 00 11 00Lecture 7 Cryo CLEM to study virusesPetr Chlanda University of Heidelberg GermanyFlex Lab A B11 00 11 15Coffee break Meet the SpeakersFlex Lab A B11 15 12 15Lecture 8 In block fluorescence imaging for FIB SEM targetingPaolo Ronchi EMBL Heidelberg GermanyFlex Lab A B12 15 13 00LunchEMBL Canteen13 00 19 00Practical 2A Ultramicrotomy at room temperatureAndreia Pinto Leica Microsystems GermanyViola Oorschot EMBL Heidelberg GermanyPractical 2B Light microscopy on plastic sectionsPaolo Ronchi EMBL Heidelberg GermanyPractical 2C Cryo light microscopy LSM900 Zeiss Anna Steyer EMBL Heidelberg GermanyZhengyi Yang EMBL Heidelberg GermanyPractical 2D Cryo light microscopy Leica Stellaris Martin Fritsch Leica Microsystems GermanyIevgeniia Zagoriy EMBL Heidelberg Germany19 00 19 20Transfer to ISG Hotel from EMBLATC Entrance19 20 20 20Dinner ISG Hotel Day 4 Wednesday 12 February 2025 Time Europe Berlin SpeakerLocation08 40 09 00Transfer to EMBL from ISG HotelISG Hotel09 00 10 45Lecture 9 Quantifying UA within your sample using EDS Pedro Machado Oxford Instruments UKFlex Lab A B09 45 10 45Practical 3A SerialEM demonstration with Remote TEM sessionOri Avinoam The Weizmann Institute of Science IsraelMandy Boermel EMBL Heidelberg GermanyPaolo Ronchi EMBL Heidelberg GermanyRachel Mellwig EMBL Heidelberg GermanyComputer Training Lab10 45 11 00Coffee break Meet the SpeakersComputer Training Lab11 00 12 00Practical 3B SerialEM hands onMandy Boermel EMBL Heidelberg GermanyPaolo Ronchi EMBL Heidelberg GermanyRachel Mellwig EMBL Heidelberg GermanyOri Avinoam The Weizmann Institute of Science IsraelGiulia Mizzon Universitaetsklinikum Heidelberg GermanyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 15 00Practical 3C Icy and ec CLEMPerrine Paul Gilloteaux University of Nantes FranceNadav Scher EMBL Heidelberg GermanyComputer Training Lab15 00 15 15Coffee break Meet the SpeakersComputer Training Lab15 15 15 45Debrief Wrap up of first round of practicals that have introduced the entire workflow Q AComputer Training Lab15 45 16 00Group photo16 00 16 45Transfer to Downtown with a stop at ISG Hotel ATC Entrance16 45 19 00Free time in Heidelberg city centre19 00 22 00Course dinnerVetter s Alt Heidelberger Brauhaus Day 5 Thursday 13 February 2025 Time Europe Berlin SpeakerLocation08 40 09 00Transfer to EMBL from ISG HotelISG Hotel09 00 10 00Lecture 10 Lessons Learned from 3D CLEMNadav Scher Weizmann Institute of Science IsraelFlex Lab A B10 00 10 15Coffee break Meet the SpeakersFlex Lab A B10 15 11 00Lecture 11 Room temperature CLEM Success StoryMathilda Lennartz Max Planck Institute of Molecular Cell Biology and Genetics GermanyFlex Lab A B11 00 11 45Lecture 12 Cryo CLEM Success StoryL a Swistak EMBL Heidelberg GermanyFlex Lab A B11 45 12 20LunchEMBL Canteen12 20 13 00EMBL Imaging Centre and TREC truck 13 00 19 00Practical 4A HPF and FS more in depthRachel Mellwig EMBL Heidelberg GermanyOri Avinoam The Weizmann Institute of Science IsraelViola Oorschot EMBL Heidelberg GermanyPractical 4B In depth software hands on session ICY SerialEM MoBIE Perrine Paul Gilloteaux University of Nantes FranceHerman Fung University of Michigan USANadav Scher EMBL Heidelberg GermanyPractical 4C Ultramicrotomy including serial sectioningViola Oorschot EMBL Heidelberg GermanyMandy Boermel EMBL Heidelberg GermanyPractical 4D Cryo light microscopy hands on sessionAnna Steyer EMBL Heidelberg GermanyMartin Fritsch Leica Microsystems GermanySteffen Klein EMBL Heidelberg GermanyZhengyi Yang EMBL Heidelberg GermanyPractical 4E Relate software demoPedro Machado Oxford Instruments UKPractical 4F Demo of the cryo super resolution microscopeSoheil Mojiri EMBL Heidelberg GermanyPractical 4G In block fluorescence imagingPaolo Ronchi EMBL Heidelberg Germany19 00 20 00DinnerEMBL Canteen20 00 20 15Transfer to ISG Hotel from EMBLATC Entrance Day 6 Friday 14 February 2025 Time Europe Berlin SpeakerLocation08 40 09 00Transfer to EMBL from ISG HotelISG Hotel09 00 10 30Round table discussions on open questions students explain implementations for their own projectsFlex Lab A B10 30 10 45Coffee break Meet the SpeakersFlex Lab A B10 45 11 45Round table discussions on open questions students explain implementations for their own projectsFlex Lab A B11 45 12 15Lecture 13 Outlook 3D CLEM in cryoSteffen Klein EMBL Heidelberg GermanyFlex Lab A B12 15 12 30Coffee break Meet the SpeakersFlex Lab A B12 30 13 00Lecture 14 Outlook Probes for cryo CLEMHerman Fung University Michigan USAFlex Lab A B13 00 13 30Lecture 15 Outlook Super Resolution cryo CLEMSoheil Mojiri EMBL Heidelber GermanyFlex Lab A B13 30 13 45Feedback and FarewellFlex Lab A B13 45 14 00Packed Lunch14 00Transfer from EMBL to Heidelberg train station and city centerATC Entrance Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waivers The fee waiver will cover the registration sum that you have paid to attend the course Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 8 to 14 February In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Technical requirements Basic familiarity with light and electron microscopy techniques Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Virtual participation guidelines Guidelines Do not broadcast the course to unregistered participants Do not share your login details with others You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in eCampus for you to enjoy during the event How to ask questions Questions during and after the talks can be asked in the live streaming platform If time runs out or you think of a question later you can use the EMBL eCampus forum or send a direct message to the speaker trainer Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated As many virtual participants are attending from around the world we do our best to accommodate as many time zones as possible when creating the programme Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Media partners Microcscopy and Analysis a Wiley journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Ori Avinoam, Mandy Bormel, Rachel Mellwig

5 February 2025

Explore small molecules in the PDB easily using PDBe-KB Ligand Pages

Description The Protein Data Bank PDB is a global archive containing over 200 000 experimentally determined 3D structures of biomolecules like proteins DNA and RNA Interestingly about 75 of these structures also include small molecules ligands which play vital roles such as cofactors reactants or inhibitors drugs Each structure deposited in the PDB is assigned a unique PDB ID and provides valuable details such as 3D coordinates structure data quality and information about small molecules bound to the structure However understanding how the same small molecule interacts across different structures can be challenging as ligand related data is scattered across various PDB entries Aggregating and comparing this data is often necessary to gain meaningful insights and address various biological questions To bridge this gap PDBe presents novel PDBe KB Ligand Pages that aggregate and summarise all structure data for each ligand in PDB These pages offer a comprehensive view of each ligand covering chemical structural interaction and functional details They aggregate key data including bound structures and proteins PDB wide ligand protein interaction statistics and related ligands Additionally the pages provide details such as molecular descriptors 2D 3D structural view cross links to external databases like ChEMBL PubChem and DrugBank for further exploration This unified resource enables users to easily explore and analyse ligand data across the PDB In this webinar we will showcase the features of PDBe KB Ligand Pages and guide you on how to use them to uncover scientific insights about small molecules in the PDB...

4 February - 7 February 2025

In situ structural biology: expanding the toolbox for structural cell biology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview There is an increasing awareness that mechanistic understanding of complex cellular functions and interactions requires structural knowledge of the macromolecules involved Recent technological advances in several disciplines nurture the development of in situ structural biology approaches that have separately started to provide structural information on molecules within the context of intact cells in order to fully grasp how they function in their native environment These include cryo electron microscopy and tomography EM ET mass spectrometry based proteomics fluorescence and super resolution light microscopy protein structure prediction multi scale computational modelling and others This conference aims to bring together experts and early stage researchers from the separate disciplines as well as researchers from different fields in the Life Sciences to highlight recent methodological developments and to promote their usage as new tools for cell biology across scales from molecules to organelles cells and cell cell interactions to provide a discussion platform for structural biology methods within the cellular context to stimulate discussions about how to meaningfully integrate data from different methods to define what types of biological questions can already be addressed using in situ structural biology and which might be approached in the future Topics Molecular machines and macromolecular assemblies Novel technologies 1 advanced imaging Organelles and compartments Single cell systems Cellular interactions and multi cellular systems Novel technologies 2 computational and data integration What past participants say about the conference The conference was fantastic with an amazing list of speakers As an early career researcher I found these events very inspirational and broadening for research opportunities later Kamila Kamuda University College London UK I immensely benefited from the workshop organized by EMBL through talks of so many brilliant scientists who had explained the fast evolving technique to capture the whole cell structure at the near atomic resolution Samar Ballabha Mohapatra Indian Institute of Technology India This event has been granted the following EMBO sustainability badge Grade 3 of 3 Speakers Keynote Speakers Pedro Beltrao ETH Zurich Switzerland Jennifer Lippincott Schwartz Janelia Research Campus USA Speakers Toshio Ando Kanazawa University Japan Martin Beck Max Planck Institute of Biophysics Germany Pedro Beltrao ETH Zurich Switzerland Enrica Bordignon University of Geneva Switzerland Ignacia Echeverria University of California San Francisco USA Virginie Hamel University of Geneva Switzerland Ralf Jungmann Max Planck Institute of Biochemistry and Ludwig Maximilians University of Munich Germany Suliana Manley EPFL Switzerland Siewert Jan Marrink University of Groningen Netherlands Tetiana Serdiuk ETH Zurich Switzerland Thom Sharp University of Bristol UK Felix Sigmund Technical University of Munich Germany Elizabeth Villa University of California San Diego USA Miao Yu Wuhan University China Ellen Zhong Princeton University USA Scientific organisers Julia Mahamid EMBL Heidelberg Germany Jonas Ries University of Vienna Austria Stefano Vanni University of Fribourg Switzerland Conference organiser Chris Stocks Course and Conference Team Lead EMBL Heidelberg Germany Programme Are you on social media Post using EMBOinsitu and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 4th February 2025 Time Europe Berlin Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 14 45Keynote lectureImaging mRNA translation from micron to atomic scalesJennifer Lippincott Schwartz Janelia Research Campus USA14 45 18 30Session 1 Molecular machines and macromolecular assembliesChair Julia Mahamid EMBL Heidelberg Germany14 45 15 00Stepwise assembly of axonemes visualised through cryo electron tomography of the ciliary tip Helen Foster Human Technopole Italy15 00 15 15Explorations with cryo ET AI structure prediction and XL MS to reveal the molecular components of motile ciliaCaitlyn McCafferty University of Basel Switzerland15 15 15 30MINFLUX tracking for monitoring stepping dynamics of kinesin 1 in live cellsTakahiro Deguchi EMBL Heidelberg Germany15 30 16 00How Bcl xL catches Bid at the mitochondrial membrane to inhibit apoptosisEnrica Bordignon University of Geneva Switzerland16 00 16 30Coffee break and Meet the speakers16 30 17 00Integrative modeling of compositional and conformationally heterogeneous protein assembliesIgnacia Echeverria University of California San Francisco USA17 00 17 15From 2D live cell images to a 3D model how to get structural information in living cellsAltair Chinchila Hernandez Pompeu Fabra University Spain17 15 17 30Bridging scales methods and expertise an integrative computational modeling strategy to study structure dynamics and function of molecular machinesTill Rudack University of Regensburg Germany17 30 18 00How do molecular modules act in concert to generate complex cellular functions Martin Beck Max Plank Institute of Biophysics Germany18 00 18 15Mechanism of RNA polymerase II elongation complex condensationRichard Stefl Masaryk University Czech Republic18 15 18 30In situ structure and arrangement of the mitochondrial oxidative phosphorylation machinery in whole cellsLea Dietrich Max Planck Institute for Brain Research GermanyNot available on demand18 30 20 00Dinner in canteen20 00 22 00Pub quiz and after dinner drinks Day 2 Wednesday 5th February 2025 Time Europe Berlin Speaker 09 00 12 00 Session 2 Novel Technologies 1 advanced imagingChair Jonas Reis University of Vienna Austria09 00 09 30Combined DNA nanotechnology with single molecule fluorescence methods for high resolution microscopy techniquesRalf Jungmann Max Plank Institute of Biochemistry and LMU Germany09 30 09 45Correlating cryo electron tomography ultrastructure with super resolution fluorescence imaging using post acquisition expansion microscopyNikolai Klena Human Technopole Italy09 45 10 00Registration free approach for the guidance of cryogenic focused ion beam milling beyond the axial diffraction limitPeter Dahlberg SLAC National Accelerator Laboratory USA10 00 10 30Coffee break and Meet the speakers10 30 11 00High speed AFM for dynamic structural biologyToshio Ando Kanazawa University JapanNot available on demand11 00 11 15An optimized cryo lift out procedure for studying biomolecular condensates by in situ cryo electron tomographyGaia Perone Human Technopole Italy11 15 11 30Phase contrast in cryo STEM tomographyPeter Kirchweger Weizmann Institute of Science Israel11 30 12 00Imaging intracellular components in situ using superresolution cryo correlative light and electron microscopyThomas Sharp University of Bristol UK12 00 13 30Lunch and Meet the Editors13 30 16 30Session 3 Organelles and CompartmentsChair Enrica Bordignon University of Geneva Switzerland13 30 14 00Connecting and compartmentalizing the mitochondrialcollective through bridging and pearlingSuliana Manley EPFL SwitzerlandNot available on demand14 00 14 15Structural elucidation of TORC2 regulation by plasma membrane macrodomainsElda Bauda University of Geneva Switzerland14 15 14 30Bridging cryo ET and molecular modelling at membrane contact sites Veijo Salo EMBL Heidelberg GermanyJennifer Sapia University of Fribourg Switzerland14 30 15 00Coffee break and meet the speakers15 00 15 30Unraveling centriole assembly using cryo electron tomography and expansion microscopyVirginie Hamel University of Geneva Swtizerland15 30 15 45Topography and in situ structure of neuronal AMPA receptor scaffolding complexes visualized by cryo electron tomographyRichard Held Stanford University USA15 45 16 00Decoding the molecular properties of selective autophagic cargo in situJavier Lizarrondo Diaz de Cerio Max Planck Institute of Biophysics GermanyNot available on demand16 00 16 30Flash talk session 49 Anton Leonie 55 Toru Fujiwara 61 Bonjour Kennedy 71 Wioleta Dudka 77 Monica Fernandez Monreal 81 Florian Walter Hofer 99 Uljana Kravcenko 105 Jiasui Liu 107 Hisham Maza l 109 Yuliia Mironova 111 Soheil Mojiri 115 Mara M ller 131 Elena Shmakova 137 Thomas Trainer 143 Florent Waltz16 30 18 30Poster session 1 odd numbers Poster numbers here18 30Free evening Day 3 Thursday 6th February 2025 Time Europe Berlin Speaker09 00 11 45 Session 4 Single cell systemsChair Suliana Manley EPFL Switzerland09 00 09 30Visualizing the conformation and dynamics of FG nucleoporins in live cellsMiao Yu Wuhan University China09 30 09 45Human spermatogenesis leads to a reduced nuclear pore structure and functionAlia dos Santos MRC Laboratory of Molecular Biology UK09 45 10 00Capturing endogenous ligands of lipid transfer proteins by native mass spectrometryCarla Kirschbaum University of Oxford UK10 00 10 15Harnessing whole cell imaging to dissect organelle interdependencies and define cell anatomy a two pronged approachMary Mirvis University of California San Francisco USA10 15 10 45Coffee break and Meet the speakers10 45 11 00Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neuronsJana Kroll Max Delbr ck Center for Molecular Medicine Germany11 00 11 15CoVET Cryo electron tomography guided by optical electrophysiologyMingyu Jung Seoul National University Republic of Korea11 15 11 30Visualizing the in situ structure of tau filaments in an iPSC neurodegenerative disease modelMaxwell Tucker University of California San Francisco USA11 30 12 00Computational microscopy of whole cells and cell organellesSiewert Jan Marrink University of Groningen The Netherlands12 00 13 30Lunch Job Fair13 30 18 45Session 5 Cellular Interactions and multicellular systemsChair Martin Beck Max Plank Institute of Biophysics Germany13 30 14 00Structure activity relationship of disease specific alpha synuclein fibrillar polymorphsTetiana Serdjuk ETH Zurich SwitzerlandNot available on demand14 00 14 15A generalisable and targeted molecular biopsy approach for in situ cryo electron tomography of vitreous brain tissueCalina Glynn Rosalind Franklin Institute UK14 15 14 30Genetic and biochemical regulation of crystal morphogenesis in zebrafish iridophoresDvir Gur Weizmann Institute of Science Israel14 30 15 00Coffee break and Meet the speakers15 00 15 15In cell structure and snapshots of copia retrotransposons in intact tissue by cryo electron tomographySven Klumpe Max Planck Institute of Biochemistry Germany15 15 15 30In situ studies of plant invasion by fungal pathogensJuan Carlos De la Concepcion Austrian Academy of Sciences Austria15 30 16 00Combining cell biology and electron microscopy image processing and physical modeling to understand macromolecules in complex scenariosElizabeth Villa UCSD USAVirtual Talk16 00 16 45Flash talk session 50 Shreyas Arvindekar 58 Laura Isabel Betancur Ocampo 64 Sergio Cruz Leon 70 Joe Dobbs 76 Niko Faul 84 P ter G r g 92 kenneth Fahy 96 Oliwia Koczy 98 Iuliia Kotova 100 Jan Philipp Kreysing 102 Samuel Lacey 104 Sebastian Tacke 106 Matthew Lycas 110 Vera Moiseenkova Bell 118 Sonia Oren 120 Davis Perez 128 Jenny Sachweh 132 Aakanksha Singh 140 Melina Vallbracht16 45 18 45Poster session 2 even numbers Poster number here18 45 20 45Conference dinner in the canteen20 45 00 00Party with live band The Wright Thing Day 4 Friday 7th February 2025 Time Europe Berlin Speaker09 30 13 00Session 6 Novel Technologies 2 computational and data integrationChair Stefano Vanni University of Fribourg Switzerland09 30 09 45Integrative dynamic modeling of complex molecular mechanisms from 3D animation to agent based simulationMargot Riggi Max Planck Institute of Biochemistry Germany09 45 10 15Novel Genetically Encoded Tools for Multiplexed Labeling in Electron MicroscopyFelix Sigmund Technical University of Munich Germany10 15 10 30Surface morphometrics 2 0 mapping local membrane bilayer thickness in the cellMichaela Medina The Scripps Research Institute USA10 30 11 00Coffee break and Meet the speakers11 00 11 15CryoSiam self supervised deep learning model for macromolecular identification of in cell cryo electron tomographyFrosina Stojanovska EMBL Heidelberg Germany11 15 11 45Machine learning methods for computational and structural biology problems with a focus on protein structure determination by cryo EM ETEllen Zhong Princeton University USAPresented onsite by Rishwanth Raghu Princeton University USA11 45 12 45Keynote lectureApplications and limitations of modelling biomolecular interactions with AlphaFoldPedro Beltrao ETH Zurich Switzerland12 45 13 00Closing remarks and poster prize announcements13 00Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 770On site Journal Editors 300Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Christopher Stocks for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 03 January 2025 in some cases at special rates Please email the hotel directly quoting the booking code ISS25 01 to confirm the exact price of the room Hotel AnlageHotel Ibis HeidelbergPremier Inn Heidelberg CityB B HotelLeonardo Hotel Heidelberg City CentreHilton HeidelbergExzellenz HotelMeininger Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the conference shuttle bus schedule here updated 05 February 2025 The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Heidelberg HBF EMBL Haustelle Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Hans B ckler Stra e Bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsorDectrisMedia partners ChemBioChem a Wiley journal EMBO Reports an EMBO Press journal FEBS Open Bio a FEBS Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journalSponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Julia Mahamid, Jonas Ries, Stefano Vanni

30 January 2025

Automated annotation in UniProt

Description UniProt is a high quality comprehensive protein resource in which the core activity is the expert review and annotation of proteins where the function has been experimentally investigated At the same time the UniProt database contains large numbers of proteins which are predicted to exist from gene models but which do not have associated experimental evidence indicating their function UniProt commits significant resources to developing computational methods for functional annotation of these predicted proteins based on the data in entries that have gone through the expert review process We will describe the two main automated annotation systems currently in use First UniRule which is an established UniProt system in which curators manually develop rules for annotation Second ARBA Association Rule Based Annotator which is a multi class learning system which uses rule mining techniques to generate concise annotation models ARBA employs a data exclusion algorithm that censors data not suitable for computational annotation and generates human readable rules for each UniProt release As part of our interest in engaging with the machine learning community we will also introduce the contribution of ProtNLM Protein Natural Language Model from Google Research which annotates proteins which have uncharacterised names We will also introduce UniFIRE an open source software that enables researchers to annotate their own protein dataset by using the above mentioned annotation systems In order to provide an easy and straightforward way to download and set up this tool we have containerised UniFIRE together with all its dependencies and the latest set of UniRule and ARBA rules In this webinar we will show how to create functional predictions for protein sequences by using this container image...

29 January 2025

Introducing the new Ensembl Genome Browser

Description Ensembl creates and imports genome annotations including data on genes variations regulation and comparative genomics for vertebrates non vertebrates and key model organisms providing this information freely online This webinar will provide an introduction to the new Ensembl browser platform and demonstrate how to navigate the website to retrieve genomic data The new browser is also home to all data that would previously have been shared on the Ensembl Rapid Release site The webinar will highlight the improvements in the new platform and how these enhancements can significantly aid in genomic research Importantly participants will also be able to engage with the Ensembl outreach team to find sources of help and documentation...

27 January - 31 January 2025

Computing skills for reproducible research: software carpentry

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Computation is an integral part of today s research as data has grown too large or too complex to be analysed by hand An ever growing fraction of science is performed computationally but many scientists struggle with this aspect of research as they have not been properly trained in the necessary set of skills The result is that too much time is spent doing steps manually or using inefficient tools when progress could be faster This course provides training in several key tools with a focus on good development practices that encourage efficient and reproducible research computing Audience This course is aimed at researchers in the life sciences who wish to use or design analysis pipelines on individual or clusters of computers The target learner is familiar with some command line programmatic computer usage and wants to become more confident using these tools efficiently and reproducibly If you have written a for loop in some language before but do not know what Git or Nextflow is or at least are not very comfortable using them you may be the perfect fit for this workshop Modules Resources Introduction to the Unix shell Version control and history tracking with Git Introduction to scripting and basics of data analysis with Python Multi step analysis and pipeline management with Nextflow Best practices for reproducible analysis in high performance computing environments Learning outcomes After the workshop participants will be able to interact with a command line shell for local and remote computing needs write and organise their own scripts for data analysis use version control to keep track of and revert changes to their files implement efficient and reproducible pipelines that combine multiple tools and scripts execute and troubleshoot command line tools and pipelines on a high performance computing cluster Participant commitment There will be an onboarding session one week before the course starts to make sure everyone has installed the required software and that everyone to a good starting position for the 5 day hybrid course in January 2025 Full time attendance is required for the course duration Speakers Speakers trainers and staff Renato Alves EMBL Heidelberg Germany Anastasiia Grekova EMBL Heidelberg Germany Julian Hennies EMBL Heidelberg Germany Jean Karim H rich EMBL Heidelberg Germamy Sarah Kaspar EMBL Heidelberg Germany Dominik Kutra EMBL Heidelberg Germany Jacobo Miranda EMBL Heidelberg Germany Lisanna Paladin EMBL Heidelberg Germany Felix Schneider EMBL Heidelberg Germany Christian Schudoma EMBL Heidelberg Germany Francesco Tabaro EMBL Heidelberg Germany Christian Tischer EMBL Heidelberg Germany Thomas Weber EMBL Heidelberg Germany Mahnoor Zulfiqar EMBL Heidelberg Germany Scientific organisers Renato Alves EMBL Heidelberg Germany Lisanna Paladin EMBL Heidelberg Germany Christian Schudoma EMBL Heidelberg Germany Course organisers Iva Gavran Course and Conference Officer EMBL Heidelberg Germany Ellen Malovrh Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLSoftwareCarpentry and don t forget to tag EMBLEvents Please note the below programme is still subject to changes Some pre course work such as installing software with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Onboarding session Tuesday 21 January 2025 Time Europe Berlin SpeakerLocation15 00 17 00Onboarding session mandatory Virtual Day 1 Monday 27 January 2025 Time Europe Berlin SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Coffee break and computer set upCourtyard Room A B09 00 09 30Arrival housenotes and course overviewCourtyard Room A B09 30 10 30Flashtalks from all participantsCourtyard Room A B10 30 10 50Coffee breakCourtyard Foyer10 50 12 20Intro to ShellCourtyard Room A B12 20 13 20LunchEMBL Canteen13 20 14 20Intro to ShellCourtyard Room A B14 20 14 40Coffee breakCourtyard Foyer14 40 16 10Intro to GitCourtyard Room A B16 10 16 30Coffee breakCourtyard Foyer16 30 17 30Intro to GitCourtyard Room A B17 30 18 00Daily feedbackCourtyard Room A B18 00 19 00Social activity19 00 20 00DinnerEMBL Canteen20 00 20 10Departure to HotelATC Entrance Day 2 Tuesday 28 January 2025 Time Europe Berlin SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Coffee break and computer set upCourtyard Room A B09 00 10 30Intro to PythonCourtyard Room A B10 30 11 00Coffee breakCourtyard Foyer11 00 12 00Intro to PythonCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Intro to PythonCourtyard Room A B14 00 14 30Coffee breakCourtyard Foyer14 30 16 00Intro to PythonCourtyard Room A B16 00 16 30Coffee breakCourtyard Foyer16 30 18 00Intro to PythonCourtyard Room A B18 00 18 30Daily feedbackCourtyard Room A B18 30 19 30DinnerEMBL Canteen19 30 19 40Departure to HotelATC Entrance Day 3 Wednesday 29 January 2025 Time Europe Berlin SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Coffee break and computer set upCourtyard Room A B09 00 10 30Intro to PythonCourtyard Room A B10 30 11 00Coffee breakCourtyard Foyer11 00 12 00Intro to PythonCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Intro to PythonCourtyard Room A B14 00 14 30Coffee breakCourtyard Foyer14 30 16 00Command line scripting with PythonCourtyard Room A B16 00 16 30Coffee breakCourtyard Foyer16 30 18 00Command line scripting with PythonCourtyard Room A B18 00 18 30Daily feedbackCourtyard Room A B18 30 19 30DinnerEMBL Canteen19 30 19 40Departure to HotelATC Entrance Day 4 Thursday 30 January 2025 Time Europe Berlin SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Coffee break and computer set upCourtyard Room A B09 00 10 30Intro to SLURM with NextflowCourtyard Room A B10 30 11 00Coffee breakCourtyard Foyer11 00 12 00Intro to SLURM with NextflowCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Intro to SLURM with NextflowCourtyard Room A B14 00 14 30Group photo and coffee breakCourtyard Foyer14 30 16 00Intro to SLURM with NextflowCourtyard Room A B16 00 16 30Daily feedbackCourtyard Room A B16 30 17 00World of Molecular Biology tour for onsite participants onlyImaging centre17 00 17 45Bus to city centre with a stop at ISG hotel 17 45 19 00Free time19 00 21 30Downtown dinner Day 5 Friday 31 January 2025 Time Europe Berlin SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Coffee break and computer set upCourtyard Room A B09 00 10 30Best practices in HPC environmentCourtyard Room A B10 30 11 00Coffee breakCourtyard Foyer11 00 12 00Best practices in HPC environmentCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 14 00Best practices in HPC environmentCourtyard Room A B14 00 15 00Debrief and wrap upCourtyard Foyer15 00 15 30Bus to train station and downtownATC Entrance Practical information Registration fees and motivation letter The course is limited to 15 virtual and 15 onsite participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Onsite registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to live streamed course content lectures practical sessions discussion rounds as well as any learning activities in the virtual learning platform OnsiteVirtualAcademia 425 190PhD Student 425 190Industry 750 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waivers The fee waiver will cover the registration sum that you have paid to attend the course Childcare grants There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For some events applications for Childcare Grants will still be done by email Information about the grant will be sent out shortly after the abstract motivation letter deadline Please contact the event Conference Officer if you have any questions Selection The scientific organisers will select the recipients of registration fee waivers during the participant selection process for courses Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Further details Check out this list of external funding opportunities For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 5 nights from 26 to 31 January 2025 at the ISG hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course e g SWC25 01 by the deadline of 26 December 2024 We recommend that all course participants stay at the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course You will need admin rights to be able to install the software on your computer and we recommend you try this before the course If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed Below you will find the software and technical requirements for this course On site participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software All participants will be requested to install software before the course Please make sure to bring the laptop with the installed software to the course You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Additional software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Other information While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Virtual participation guidelines Guidelines Do not broadcast the course to unregistered participants Do not share your login details with others You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in eCampus for you to enjoy during the event How to ask questions Questions during and after the talks can be asked in the live streaming platform If time runs out or you think of a question later you can use the EMBL eCampus forum or send a direct message to the speaker trainer Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated As many virtual participants are attending from around the world we do our best to accommodate as many time zones as possible when creating the programme Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Renato Alves, Lisanna Paladin, Christian Schudoma

15 January 2025

An introduction to EMBL-EBI resources

Description EMBL EBI is the home of the world s most comprehensive range of freely available molecular databases and resources Our resources help researchers share and analyse data and perform complex queries in many different ways Join us for a tour of the core data resources at EMBL EBI During this webinar we will introduce the types of data available how you can search for data and the various ways of getting assistance We will also discuss the role of EMBL EBI in making data open and accessible and how you can include EMBL EBI data in your workflows We will also provide information on further online training to help you learn more about specific topics in bioinformatics and EMBL EBI resources including an introduction to the training collections The collections bring together videos and online tutorials on a specific topic to help get started...

14 January - 16 January 2025

Primer for predocs 2025

Description This course is aimed to provide an orientation for new predocs to EMBL EBI Databases and services will be introduced along with other useful information for starting out at EMBL EBI...

Juanita Riveros

11 December 2024

Uncovering protein function with UniProt

Description UniProt provides the scientific community with a freely accessible collection of protein sequence and functional information and is one of the most widely used protein resources in the world This webinar will cover what functional information is available in UniProt and where that information comes from It will also describe how the information is added to the resource and how to find it on the UniProt website...

4 December 2024

Calculating polygenic scores with the Polygenic Score Catalog Calculator

Description Polygenic scores PGS are a measurement which represents genetic predisposition for a heritable trait or phenotype by aggregating the effects of hundreds to millions of genetic variants into a single number The PGS Catalog is the world s largest FAIR finable accessible interoperable and reusable repository of PGS along with the relevant metadata required to evaluate and reuse them PGS have emerged as a commonly used genomic tool that have multiple research applications and potential clinical applications This webinar will demonstrate how to use scoring files from the PGS Catalog or custom files to calculate PGS in your own samples using the PGS Catalog Calculator pgsc calc The pgsc calc software reproducibly automates PGS calculation in commonly used genotyping formats plink VCF alongside capabilities for adjusting PGS in the context of genetic ancestry necessary for proper interpretation of PGS across diverse populations This webinar introduces the software and describes the ancestry adjustment process included in the Calculator along with information about how to run the tool and interpret results...

3 December - 6 December 2024

Hands-on course for sample preparation and data analysis in proteomics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The course will give an introduction to the theoretical aspects of the analysis of proteins peptides by mass spectrometry Participants will get hands on experience in sample preparation for a quantitative comparison across samples and perform a state of the art sample preparation and tandem mass tag labelling Samples prepared by the participants will be measured by liquid chromatography tandem mass spectrometry In a session focused on bioinformatics analysis participants will use FragPipe and FragPipe Analyst in order to process the acquired data Audience The course is intended for scientists that use or want to use proteomics for their research Applicants should have an understanding of protein biology and should know the principle of proteomics Ideally they have some prior experience with proteomics either directly or through collaborators or facilities Modules Sample preparation and data acquisition Introduction to MS technology Useful online tools for proteomics Applications in proteomics TMT history theory and applications Experimental design principles From spectra to spreadsheet tables with FragPipe Data assessment quality control from spreadsheet outputs Differential abundance analysis with FragPipe Analyst Learning outcomes State of the art sample preparation Learning which aspects of sample preparation can influence the outcome of the experiment Getting insights into different proteomics applications Optimal experimental design Basic understanding of data analysis Visualisation of proteomics data Speakers Speakers trainers and staff Isabelle Becher EMBL Heidelberg Germany Mira Burtscher EMBL Heidelberg Germany Per Haberkant EMBL Heidelberg Germany Dominic Helm German Cancer Research Center DKFZ Germany Sarah Kaspar EMBL Heidelberg Germany Michal Nadler Holly Thermo Fisher Scientific Germany Mandy Rettel EMBL Heidelberg Germany Mikhail Savitski EMBL Heidelberg Germany Suparat Scheu EMBL Heidelberg Germany Jennifer Schwarz EMBL Heidelberg Germany Frank Stein EMBL Heidelberg Germany Scientific Organisers Mandy Rettel EMBL Heidelberg Germany Mikhail Savitski EMBL Heidelberg Germany Frank Stein EMBL Heidelberg Germany Event organisers Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Julia Patricia Nohle Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLProteomics and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Tuesday 3 December 2024 Time Europe Berlin ProgrammeLocation09 00 09 15Registration and welcomeFlex Lab A B09 15 09 45Introduction to EMBL and housenotes incl Lab safetyFlex Lab A B09 45 10 15Course overview and introduction to Proteomics Core FacilityFlex Lab A B10 15 10 45Icebreaking activity Flash talks by participants Flex Lab A B10 45 11 00Coffee BreakFlex Lab A B11 00 12 00Lecture Sample preparationMandy Rettel EMBL Heidelberg GermanyFlex Lab A B12 00 13 00LunchEMBL Canteen13 15 14 30Practical 1 Cell lysis Solubility assayPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyIsabelle Becher EMBL Heidelberg GermanyTraining Lab B14 30 15 15Practical 2 Protein determination by Tryptophan assayPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyIsabelle Becher EMBL Heidelberg GermanyTraining Lab B15 15 15 45Coffee breakFlex Lab A B15 45 17 15Practical 3 Reduction alkylation SP3 protocol digestion including photosession with internal Photographer no participation required Per Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyIsabelle Becher EMBL Heidelberg GermanyTraining Lab B17 15 18 15MS gameFlex Lab A B Training Lab B18 15 19 45DinnerEMBL Canteen Day 2 Wednesday 4 December 2024 Time Europe Berlin ProgrammeLocation09 00 09 15Overview of the dayFlex Lab A B Training Lab B09 15 10 10Practical 4 Peptide extraction TMT labellingPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyIsabelle Becher EMBL Heidelberg GermanyTraining Lab B10 10 10 20Coffee breakFlex Lab A B10 20 10 50Lecture TMT theory and technical aspects Michal Nadler Holly Thermo Fisher Scientific GermanyFlex Lab A B10 50 11 30Lecture TMT applicationMikhail Savitski EMBL Heidelberg GermanyFlex Lab A B11 30 12 30Practical 5 Quenching Multiplexing Sample desaltingPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyIsabelle Becher EMBL Heidelberg GermanyTraining Lab B12 30 13 30Lunch breakEMBL Canteen13 30 15 00Lecture Introduction to MS technologyDominic Helm German Cancer Research Center DKFZ GermanyFlex Lab A B15 00 15 30Q A session with coffeeFlex Lab A B15 30 16 00Practical 6 Load samples on Mass specPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyIsabelle Becher EMBL Heidelberg GermanyProteomics Core Facility16 00 16 30Lecture Workflow overviewFrank Stein EMBL Heidelberg GermanyFlex Lab A B16 30Free evening Day 3 Thursday 5 December 2024 Time Europe Berlin ProgrammeLocation09 00 09 15Overview of the dayComputer Training Lab09 15 09 40Lecture Raw file analysis with FreestyleMichal Nadler Holly Themo fisher scientific GermanyComputer Training Lab09 40 10 30Lecture Raw file processing with FragPipeFrank Stein EMBL Heidelberg GermanyComputer Training Lab10 30 10 50Coffee breakComputer Training Lab10 50 12 00Computer Practical Analysis of own data with FragpipePer Haberkant EMBL Heidelberg Germany Mandy Rettel EMBL Heidelberg Germany Jennifer Schwarz EMBL Heidelberg Germany Frank Stein EMBL Heidelberg GermanyMira Burtscher EMBL Heidelberg GermanyComputer Training Lab12 00 13 00Lunch breakcourse photo around 12 50 EMBL Canteen13 00 14 00Lecture What data can tell you about your experimental workflow Frank Stein EMBL Heidelberg GermanyComputer Training Lab14 00 14 25Coffee breakComputer Training Lab14 25 16 15Lecture Practical Experimental designSarah Kaspar EMBL Heidelberg GermanyComputer Training Lab16 15 16 40Coffee breakComputer Training Lab16 40 17 40Computer Practical Usage of bioinformatics toolsPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyMira Burtscher EMBL Heidelberg GermanyComputer Training Lab17 45 18 00Bus from EMBL downtown18 00 19 00Heidelberg Christmas market19 00 21 30Dinner downtown Day 4 Friday 6 December 2024 Time Europe Berlin ProgrammeLocation09 00 09 15Overview of the dayFlex Lab A B09 15 10 30Lecture Quantitative and statistical data analysis workflowFrank Stein EMBL Heidelberg GermanyComputer Training Lab10 30 10 50Coffee breakComputer Training Lab10 50 11 30Computer Practical Fragpipe AnalystPer Haberkant EMBL Heidelberg GermanyMandy Rettel EMBL Heidelberg GermanyJennifer Schwarz EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyMira Burtscher EMBL Heidelberg GermanyComputer Training Lab11 30 12 30Lecture Applications in proteomicsPer Haberkant EMBL Heidelberg GermanyFlex Lab A B12 30 13 30LunchEMBL Canteen13 30 14 15Lecture PhosphoproteomicsJennifer Schwarz EMBL Heidelberg GermanyFlex Lab A B14 15 15 30Q A session Discussion of individual projects with PCFFlex Lab A B15 30 16 00Tour of Imaging Centre Exhibition World of Molceular Biology Imaging Centre16 15Bus to Heidelberg train station and city center Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 575PhD Student 575Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 4 nights 2 6 December 2024 at ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with booking code SDP24 01 by the deadline of Tuesday 5 November 2024 We recommend that all course participants stay in the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partner Event sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Mandy Rettel, Mikhail Savitski, Frank Stein

28 November 2024

Small molecule chemistry: from proteins to pathways

Description Small molecules play an important role in biological systems They provide the precursors to macromolecules have roles in cell signalling and regulation and can be used to treat diseases To understand the role of small molecules we can study their binding interactions with macromolecular targets such as nucleic acids and proteins and the functional impact on the target and biological pathways This six hour virtual workshop will provide participants with an opportunity to gain hands on experience of using EMBL EBI tools and resources to assess the impact of drugs on their protein target and place these interactions within the context of biological pathways During this course we ll explore the biological effects of small molecules using a therapeutic drug as an example We ll consider a workflow that investigates drug binding to a protein target and the downstream pathway effects EMBL EBI tools and resources will be used to identify small molecule drugs evaluate protein binding and investigate pathway effects...

Juanita Riveros

27 November 2024

Navigating patent data with SureChEMBL

Description Patents are legal documents that grant inventors exclusive rights for a limited time in return for publicly disclosing their innovations In the pharmaceutical industry thousands of patents are published annually making information about new drug candidates and potential applications available to the public Hosted at EMBL EBI SureChEMBL provides access to over 160 million patents annotated to highlight chemical and biomedical entities With a suite of tools designed for exploring patent literature SureChEMBL serves as a valuable resource for scientific data in drug discovery This webinar will introduce the SureChEMBL web interface and demonstrate efficient ways to navigate patent data...

20 November 2024

Investigating gene function and human disease through data on the IMPC portal

Description The International Mouse Phenotyping Consortium IMPC is a resource created by an international collaborative effort from 21 research institutions aiming to identify the function of every mammalian protein coding gene using the mouse as a model organism Currently the IMPC has generated knockout lines for 8 901 mouse genes and studied them systematically to determine their function in different biological systems and their role in disease This webinar will offer an overview of how IMPC data is generated along with a guided tour of the website showcasing key features and available data We will also explore how phenotype data can be used to investigate Mendelian diseases and how the PhenoDigm algorithm can be applied to identify new models of human disease gene associations...

19 November - 22 November 2024

Quantitative biology to molecular mechanisms

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Late onsite registration is still available Please reach out to events embl org to request it This conference will take place at EMBL Heidelberg with the option to attend virtually and is being organised by EMBL with generous support from the Bayer Foundation Conference overview Recent decades have witnessed a profound transformation in molecular biology research fueled by revolutionary technologies that have greatly enhanced our ability to systematically and quantitatively measure biological molecules The use of genomics proteomics and imaging have become routine generating vast amounts of high resolution data that characterise biological systems across multiple scales ranging from molecules to organisms This technological leap allows us to describe biological systems in quantitative terms with unprecedented resolution and provides a solid foundation for formulating mechanistic models that elucidate the intricacies of biological functions Quantitative biology to molecular mechanisms formerly From functional genomics to systems biology aims to bridge the gap between technologies and scales serving as a platform for the emergence of ideas and concepts to model complex biological systems Leaders in genomics functional proteomics quantitative imaging microscopy and theory will gather to discuss their data and models transcending their respective fields of expertise The meeting will be bridging three interconnected themes where systems level approaches in molecular biology research are transforming our understanding of biological systems A large fraction of the talks 20 will be selected from abstracts with a priority for early stage researchers Session topics Systems to function Systems to molecular mechanisms Systems to disease Speakers Speakers Lacramioara Bintu Stanford University USA Anne Claude Gingras Lunenfeld Tanenbaum Research Institute Canada Luca Giorgetti Friedrich Miescher Institute for Biomedical Research Switzerland James Hackett EMBL Rome Italy Anders Sejr Hansen MIT Biological Engineering USA Denes Hnisz Max Planck Institute for Molecular Genetics Germany Joanna Jachowicz Institute of Molecular Biotechnology Austria Hartland Jackson Lunenfeld Tanenbaum Research Institute Canada Mo Khalil Boston University USA Tineke Lenstra Netherlands Cancer Institute The Netherlands Kathryn Lilley University of Cambridge UK Fan Liu Leibniz FMP Berlin Germany Nacho Molina Institute of Genetics and Molecular and Cellular Biology France Nikolai Slavov Northeastern University USA Mikko Taipale University of Toronto Canada Chris Tape University College London Cancer Institute UK Celine Vallot Institut Curie France Alexander van Oudenaarden Hubrecht Institute The Netherlands Xiaowei Zhuang Harvard University USA Scientific organisers Lacramioara Bintu Stanford University USA Hartland Jackson Lunenfeld Tanenbaum Research Institute Canada Arnaud Krebs EMBL Heidelberg Germany Tineke Lenstra Netherlands Cancer Institute Netherlands Mikhail Savitski EMBL Heidelberg Germany Conference organiser Inna B sselmann EMBL Heidelberg Germany Programme Are you on social media Post using EMBLOmics and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 19 November Time Europe Berlin Session12 00 13 30Registration and light refreshments13 30 13 45Opening remarks by Scientific Organisers13 45 17 45Systems to function Segment 1Chairs Mikhail Savitski EMBL Heidelberg GermanyArnaud Krebs EMBL Heidelberg Germany13 45 14 15Dynamics and mechanisms of bifunctional transcriptional effectors in human cellsLacramioara Bintu Stanford University USA14 15 14 30Interspecies interactions between the nematode Pristionchus pacificus and bacterial food sources reveal candidate pathways regulating gene expression behaviour and survivalMarina Athanasouli Max Planck Institute for Biology T bingen Germany14 30 14 45The genetic architecture of the human SH3 domain interaction networkSebastian Jaaks Kraatz Friedrich Miescher Institute for Biomedical Research Switzerland14 45 15 15Programming the epigenome to dissect context dependent chromatin functionJames Hackett EMBL Rome Italy15 15 15 30Widespread position dependent transcriptional regulatory sequences in plantsYoav Voichek Gregor Mendel Institute GMI Austrian Academy of Sciences Vienna BioCenter VBC Austria15 30 15 45Widespread chromatin context dependencies of DNA double strand break repair proteinsXabier Vergara Netherlands Cancer Institute The Netherlands15 45 16 15Coffee break and meet the speakers16 15 16 45Protein mis localization in human diseaseMikko Taipale University of Toronto Canada16 45 17 00Spatial reconstruction of single cell enhancer activity in a developing embryoYad Ghavi Helm Ecole Normale Sup rieure of Lyon Institute of Functional Genomics of Lyon IGFL FranceNot available on demand17 00 17 30Interrogation of subcellular processes through RNA and protein interactionKathryn Lilley University of Cambridge UKvirtual speaker17 30 17 45Mapping Genotype to Phenotype Landscapes in Human CellsAbdelghani Mazouzi Netherlands Cancer Institute The NetherlandsNot available on demand17 45 18 45Panel discussion Bridging fields in career and scienceModerator Lacramioara Bintu Stanford University USAPanel speakers Mo Khalil Boston University USAKathryn Lilley University of Cambridge UKMikko Taipale University of Toronto CanadaAlexander van Oudenaarden Hubrecht Institute The NetherlandsXiaowei Zhuang tbc Harvard University USA18 45 20 15Dinner in EMBL Canteen20 15 21 15EMBL Pub Quiz20 15 22 00After dinner drinks in ATC Rooftop lounge Day 2 Wednesday 20 November Time Europe Berlin Session09 00 12 30Systems to function Segment 2Chairs Mikko Taipale University of Toronto CanadaYad Ghavi Helm Ecole Normale Sup rieure of Lyon Institute of Functional Genomics of Lyon IGFL France09 00 09 30Novel sequencing tools to explore translation in individual cellsAlexander Van Oudenaarden Hubrecht Institute The Netherlands09 30 09 45A parsimonious mechanism to generate rhythmic gene expression with wide peak phase dispersionHelge Grosshans Friedrich Miescher Institute for Biomedical Research SwitzerlandNot available on demand09 45 10 00Developmental gene expression patterns driven by synthetic gene regulatory domainsDaniel Murad Ibrahim Berlin Institute of Health Max Planck Institute for Molecular Genetics Germany10 00 10 30Coffee break and meet the speakers10 30 11 00Building structural and spatial interactomes by cross linking mass spectrometryFan Liu Leibniz Institute FMP Berlin Germany11 00 11 30Synthetic reconstitution of complex cellular behaviorMo Khalil Boston University USANot available on demand11 30 11 45A genetic interaction map for a human cell lineMaximilian Billmann University of Bonn University Hospital Bonn GermanyNot available on demand11 45 12 00SPIDR a multiplexed method for mapping RNA Protein interactions reveals a mechanism of translational suppression in cellular stressMarko Jovanovic Columbia University USA12 00 12 30Transcription factor exchange enables prolonged transcriptional burstsTineke Lenstra Netherlands Cancer Institute The NetherlandsEMBO Young Investigator Lecture12 30 13 15Hike in the woods12 30 14 00Lunch14 00 16 00Systems to molecular mechanism Segment 1Chairs Arnaud Krebs EMBL Heidelberg GermanyMarko Jovanovic Columbia University USA14 00 14 30Discovering quantitative rules of enhancer promoter communication with large numbers of artificial regulatory landscapesLuca Giorgetti FMI Basel Switzerland14 30 14 45A phage protein kinase subverts bacterial defense systems through promiscuous phosphorylationTara Bartolec EMBL Heidelberg Germany14 45 15 00Probing DNA damage sites in living cells reveals novel DNA damage response factorsRichard Cardoso da Silva Utrecht University The NetherlandsNot available on demand15 00 15 15Functional maps of a genomic locus reveal confinement of an enhancer by its target geneChristine Moene Netherlands Cancer Institute Oncode Institute The Netherlands15 15 15 30Mechano transduction via membrane potential for growth controlMarkus Basan Harvard Medical School USA15 30 16 00Friend or foe exploring the regulatory role of transposons in early mammalian developmentJoanna Jachowicz IMBA Vienna Austria16 00 16 30Coffee break16 00 18 00Poster Session 1 odd numbers 18 00 19 30Dinner in EMBL Canteen19 30 21 00After dinner drinks in ATC Rooftop lounge Day 3 Thursday 21 November Time Europe Berlin Session09 00 12 45Systems to molecular mechanism Segment 2Chairs Lacramioara Bintu Stanford University USACeline Vallot Institut Curie France09 00 09 30Spatially resolved single cell genomics cell atlas of the brainXiaowei Zhuang Harvard University USANot available on demand09 30 09 45Mammalian promoters are characterised by low frequency of occupancy and high turnover of RNA polymerase IIKasit Chatsirisupachai EMBL Heidelberg Germany09 45 10 00Chromatin dependent motif syntax defines differentiation trajectoriesSevi Durdu Friedrich Miescher Institute for Biomedical Research Germany10 00 10 30Dynamics of microcompartment formation at the mitosis to G1 transitionAnders Sejr Hansen MIT Biological Engineering USA10 30 11 00Coffee break and meet the speakers11 00 11 30Parsing human pancreatic cancers to identify localized tumour stroma and immune environmentsHartland Jackson Lunenfeld Tanenbaum Research Institute CanadaNot available on demand11 30 11 45Scaling laws of human transcriptional activityJiayin Hong University of Cambridge United Kingdom11 45 12 00Single molecule chromatin configurations link transcription factor binding to expression in human cellsJulia Schaepe Stanford University USA12 00 12 30Using proximity dependent biotinylation to understand dynamic cell organization Anne Claude Gingras University of Toronto Canada12 30 14 15Lunch14 15 17 45Systems to disease Segment 1Chairs Tineke Lenstra Netherlands Cancer Institute The NetherlandsAnders Sejr Hansen MIT Biological Engineering USA14 15 14 45Single cell phenoscaping of tumour microenvironment organoidsChris Tape University College London UK14 45 15 00Network based framework for studying etiology and phenotype diversity in ciliopathiesEllen Aarts ETH Zurich Switzerland15 00 15 15Quantitative analysis of developmental timing in whole embryosMichael Dorrity EMBL Heidelberg Germany15 15 15 45Breast cancer epigenomics at single cell resolutionCeline Vallot Institut Curie France15 45 16 15Coffee break and meet the speakers16 15 18 15Poster session 2 even numbers 18 15 20 15Conference dinner in EMBL Canteen20 15 23 45Conference party with DJ in Foyer Day 4 Friday 22 November Time Europe Berlin Session09 30 12 15Systems to disease Segment 2Chairs Hartland Jackson Lunenfeld Tanenbaum Research Institute CanadaMikhail Savitski EMBL Heidelberg Germany09 30 10 00Transcriptional condensates in health and diseaseDenes Hnisz MPI Molecular Genetics Germany10 00 10 15Following transcription complex assembly over timeNils Eickhoff Netherlands Cancer Institute The Netherlands10 15 10 30Automated live cell single molecule imaging reveals the molecular dynamics of Sox9 during differentiation and a proliferative state transition in intestinal organoidsNike Walther University of California Berkeley USANot available on demand10 30 11 00Coffee break and meet the speakers11 00 11 30Unraveling spatio temporal regulation of gene expression during the cell cycle through integration of single cell data and biophysics informed deep learningNacho Molina Institute of Genetics and Molecular and Cellular Biology IGBMC France11 30 12 00From proteome variation across single cells to molecular mechanismsNicolai Slavov Northeastern University USA12 00 12 15Poster prize and closing remarks12 15 13 00Packed lunch and departure13 00Conference shuttle to the Main station and hotelsBus to Frankfurt am Main airport Terminal 1 tickets are available at the registration desk Practical information Registration fees and abstract submission Registration On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses On site Academia 550On site PhD Student 350On site Industry 750On site EMBL staff press 300Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Virtual registration fees include access to all of the talks live streamed and on demand and facility to submit questions NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Inna B sselmann for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only registered participants attending the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After you have logged in and successfully registered you will receive an email asking you to submit your abstract Click on the link provided and enter your abstract in the text box provided Alternatively you can submit your abstract by clicking on the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest of the title should be in lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory details are First Name Last Name Organisation Name Affiliation or Company Country and Email Mark only one author as the role of First author and please don t forget to indicate who will be presenting The order of the authors will be listed as follows First Author Co First Author alphabetically if multiple co author s in the order added by the submitter Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline Please check our FAQs pages for further information on how to submit an abstract Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events in Heidelberg and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO practical courses and workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a baby sitter or child care facility travel costs for a care giver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 18 October 2024 in some cases at special rates Please quote the booking code OMX24 01 and confirm the exact price of the room with the hotel directly Hotel AnlageHotel ibis HeidelbergHotel MonptiHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreHilton HeidelbergExzellenz Hotel Meininger Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Download the conference bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage opposite Main Train Station Premier Inn Hotel Kurf rsten Anlage 23 Leonardo Hotel City Centre Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop near Rohrbacher Str 22 ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions EnglishGermanHelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie geht s I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDanke sch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event sponsor Bronze sponsor Media partners International Union of Biochemistry and Molecular Biology Molecular Systems Biology an EMBO Press Journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 729 90...

Lacramioara Bintu, Hartland Jackson, Arnaud Krebs, Tineke Lenstra, Mikhail Savitski

18 November - 22 November 2024

Plant genomes: from data to discovery

Description This course will take you through a selection of genomic tools and open resources to help you explore plant genomes and answer biological questions Covering a range of omics data including genomic proteomic and imaging data this course will show you where to find relevant data and how to use publicly available tools to connect across resources supporting plant genomic data driven knowledge discovery Throughout the course you will address essential questions such as How can genomic data inform crop breeding strategies Which genetic variations contribute to plant resilience in changing environments How can proteomics enhance agricultural productivity The course instructors will guide you on how to navigate the different resources efficiently You will be shown how to submit your sequence to a public archive explore gene related information and variants within specific genes You will investigate functional conservation and expression patterns within gene families explore protein functional information as well as plant derived metabolomics and lipidomics data and analyse gene expression data Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Computational practicals will run using online tools meaning participants will not require access to a powerful computer or install complex software on their own machines In the week before the course there will be a brief induction session Participants will need to be available between the hours of 09 00 17 00 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Barbara Etzi

18 November - 22 November 2024

Genome bioinformatics: from short- to long-read sequencing

Description A guide to the technology analysis workflows tools and resources for next generation sequencing data analysis This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data The main focus will be on introducing sequence informatics re sequencing differences between short and long read sequencing and variant calling during the analysis of higher eukaryotes with an emphasis on human genetic research Throughout the week more advanced topics will introduce genome graphs pangenomics the creation of pipelines automation and the scaling up of analysis experiments Practical sessions will be run on datasets prepared by the trainers not on personal research data Participants will learn how to process these training datasets and to apply appropriate statistical methods in their analyses They will also learn the basics to create their own pipelines and use pipelines openly available...

Meredith Willmott

17 November - 24 November 2024

Integrative structural biology: solving molecular puzzles

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Integrative structural biology has become a key strategy for determining the structure of biological macromolecules and their complexes This method entails characterising the 3D structure through an array of complementary techniques subsequently combining the data to form a consensus model using computational methodologies This practical course offers a hands on introduction to integrative structural biology Participants will delve into the fundamentals of various experimental structure determination techniques including X ray crystallography cryo EM small angle X ray scattering NMR and mass spectrometry through both lectures and practical exercises Experts in the field will guide participants on how to analyse and interpret experimental data and construct structural models across different resolution scales A significant aspect of the course includes exploring how integrative structural biology addresses limitations of Artificial Intelligence based structure prediction methods in modelling large complexes and their functional conformations It will also highlight the emerging field of integrative structural biology of biomolecular complexes visualised directly in their cellular context The course location at the European Molecular Biology Laboratory in Hamburg and the Center for Structural Systems Biology on the DESY campus will provide on site synchrotron SAXS and MX beamlines for training A guided visit to the European XFEL site is also included in the programme Audience Participants in the early stage of their research careers Ph D students and early postdocs will be given preference based on their motivation letter Preference will also be given to applicants who i are entering the field of integrative structural biology ii plan to integrate multiple structural techniques within their own projects or plan to develop integrative modeling methods iii work on projects that will clearly benefit from an integrative approach Modules resources Introduction to the course Collecting the pieces Putting the pieces together using electron microscopy Putting the pieces together using SAXS Integrative structural dynamics Stitching the pieces together Greater than the sum of parts integrative modeling Learning outcomes This edition will train the participants to explore innovative strategies and techniques in integrative structural biology to overcome these limitations this course equips a new generation of interdisciplinary structural biologists with the necessary skills to push the boundaries of the field Through lectures practical sessions and collaborative interactions participants gain insights into the latest advancements and develop a holistic understanding of integrating diverse structural biology techniques Speakers Speakers trainers and staff Mohammed AlQuraishi Columbia University USA Isabel Bento EMBL Hamburg Germany Alexandre Bonvin Utrecht University The Netherlands Tom Burnley Science and Technology Facilities Council UK Melissa Graewert EMBL Hamburg Germany Cy Jeffries EMBL Hamburg Germany Maarten Joosten Delft University of Technology The Netherlands Agnel Joseph Science and Technology Facilities Council UK Ezgi Karaca Izmir Biomedicine and Genome Center IBG Turkey Syma Khalid University of Oxford UK Fan Liu FMP Berlin Germany Karen Manalastas Cantos Leibniz Institute of Virology Germany Dimitry Molodenskiy EMBL Hamburg Germany Tom Mulvaney Leibniz Institute of Virology Germany Agnieszka Obarska Kosinska MPI for Biophysics Frankfurt Germany Riccardo Pellarin Microbiologie mol culaire et biochimie structurale MMSB UMR 5086 CNRS France Gaia Pigino Human Technopole Italy Rina Rosenzweig Weizmann Institute Israel Thomas Schneider EMBL Hamburg Germany Giulia Zanetti UCL Birkbeck Crick UK Scientific organisers Arjen Jakobi Kavli Institute of Nanoscience The Netherlands Jan Kosinski EMBL Hamburg Germany Maya Topf CSSB LIV UKE Germany Course organisers Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOStructBio and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 17 November 2024 Time Europe Berlin Speaker18 00Arrival to the hotels Day 2 18 November 2024 Time Europe Berlin Speaker08 15 09 15Registration09 15 10 00Welcome IntroductionsJan Kosinski EMBL Hamburg GermanyArjen Jakobi Kavli Institute of Nanoscience The NetherlandsMaya Topf CSSB LIV UKE Germany10 00 11 00Lecture Integrative structure determinationJan Kosinski EMBL Hamburg Germany11 00 11 30Coffee Break11 30 12 30Lecture Integrative in cell structural biology of cilia and IFT biologyGaia Pigino Human Technopole Italy12 30 14 00Lunch14 00 17 00eXFEL team Excursion to the European XFEL17 00 19 00Student Talks19 00 22 00Dinner and Discussion Day 3 19 November 2024 Time Europe Berlin Speaker08 55 09 00Overview of the dayJan Kosinski EMBL Hamburg Germany09 00 10 00Lecture Introduction to X ray crystallographyThomas Schneider EMBL Hamburg Germany10 00 10 15Coffee Break10 15 11 15Lecture Protein structure predictionMohammed AlQuraishi Columbia University USA11 15 11 30Short break and meet the speakers12 00 13 00Lunch13 00 16 00Practical SessionPratical A X ray crystallography demoIsabel Bento EMBL Hamburg GermanyThomas Schneider EMBL Hamburg GermanyPratical B Modeling with AlphaFoldAgnieszka Obarska Kosinska MPI for Biophysics Frankfurt GermanyDmitry Molodenskiy EMBL Hamburg Germany16 00 16 15Coffee Break16 15 19 15Practical SessionPractical B Modeling with AlphaFoldAgnieszka Obarska Kosinska MPI for Biophysics Frankfurt GermanyDmitry Molodenskiy EMBL Hamburg GermanyPractical A X ray crystallography demoIsabel Bento EMBL Hamburg GermanyGleb Bourenkov EMBL Hamburg19 15 20 30Dinner and Discussion20 30 22 00Student Talks Day 4 20 November 2024 Time Europe Berlin Speaker08 55 09 00Overview of the dayArjen Jakobi Kavli Institute of Nanoscience The Netherlands09 00 10 00Lecture Introduction to Electron MicroscopyGiulia Zanetti UCL Birkbeck Crick UK10 00 11 00Lecture Fitting to EM mapsMaya Topf CSSB LIV UKE Germany11 00 11 30Coffee Break11 30 12 30Lecture Model refinement to X ray and EM dataArjen Jakobi Kavli Institute of Nanoscience The Netherlands12 30 14 00Lunch Career Session14 00 14 30Lecture Model validationAgnel Joseph Science and Technology Facilities Council UK14 30 17 00Practical Session C Rigid and flexible fitting into cryoEM mapsMaya Topf CSSB LIV UKE GermanyGuendalina Marini UKE GermanyTom Mulvaney Leibniz Institute of Virology GermanyAgnel Joseph Science and Technology Facilities Council UK17 00 17 15Coffee Break17 15 19 45Practical Session D High resolution model refinementArjen Jakobi Kavli Institute of Nanoscience The NetherlandsTom Burnley Science and Technology Facilities Council UKAgnel Joseph Science and Technology Facilities Council UKMaarten Joosten Delft University of Technology The Netherlands19 45 22 00Dinner and Discussion Day 5 21 November 2024 Time Europe Berlin Speakers08 55 09 00Overview of the dayMaya Topf CSSB LIV UKE Germany09 00 10 00Lecture Introduction to SAXSMelissa Graewert EMBL Hamburg Germany10 00 11 00Lecture Modeling based on SAXSCy Jeffries EMBL Hamburg Germany11 00 11 30Coffee Break11 30 12 15Practical SessionPractical E SAXS measurementsCy Jeffries EMBL Hamburg GermanyAleksi Sutinen MBL Hamburg GermanyPractical F SAXS data analysisMelissa Graewert EMBL HamburgDmitry Molodenskiy EMBL Hamburg Germany12 15 13 00Practical SessionPractical F SAXS data analysisMelissa Graewert EMBL HamburgDmitry Molodenskiy EMBL Hamburg GermanyPractical E SAXS measurementsCy Jeffries EMBL Hamburg GermanyAleksi Sutinen MBL Hamburg GermanyAleksi Sutinen MBL Hamburg Germany13 00 14 30Lunch14 30 18 00Practical Session G Integrative modelling using SAXS dataMelissa Graewert EMBL Hamburg GermanyDmitry Molodenskiy EMBL Hamburg Germany18 00 22 00Poster Session with drinks and pizza dinner Day 6 22 November 2024 Time Europe Berlin Speaker08 55 09 00Overview of the dayArjen Jakobi Kavli Institute of Nanoscience The Netherlands09 00 10 00Lecture Molecular dynamics simulationsSyma Khalid University of Oxford UK10 00 11 00Lecture Structure determination of large complexes using NMR and cryo EMRina Rosenzweig Weizmann Institute Israel11 00 11 30Coffee Break11 30 12 30CSSB EM facility tour and imaging show and tell by CryoEM facility staff12 30 14 00Lunch14 00 17 00Social event Tour to HafenCity and a harbor boat trip optional or Free afternoon optional discussions with tutors Day 7 23 November 2024 Time Europe Berlin Speaker08 55 09 00Overview of the dayMaya Topf CSSB LIV UKE Germany09 00 10 00Lecture Mass spectrometry techniques in structural and cell biologyFan Liu FMP Berlin Germany10 00 11 00Lecture Crosslink guided modelingRiccardo Pellarin Microbiologie mol culaire et biochimie structurale France11 00 11 30Coffee Break11 30 12 30Lecture Integrative modeling with HaddockAlexandre Bonvin Utrecht University The Netherlands12 30 14 00Lunch14 00 16 00Practical Session H Integrative modeling with HADDOCK part 1Ezgi Karaca Izmir Biomedicine and Genome Center TurkeyAlexandre Bonvin Utrecht University The NetherlandsDmitry Molodenskiy EMBL Hamburg Germany16 00 16 30Coffee Break16 30 19 30Practical Session H Integrative modeling with HADDOCK part 2Ezgi Karaca Izmir Biomedicine and Genome Center TurkeyAlexandre Bonvin Utrecht University The NetherlandsDmitry Molodenskiy EMBL Hamburg Germany19 30 21 00Dinner and Discussion Day 8 24 November 2024 Time Europe Berlin Speaker08 55 09 00Overview of the dayJan Kosinski EMBL Hamburg Germany09 00 10 30Practical Session I AI powered integrative modeling part 1 using Assembline RoseTTAFold AlphaLink XLMS tools and TEMPy ReFF Jan Kosinski EMBL Hamburg GermanyMaya Topf CSSB LIV UKE GermanyDmitry Molodenskiy EMBL Hamburg GermanyAgnieszka Obarska Kosinska MPI for Biophysics Frankfurt GermanyRiccardo Pellarin Microbiologie mol culaire et biochimie structurale FranceKaren Manalastas Cantos Leibniz Institute of Virology GermanyThomas Mulvaney Leibniz Institute of Virology Germany10 30 11 00Coffee Break11 00 12 00Practical Session I AI powered integrative modeling part 2 using Assembline RoseTTAFold AlphaLink XLMS tools and TEMPy ReFF Jan Kosinski EMBL Hamburg GermanyMaya Topf CSSB LIV UKE GermanyDmitry Molodenskiy EMBL Hamburg GermanyAgnieszka Obarska Kosinska MPI for Biophysics Frankfurt GermanyRiccardo Pellarin Microbiologie mol culaire et biochimie structurale FranceKaren Manalastas Cantos Leibniz Institute of Virology GermanyThomas Mulvaney Leibniz Institute of Virology Germany12 00 13 30Lunch13 30 16 00Practical Session I AI powered integrative modeling part 3 using Assembline RoseTTAFold AlphaLink XLMS tools and TEMPy ReFF Jan Kosinski EMBL Hamburg GermanyMaya Topf CSSB LIV UKE GermanyDmitry Molodenskiy EMBL Hamburg GermanyAgnieszka Obarska Kosinska MPI for Biophysics Frankfurt GermanyRiccardo Pellarin Microbiologie mol culaire et biochimie structurale FranceKaren Manalastas Cantos Leibniz Institute of Virology GermanyThomas Mulvaney Leibniz Institute of Virology Germany16 00 17 00Summary Round Table including discussion onresponsible conduct of research17 00 19 00Break free time19 00 22 00Dinner and Discussion Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the DESY Guest House to the venue Academia 250PhD Student 250Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and transport Reservations for single room accommodation at the DESY hostel have been made Note accommodation is included in the registration fee The guest house is within a few minutes walk from the EMBL laboratories and P12 beamline Further information Address EMBL Hamburg Notkestra e 85 Buliding 48e 22607 Hamburg GermanyFrom Hamburg airport take line S1 to Othmarschen 18 stops 45 min change to bus number 1 towards Rissen or Schenefelder Holt to Zum H nengrab DESY 5 stops 10 min From Hamburg Altona train station take bus number 1 to Zum H nengrab DESY 15 stops 25 min Ticket costs Public Transport ca 3 60 and a taxi will be around 45 Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course A laptop with preinstalled software will be provided to each participant Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Arjen Jakobi, Jan Kosinski, Maya Topf

17 November - 22 November 2024

Humanized mice: immunotherapy and regenerative medicine

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Humanized mouse models became an integral part of basic and translational biomedical research for the understanding of human pathologies and for development of new therapies Human cells or tissues implanted in mice can reflect human hematopoiesis immunity oncology infections physiology and genetic polymorphisms The development of immunotherapeutic drugs cell and tissue therapies rely on the preclinical testing to assess their potency and safety Big pharma and biotech companies include humanized mice in the non clinical development portfolio Humanized mouse models have varied among laboratories regarding the use of new transgenic and knock out strains improved handling methods innovative sources and manipulation techniques of the human graft material and novel technological platforms for analyses The topics of this course are immune reconstitution oncology immuno oncology regenerative medicine and infections We will update the participants about different case by case models starting with the basic science and how to best explore these models with accurate data acquisition and reporting We aim to instruct the principles of experimental pre requisites for data recording and harmonized analyses within the field Techniques and results will be presented and discussed in sessions round tables will focus on ethics requirements for animal handling and human tissue collections Social activities will boost networking among international participants Audience This course is aimed at PhD students and early post doctoral researchers who are entering the field of humanized mice models Modules Human hematopoiesis and immunity in mice Human tumour models Human immuno oncology in vivo from basics to applications Regenerative medicine gene therapy gene editing induced pluripotent stem cells and the liver Infections What past participants say about the course The course was a great professional investment and a unique opportunity to make new contacts learn from experts be inspired and learn a lot I highly recommend this course Priscila Pini Zenatti Boldrini Children Hospital Brazil The course on humanised mice gave me the opportunity to meet and connect with young and established researchers in the field Not only could I gain valuable feedback on my work as well as the humanised mouse model but also connect with the research community and strengthen my skills Lisa Rieble University of Z rich Switzerland This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Speakers trainers and staff Marta Alonso Rold n Cl nica and CIMA Universidad de Navarra Spain Jamal Alzubi University of Freiburg Germany Daniel Bachurski University Hospital Cologne Germany Karl Dimiter Bissig Duke University School of Medicine USA Michael Brehm UMass Chan Medical School USA Milita Darguzyte University Hospital Cologne Germany Ernesto de la Cueva Bueno EMBL Heidelberg Germany James DiSanto Institut Pasteur France Ashley Gardner The Jackson Laboratory USA Daniel Gimenes EMBL Heidelberg Germany Kristina Howard Food and Drug Administration USA Virtual speaker James Keck The Jackson Laboratory USA Zander Kostka Newman University of Colorado Anschutz Medical Campus USA Julie Lang University of Colorado Anschutz Medical Campus USA Christian M nz University of Zurich Switzerland Roberta Pelanda University of Colorado Anschutz Medical Campus USA Sandra Petrus University of Cambridge United Kingdom Virtual speaker Alessandra Piersigilli Takeda Pharmaceutical Company Limited USA Lisa Rieble University of Zurich Switzerland Estefan a Rodr guez Bernhard Nocht Institute for Tropical Medicine Germany Ali Roghanian University of Southampton United Kingdom Maria Silvia Roman Azcona University Medical Center Freiburg Germany Johannes Sam Roche Innovation Center Zurich Switzerland Jan Jacob Schuringa University of Groningen The Netherlands Leonard Shultz The Jackson Laboratory USA Brian Soper The Jackson Laboratory USA Renata Stripecke University Hospital Cologne Germany Natascha Stumpf University Hospital Cologne Germany Bruce Torbett University of Washington USA Bart Vandekerckhove Ghent University Belgium Li Chin Yao The Jackson Laboratory USA Chun Yu The Jackson Laboratory USA Scientific organisers Christian M nz University of Zurich Switzerland Estefan a Rodr guez Bernhard Nocht Institute for Tropical Medicine Germany Jan Jacob Schuringa University of Groningen The Netherlands Leonard Shultz The Jackson Laboratory USA Brian Soper The Jackson Laboratory USA Renata Stripecke University Hospital Cologne Germany Course organisers Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBOHuMice and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings and protocol reading with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 17 November 2024 Time Europe Berlin SessionLocation11 45 12 00Bus from hotel to EMBL ATC EntranceISG Hotel12 00 13 00Arrival registrations with light lunchFlex Lab A B13 00 13 30Welcome introductionsFlex Lab A B13 30 15 00Flash TalksFlex Lab A B15 00 16 00Humanized mice past present and future and Q ALeonard Shultz The Jackson Laboratory USAFlex Lab A B16 00 16 30Bus to city centreATC Entrance16 30 18 00Guided tourHeidelberg City Centre18 00 19 00Free timeHeidelberg City Centre19 00Bus to hotel and dinnerISG Hotel Day 2 Monday 18 November 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the dayFlex Lab A B09 00 09 45Lecture Multi lineage human immune system development by PBMC engraftmentMichael Brehm UMass Chan Medical School USAJames Keck The Jackson Laboratory USAFlex Lab A B09 45 10 30Lecture HSC humanized mouse models and reconstitution of human innate cells and lymphatic tissuesJames DiSanto Pasteur Institute FranceFlex Lab A B10 30 11 00Coffee breakFlex Lab A B11 00 11 45Lecture Models to study human unconventional T cellsBart Vandekerckhove University of Ghent BelgiumFlex Lab A B11 45 12 30Lecture Human B cell development and tolerance in humanized miceRoberta Pelanda University of Colorado USAFlex Lab A B12 30 13 30LunchEMBL Canteen13 30 13 45Live Q A to pre recorded practical introduction Refresher course mouse handling and tissue collectionsErnesto de la Cueva EMBL Heidelberg GermanyFlex Lab A B13 45 14 00Live Q A to pre recorded practical introduction Refresher course flow cytometry analysesDaniel Gimenes EMBL Heidelberg GermanyFlex Lab A B14 00 14 15Live Q A to pre recorded practical introduction and protocolStandardization of multicolor flow cytometry panels staining techniques and minimal information for standardizationsAshley Gardner The Jackson Laboratory USAFlex Lab A B14 15 18 15Practical 1 Animal handling Immune Reconstitution Flow CytometryGroups 1 and 2 BloodGroup 3 and 4 SpleenGroup 5 and 6 Bone MarrowTrainers Ashley Gardner and Lisa RiebleHelpers Milita Darguzyte Daniel Gimenes Julie Lang Estefania Rodr guez Ali Roghanian Li Chin YaoTraining Lab B18 15 18 45Tapas dinnerATC Rooftop Lounge18 45 20 45Poster session 1 ODD numbers Helix B20 45 21 15Meet the speaker and round table discussionResults ARRIVE guidelines for reporting data Chairs Roberta Pelanda and Michael Brehm ATC Rooftop Lounge21 15Bus to hotelATC Entrance Day 3 Tuesday 19 November 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the dayFlex Lab A B09 00 09 45Lecture Acute leukemia models genomics and tumor microenvironmentJan Jakob Schuringa University of Groningen The NetherlandsFlex Lab A B09 45 10 30Lecture Humanized NSGF6 mice immune reconstitution and melanoma metastasisChun Yu The Jackson Laboratory USAFlex Lab A B10 30 11 00Coffee breakFlex Lab A B11 00 11 45Lecture PDX Models of Glioblastoma and oncolytic viral therapiesMarta Alonso University of Navarra SpainFlex Lab A B11 45 12 30Lecture Defining tumors for pharmacologic developmentsAlessandra Piersigilli Takeda USAFlex Lab A B12 30 13 30LunchEMBL Canteen13 30 13 45Live Q A to pre recorded practical introduction Testing monoclonal antibodies schedules and dose finding Ali Roghanian University of Southampton United KingdomFlex Lab A B13 45 17 45Practical 2Analysis of Xenograft tumor models grown on HIS mice Principles of tumor biopsies flow cytometry analysis of humanized xenograft tumor models Trainers Julie Lang Ali Roghanian and Li Chin YaoHelpers Milita Darguzyte Ashley Gardner Zander Kostka Newman Lisa Rieble Estefania Rodr guezTraining Lab B17 45 18 15Vegetarian pizza dinnerATC Rooftop Lounge18 15 20 15Poster session 2 EVEN numbers 5 minutes presentation and 5 minutes questions per person 2 h max Helix B20 15 20 45Meet the speaker and round table discussionEthics for obtaning human material Chairs Marta Alonso and Jan Jakob Schuringa Flex Lab A B20 45Bus to hotelATC Entrance Day 4 Wednesday 20 November 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the dayFlex Lab A B09 00 09 45Lecture Applications of Humanized Platforms in Immuno OncologyBrian Soper The Jackson Laboratory USAFlex Lab A B09 45 10 30Lecture Studies of the tumor microenvironment and correlates of immune responses in immune oncology HIS mice modelsJulie Lang University of Colorado Anschutz Medical Center USAFlex Lab A B10 30 11 15Coffee break and group photoTBC11 15 12 00Lecture Application of humanized mouse models in drug discoveryJohannes Sam Roche Z rich SwitzerlandFlex Lab A B12 00 12 45Lecture Neonatal tissue based models for biosimilar research CRS Virtual Kristina Howard Center for Drug Evaluation and Research USAFlex Lab A B12 45 13 45LunchEMBL Canteen13 45 14 00Live Q A to pre recorded practical introduction Advanced histopathology Analytical t SNE t distributed Stochastic Neighbor Embedding immune cell imaging in the tumor environment location organization interaction quantitation Daniel Bachurski University Hospital Cologne GermanyFlex Lab A B14 00 14 15Live Q A to pre recorded practical introduction Implantation collection and processing of tumorsLi Chin Yao The Jackson Laboratory USAFlex Lab A B14 15 18 15Practical session 3 Combined sessions 1 IHC of humanized xenograft tumor models and 2 injection routes of humanization 3 tumor biopsies and implantationTrainers Daniel Bachurski Estefania Rodr guez Li Chin YaoHelpers Milita Darguzyte Julie Lang Zander Kostka NewmanTraining Lab B18 15 19 15DinnerEMBL Canteen19 15 20 15Meet the speaker and round tableLymph Nodes in humanized mice Chairs Julie Lang and Brian Soper Flex Lab A B20 15Bus to hotelATC Entrance Day 5 Thursday 21 November 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the dayFlex Lab A B09 00 09 45Lecture Regenerative Medicine Gene modification of hematopoietic cells with lentiviral vectors and gene editing against cancer and pathologiesRenata Stripecke University Hospital of Cologne GermanyFlex Lab A B09 45 10 30Lecture Gene Editing of hematopoietic stem cells and T cells for clinical usesMaria Silvia Roman Azcona University Medical Center Freiburg GermanyFlex Lab A B10 30 11 00Coffee breakFlex Lab A B11 00 11 15Live Discussion and Q A to pre recorded lecture Development of human organoids and use in humanized mouse models Virtual Sandra Petrus University of Cambridge UKFlex Lab A B11 15 12 00Lecture Human liver chimeric mouse models the chances challengesKarl Dimiter Bissig Duke University Medical Center USAFlex Lab A B12 00 12 15Live Q A to pre recorded practical introduction Gene editing molecular tools and methodsJamal Alzubi University of Freiburg GermanyFlex Lab A B12 15 12 30Live Q A to pre recorded practical introduction Gene editing standard operating procedures for practical classRenata Stripecke University Hospital of Cologne GermanyFlex Lab A B12 00 13 00LunchEMBL Canteen13 00 17 00Practical 4 Engineering the grafts via non viral CRISPR Cas gene editing knock outs and knock insGroup 1 Gene editing hematopoietic stem cellsGroup 2 Gene editing T cellsGroup 3 Gene editing tumor cellsTrainers Jamal Azubi Milita Darguzyte Ali Roghanian Renata StripeckeHelpers Lisa Rieble Estefania Rodr guez Li Chin YaoFlex Lab A B17 00 18 00Bus to Downtown stop at ISG Hotel ATC Entrance18 00 21 00Downtown dinnerWirtshaus zum Nepomuk Day 6 Friday 22 November 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel08 55 09 00Overview of the dayFlex Lab A B09 00 09 45Lecture Infections of immunocompromised hosts EBV and KSVChristian M nz University of Z rich SwitzerlandFlex Lab A B09 45 10 30Lecture Humanized mice to study emerging viral infectionsEstefania Rodr guez Bernhard Nocht Institute for Tropical Medicine GermanyFlex Lab A B10 30 11 00Coffee breakFlex Lab A B11 00 11 45Lecture Infection of humanized mice with HIV and development of new therapiesBruce Torbett University of Washington USAFlex Lab A B11 45 12 30LunchEMBL Canteen12 30 13 30Final discussions feedback closing remarksFlex Lab A B13 30Bus to Hotel and Heidelberg train stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 16 to 21 November 6 nights In case you would like to have a single room please let the hotel know and note that you will be required to pay directly an additional cost of 24 per night availability of single rooms may be limited Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Course partners Course sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Christian Münz, Estefanía Rodríguez, Jan Jacob Schuringa, Leonard Shultz, Brian Soper, Renata Stripecke

14 November - 15 November 2024

The next generation in infection biology

Description OverviewOrganisers and speakersParticipating organisationsProgrammePractical informationSponsorsMedia kit Overview After the success of the virtual 2022 edition this conference will return in a virtual format Conference overview Infectious diseases are among the most prevalent causes of human illness and death in the world Pathogens infect humans and all life forms on Earth being able to cross species barriers thereby adversely impacting human and planetary health Fundamental research in infection biology is urgently needed to find therapies for longstanding and emerging infectious diseases The EMBL Conference The next generation in infection biology is a platform for late stage postdoctoral scientists in the field of infection biology to present their work and connect with the leading European institutions in infection biology The speakers will be chosen for their track record of research accomplishments and their high reaching future plans The audience will have the unique opportunity to experience cutting edge science presented by the rising leaders in this field The institutional partners will provide discussion and networking opportunities to connect and shape the future league of infection biologists in Europe Session topics Pathogen biology Host pathogen interfaces Host genetics and immunology Anti infectives vaccines and antimicrobials Computational methods and analyses for infection What past participants say about the conference This format was really made for postdocs seeking a professorship and it is just amazing I got to speak face to face with PIs whom I would never have had the courage to approach in a normal conference I got insightful comments for my career and I really hope this format repeats again Cl udia Vilhena Leibniz Institute for Natural Products and Infection Biology Germany The conference The next generation in infection biology was a fantastic experience It brought together young investigators at a transition point in their careers to become independent group leaders and established researchers who have shaped the field of infection biology It was a unique opportunity to share science and network and an excellent concept altogether Mariana De Niz Institute of Molecular Medicine Portugal Organisers and speakers Plenary Speakers Melanie Blokesch Global Health Institute EPFL Switzerland Freddy Frischknecht Center for Integrative Infectious Disease Research Heidelberg University Germany Scientific Organisers Maria Bernabeu EMBL Barcelona Spain Jan Kosinski EMBL Hamburg Germany Eva Kowalinski EMBL Grenoble France John Lees EMBL EBI United Kingdom Nassos Typas EMBL Heidelberg Germany Conference Organisers Sophie Dutzi EMBL Heidelberg Germany Lizette de Paula EMBL Heidelberg Germany Participating organisations Please find below a list of participating institutes and universities with more to be confirmed in the coming weeks Institutes UniversitiesCountrySpokespersonAix Marseille University CNRS Institut de Microbiologie de la M diterran e IMM FranceT m MignotBiozentrum University of BaselSwitzerlandChristoph Dehio Dirk Bumann Urs Jenal Center for Integrative Infectious Disease Research CIID Heidelberg UniversityGermanyFreddy FrischknechtCentre for Structural Systems Biology CSSB GermanyKay Gr newald Charlotte Uetrecht Holger SondermannCSIC CNB National Centre for BiotechnologySpainDaniel Lopezde Duve Institute Universit Catholique de LouvainBelgiumJean Fran ois ColletETH Zurich Institute of MicrobiologySwitzerlandWolf Dietrich HardtGlobal Health Institute EPFLSwitzerlandMelanie BlokeschGIMM Gulbenkain Institute for Molecular MedicinePortugalKarina XavierHelmholtz Centre for Infection Research HZI GermanyJosef PenningerHuman TechnopoleItalyFernanda PinheiroInstitut PasteurFranceSebastian BaumgartenAude BernheimCarmen BuchrieserInstitute of Molecular Biology and Biotechnology of the Foundation for Research and Technology Hellas IMBB FORTH GreeceGeorgios ChamilosInstitute of Technology University of TartuEstoniaTanel TensonKarolinska InstitutetSwedenMarie Stephanie AschtgenEdmund LohLondon School Hygiene Tropical MedicineUKSerge MostowyThe Francis Crick InstituteUKMaximiliano GutierrezThe Laboratory for Molecular Infection Medicine Sweden MIMS Ume UniversitySwedenOliver Billker VIBBelgiumCharles van der HenstJan MichielsWeizmann Institute of ScienceIsraelRoi Avraham Programme Are you on social media Post using EMBLInfectionBiology and don t forget to tag EMBLEvents Please note that the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Thursday 14 November 2024 Time Europe Berlin Session13 20 13 40 Opening remarks by scientific organisers13 40 14 20Plenary TalkDeciphering Defense Systems of 7th Pandemic Vibrio choleraeMelanie Blokesch Global Health Institute EPFL Switzerland14 20 14 25Session 1 Pathogen biologySession Chairs Sebastian Baumgarten Institute Pasteur FranceEva Kowalinski EMBL Grenoble France14 25 14 45Interspecies interactions modulate pathogenicity associated phenotypes of Clostridioides difficileStephan Kamrad University of Cambridge UKNot available on demand14 45 15 05Rare infection phenotypes and how to find themCamilla Ciolli Mattioli Weizmann Institute of Science Israel15 05 15 25A core network in the SARS CoV 2 Nucleocapsid NTD orchestrates RNA recognitionSophie Korn Columbia University USA15 25 15 45In cell discovery in Mycoplasma pneumoniae using CryoETRasmus Jensen EMBL Heidelberg GermanyNot available on demand15 45 16 05Break16 05 16 45Networking Session 116 45 17 00EU funding infrastructure talkJonathan Ewbank ERINHA17 00 17 05Session 2 Host pathogen InterfacesSession Chairs Maria Bernabeu EMBL Barcelona SpainWolf Dietrich Hardt ETH Zurich Institute of Microbiology Switzerland17 05 17 25The battle between host and uropathogen in a human bladder microtissue modelCarlos Flores Biozentrum University of Basel Switzerland17 25 17 45Mapping the host Shigella interface with proximity biotinylationAna Teresa Lopez Jimenez London School of Hygiene and Tropical Medicine UKNot available on demand17 45 18 05Pseudomonas aeruginosa faces fitness trade offs at the airway mucosal surfaceLucas Meirelles EPFL SwitzerlandNot available on demand18 05 18 25Viral bacterial co infections screen in vitro reveals molecular processes affecting pathogen proliferation and host cell viabilityPhilipp Walch University of Lausanne Switzerland Day 2 Friday 15 November 2024 Time Europe Berlin Session11 00 12 15Career panel discussion Preparing for an academic interview12 15 13 00Break13 00 13 10Introduction remarks13 10 13 50Plenary talkMalaria research from basic insights to vaccine studiesFreddy Frischknecht Center for Integrative Infectious Disease Research CIID Heidelberg University Germany13 50 13 55Session 3 Host pathogen Interfaces IISession Chairs Maximiliano Gutierrez The Francis Crick Institute UKJan Kosinski EMBL Hamburg Germany13 55 14 15Characterizing Host Genetics Microbiome Interactions Prior to and During the Onset of Atopic Dermatitis and Food Allergy in InfancyZeyang Shen National Human Genome Research Institute NIH USA14 15 14 35Hidden threats A new paradigm in our understanding of antigenic variation and chronic asymptomatic malaria infectionsFrancesca Florini Weill Cornell Medicine USA14 35 14 55C4b Binding Protein and Factor H attenuate NLRP3 Inflammasome mediated signalling response during Group A Streptococci infection in human cellsSerena Bettoni University of Bristol UKNot available on demand14 55 15 15Break15 15 16 00Networking Session 216 00 16 05Session 4 Anti infectives vaccines antimicrobials Session Chairs Dirk Bumann Biozentrum University of Basel SwitzerlandNassos Typas EMBL Heidelberg Germany16 05 16 25Modulation of vaccine induced immunity via the gut microbiomeKelsey Huus Max Planck Institute for Biology T bingen Germany16 25 16 45Microbial context dependence in the evolution of antibiotic resistant Klebsiella pneumoniaeMichael Knopp EMBL Heidelberg GermanyNot available on demand16 45 17 05Goblet cell invasion by Pseudomonas aeruginosa promotes breaching of human respiratory epitheliaA Leoni Swart University of Basel Switzerland17 05 17 25Break17 25 18 10Networking Session 318 10 18 15Session 5 Computational methods and analyses for infectionSession Chairs Oliver Billker The Laboratory for Molecular Infection Medicine Sweden MIMS Ume University SwedenFernanda Pinheiro Human Technopole Italy18 15 18 35A large language model for studying bacterial genome architecture population structure and epidemiologySamuel Horsfield EMBL EBI UK18 35 18 55Bayesian modeling of bottleneck effects enables organoid infection screensLaura Jenniches Helmholtz Institut f r RNA basierte Infektionsforschung Germany18 55 19 15The role of non coding RNAs in regulating gametocyte development in malaria parasitesJanne Gr nebast University of Maryland School of Medicine USA19 15 19 30Closing remarks Practical information Registration Fees and Abstract Submission Registration Fees include access to all of the talks and online group discussions and help us cover our costs to run the event For further information please refer to the FAQ page Virtual Academia 225Virtual PhD Student 175Virtual Industry 225 Accredited journalists may be eligible to register for complimentary registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Sophie Dutzi for more information Confirmation and Payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee Types of payments accepted are international bank transfers and credit card payments Abstract Submission Instructions for Postdocs wishing to apply for an oral presentation Only registered participants are eligible to submit an abstract We only accept online abstract submissions After you have logged in and successfully registered you will receive an email asking you to submit your abstract of your current work general directions of your future lab specific aims of your research plan and include a brief CV with three selected publications Additionally you will be asked to submit a 5 minutes video short talk Click on the link provided and enter your application details Alternatively you can submit your abstract by clicking on the link on the confirmation page directly after registering Your application will only be complete when both abstract and short talk video have been submitted Plenary talks will be selected from the applications based on all submitted material The submitted application material will be accessible to all participants throughout the conference A selection process will take place with the results announced 3 4 weeks after the abstract submission deadline For infection biology institutes wishing to participate please contact the organisers Financial Assistance Registration Fee Waivers All academic and student registrants are invited to apply for a registration fee waiver provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO The registration fee waiver covers the registration sum that you have paid to attend the meeting Conference participants are not required to pre pay the registration fee to be selected for a fee waiver for a virtual meeting If you have already paid the registration fee and are awarded a fee waiver it will be reimbursed after the meeting Application Applications for financial assistance can be submitted via the submission portal for the submission of abstracts for conferences or the submission of motivation letters for courses by completing the Financial Assistance Application Section underneath the section for entering abstract motivation letter information The link to the portal can be found in the registration confirmation email that you will receive after registering for the conference Selection The scientific organisers will select the recipients of registration fee waivers during the abstract selection process for conferences and the participant selection process for courses Results will be announced approximately 3 4 weeks before the event start date Selection results do not impact your admission to the meeting Registration fee waiver selection is based on your current work or study location your motivation for applying the reasons for needing financial support and the impact this event will have on your career Further details Check our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Virtual Participation Guidelines Guidelines Please do Use the event specific hashtag as communicated during the event for any related tweets Tweet unless the speaker specifically says otherwise Be mindful of unpublished data Be respectful in tone and content Please don t Share live stream or poster session links with others Broadcast the conference to unregistered participants Capture transmit or redistribute data presented at the meeting unless presenter gives explicit consent Use offensive language in your posts Engage in rudeness or personal attacks Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos You can find these under resources on the conference platform How to ask questions Please use the Q A function It is possible to send a direct message to participants poster presenters and speakers within the conference platform If you have any other questions you can go to the Help Desk on the conference platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on Central European Time CET or Central European Summer Time CEST unless otherwise stated As many virtual participants are attending from around the world we do our best to accommodate as many time zones as possible when creating the programme Please take your time zone into consideration when planning your attendance Remember to set your time zone in your account Virtual event platforms We are using a virtual event platform for this conference More information about the platform will be shared ahead of the conference Additional Information Please find additional information including FAQs and terms and conditions on our Information for Participants page Sponsors Event sponsor Event supporter Media partners ChemBioChem a Wiley Journal Cell Host and Microbe a Cell Press Journal Disease Models Mechanisms The Company of Biologists Journal EMBO Molecular Medicine an EMBO Press journal FEBS Letters International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 729 90...

Maria Bernabeu, Jan Kosinski, Eva Kowalinski, John Lees, Lizette de Paula, Nassos Typas

13 November 2024

MGnify Proteins: a new resource of 2.5 billion proteins for exploring metagenomics sequence space

Description MGnify is EMBL EBI s microbiome data resource which enables the analysis and exploration of metagenomic metatranscriptomic amplicon and assembly data This webinar will showcase the recently released MGnify Proteins website which provides information regarding the proteins identified through MGnify s analysis pipeline In MGnify Proteins the information about proteins are accompanied by metadata such as underlying biological domains and encountered environments The protein sequence data is further utilised in other MGnify resources such as MGnifams to generate protein families models and structures...

6 November 2024

A guide to Job Dispatcher sequence analysis tools and programmatic access

Description The Job Dispatcher at EMBL EBI provides free access to a variety of bioinformatics tools and biological datasets via web and programmatic interfaces This webinar will provide a comprehensive guide on navigating various sequence analysis tools EMBOSS Clustal Omega NCBI BLAST etc and showcase the newest updates to the website It will also demonstrate how to access these tools programmatically...

5 November - 8 November 2024

DNA replication: from basic biology to disease

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia Kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview There has been tremendous progress in the past few years regarding our understanding of DNA replication in eukaryotes both yeast and mammals Many important questions in the field are poised to be answered within the next decade These include understanding DNA replication at the biochemical and three dimensional protein structure levels In addition studies using high throughput technologies at the cellular and organismal levels are poised to answer how accurate replication of the genome is ensured by controlling origin firing in space and time Session topics Replisome structure Origin selection licensing and firing Chromatin replication Replication stress and fork stability Replication in cancer etiology and treatment opportunities Speakers Keynote speakers John Diffley The Francis Crick Institute UK Bik Tye Professor emeritus at Cornell University USA Speakers Naama Barkai Weizmann Institute of Science Israel Sara Buonomo The University of Edinburgh UK Karlene Cimprich Stanford University USA Alessandro Costa The Francis Crick Institute UK Vincenzo Costanzo The FIRC Institute of Molecular Oncology Italy Nynke Dekker University of Oxford UK Olivier Hyrien Institut de Biologie de l cole Normale Sup rieure France Qing Li Peking University China Massimo Lopes Institute of Molecular Cancer Research Switzerland Kyungjae Myung Ulsan National Institute of Science and Technology South Korea Jan Michael Peters Research Institute of Molecular Pathology IMP Austria Agata Smogorzewska The Rockefeller University USA Julian Stingele Gene Center and Department of Biochemistry Ludwig Maximilians Universit t M nchen Germany Nitika Taneja Erasmus University Medical Center The Netherlands Scientific organisers Anja Groth University of Copenhagen Denmark Thanos Halazonetis Universit de Gen ve Switzerland Helle Ulrich Institute of Molecular Biology GmbH Germany Conference organiser Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EESReplication and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 5 November 2024 Timings Europe CET Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarksAnja Groth13 45 17 30Session 1 Replisome structureChairs Anja Groth and Christian Speck13 45 14 45Keynote lecture Four decades of eukaryotic DNA replication from yeast genetics to cryoEM structures of the replisomeBik Tye Professor emeritus at Cornell University USA14 45 15 15Non canonical ATR signaling extends replicationfork slowing and remodelling to undamaged nuclear regions via NBS1 phosphorylationMassimo Lopes Institute of Molecular Cancer Research SwitzerlandNot available on demand15 15 15 30Multiple mechanisms for licensing human replication originsFranziska Bleichert Yale University USA15 30 15 45Principles of yeast and human DNA licensingMaximillian Reuter Imperial College London UK15 45 16 30Coffee Break and Meet the speakersBik Tye Keynote Professor emeritus at Cornell University USAMassimo Lopes Institute of Molecular Cancer Research Switzerland16 30 17 00Structural studies on the eukaryotic replisomeAlessandro Costa The Francis Crick Institute UK17 00 17 15How is the Replicative DNA Helicase Activated in Metazoa Insights from Single Molecule Studies Gheorghe Chistol Stanford University USANot available on demand17 15 17 30A molecular trigger for replication fork collapseCameron McClymont The Francis Crick Institute UK17 30 17 45DNA Replication origin usage and the 3D genomeMarcel M chali CNRS University of Montpellier FranceNot available on demand17 45 19 15 Meet the speakers dinner in the canteen Speakers allocated to each table19 15 20 45Parallel social options Pub Quiz in the Canteen19 15 22 00Parallel social options Networking drinks in the ATC rooftop lounge Day 2 Wednesday 6 November 2024 Timings Europe CET Speaker08 30 09 00Arrival and coffee09 00 12 00Session 2 Origin selection licensing and firingChairs Mirit Aladjem and Nick Rhind09 00 09 30How ORC recognises its genomic binding sitesNaama Barkai Weizmann Institute of Science Israel09 30 09 45Mapping of DNA replication origins in vivo highlights mechanisms of genome stability and agingGiacomo Rossetti University of Geneva Switzerland09 45 10 00PCNA loading during leading strand synthesis in the budding yeast replisomeEmma Fletcher MRC Laboratory of Molecular Biology UK10 00 10 30Coffee Break and Meet the speakersAlessandro Costa The Francis Crick Institute UKNaama Barkai Weizmann Institute of Science Israel10 30 11 00Nanopore sequencing studies of budding yeast and human genome replicationOlivier Hyrien Institut de Biologie de l cole Normale Sup rieure FranceNot available on demand11 00 11 15Dual DNA replication modes Varying fork speeds and initiation rates within the spatial replication program in XenopusKathrin Marheineke Paris Cit University France11 15 11 45Single molecule studies of DNA replicationNynke Dekker TU Delft Netherlands11 45 12 00The natural paucity of KIAA0101 PAF15 rate limits PCNA dynamics during unperturbed DNA replicationKumar Somyajit University of Southern Denmark Denmark12 00 13 30Lunch and Meet the Editors 30min at the end of lunch Kerstin Brachhold Advanced Biology Wiley GermanyJuanita Perera FEBS Letters GermanyNele Hug Nature Communications UKJuanita Perera FEBS Letters GermanyEsther Schnapp EMBO Reports GermanyHartmut Vodermaier The EMBO Journal Germany13 30 17 30Session 3 Chromatin replicationEva Petermann and Boris Pfander13 30 14 00How to rebuild heterochromatin after DNA replication and the mitotic tsunami Sara Buonomo The University of Edinburgh UK14 00 14 15Mechanism of de novo chromatin assembly during DNA replicationFrancesca Mattiroli Hubrecht Institute The Netherlands14 15 14 30Establishment Of DNA Replication Programs In The Early EmbryoJason Halliwell The University of Copenhagen Denmark14 30 15 00Mechanisms of Chromatin Reorganization underReplication StressNitika Taneja Erasmus University Medical Center NetherlandsNot available on demand15 00 15 30Coffee Break and Meet the speakersOlivier Hyrien Institut de Biologie de l cole Normale Sup rieure FranceNynke Dekker TU Delft NetherlandsSara Buonomo The University of Edinburgh UKNitika Taneja Erasmus University Medical Center Netherlands15 30 16 00Nucleosome Assembly Epigenetic Inheritance and BeyondQing Li Peking University China16 00 16 15Chromatin replication as a modulator of transcriptional activityCristina Gonz lez Aguilera CABIMER CSIC Spain16 15 16 30The fork protection complex promotes parental histone recycling and epigenetic memoryValentin Flury Max Planck Institute of Immunobiology and Epigenetics Germany16 30 17 00Cohesin mediated DNA loop extrusionJan Michael Peters Research Institute of Molecular Pathology IMP Austria17 00 17 30Flash talks for poster session 145 Yohan An47 Agos Bertolin53 Ammar Danazumi55 Isabel D ez59 Martina Muste Sadurni61 Samson Glaser63 Bennie Lemmens67 Kristi Jensen69 Tom Kache70 Itamar Simon71 Manami Katoh75 Leonie Kollenstart81 Luke Lynch85 Peter Martin89 J r me Poli95 Simone Pelliciari99 Michalis Petropoulos105 Corrado Santocanale109 Nick Rhind111 Koyel Roy119 Diala Shatleh Rantisi129 Marcell Veiner133 Florian Weissmann135 Bart Westendorp137 Ronald Wong141 Hemendra Yadav143 Eman Zaffar145 Masato Kanemaki17 30 19 30Poster Session 1 odd numbers with beer and snacks19 30 21 00Dinner in the canteen21 00 22 30Networking drinks in the ATC rooftop lounge Day 3 Thursday 7 November 2024 Timings Europe CET Speaker09 00 12 30Session 4 Replication stress and fork stabilityMorning chairs Bennie Lemmens and Vincent Pag s08 30 09 00Arrival and coffee09 00 09 30The causes and consequences of replication stressKarlene Cimprich Stanford University USANot available on demand09 30 09 45Fanconi anemia and DNA damage tolerance pathways collaborate during mitotic DNA synthesisAnja Bielinsky University of Virginia USA09 45 10 00Branching of polyubiquitin chains acts as a timing device to orchestrate ubiquitin signalling in the DNA damage bypass pathwayKirill Petriukov Institute of Molecular Biology Germany10 00 10 45Coffee Break and Meet the speakersQing Li Peking University ChinaJan Michael Peters Research Institute of Molecular Pathology IMP AustriaKarlene Cimprich Stanford University USA10 45 11 15Understanding causes and consequences of DNA replication stress in vertebratesVincenzo Costanzo the FIRC Institute of Molecular Oncology Italy11 15 11 30Timing transition region fragile sites in neural progenitor cellsPei Chi Wei German Cancer Research Center DKFZ Germany11 30 12 00Mechanism of replication coupled DNA protein crosslink repairJulian Stingele Ludwig Maximilians Universit t M nchen GermanyNot available on demand12 00 12 15Things fall apart Mechanism of cell cycle arrest by hydroxyureaGrant Schauer Colorado State University USA12 15 12 30Disparate requirements for RAD54L in replication fork reversalMollie Uhrig Colorado State University USA12 30 14 45Lunch14 45 17 15Session 4 Replication stress and fork stabilityAfternoon chairs Thanos Halazonetis and Masato Kanemaki14 45 15 00The DNA replication checkpoint targets the kinetochore to allow relocation of collapsed forks to the nuclear peripheryCatherine Freudenreich Tufts University USA15 00 15 15Single cell multi omic DNA replication sequencing methods uncover DNA replication fork speed dynamics and their regulatorsJeroen van den Berg Hubrecht Institute The Netherlands15 15 15 30Profiling replication fork dynamics with multiplexed TrAEL seqJon Houseley Babraham Institute UK15 30 16 15Coffee Break and Meet the speakersVincenzo Costanzo the FIRC Institute of Molecular Oncology ItalyJulian Stingele Ludwig Maximilians Universit t M nchen Germany16 15 16 30TTF2 promotes mitotic activation of the replisome associated E3 ubiquitin ligase TRAIPGeylani Can Harvard Medical School USA16 30 16 45TTF2 drives mitotic replisome disassembly and MiDAS by coupling the TRAIP ubiquitin ligase to Pol EpsilonKarim Labib University of Dundee UK16 45 17 15Flash talks for poster session 244 Mirit Aladjem46 Benjamin Pardo48 Berta Canal50 Mathilde Courtes54 Brendon Davis66 Gal Jaschek68 Daphne Jurriens72 Eva Petermann74 Ariel Klavaris78 Innesa Leonovich80 Zhaowei Liu86 Vincent Pag s90 Bel n G mez Gonz lez92 Harry Orrin100 Florian Pflug102 Sunil Kumar Pradhan104 Romain Forey120 Chaonan Shi127 Bruno Uri n Gonz lez128 Sidrit Uruci130 Karim Labib134 Marcel Werner140 Anoop Kumar Yadav142 Yue Yao17 15 19 15Poster Session 2 even numbers with beer and snacks19 15 20 45Conference gala dinner in the canteen20 45 00 00Party with DJ Jens in the ATC Foyer and the ATC Rooftop Lounge Day 4 Friday 8 November 2024 Timings Europe CET Speaker09 00 13 00Session 5 Replication in cancer etiology and treatment opportunitiesChairs Helle Ulrich08 30 09 00Arrival and coffee09 00 09 30Investigation and translation of molecular mechanisms for genomic integrity Kyungjae Myung Ulsan National Institute of Science and Technology South Korea09 30 09 45Tissue specificity of human DNA replication origins revealed by strand bias switches in cancer genome mutationsMarina Salvadores Ferreiro University of Copenhagen Denmark09 45 10 00Unravelling the dynamics of single cell DNA replication timing through machine learning reveals a further layer of heterogeneity in cancer progressionChunlong Chen Institut Curie France10 00 10 30RTF2 and replication dynamicsAgata Smogorzewska The Rockefeller University USA10 30 11 30Coffee Break and Meet the speakersKyungjae Myung Ulsan National Institute of Science and Technology South KoreaAgata Smogorzewska The Rockefeller University USAJohn Diffley Key note The Francis Crick Institute UK11 30 11 45DNA sequence motifs link somatic mutagenesis to histone binding at potential DNA replication termination sitesAnna Poetsch Technische Universit t Dresden Germany11 45 12 00Impaired nucleotide metabolism due to p53 deficiency leads to replication stress and triggers a cascade of events that initiates chromothripsisAur lie Ernst German Cancer Research Center DKFZ Germany12 00 13 00Keynote lecture Biochemical approaches to understanding chromosome replicationJohn Diffley The Francis Crick Institute UK13 00 13 15Closing Remarks Thanos HalazonetisPoster Prize AnnouncementsAnja Groth and Helle Ulrich13 15 13 30Packed Lunch and departure13 30Airport shuttle leaves EMBL for Frankfurt Am Main International airport Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site PhD Student 625On site Academia 725On site Industry 925On site Journal Editor 300Virtual PhD Student 175Virtual Academia 225Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact charlotte courtney embl org for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Tuesday 8 October 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 12 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Here is the Conference shuttle bus timetable Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen Sie How are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Media partners Advanced Biology a Wiley Journal Advanced Genetics a Wiley Journal BioEssays a Wiley Journal ChemBioChem a Wiley Journal EMBO Journal an EMBO Press Journal FEBS Letters Genes and Development a Cold Spring Harbor Journal Genome Research a Cold Spring Harbor Journal International Union of Biochemistry and Molecular Biology Journal of Molecuar Biology an Elsevier Journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Wiley Journals Advanced Genetics Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media Kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Anja Groth, Thanos Halazonetis, Helle Ulrich

4 November - 8 November 2024

Structural bioinformatics

Description This course provides a guide to the commonly used methods and tools in structural bioinformatics to analyse and interpret experimentally determined and AI predicted macromolecular structure data Structural biology determining the three dimensional shapes of biomacromolecules and their complexes can tell us a lot about how these molecules function and the roles they play within a cell Data derived from structure determination experiments and Artificial Intelligence AI assisted structure prediction enables life science researchers to address a wide variety of questions This course explores bioinformatics data resources and tools for the investigation analysis and interpretation of both experimentally determined and predicted biomacromolecular structures It will focus on how best to analyse and interpret available structural data to gain useful information given specific research contexts The course content will also cover predicting function and exploring interactions with other macromolecules Successful participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course...

Juanita Riveros

4 November - 8 November 2024

The fundamentals of high-end cell sorting

Description OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview This course includes a robust theoretical part on the fundamentals of cell sorting delivered by world leading experts and practical sessions on using standard cuvette sorters In addition the course program will include principles applications and hands on sessions on Image Cell Sorting ICS allowing attendees to get in touch with this exciting technology Audience The course is intended for Ph D students and postdocs who are starting to use or already using cell sorting in their research projects Applicants with previous active knowledge of basic principles of flow cytometry and regular use of flow cytometers in daily research will profit most from the course content Modules Resources The topics that will be covered include instrument set up and validation correct operation to avoid technical insufficiency sample quality the essentials of gating performing single cell sorts for sequencing and sorting based on morphological traits Learning Outcomes The principle objectives are to deliver the theory of cell sorting and the practical sides of this high end technology What past participants say about the course I am amazed by how inspirational and educational this practical course was People from all over the world joined and together we had a great week learning more about a topic all of us are passionate about Alexandra Vujkovic Institute of Tropical Medicine Belgium Even though the samples I work with are very different from what was demonstrated in the practical I left with many useful techniques not easily found in literature if at all The environment was very lively and the trainers were very eager to answer our questions and feed our curiosity G Y Grace Ho Max Planck Institute for Marine Microbiology Germany This course tought me not only the basics of cell sorting but also a plethora of factors and caveats influencing the outcome of my experiments I feel prepared and confident Tomasz Kaszubowski Universit tsklinikum Erlangen Germany Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Jochen Behrends Research Center Borstel Leibniz Lung Center Germany Derek Davies Cytometry UK Gelo dela Cruz Novo Nordisk Foundation Center for Stem Cell Medicine reNEW Denmark Mark Dessing BD Germany Claudia Dumrese University of Zurich Switzerland Marcus Eich German Cancer Research Center DKFZ Germany Daniel Gimenes EMBL Heidelberg Germany Christopher Hall Babraham Institute UK Desiree Kunkel BIH at Charit Universit tsmedizin Berlin Germany Sophie Novault Institut Pasteur France Diana Ordonez EMBL Heidelberg Germany Beata Ramasz EMBL Heidelberg Germany Marta Rodriguez EMBL Heidelberg Germany Steffen Schmitt German Cancer Research Center DKFZ Germany Moritz Winker EMBL Heidelberg Germany Scientific organisers Diana Ordonez EMBL Heidelberg Germany Malte Paulsen Novo Nordisk Foundation Center for Stem Cell Medicine reNEW Denmark Beata Ramasz EMBL Heidelberg Germany Steffen Schmitt German Cancer Research Center DKFZ Germany Event organisers Maria Bacadare Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Preliminary programme Are you on social media Post using EMBOCellSort and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Please note the below programme is still subject to changes Day 1 Monday 4 November 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 30Welcome and house notes and course overviewBeata Ramasz EMBL Heidelberg GermanyFlex Lab A B09 30 10 30Ice breaker activityAll participants and speakers trainersFlex Lab A B10 30 11 00Coffee BreakFlex Lab A B11 00 12 30Flash talksAll participants and speakers trainersFlex Lab A B12 30 13 30LunchEMBL Canteen13 30 14 15Lecture Fluidics Optics and Signal GenerationGelo dela Cruz Novo Nordisk Foundation Center for Stem Cell Medicine reNEW DenmarkFlex Lab A B14 15 15 00Lecture Streams Nozzles Deflections and DropsDaniel Gimenes EMBL Heidelberg GermanyFlex Lab A B15 00 16 30Discussion session share topics of interest open questionsAll participants and speakers trainersTraining Lab A B16 30 17 00Coffee BreakFlex Lab A B17 00 17 45Lecture The essentials of gating the impact of sample qualityBeata Ramasz EMBL Heidelberg GermanyFlex Lab A B17 45 18 30Lecture Considering downstream applications into your sortingJochen Behrends Research Center Borstel Leibniz Lung Center GermanyFlex Lab A B18 30 20 00DinnerATC Rooftop Lounge20 00Departure to HotelATC Entrance Day 2 Tuesday 5 November 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 10Overview of the dayFlex Lab A B09 10 09 55Lecture Biosafety ConsiderationsSteffen Schmitt DKFZ GermanyFlex Lab A B09 55 10 40Lecture Conventional vs Spectral Flow CytometrySophie Novault Institut Pasteur FranceFlex Lab A B10 40 11 00Coffee breakFlex Lab A B11 00 11 45Lecture Image based Cell SortingMark Dessing BD GermanyFlex Lab A B11 45 12 30Lecture Imaging applications in real lifeMarta Rodriguez EMBL Heidelberg GermanyMoritz Winker EMBL Heidelberg GermanyFlex Lab A B12 30 13 30LunchEMBL Canteen13 30 16 00Discussion session share topics of interest open questionsAll participants and speakers trainersFlex Lab A B16 00 16 30Coffee BreakFlex Lab A B16 30 17 15Lecture How to choose a sorter Claudia Dumrese University of Zurich SwitzerlandFlex Lab A B17 15 18 00Lecture Best analysis toolsChristopher Hall Babraham Institute UKFlex Lab A B18 00 18 45Departure to downtownATC Entrance18 45Dinner downtown Day 3 Wednesday 6 November 2024 Time Europe Berlin SpeakerLocation08 20 08 55Bus from hotel to EMBL ATC Entrance and to DKFZISG Hotel09 00 09 10Overview of the dayFlex Lab A B09 10 10 40Practical Session 2 Running Different Sorter TypesGroup 1 DKFZ Fusion AGroup 2 DKFZ Discover AGroup 3 EMBL Fusion AGroup 4 EMBL Discover AAll speakers trainersDKFZEMBL10 40 11 10Coffee breakFlex Lab A B11 10 12 40Continue Practical Session 2 Running Different Sorter TypesGroup 1 DKFZ Fusion AGroup 2 DKFZ Discover AGroup 3 EMBL Fusion AGroup 4 EMBL Discover AAll speakers trainersDKFZEMBL12 40 13 40LunchEMBL DKFZ Canteen13 40 15 30Practical Session 3 Running Different Sorter TypesGroup 1 DKFZ Fusion BGroup 2 DKFZ Discover BGroup 3 EMBL Fusion BGroup 4 EMBL Discover BAll speakers trainersDKFZEMBL15 30 16 00Coffee breakFlex Lab A B16 00 18 00Continue Practical Session 3 Running Different Sorter TypesGroup 1 DKFZ Fusion BGroup 2 DKFZ Discover BGroup 3 EMBL Fusion BGroup 4 EMBL Discover BAll speakers trainers DKFZEMBL18 00Departure to ISG Hotel DowntownATC Entrance18 00Free evening Day 4 Thursday 7 November 2024 Time Europe Berlin SpeakerLocation08 20 08 55Bus from hotel to EMBL ATC Entrance and to DKFZ ISG Hotel09 00 09 10Overview of the dayFlex Lab A B09 10 10 40Practical Session 4 Running Different Sorter TypesGroup 1 EMBL Discover AGroup 2 EMBL Fusion AGroup 3 DKFZ Discover AGroup 4 DKFZ Fusion AAll speakers trainersEMBLDKFZ10 40 11 10Coffee breakFlex Lab A B11 10 12 40Continue Practical Session 4 Running Different Sorter TypesGroup 1 EMBL Discover AGroup 2 EMBL Fusion AGroup 3 DKFZ Discover AGroup 4 DKFZ Fusion AAll speakers trainersEMBLDKFZ12 40 13 40LunchEMBL DKFZ Canteen13 40 15 30Practical Session 5 Running Different Sorter TypesGroup 1 EMBL Discover BGroup 2 EMBL Fusion BGroup 3 DKFZ Discover BGroup 4 DKFZ Fusion BAll speakers trainersEMBLDKFZ15 30 16 00Coffee breakFlex Lab A B16 00 18 00Continue Practical Session 5 Running Different Sorter TypesGroup 1 EMBL Discover BGroup 2 EMBL Fusion BGroup 3 DKFZ Discover BGroup 4 DKFZ Fusion BAll speakers trainersEMBLDKFZ18 00 18 30Departure to ISG Hotel DowntownATC Entrance18 30Dinner and bowling Day 5 Friday 8 November 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 10Overview of the dayFlex Lab A B09 10 09 55Lecture Best practicesD sir e Kunkel BIH at Charit Universit tsmedizin Berlin GermanyFlex Lab A B09 55 10 40Lecture Tips for publishing high quality cytometry dataDerek Davies Cytometry UKFlex Lab A B10 40 11 10Coffee BreakFlex Lab A B11 10 12 40Interactive discussion session Troubleshooting tips and tricksBeata Ramasz EMBL Heidelberg GermanyDiana Ordonez EMBL Heidelberg GermanyFlex Lab A B12 40 13 40LunchEMBL Canteen13 40 14 40Feedback and discussionFlex Lab A B14 40Departure to Heidelberg Train Station and DowntownEMBL Bus Stop ATC Entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation in single rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of Sunday 3 to Friday 8 November 5 nights Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event Sponsor Event Supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Beata Ramasz, Diana Ordonez

31 October 2024

Programmatic access to UniProt using Python

Description UniProt is a comprehensive expert led publicly available database of protein sequence function and variation information This webinar will give an overview of programmatic access to the UniProt database using Python and cover key aspects of protein entry searches data filtering batch downloads and give examples of further processing of downloaded target data Following a brief introduction to UniProt services where to find relevant documentation and help features the webinar will focus on worked examples These will include how to programmatically search and retrieve protein entries and sequences within the results we will then show how to align orthologous sequences and filter for features of interest The webinar will also cover programmatic examples of the UniProt ID mapping service batch downloads filtering and processing data You can also access the Google Colab used during the webinar...

29 October - 31 October 2024

Managing a bioinformatics core facility

Description This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL EBI s service teams and from each other These facilities play an essential role in enabling research in the life sciences The landscape is constantly evolving as new research tools emerge as experiments become increasingly data intensive and as their users experimental researchers become more exposed to the power of data driven biology This course will allow participants to share experiences discuss challenges and solutions that they face and plan ways to cope with the ever changing demands raised by the molecular life science field It will include sessions to learn from bioinformatics service providers hear how others have tackled common problems and work together to design core services resource them and measure their impact A limited number or travel bursaries are available Please see the Additional information tab for conditions...

Barbara Etzi

23 October 2024

I made my code open - now what? Steps to a thriving open software project

Description Sharing your code is a good first step towards building open source software but it is not enough to ensure its success This webinar focuses on practical issues to increase impact of open software projects including maintenance community building discoverability project management documentation licensing and user needs Our speakers will share their experience working with the open source code as part of the CAPITAL project open source tool that uses machine learning to identify biological concepts from text and link them to relevant ontologies They will discuss the challenges they have encountered and potential solutions to address these...

21 October - 26 October 2024

Imaging down to single-molecule resolution: STED & MINFLUX nanoscopy

Description OverviewSpeakers trainers and staffProgrammePractical informationSponsorsMedia kit Overview Course overview The aim of the course is to train microscopy users in different super resolution microscopy methods Stimulated Emission Depletion STED and MINFLUX nanoscopy Both techniques overcome the diffraction limit of light with the help of a donut shaped laser beam thereby achieving resolutions that are impossible with conventional light microscopy The course combines scientific lectures by experienced researchers from the super resolution field with hands on sessions at the different super resolution microscopes and in the laboratory Participants will gain a technical understanding of the methods as well as an overview of different application fields and imaging techniques sample preparation and data handling for both STED and MINFLUX After the course participants can choose the right approach for their experimental needs and perform their experiments on a STED or MINFLUX microscope Audience Aimed at early stage researchers e g pre or post doctoral level in the life sciences with access to STED and MINFLUX super resolution microscopy facilities and at imaging facility staff involved in training and supporting scientists using STED and MINFLUX super resolution microscopy Participants should have an immediate need to apply these techniques The course will have a strong emphasis on the practical know how needed to exploit the latest developments in STED and MINFLUX microscopy It is therefore equally suited to scientists who are already using super resolution microscopy in their research and to researchers using advanced imaging techniques who wish to improve their practical knowledge Modules Theory and applications of STED and MINFLUX microscopy Sample preparation for STED and MINFLUX super resolution imaging 2D and 3D STED imaging as well as multicolour live cell tissue and fluorescence lifetime STED imaging 2D and 3D MINFLUX imaging MINFLUX tracking STED and MINFLUX microscopy data handling Learning outcome At the end of the course participants will be able to plan an experiment using STED and MINFLUX super resolution microscopy prepare their own samples accordingly acquire images using optimal conditions and settings and analyse them using appropriate methods and tools Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course Speakers trainers and staff Speakers trainers and staff Francesca Bottanelli Freie Universit t Berlin Germany Alexander Carsten University Hospital Hamburg Eppendorf Germany Jan Ellenberg EMBL Heidelberg Germany Stefan Hell Max Planck Institute for Biophysical Chemistry Germany Jan Maximilian Janssen Johannes Kepler Universit t Linz Austria Rohan Kapoor Universit t G ttingen Germany Grazvydas Lukinavicius Max Planck Institute for Multidisciplinary Sciences Germany Raphael Mercier Max Planck Institute for Plant Breeding Research Germany Francesca Pennacchietti KTH Royal Institute of Technology Sweden Jonas Ries University of Vienna Austria Carmen Rodilla Freie Universit t Berlin Germany Arina Rybina EMBL Heidelberg Germany Till Stephan Max Planck Institute for Multidisciplinary Sciences Germany Rifka Vlijm University of Groningen The Netherlands Kruno Vuku i Ru er Bo kovi Institute Croatia Scientific organisers Clara G rth Abberior Instruments Germany Charlotte Kaplan Bioquant Universit t Heidelberg Germany Marko Lampe EMBL Heidelberg Germany Ulf Matti Abberior Instruments Germany Julia Menzel Abberior Instruments Germany Sebastian Schnorrenberg EMBL Heidelberg Germany Course organisers Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Karoline Wolkersdorfer Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLSTED MINFLUX and don t forget to tag EMBLEvents Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 21 October 2024 TimeDescriptionLocation08 40Bus from ISG to EMBL Imaging CenterISG Hotel09 00 09 30Welcome and house notes incl safety Imaging Center Lecture Hall09 30 10 00Course overviewImaging Center Lecture Hall10 00 11 00Lecture 1 Overview of Super resolution TechniquesMarko Lampe DKFZ Heidelberg Germany Sebastian Schnorrenberg EMBL Heidelberg GermanyImaging Center Lecture Hall11 00 11 30Coffee BreakImaging Center Lecture Hall11 30 12 15Lecture 2 What limits meiotic crossovers remote Raphael Mercier Max Planck Institute for Plant Breeding Research GermanyImaging Center Lecture Hall12 15 13 15LunchCanteen13 15 14 15Introduction round 1Imaging Center Lecture Hall14 15 14 30Coffee breakImaging Center Lecture Hall14 30 15 30Lecture 3 Imaging the molecular processes of cell division across scalesJan Ellenberg EMBL Heidelberg GermanyImaging Center Lecture Hall15 30 15 45Coffee breakImaging Center Lecture Hall15 45 16 30Lecture 4 MINFLUX for dynamic structural cell biology remote Jonas Ries University of Vienna AustriaImaging Center Lecture Hall16 30 19 00Practical 1Imaging Center Labs19 00 20 00DinnerCanteen20 00Departure to ISGATC Bus Stop Day 2 Tuesday 22 October 2024 TimeDescriptionLocation08 40Bus from ISG to EMBL Imaging CenterISG Hotel09 00 09 05Overview of the dayImaging Center Lecture Hall09 05 09 50Lecture 5 Unravelling the inner secrets of cells with gene editing and live cell STED microscopy remote Fran Botanelli Freie Universit t Berlin GermanyImaging Center Lecture Hall09 50 10 00Coffee BreakImaging Center Lecture Hall10 00 12 15Introduction round 2Imaging Center Lecture Hall12 15 13 30LunchCanteen13 30 16 00Practical 2Imaging Center Labs16 00 16 30Coffee BreakImaging Center Lecture Hall16 30 19 00Practical 3Imaging Center Labs19 00 20 00DinnerCanteen20 00Departure to ISGATC Bus Stop Day 3 Wednesday 23 October 2024 TimeDescriptionLocation09 30Bus from ISG to EMBL Imaging CenterISG Hotel09 45 09 50Overview of the dayImaging Center Lecture Hall09 50 10 35Lecture 7 Sharpening the focus STED microscopy in unveiling the mysteries of mitotic spindles across speciesKruno Vuku i Ru er Bo kovi Institute CroatiaImaging Center Lecture Hall10 35 11 15Coffee BreakImaging Center Lecture Hall11 15 12 00Lecture 8 Optimal STED from archaea to human cells remote Rifka Vlijm University of Groningen The NetherlandsImaging Center Lecture Hall12 00 12 30Lecture 9 Euro BioImaging ERIC Opportunities for open access to state of the art imaging expertise and technologiesMarianna Childress Poli EMBL Heidelberg GermanyImaging Center Lecture Hall12 30 13 30LunchCanteen13 30 16 00Practical 4Imaging Center Labs16 00 16 30Coffee BreakImaging Center Lecture Hall16 30 19 00Practical 5Imaging Center Labs19 00 20 00DinnerCanteen20 00Departure to ISGATC Bus Stop Day 4 Thursday 24 October 2024 TimeDescriptionLocation08 40Bus from ISG to EMBL Imaging CenterISG Hotel09 00 09 05Overview of the dayImaging Center Lecture Hall09 05 09 50Lecture 10 A niche within the niche Connexins at the AISJan Maximilian Janssen Johannes Kepler University Linz AustriaImaging Center Lecture Hall09 50 10 00Coffee BreakImaging Center Lecture Hall10 00 12 30Practical 6Imaging Center Labs12 30 13 30LunchCanteen13 30 16 00Practical 7Imaging Center Labs16 10Departure to Heidelberg downtown via ISG HotelATC Bus stop17 00 21 00Course dinner and bowling downtown at FirebowlHeidelberg downtown Day 5 Friday 25 October 2024 TimeDescriptionLocation08 40Bus from ISG to EMBL Imaging CenterISG Hotel09 00 09 05Overview of the dayImaging Center Lecture Hall09 05 09 50Lecture 11 Charting the nanotopography of inner hair cell ribbon synapsesRohan Kapoor Universit t G ttingen GermanyImaging Center Lecture Hall09 50 10 35Lecture 12 Visualizing bacterial infections at the nanoscaleAlexander Carsten Universit tsklinikum Hamburg Eppendorf GermanyImaging Center Lecture Hall10 35 11 00Coffee BreakImaging Center Lecture Hall11 00 11 45Lecture 13 Exploring Photocontrollable Fluorescent Protein for Live Cell Imaging at the NanoscaleFrancesca Pennacchietti KTH Royal Institute of Technology SwedenImaging Center Lecture Hall11 45 12 30Lecture 14 Investigating the structure and dynamics of mitochondria at the nanoscaleTill Stephan Max Planck Institute for Multidisciplinary Sciences GermanyImaging Center Lecture Hall12 30 13 20LunchCanteen13 20 13 30Group photoin front of the Imaging Center13 30 14 30Keynote Lecture 15 Molecule scale resolution and dynamics in fluorescence microscopyStefan Hell Max Planck Institute for Biophysical Chemistry GermanyImaging Center Lecture Hall14 30 16 30Practical 8Imaging Center Labs16 30 16 45Coffee BreakImaging Center Lecture Hall16 45 19 15Practical 9Imaging Center Labs19 15 20 00DinnerCanteen20 00Departure to ISGATC Bus Stop Day 6 Saturday 26 October 2024 TimeDescriptionLocation08 40Bus from ISG to EMBL Imaging CenterISG Hotel09 00 11 30Practical 10Imaging Center Labs11 30 12 30LunchCanteen12 30 15 00Practical 11Imaging Center Labs15 00 16 00Final discussion feedback round and closing remarksImaging Center Lecture Hall16 00Bus to Heidelberg train station via Hilton hotelATC Bus Stop Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee Participants are expected to book and pay their own accommodation and travel expenses Academia 700PhD Student 700Industry 1250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights 20 26 October 2024 at ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course EIC24 01 by the deadline of 23 September 2024 We recommend that all course participants stay in the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the course an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Imaging and Microscopy a Wiley magazine Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Clara Gürth, Charlotte Kaplan, Marko Lampe, Ulf Matti, Julia Menzel, Sebastian Schnorrenberg

16 October 2024

Spatial multi-omics integration: metabolites meet RNA

Description Recently emerged spatial omics technologies provide unprecedented insights into spatial aspects of gene expression protein localisation and metabolite concentrations in tissues Now the increasingly recognised challenge lies in integrating layers of individual spatial omics into a multi omics molecular inventory describing cellular machinery and its spatial co organisation across transcription translation and metabolism This webinar will focus on spatial metabolomics and cover various computational approaches for analysing Spatial multi omics datasets emphasising the integration of transcriptomics and metabolomics at both spatial and single cell resolution It will elucidate the core principles of each method and their application to key biological questions in the spatial omics domain Additionally a case study will be presented to demonstrate the effectiveness of these methods on a combined dataset of spatial metabolomics and highly multiplex RNA FISH...

15 October - 18 October 2024

The complex life of RNA

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Before the genetic information stored in DNA can be used to direct cell growth and metabolism it has to be transferred into RNA Messenger RNAs mRNAs that code for proteins and noncoding RNAs are key components in the transmission of genetic information in all life forms from viruses to complex mammalian organisms Following the great success of the 2022 edition of this long standing symposium we are looking forward to returning in 2024 bringing together leaders in the RNA field post docs and students with the aim of disseminating and discussing the most recent results The programme will include topics on transcription RNA processing and modification mRNA export and localisation mRNA surveillance and decay translation the activity of non coding RNAs the control of mRNA expression and coupling among these processes Session topics Co transcriptional RNA biology RNA processing and modification RNP on the move Co translational RNA biology RNA structure and regulation RNA pathogens and therapeutics What past participants say about the Symposium The Complex Life of RNA is the key event in RNA biology It is incredibly difficult to represent this complex area of knowledge but the organisers succeeded in decomposing the complexity Alexey Moskovtsev Institute of General Pathology and Pathophysiology Moscow Russia Mind blowing science fresh from the bench and presented by top experts a truly rewarding experience Peer Staehler BASF New Business GmbH Germany While I was at The Complex Life RNA symposium held at EMBL I was able to present my work as a poster to several researchers One such researcher from Norway got interested in my work and offered to host me for a short term in his lab to enhance my current project After several correspondences I was able to design a project that could also potentially start a collaboration between my home lab in India and his lab in Norway I applied for the EMBO STF fellowship and I was successful in securing this grant for my visit to Norway So I believe attending this conference was a great boost for my scientific career Preeti Kute Institute for Stem Cell Biology and Regenerative Medicine India Speakers Keynote speakers Matthew Disney The Wertheim UF Scripps Institute USA Lori Passmore MRC Laboratory of Molecular Biology UK Speakers Julius Brennecke Institute of Molecular Biotechnology Austria Yiliang Ding John Innes Centre UK Wojtek Galej EMBL Grenoble France Britt Glaunsinger University of California Berkeley USA Tetsuro Hirose Osaka University Japan Hailing Jin University of California Riverside USA Claudia Keller Valsecchi Institute of Molecular Biology Germany Herv Le Hir cole normale sup rieure France Kelly Nguyen MRC Laboratory of Molecular Biology UK Lucas Pelkmans University of Zurich Switzerland Michal Rabani Hebrew University of Jerusalem Israel Schraga Schwartz Weizmann Institute of Science Israel Sichen Susan Shao Harvard Medical School USA Marvin Tanenbaum Hubrecht Institute The Netherlands Juan Valc rcel Ju rez Centre for Genomic Regulation Spain Robert Weatheritt Garvan Institute of Medical Research EMBL Australia Australia Scientific organisers Elena Conti Max Planck Institute of Biochemistry Germany Olivier Duss EMBL Heidelberg Germany Torben Heick Jensen Aarhus University Denmark Karla Neugebauer Yale School of Medicine USA Conference organisers Iva Gavran Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EESRNA and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 15 October 2024 Time Europe Berlin Speaker17 00 18 30Registration and pre dinner drinks18 30 20 00Dinner in Canteen20 00 20 15Opening remarks20 15 21 00Keynote lecture Molecular insights into the mRNA poly A tail machinery Lori Passmore MRC Laboratory of Molecular Biology UK21 00 22 30Networking drinks and poster Sneak preview Day 2 Wednesday 16 October 2024 Time Europe Berlin Speaker09 00 12 15Session 1 co transcriptional RNA biologyChairs Karla Neugebauer and Martin Mikl 09 00 09 25Molecular mechanism of human telomerase ribonucleoproteinKelly Nguyen MRC Laboratory of Molecular Biology UKNot available on demand09 25 09 40Real time tracking of early ribosomal RNA transcription and processing Anastasiia Chaban EMBL Heidelberg Germany09 40 09 55EIF4A3 prevents widespread coordinated exon skipping across human genes Alexandra Bergfort Yale University USA09 55 10 20Epigenetics of sex differencesClaudia Keller Valsecchi Institute of Molecular Biology Germany10 20 10 50Coffee Break and Meet the speakers with Lori Passmore Kelly Nguyen and Claudia Keller Valsecchi10 50 11 05Periphilin directs RNA mediated epigenetic silencing by the human silencing hub HUSH complex Beth Thompson The University of Cambridge MRC Laboratory of Molecular Biology United Kingdom11 05 11 20Uncovering the dynamics and consequences of RNA isoform changes during cell differentiation Andreas Mayer Max Planck Institute for Molecular Genetics GermanyNot available on demand11 20 11 45Multifaceted roles of Satellite RNAs in the nucleus and cytoplasmTetsuro Hirose Osaka University Japan11 45 12 15Flash talks odd numbers 59 Enes Arpa 69 Carrie Bernecky 91 Brennan Danlasky 115 Asen Garbelyanski 123 Odil Porrua 141 Daniel Hofacker 143 Mohamed Fareh 203 Daphna Nachmani 221 Clemens Plaschka 285 Nurseda Yilmaz Demirel12 15 13 45Lunch and Meet the Editors introduction before lunch 13 45 16 15Poster Session 1 odd numbers with snacksPoster list 16 15 19 00Session 2 RNA processing and modificationChairs Katharina H fer and Mathieu Rougemaille16 15 16 40Structural studies of the U12 dependent intron recognitionWojtek Galej EMBL Grenoble France16 40 16 55Molecular principles of uridylation mediated RNA decay in Drosophila insights from massive parallel enzymatic profiling and kinetic modeling Annamaria Sgromo Max Perutz Labs University of Vienna Vienna BioCenter AustriaNot available on demand16 55 17 10Identification of a m6Am reader and its function in mRNA transcription W S Sho Goh Shenzhen Bay Laboratory China17 10 17 40Coffee Break and Meet the speakers with Tetsuro Hirose and Wojtek Galej17 40 18 05P bodies a novel regulator of cell cycle progressionRobert Weatheritt Garvan Institute of Medical Research EMBL Australia AustraliaNot available on demand18 05 18 20Disruption of the Integrator complex triggers the Integrated Stress Response through formation of double stranded RNA Apoorva Baluapuri Harvard Medical School USA18 20 18 35Stabilization of excised introns in yeast Glenn Li Massachusetts Institute of Technology Whitehead Institute HHMI USANot available on demand18 35 19 00Two simple models for m6A deposition and dynamicsSchraga Schwartz Weizmann Institute of Science Israel19 00 20 30Dinner in EMBL Canteen20 30 22 00Informal Poster Session 1 with drinks Day 3 Thursday 17 October 2024 Time Europe Berlin Speaker09 00 12 15Session 3 RNP on the moveChairs Sebastian Falk and Oliver M hlemann09 00 09 25Lighting and dimming the EJC illuminate mRNPsHerv Le Hir cole normale sup rieure France09 25 09 40Compositional variability of the exon junction complexMarcela Cueto Max Planck Institute of Biochemistry Germany09 40 09 55A kinetic framework for co transcriptional messenger ribonucleoprotein mRNP assembly in S cerevisiaeTheresa Wechsler University of California Davis USA09 55 10 20Cross kingdom RNA communicationHailing Jin University of California Riverside USA10 20 10 50Coffee Break and Meet the speakers with Robert Weatheritt Herv Le Hir and Hailing Jin10 50 11 05Tag with caution how most tags influence biomolecular condensation in vivo and in vitroMaria Hondele University of Basel Switzerland11 05 11 20Molecular basis for determining the fate of nuclear polyadenylated RNA Ana Lorenzo Aarhus University Denmark11 20 11 45A comparative analysis across species of maternal mRNA regulation in embryosMichal Rabani Hebrew University of Jerusalem Israel11 45 12 15Flash talks even numbers 70 Eva Kowalinski 102 Joe Dobbs 112 Toru Fujiwara 114 Matti Turtola 154 Sebastian Kadener 158 Jirka Peschek 196 Abdallah Mohamed 242 Marcos Manero Carranza 272 Teun van der Klugt12 15 13 45Lunch 13 45 16 15Poster Session 2 even numbers with snacksPoster list 16 15 19 00Session 4 co translational RNA biologyChairs Kathrin Leppeck and Olivier Duss 16 15 16 40RSV viral ribonucleoprotein vRNP state coordinates infection successMarvin Tanenbaum Hubrecht Institute The Netherlands16 40 16 55A genome wide screen reveals that oxidative stress regulates translation elongation to promote production of detoxifying selenoproteinsFrederick Rehfeld University of Texas Southwestern Medical Center Dallas USA16 55 17 10Translation dependent mRNA localization to apical junctionsCristina Tocchini University of Basel SwitzerlandNot available on demand17 10 17 50Coffee Break and Meet the speakers with Michal Rabani and Marvin Tanenbaum17 50 18 15Quality control of translation componentsSusan Shao Harvard Medical School USA18 15 18 30The hsp90 r2tp chaperone mediates co translational channeling of quaternary structure formation Manon Philippe French National Centre for Scientific Research CNRS France18 30 18 45Identification and characterization of novel quality control factors on the ribosome Junyi He Technion Israel Institute of Technology Israel18 45 19 00The regulatory landscape of 5 UTRs in translational control during zebrafish embryogenesis Madalena Reimao Pinto Biozentrum University of Basel Switzerland19 00 20 30Dinner in EMBL Canteen20 30 22 00Informal Poster Session 2 with drinks Day 4 Friday 18 October 2024 Time Europe Berlin Speaker09 00 12 00Session 5 RNA structure and regulationChairs Mandy Jeske and Antonio Giraldez09 00 09 25Buffering and homeostasis of transcript abundance through nuclear retentionLukas Pelkmans University of Zurich Switzerland09 25 09 40H ACA snR30 snoRNP guides independent 18S rRNA subdomain formation Matthias Thoms Ludwig Maximilians University of Munich GermanyNot available on demand09 40 09 55The number of physiologically important microRNA targets has been vastly overestimated Herv Seitz CNRS France09 55 10 20RNA structure an important regulator in living cellsYiliang Ding John Innes Centre UK10 20 10 50Coffee Break and Meet the speakers with Susan Shao Lukas Pelkmans and Yiliang Ding10 50 11 05Direct visualisation of Xist RNA mediated X chromosome inactivation using in situ cryogenic electron Tomography Jeongyoon Choi University of Oxford United Kingdom11 05 11 20Codon usage bias the unwanted transcript hypothesisSofia Radrizzani University of Bath United Kingdom11 20 11 35Single molecule RNA structure maps using nanopore sequencing Oguzhan Begik Centre for Genomic Regulation CRG Spain11 35 12 00Target engagement of a nuclear Argonaute proteinJulius Brennecke IMBA Institute of Molecular Biotechnology Austria12 00 13 30Lunch13 30 17 20Session 6 RNA pathogens and therapeuticsChairs Minna Liisa Anko13 30 13 55Transcriptome wide splicing network reveals specialized regulatory functions of the core spliceosomeJuan Valc rcel Ju rez Centre for Genomic Regulation CRG Spain13 55 14 10Mechanism of CCR4 NOT inhibition by a bacterial pathogen effector Eugene Valkov National Cancer Institute USA14 10 14 25The interplay between a plant virus and the host splicing machinery uncovers a novel virulence mechanism Delphine Pott Center for Plant Molecular Biology ZMBP Germany14 25 14 55Coffee Break and Meet the speakers with Julius Brennecke and Juan Valc rcel Ju rez14 55 15 10Use of poly A tail mimetics to enhance expression of genes associated with human haploinsufficiency disorders Bahareh Torkzaban Johns Hopkins University USA15 10 15 25Using programmable synthetic RNA and protein granules to molecularly encode decoy like antiviral therapeutics Roee Amit Technion Israel Institute of Technology Israel15 25b 15 40Elucidating the interplay between HIV RNA packaging and nonsense mediated mRNA decayDylan Weninger University of Western Ontario Canada15 40 16 10Coffee Break and Meet the speakers with Britt Glaunsinger and Matthew Disney16 10 16 35Cytoplasmic mRNA decay by viral and anti viral nucleases promotes transcriptional repressionBritt Glaunsinger University of California Berkeley USA16 35 17 20Keynote lecture Sequence based design of small molecules targeting RNA structuresMatthew Disney The Wertheim UF Scripps Institute USA17 20 17 35Closing remarks and poster prize17 35 18 30Pre dinner drinks in the Foyer18 30 20 30Gala dinner in EMBL Canteen20 30 23 45Conference party in the Foyer with The Wright Thing Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editor 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Iva Gavran for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 17 September 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 11 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings BUS SCHEDULE The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen Sie How are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged 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on our Information for participants page Sponsors Bronze sponsor Event sponsor New England Biolabs NIPPON Genetics EUROPE siTOOLs Biotech Watchmaker Genomics Zymo Research Europe Event supporters Media partners Advanced Biology a Wiley Journal Advanced Genetics a Wiley Journal BioEssays a Wiley Journal ChemBioChem a Wiley Journal Current Opinion in Sturctural Biology an Elsevier Journal Current Research in Structural Biology an Elsevier Journal EMBO Journal an EMBO Press Journal FEBS Letters Genes and Development a Cold Spring Harbor Journal Genome Research a Cold Spring Harbor Journal International Union of Biochemistry and Molecular Biology Journal of Cell Science The Company of Biologists Journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Wiley Journals Advanced Genetics Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine 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sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Elena Conti, Olivier Duss, Torben Heick Jensen, Karla Neugebauer

13 October - 18 October 2024

Metabolite and species dynamics in microbial communities

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This is a two hub course taking place in parallel at both EMBL Heidelberg Germany and the Bangalore Life Science Cluster BLiSC Campus in Bangalore India Applicants can apply for either location and are encouraged to apply for the one that is closest to them Course overview Metagenomics studies are rapidly uncovering the compositional richness of microbial communities in diverse habitats ranging from the oceans to the human gut While their fundamental role in our health and environment is undeniable there is an urgent need for unravelling molecular mechanisms underlying the dynamics of these communities This requires a combined experimental and computational approach Recent studies including those from the organisers and speakers labs have underlined the success of such integrative approaches For example emergence of cell subpopulations Varahan et al eLife 2019 2020 and long term stability Blasche Kim et al Nat Microbiol 2021 through metabolic cross feeding As researchers world wide map species dynamics in the ecosystems of their interest this course will provide the necessary overview and tools for moving from cataloguing to identifying key interaction agents especially metabolites This will include integrating species and metabolite dynamics data as well as leveraging the power of genome scale metabolic models to predict community interactions Audience This course is aimed at PhD students and post doctoral researchers who would apply the methods covered in the course Applicants are requested to send a motivation letter summarizing their current research and their need for the methods addressed in this course Furthermore there is a specific questionnaire to query the background and access to the relevant methods We aim for a broad geographical distribution of participants to identify needs for applying the methods in different countries this includes newer EU member states To ensure optimal tutoring during the practicals wetarget for 20 participants 10 each site The course will bring together participants from various disciplines microbiology metabolomics modelling ecology and ensure a distribution on both sites Modules Resources Experimental design and kefir culture set up and sampling 16S analysis of kefir communities using Nanopore sequencing technology Metabolite changes during kefir fermentation using Metabolomics Interaction mapping plating experiment Computational analysis introduction using R studio Python 16S and metabolomics data analysis computational Metabolic modelling of community interactions computational Learning outcomes The main goal of the course is to equip the participants with the state of the art concepts in microbial ecosystems and introduce them to the key tools towards gaining mechanistic insights in community dynamics The central learning objective is that the participants will be able to apply these concepts and tools in their own research Further we also aim at enabling scientific networking among the participants including speakers and trainers and foster dialogue between scientists from different areas microbiology metabolomics modelling ecology What past participants say about the course The two hub course organised by EMBL was a great success where participants like me not only learnt wet lab techniques like LC MS but also learnt data visualisation using R and python which will be a great help while analysing our own data Nidhi Yadav ICGEB New Delhi India This EMBO course was very well organised and provided me essential tools and new approaches that I will apply in my research to study metabolic interactions within microbial communities The combination of wet and dry lab techniques as well as the involvement of two hubs in Germany and India made the course very complete and enriching Laura Camus IMIT University of T bingen Germany This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Speakers trainers and staff Deepa Agashe National Centre for Biological Sciences India Course hub Bangalore Renato Alves EMBL Heidelberg Germany Course hub Heidelberg Simran Aulakh University of Cambridge United Kingdom Course hub Bangalore Bartosz Jan Bartmanski EMBL Heidelberg Germany Course hub Heidelberg Sonja Blasche University of Cambridge United Kingdom Course hub Bangalore Katherine Coyte University of Manchester United Kingdom Virtual speaker Matthias Gross EMBL Heidelberg Germany Course hub Heidelberg Amrita Hazra Indian Institute of Science Education and Research Pune India Course hub Bangalore Zachariah Henseler EMBL Heidelberg Germany Course hub Heidelberg Christian Kost University of Osnabrueck Germany Course hub Heidelberg Sunil Laxman Institute for Stem Cell Biology and Regenerative Medicine India Course hub Bangalore Nitish Malhotra University of California Irvine USA Course hub Bangalore Ganesh Muthu Institute for Stem Cell Science and Regenerative Medicine India Course hub Bangalore Niranjan Nagarajan Genome Institute of Singapore A STAR National University of Singapore Singapore Course hub Bangalore Jan Provaznik EMBL Heidelberg Germany Course hub Heidelberg Emily Putnam Middlebury College USA Virtual speaker Pratibha Sanjenbam National Center For Biological Sciences India Course hub Bangalore Denise Selegato EMBL Heidelberg Germany Course hub Heidelberg Fabian Springer EMBL Heidelberg Germany Sreesa Sreedharan Institute for Stem Cell Science and Regenerative Medicine India Course hub Bangalore Rajalakshmi Srinivasan Institute of Bioinformatics and Applied Biotechnology India Course hub Bangalore Laura Villacorta EMBL Heidelberg Germany Course hub Heidelberg Julia Vorholt ETH Zurich Switzerland Course hub Heidelberg Daphne Welter EMBL Heidelberg Germany Course hub Heidelberg Maria Zimmerman Kogadeeva EMBL Heidelberg Germany Course hub Heidelberg Francisco Zorrilla University of Cambridge United Kingdom Course hub Bangalore Scientific organisers Sunil Laxman Institute for Stem Cell Biology and Regenerative Medicine India Course hub Bangalore Kiran Patil University of Cambridge United Kingdom Course hub Heidelberg Elisabeth Zielonka EMBL Heidelberg Germany Course hub Heidelberg Maria Zimmermann Kogadeeva EMBL Heidelberg Germany Course hub Heidelberg Course organisers Irena Provaznikova Scientifc Training Manager EMBL Heidelberg Germany Course hub Heidelberg Nathalie Sneider Course and Conference Manager EMBL Heidelberg Germany Course hub Heidelberg Programme Are you on social media Post using EMBOMicroCom and don t forget to tag EMBLEvents Day 0 Monday 30 September 2024 TimeEurope BerlinSpeakerTimeIndia Bangalore10 00 10 30On Boarding Day Welcome and short introduction13 30 14 0010 30 11 00Course overview on eCampus introduction to pre course work14 00 14 3011 00 11 30Software test for pre course work14 30 15 0011 30 12 00Speed networking between cross site participants15 00 15 30 Day 1 Sunday 13 October 2024 TimeEurope BerlinSpeakerTimeIndia BangaloreZoom link for the day shared in eCampus11 20Heidelberg hub Shuttle from ISG Hotel to EMBL Light lunch upon arrival at EMBL11 30 12 00Heidelberg hub and Bangalore hub registration and technical set up15 00 15 3012 00 12 15Welcome and house notes shared via Zoom at both sites jointTreasure hunt challenge introduced 15 30 15 4512 15 12 45Course overview Introduction to format expectations timelines Sonja Blasche University of Cambridge UK Maria Zimmermann EMBL Heidelberg Germany15 45 16 1512 45 14 15Flash Talks by participants organisers trainers speakers concurrent coffee break 16 15 17 4514 15 15 15Lecture 1 The leaf microbiota disassembling and rebuilding to explore plant microbe interactionsJulia Vorholt ETH Zurich Switzerland17 45 18 4515 15 15 30Coffee break18 45 19 0015 30 16 15Practical session 1 Kefir culture inoculationHeidelberg hub trainers Matthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg GermanyBangalore trainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UKGanesh Muthu Institute for Stem Cell Science and Regenerative Medicine IndiaSreesa Sreedharan Institute for Stem Cell Science and Regenerative Medicine IndiaRajalakshmi Srinivasan Institute of Bioinformatics and Applied Biotechnology India19 00 19 45Bangalore hub Dinner followed by networking19 45 21 1516 15 17 30Heidelberg hub Challenges and Expectations followed by networking timeKiran Patil University of Cambridge UKElisabeth Zielonka EMBL Heidelberg GermanyMaria Zimmermann EMBL Heidelberg Germany17 30 17 45Heidelberg hub Bus from EMBL to the ISG Hotel18 00 20 00Heidelberg hub Dinner at the ISG Hotel followed by networking Day 2 Monday 14 October 2024 TimeEurope BerlinSpeakerTimeIndia BangaloreZoom link for the day shared in eCampusBangalore hub Overview of the dayNitish Malhotra University of California Irvine USA09 00 9 15Bangalore hub Networking Challenges and expectationsSonja Blasche University of Cambridge UKNitish Malhotra University of California Irvine USA 09 15 10 15Bangalore hub Coffee break10 15 10 30Bangalore hub Practical session 1 Experimental design and kefir culture set up and samplingTrainers Sonja Blasche University of Cambridge UKGanesh Muthu Institute for Stem Cell Science and Regenerative Medicine IndiaSreesa Sreedharan Institute for Stem Cell Science and Regenerative Medicine India10 30 11 30Bangalore hub Practical session 4 Interaction mapping plating experiment inoculate background platesTrainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UKPratibha Sanjenbam National Center For Biological Sciences India11 30 12 30Bangalore hub Lunch12 30 13 3008 40Heidelberg hub Bus from ISG Hotel to EMBL08 55 09 00Heidelberg hub Overview of the dayMatthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg Germany09 00 10 00Heidelberg hub Practical session 1 Experimental design and kefir culture set up and samplingTrainers Matthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg Germany10 00 11 00Lecture 2 Inter species interactions in the insect gutDeepa Agashe National Center For Biological Sciences India13 30 14 3011 00 11 15Coffee break14 30 14 4511 15 12 15Lecture 3 Probing the role of microbial communities in human health with genomic toolsNiranjan Nagarajan Agency for Science Technology and Research A STAR Singapore14 45 15 4512 15 12 45Heidelberg hub Practical session 4 Interaction mapping plating experiment prepare plating experiment inoculate background platesTrainers Matthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg Germany12 45 13 45Heidelberg hub LunchBangalore hub Practical session 1 continued Experimental design and kefir culture set up and samplingTrainers Sreesa Sreedharan Ganesh Muthu Institute for Stem Cell Science and Regenerative Medicine India Pratibha Sanjenbam National Center For Biological Sciences15 45 16 45Bangalore hub Practical session 4 continued Interaction mapping plating experiment array species plate and pinTrainers Trainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UKPratibha Sanjenbam National Center For Biological Sciences India16 45 18 0013 45 14 30Heidelberg hub Practical session 1 continued Experimental design and kefir culture set up and samplingTrainers Matthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg Germany14 30 15 00Coffee break and cross site interaction via Zoom in small groups grouped on topics challenges from projects 18 00 18 3015 00 16 00Group work the 4 cross site teams will discuss their practicals18 30 19 30Bangalore hub dinner19 30 20 4516 00 16 30Heidelberg hub coffee break16 30 17 45Heidelberg hub Practical session 4 continued Interaction mapping plating experiment array species plate and pinTrainers Matthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg Germany17 45 19 15Heidelberg hub Pizza dinner19 15Heidelberg hub Bus from EMBL to the ISG Hotel Day 3 Tuesday 15 October 2024 TimeEurope BerlinSpeakerTimeIndia BangloreZoom link for the day shared in eCampusBangalore hub Overview of the day by Rajalakshmi Srinivasan Institute of Bioinformatics and Applied Biotechnology India09 00 09 1516S analysis of kefir communities using Nanopore sequencing technologyBangalore hub Practical session 2 DNA Extraction Normalization QuantificationTrainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UKRajalakshmi Srinivasan Institute for Stem Cell Science and Regenerative Medicine IndiaWith flexible coffee break during session09 15 12 4508 40Heidelberg hub Bus from ISG Hotel to EMBL09 00 09 15Heidelberg hub overview of the dayMatthias Gross EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg Germany09 15 12 4516S analysis of kefir communities using Nanopore sequencing technologyHeidelberg hub Practical session 2 DNA Extraction Normalization QuantificationTrainers Matthias Gross EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyBangalore hub lunch12 45 13 45Bangalore hub Practical sessions 2 16S analysisTrainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UKRajalakshmi Srinivasan Institute for Stem Cell Science and Regenerative Medicine IndiaSequencing facility led by Dr Awadhesh PanditMetabolomics LC MS Trainers Ganesh Muthu Institute for Stem Cell Science and Regenerative Medicine IndiaSreesa Sreedharan Institute for Stem Cell Science and Regenerative Medicine India13 45 15 45Bangalore hub Coffee break15 45 16 0012 45 13 45Heidelberg hub Lunch breakBangalore hub Practical sessions 2 16S analysisTrainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UKRajalakshmi Srinivasan Institute for StemCell Science and Regenerative Medicine IndiaPractical session 3 Metabolomics LC MS Trainers Ganesh Muthu Institute for Stem Cell Science and Regenerative Medicine IndiaSreesa Sreedharan Institute for Stem Cell Science and Regenerative Medicine India16 00 17 3013 45 14 45Heidelberg hub Practical session 4 continued Interaction mapping plating experiment image analysisMatthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg GermanyWith flexible coffee break during session14 45 16 45Heidelberg hub Practical sessions 2 3 16S analysis GeneCore tourTrainers Jan Provaznik EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyMetabolomics sample extraction derivatization GCMS injection Trainers Denise Selegato EMBL Heidelberg GermanyMaria Zimmermann EMBL Heidelberg GermanyBangalore hub free time17 30 19 00Bangalore hub dinner19 00 20 30Bangalore hub end of Day 320 3016 45 17 00Heidelberg hub coffee break17 00 19 00Heidelberg hubPractical sessions 2 3 16S analysis GeneCore tourTrainers Jan Provaznik EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyMetabolomics sample extraction derivatization GCMS injection Trainers Denise Selegato EMBL Heidelberg GermanyMaria Zimmermann EMBL Heidelberg GermanyBangalore hub dinner followed by networking and drinks18 00 19 3019 00 20 00Heidelberg hub vegetarian dinner followed by networking and drinks20 00Heidelberg hub Bus from EMBL to the ISG Hotel Day 4 Wednesday 16 October 2024 TimeEurope BerlinSpeakerTimeIndia BangloreZoom link for the day shared in eCampusBangalore hub Outing including hike07 00 12 00Bangalore hub Lunch12 00 13 0009 15Heidelberg hub Bus from ISG Hotel to EMBL09 25 09 30Heidelberg hub Overview of the dayMaria Zimmermann EMBL Heidelberg Germany09 30 10 15Lecture 4 Probing interactions in cell populations with metabolomicsSunil Laxman Institute for Stem Cell Biology and Regenerative Medicine India30 minute talk following by 15 minute discussion13 00 13 4510 15 11 00Lecture 5 Experimentally dissecting metabolic interactions within microbial communitiesChristian Kost University of Osnabr ck Germany30 minute talk following by 15 minute discussion13 45 14 3011 00 11 30Heidelberg and Bangalore hubs connected via Zoom and continue discussionsWith flexible coffee break14 30 15 0011 30 12 15Lecture 6 Investigating structure and ecology of microbial communities withmetagenomics taxonomic profilingGeorg Zeller EMBL Heidelberg Germany remote lecture 30 minute talk following by 15 minute discussion15 00 15 4512 15 13 00Heidelberg hub Lunch13 00 13 15Heidelberg hub group photo meet at ATC entrance Bangalore hub Coffee break15 45 16 00Bangalore hub Practical session 4 continued Interaction mapping plating experiment image acquistionTrainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UK16 00 16 4513 15 14 00Lecture 7 Towards understanding microbial community dynamics Developing model systems in foodEmily Putnam Middlebury College USA remote talk 30 minute talk following by 15 minute discussion16 45 17 3014 00 15 30Computational Practical 5 16S data analysisMain trainers Nitish Malhotra National Center For Biological Sciences IndiaZachariah Henseler EMBL Heidelberg GermanyBangalore trainers Akshara Dubey National Center For Biological Sciences IndiaGanesh Muthu Institute for Stem Cell Science and Regenerative Medicine IndiaHeidelberg trainers Bartosz Jan Bartmanski EMBL Heidelberg GermanyFabian Springer EMBL Heidelberg GermanyMaria Zimmermann EMBL Heidelberg Germany17 30 19 0015 30 16 00Heidelberg hub Coffee breakBangalore hub Dinner followed by casual networking19 00 20 3016 00 18 00Heidelberg hub Computational Practical 6 Metabolomics data analysisZachariah Henseler EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg GermanyMaria Zimmerman EMBL Heidelberg Germany 18 00Heidelberg hub bus to ISG bus will stop briefly then return to EMBL 18 20Heidelberg hub EMBL to downtown18 40 19 40Heidelberg Old Town city tour20 00 22 00Heidelberg downtown dinner and networking Day 5 Thursday 17 October 2024 TimeEurope BerlinSpeakerTimeIndia BangaloreZoom link for the day shared in eCampusBangalore hub Overview of the dayGanesh Muthu Institute for Stem Cell Science and Regenerative Medicine India08 45 09 00Bangalore hub Computational practical 6 Metabolomics data analysisTrainers Sunil Laxman Institute for Stem Cell Biology and Regenerative Medicine Bangalore IndiaNitish Malhotra National Centre for Biological Sciences IndiaSreesa Sreedharan Institute for Stem Cell Science and Regenerative Medicine India09 00 11 00Bangalore hub Group photo and coffee break11 00 11 15Bangalore hub Treasure hunt11 15 12 00Bangalore hub Lunch12 00 13 0009 00Heidelberg hub Bus from ISG Hotel to EMBL09 15 09 30Heidelberg hub Overview of the dayKiran Patil University of Cambridge UK Maria Zimmermann EMBL Heidelberg Germany09 30 10 15Lecture 8 Chemical biology of microbesAmrita Hazra Indian Institute of Science Education and Research Pune30 minute talk following by 15 minute discussion13 00 13 4510 15 11 00Lecture 9 Modelling microbial community interactionsKiran Patil University of Cambridge UK30 minute talk following by 15 minute discussion13 45 14 3011 00 11 30Moderated discussion on responsibleconduct of research in computational analysis whole group discussion followed by breakout groups Computational trainers and Renato Alves EMBL Heideberg Germany14 30 15 0011 30 13 00Computational Practical 7 Metabolic modelling of community interactionsMain trainers Kiran Patil University of Cambridge UKFrancisco Zorrilla University of Cambridge UKZachariah Henseler EMBL Heidelberg GermanyMaria Zimmermann EMBL Heidelberg Germany15 00 16 3013 00 14 00Heidelberg hub LunchBangalore coffee break16 30 16 45Bangalore hub Practical Interaction mapping plating experiment image analysisTrainers Simran Aulakh University of Cambridge UKSonja Blasche University of Cambridge UK16 45 17 3014 00 15 45Computational Practical 7 Metabolic modelling of community interactionsMain trainers Kiran Patil Universtiy of Cambridge UKZachariah Henseler EMBL Heidelberg GermanyFrancisco Zorrilla Universtiy of Cambridge UKNitish Malhotra National Center for Biological Studies IndiaMaria Zimmermann EMBL Heidelberg Germany17 30 19 1515 45 16 15Coffee break and chance to interact cross sites19 15 19 4516 15 17 00Heidelberg hub Practical session 4 Interaction mapping plating experiment image aquisitionMatthias Gross EMBL Heidelberg GermanyDenise Selegato EMBL Heidelberg Germany17 00 18 00Heidelberg hub EMBL campus treasure huntBangalore hub Dinner followed by networkingEnd of Day 519 45 21 1518 00 19 00Heidelberg hub Tapas dinner followed by networking19 00Heidelberg hub Bus from EMBL to the ISG HotelEnd of Day 5 Day 6 Friday 18 October 2024 TimeEurope BerlinSpeakerTimeIndia BangaloreZoom link for the day shared in eCampusBangalore hub Core facility tours09 00 10 15Bangalore hub Coffee break10 15 10 30Bangalore hub Practical presentation preparation time10 30 11 3007 50Heidelberg hub Bus from ISG Hotel to EMBL08 00 09 00Cross site preparation time in teams for practical presentations11 30 12 30Bangalore hub Lunch break12 30 13 3009 00 10 00Heidelberg hub Group work and facility tours continued10 00 11 45Cross site team presentations10 minute presentation 10 minute discussion per team13 30 15 1511 45 12 45Bangalore hub coffee breakHeidelberg hub LunchOpportunity to network on specific topics15 15 16 1512 45 13 45Lecture 10 Modeling microbial ecosystems in time and spaceKatharine Coyte remote talk 16 15 17 1513 45 14 30Discussion round on responsible conduct of researchAll trainers and organisersRenato Alves EMBL Heidelberg Germany pre course reading material from Renatao will be made available in eCampus Sabuj Bhattacharya Institute for Stem Cell Biology and Regenerative Medicine Bangalore India17 15 18 0014 30 15 00Joint summary take home messages principles of responsible conduct of research and closing remarks treasure hunt challenge results18 00 18 30Bangalore hub Course dinner impressions shared via eCampus End of course18 30 20 0015 15Heidelberg hub Bus from EMBL to downtown Heidelberg for free time in the city18 30Heidelberg hub Bus from downtown Neckarmuenzplatz to ISG Hotel19 00Heidelberg hub Final evening dinner at the ISG HotelEnd of course Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation EMBL Heidelbergsite Germany Bangalore Life ScienceCluster campus site India Academia 500 150PhD Student 500 150Industry 500 150 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel EMBL Heidelberg site participantsAccommodation for participants attending the course at EMBL Heidelberg has been pre booked for you at the ISG Hotel for the default dates of 13 October to 19 October 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG but that you will be required to pay an additional cost of 24 EUR per night for a single room This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants for the EMBL Heidelberg site stay at the ISG Hotel which is the dedicated hotel for the course Bangalore Life Science Cluster site participants Accommodation for participants attending the course at the Bangalore Life Science Cluster campus site has been pre booked at the hotel on campus for the default dates of 13 to 19 October 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts Any additional nights need to be booked and paid for by you We recommend that all course participants for the BLiSC campus site stay at the campus hotel which is the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport EMBL Heidelberg site participantsShuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Bangalore Life Science Cluster site participantsThe accommodation on campus is within walking distance of the buildings where the course will take place Further details EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany Bangalore Life Science Cluster Campus Bellary Road Bangalore 560065 Karnataka IndiaFor further information on getting to EMBL Heidelberg visit our Travel Information page Further information on getting to Bangalore Life Science Cluster Campus will be provided to selected course participants For EMBL Heidelberg only for enquiries about accommodation and local transportation please refer to the FAQ page On site information The below information applies to the EMBL Heidelberg hub Information about on site facilities at BLiSC will be shared with participants upon arrival Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Course partners Course sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Sunil Laxman, Kiran Patil, Elisabeth Zielonka, Maria Zimmermann-Kogadeeva

10 October 2024

A guide to UniProt for students

Description UniProt provides the scientific community with a comprehensive high quality and freely accessible resource of protein sequence and functional information This webinar will guide you through ways in which students and researchers at all career stages may take a structured approach to access the data in the UniProtKB and Proteomes sections of the UniProt protein function database The webinar will discuss the types of data that can be accessed and using sequence analysis tools how this data can be analysed to answer biological questions We will demonstrate how to find the function of a protein how the protein components of a pathway may be identified features of proteins of interest can be compared similar sections of sequence can be sought in other species and how whole data sets containing all the proteins expressed in an organism can be obtained By accessing sequence structural and functional data through UniProt we want researchers to be part of data s biological journey and support further work and adventures along the way...

9 October 2024

Visualising integrated single cell and spatial transcriptomics datasets

Description Spatial transcriptomics is a cutting edge field that has revolutionised our understanding of biological systems by integrating spatial information with transcriptomics technologies WebAtlas is a data pipeline and visualisation platform for integrated single cell and spatial transcriptomic data This webinar will introduce the WebAtlas platform and its collaboration with the BioImage Archive which is a free public archive for the biological imaging data particularly showcasing the importance of open FAIR data and cloud compatible scalable open data formats...

8 October - 11 October 2024

Molecular mechanisms in evolution and ecology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia Kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Dramatic advances in omics technologies and genetic engineering now enable us to tackle one of biology s most fascinating problems how evolution works in life s communities and ecosystems Gaining mechanistic insights requires bringing together multiple disciplines and viewpoints The focus of this workshop series is on interspecies and cell environment interactions across living organisms with a special focus on bacteria microbial eukaryotes and viruses The workshop series aims to highlight the latest technological advances amplify scientific and societal focus on biodiversity and showcase studies on the vital role of microbes in planetary ecosystems The 2024 meeting will bring together researchers from a wide range of fields and organismal systems that aim to gain mechanistic insights on major outstanding ecological and evolutionary questions e g how organisms interact and assemble into communities how genotypic variation transforms into phenotypic variation or that develop novel experimental and or computational approaches for doing so The meeting will foster dialogue between researchers from different backgrounds that work on diverse ecological systems to catalyze new innovative ideas and aid the career advancement of young researchers Session topics In the wild The genotype phenotype map Coevolution across trophic levels Assembly and evolution of communities Innovative integrative approaches for ecology and evolution What past participants say about the conference An incredibly interesting and well organised event not only from the scientific side but also on the technical part As expected from other editions of the meeting the science was amazing and very variegated Kudos for the organisation and for the unusually high number of young speakers Irene Stefanini University of Turin Italy One of my favourite meetings with a real community feeling I ve started collaborations and made great friends here Rike Stelkens Population Genetics Stockholm University Sweden A great conference and academic environment networking opportunities are limitless Jose Antonio Urban Aragon International Laboratory for Human Genome Research National Autonomous University of Mexico LIIGH UNAM Mexico This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Keynote speakers Harmit Malik Howard Hughes Medical Institute Fred Hutchinson Cancer Center USA Speakers Aude Bernheim Institut Pasteur France Jesse Bloom Howard Hughes Medical Institute Fred Hutchinson Cancer Center USA Virtual speaker Susana Coelho Max Planck Institute for Biology T bingen Germany Vaughn Cooper University of Pittsburgh USA Kat Coyte University of Manchester UK Juan Diaz Colunga Institute of Functional Biology Genomics CSIC University of Salamanca Spain Jordi van Gestel EMBL Heidelberg Germany Paula Goncalves Nova School of Science and Technology Portugal Georg Hochberg Max Planck Institute for Terrestrial Microbiology Germany Nicole King Howard Hughes Medical Institute University of California Berkeley USA Virtual speaker Irene Newton Indiana University USA Clarissa Nobile University of California Merced USA Kiran Patil University of Cambridge UK Markus Ralser Charit University Medicine Germany Antonis Rokas Vanderbilt University USA Hinrich Schulenburg Kiel University Germany Julia Schwartzman University of Southern California USA Sarah Teichmann Cambridge Stem Cell Institute UK Virtual speaker Scientific organisers Gilles Fischer Sorbonne University France Jordi van Gestel EMBL Heidelberg Germany Kimberly Kline University of Geneva Switzerland Sara Mitri University of Lausanne Switzerland Antonis Rokas Vanderbilt University USA Conference organiser Aline Schnieder EMBL Heidelberg Germany Programme Are you on social media Post using EMBOEvoEco and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 8 October 2024 Time Europe Berlin Speaker14 30 16 00Registration and coffee16 00 16 15Opening remarks by scientific organisers16 15 17 15Keynote lecture Fitness landscapes in host virus interactionsHarmit Malik Howard Hughes Medical Institute and Fred Hutchinson Cancer Center USASession 1 In the wildSession chair Antonis Rokas Vanderbilt University USA17 15 17 45Tumultuous evolution of a floral yeast clade impact of gene loss and HGT on metabolic adaptationPaula Goncalves Nova School of Science and Technology PortugalNot available on demand17 45 18 15Choanoflagellates introverted or just repressed Nicole King Howard Hughes Medical Institute University of California Berkeley USA virtual speaker 18 15 18 35Mass lysis of bacterial predators drives the enrichment of antibiotic resistance in soil microbial communities Samay Pande Indian Institute of Science IndiaNot available on demand18 35 18 55Gene conversion drives natural product diversification in soil bacteria Aleksandra Nivina University of Zurich Switzerland18 55 20 00Dinner in EMBL Canteen20 00 21 00Pub quiz in EMBL Canteen21 00 22 00Poster session sneak peek with drinks Day 2 Wednesday 9 October 2024 Time Europe Berlin SpeakerSession 1 In the wildSession chair Antonis Rokas Vanderbilt University USA09 00 09 30Evolution in a complex world predator prey interactions in the soil Jordi van Gestel EMBL Heidelberg GermanyNot available on demand09 30 10 00Evolution of reproductive strategies lessons from seaweeds and their virusSusana Coelho Max Planck Institute for Biology T bingen GermanyNot available on demand10 00 10 20Environmental and genetic control of Saccharomyces yeasts mating strategies Chiara Vischioni Centre National de la Recherche Scientifique CNRS IRCAN France10 20 11 00Coffee break and meet the speakers11 00 11 20The life cycle of natural budding yeast polyploidsCintia G mez Mu oz Sorbonne Universit France11 20 11 40Unraveling the molecular mechanisms behind multicellularity evolution in brown algae virus interactionsLiping Wang Max Planck Institute for Biology T bingen GermanySession 2 The genotype phenotype mapSession chair Gilles Fischer Sorbonne University France11 40 12 10Evolution of the genotype phenotype map across an entire subphylum of yeastsAntonis Rokas Vanderbilt University USA12 10 12 30Robust genetic codes enhance protein evolvability Hana Rozhonov Charles University Czech Republic12 30 13 30Lunch and meet the speakers13 30 14 10Flash talks by poster presenters odd numbers 43 Fabrizio Angaroni 63 Anna Czerwinski 83 Chlo Haberkorn 93 Tera Levin 99 Paul Mathias Jansen 109 Lea Kloss 117 Ming Liu 119 Tomoya Maeda 123 Nora Martin 133 Ambre Noly 145 Zsuzsa Sarkadi 149 Andreas Sichert 153 Junya Sunagawa 161 Isabella Tomanek 163 Nikolaos Vakirlis 169 Andriy Volkov14 10 16 00Poster session 1 odd numbers Poster listing16 00 17 00Meet the editorsSerena Bradde PRX Life USAVera Domingues Nature Ecology Evolution UKAndrea Du Toit Nature Reviews Microbiology UKFrancois Mayer Nature Microbiology GermanyStephanie McClelland Springer Nature GermanyYehu Moran EMBO Press GermanyRoland Roberts PLoS Biology UK17 00 17 30Ecological dynamics of bacterial cell collectivesJulia Schwartzman University of Southern California USANot available on demand17 30 18 00Highly parallel evolution in a recombination driven molecular arms raceGeorg Hochberg Max Planck Institute for Terrestrial Microbiology Germany18 00 18 30Interpreting the evolution of SARS CoV 2Jesse Bloom Howard Hughes Medical Institute Fred Hutchinson Cancer Center virtual speaker 18 30 18 50From infection to protection how prophages contribute to antiviral defence in Pseudomonas aeruginosa Anna Olina University of Exeter United Kingdom18 50 19 10Quantitative analysis of repeatability and contingency in antibiotic resistance evolution Gabriela Petrungaro University of Cologne Germany19 10 20 40Dinner in EMBL Canteen20 40 22 00After dinner drinks in ATC Foyer Day 3 Thursday 10 October 2024 Time Europe Berlin SpeakerSession 3 Coevolution across trophic levelsSession chair Jordi van Gestel EMBL Heidelberg Germany09 00 09 30Mobile genetic elements shape the honey bee microbial communityIrene Newton Indiana University USA09 30 09 50Recurrent hybridization to introgression cycles in a yeast populationEugenio Mancera Centro de Investigaci n y de Estudios Avanzados del Instituto Politecnico Nacional MexicoNot available on demand09 50 10 10Sedentary chromosomal integrons as biobanks of bacterial anti phage defence systems Eloi Littner Institut Pasteur France10 10 10 30Retracing the horizontal transfer of a novel innate immune factor in Drosophila Rebecca Tarnopol University of California Berkeley USA10 30 11 00Coffee break and meet the speakers11 00 11 30Evolution of anti viral immunity across domains of lifeAude Bernheim Institut Pasteur France11 30 12 00Evolution of C elegans microbe interactionsHinrich Schulenburg Kiel University Germany12 00 12 20Experimental evolution of evolvability Michael Barnett Max Planck Institute for Evolutionary Biology Germany12 20 13 30Lunch and meet the speakers13 30 14 10Flash talks by poster presenters even numbers 42 Danielle Adekunle 48 Stefan Bassler 70 Alice Dufour 72 Sarah Frail 90 Mathieu H nault 102 Jean Baptiste Boule 106 Dan Kehila 116 Jun Liu 132 Mariana Natalino 134 Francisco Cubillos 142 Lucas Santana Souza 148 Ton Sharoni 150 Luca Soldini 152 Aleksandar Stanojkovic 158 Nicol Tellini 160 AmirAli Toghani 162 Vjaceslav Tretjacenko 166 Petra Vande Zande14 10 16 00Poster session 2 even numbers Poster listingFree eveningOptional Castle tour limited space available sign up on site Day 4 Friday 11 October 2024 Time Europe Berlin SpeakerSession 4 Assembly and evolution of communitiesSession chair Sara Mitri University of Lausanne Switzerland09 00 09 30Understanding and predicting microbiome dynamics Kat Coyte University of Manchester UK09 30 09 50Divergence in gene expression plasticity is driven by a blend of trans regulatory mechanismsAnna Redhuis University of Michigan USA09 50 10 10The link between amoeba predation virulence and multicellularity in yeast Helen Murphy William Mary USA10 10 10 50Coffee break and meet the speakers10 50 11 20Candida biofilms importance regulation and evolutionClarissa Nobile University of California Merced USA11 20 11 50Evolutionary genetics of opportunistic bacteria growing on surfaces or in hostsVaughn Cooper University of Pittsburgh USA11 50 12 10Relationship between bacterial interspecies interactions and carbon source diversity Hiroki Ono The University of Tokyo Japan12 10 12 30How does the environment shape bacterial interactions Josephine Solowiej Wedderburn Ume University Sweden12 30 14 00Lunch and meet the speakers14 00 14 30Global ecological interactions enable prediction of community level functionsJuan D az Colunga CSIC University of Salamanca Spain SpainSession 5 Innovative integrative approaches for ecology and evolutionSession chair Kimberly Kline University of Geneva Switzerland14 30 15 00The role of metabolism in shaping enzyme structures over 400 Million years of evolutionMarkus Ralser Charit University Medicine Germany15 00 15 20Genome wide sweeps create fundamental ecological units in the human gut microbiome Xiaoqian Yu University of Vienna Austria15 20 16 00Coffee break and meet the speakers16 00 16 20Understanding the functional range of antiphage systems in Pseudomonas aeruginosaAleksei Agapov University of Exeter UK16 20 16 50What chemicals do to our bugs Kiran Patil University of Cambridge UKNot available on demand16 50 17 10Genetic and ecological determinants of bacterial pathogen success during plant infection Julien Luneau University of Lausanne Switzerland17 10 17 40Coffee break and meet the speakers17 40 18 10Mapping the human body one cell at a timeSarah Teichmann Cambridge Stem Cell Institute UK virtual speaker 18 10 18 30From molecules to communities predicting the emergent properties of spatially structured microbial systems Simon van Vliet University Basel Switzerland18 30 18 50The role of mutational buffering genes in shaping the phenotypic effects of de novo mutations Mohammed Tawfeeq VIB KU Leuven Center for Microbiology Belgium18 50 19 00Closing remarks and poster prizes19 00 20 30Dinner in EMBL Canteen20 30 23 30Party in the ATC Foyer with band Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 550On site PhD Student 350On site Industry 750On site Journal Editors 300Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Aline Schnieder for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 10 September 2024 in some cases at special rates Please email the hotel directly quoting the booking code EAE24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the conference shuttle bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop Rohrbacher Str 22 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin Vegetarier VegetarierinIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners ChemBioChem a Wiley Journal EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Journal of Molecular Biology an Elsevier journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media Kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Gilles Fischer, Jordi van Gestel, Kimberley Kline, Sara Mitri, Antonis Rokas

2 October 2024

Building a spatial transcriptomics platform

Description The Light Imaging Facility LIF at EMBL Rome offers training and support to users for experimental design tissue sample processing imaging data acquisition and image analysis Importantly the LIF is also involved in technology development ensuring access to innovative sample and imaging techniques such as spatial transcriptomics and expansion microscopy This webinar will demonstrate how we built a service platform for spatial transcriptomics using our in house developed methods...

1 October - 5 October 2024

Computational Biology Training in Hematology 2024, Module 2

Description Computational Biology Training in Hematology CBTH provides early career researchers aiming to specialize in computational and quantitative biology aspects of hematology with a unique year long training and mentoring experience by top tier faculty CBTH is a joint effort of the European Hematology Association EHA and the European Molecular Biology Laboratory European Bioinformatics Institute EMBL EBI that aims to support the development of quantitative skills for hematology researchers through training and mentoring in computational biology...

Barbara Etzi

30 September - 3 October 2024

Defining and defeating metastasis

Description OverviewSpeakersProgrammePractical informationPre conference workshopSponsorsAboutMedia kit Overview Late registration is still available Please reach out to events embl org to request it This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview In its second edition this symposium will cover emerging key concepts of latent metastasis and dissemination of tumour cells including evolution and genetic diversity of metastasis circulating tumour cells stemness dormancy and stromal reprogramming transcriptional and epigenetic control motility and invasive signalling metastatic heterogeneity EMT and plasticity immune evasion and metabolic adaptations The meeting will provide a unique interdisciplinary exchange on current approaches and future collaborations on metastasis and its therapeutic challenges Metastasis research is a nexus for several of the most exciting areas and technical developments of current cancer biology and translational molecular medicine High resolution intravital imaging single cell sequencing and integrated genomics approaches innovative tissue modelling and co culture systems for disease screening and patient stratification all have enormous implications for our basic understanding of the mechanisms of this deadly disease and hold great promises for progress in its successful treatment This cutting edge meeting is aimed at a broad spectrum of life scientists and clinicians working in cancer immunology cell and molecular biology Session topics Metastasis initiating cells circulating tumour cells Motility and invasion Transcriptional and epigenetic control of metastasis Metastasis heterogeneity EMT and plasticity Metastasis signalling and latency Metastasis imaging tumour microenvironment and immune evasion What past participants say about the Symposium The Defining and Defeating Metastasis Symposium was probably the best conference I have attended during my PhD Engaging speakers new science and plenty of opportunity to network and socialise all a stone s throw from the centre of beautiful Heidelberg Hoping for a repeat event in the future Emma Colliver Francis Crick Institute UK As a PhD student in breast cancer research the symposium in Defining and defeating metastasis was amazing The speakers were excellent and I left the conference with a lot of learning from established and new researchers The EMBL Heidelberg venue was quiet and provided a good backdrop to discuss current research in metastasis Catering was great with many vegan vegetarian options as well The conference provided a lot of opportunities to network with other fellow students but also with established researchers Jomar Gustave Roussy Universite Paris Saclay France Defining and Defeating Metastasis was the most engaging and stimulating conference I ever attended EMBL location is amazing and the conference was perfectly organised Mila Gugnoni Laboratory of Translational Research AUSL IRCCS Reggio Emilia Italy The level of the science presented was great did a marvellous work covering broad and key aspects of metastasis development Beatriz P rez Garvan MRI Australia virtual participant Speakers Keynote speakers Mikala Egeblad Johns Hopkins University USA Sean Morrison Children s Research Institute USA Speakers Julio Aguirre Ghiso Albert Einstein College of Medicine USA Salvador Aznar Benitah Institute for Research in Biomedicine Spain C dric Blanpain Universit Libre de Bruxelles Belgium Kevin Cheung Fred Hutchinson Cancer Center USA Caroline Dive University of Manchester UK Michaela Frye DKFZ Germany Karuna Ganesh Memorial Sloan Kettering Cancer Center USA Trevor Graham The Institute of Cancer Research UK Rene Jackstadt HI STEM and DKFZ Germany Ilaria Malanchi The Francis Crick Institute UK Belinda Parker Peter MacCallum Cancer Centre Australia Victoria Sanz Moreno The Institute of Cancer Research UK Marisol Soengas Spanish National Cancer Research Center CNIO Spain Samra Turajlic The Francis Crick Institute UK Jacco van Rheenen The Netherlands Cancer Institute The Netherlands Scientific organisers Eduard Batlle Institute for Research in Biomedicine Spain Johanna Joyce University of Lausanne Switzerland Daniel Klimmeck The EMBO Journal Germany Joan Massagu Memorial Sloan Kettering Cancer Center USA Samra Turajlic The Francis Crick Institute UK Conference organiser Inna B sselmann EMBL Heidelberg Germany Programme Are you on social media Post using EESMetastasis and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 30 September TimeSpeaker11 45 13 30Registration and light refreshments12 15 13 15Pre conference workshop with GemPharmatec13 30 13 45Opening remarks by Joan Massagu 13 45 14 30 Keynote lecture Human osteosarcoma metastasis is limited by oxidative stressSean Morrison UT Southwestern Medical Center USA13 45 17 45Session 1 Chair Marisol Soengas National Cancer Research Center Spain14 30 15 00Age related host mosaicism as a driver of dormant cancer cell awakening in the lungJulio Aguirre Ghiso Albert Einstein College of Medicine USANot available on demand15 00 15 15Zeb1 mediated control of the PUFA MUFA ratio in EMT associated ferroptosis sensitivityNino Bindel FAU Erlangen N rnberg Germany15 15 15 30Aiding and aBETting metastasis Epigenetic driven awakening in ER breast cancerHazel Quinn ISREC EPFL Switzerlandvirtual speaker15 30 16 00Coffee break and meet the speakers16 00 16 30Deciphering and targeting of fetal like stem cells in metastatic colorectal cancerRene Jackstadt German Cancer Research Center DKFZ GermanyNot available on demand16 30 16 45Homopolymer switches mediate adaptive mutability in mismatch repair deficient colorectal cancerSuzanne van der Horst UMC Utrecht The Netherlands16 45 17 00Dual metastasis and tumor inhibitory efficacy of a first in class metastasis initiating cell targeted therapeutic antibodyKelvin Kunchih Tsai Taipei Medical University Taiwan17 00 17 30Impact of emergency granulopoiesis on metastasisIlaria Malanchi The Francis Crick Institute UK17 30 19 00Dinner in EMBL Canteen19 00 21 00Science Pub Quiz after dinner drinksEMBL Canteen Day 2 Tuesday 1 October TimeSpeaker09 00 12 00 Session 2 Chair Sean Morrison UT Southwestern Medical Center USA09 00 09 30Systemic rewiring of dendritic cells in melanoma progression implications for immune checkpoint blockadeMarisol Soengas National Cancer Research Center Spain09 30 09 45Gene expression adaptation of metastasis to their host tissueLuise Nagel University of Cologne Germany09 45 10 00Antagonism between tumors and lymphocytes drives coevolutionary processes throughout metastasisCort Breuer Stanford University United States of America10 00 10 15Intestinal bacteria are trapped alongside the nuclei of colorectal cancer cells survival in a foreign yet safe environment Reinhild Feuerstein University Medical Center Freiburg Germany10 15 10 45Coffee break and meet the speakers10 45 11 00Single molecule Liquid Biopsy Systems for Multiplexed Detection of Epigenetic Modifications and Oncoproteins for Cancer DiagnosticsNoa Furth Weizmann Institute of Science Israel11 00 11 15Role of MYC in liver metastatic pancreatic ductal adenocarcinoma and therapeutic resistanceRosalie Sears Oregon Health and Science University United States of America 11 15 11 45Bringing bone metastases out of hiding for therapeutic targetingBelinda Parker Peter MacCallum Cancer Centre AustraliaNot available on demand11 45 12 00Flash talks session 1 3 min per talk Poster numbers 60 70 72 83 8512 00 13 30Lunch and meet the editors 13 00 13 30Imaging Centre ToursSeparate Registration required please await further information before eventGuided by Timo Zimmermann and Stephanie Alexander13 30 15 00Poster Session 1 odd numbers 15 00 15 30Coffee break and meet the speakers15 30 17 30Session 3 Chair Ilaria Malanchi The Francis Crick Institute UK15 30 16 00Dissecting plasticity during colorectal cancer metastasisKaruna Ganesh Memorial Sloan Kettering Cancer Center USANot available on demand16 00 16 15A senescence like state of tumor cells contributes to tumor aggressiveness and makes them vulnerable to senolysisMathieu Boissan Sorbonne University FranceNot available on demand16 15 16 30Loss of STAG2 leads to EWS FLI1 dependent and independent rewiring of enhancer promoter contacts and contributes to aggressive Ewing sarcomaAna Cuadrado Spanish National Cancer Research Centre Spain16 30 16 45Marking out cancer stem cells that drive gastric tumourigenesis in mice and humansGrace Lim Institute of Molecular and Cell Biology A STAR Singapore16 45 17 15Mechanisms regulating EMT statesC dric Blanpain Universit libre de Bruxelles Belgium17 15 Free evening18 00 19 00Optional guided tour Old town Heidelberg Day 3 Wednesday 2 October TimeSpeaker09 00 12 00Session 4 Chair Mikala Egeblad Johns Hopkins University School of Medicine USA09 00 09 30Systemic impact of metastasis over host metabolismSalvador Benitah Aznar Institute for Research in Biomedicine Barcelona SpainVirtual talk09 30 09 35Beug foundation awardees of 2023 Chair Martin Jechlinger EMBL Heidelberg Germany09 35 10 15Beug metastasis foundation awardees 2023 Ilaria Elia Katholieke Universiteit BelgiumColinda Scheele Katholieke Universiteit BelgiumToni Celi Terrassa Research Institute Hospital del Mar IMIM SpainIoanna Keklikoglou University of Crete Greece10 15 10 45 Coffee break and meet the speakers10 45 11 00Utilising gene editing technology to uncover novel immunotherapies for targeting bone metastases in breast cancerThomas Chadwick Peter MacCallum Cancer Centre Australia11 00 11 15Role of Epsin 3 in breast cancer tumorigenesis and metastasisAmir Fardin European Institute of Oncology Italy11 15 11 45Cell and tissue state transitions regulating collective metastasisKevin Cheung Fred Hutchinson Cancer Center USANot available on demand11 45 12 00Flash talks session 2 3 min per talk Poster numbers 82 94 96 98 10212 00 13 30Group photo Lunch 12 30 13 30Career discussion session in Courtyard room Charting Your Path Insights into Successful Careers in Fundamental and Translational Cancer Research Presenters Johanna Joyce University of Lausanne Switzerland Samra Turajlic The Francis Crick Institute UK13 30 16 15 Session 5 Chair C dric Blanpain Universit libre de Bruxelles Belgium13 30 14 00Filming the fate of cells carrying mutations in cancer driver genesJacco van Rheenen The Netherlands Cancer Institute The NetherlandsNot available on demand14 00 14 15Dynamic analysis of individual cells from metastasizing populations with holographic incoherent light source quantitative phase imagingDaniel Zicha CEITEC VUT Brno Czech Republic14 15 14 30Breast cancer remodels the bone marrow lymphoid microenvironment to favor bone metastasisAna Teijeiro National Institute of Allergy and Infectious Diseases NIAID USA14 30 15 00The role of genome instability and immune evasion in metastasisSamra Turajlic The Francis Crick Institute UK15 00 15 30Coffee break and meet the speakers15 30 15 45Two distinct epithelial to mesenchymal transition programmes control invasion and inflammation in segregated tumour cell populationsKhalil Kass Youssef Instituto de Neurociencias de Alicante CSIC UMH Spain15 45 16 00Understanding the molecular mechanism behind tandem motifs induced CtBP polymerization in pre clinical and clinical modelsNishit Goradia University Medical Center Hamburg Eppendorf Germany16 00 16 15Sybodies to inhibit the metastasis promoting activity of Cofilin 1 by replacing the protein from F actinSabine Windhorst University Medical Center Hamburg Eppendorf Germany16 15 16 45Small Cell Lung Cancer MetastasisCaroline Dive University of Manchester UKNot available on demand16 45 18 15Poster Session 2 even numbers 18 15 20 15Conference dinner in EMBL Canteen20 15 23 45 Party with DJ Jenz in ATC Rooftop Lounge Day 4 Thursday 3 October Time Speaker09 00 12 30 Session 6Chair Jacco van Rheenen Netherlands Cancer Institute The Netherlands09 00 09 30 Metastatic evolution of colorectal cancerTrevor Graham Institute of Cancer Research UK09 30 09 45Tumor microenvironment induced FOXM1 regulates ovarian cancer stemnessChiara Battistini European Institute of Oncology IRCCS Italy09 45 10 00Emerin mis localization during chromatin bridge resolution can drive prostate cancer cell invasiveness in collagen rich microenvironmentPaulina Nastaly Medical University of Gdansk Poland 10 00 10 15Mitochondrial J protein JC15 effected metabolic rewiring induces aggressive tumour phenotypes in breast cancer cellsPriyadarshika Pradhan Banaras Hindu University Indiavirtual speaker10 15 10 45Coffee break and meet the speakers10 45 11 15Targeting RNA modifications in cancerMichaela Frye DKFZ Germany11 15 11 45Biomechanical hallmarks and vulnerabilities of metastatic cancer cellsVictoria Sanz Moreno The Institute of Cancer Research ICR UK11 45 12 30Keynote lecture NETworking with cancer The bidirectional interplay between cancer and neutrophil extracellular trapsMikala Egeblad Johns Hopkins University School of Medicine USA12 30 13 00Closing remarks and Poster prizes by the Scientific Organizers13 00 13 30Packed lunch and departure13 30Bus to airport tickets available at registration desk Conference shuttle to the Main station and hotels Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Inna Boesselmann for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 2 September 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 10 to confirm the exact price of the room B B HotelStaycity Aparthotel HeidelbergHotel ibis HeidelbergSteffi s Hostel HeidelbergISG Hotel Hilton HeidelbergMeininger HeidelbergPremier Inn Heidelberg City Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the conference shuttle bus schedule here The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche Hilton Hotel Kurf rsten Anlage 1 ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event You can find the final bus schedule here Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Pre conference workshop For on site participants only This industry webinar will be hosted by our sponsor GemPharmatech Co Ltd before the EMBO EMBL Symposium Defining and defeating metastasis on Monday 30 September 2024 12 15 13 15 Participation in this workshop is free of charge for registered on site conference attendees The workshop room will be announced on site ABSTRACT Genetically modified mouse models for the investigation of disease and protein function mechanisms Hong Yu WANGGemPharmatech Co Ltd Nanjing China The mouse as a model organism plays a crucial role in elucidating disease mechanisms and identifying potential drug targets With the rapid advancement of CRISPR Cas based genome modification techniques in mice we launched the Knock Out All Project KOAP in 2018 to induce mutations in all protein coding genes within the mouse genome using both conventional and conditional floxed methods After five years of effort we have achieved approximately 50 completion of the entire project resulting in the establishment of the largest collection of genetically modified mouse strains As of June 2024 we have generated and prepared for distribution a total of 10 881 knockout KO strains and 9 874 conditional knockout flox cKO strains In order to facilitate engraftment of human cells tissues and organs without rejection by the functional immune system present in mice various immune compromised strains have been developed To this end we directly disrupted Prdkc and Il2rg genes in NOD mice to create an enhanced engraftment model known as NCG with improved acceptance of human immune cells and tissues However the NCG mouse models have limitations when it comes to supporting differentiation of immune cell populations other than T cells such as myeloid cells and NK cells To address this limitation we are developing the next generation of NCG models with specific enhancements such as expression of human cytokines and HLA molecules along with increased engraftment capacity for human cells These new models will be more suitable for studying differentiation of immune cell types and will be made available to academic researchers The enhanced engraftment capability for human immune cells has been validated in our laboratory and relevant data can be downloaded from our website when searching for specific strains Sponsors Silver sponsor Event sponsors Media partners Advanced Biology a Wiley Journal Advanced Genetics a Wiley Journal BioEssays a Wiley Journal ChemBioChem a Wiley Journal Disease Models Mechanisms The Company of Biologists Journal EMBO Molecular Medicine an EMBO Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Molecular Oncology a FEBS journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 729 90...

Eduard Batlle, Johanna Joyce, Daniel Klimmeck, Joan Massagué, Samra Turajlic

25 September 2024

Developing data infrastructures and analytical systems for spatial omics

Description Spatially resolved omics technologies are revolutionising our understanding of biological tissues by introducing new ways to characterise tissue architectures and identify cell cell interactions However handling spatial omics datasets remains challenging due to the large heterogeneity of profiling technologies resulting in fragmented file formats and the plethora of arbitrary ways to store analysis results further exacerbates this fragmentation Additionally the data volume often exceeds the memory capacity of standard computing environments These challenges make it difficult to construct scalable interoperable workflows and to share them reproducibly with the scientific community In this webinar we will present a software solution the SpatialData framework that we developed in Python to address these data representation challenges Specifically we will demonstrate how our software infrastructure can be used to Represent data from the most commonly available assays in a unified wayManipulate query and compute statistics on the dataVisualise and annotate the data interactivelyPrepare the data for sharing to maximise interoperability...

23 September - 27 September 2024

Metagenomics bioinformatics at MGnify

Description Learn about the tools processes and analysis approaches used in the field of genome resolved metagenomics This course will cover the use of publicly available resources to manage share analyse and interpret metagenomics data focussing primarily on assembly based approaches The delivered content will involve participants learning via live lectures and presentations followed by live Q As with the trainers Practical experience will be developed in group activities and in computational exercises run using containerised tools on our training infrastructure...

Meredith Willmott

23 September - 27 September 2024

Single-cell RNA-seq analysis with Python

Description This course covers the analysis of single cell RNA seq data using Python and command line tools Participants will be guided through droplet based single cell RNA seq analysis pipelines from raw reads to cell clusters Furthermore you ll learn how to generate common plots for visualisation and analysis of gene expression data including TSNE UMAP and violin plots Please note that participants will not analyse their own data as part of the course There will however be ample opportunity to discuss their research and ideas with other course participants and trainers Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through trainer led computational exercises and group activities Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 00 17 30 BST each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Juanita Riveros

18 September 2024

Inferring cell-cell communication through spatial transcriptomics data

Description By leveraging spatial coordinate information with expression levels of ligands and target receptors computational methods developed for analysing spatial transcriptomics data can predict biologically relevant signalling activity This activity is important for healthy tissue function and disease pathogenesis This webinar will present an overview of published computational approaches and databases used to infer spatially confined secreted and or cell contact mediated signalling with a particular focus on data generated from the 10X Genomics Visium assay Furthermore methods to link inferred cell signalling with specific cell types and downstream pathway activation will be briefly explored...

17 September - 20 September 2024

Reconstructing the human past: using ancient and modern genomics

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Combining genome wide data from ancient and modern populations opens new windows into the past and importantly their integration with archaeological evidence and historical records elucidates aspects of human history and cultural evolution of past societies Population scale sequencing projects investigating past and present human diversity have already provided us with extraordinary insights into patterns of human variation and mobility through time and space Moreover genome wide data from archaic human remains such as Neandertals and Denisovans allows to investigate human evolution in action and to provide direct insights into genetic changes that define our own lineage The available dataset of genome wide data from present day and archaic humans has risen exponentially since the first EMBO Reconstructing the human past meeting in 2019 This has drastically enhanced our ability to carry out further large scale studies on both global and local scales across deeply sampled time transects making it now possible to ask and answer questions that were simply impossible to address before in addition to motivating the development of new analytical methods Critically with new frontiers in data generation and analyses questions on ethical practices in paleogenomics need to be considered Furthermore the reconstruction of ancient pathogen genomes and metagenomic analysis of the oral and gut microbiomes provides us with molecular fossils to study microbial evolution through time The potential of ancient DNA data to reconstruct genomic variation of human associated animals and plants to understand the process of domestication and their evolutionary trajectory is equally promising to such studies in humans This meeting will involve scientists from population genetics bioinformatics microbiology anthropology archaeology and history and will strengthen future interactions in this young research field that is already changing the way we think about our past and will shape how we study genetic variation in the future Session topics Our closest living and extinct relatives Detecting patterns of selection Reconstructing the genetic history of human populations Ethical considerations and research practices in paleogenomics Integrating genetic and historical evidence Evolution of human pathogens microbiome and health New methods and avenues for ancient genomic data analysis What past participants say about the Symposium It was a wonderful opportunity to exchange science and get to know fellow researchers Choongwon Jeong Seoul National University Seoul I can t imagine a more dense and intense conference in the field of genomics of archaic humans I extremely enjoyed the conference and would like to give many thanks to the organisers who made it happen Danat Yermakovich cGEM Institute of Genomics University of Tartu Estonia Speakers Keynote speaker Svante P bo Max Planck Institute for Evolutionary Anthropology Germany Speakers Qiaomei Fu Chinese Academy of Sciences China Mateja Hajdinjak The Francis Crick Institute Max Planck for Evolutionary Anthropology UK Kelley Harris University of Washington USA Emilia Huerta Sanchez Brown University USA Diyendo Massilani Yale School of Medicine USA Andr s Moreno Estrada Cinvestav UGA Langebio Mexico Jennifer Raff University of Kansas USA Jazmin Ramos Madrigal University of Copenhagen Denmark David Reich Harvard University USA Anna Sapfo Malaspinas University of Lausanne Switzerland Christiana Scheib University of Tartu Estonia Mehmet Somel Middle East Technical University T rkiye Anna Sz cs nyi Nagy Hungarian Academy of Sciences Hungary Ray Tobler Australian National University Australia Christina Warinner Harvard University USA Scientific organisers Johannes Krause Max Planck Institute for Evolutionary Anthropology Germany Ida Moltke University of Copenhagen Denmark Maanasa Raghavan University of Chicago USA Pontus Skoglund The Francis Crick Institute UK Conference organisers Luana Ribeiro EMBL Heidelberg Germany Programme Are you on social media Post using EESHuman and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 17 September 2024 Time Europe Berlin Speaker12 00 13 30Registration and Light Refreshments13 30 13 45Opening Remarks13 45 14 45Keynote Lecture Archaic genomicsSvante P bo Max Planck Institute for Evolutionary Anthropology Germany14 45 16 15Session 1 Our closest living and extinct relativesChairs Johannes Krause Max Planck Institute for Evolutionary Anthropology GermanyPontus Skoglund The Francis Crick Institute UK14 45 15 15News from the Palaeolithic ancient genomes and neandertal human interactionsMateja Hajdinjak The Francis Crick Institute UK Max Planck for Evolutionary Anthropology Germany15 15 15 30The Neandertal growth hormone receptorHugo Zeberg Karolinska Institute Sweden15 30 15 45Simultaneous bidirectional crispr editing in cortical brain organoids uncovers hierarchical interactions among nearly fixed mutations specific to the sapiens lineageCedric Boeckx Catalan Institute for Advanced Studies and Research Spain15 45 16 00Uncovering the noncoding variants that shaped human evolution David Gokhman Weizmann Institute of Science Israel16 00 16 15A structured coalescent model reveals deep ancestral structure shared by all modern humans Trevor Cousins University of Cambridge UK16 15 16 45Coffee Break and Meet the Speakers16 45 18 45Session 2 Detecting patterns of selectionChairs Pontus Skoglund The Francis Crick Institute UKJohannes Krause Max Planck Institute for Evolutionary Anthropology Germany16 45 17 15The MUC19 gene in denisovans neanderthals and modern humans An evolutionary history of introgression and natural selectionEmilia Huerta Sanchez Brown University USA17 15 17 45Reconstructing the chronology of selection in maize domesticationJazmin Ramos Madrigal University of Copenhagen DenmarkNot available on demand17 45 18 00Three ancient DNA time transects from the Americas provide evidence for pre contact selection in Coastal Brazil the Central Andes and MesoamericaAlison Barton Harvard University USA18 00 18 15Recent expansion and evolutionary selection of human specific NOTCH2NLB allele enhancing cortical neurogenesisIkuo Suzuki The University of Tokyo Japan18 15 18 45Hundreds of findings of natural selection realize the promise of ancient DNA to elucidate human adaptationDavid Reich Harvard University USA18 45 19 30Flash Talk Session 1 45 Marcos Araujo Castro e Silva 55 Nicolas Brucato 57 Zehui Chen 59 Daniel R Cuesta Aguirre 65 Michal Feldman 73 Lei Huang 77 Xiaowen Jia 79 Dilek Koptekin 85 Zhi Li19 30 21 15Dinner in EMBL Canteen21 15 22 45After dinner drinks with live jazz music in ATC Foyer Day 2 Wednesday 18 September 2024 Time Europe Berlin Speaker09 00 14 30Session 3 Reconstructing the genetic history of human populationsChairs Ida Moltke University of Copenhagen Denmark Pontus Skoglund The Francis Crick Institute UK09 00 09 30The genetic history of Southern East AsiaQiaomei Fu Chinese Academy of Sciences ChinaNot available on demand09 30 10 00Kinship and gender roles in early Neolithic societies an Anatolian perspectiveMehmet Somel Middle East Technical University Turkey10 00 10 15Exploring genetic relationships of ceramic age Caribbean individuals from the Dominican RepublicJudith Ballesteros Villasc n Max Planck Institute for Evolutionary Anthropology Germany10 15 10 30Steppe ancestry in Western Eurasia and the spread of the germanic languages Hugh McColl Health Faculty Globe Institute Denmark10 30 11 00Coffee Break and Meet the Speakers11 00 11 30Reconstructing the evolution of the mutation rate and spectrumKelley Harris University of Washington USA11 30 11 45Long term continuity and genetic insights of the Punan Batu Understanding hunter gatherer resilience in Borneo Pradiptajati Kusuma Laboratory of Genome Diversity and Diseases Indonesia11 45 12 00First genetic insights into ancient population history in the Highlands of Papua New Guinea Konstantina Cheshmedzhieva University of Vienna Austria12 00 13 30Lunch and Meet the Editors13 30 14 00The future of our microbial past Christina Warinner Harvard University USA14 00 14 15Farming practices reduced generation intervals in post glacial Western Eurasia Mois s Coll Maci Aarhus University Denmark14 15 14 30Paleogenomic analyses of archaeological remains reveal sex roles and mobility of ancient families in central MexicoDaniela Orozco National Laboratory of Genomics for Biodiversity UGA LANGEBIO CINVESTAV Mexico14 30 15 00Coffee Break and Meet the Speakers15 00 15 30Flash Talk Session 2 48 Rodrigo Barquera 49 William Barrie 50 Owyn Beneker 93 Santiago Gerardo Medina Mu oz 101 Sandra Penske 107 Adam Ben Rohrlach 109 Susanna Sawyer 119 Laura Vil Valls 123 Matthew Williams 125 Wipada Woravatin15 30 17 00Poster Session 1 odd numbers 17 00Free Evening Day 3 Thursday 19 September 2024 Time Europe Berlin Speaker09 00 10 00Session 3 Reconstructing the genetic history of human populationsChairs Maanasa Raghavan University of Chicago USAJohannes Krause Max Planck Institute for Evolutionary Anthropology Germany09 00 09 30Reconstructing human migrations from genomic data across Latin America and the PacificAndr s Moreno Estrada Cinvestav UGA Langebio Mexico09 30 09 45Using 858 635 individuals haplotype sharing between British and Danish populations to infer the North Sea migration history Xiaolei Zhang EMBL EBI UK09 45 10 00The origin and composition of the forgotten people genetic analysis of the sarmatian period population of the carpathian basin Oszkar Schutz University of Szeged Hungary10 00 10 30Coffee Break and Meet the Speakers10 30 11 30Session 4 Ethical considerations and research practices in paleogenomicsChair Maanasa Raghavan University of Chicago USA10 30 11 00Engaged research with indigenous communities in North America an example from the Central and Southern PlainsJennifer Raff University of Kansas USA11 00 11 30The genetic origins and impacts of historical Papuan migrations into WallaceaRay Tobler Australian National University Australia11 30 11 45Discussion Ethics 11 45 15 00Session 5 Integrating genetic and historical evidenceChairs Ida Moltke University of Copenhagen DenmarkJohannes Krause Max Planck Institute for Evolutionary Anthropology Germany11 45 12 15Genomic investigations of the Early Medieval Southern Urals synthesis and future perspectivesAnna Sz cs nyi Nagy Hungarian Academy of Sciences Hungary12 15 12 30A 4 000 years old genome from Nuwayrat EgyptAdeline Morez The Francis Crick Institute Liverpool John Moores University UK12 30 12 45Unraveling the genomic history of European Jews Shamam Waldman Harvard University USA12 45 14 15Lunch14 15 14 45A genomic history of Rapa Nui and some methodological insights into ancient DNA analysisAnna Sapfo Malaspinas University of Lausanne Switzerland14 45 15 00Archaeogenetic insights into the biological and cultural connectedness of bronze age Crete Alissa Mittnik Max Planck Institute for Evolutionary Anthropology Germany15 00 17 00Session 6 Evolution of human pathogens microbiome and healthChairs Johannes Krause Max Planck Institute for Evolutionary Anthropology Germany Pontus Skoglund The Francis Crick Institute UK15 00 15 30Ancient genomes and other evidence in the study of the evolution of human pathogens and immune responseChristiana Scheib University of Tartu Estonia Virtual Not available on demand15 30 15 45Repeated plague infections across six generations of neolithic farmers Frederik Seersholm University of Copenhagen Denmark15 45 16 15Coffee Break and Meet the Speakers16 15 16 30Deep sequencing and de novo assembly of microbial sequences through non invasive sampling of 500 year old Inca mummies Michelle H mmerle University of Vienna Austria16 30 16 45Analysis of a 5 500 year old Treponema pallidum like genome from Sabana de Bogot Colombia Davide Bozzi University of Lausanne Switzerland16 45 17 00Paleogenomic reconstruction of pathogens from the 19th century epidemic in Tlatelolco Mexico Miriam Bravo International Laboratory for Human Genome Research Mexico17 00 17 45Flash Talk Session 3 56 Th o Cavinato 58 J r my Choin 60 Roslyn Curry 68 Lucia Franchini 70 Keith Daniel Harris 76 Iseult Jackson 90 Javier Maravall L pez 99 Cecilia Padilla Iglesias 104 Niraj Rai 106 Iker Rivas Gonz lez 120 Maria Teresa Vizzari17 45 19 15Poster Session 2 even numbers 19 15 21 00Conference Dinner 21 00 23 30Conference Party Day 4 Friday 20 September 2024 Time Europe Berlin Speaker09 30 12 00Session 7 New methods and avenues for ancient genomic data analysisChairs Pontus Skoglund The Francis Crick Institute UKIda Moltke University of Copenhagen Denmark 09 30 10 00Ancient human DNA from archaeological sedimentDiyendo Massilani Yale School of Medicine USA10 00 10 15A flexible new admixture dating approach to jointly analyse modern and ancient individuals sampled at different times Nancy Bird University College London UK10 15 10 30An efficient way to infer demographic history from the distribution of distances between heterozygous sites in diploid species Tommaso Stentella Max Planck Institute for Molecular Genetics Germany10 30 11 00Coffee Break and Meet the Speakers11 00 11 15Reconstructing phenotypic differences between ancient individuals Gili Greenbaum The Hebrew University of Jerusalem Israel11 15 11 30Accurate and robust inference of the relationship between two individuals using aDNA Alexandra Strang Natural History Museum and UCL UK11 30 11 45Population genetic analysis of Holocene Europeans using sediment nuclear DNA from open air living spaces Niall Cooke Max Planck Institute for Evolutionary Anthropology Germany11 45 12 00High resolution ancestry reconstruction of early Medieval Europe Leo Speidel University College London Francis Crick Institute UK12 00 12 15Closing Remarks and Poster Prize Announcements12 15Packed Lunch and Departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Luana Ribeiro for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 20 August 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 09 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergB B HotelStaycity Aparthotel HeidelbergHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the conference shuttle bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hans B ckler Stra e Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners FEBS Open Bio International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Molecular Systems Biology an EMBO Press Journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 729 90...

Johannes Krause, Ida Moltke, Maanasa Raghavan, Pontus Skoglund

15 September - 22 September 2024

Synthetic biology in action: engineering synthetic systems

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview Course overview Synthetic Biology SynBio has become a rapidly developing area for tackling a large number of challenges in life science research This is due to a combination of foundational advances in technologies such as large scale DNA synthesis and new methods that allow integrating such raw synthesis power into engineering approaches Those include genome wide small RNA regulation dCas9 based regulation and multiplexed genome engineering Such fresh approaches fuel new types of biotechnological applications with immense impact on both fundamental science and society This course will be offered in both onsite and virtual format with different modules available to each format It will provide the best and most exciting novelties in the field and focus on exploiting tools and concepts of SynBio for multi scale engineering of bacterial systems The intensive schedule includes lectures by experts in the field discussions poster sessions and importantly an experimental program Audience The course is directed to PhD students and early post doctoral researchers active in molecular biology biotechnology systems biology and bioengineering The experimental focus will be on microbiological systems Modules Resources The course will offer onsite participation wetlab practicals or computational practicals and virtual participation only computational practicals When submitting your letter of motivation please select virtual or onsite attendance and as such please note the difference in modules and activities available Kindly note onsite participants will be allocated to one of the below modules based on their submission preferences and will spend the entire practical session in the designated module Genome engineering with Multiplex Automated Genome Engineering MAGE wetlab onsite participants CRISPR based gene knock down in mammalian cells wetlab onsite participants RNA wide tools for system control wetlab onsite participants Exploring sequence and length diversity on the directed evolution of complex Boolean logic promoters wetlab onsite participants Creating and applying data driven models in biology for translation initiation engineering onsite and virtual participants Learning outcomes The participants will learn about the design and workflow of Synthetic Biology studies and gain understanding about the possibilities and limitations of synthetic biology in different areas What past participants say about the course By joining the course I discovered other research fields in SynBio and met great scientists among the lecturers and the participants I gained a lot in terms of knowledge and inspiration that will influence my own research in the years to come Alberto De Maria DTU Biosustain Kongens Lyngby Denmark The Synthetic biology in action beyond standard metabolism course offered me excellent practical and theoretical knowledge in the field It also provided an invaluable networking experience with experts and peers Elena Vel zquez Mu oz Centro Nacional de Biotecnolog a CNB CSIC Madrid Spain This course has a recommendation rate of 100 by previous attendees This event has been granted the following EMBO sustainability badge Grade 1 of 3 Speakers Speakers trainers and staff Uri Alon Weizmann Institute of Science Israel Chris Barnes University College London UK Fabiana Calandra Istituto Italiano di Tecnologia Italy Nico J Claassens Wageningen University The Netherlands Pascale Daran Lapujade TU Delft The Netherlands Daniel de la Torre Constructive Bio UK Marjan de Mey Ghent University Belgium Charlotte Desczyk University of Regensburg Germany Barbara Di Ventura University of Freiburg Germany Tom Ellis Imperial College London UK Tobias Erb Max Planck Institute for Terrestrial Microbiology Germany Jean Loup Faulon INRAE France Clemens Hausmann University of Regensburg Germany Kristien Hens Universtiy of Antwerp Belgium Nicolas Jaenisch University of Regensburg Germany Markus Jeschek University of Regensburg Germany Charlotte Koster Wageningen University The Netherlands Rosa M tt l KU Leuven Belgium Masue Marbiah Imperial College London UK Lucia Marucci University of Bristol UK June Medford Colorado State University USA Sven Panke ETH Z rich Switzerland Vitor B Pinheiro KU Leuven Belgium Karen Polizzi Imperial College London UK Yolanda Schaerli University of Lausanne Switzerland Petra Schwille Max Planck Institute of Biochemistry Germany Velia Siciliano Istituto Italiano di Tecnologia Italy Scientific organisers Nico J Claassens Wageningen University The Netherlands Sven Panke ETH Z rich Switzerland Vitor B Pinheiro KU Leuven Belgium Karen Polizzi Imperial College London UK Velia Siciliano Istituto Italiano di Tecnologia Italy Course organisers Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Manager EMBL Heidelberg Germany Christopher Stocks Team Lead EMBL Heidelberg Germany Programme Are you on social media Post using EMBOSynBio and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours may be required and if so will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Please note selected participants to attend onsite will spend the entire course in one of the course modules Day 0 Wednesday 11 September 2024 Time Europe Berlin SpeakerLocation13 00 15 30Welcome breaking the ice flash talks by all participants onsite and online and practicalitiesVitor Pinheiro KU Leuven BelgiumOnline Day 1 Sunday 15 September 2024 Time Europe Berlin SpeakerLocation15 00 15 15Bus from hotel to EMBL ATC EntranceISG Hotel15 15 15 45Welcome sessionVitor Pinheiro KU Leuven BelgiumCourtyard Room A B15 45 16 15Lab safety introductionEMBL house rulesIntroduction to treasure huntScientific Training Team EMBL Heidelberg GermanyCourtyard Room A B16 15 16 45Overview of the experiments to be run during the courseVitor Pinheiro KU Leuven BelgiumCourtyard Room A B16 45 17 15Coffee Break Treasure hunt part 1 onsite participants Outside of Courtyard Room A B17 15 17 45Introduction to practicalsCourtyard Room A B17 45 18 45Parallel practical sessions beginTraining Lab A B18 45 19 45Innaugural lectureBuilding new to nature metabolism in vitro and in vivoTobias Erb MPI Marburg GermanyCourtyard Room A B19 45 20 00Bus departure to ISG hotelEMBL ATC Entrance20 15 22 15BBQ dinner and networkingISG Hotel Day 2 Monday 16 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 09 30Treasure Hunt part 2 onsite participants Courtyard Room A B09 30 10 30Machine learning models applied to the SynBio engineering cycleJean Loup Faulon INRA FranceCourtyard Room A B10 30 11 00Coffee BreakOutside of Courtyard Room A B11 00 12 00Biosensors programming cells to monitor and react on their environmentMarjan de Mey Ghent University BelgiumCourtyard Room A B12 00 13 00Lunch BreakEMBL Canteen13 00 16 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B16 00 16 30Coffee BreakOutside of Courtyard Room A B16 30 18 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B18 00 19 00Presentations from participants 1 12Courtyard Room A B19 00 20 00DinnerEMBL Canteen21 00 21 30Update on laboratory workCourtyard Room A B21 30Bus departure to ISG HotelEMBL ATC Entrance Day 3 Tuesday 17 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 11 00Practicals MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B11 00 11 30Coffee BreakOutside of Courtyard Room A B11 30 12 30Optogenetics in synthetic biologyBarbara di Ventura University of Freiburg GermanyCourtyard Room A B12 30 13 30Lunch BreakEMBL Canteen13 30 14 00Technology Talk Writing the Future with Synthetic DNA Laurence Humphrey Max Stadler Twist BioscienceCourtyard Room A B14 00 16 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B16 00 16 30Coffee BreakOutside of Courtyard Room A B16 30 17 30Introducing novel metabolic pathways in yeastPascale Daran Lapujade TU Delft The NetherlandsCourtyard Room A B17 30 19 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B19 00 20 00DinnerEMBL Canteen20 00 21 00Presentations by participants 13 25Courtyard Room A B21 00Bus departure to ISG HotelEMBL ATC Entrance Day 4 Wednesday 18 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 11 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B11 00 11 30Coffee BreakOutside of Courtyard Room A B11 30 12 30Evolution of topology in regulatory circuitsYolanda Schaerli University of Lausanne SwitzerlandCourtyard Room A B12 30 13 30Lunch BreakEMBL Canteen13 30 15 30Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B15 30 16 00Coffee BreakOutside of Courtyard Room A B16 00 17 00Plant Synthetic BiologyJune Medford Colorado State University USACourtyard Room A B17 00 19 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B19 00 20 00Tapas DinnerRooftop Lounge20 00 21 00Update on laboratory workCourtyard Room A B21 00Bus departure to ISG HotelEMBL ATC Entrance Day 5 Thursday 19 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 11 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B11 00 11 30Coffee BreakOutside of Courtyard Room A B11 30 12 30Design engineering and control of microbial communitiesChris Barnes UCL UKCourtyard Room A B12 30 13 30Lunch BreakEMBL Canteen14 00 16 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B16 00 16 30Coffee BreakOutside of Courtyard Room A B16 30 17 30Keynote Parts circuits and genome engineering for Synthetic BiologyTom Ellis Imperial College London UKCourtyard Room A B17 30 19 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B19 00 20 00Pizza DinnerRooftop Lounge20 00 21 30Responsible conduct of research ethics and societal issues activity Guided exercise and facilitated discussionKristien Hens UAntwerp BECourtyard Room A B21 30Bus departure to ISG HotelEMBL ATC Entrance Day 6 Friday 20 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 11 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B11 00 11 15Coffee BreakOutside of Courtyard Room A B11 15 12 15Designing synthetic cellsPetra Schwille MPI Martinsried GermanyCourtyard Room A B12 15 13 00Lunch BreakEMBL Canteen13 00 15 00Practicals continued MAGE of bacteria CRISPR editing of mammalian genomes RNA wide tools for mammalian generegulation Sequence and length diversity in evolution Data driven models in SynBio onsite virtual Training Lab A B15 00 15 15Coffee BreakOutside of Courtyard Room A B15 15 16 15Design and control of cellular processes using mathematical modelling and cybergeneticsLucia Marucci University of Bristol UK virtual talk Courtyard Room A B16 15 17 15Informal discussion with remote speakersCourtyard Room A B17 15Departure to Neckarm nzplatz via ISG EMBL Bus stop18 00Guided tour of Heidelberg historical city centredowntown Heidelberg19 30Dinner downtownRoter Ochsen Day 7 Saturday 21 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 11 00Preparation of final reports by individual teamsCourtyard Room A B11 00 11 30Coffee BreakOutside of Courtyard Room A B11 30 12 30Synthetising codon removed genomesDaniel de La Torre Constructive BI UKCourtyard Room A B12 30 13 30Lunch BreakEMBL Canteen13 30Bus departure to ISG Hotel free afternoonEMBL ATC Entrance Day 8 Sunday 22 September 2024 Time Europe Berlin SpeakerLocation08 50 09 00Overview of the dayCourtyard Room A B09 00 11 00Presentation of results by individual teamsCourtyard Room A B11 00 11 30Coffee BreakOutside of Courtyard Room A B11 30 12 30Principles of biological designUri Alon Weizmann Institute of Science IsraelCourtyard Room A B12 30 13 00Treasure Hunt resultsCourtyard Room A B13 00 13 15Wrap up and farewell to onsite and online participantsCourtyard Room A B Practical Information Registration fees and motivation letter The course is limited to 20 onsite participants 5 virtual participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Onsite Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 Virtual Registration fees include course materials lectures Academia 190PhD Student 190Industry 250 For onsite participants a letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 15 September to 22 September 7 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost per night availability of single rooms may be limited This should be paid by you directly to the ISG Hotel during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings The shuttle bus schedule can be found here Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course On site participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software All participants will be requested to install software before the course Please make sure to bring the laptop with the installed software to the course You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions and travelling to EMBL on our Information for Participants page Sponsors Event partner Event sponsor Media partners Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Sven Panke, Vitor Pinheiro, Karen Polizzi, Nico Claassens, Velia Siciliano

11 September 2024

Technological advances and computational approaches for spatially-resolved transcriptomics

Description Spatially resolved transcriptomics enables high throughput gene expression profiling within the spatial context of tissues offering valuable insights into cellular function and tissue organisation By integrating spatial coordinates with gene expression data researchers can identify spatially co localised cell populations and uncover the spatial dynamics of gene expression This webinar will explore the latest technological advances and computational approaches for analysing spatially resolved transcriptomics data equipping participants to critically plan their experimental design and analyses...

9 September - 12 September 2024

Chemical biology 2024

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The conference sets the stage for the dissemination and exchange of new developments in diverse emerging fields within chemical biology It is the largest and longest standing conference in the field being a platform for inspiration collaboration and networking for researchers in academia and industry We aim to provide the possibility for every chemical biologist to meet and discuss with peers topics ranging from tool development to biological applications from computational protein design to new drug modalities Session topics Chemical biology meets drug discovery Chemical biology of posttranslational modifications Non coding RNA and unusual RNA products Lipids and lipidation Chemical biology technologies Peptide therapeutics and computational protein design Epigenetic and gene editing tools What past participants say about the conference The conference was very well organised with an amazing programme great speakers and it has proved a valuable source of information A very challenging and worthwhile experience Rosalba Sortino Institute for Bioengineering of Catalonia Spain The EMBO Chemical Biology Workshop 2020 was super Inspiring talks and very well organised I had the opportunity to give a short presentation and got interesting feedback and discussion Ma Florencia Sanchez Institute for Biochemistry University of Frankfurt Germany This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Keynote speakers Craig Crews Yale University USA Kai Johnsson Max Planck Institute for Medical Research Germany Sarah O Connor Max Planck Institute for Chemical Ecology Germany Speakers Luc Brunsveld Eindhoven University of Technology The Netherlands Yong Xiang Chen Tsinghua University China Bruno Correia EPFL Switzerland Bianxiao Cui Stanford University USA Maria Duca French National Centre for Scientific Research CNRS France Deborah Fass Weizmann Institute of Science Israel Pau Gorostiza Institute for Bioengineering of Catalonia Spain Ulrich Schopfer Novartis Switzerland Benjamin Schumann The Francis Crick Institute UK Sarah Slavoff Yale University USA Mikiko Sodeoka RIKEN Japan Thorsten Stafforst University of T bingen Germany Kristian Str mgaard University of Copenhagen Denmark Daniel Summerer TU Dortmund University Germany Olalla V zquez University of Marburg Germany Georg Winter CeMM Austria Christina Woo Harvard University USA Scientific organisers Yimon Aye Ecole Polytechnique Federale de Lausanne Switzerland Bryan Dickinson The University of Chicago USA Maja K hn University of Freiburg Germany Conference organisers Sophie Dutzi EMBL Heidelberg Germany Programme Are you on social media Post using EMBOChemBio and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 9 September 2024 Time Europe Berlin Session11 00 13 00 Registration and light refreshments13 00 13 10Opening remarksSession 1 Chemical Biology meets drug discoveryChairs Chayasith Uttamapinant Vidyasirimedhi Institute of Science and Technology Thailand andMilena Schuhmacher EPFL Switzerland13 10 13 45Targeted protein degradation via molecular gluesGeorg Winter CeMM Austria13 45 14 00Selective OSBP inhibition attenuates retrograde trafficking by triggering partial Golgi degradationNianzhe He Technical University of Denmark Denmark14 00 14 35Ligands for the E3 ligase substrate adapter cereblonChristina Woo Harvard University USANot available on demand14 35 15 05Coffee Break and meet the speakers15 05 15 40Targeted Therapies chemical biology for precision medicines Ulrich Schopfer Novartis SwitzerlandNot available on demand15 40 15 55Transferrin Receptor Targeting Chimeras TransTACs for targeted membrane and extracellular protein degradationXin Zhou Dana Farber Cancer Institute Harvard Medical School USANot available on demand15 55 16 10Chemoproteomic mode of action analysis of protein kinase degradersNicola Berner Technical University Munich Germany16 10 16 45Flash talk session even numbers 38 Archita Agrawal 46 Pavel Kielkowski 72 Carla Duval 78 Kyohhei Fujita 104 Eszter Kozma 108 Henriette L mmermann 126 Qunxiang Ong 130 Julia Pols 146 Nicholas Southern 150 Colin Swenson 154 Max Unger 158 Frederik Weber 160 Mingxuan Wu16 45 18 30Poster session 1 even numbers 18 30 19 30Keynote Session Induced Proximity Exploring new therapeutic modalitiesCraig Crews Yale University USA virtual Not available on demand19 30 21 00Canteen dinner Day 2 Tuesday 10 September 2024 Time Europe Berlin SessionSession 2 Chemical Biology of posttranslational modificationsChair Christina Woo Harvard University USA09 00 09 35EMBO Young Investigator LectureChemical precision tools to dissect protein glycosylationBen Schumann Francis Crick Institute UKNot available on demand09 35 09 50Chemical tools to study the SHP2 phosphatase in immune cellsCatia Pierotti University of Freiburg GermanyNot available on demand09 50 10 25Synthesis and bio functional application of diverse phosphorus containing proteins peptidesYong Xiang Chen Tsinghua University ChinaNot available on demand10 25 10 55Coffee Break and meet the editorsSession 3 Non coding RNA and unusual RNA productsChair Peng Zou Peking University China10 55 11 30Small molecules targeting non coding RNAsMaria Duca CNRS France11 30 11 45Accelerating protein engineering with viral based in vivo screening and evolution technologiesBryan Dickinson University of Chicago USA11 45 12 20Dissecting the functional implications of alternative start codonsSarah Slavoff Yale University USA12 20 14 00Lunch and meet the speakersSession 4 Lipids and lipidationChair Xuyu Liu The University of Sydney Australia14 00 14 35Live Cell Imaging Using Raman TagMikiko Sodeoka RIKEN JapanNot available on demand14 35 14 50Deconvoluting protein S acylation by the ZDHHC enzyme family in macrophagesAnne Schuhmacher Imperial College London UK14 50 15 05A genetically encoded photoproximity labeling approach for mapping protein territoriesNir Hananya Technion Israel Institute for Molecular Genetics Israel15 05 15 20Controlling properties composition and function of biomolecular condensates with a micropeptide killswitch Yaotian Zhang Max Planck Institute for Molecular Genetics Germany15 20 16 00Flash talk session odd numbers 41 Fernando Banales Mejia 43 Lydia Barber 65 Mariska de Munnik 81 Sara Gomes 85 Bj rn Hanf 101 Seungwoo Kim 113 Ella Livnah 115 Abbie Macmillan Jones 127 Gamze Nur Yapici 131 Lena Quambusch 141 Angelika Seliwjorstow 145 Daria Sokolova 153 Ricarda Toerner 155 Martin Witte 163 Masahiko Yoshimura 167 Taja Zeleznik Ramuta16 00 17 45Poster session 2 odd numbers 17 45 18 00Break18 00 19 00Keynote Session Recording the physiological history of cells with chemical labelingKai Johnsson Max Planck Institute for Medical Research GermanyNot available on demand19 00 21 00Canteen Dinner21 00 22 00After dinner drinks in ATC Foyer Day 3 Wednesday 11 September 2024 Time Europe Berlin SessionSession 5 Chemical Biology TechnologiesChairs Sarah Slavoff Yale University USAandOlalla Vazquez University of Marburg Germany09 00 09 35 Photoswitchable drugs to control neuronal activity with light from individual synapses to brain wavesPau Gorostiza Institute for Bioengineering of Catalonia SpainNot available on demand09 35 09 50Reprogramming protein translation in spatiotemporal stress responseDalu Chang cole Polytechnique F d rale de Lausanne Switzerland09 50 10 25Membrane curvature mediated integrin activation and drug discoveryBianxiao Cui Stanford University USA10 25 10 55Coffee Break and meet the editors10 55 11 30Modulating mucin glycoproteins for health maintenance and disease therapyDeborah Fass Weizmann Institute of Science Israel11 30 11 45An improved Caprola variant for recording calcium activityNicola Porzberg Max Planck Institute for Medical Research Germany11 45 12 00Genetically encoded photocatalysis for spatially restricted profiling of biomoleculesPeng Zou Peking University China12 00 12 15Targeting the fine tuned and localized production of reactive oxygen species by inhibiting NADPH oxidasesSara Marchese University of Pavia Italy12 15 14 00Lunch and meet the speakersSession 6 Peptide therapeutics and computational protein designChairs Andy Wilson University of Birmingham UKandGeorg Winter CeMM Austria14 00 14 35Targeting protein protein interactions in receptor complexesKristian Stromgaard University of Copenhagen Denmark14 35 14 50Unveiling hidden functions of post dietary electrophilic modifications in platelet pathophysiology using integrated phenotypic and chemoproteomic approachesXuyu Liu The University of Sydney Australia14 50 15 05A druggable ubiquitin like conjugation system controls hippo pathway activityMaya Bulos The Scripps Research Institute USANot available on demand15 05 17 30Poster session 3 all numbers 17 30 18 05Chemical biology approaches for a quantitative understanding of PPI stabilization or how to identify molecular gluesLuc Brunsveld Eindhoven University of Technology The NetherlandsNot available on demand18 05 18 20Understanding and manipulating protein protein interactions of Aurora A Kinase employing intrinsically disordered regionsAndy Wilson University of Birmingham UK18 20 18 55Expanding the universe of functional proteins by computational designBruno Correia Ecole Polytechnique Federale de Lausanne Switzerland19 00 21 00Conference Dinner21 00 00 00Conference Party with Band Day 4 Thursday 12 September 2024 Time Europe Berlin SessionSession 7 Epigenetics and genetic editing toolsChair Patrick Rabe University of Oxford UK09 00 09 35Designer proteins for decoding the function of epigenetic DNA modificationsDaniel Summerer TU Dortmund University GermanyNot available on demand09 35 09 50A tunable and versatile chemogenetic near infrared fluorescent reporterLina El Hajji Sorbonne Universit cole Normale Sup rieure Universit PSL CNRS France09 50 10 25Chemical biology tools for microbiologyOlalla Vazquez Marburg University GermanyNot available on demand10 25 10 55Coffee Break and meet the speakers10 55 11 30Frontiers in site directed RNA editingThorsten Stafforst University of Tubingen Germany11 30 11 45Recombinase controlled multiphase condensates for CRISPR based diagnosticsChayasith Uttamapinant Vidyasirimedhi Institute of Science and Technology Thailand11 45 12 45Keynote Session Chemistry of natural product pathwaysSarah O Connor Max Planck Institute for Chemical EcologyGermanyNot available on demand12 45 13 00Poster prize announcements closing remarks13 00 13 30Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact events embl de for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 12 August 2024 in some cases at special rates Please email the hotel directly quoting the booking code CHB24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergMeininger HeidelbergB B HotelHotel ISGPremier Inn Heidelberg CityHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the conference shuttle bus schedule here 28 August 2024 The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsor Sirius Fine Chemicals SiChem Event supporters Media partners EMBO Reports an EMBO Press journal FEBS Journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl org for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 Leaderboard 728 90...

Yimon Aye, Bryan Dickinson, Maja Köhn

9 September - 16 September 2024

Membrane protein expression, purification, and characterisation 3 (mPEPC3)

Description OverviewSpeakers and TrainersPreliminary pogrammePractical informationSponsorsMedia kit Overview Course overview This hands on course focuses on training participants on how to work with membrane proteins troubleshooting in the wet lab during solubilisation and reconstitution and conducting experiments at the beamlines and during early stages of cryoEM screening To perform integrated structural biology experiments well equipped crystallisation and cryo EM facilities as well as beamlines for SAXS for time resolved macromolecular crystallography will be used Audience Applicants in the early stage of their research careers mid to end of PhD project or early postdoctoral career will be given preference based on their application We also welcome applications from non academic labs Modules Transient transfection of mammalian cells for recombinant Integral Membrane Proteins IMP expression Generation of stable mammalian cell lines for IMP production Solubilisation and quality control of IMPs Reconstitution of membrane proteins Native mass spectrometry on endocytic adaptor proteins SAXS approaches for IMPs Time resolved X ray diffraction setups for going 4D and sample delivery for studying enzymatic reactions Time resolved serial crystallography of integral membrane proteins in lipidic cubic phase Negative stain a grid preparation and data recording b data analysis and 3D reconstruction Membrane protein modelling Learning outcomes Participants will enhance their knowledge and skills in structural studies of membrane proteins including expression and purification reconstitution biophysical characterisation and structural determination of integral membrane proteins Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course Speakers and Trainers Lucia Banci University of Florence Italy Kim Bartels University Medical Center Hamburg Eppendorf Germany Isabel Bento EMBL Hamburg Germany Clement Blanchet EMBL Hamburg Germany Osvaldo Burastero EMBL Hamburg Germany Lucas Defelipe EMBL Hamburg Germany Juan Du Van Andel Institute USA Jens Frauenfeld Salipro Biotech AB Sweden Melissa Graewert EMBL Hamburg Germany Steve Harborne Peak Proteins UK Rory Hennell James Centre for Structural Systems Biology Hamburg Germany Kevin Janson Center for Free Electron Laser Science CFEL Deutsches Elektronen Synchrotron DESY Germany Syma Khalid University of Oxford UK Janine Denise Kopicki Centre for Structural Systems Biology Hamburg Germany Jan Kosinski EMBL Hamburg Germany Kirill Kovalev EMBL Hamburg Germany Thomas Marlovits Universit tsklinikum Hamburg Eppendorf and Centre for Structural Systems Biology Germany Melanie McDowell Max Planck Institute of Biophysics Germany Pedram Mehrabi Max Planck Institute for the Structure and Dynamics of Matter Germany Amit Meir Ben Efraim University of Glasgow United kingdom Dmitry Molodenskiy EMBL Hamburg Germany Stephen Muench University of Leeds UK Thomas Mulvaney Centre for Structural Systems Biology Hamburg Germany Stephan Niebling EMBL Hamburg Germany Arwen Pearson Universit t Hamburg and Max Planck Institute for the Structure and Dynamics of Matter Germany Martin Pelosse EMBL Grenoble France Kim Remans EMBL Heidelberg Germany Jennifer Rothe Centre for Structural Systems Biology Hamburg Germany David Ruiz EMBL Hamburg Germany Mikhail Savitski EMBL Heidelberg Germany Wiebke Schultze Centre for Structural Systems Biology Hamburg Germany Eike Schulz Universit tsklinikum Hamburg Eppendorf Germany Markus Seeger University of Zurich Switzerland Azadeh Shahsavar University of Copenhagen Denmark Bettina Siebers University of Duisburg Essen Germany Henning Tidow Universit t of Hamburg Germany Charlotte Uetrecht Centre for Structural Systems Biology and Leibniz Institute of Virology Germany Katharina Veith EMBL Hamburg Germany David von Stetten EMBL Hamburg Germany Yexin Xie EMBL Heidelberg Germany Scientific Organisers Maria Garcia EMBL Hamburg Germany Simon Mortensen EMBL Hamburg Germany Kim Remans EMBL Heidelberg Germany Angelica Struve EMBL Hamburg Germany Henning Tidow Universit t Hamburg Germany Course Organisers Maria Mercedes Bacadare Goitia Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez EMBL Heidelberg Germany Preliminary pogramme Are you on social media Post using EMBOPEPC and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Day 1 Monday 9 September 2024 Time Europe Berlin SessionLocation09 00 09 30RegistrationCentre for StructuralSystems Biology CSSB Building 15 Ground Floor Foyer entrance next to Lecture Hall 09 30 09 45WelcomeMaria Garcia Alai EMBL Hamburg GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall09 45 10 30Lecture 1 Recombinant protein production in eukaryotic cells Introduction to practical session AKim Remans EMBL Heidelberg GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall10 30 11 30Lecture 2 Genome engineering for protein production in mammalian cells Introduction to practical session BMartin Pelosse EMBL Grenoble FranceCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall11 30 11 45Coffee breakEMBL Hamburg Building 48e Second Floor Terrace11 45 12 45Lecture 3 Native from native unique bacterial systems at the service of macromolecular bioimaging Introduction to practical session DAmit Meir Ben Efraim Glasgow University UKCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall12 45 14 00Lunch breakDESY Canteen Building 914 00 15 00Lecture 4 Fe siderophore transport and the power stroke mechanism in ABC transporters Introductionto practical session CHenning Tidow Universit t of Hamburg GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall15 00 16 00Flash Talks PresentationsCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall16 00 16 30Coffee breakEMBL Hamburg Building 48e Second Floor Terrace16 30 17 30Lecture 5 Integrative modelling tools for Cryo EMThomas Mulvaney Maya Topf Lab Centre for Structural Systems Biology and Leibniz Institute of Virology GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall17 30 18 30Poster session 1Centre for StructuralSystems Biology CSSB Building 15 Ground floor Foyer18 30 21 00Welcome dinner Day 2 Tuesday 10 September 2024 Time Europe Berlin SessionLocation08 50 09 00Overview of the dayCentre for StructuralSystems Biology CSSB Bulding 15 Ground Floor Foyer entrance next to Lecture Hall 09 00 10 00Lecture 6 Native mass spectrometry in biophysical and structural characterization of protein complexes Introduction to practical session ECharlotte Uetrecht Centre for Structural Systems Biology and Leibniz Institute of Virology GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall10 00 13 00Parallel practical session 1 with short coffee break Practical session A1 Transfection of HEK293F cells for recombinantprotein expression and analysis of expression of integral membrane proteins IMPs Practical session B CRISPR Cas editing of cell lines for integral membrane protein expressionPractical session C Quality control Solubilisation and biophysical characterisation of membrane proteinsPractical session E Native mass spectrometry on membrane adaptor proteins complexesPractical F SAXS on membrane proteinsCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 EMBL Hamburg 48e Building Ground Floor P12 beamline13 00 14 00Lunch breakDESY Canteen Building 914 00 17 00Parallel practical session 2 with short coffee break Practical session A1 Transfection of HEK293F cells for recombinantprotein expression and analysis of expression of integral membrane proteins IMPs Practical session B CRISPR Cas editing of cell lines for integral membrane protein expressionPractical session C Quality control Solubilisation and biophysical characterisation of membrane proteinsPractical session E Native mass spectrometry on membrane adaptor proteins complexesPractical F SAXS on membrane proteinsCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 EMBL Hamburg 48e Building Ground Floor P12 beamline17 00 18 00Flash Talks Presentations Centre for StructuralSystems Biology CSSB Building 15 Lecture Hall18 00 19 30Poster session 2Centre for StructuralSystems Biology CSSB Building 15 Ground floor Foyer19 30 22 00Dinner Day 3 Wednesday 11 September 2024 Time Europe Berlin SessionLocation08 50 09 00Overview of the dayCentre for StructuralSystems Biology CSSB Bulding 15 Ground Floor entrance next to Lecture Hall 09 00 10 00Lecture 7 Biophysical proteomics Mikhail Savitski EMBL Heidelberg GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall10 00 13 00Parallel practical session 3 with shortcoffee break Practical session A1 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical session B CRISPR Cas editing of cell lines for integral membrane protein expressionPractical session C Quality control Solubilisation and biophysical characterisation of membrane proteinsPractical session D Reconstitution technologies of membrane proteins liposomes and artificial bilayersPractical session J Bioinformatics AI tools and membrane protein modellingCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 13 00 14 00Lunch breakDESY Canteen Building 914 00 14 45Lecture 8 Same in the membrane The Salipro Platform for GPCRs and Ion Channels for Drug Development Jens Frauenfeld Salipro Biotech AB SwedenCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall14 45 15 00Coffee breakEMBL Hamburg Building 48e Second Floor Terrace15 00 18 00Parallel practical session 4Practical session A1 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical session C Quality control Solubilisation and biophysical characterisation of membrane proteinsPractical session E Native mass spectrometry on membrane proteins complexesPractical session G Time resolved X ray crystallography setups for going 4D and sample delivery for studying enzymatic reactionsPractical session I Cryo EM grid preparation data recording and 3D reconstructionCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 EMBL Hamburg 48e Building Ground Floor P14 EH2 beamline18 30 21 00Dinner Day 4 Thursday 12 September 2024 Time Europe Berlin SessionLocation08 50 09 00Overview of the dayCentre for StructuralSystems Biology CSSB Bulding 15 Ground Floor entrance next to Lecture Hall 09 00 12 00Parallel practical session 5 with short coffee break Practical session A2 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical session B CRISPR Cas editing of cell lines for integral membrane protein expressionPractical session F SAXS on membrane proteinsPractical session G Time resolved X ray crystallography setups for going 4D and sample delivery for studying enzymatic reactionsPractical session H Time resolved serial crystallography of integral membrane proteins in lipidic cubic phaseCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 EMBL Hamburg 48e Building Ground Floor P12 P14 EH2 beamline12 00 13 00Lecture 9 Membrane protein purification for single particle Cryo EM studies Juan Du Van Andel Institute USACentre for StructuralSystems Biology CSSB Building 15 Lecture Hall13 00 14 00Lunch breakDESY Canteen Building 914 00 17 00Parallel practical session 6Practical session A2 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical session B CRISPR Cas editing of cell lines for integral membrane protein expressionPractical session C Quality control Solubilisation and biophysical characterisation of membrane proteinsPractical session F SAXS on membrane proteinsPractical session G Time resolved X ray crystallography setups for going 4D and sample delivery for studying enzymatic reactionsCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 EMBL Hamburg 48e Building Ground Floor P12 P14 EH2 beamline17 00 17 30Coffee breakEMBL Hamburg Building 48e Second Floor Terrace17 30 18 30Lecture 10 Unlocking the Structural Basis for the Inhibition of amino acid Transporters Azadeh Shahsavar University of Copenhagen DenmarkCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall18 30 21 00Dinner Day 5 Friday 13 September 2024 Time Europe Berlin SessionLocation08 50 09 00Overview of the day09 00 10 00Lecture 11 Unraveling the Unique Properties of Archaeal Enzymes and Their Potential in Industrial Biocatalysis Bettina Siebers Universit t Duisburg Essen GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall10 00 13 00Parallel practical session 7 with short coffee break Practical A2 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical G Time resolved X ray crystallography setups for going 4D and sample delivery for studying enzymatic reactionsPractical H Time resolved serial crystallography of integral membrane proteins in lipidic cubic phasePractical F SAXS on membrane proteinsPractical J Bioinformatics AI tools and membrane protein modellingCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 01 228 and 02 228 EMBL Hamburg 48e Building Ground Floor P12 P14 beamline13 00 14 00Lunch breakDESY Canteen Building 914 00 15 00Lecture 12 Cryo EM on secretion systems Introduction to practical session 9Thomas Marlovits UKE Hamburg and Centre for Structural Systems Biology GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall15 00 16 00Lecture 13 Quality control for membrane proteins Melanie McDowell Max Planck Institute of Biophysics Frankfurt am Main GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall16 00 16 30Coffee breakEMBL Hamburg Building 48e Second Floor Terrace16 30 17 30Lecture 14 Simulating bacterial membrane proteins the importance of incorporating biological complexity Syma Khalid University of Oxford United KingdomCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall17 30 18 30Lecture 15 Introduction to TR crystallography Arwen Pearson Universit t Hamburg and Max Planck Institute for the Structure and Dynamics of Matter GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall19 00 22 00Dinner Day 6 Saturday 14 September 2024 Time Europe Berlin SessionLocation08 50 9 00Overview of the day09 00 10 00Lecture 15 Sybodies and membrane proteins happy together Markus Seeger University of Z rich SwitzerlandCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall10 00 13 00Parallel practical session 8 with short coffee break Practical A1 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical D Reconstitution technologies of membrane proteins liposomes and artificial bilayersPractical I Cryo EM grid preparation data recording and 3D reconstructionPractical J Bioinformatics AI tools and membrane protein modellingPractical H Time resolved serial crystallography of integral membrane proteins in lipidic cubic phaseCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 02 228 CryoEM facility Basement EMBL Hamburg 48e Building Ground Floor P14 beamline13 00 14 00Lunch breakDESY Canteen Building 914 00 15 00Lecture 17 Current challenges and solutions for sample preparation in single particle cryo EM Stephen Muench University of Leeds UKCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall15 00Free afternoon Excursion in Hamburg Day 7 Sunday 15 September 2024 Time Europe Berlin SessionLocation09 50 10 00Overview of the day10 00 13 00Parallel practical session 9 with short coffee break Practical A2 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical D Reconstitution technologies of membrane proteins liposomes and artificial bilayersPractical H Time resolved serial crystallography of integral membrane proteins in lipidic cubic phasePractical I Cryo EM grid preparation data recording and 3D reconstructionPractical J Bioinformatics AI tools and membrane protein modellingCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 02 228 CryoEM facility Basement EMBL Hamburg 48e Building Ground Floor P14 beamline13 00 14 00Lunch breakDESY Canteen Building 914 00 15 00Lecture 18 in cell NMRLucia Banci University of Florence ItalyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall15 00 16 00Meet the expert session 1 Pharmaceutical industry perspective on membrane protein research Dr Harm Jan Snijder Astrazeneca Lessons from membrane protein production for drug discovery projects Dr Julius Nitsche Proteros Biostructures GmbHCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall16 00 16 30Coffee breakEMBL Hamburg Building 48e Second Floor Terrace16 30 17 30Lecture 19 Visualizing nuclear pore complexes through cryo electron tomography and structural modeling Introduction to practical session 10Jan Kosinski EMBL Hamburg GermanyCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall17 30 18 30Lecture 20 Production of Folded and Functional Membrane Proteins for Drug Discovery Steve Harborne Peak Proteins UKCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall18 30 21 00Pizza dinner followed by a roundtable discussion on the different aspects of responsible conduct of researchCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall Ground Floor Day 8 Monday 16 September 2024 Time Europe Berlin SessionLocation08 50 09 00Overview of the day09 00 12 00Parallel practical session 10 with short coffee break Practical D Reconstitution technologies of membrane proteins liposomes and artificial bilayers Practical E Native mass spectrometry on membrane adaptor proteins complexesPractical G Time resolved X ray crystallography setups for going 4D and sample delivery for studying enzymatic reactionsPractical I Cryo EM grid preparation data recording and 3D reconstructionPractical J Bioinformatics AI tools and membrane protein modellingCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 02 228 CryoEM facility Basement EMBL Hamburg 48e Building Ground Floor P14 beamline12 00 13 00LunchCentre for StructuralSystems Biology CSSB Building 15 Ground floor13 00 14 00Meet the expert session 2 Biophysical Characterization of Ligand Binding to Membrane Transporter Proteins Dr Nathan Adams Nanotemper GmbH Biomolecular Characterization of membrane proteins with Mass Photometry Dr Sebastian Joecks Refeyn LtdCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall14 00 17 00Parallel practical session 11Practical A2 Transfection of HEK293F cells for recombinant protein expression and analysis of expression of integral membrane proteinsPractical D Reconstitution technologies of membrane proteins liposomes and artificial bilayersPractical E Native mass spectrometry on membrane adaptor proteins complexesPractical I Cryo EM grid preparation data recording and 3D reconstructionPractical H Time resolved serial crystallography of integral membrane proteins in lipidic cubic phaseCentre for StructuralSystems Biology CSSB Building 15 EMBL Laboratories 02 228 CryoEM facility Basement EMBL Hamburg 48e Building Ground Floor P14 beamline17 00 17 30Coffee BreakEMBL Hamburg Building 48e Second Floor Terrace17 30 18 30Wrap up sessionCentre for StructuralSystems Biology CSSB Building 15 Lecture Hall19 00 22 00Farewell barbecue dinner Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the DESY Guest House to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and transport Reservations for double room accommodation single bed at the Hotel Schmidt Reventlowstra e 60 22605 Hamburg have been made Note accommodation is included in the registration fee There is a direct bus connection to the campus from outside the hotel and it is also right beside the train station Othmarschen Further information Address EMBL Hamburg Notkestra e 85 Buliding 48e 22607 Hamburg GermanyFrom Hamburg airport take line S1 to Othmarschen 18 stops 45 min change to bus number 1 towards Rissen or Schenefelder Holt to Zum H nengrab DESY 5 stops 10 min From Hamburg Altona train station take bus number 1 to Zum H nengrab DESY 15 stops 25 min Ticket costs Public Transport ca 3 60 and a taxi will be around 45 Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course A laptop with preinstalled software will be provided to each participant Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL 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Maria Garcia Alai, Simon Mortensen, Kim Remans, Henning Tidow

2 September - 5 September 2024

Imaging mouse development

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview This workshop aims to bring together and help establish an emerging community with the common goal of four dimensional reconstruction of mammalian development A number of long standing questions surrounding the early development of mammals have been inaccessible to molecular research due to technical limitations and poor physical accessibility of these processes How is the body plan established in the early embryo How is morphogenesis coordinated with lineage specification The recent revolutions in advanced light microscopy and bioimage informatics have opened up completely new avenues to address these questions and make fundamental advances in our understanding of the developing mammalian embryo The workshop will bring together members of the mouse developmental community advanced microscopy computational image analysis and more broadly quantitative biology to raise awareness about the available techniques and foster a discussion about how we can utilize them to resolve the outstanding questions This will also be an excellent opportunity to have an open conversation about what tools are still needed and how to make large datasets publicly available Session topics Early development Advanced microscopy and analysis Post implantation development Biophysical characterisation and tools Theory and modelling This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Speakers Emma Andersson Karolinska Institutet Sweden Kazuhiro Aoki National Institute for Basic Biology Japan Ripla Arora Michigan State University USA Chii Jou Chan MBI Singapore Singapore Jan Ellenberg EMBL Heidelberg Germany Isabel Espinosa Medina Janelia Research Campus USA Takashi Hiiragi Hubrecht Institute The Netherlands Jean Leon Maitre Institut Curie France Danijela Matic Vignjevic Institut Curie France Kate McDole MRC LMB Cambridge UK Eszter Posfai Princeton University USA Robert Prevedel EMBL Heidelberg Germany Guillaume Salbreux University of Geneva Switzerland Melina Schuh Max Planck Institute for Multidisciplinary Sciences Germany Miquel Sendra Spanish National Center for Cardiovascular Research CNIC Spain James Sharpe EMBL Barcelona Spain Shankar Srinivas University of Oxford UK Hari Shroff Janelia Research Campus USA Ann Sutherland University of Virginia USA C cile Sykes Ecole Normale Sup rieure CNRS France Scientific organisers Jan Ellenberg EMBL Heidelberg Germany Kate McDole MRC LMB Cambridge UK Isabel Espinosa Medina Janelia Research Campus USA Robert Prevedel EMBL Heidelberg Germany Shankar Srinivas University of Oxford UK Conference organiser Julia Patricia Nohle Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOMouseDev and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 2 September 2024 Time Europe Berlin Session12 00 13 00Registration and light refreshments13 00 13 15Opening remarks13 15 18 55Session 1 Pre implantation developmentChair Robert Prevedel EMBL Heidelberg Germany13 15 13 40Dissection of zygotic spindle assembly in the mouse embryo using advanced light sheet microscopyJan Ellenberg EMBL Heidelberg Germany available on demand after live stream 13 40 14 05Spatial patterning of mitochondrial energy production in mouse oocytes Yash Rana Harvard University USA available on demand after live stream 14 05 14 30Uncovering temporal regulation mechanisms in mouse diapause Eleonore Ocana Babraham Institute UK available on demand after live stream 14 30 14 55Mechano hydraulic control of mammalian ovarian follicle developmentChii Jou Chan MBI Singapore Singapore available on demand after live stream 14 55 15 30Break and Meet the speakers15 30 15 55New insights into oocyte meiosisMelina Schuh Max Planck Institute for Multidisciplinary Sciences Germany available on demand after live stream 15 55 16 20Exploring nucleocytoplasmic dynamics in mouse preimplantation embryos insights into early developmentManon Lesage Institut Curie France available on demand after live stream 16 20 16 45New insight into genome integrity protection in early mammalian embryos D vid Drutovic Institute of Animal Physiology and Genetics of the Czech Academy of Sciences Czech Reublic available on demand after live stream 16 45 17 15Break and Meet the speakers17 15 17 40A tug of war between germ cell motility and stable intercellular bridges determines cyst size in miceEszter Posfai Princeton University USA available on demand after live stream 17 40 18 05NODAL signaling is required for blastocyst development in the mouse Futura Gattobigio Institut Jacques Monod France available on demand after live stream 18 05 18 55Flash talk session 39 Ioakeim Ampartzidis 40 Mariana Barroso 41 Davide Benvegn 42 Madeleine Chalifoux 44 Yassin Harim 45 Chanchal Thomas Manully 46 Konstantinos Miti 47 Joanna Suszynska Zajczyk 48 Jake Turley 49 Michaela Va kovicov 50 Anoop Vadakan Cherian 51 Ling Wang18 55 20 10Dinner20 10 21 30After dinner drinks and pub quiz Day 2 Tuesday 3 September 2024 Time Europe Berlin Session09 30 12 05Session 2 Advanced microscopy and analysisChair Shankar Srinivas University of Oxford UK09 30 09 55Imaging and dynamic analysis of the post implantation mouse embryoKate McDole MRC LMB Cambridge UK09 55 10 203DMOUSEneST A method using three dimensional label free higher harmonic generation microscopy for evaluation of decidualization efficacy in miceAudrey Savolainen University of Oulu Finland available on demand after live stream 10 20 10 45Advancing optical methods to study mouse development in vivoRobert Prevedel EMBL Heidelberg Germany available on demand after live stream 10 45 11 15Coffee Break and Meet the speakers11 15 11 40Data driven image restorationHari Shroff HHMI Janelia Research Campus USA available on demand after live stream 11 40 12 05Brillouin microscopy for live imaging of mechanical properties in biologyCarlo Bevilacqua EMBL Heidelberg Germany available on demand after live stream 12 05 13 00Lunch and Meet the speakers13 00 18 30Session 3 Early embryogenesisChair Kate McDole MRC LMB Cambridge UK13 00 13 25Illuminating the uterine path from embryo movement to implantationRipla Arora Michigan State University USA available on demand after live stream 13 25 13 50Effects of blastocyst elongation and implantation chamber formation on the alignment of the embryonic axis and uterine axisToshihiko Fujimori National Institute for Basic Biology Japan13 50 14 15Deep tissue spatial omics Imaging whole embryo transcriptomics and subcellular structures at high spatial resolutionZhe Liu HHMI Janelia Research Campus USA available on demand after live stream 14 15 14 40Optimality for developmental robustnessTakashi Hiiragi Hubrecht Institute The Netherlands available on demand after live stream 14 40 15 10Coffee Break and Meet the speakers15 10 15 35Behavioural and mechanical heterogeneities underpin cell migration essential for mouse anterior patterningShankar Srinivas University of Oxford UK available on demand after live stream 15 35 16 00In toto multi tissue analysis using light sheet imaging reveals VE epiblast counter flow during anterior patterningMatthew Stower University of Oxford UK available on demand after live stream 16 00 16 25A place and time to die selective cell death and morphogenesis of the mammalian foregut pocketJenny Kretzschmar MRC Laboratory of Molecular Biology UK16 25 17 00Coffee Break and Meet the speakers17 00 18 30Poster session18 30Free evening Day 3 Wednesday 4 September 2024 Time Europe Berlin Session10 30 13 05Session 4 Advanced toolsChair Robert Prevedel EMBL Heidelberg Germany10 30 10 55TEMPO enables sequential genetic labelling and manipulation of vertebrate cell lineagesIsabel Espinosa Medina HHMI Janelia Research Campus USA10 55 11 20In vivo and ex vivo approaches to study the development of pancreatic innervationJoaquin Lilao Garzon HHMI Janelia Research Campus USA11 20 11 45Mapping embryonic development with ultrasound guided in utero next generation single cell lineage tracingEmma Andersson Karolinska Institutet Sweden available on demand after live stream 11 45 12 15Coffee Break and Meet the speakers12 15 12 40Optogenetics and live cell imaging visualize the dynamic regulation of cell surface tension and cell cell junctionsKazuhiro Aoki National Institute for Basic Biology Japan available on demand after live stream 12 40 13 05Reconstituting mouse embryogenesis ex uteroAlejandro Aguilera Castrejon HHMI Janelia Research Campus USA13 05 13 30C3PO Cell 3D Positioning by Optical encoding and its application to spatial transcriptomicsJames Sharpe EMBL Barcelona Spain available on demand after live stream 13 30 14 30Lunch and Meet the speakers14 30 17 30Session 5 OrganogenesisChair Isabel Espinosa Medina HHMI Janelia Research Campus USA14 30 14 55Live mapping of cardiac specification in gastrulating mouse embryosMiquel Sendra CNIC Spain available on demand after live stream 14 55 15 20Visualising the emergence of patterned calcium oscillations within the developing mammalian heartShifaan Thowfeequ University of Oxford UK available on demand after live stream 15 20 15 45Plasticity of ventricle position after heart looping in heterotaxyAudrey Desgrange Universit Paris Cit Imagine Institut Pasteur France available on demand after live stream 15 45 16 15Coffee break and Meet the speakers16 15 16 40Regulation of cell intercalation in the developing neural tubeAnn Sutherland University of Virginia USA available on demand after live stream 16 40 17 05Imaging isoforms in the developing cerebral cortexInes Gonzalez Aspe Instituto Cajal CSIC Spain available on demand after live stream 17 05 17 30Unexpected differentiation patterns during development and regeneration of hair cells in the inner earDavid Sprinzak Tel Aviv University Israel available on demand after live stream 17 30 17 55Homeostasis of gut epithelium under mechanical stressDanijela Matic Vignjevic Institut Curie France available on demand after live stream 17 55 18 45Pre dinner drinks18 45 19 45Conference dinner in the canteen19 45 22 15Networking Day 4 Thursday 5 September 2024 Time Europe Berlin Session10 00 11 55Session 6 BiomechanicsChair Isabel Espinosa Medina HHMI Janelia Research Campus USA10 00 10 25Active surfaces and biological morphogenesisGuillaume Salbreux University of Geneva Switzerland available on demand after live stream 10 25 10 50Mechanics of blastocyst morphogenesisJean Leon Maitre Institut Curie France available on demand after live stream 10 50 11 15Critical phenomenon associated with luminogenesis during ovarian follicle developmentKim Whye Leong Mechanobiology Institute Singapore available on demand after live stream 11 15 11 40Inferring cell nucleus translocation during squeezed motility of MEF cellsC cile Sykes Institut Curie France available on demand after live stream 11 40 11 55Closing Remarks and Poster Prize Announcements11 55 12 25Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 550On site PhD Student 350On site Industry 750On site Journal Editors 300Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Julia Patricia Nohle for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 4 weeks before check in date in some cases at special rates Please email the hotel directly quoting the booking code IMD24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 Conference shuttle bus schedule View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event sponsor Bruker Event supporter Media partners EMBO Reports an EMBO Press journal Development The Company of Biologists journal International Union of Biochemistry and Molecular Biology Imaging and Microscopy a Wiley magazine Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of 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Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 729 90...

Jan Ellenberg, Kate McDole, Isabel Espinosa Medina, Robert Prevedel, Shankar Srinivas

1 September - 6 September 2024

Genome engineering: CRISPR/Cas in cells and mice

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR Cas9 system Participants will learn design of CRISPR targets using bioinformatics tools generation of gene knock outs knock ins and target validation using the most current technologies The course will be split into two groups mammalian cells OR mice based on participants expertise Please note that all participants are expected to engage in all sessions Participants should plan for approximately 1 hour extra per day for self paced learning modules Audience This course is aimed at researchers who are familiar with basic molecular and cell biology techniques and who want to learn how to create an engineered mammalian cell line or mouse model using the most recent and advanced CRISPR Cas9 system No previous experience in genome editing is required Modules resources How to create a CRISPR Cas9 experiment using various design tools Transfection optimisation for efficient gene editing Generation of knock out and knock in cell lines and mouse embryos Validation of genome edited cell lines and embryos Learning outcomes After this course you should be able to Design a CRISPR based project using editing tools for your target gene of interest Choose the right format of gene editing tool and delivery strategy for your cell type or embryos Edit screen and validate the engineered models embryo manipulation What past participants say about the course The EMBL course about CRISPR applications for genome engineering was an incredible experience From the quality of the lectures the availability of the invited speakers to respond to all questions and doubts the openness and diversity of participants to the great organization and the impressive facilities and core facility teams working there It all created a perfect atmosphere for learning about this groundbreaking technique and the inspiring work being done with it as well as great networking I highly recommend this course Sofia Morazzo International Clinical Research Center Czech Republic The course covers all you need to organise your CRISPR experiments in great detail The speakers are fantastic and eager to help with your specific questions The organisation is also fantastic where you only have to think on CRISPR and nothing else Sergio G San Miguel Max Planck Institute for Infection Biology Germany Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers Antony Adamson University of Manchester United Kingdom Michela Ascolani EMBL Rome Italy Dana Carroll University of Utah School of Medicine USA Adrianna Castillo EMBL Rome Italy Silke Deckert Thermo Fisher Scientific Germany IDT Technologies Germany Neil Humphreys EMBL Rome Italy Manuel Kaulich Frankfurt University Hospital Germany Kristof Kersse Thermo Fisher Scientific Germany Birgit Koch Max Planck Institute for Medical Research Germany Frank Montoya EMBL Heidelberg Germany Beate Neumann EMBL Heidelberg Germany Alexandre Paix Max Planck Institute for Biology T bingen Germany Karl Petri Universit tsklinikum W rzburg Germany Ian Pringle Thermo Fisher Scientific United Kingdom Kim Remans EMBL Heidelberg Germany Isabel Rollan EMBL Heidelberg Germany Daniel Schraivogel EMBL Heidelberg Germany Maj Simonsen Jackson EMBL Rome Italy Emmanouela Soura Thermo Fisher Scientific United Kingdom Sandra Stobrawa Biozol Calibre Scientific Germany Scientific Organisers Neil Humphreys EMBL Rome Italy Kristof Kersse Thermo Fisher Scientific Germany Birgit Koch Max Planck Institute for Medical Research Germany Elisabeth Zielonka EMBL Heidelberg Germany Course Organisers Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Training Laboratory Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLCRISPRcas and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 1 September 2024 Time Europe Berlin SessionLocation16 00 16 30WelcomeEMBL housenotes and course overviewISG Hotel16 30 18 00Icebreaker Flash talks 2 slides 2 minutes each participant ISG Hotel18 00 19 00 Virtual speaker Live Keynote Lecture Introduction to CRISPR Cas 9 Dana Carroll University of Utah School of Medicine USAISG Hotel19 00Dinner and Networking at ISG HotelISG Hotel Day 2 Monday 2 September 2024 Time Europe Berlin SessionLocation08 30 08 45Bus from ISG Hotel to EMBL08 45 09 00Arrival and coffeeCourtyard Room9 00 9 15Lab Safety Swetlana KrezCourtyard Room09 15 10 15Lecture Purification of Cas9 proteinKim Remans EMBL Heidelberg GermanyCourtyard Room10 15 11 15Lecture CRISPR Cas genome editing to generate transgenic miceNeil Humphreys EMBL Rome ItalyCourtyard Room11 15 11 45Coffee breakCourtyard Room11 45 12 45Everyone Practical 1 gRNA design manual approach Kristof Kersse Thermo Fisher Scientific GermanyCourtyard Room12 45 13 45LunchEMBL Canteen13 45 16 00Everyone Practical 1 gRNA design Basics Benchling Birgit Koch Max Planck Institute for Medical Research GermanyCourtyard Room16 00 16 30Coffee breakCourtyard Room16 30 17 15Mammalian Cell Group Practical 1 1 TrueTag Donor Template Synthesis PCREmmanouela Soura Thermo Fisher Scientific UK Ian Pringle Thermo Fisher Scientific UKTraining Lab A16 30 17 15Short seminar on embryo transfer and demonstrationNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Diego Montoya Castillo EMBL Heidelberg GermanyTraining Lab B17 15 18 30CRISPR Cas in different organismsTips pitfalls and trouble shootingAlexandre Paix Max Planck Institute for Biology T bingen GermanyCourtyard Room18 30 19 30Dinner EMBL Canteen19 30 20 30Practical 1 2 Mammalian Cell Group TrueTag Donor Template Synthesis Gel analysis and Clean upEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKTraining Lab A19 30 20 30Glass transfer pipet prep harvest embryos Intro to TLR2 system describe injection mix prepNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Diego Montoya Castillo EMBL Heidelberg GermanyTraining Lab B20 30Bus from EMBL to ISG Hotel Day 3 Tuesday 3 September 2024 Time Europe Berlin SessionLocation08 30 08 45Bus from ISG Hotel to EMBL08 45 08 55Arrival and coffeeCourtyard Room08 55 09 00Overview of the dayCourtyard Room9 00 10 00Lecture A rationale for efficient genome editing using linear repair donorsAlexandre Paix Max Planck Institute for Biology T bingen GermanyCourtyard Room10 00 11 00Practical lecture Generation and validation of endogenously tagged cell lineBirgit Koch Max Planck Institute for Medical Research GermanyCourtyard Room10 00 11 00Practical AAV infectionMaj Simonsen Jackson EMBL Rome Italy Michela Ascolani EMBL Rome Italy Neil Humphreys EMBL Rome ItalyTraining Lab B11 00 12 45Practical Group A Transfection of endogenously tagged cell line duplex formation formation of RNP and transfection with CRISPR Birgit Koch Max Planck Institute for Medical Research Germany Group B True Design Tool and example exercises Kristof Kersse Thermo Fisher Scientific GermanyCell culture11 00 12 45Practical 1 2 1st Microinjection electroporationElectroporation Maj Simonsen Jackson EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMicroinjection Neil Humphreys EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Diego Montoya Castillo EMBL Heidelberg GermanySandra Stobrawa Biozol Calibre ScientificTraining Lab BLAR12 45 13 45LunchEMBL Canteen13 45 15 30Practical Group A True Design Tool and example exercisesKristof Kersse Thermo Fisher Scientific GermanyGroup B Transfection of endogenously tagged cell line duplex formation formation of RNP and transfection with CRISPRBirgit Koch Max Planck Institute for Medical Research GermanyCourtyard Room Cell culture13 45 15 30Mouse Embryo Group 2nd Microinjection electroporation and AAVElectroporation Maj Simonsen Jackson EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMicroinjection Neil Humphreys EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Diego Montoya Castillo EMBL Heidelberg GermanySandra Stobrawa Biozol Calibre ScientificTraining Lab BLAR15 30 16 00Coffee breakCourtyard Room16 00 18 00Practical 2 3 Mammalian Cell GroupGroup A gRNA efficiency Lipid transfection of 293FT cells with gRNA and Cas9 protein Lipid transfection of 293FT eBFP cells with gRNA Cas9 protein and ssODNEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKGroup B gRNA taskBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyCourtyard Room Cell culture16 00 18 00Mouse Embryo Group 3rd Microinjection electroporation and AAVElectroporation Maj Simonsen Jackson EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMicroinjection Neil Humphreys EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Diego Montoya Castillo EMBL Heidelberg GermanySandra Stobrawa Biozol Calibre ScientificTraining Lab BLAR18 00 19 00Dinner EMBL Canteen19 00 20 30Practical Group A gRNA taskBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyGroup B gRNA efficiency Lipid transfection of 293FT cells with gRNA and Cas9 protein Lipid transfection of 293FT eBFP cells with gRNA Cas9 protein and ssODNEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKCell culture19 00 20 30Practical 2 3Mouse Embryo GroupExtra time with Embryos microinjection and embryos transfer KSOM mediaO N culture Student lead requests for extra training All trainersTraining Lab B20 30Bus from EMBL to ISG Hotel Day 4 Wednesday 4 September 2024 Time Europe Berlin SessionLocation08 30 08 45Bus from ISG Hotel to EMBL08 45 08 55Arrival and coffeeCourtyard Room08 55 09 00Overview of the dayCourtyard Room09 00 10 00Lecture Gene editing in different experimental modelsAntony Adamson The University of Manchester UKCourtyard Room10 00 11 00Practical Harvest cells and prepare for FACS analysisBirgit Koch Max Planck Institute for Medical Research GermanyCell culture10 00 11 00Practical 4 Assess and clean up 2 cell microinjected embryosMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Diego Montoya Castillo EMBL Heidelberg GermanyTraining Lab B11 00 11 30Coffee breakCourtyard Room11 30 12 30Lecture Safety validating and improving CRISPR 2 0 to enhance immune cell therapiesKarl Petri Universit tsklinikum W rzburg GermanyCourtyard Room12 30 13 30LunchEMBL Canteen13 45 15 45Practical 1 3 4 Mammalian Cell Group Group A Tag Knock in Electroporation of 293FT with gRNA Cas9 protein and TrueTag donor templateEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKGroup B Project discussionBirgit Koch Max Planck Institute for Medical Research GermanyKristoff Kersse Thermo Fisher Scientific GermanyCourtyard Room Cell culture13 45 15 45Practical 4 Mouse Embryo Group Thaw pre prepared blastocysts assess viability extract DNA Design and set up cut test PCR Prepare agarose gelNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL HeidelbergTraining Lab B15 45 16 15Coffee break16 15 18 15Practical 1 3 4 Mammalian Cell Group Group A Project discussionBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyGroup B Tag Knock in Electroporation of 293FT with gRNA Cas9 protein and TrueTag donor templateEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKCourtyard Room Cell culture16 15 18 15Practical 5 Mouse Embryo Group Set up T7 assay and mutant specific PCRs Run O N project discussion Neil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyTraining Lab B18 15 20 30Pizza Dinner andDiscussion round and drinks Ethical issues of CRISPR technology and genome engineeringLead Antony Adamson The University of Manchester UKATC Rooftop lounge20 30Bus to ISG Hotel Day 5 Thursday 5 September 2024 Time Europe Berlin SessionLocation08 30 08 45Bus from ISG Hotel to EMBL08 45 08 55Arrival and coffeeCourtyard Room08 55 09 00Overview of the dayCourtyard Room09 00 10 00Lecture Imaged based high throughput screening RNAi vs CRISPRBeate Neumann EMBL Heidelberg GermanyCourtyard Room10 00 11 45Practical in Groups Practicals 5 1 5 2 Mammalian Cell Group GCD Cell Harvest and lysis set up GCD PCREmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKCell culture Training Lab A10 00 11 45Mouse Embryo Group Practicals 5 1 5 2Assess and clean up 4 to 8 cell embryos Run Gels for PCRs Analyze results Cut out gel and submit for Sanger sequencingNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyTraining Lab B11 45 12 15Group PhotoTBC12 15 13 15LunchEMBL Canteen13 15 14 15Lecture The 3Cs technology for CRISPR gRNA library generationManuel Kaulich Goethe University GermanyCourtyard Room14 15 16 30Practical in Groups Practical 5 3 Mammalian Cell Group PCR analysis set up GCD re annealing reactionPractical 5 4 5 5Set up digestion for GCD gel purification sample submission for sanger sequencingGel analysis of GCDEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKTraining Lab A14 15 16 30Mouse Embryo Group Project discussion focus on the analysis of sequencing data and design optionsNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyAntony Adamson The University of Manchester UKTraining Lab B16 30 17 00Coffee breakCourtyard Room17 00 18 00Lecture Pooled genome wide CRISPR screens in single cellsDaniel Schraivogel EMBL Heidelberg GermanyCourtyard Room18 15Bus departure to ISG Hotel19 00Bus from ISG Hotel to Dinner downtown19 30Downtown dinnerZum Roten Ochsen Day 6 Friday 6 September 2024 Time Europe Berlin SessionLocation08 30 08 45Bus from ISG Hotel to EMBLCourtyard Room08 45 08 55Arrival and coffeeCourtyard Room08 55 09 00Overview of the dayCourtyard Room9 00 10 30Technology Lounge Genome modification technologiesPresentation by different companiesThermo Fisher ScientificNew England Biolabs Karl von Laer Integrated DNA Technologies Marc Bleischwitz and K Julia Duda Courtyard Room10 30 12 30Practical in Groups Mammalian Cell Group Group A Examine BFP cells and TrueTag Knock in via microscopy and FACSEmmanouela Soura Thermo Fisher Scientific UKIan Pringle Thermo Fisher Scientific UKGroup B Knock In cell validation DNA Preparation and set up of PCR at the end of sessionBirgit Koch Max Planck Institute for Medical Research GermanyChange Groups after 60 minwith concurrent coffee breakTraining Lab A10 30 11 30Mouse Embryo Group Thaw TLR2 embryos and examine KO and KI morular blastocysts for florescence Knock In validation Neil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyTraining Lab B11 30 12 305 participants Image embryos ALMF 5 participants Project discussionNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyBeate Neumann EMBL Heidelberg GermanyALMFCourtyard Room12 30 13 30LunchEMBL Canteen13 30 15 45Mammalian Cell Group Knock In cell validation Gel gel analysisBirgit Koch Max Planck Institute for Medical Research Germanywith IC tour or other tour Training Lab A13 30 14 305 participants Image embryos ALMF 5 participants Project discussionNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyBeate Neumann EMBL Heidelberg GermanyALMFCourtyard Room14 30 15 45Mouse embryo group Tour of LAR FacilityErnesto de la Cueva Bueno EMBL HeidelbergLAR15 45 16 15Solutions room and final wordsCourtyard Room16 30Bus shuttle downtown and central station Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 815PhD Student 815Industry 1325 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights from Saturday 31 August 2024 Friday 6 September 2024 at the ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course e g GEE24 01 by the deadline of Monday 5 August 2024 We recommend that all course participants stay in the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event Partner Event Sponsor Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Neil Humphreys, Kristof Kersse, Birgit Koch, Elisabeth Zielonka

1 September - 10 September 2024

Current methods in cell biology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview In the past decade cell biology has undergone transformational changes resulting from improvements in single molecule imaging technologies and in situ structural biology At the same time the emergence of deep learning approaches that have revolutionised the field of image analysis together with techniques that complement imaging approaches to e g dissect the mechanical properties of cells have provided a wealth of quantitative high dimensional data for cell biologists The wealth of data available to cell biologists also comes with new challenges in data handling data analysis and data interpretation To allow researchers to design appropriate experiments and translate the data into meaningful knowledge requires insight into which techniques are best suited to address a specific question which techniques can or must be combined and how the output is best analysed and interpreted The Current methods in cell biology course aims to expose researchers with different backgrounds to the diverse cutting edge methods developed for cell biology to showcase how integrated approaches can address the current big questions in cell biology By attracting a diverse group of participants and exposing them to the recent advances in cell biology the course will equip the participants with the tools to further advance the field The practical sessions will take place in parallel and groups will rotate Participants must select 3 topics out of 11 for practicals 1 3 and 2 topics out of 3 for practicals 4 5 Audience The course will be targeted primarily for postdocs and advanced graduate students who have developed an interest in cell biology We aim to attract a diverse group of scientists who want to expand their expertise by acquiring cutting edge quantitative cell biological biophysical and computational methods to address current problems in cell biology We aim to balance the number of participants with a background in biology and participants coming from other disciplines A key criterion for selection is the potential benefit of adding novel cell biological methods to the participant s own research plans Preference will be given to applicants where there is little or no possibility that the applicant can acquire these technologies at their home institution What past participants say about the course This course has changed my perspective in many aspects of cell biology and allowed me to rethink how to perform crucial experiments The interaction with other participants and the speakers has been without a doubt the best providing an excellent platform for networking during the 10 days of the course Highly recommended in the next editions Anchel de Jaime Soguero COS Heidelberg Germany A wonderful way to learn about and be inspired by new advances in cell biology research The enthusiasm of those teaching made the course stand out as a unique opportunity Victoria Hart University of Sheffield UK This course is kindly supported by the Cell Biology and Biophysics Unit of EMBL Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course This event has been granted the following EMBO sustainability badge Grade 1 of 3 Speakers Speakers trainers and staff Niccol Banterle EMBL Heidelberg Germany Florian Berger Utrecht University The Netherlands Beth Cimini Broad Institute USA Sara Cuylen H ring EMBL Heidelberg Germany Claire Deo EMBL Heidelberg Germany Gautam Dey EMBL Heidelberg Germany Alba Diz Mu oz EMBL Heidelberg Germany Jan Ellenberg EMBL Heidelberg Germany Anna Erzberger EMBL Heidelberg Germany Keisuke Goda Goda Lab Tokyo Japan Ralf Jungmann Max Planck Institute of Biochemistry Germany Simone Koehler EMBL Heildeberg Germany Anna Kreshuk EMBL Heidelberg Germany Kate McDole MRC Laboratory of Molecular Biology United Kingdom Rainer Pepperkok EMBL Heidelberg Germany Robert Prevedel EMBL Heidelberg Germany Thomas Quail EMBL Heidelberg Germany Jonas Ries Max Perutz labs Austria Yannick Schwab EMBL Heidelberg Germany Yi Sun EMBL Heidelberg Germany Alejandro Torres S nchez EMBL Barcelona Spain Virtual speaker Fiona Watt EMBL Heidelberg Germany Timo Zimmermann EMBL Heidelberg Germany Trainers LabPeopleBanterle GroupEnrico Salvatore Atorino EMBL Heidelberg GermanyAnna Lippert EMBL Heidelberg GermanyCuylen GroupBanafsheh Golchoubian EMBL Heidelberg GermanyYuki Hayashi EMBL Heidelberg GermanyDey GroupMargarida Araujo EMBL Heidelberg GermanyFelix Mikus EMBL Heidelberg GermanyHiral Shah EMBL Heidelberg GermanyDiz Mu oz GroupSrishti Dar EMBL Heidelberg GermanyLinda Decker EMBL Heidelberg GermanyFilipe Nunes Vicente EMBL Heidelberg GermanyEva Pillai EMBL Heidelberg GermanyRuben Tesoro Moreno EMBL Heidelberg GermanyEllenberg GroupHairuo Dang EMBL Heidelberg GermanyMarina Makharova EMBL Heidelberg GermanyKoki Watanabe EMBL Heidelberg GermanyErzberger GroupRoman Belousov EMBL Heidelberg GermanyJenna Elliott EMBL Heidelberg GermanyK hler GroupCristina Pineiro Lopez EMBL Heidelberg GermanyKreshuk GroupBenedikt Best EMBL Heidelberg GermanyDominik Kutra EMBL Heidelberg GermanyPepperkok TeamGeorge Galea EMBL Heidelberg GermanyMuzamil Majid Khan EMBL Heidelberg GermanyPrevedel GroupLing Wang EMBL Heidelberg GermanyQuail GroupShilpi Dhar EMBL Heidelberg GermanyNethaji Kuruppu EMBL Heidelberg GermanyNatalia Lopez EMBL Heidelberg GermanyJuliette Sebellin EMBL Heidelberg GermanySchwab TeamChandni Bhickta EMBL Heidelberg GermanyIn s Romero Brey EMBL Heidelberg GermanyWatt GroupAdil Boolani EMBL Heidelberg GermanyMirsana Ebrahim EMBL Heidelberg GermanyPurna Gadre EMBL Heidelberg GermanyPavlina Markova EMBL Heidelberg GermanyZimmermann TeamDietrich Walsh EMBL Heidelberg Germany Scientific organisers Niccol Banterle EMBL Heidelberg Germany Beth Cimini Broad Institute USA Simone Koehler EMBL Heidelberg Germany Course organisers Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Scientific Training Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBOCellBiology and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 1 September 2024 Time Europe Berlin SessionLocation15 30 16 00Registration and WelcomeISG Hotel16 00 16 30Welcome Safety introductionISG Hotel16 30 18 00Flash TalksISG Hotel18 00 18 45Challenges and ExpectationsISG Hotel18 45 19 00BreakISG Hotel19 00 20 00DinnerISG Hotel20 00 22 00Networking with DrinksISG Hotel Day 2 Monday 2 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 09 45Lecture Microscopy basicsRobert Prevedel EMBL Heidelberg GermanySeminar room 20209 45 10 15Break10 15 11 00Lecture Single molecule localization microscopy and MinfluxJonas Ries Max Perutz labs AustriaSeminar room 20211 00 14 00Poster session 1 odd numbers Lunch and open discussionOperon Foyer14 00 14 30Responsible Conduct of Research Practical 1Conducted by the respective trainers14 30 19 00Practical 1 parallel sessions 1 High speed AFM2 Using Expansion Microscopy in cell biology3 Dissecting the role of cell geometry in surface mechanics by combining micropatterning and AFM indentation4 Live imaging of mouse pre implantation embryos and bio image analysis5 Simultaneous labeling of DNA RNA and proteins preserving chromosome morphology Is that possible 6 Build your fluorescence microscope DIY 7 High Content Screening Investigating DNA damage response and inflammation interplay8 Random walks in Biology9 Characterizing stem cells from human epidermis10 Volume CLEM unravels the sub cellular architecture of selected marine unicellular plankton11 Fluorescence Lifetime Imaging Microscopy FLIM applications19 00 20 15DinnerEMBL Canteen20 15Return to hotelEMBL Bus Stop Day 3 Tuesday 3 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 09 45Lecture Biophysics of molecular sociologyThomas Quail EMBL Heidelberg GermanySeminar room 20209 45 10 15Break10 15 11 00Lecture Heterogeneity in human skin cellsFiona Watt EMBL Heidelberg GermanySeminar room 20211 00 14 00Poster session II even numbers Lunch and open discussionOperon Foyer14 00 19 00Practical I continue parallel sessions 1 High speed AFM2 Using Expansion Microscopy in cell biology3 Dissecting the role of cell geometry in surface mechanics by combining micropatterning and AFM indentation4 Live imaging of mouse pre implantation embryos and bio image analysis5 Simultaneous labeling of DNA RNA and proteins preserving chromosome morphology Is that possible 6 Build your fluorescence microscope DIY 7 High Content Screening Investigating DNA damage response and inflammation interplay8 Random walks in Biology9 Characterizing stem cells from human epidermis10 Volume CLEM unravels the sub cellular architecture of selected marine unicellular plankton11 Fluorescence Lifetime Imaging Microscopy FLIM applications19 00 20 30Tapas dinnerATC Rooftop Lounge20 30Return to hotelEMBL Bus Stop Day 4 Wednesday 4 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL bus stop08 55 09 00Overview of the daySeminar room 20209 00 09 45Lecture Super resolution microscopy introductionTimo Zimmermann EMBL Heidelberg GermanySeminar room 20209 45 10 10Break10 10 10 55Lecture Emerging model systems for cell biologyGautam Dey EMBL Heidelberg GermanySeminar room 20210 55 11 20Break11 20 12 05Lecture Cell mechanicsAlba Diz Mu oz EMBL Heidelberg GermanySeminar room 20212 05 12 55Lunch and NetworkingEMBL canteen12 55 13 15Responsible Conduct of Research Practical 2Conducted by the respective trainers13 15 17 45Practical 2 parallel sessions 1 High speed AFM2 Using Expansion Microscopy in cell biology3 Dissecting the role of cell geometry in surface mechanics by combining micropatterning and AFM indentation4 Live imaging of mouse pre implantation embryos and bio image analysis5 Simultaneous labeling of DNA RNA and proteins preserving chromosome morphology Is that possible 6 Build your fluorescence microscope DIY 7 High Content Screening Investigating DNA damage response and inflammation interplay8 Random walks in Biology9 Characterizing stem cells from human epidermis10 Volume CLEM unravels the sub cellular architecture of selected marine unicellular plankton11 Fluorescence Lifetime Imaging Microscopy FLIM applications17 45 18 45DinnerEMBL canteen18 45Walk to hotel Day 5 Thursday 5 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 10 00Seminar DNA PAINTRalf Jungmann Max Planck Institute of Biochemistry GermanySmall Operon10 00 10 30Meet the SpeakerSmall Operon10 30 11 00Break11 0 0 11 45Lecture Phase separation in cell biologySara Cuylen H ring EMBL Heidelberg GermanySeminar room 20211 45 12 45Career lunchEMBL canteen12 45 13 15Group Photo13 15 14 15Seminar Imaging the mammalian embryo with light sheet microscopy The director s cutKate McDole MRC Laboratory of Molecular Biology United KingdomSeminar room 20214 15 19 15Practical 2 continue parallel sessions 1 High speed AFM2 Using Expansion Microscopy in cell biology3 Dissecting the role of cell geometry in surface mechanics by combining micropatterning and AFM indentation4 Live imaging of mouse pre implantation embryos and bio image analysis5 Simultaneous labeling of DNA RNA and proteins preserving chromosome morphology Is that possible 6 Build your fluorescence microscope DIY 7 High Content Screening Investigating DNA damage response and inflammation interplay8 Random walks in Biology9 Characterizing stem cells from human epidermis10 Volume CLEM unravels the sub cellular architecture of selected marine unicellular plankton11 Fluorescence Lifetime Imaging Microscopy FLIM applications19 15 20 30Pizza DinnerATC Rooftop Lounge20 30Return to hotelEMBL Bus Stop Day 6 Friday 6 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 09 45Lecture TheoryAnna Erzberger EMBL Heidelberg GermanySeminar room 20209 45 10 15Break10 15 11 15Seminar SimulationsFlorian Berger Utrecht University The NetherlandsSmall Operon11 15 11 45Meet the SpeakerSeminar room 20211 45 12 45LunchEMBL canteen12 45 13 30Seminar Computational modellingAlejandro Torres S nchez EMBL Barcelona Spain virtual speaker Small Operon13 30 14 15Responsible Conduct of Research Practical 3Conducted by the respective trainersSeminar room 20214 15 18 45Practical 3 parallel sessions 1 High speed AFM2 Using Expansion Microscopy in cell biology3 Dissecting the role of cell geometry in surface mechanics by combining micropatterning and AFM indentation4 Live imaging of mouse pre implantation embryos and bio image analysis5 Simultaneous labeling of DNA RNA and proteins preserving chromosome morphology Is that possible 6 Build your fluorescence microscope DIY 7 High Content Screening Investigating DNA damage response and inflammation interplay8 Random walks in Biology9 Characterizing stem cells from human epidermis10 Volume CLEM unravels the sub cellular architecture of selected marine unicellular plankton11 Fluorescence Lifetime Imaging Microscopy FLIM applications18 45 19 00Return to hotelEMBL Bus Stop19 00 21 00Dinner and drinks at ISG HotelISG Hotel Day 7 Saturday 7 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 09 45Lecture Small molecule fluorophores for biological imagingClaire Deo EMBL Heidelberg GermanySeminar room 20209 45 10 00Break10 00 10 45Lecture Expansion microscopyNiccol Banterle EMBL Heidelberg GermanySeminar room 20210 45 11 00Break11 00 11 45Lecture MeiosisSimone K hler EMBL Heidelberg GermanySeminar room 20211 45 12 45LunchEMBL canteen12 45 18 00Practical 3 continue parallel sessions 1 High speed AFM2 Using Expansion Microscopy in cell biology3 Dissecting the role of cell geometry in surface mechanics by combining micropatterning and AFM indentation4 Live imaging of mouse pre implantation embryos and bio image analysis5 Simultaneous labeling of DNA RNA and proteins preserving chromosome morphology Is that possible 6 Build your fluorescence microscope DIY 7 High Content Screening Investigating DNA damage response and inflammation interplay8 Random walks in Biology9 Characterizing stem cells from human epidermis10 Volume CLEM unravels the sub cellular architecture of selected marine unicellular plankton11 Fluorescence Lifetime Imaging Microscopy FLIM applications18 00 18 30Bus to DowntownEMBL Bus Stop18 30 22 30Course dinner and Downtown Heidelberg visitFlammkuchenhof Heidelberg Day 8 Sunday 8 September 2024 Free day Day 9 Monday 9 September 2024 Time Europe Berlin SessionLocation08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 09 45Lecture Machine learning for image analysisAnna Kreshuk EMBL Heidelberg GermanySeminar room 20209 45 10 15Break10 15 11 15Seminar Cell ProfilerBeth Cimini Broad Institute of MIT and Harvard USASmall Operon11 15 11 45Meet the speakerSeminar room 20211 45 12 45LunchEMBL canteen12 45 13 30Lecture Correlative light electron microscopyYannick Schwab EMBL Heidelberg GermanySeminar room 20213 30 14 15Responsible Conduct of Research Practical 4 Image analysis and TheoryConducted by the respective trainers14 15 18 45Practical 4 Image analysis and Theory parallel sessions 1 Cell Profiler2 Image Processing Analysis with ilastik3 Mathematical modeling using random walksSeminar room 202 CTL Flexlab18 45 20 00DinnerEMBL canteen20 00Return to hotelEMBL Bus Stop Day 10 Tuesday 10 September 2024 Time Europe Berlin SessionSession08 40 08 55Bus from ISG hotel to EMBL Bus Stop08 55 09 00Overview of the daySeminar room 20209 00 10 00Seminar Cell sortingKeisuke Goda Goda Lab Tokyo JapanSmall Operon10 00 11 00Meet the speakerSeminar room 20211 00 11 30BreakSeminar room11 30 12 15Lecture Microscopy applied IJan Ellenberg EMBL Heidelberg GermanySeminar room 20212 15 13 15LunchEMBL canteen13 15 14 00Lecture TBCRainer Pepperkok EMBL Heidelberg GermanySeminar room 20214 00 14 45Responsible Conduct of Research Practical 5 Image analysis and TheoryConducted by the respective trainers14 45 19 15Practical 5 Image analysis and Theory parallel sessions 1 Cell Profiler2 Image Processing Analysis with ilastik3 Mathematical modeling using random walksSeminar room 202 CTL Flexlab19 15 19 45Feedback sessionSeminar room 20219 45 20 45DinnerEMBL canteen20 45Return to hotelEMBL Bus Stop Practical information Registration fees and motivation letter The course is limited to 30 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 1 to 10 September 10 nights In case you would like to have a single room please let the hotel know and note that you will be required to pay directly an additional cost of 24 per night availability of single rooms may be limited Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Niccolò Banterle, Beth Cimini, Simone Koehler

24 August - 27 August 2024

Transcription and chromatin

Description OverviewSpeakersFinal programmePractical informationSponsorsMedia kitPre conference workshop Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The EMBL Transcription and chromatin conference has a long standing tradition in shaping the field of transcriptional regulation The meeting brings together leading experts covering all aspects of transcription including cis regulatory function long range regulation 3 dimensional looping the basal transcriptional machinery RNA polymerase regulation and function nucleosome positioning chromatin modifications chromatin remodelling and epigenetic inheritance of transcriptional silencing The meeting contains many talks selected from the abstracts that are interspersed with invited speakers discussing the latest breakthroughs in transcriptional regulation The conference is designed to promote interactive discussions at both the talks and poster sessions Given the excellent lineup of speakers and the meeting s outstanding reputation this is a must attend for anyone interested in cutting edge research in transcription Topics General basal transcriptional machinery Pol II function pausing and the role of RNA in transcription Chromatin modifications and transcription Chromatin readers writers and epigenetic regulation Condensates hubs and speckles Transcription regulation during embryonic development and disease Genome topology and three dimensional regulation Quantatitive and theoretical approaches Imaging of transcription and genome What past participants say about the conference I would say that I am privileged to have been in the most prestigious institute on the planet It was my dream come true moment during the conference I sincerely thank EMBL for providing me conference registration grant otherwise it would never have been possible for me to reach EMBL I would urge every life sciences student to be at EMBL at least once it will be a lifetime experience for sure as it was for me Haneul Yoo Max Planck Institute of Immunobiology and Epigenetics Germany I am new to the field and attended the EMBL conference to meet people and learn about the field I learned a ton during the four days at the ATC and I also made new friends and contacts who I look forward to meeting again in future conferences Marion Turpin Institute Genetics Development of Rennes France A pleasure to attend my first EMBL Transcription and Chromatin conference Also very happy of having the opportunity to share my team s work networking and learning from incredible researchers in the field Elena G mez Mar n Andalusian Molecular Biology and Regenerative Medicine Centre Spain Speakers Karen Adelman Harvard Medical School USA Deborah Bourc his Institut Curie France Caroline Dean John Innes Centre UK Beat Fierz Ecole polytechnique f d rale de Lausanne Switzerland Thomas Gregor Princeton University USA Anja Groth University of Copenhagen Denmark Cigall Kadoch Dana Farber Cancer Institute and Harvard Medical School USA Gary Karpen University of California Berkeley USA Jop Kind Hubrecht Institute The Netherlands Mounia Lagha Institut de G n tique Mol culaire de Montpellier France Tineke Lenstra Netherlands Cancer Institute The Netherlands Karolin Luger University of Colorado Boulder USA Jan Michael Peters Research Institute of Molecular Pathology Austria Yang Shi Ludwig Cancer Research United Kingdom Ali Shilatifard Northwestern University Feinberg School of Medicine USA Bas van Steensel Netherlands Cancer Institute The Netherlands Peter Verrijzer Erasmus University Rotterdam The Netherlands Carl Wu Johns Hopkins University USA Joanna Wysocka Stanford University USA Yanhui Xu Fudan University China Yi Zhang Harvard University USA Scientific Organisers Shelley Berger University of Pennsylvania USA Eileen Furlong EMBL Heidelberg Germany Luca Giorgetti Friedrich Miescher Institute for Biomedical Research Switzerland J rg M ller Max Planck Institute of Biochemistry Germany Conference Organiser Nathalie Sneider EMBL Heidelberg Germany Final programme Are you on social media Post using EMBLTranscript and don t forget to tag EMBLEvents Please note that the programme is subject to change All talks are planned to take place on site only For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Recorded talks please note that for this event we expect 13 out of 21 invited speaker talks to be recorded and 21 out of 29 short talks to be recorded Details of which speaker talks will will not be available will be shown in the final programme when it is made available in mid August Please find the poster listing here Day 1 Saturday 24 August 2024 Time Europe Berlin Speaker14 30 16 30Arrival and registration15 00 15 50Pre conference workshop with LUMICKS16 30 16 40Opening remarks16 40 18 10Session 1Chairs Eileen Furlong EMBL Heidelberg Germany and J rg M ller Max Planck Institute of Biochemistry Germany16 40 17 00The rapidly expanding histone universeKarolin Luger University of Colorado Boulder and HHMI United States of America17 00 17 20Molecular insight into transcription elongation regulatory mechanisms and epigenetics deliver critical targets for cancer therapeuticsAli Shilatifard Northwestern University United States of AmericaNot available on demand17 20 17 35Structural basis of transcription and pausing by RNAPII in chromatinShun ichi Sekine RIKEN Japan17 35 17 50Single molecule dynamics of pioneer transcription factors interrogating chromatin in living cellsWulan Deng Peking University China17 50 18 10The epigenetic reader Phf2 is positioned in the genome by cohesinJan Michael Peters Research Institute of Molecular Pathology Austria18 10 19 45Dinner in the Canteen19 45 21 15Pub Quiz in the Canteen19 45 22 00After dinner drinks in the Rooftop Lounge and Foyer Day 2 Sunday 25 August 2024 Time Europe Berlin Speaker09 00 12 25Session 2Chairs Karolin Luger University of Colorado Boulder USA Peter Verrijzer Peter Verrijzer Erasmus University Rotterdam The Netherlands09 00 09 20Integrator mediated control of stress responsesKaren Adelman Harvard Medical School United States of AmericaNot available on demand09 20 09 35Structural basis of chromatin transcriptionLucas Farnung Harvard Medical School United States of AmericaNot available on demand09 35 09 50Direct recruitment of RNA Polymerase II by NANOG to chromatinNick Mullin The University of Edinburgh United Kingdom09 50 10 05Basal transcription factor TFIID in neurodevelopment and neurodegeneration Marc Timmers German Cancer Research Center DKFZ Germany10 05 10 25Structural Insights into Transcription InitiationYanhui Xu Fudan University China10 25 11 00Coffee Break11 00 11 20Dissecting the dynamics of coordinated active transcriptional repression in a multicellular organismMounia Lagha French National Centre for Scientific Research CNRS France11 20 11 35Chip ping away at zygotic genome activationCharalampos Galouzis EMBL Heidelberg Germany11 35 11 50HIV 1 promoter bursting in T lymphocytes and its implication in latency regulationEugenia Basyuk MFP UMR 5234 CNRS University of Bordeaux France11 50 12 05A conserved cis acting range extender element mediates extreme long range enhancer activity in mammalsGrace Bower University of California Irvine United States of America12 05 12 25Location location location Probing the functional landscape of a genomic locusBas van Steensel Oncode Institute Netherlands Cancer Institute The Netherlands12 25 14 00Lunch14 00 16 30Poster Session 1 odd with coffee and refreshments16 30 18 45Session 3Chaired by Yang Shi Ludwig Cancer Research United Kingdom Cigall Kadoch Dana Farber Cancer Institute and Harvard Medical School USA16 30 16 50The biogenesis dynamic maintenance and function of open chromatinCarl Wu Johns Hopkins University United States of America16 50 17 05Two distinct chromatin modules regulate 17proinflmmatory gene expressionKarsten Rippe German Cancer Research Center DKFZ Not available on demand17 05 17 20Long range TF co occupancy identifies functional dependencies between cis regulatory elementsArnaud Krebs EMBL Heidelberg Germany17 20 17 35The RNA binding protein Hangover associates with chromatin and regulates transcriptionAlexander Brehm Philipps University of Marburg Germany17 35 17 55A new spin to chromatin regulation of retrotransposonsD borah Bourc his Institut Curie France18 00 20 00Dinner in the Canteen20 00 22 00After dinner drinks in the Rooftop Lounge and Foyer Day 3 Monday 26 August 2025 Time Europe Berlin Speaker09 00 12 25Session 4Chaired by Karen Adelman Harvard Medical School USA Jan Michael Peters Research Institute of Molecular Pathology Austria09 00 09 20Chromatin replication and epigenome maintenanceAnja Groth Novo Nordisk Foundation Center for Protein Research University of Copenhagen DenmarkNot available on demand09 20 09 35Structural insight into the mechanisms of Polycomb Repressive Complex 1Maria Ciapponi Max Planck Institute of Biochemistry Germany09 35 09 50Chromatin tethering by the Trithorax homolog MLL2 during the ESC naive to primed transitionFrancis Stewart University of Cambridge United Kingdom09 50 10 05Molecular kinetics of transcription regulation during embryonic developmentMustafa Mir University of Pennsylvania United States of America10 05 10 25Imaging real time single molecule dynamics in genome regulationBeat Fierz cole Polytechnique F d rale de Lausanne EPFL SwitzerlandNot available on demand10 25 11 00Coffee Break11 00 11 20EMBO Young Investigator LectureTranscription factor exchange enables prolonged transcriptional burstsTineke Lenstra Netherlands Cancer Institute The Netherlands11 20 11 35Enhancer redundancy sustains transcriptional memories in metastatic cellsAlessio Zippo University of Trento Italy11 35 11 50Transient promoter interactions modulate developmental gene activationAngelika Feldmann German Cancer Research Center DKFZ GermanyNot available on demand11 50 12 05Enhancer cooperativity can compensate for loss of activity over large genomic distancesChrista Buecker Max Perutz Labs Vienna University of Vienna Austria12 05 12 25Spatial organization of a gene locus around transcription factor clusters in Drosophila embryosThomas Gregor Princeton University United States of America Institut Pasteur France12 25 14 00Vegetarian lunch and Meet the Editors between 13 00 14 00 in the FoyerChiara Anania and Hui Hua from Springer NatureEsther Schnapp and Hannah Sonntag from EMBO Lavinia Arseni from FEBS Letters14 00 16 30Poster Session 2 even with coffee and refreshments16 30 18 00Session 5Chaired by Gary Karpen University of California Berkeley USA Deborah Bourch has Institut Curie France16 30 16 50 Measuring single cell chromatin transitions in timeJop Kind Hubrecht Institute Royal Netherlands Academy of Arts and Sciences Oncode Institute University Medical Center Utrecht The Netherlands16 50 17 05Circadian rhythm tempers establishment of X chromosome inactivationMarnie Blewitt Walter and Eliza Hall Institute of Medical Research AustraliaNot available on demand17 05 17 20Functional redundancy and pathogenic mechanisms in RING1 and RNF2 variants Insights from H2AK119ub1 dosage in human neural developmentStephanie Bielas University of Michigan Medical School United States of America17 20 17 35Active state structures of the MSL reader writer complex reveal the molecular basis of histone H4K16 acetylationSebastian Eustermann EMBL Heidelberg Germany17 35 17 55Structure and Function of Mammalian SWI SNF Chromatin Remodeling Complexes in Health and DiseaseCigall Kadoch Dana Farber Cancer Institute Harvard Medical School United States of AmericaNot available on demand18 00 20 00Dinner in the Canteen20 00 22 00After dinner drinks in the Rooftop Lounge and Foyer Day 4 Tuesday 27 August 2024 Time Europe Berlin Speaker09 00 12 25Session 6Chaired by Anja Groth University of Copenhagen Denmark Ali Shilatifard Northwestern University Feinberg School of Medicine USA09 00 09 20Affinity hierarchies and amphiphilic proteins underlie the co assembly of nucleolar and heterochromatin condensatesGary Karpen University of California Berkeley United States of America09 20 09 35Elucidating the role of cohesin loop extrusion in transcriptional dynamics and enhancer promoter communicationKarissa Hansen University of California San Francisco United States of AmericaNot available on demand09 35 09 50Mechanisms of transcription control by distal enhancers from high resolution single gene imagingAlexandros Pertsinidis Memorial Sloan Kettering Cancer Center United States of America09 50 10 05Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long term memoryErica Korb University of Pennsylvania United States of America10 05 10 25Developmental stage specific functions and mechanisms of Polycomb silencingYi Zhang Boston Childrens Hospital United States of AmericaNot available on demand10 25 11 00Coffee Break11 00 11 20The tail wagging the dog function of the p53 IDR in target gene selectionPeter Verrijzer Erasmus University Medical Center The NetherlandsNot available on demand11 20 11 35Fueling memory the metabolic enzyme ACSS2 as a modulator of neuronal resilienceDesi Alexander Washington University School of Medicine in St Louis United States of America11 35 11 50Systematic assessment of ISWI subunits shows that NURF creates local accessibility for CTCFFrancesca Masoni Friedrich Miescher Institute for Biomedical Research SwitzerlandNot available on demand11 50 12 05Enhancer control of transcriptional activity via modulation of burst frequencyJana T nnermann Friedrich Miescher Institute for Biomedical Research Switzerland12 05 12 30Termination or read through co transcriptional processing linked to epigenetic silencingCaroline Dean John Innes Centre United Kingdom12 25 14 00Lunch14 00 16 30Poster Session 3 odd and even with coffee and refreshments16 30 19 00Session 7Chaired by Shelley Berger University of Pennsylvania USA Luca Giorgetti Friedrich Miescher Institute for Biomedical Research Switzerland16 30 16 50To be presented on siteYang Shi Ludwig Institute for Cancer Research Oxford University United KingdomNot available on demand16 50 17 05Sequence signature of evolutionary activation of distal regulatory elements in primate astrocytesAleksandra Pekowska Nencki Institute of Experimental Biology Polish Academy of Sciences Poland17 05 17 20Dynamic PRC1 CBX8 stabilizes a porous structure of chromatin condensatesChen Davidovich Monash University Australia17 20 17 35Transposons in 3D loop extrusion and compartmentalization affect the regulatory capacity of repeat elementsElzo de Wit The Netherlands Cancer Institute The Netherlands17 35 17 55How do transcription factors tolerate long polyglutamine tracts Joanna Wysocka Stanford University United States of AmericaNot available on demand17 55 18 10Closing remarks and poster prizes18 10 20 30Conference dinner in the Canteen20 30 23 30Conference party with live music from The Wright Thing Practical information Registration fees and abstract submission Late poster abstracts for this conference will still be considered Please contact nathalie sneider embl org if you are interested in presenting a poster On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 800On site PhD Student 700On site Industry 1000On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Nathalie Sneider for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Saturday 27 July 2024 in some cases at special rates Please email the hotel directly quoting the booking code TRM24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergHotel Bayrischer HofExzellenz Hotel Boarding HouseB B HotelHotel Holl nder HofHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the bus schedule here updated as of 26 August The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel front entrance View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Silver sponsor Bronze sponsor Event sponsors Active Motif GoodBot New England Biolabs NIPPON Genetics EUROPE Event supporter Media partners EMBO Journal an EMBO Press Journal Development The Company of Biologists Journal FEBS Letters FEBS Open Bio Genes and Development a Cold Spring Harbor Journal Genome Research a Cold Spring Harbor Journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering 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webinar will be hosted by our sponsor LUMICKS B V before the EMBL Conference Transcription and chromatin on Saturday 24 August 2024 15 00 16 00 Participation in this workshop is free of charge for registered on site conference attendees The workshop will take place in the Main Auditorium ABSTRACT Single molecule biology unravelling the mechanisms underlying chromatin organization and transcription Daphne Jurriens Roman Renger Ann MukhortavaLUMICKS B V Amsterdam The Netherlands The structure regulation maintenance and organization of chromatin is critical to cellular function Errors in the underlying molecular mechanisms have been shown to play a major role in diseases such as cancer Hence insights into the molecular details are needed to advance our understanding improve biological models and develop novel therapeutics Dynamic single molecule technologies offer an exciting opportunity to meet these challenges and to study protein dynamics function and activity in real time Here we present our efforts for enabling discoveries in chromatin and epigenetics research With the C TrapTM we provide an easy to use instrument that combines optical tweezers fluorescence microscopy and microfluidics It allows you to visualize the interaction and activity of individual protein complexes with and on chromatin in real time assemble chromatin structures in situ and to directly measure the mechanical forces that determine chromatin architecture We will cover several example studies in which our technology biochemistry and data analysis solutions have enhanced the understanding of fundamental processes of chromatin biology ranging from DNA damage repair to transcription to nucleosome remodeling Furthermore we will demonstrate how our platform can be utilized to assess the mechanical properties of individual chromatin fibers and complete chromosomes under various conditions related to physiology and disease...

Shelley Berger, Eileen Furlong, Luca Giorgetti, Jürg Müller

18 August - 26 August 2024

Advances in cryo-electron microscopy and 3D image processing

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Technology advances in cryo electron microscopy cryoEM over the last decade have transformed our understanding of biomolecular structures across different spatial scales CryoEM has unique capabilities for obtaining structural information in situ within complex cellular environments and to obtain atomic level structures of biologically flexible and heterogeneous macromolecular assemblies With the advent of the cryoEM resolution revolution the method has undergone a tremendous growth in user base Yet emerging breakthroughs such as new correlated imagine technologies and in AI based image processing demonstrate the potential for cryoEM to make another leap forward towards new frontiers Therefore in depth advanced training is essential to ensure future generations can adapt such emerging technologies to expand into new areas of biological research This course provides the theoretical and practical foundations of advanced cryoEM techniques from sample preparation to data collection to image processing Audience To meet the exceptional demand of the field for advanced training this course is aimed at PhD students and postdocs with basic experience in cryoEM and 3D image processing Modules resources During this course we will focus on the following aspects Single particle reconstruction cisTEM Relion cryoSPARC Subtomogram averaging Atomic models model building and integrative modeling Microscopy cryoEM ET and cryo FIB Latest developments in instrumentations Learning outcomes The course will enable participants to seamlessly integrate single particle analysis and tomography approaches to their cutting edge research disseminate their gained expertise to colleagues and eventually to innovate cryoEM methods beyond the state of the art What past participants say about the course This a world class course The access to experts and cutting edge techniques is incredible Corbin Black McGill University Canada This event has been granted the following EMBO sustainability badge Grade 2 of 3 The EMBL Imaging Centre training activities are generously supported by the Boehringer Ingelheim Foundation Speakers Speakers trainers and staff Tanmay Bharat MRC Laboratory of Molecular Biology UK Alister Burt Genentech USA Bridget Carragher Chan Zuckerberg Imaging Institute USA Virtual speaker Svetlana Dodonova EMBL Heidelberg Germany Johannes Elferich University of Massachusetts Medical School USA Sebastian Eustermann EMBL Heidelberg Germany Ryan Feathers Princeton University USA Simon Fromm EMBL Heidelberg Germany Robert Glaeser Lawrence Berkeley National Laboratory USA Virtual speaker Michal Grzadkowski Princeton University USA Nikolaus Grigorieff University of Massachusetts Medical School USA Hui Guo Max Planck Institute of Biochemistry Germany Thomas Hoffmann EMBL Heidelberg Germany Jan Kosinski EMBL Hamburg Germany Wanda Kukulski University of Bern Switzerland Julia Mahamid EMBL Heidelberg Germany Simone Mattei EMBL Heidelberg Germany Kyle Morris EMBL EBI UK Colin Palmer UKRI STFC UK Lori Passmore MRC Laboratory of Molecular Biology UK Cristina Paulino Heidelberg University Germany Rishwanth Raghu Princeton University USA Higor Rosa EMBL Heidelberg Germany Christopher Russo MRC Laboratory of Molecular Biology UK Carsten Sachse Forschungszentrum J lich Germany Sjors Scheres MRC Laboratory of Molecular Biology UK Virtual speaker Anna Steyer EMBL Heidelberg Germany Yi Sun EMBL Heidelberg Germany Dimitry Tegunov Genentech USA Beata Turonova Max Planck Institute of Biophysics Germany Virtual speaker Andriko von K gelgen MRC Laboratory of Molecular Biology UK Zhengyi Yang EMBL Heidelberg Germany Ellen Zhong Princeton University USA Virtual speaker Scientific Organisers Tanmay Bharat MRC Laboratory of Molecular Biology UK Sebastian Eustermann EMBL Heidelberg Germany Julia Mahamid EMBL Heidelberg Germany Simone Mattei EMBL Heidelberg Germany Lori Passmore MRC Laboratory of Molecular Biology UK Conference Organisers Ellen Malovrh EMBL Heidelberg Germany Irena Provaznikova Scientific Training Manager EMBL Heidelberg Germany Aline Cecilie Schnieder Course and Conference Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBOCryoEM and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Monday 8 July 2024 Time Europe Berlin ProgrammeLocation12 00 13 30Virtual onboarding session and introduction to EMBL e Campus and how to view recorded lecturesVirtual Day 1 Sunday 18 August2024 Time Europe BerlinProgrammeLocation15 00 15 40Registration and refreshmentsISG Hotel15 40 15 50Introduction and housenote slidesSebastian Eustermann EMBL Heidelberg GermanyISG Hotel15 50 16 00Course overviewISG Hotel16 00 17 00Student flash talksISG Hotel17 00 17 30Coffee breakISG Hotel17 30 18 30Student flash talksISG Hotel18 30 19 45Remote Lecture 1 Past and future of cryoEMRobert Glaeser Lawrence Berkeley National Laboratory USA virtual speaker ISG Hotel19 45 20 45DinnerISG Hotel Day 2 Monday 19 August 2024 Time Europe BerlinProgrammeLocation08 40 08 45Overview of the dayCourtyard Rooms08 45 09 05Industry talk Automation in cryo EM workflowsMaximilian Gemmer Thermo Fisher ScientificCourtyard Rooms09 05 10 20Lecture Cryo EM image formation and opticsChris Russo MRC Laboratory of Molecular Biology UKCourtyard Rooms10 20 10 50Coffee breakkindly sponsored by DECTRISCourtyard Rooms10 50 12 05Lecture Next generation microscope hardware Carsten Sachse Forschungszentrum J lich Germany Courtyard Rooms12 05 13 05Lunch breakEMBL Canteen13 05 14 20Remote Lecture Next generation cryoEM single particle sample preparation acquisitionKelly Nguyen MRC Laboratory of Molecular Biology UKCourtyard Rooms14 20 15 35Lecture cryoET sample preparation acquisitionJulia Mahamid EMBL Heidelberg GermanyCourtyard Rooms15 35 16 05Coffee breakkindly sponsored by DECTRISCourtyard Rooms16 05 17 20Remote Lecture Fundamentals in image processing Maximum likelihoodSjors Scheres MRC Laboratory of Molecular Biology UKCourtyard Rooms17 20 18 35EMBO Young Investigator Lecture Fundamentals in image processing cryoETTanmay Bharat MRC Laboratory of Molecular Biology UKCourtyard Rooms18 35 19 35DinnerEMBL Canteen Day 3 Tuesday 20 August 2024 Time Europe BerlinProgrammeLocation08 40 08 45Overview of the dayCourtyard Rooms08 45 09 05Industry talkAndrew Smith Kleindiek Nanotechnik GermanyCourtyard Rooms09 05 10 20Next generation High resolution by cryo ET subtomogram averagingDimitry Tegunov Genentech USACourtyard Rooms10 20 10 40Coffee breakkindly sponsored by DECTRISCourtyard Rooms10 40 11 55Next generation 2D template matching and beyondNikolaus Grigorieff University of Massachusetts Medical School USACourtyard Rooms11 55 12 25Panel discussion Hardware and sample preparationPanel leaders Simone Mattei and Julia Mahamid EMBL Heidelberg GermanyCourtyard Rooms12 25 13 25Lunch breakEMBL Canteen13 25 15 55Practical session ASession 1 on Advanced cryoEM single particle analysis RelionSPA topicSebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topicHui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topicTanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topicDimitry Tegunov Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validationColin Palmer UKRI STFC UKSession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room B15 55 16 25Coffee breakkindly sponsored by DECTRISCourtyard Rooms16 25 18 55Practical session BSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UKSession 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Colin Palmer UKRI STFC UKSession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room B18 55 19 55Canteen dinnerEMBL Canteen19 55 20 55Remote Lecture Hot topics recent breakthroughs and emerging technologiesBridget Carragher Chan Zuckerberg Imaging Institute USA Courtyard Rooms20 55 21 25Discussion round Hot topics recent breakthroughs and emerging technologiesCourtyard Rooms Day 4 Wednesday 21 August 2024 Time Europe BerlinProgrammeLocation09 00 09 05Overview of the dayCourtyard Rooms09 05 10 20Remote Lecture Advances in cryoET particle identificationBeata Turonova Max Planck Institute of Biophysics GermanyCourtyard Rooms10 20 10 40Coffee breakkindly sponsored by SubAngstromCourtyard Rooms10 40 11 55Lecture AI based methods Molecular heterogeneity landscapes from cryoEM and cryoETRishwanth Raghu Princeton University USACourtyard Rooms11 55 12 55Technology Lunch Complete CryoEM SolutionsMark Ebrahim SubAngstrom USARooftop Lounge12 55 13 25Panel discussion Software and image processingPanel leaders Sebastian Eustermann EMBL Heidelberg Germany and Tanmay Bharat MRC Laboratory of Molecular Biology UKCourtyard Rooms13 25 15 55Practical session CSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USASession 5 on Model building refinement and validation cont Colin Palmer UKRI STFC UKSession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room B15 55 16 25Coffee breakkindly sponsored by SubAngstromCourtyard Rooms16 25 18 55Practical session DSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAJoe Dobbs EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Colin Palmer UKRI STFC UKSession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room B18 55 19 55Pizza dinnerHelix B19 55 20 55Poster session with drinks 12 posters Helix B Day 5 Thursday 22 August 2024 Time Europe BerlinProgrammeLocation09 00 09 05Overview of the dayCourtyard Rooms09 05 10 05Lecture Next generation Atomic model building refinement and validationSebastian Eustermann EMBL Heidelberg GermanyCourtyard Rooms10 05 11 05Lecture Next generation integrative model buildingJan Kosinski EMBL Hamburg GermanyCourtyard Rooms11 05 11 35Coffee breakkindly sponsored by CEOS GmbHCourtyard Rooms11 35 12 35EMDB and EMPIAR Data repositoriesKyle Morris EMBL EBI UKCourtyard Rooms12 35 13 05Panel discussion Validation and FAIR dataPanel leader Lori Passmore MRC Laboratory of Molecular Biology UK and Sebastian Eustermann EMBL Heidelberg GermanyCourtyard Rooms13 05 14 05Technology Lunch Can aberration correctors help in cryo electron microscopy Heiko M ller CEOS Germany Rooftop Lounge14 05 16 35Practical session ESession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Colin Palmer UKRI STFC UKSession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USASession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B2816 35 17 05Coffee breakkindly sponsored by CEOS GmbHCourtyard Rooms17 05 19 35Practical session FSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Colin Palmer UKRI STFC UKSession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topicRyan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matchingNikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B2819 35 20 35DinnerEMBL Canteen20 35 21 35Poster session with drinks 12 posters Helix B Day 6 Friday 23 August 2024 Time Europe BerlinProgrammeLocation09 00 09 05Overview of the dayCourtyard Rooms09 05 10 20High Throughput and Resolution Data collectionSimone Mattei EMBL Heidelberg GermanyCourtyard Rooms10 20 11 35Correlative light and electron microscopy for Structural Cell BiologyWanda Kukulski University of Bern SwitzerlandCourtyard Rooms11 35 11 55Coffee breakkindly sponsored by SubAngstromCourtyard Rooms11 55 12 25Panel discussion Data acquisitionPanel leader Simone Mattei EMBL Heidelberg GermanyCourtyard Rooms12 25 13 25Lunch breakEMBL Canteen13 25 15 55Practical Session GSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Colin Palmer UKRI STFC UKSession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B2815 55 16 25Coffee breakkindly sponsored by SubAngstromCourtyard Rooms16 25 18 55Practical Session HSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement Colin Palmer UKRI STFC UKSession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B2818 55 19 55Dinner in EMBL CanteenEMBL Canteen19 55 20 25Lecture cryoEM careers in academia and pharmaDimitry Tegunov Genentech USACourtyard Rooms20 25 21 25Discussion round Career pathsCourtyard Rooms Day 7 Saturday 24 August 2024 Time Europe BerlinProgrammeLocation10 00 10 05Overview of the dayCourtyard Rooms10 05 12 05Practical Session I Drop in sessionSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 8 on Cryo TEMSimon Fromm EMBL Heidelberg GermanySession 9 on Cryo LMZhengyi Yang EMBL Heidelberg GermanySession 10 on HPF Waffle prepAnna Steyer EMBL Heidelberg GermanySession 11 on FIB SEMHigor Rosa EMBL Heidelberg GermanySession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B28Session 8 9 10 Imaging Center12 05 13 05Lunch breakEMBL Canteen13 05 15 05Practical Session J Drop in sessionSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Sebastian Eustermann EMBL Heidelberg GermanySession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 8 on Cryo TEMSimon Fromm EMBL Heidelberg GermanySession 9 on Cryo LMZhengyi Yang EMBL Heidelberg GermanySession 10 on HPF Waffle prepAnna Steyer EMBL Heidelberg GermanySession 11 on FIB SEMHigor Rosa EMBL Heidelberg GermanySession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B28Session 8 9 10 Imaging Center15 05 15 25Coffee breakCourtyard Rooms15 25 17 25Practical Session K Drop in sessionSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Sebastian Eustermann EMBL Heidelberg GermanySession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 8 on Cryo TEMSimon Fromm EMBL Heidelberg GermanySession 9 on Cryo LMZhengyi Yang EMBL Heidelberg GermanySession 10 on HPF Waffle prepAnna Steyer EMBL Heidelberg GermanySession 11 on FIB SEMHigor Rosa EMBL Heidelberg GermanySession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B28Session 8 9 10 Imaging Center17 25 19 25Free time downtown19 25 21 25Dinner in city centre Day 8 Sunday 25 August 2024 Time Europe BerlinProgrammeLocation10 00 10 05Overview of the dayCourtyard Rooms10 05 12 05Practical Session L Drop in sessionSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Sebastian Eustermann EMBL Heidelberg GermanySession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 8 on Cryo TEMSimon Fromm EMBL Heidelberg GermanySession 9 on Cryo LMZhengyi Yang EMBL Heidelberg GermanySession 10 on HPF Waffle prepAnna Steyer EMBL Heidelberg GermanySession 11 on FIB SEMHigor Rosa EMBL Heidelberg GermanySession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B28Session 8 9 Imaging Center12 05 13 05Lunch breakEMBL Canteen13 05 15 05Practical Session M Drop in sessionSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL GermanySession 5 on Model building refinement and validation cont Sebastian Eustermann EMBL Heidelberg GermanySession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 8 on Cryo TEMSimon Fromm EMBL Heidelberg GermanySession 9 on Cryo LMZhengyi Yang EMBL Heidelberg GermanySession 10 on HPF Waffle prepAnna Steyer EMBL Heidelberg GermanySession 11 on FIB SEMHigor Rosa EMBL Heidelberg GermanySession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B28Session 8 9 Imaging Center15 05 15 35Coffee breakCourtyard Rooms15 35 17 35Practical Session N Drop in sessionSession 1 on Advanced cryoEM single particle analysis RelionSPA topic cont Sebastian Eustermann EMBL Heidelberg GermanySession 2 on Advanced cryoEM single particle analysis cyroSPARC SPA topic cont Hui Guo Max Planck Institute of Biochemistry GermanySession 3 on Advanced cryoET subtomogram averaging Relion Tomo topic cont Tanmay Bharat MRC Laboratory of Molecular Biology UK Andriko von K gelgen MRC Laboratory of Molecular Biology UK Session 4 on Advanced cryoET subtomogram averaging WARP M Tomo topic cont Dimitry Tegunov Genentech USAAlister Burt Genentech USAJoe Dobbs EMBL Heidelberg GermanyRasmus Kjeldsen Jensen EMBL Heidelberg GermanySession 5 on Model building refinement and validation cont Sebastian Eustermann EMBL Heidelberg GermanySession 6 on Macromolecular Heterogeneity Analysis cryoDRGN topic cont Ryan Feathers Princeton University USARishwanth Raghu Princeton University USASession 7 2D template matching cont Nikolaus Grigorieff University of Massachusetts Medical School USAJohannes Elferich University of Massachusetts Medical School USASession 8 on Cryo TEMSimon Fromm EMBL Heidelberg GermanySession 9 on Cryo LMZhengyi Yang EMBL Heidelberg GermanySession 10 on HPF Waffle prepAnna Steyer EMBL Heidelberg GermanySession 11 on FIB SEMHigor Rosa EMBL Heidelberg GermanySession 1 Courtyard Rooms Session 2 Flex Lab BSession3 Flex Lab ASession 4 Computer Training LabSession 5 Helix Seminar Room BSession 6 B11 Session 7 B28Session 8 9 Imaging Center17 35 18 50Poster sessionHelix B18 50 19 50Canteen dinnerEMBL Canteen19 50 20 00Bus to ISG hotelATC Entrance20 00 21 00Lecture Future of cell structural biologyJulia Mahamid EMBL Heidelberg GermanyISG Hotel Day 9 Monday 26 August 2024 Time Europe BerlinProgrammeLocation08 40 08 45Overview of the dayCourtyard Rooms08 45 09 45Lecture Hot topics recent breakthroughs and emerging technologies in structural biology via cryoETSvetlana Dodonova EMBL Heidelberg GermanyCourtyard Rooms09 45 10 45Lecture Hot topics recent breakthroughs and emerging technologies in structural biology via cryoEMCristina Paulino Heidelberg University GermanyCourtyard Rooms10 45 11 15Coffee breakCourtyard Rooms11 15 12 15Wrap up practicals highlights presented by participantsCourtyard Rooms12 15 13 15Final panel discussion Wrap up with emphasis on the future of cryoEM responsible practice reporting and validation standardsCourtyard Rooms13 15 13 30Packed lunch and departureATC Entrance Practical information Registration fees and motivation letter The course is limited to up to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For more detailed information follow the instructions provided in our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events in Heidelberg and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO practical courses and workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a baby sitter or child care facility travel costs for a care giver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Accommodation in twin rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 18 to 26 8 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Imaging and Microscopy a Wiley magazine Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Julia Mahamid, Sebastian Eustermann, Simone Mattei, Lori Passmore, Henning Stahlberg

15 July - 19 July 2024

Proteomics bioinformatics

Description Thank you to those of you who have applied we have now selected our participants and wait list There are no more spaces available You can however register your interest for the 2025 course here This course provides hands on training in the basics of mass spectrometry MS and proteomics bioinformatics You will receive training on how to use search engines and post processing software quantitative approaches MS data repositories the use of public databases for protein analysis annotation of subsequent protein lists and incorporation of information from molecular interaction and pathway databases The practical elements of the course will take raw data from a proteomics experiment and analyse it You will be able to go from MS spectra to identifying and quantifying peptides and finally to obtaining lists of protein identifiers that can be analysed further using a wide range of resources The final aim is to provide you with the practical bioinformatics knowledge you need to go back to the lab and process your own data when collected This course is organised in association with the Vlaams Instituut voor Biotechnologie VIB the Flemish Institute for Biotechnology Pre recorded material may be provided before the course starts that you will need to watch read or work through to gain the most out of the actual training event In person courseThe course fee is inclusive of four nights of accommodation and catering including dinner We plan to deliver this course in person onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing...

Barbara Etzi

8 July - 9 July 2024

Hands-on Arthropod Bioinformatics Workshop

Description Join us for a 2 day workshop focused on hands on training on utilising web based data mining resources for arthropods Ensembl Metazoa and VectorBase to analyse both public and private datasets Omics data technologies allow scientists to analyse the genomes transcriptomes proteomes and genetic variability of arthropods These analyses enable the exploration of diverse research inquiries such as host pathogen interactions insecticide resistance diversity and many other aspects of behaviour biology and ecology In this workshop participants will learn to formulate testable hypotheses leveraging the power of these omics technologies To promote the accessibility and reuse of different data types numerous web based bioinformatics resources have been created Notably Ensembl and VectorBase stand out among a select group of essential resources for global research known as the Global Core Biodata Resources GCBRs and the Elixir Core Data Resources CDRs comprising only 31 and 37 members respectively As VectorBase is part of VEuPathDB insights gained can be extended to its other component sites encompassing parasites fungi and vertebrates Similarly within the Ensembl Genome project Ensembl Metazoa has the same type of tools and resources as Ensembl s sister sites...

Gloria I. Giraldo-Calderón

8 July - 12 July 2024

Time-resolved macromolecular serial crystallography

Description OverviewSpeakers and trainersProgrammePractical informationSponsorsMedia kit Overview Course overview The advent of serial crystallography at free electron laser sources and the following adaptation of these methods at 3rd and 4th generation synchrotrons have opened new possibilities to perform room temperature time resolved studies in macromolecular crystallography This course aims to train the next generation of researchers ini sample preparation Participants will be trained and taught in the best practice to obtain homogenous microcrystals and in characterisation prior to loading using different sample delivery methods ii crystal delivery methods and data collection at a 4th generation synchrotron serial crystallography beamline The new ID29 and similar endstations at other sources presents experimental setup and data collection protocols that are unique in the synchrotron facilities The training will include data collections with different sample delivery methods as available to the user community iii data reduction Diffraction data are recorded from still microcrystals with large bandwidth high flux X ray beams which requires the use of specifically developed and adapted software iv analysis of the electron density map differences To correctly interpret and model the electron density differences map to highlight structural changes induced by pump probe and ligand mixing experiments Audience The course is aimed at advanced PhD students and early career scientists working in X ray crystallography who have prior acquaintance of serial crystallography and willing to pursue projects requiring enzymatic reaction studies Moreover participants should clearly provide or show a direct intent of applying time resolved serial crystallography to their research projects In selecting participants we look for scientific merits in presenting their motivation immediate application of the methods learned strong background in understanding various aspects of crystallography basics and of studying enzymatic reactions As the course is to introduce participants to the forefront of structural biology big data analysis will be extensively carried out This would require background in basic programming or ability to use Linux command lines Modules Resources Micro crystallization strategies for soluble and membrane proteins Time resolved in crystallo spectroscopy to study reaction kinetics Tricks to run an injector based sample delivery for serial crystallography experiments Fixed target serial crystallography experiments Hands on experience on serial crystallography measurement at ID29 beamline Serial crystallography data analysis using latest softwares Time resolved data interpretation using real life cases Learning Outcomes Participants should be able to apply what they have learnt to their own projects For each module the participants will learn the theoretical and practical aspects of latest developments in the field After the course they will confidently be able to conduct a time resolved experiment to study enzymatic reactions Speakers and trainers John Beale Paul Scherrer Institute Switzerland James Beilsten Edmunds DLS Didcot UK Ashwin Chari Max Planck Institute Gottingen Germany Elke de Zitter IBS Grenoble France Sylvain Engilberge IBS grenoble France Petra Fromme Arizona State University USA Elspeth Garman University of Oxford UK Chia Ying Huang Swiss Light Source SLS Paul Scherrer Institute Switzerland Jose Martin Garcia Consejo Superior de Investigaciones Cient ficas Spain Pedram Mehrabi UHH Hamburg Germany Yvain Nicolet IBS Grenoble France Julien Orlans ESRF France Lars Redecke University of Lubeck Germany Alexandra Ros Arizona State University USA Antoine Royant IBS Grenoble France Monika Spano IBS Grenoble France Wiktor Szymanski University of Groningen Netherlands Sofia Trampari Dectris Switzerland Alexandra Tolstikova DESY Hamburg Germany Thomas White DESY Hamburg Germany Nadia Zatsepin Swinburne University Melbourne Australia Scientific organisers Oskar Aurelius MAX IV Laboratory Sweden Shibom Basu EMBL Grenoble France Gisela Br nd n University of Gothenburg Sweden Daniele de Sanctis ESRF France Arwen Pearson CFEL Hamburg Germany Course organisers Tracey Culloty EMBL Grenoble France Sophie Dutzi EMBL Heidelberg Germany Irena Provaznikova EMBL Heidelberg Germany Claudine Romero ESRF France Angelika Thomasson EMBL Grenoble France Programme Are you on social media Post using EMBOTRSX and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Please note the below programme is still subject to changes Day 0 Onboarding Monday 10 June 2024 Time Europe Berlin SessionLocation14 30 16 30Onboarding session access to eCampus learning platform introduction on Zoom introduction to the course materials to be used and expectations from the participants overview of the tools used during the courseEMBL eCampus Day 1 Monday 8 July 2024 Time Europe Berlin SessionLocation08 30 09 30Site entrance registration and Welcome coffee09 30 09 45Kick off note and course introductionESRF auditorium09 45 12 00Participants introduction Flash TalksESRF auditorium12 05 13 30Lunch EMBL ILL Hallway14 00 15 00Lecture 1 Serial crystallography brief history scientific significancePetra Fromme Arizona State University USAESRF auditorium15 00 16 00Lecture 2 Introduction to beamlines for serial crystallographyDaniele de Sanctis ESRF FranceESRF auditorium16 00 16 30Coffee breakkindly supported by DECTRISEMBL ILL Hallway16 30 17 15Lecture 3 Overview on X ray detector technology Sofia Trampari Dectris SwitzerlandESRF auditorium17 15 18 00Discussion on FAIR PracticeESRF auditorium18 00 19 00Poster sessionEMBL ILL Hall19 00 20 00DinnerEMBL ILL Hallway Day 2 Tuesday 9 July 2024 Time Europe Berlin SessionLocation09 00 09 05Overview of the day and Sample PreparationESRF auditorium09 05 09 30Lecture 4 What is a good sample Ashwin Chari Max Planck Institute Gottingen GermanyESRF auditorium09 30 09 55Lecture 5 How to grow microcrystalsJohn Beale Paul Scherrer Institute SwitzerlandESRF auditorium09 55 10 25Coffee breakEMBL ILL Hallway10 25 10 50Lecture 6 LCP crystallizationChia Ying Huang Swiss Light Source SLS Paul Scherrer Institute SwitzerlandESRF auditorium10 50 11 15Lecture 7 In vivo crystallizationLars Redecke University of Lubeck GermanyESRF auditorium11 15 11 40Lecture 8 Crystallization at anaerobic conditionYvain Nicolet IBS Grenoble FranceESRF auditorium11 40 12 05Lecture 9 TR icOS spectroscopyAntoine Royant IBS Grenoble FranceESRF auditorium12 10 13 30LunchEMBL ILL Hallway13 30 16 00Practical Session 1Practical sessions in different groupsMeeting point EMBL ILL Hallway16 00 16 30Coffee breakEMBL ILL Hallway16 30 19 00Practical Session 1 continuedPractical sessions in different groupsMeeting point EMBL ILL Hallway19 00 20 30DinnerBouillon Day 3 Wednesday 10 July 2024 Time Europe Berlin SessionLocation09 00 09 05Overview of the day Sample delivery data collectionESRF auditorium09 05 09 30Lecture 10 Delivery using injectorsJulien Orlans ESRF FranceESRF auditorium09 30 09 55Lecture 11 Delivery using injectors and tape drivesPedram Mehrabi UHH Hamburg GermanyESRF auditorium09 55 10 25Coffee breakEMBL ILL Hallway10 25 10 50Lecture 12 Mixing and microfluidicsAlexandra Ros Arizona State University USAESRF auditorium10 50 11 15Lecture 13 Best practice for time resolved experimentsArwen Pearson CFEL Hamburg GermanyESRF auditorium11 15 11 40Lecture 14 Laser activation for time resolved experimentsWiktor Szymanski University of Groningen NetherlandsESRF auditorium11 40 12 05Lecture 15 Serial crystallography theory and statistics data qualityNadia Zatsepin Swinburne University Melbourne AustraliaESRF auditorium12 05 13 30LunchEMBL ILL Hallway13 30 16 00Practical Session 2Practical sessions in different groupsMeeting point EMBL ILL Hallway16 00 16 30Coffee breakEMBL ILL Hallway16 30 19 00Practical Session 2 continuedPractical sessions in different groupsMeeting point EMBL ILL Hallway19 00 Free evening Day 4 Thursday 11 July 2024 Time Europe Berlin SessionLocation09 00 09 05Overview of the day Serial crystallographic data processingESRF auditorium09 05 09 30Lecture 16 Pink beam time resolved serial crystallographyAlexandra Tolstikova DESY CFEL Hamburg GermanyESRF auditorium09 30 09 55Lecture 17 CrystFEL best practiceThomas White DESY CFEL Hamburg GermanyESRF auditorium09 55 10 25Coffee breakESRF lobby10 25 10 50Lecture 18 Dials cctbx xfel XIA2James Beilsten Edmands DLS Didcot UKESRF auditorium10 50 11 15Lecture 19 Interpretation calculation of Difference electron density mapElke de Zitter IBS Grenoble FranceESRF auditorium11 15 12 05Lecture 20 Paying attention to radiation damage in serial dataElspeth Garman University of Oxford UKESRF auditorium12 05 13 30LunchEMBL ILL Hallway13 30 15 30Practical Session 3 Practical sessions in different groupsMeeting point CIBB Seminar room at EMBL ILL Hall15 30 16 00Coffee breakEMBL ILL Hallway16 00 18 30Practical Session 3 continuedPractical sessions in different groupsMeeting point CIBB Seminar room at EMBL ILL Hall19 00 19 15Meeting at site entry to depart for Gala DinnerSite entryGala dinner at Chateau de la commanderie Day 5 Friday 12 July 2024 Time Europe Berlin SessionLocation09 00 09 05Overview of the day Group activityESRF auditorium09 05 10 50Brainstorming Participant groups will work on ideas powerpointESRF auditorium10 50 11 10Coffee breakEMBL ILL Hallway11 10 11 40Course EvaluationESRF auditorium11 40 12 05Closing RemarkESRF auditorium12 05 13 30Lunch and DepartureEMBL ILL Hallway Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include accommodation location TBC all meals throughout the duration of the course admission and course materials Travel expenses are NOT covered with the registration fee Academia 425PhD Student 425Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accomodation and further details Hotel Reservations have been made for course participants at the guesthouse located in the EPN campus which hosts the EMBL Grenoble site as well as at the residence S jour Affaires Marie Curie More details will be available soon Note accommodation is included in the registration fee Further details Address EMBL Grenoble 71 Av des Martyrs 38000 Grenoble FranceFrom Lyon Saint Exup ry Airport take the airport shuttle bus Lyon Saint Exup ry Grenoble counter Satobus inside the airport or in the bus A single ticket costs 22 a return ticket 33 The stop Place de la R sistance is within easy walking distance of the EMBL site From Grenoble take Tram B towards Resistance roundabout and exit at Grenoble Presquile The site entry is 350m away from the stop For further information on getting to EMBL Grenoble visit our Travel Information page Technical requirements and event software Technical requirements Information will be provided ahead of the course about installing any software required Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus At the mandatory on boarding session on Wednesday 5 June the functionalities of the platform and course content will be further explained Technical requirements All participants must bring their own laptops COVID 19 related questions Updated information will be provided closer to the time of the on site module Sponsors Event sponsors Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Oskar Aurelius, Shibom Basu, Gisela Brändé, Arwen Pearson, Daniele de Sanctis

8 July - 13 July 2024

Time-resolved STED nanoscopy in life sciences

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This six day comprehensive advanced microscopy course focuses on stimulated emission depletion microscopy STED and its application to biological questions Through lectures tutorials and practical workshops the course provides in depth knowledge on all aspects of STED Nanoscopy It covers the fundamentals of STED microscopy different technical implementations and has a strong emphasis on sample preparation including choice of fluorophores and refractive index matching as well as image acquisition strategies for fixed samples and living cells Students will have the opportunity for exercises on state of the art STED microscopes in which they will acquire high quality nanoscopy data The faculty consists of invited guest researchers experts from the EMBL and Leica Microsystems Audience This course is designed for researchers at the early stages of their career in the life sciences e g pre or postdoctoral level ideally with access to a STED microscope The participants should have an immediate need to apply the trained skills for their biological questions The course is strongly centered on practical aspects of STED microscopy and is therefore especially suited for people who rely on STED nanoscopy for their research Modules Resources The course will cover the entire range of skills needed to apply STED nanoscopy in life sciences The following topics will be covered in lectures tutorials as well as in practical workshops Sample preparation for STED microscopy including choice of fluorophores and refractive index matching Technical implementations pulsed STED gated STED and time resolved STED tauSTED Multi colour 2D and 3D STED microscopy Image acquisition strategies for live cell STED STED multiplexing via lifetime based fluorophore separation Clearing for large volume STED imaging Expansion microscopy STED Deconvolution of time resolved STED data Image analysis Learning Outcomes At the end of the course the participants will be able to design experiments using STED microscopy prepare high quality microscopy samples and acquire state of the art nanoscopy images This course is organised in cooperation with Leica Microsystems What past participants say about the course The EMBL super resolution microscopy course was exactly tailored to my needs and will allow me to get my own experiments running independently Also contacts I made will be very useful in the future Paul Markus M ller Freie Universit t Berlin Germany Very well organized and conceived course Everything is covered here including thefundamentals the practical sessions creative application innovative development of STED technology If you are interested in the nanoscopy I would recommend you to participate in this course Shao Chun Peggy Hsu National Taiwan University Taiwan Speakers Speakers trainers and staff Sophie Allart Toulouse Institute for Infectious and Inflammatory Diseases France Luis Alvarez Leica Microsystems CMS GmbH Germany Niccolo Banterle EMBL Heidelberg Germany Ana Rita Costa I3S Portugal Jana D hner Center for Microscopy and Image Analysis Switzerland Michaela Frolikova Institute of Biotechnology CAS v v i BIOCEV Czech Republic Dorus Gadella Swammerdam Institute for Life Sciences The Netherlands Mariano Gonzalez Pisfil Biomedical Center Ludwig Maximilians Universit t Germany Magali Grison CNRS Bordeaux France Kai Johnson Max Planck Institute for Medical Research Germany Julian Kompa Max Planck Institute for Medical Research Germany Ivana Nikic Spiegel Centre for Integrative Neuroscience CIN Germany Christel Poujol CNRS Bordeaux France Arina Rybina EMBL Heidelberg Germany Ulf Schwarz Leica Microsystems CMS GmbH Germany Till Stephan Max Planck Institute for Biophysical Chemistry Clinic of Neurology University Medical Center Germany Scientific organisers Manuel Gunkel EMBL Heidelberg Germany Marko Lampe EMBL Heidelberg Germany Andrea M lter Leica Microsystems CMS GmbH Germany Julia Roberti Leica Microsystems CMS GmbH Germany Course organisers Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLSuperResolution and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 8 July 2024 Time Europe Berlin SpeakerLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel08 55 09 15Registration Welcome EMBL Imaging Centre09 15 10 00Lecture 1 Overview of Super resolution Microscopy TechniquesMarko Lampe EMBL Heidelberg GermanyEMBL Imaging Centre10 00 10 45Lecture 2 Introduction to lifetime based STED MicroscopyUlf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre10 45 11 00Coffee BreakEMBL Imaging Centre11 00 12 15Flash Talks 1EMBL Imaging Centre12 15 13 15LunchEMBL Canteen13 15 14 00Flash Talks 2EMBL Imaging Centre14 00 16 00Practical 1 Group 1 Introduction Single Multicolor 2D 3D STED fixed thin samplesJana D hner ZMB UZH Z rich SwitzerlandPractical 2 Group 2 Clearing Large Volume 3D STEDDavid Unnersj Jess KTH Royal Institute of Technology SwedenPractical 3 Group 3 Gentle Live Cell Imaging FPsLuis Alvarez Leica Microsystems CMS GmbH GermanyPractical 4 Group 4 TauSTED XTEND optimizing parameters Computer Training Lab Ulf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre16 00 16 30Coffee breakEMBL Imaging Centre16 30 18 30Practical 1 Group 2 Intro Single Multicolor 2D 3D STED fixed thin samplesJana D hner ZMB UZH Z rich SwitzerlandPractical 2 Group 3 Clearing Large Volume 3D STEDDavid Unnersj Jess KTH Royal Institute of Technology SwedPractical 3 Group 4 Gentle Live Cell Imaging FPsLuis Alvarez Leica Microsystems CMS GmbH GermanyPractical 4 Group 1 TauSTED XTEND optimizing parameters Computer Training Lab Ulf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre18 30 19 30DinnerEMBL Canteen19 30Departure to HotelATC Entrance Day 2 Tuesday 9 July 2024 Time Europe Berlin SpeakerLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayEMBL Imaging Centre09 05 09 50Lecture 3 2D STED to study the nanoscale organization of an integrin at the CD8 T lymphocyte synapseSophie Allart Toulouse Institute for Infectious and Inflammatory Diseases FranceEMBL Imaging Centre09 50 10 35Lecture 4 TBCKai Johnson Max Planck Institute for Medical Research GermanyEMBL Imaging Centre10 35 10 50Coffee BreakEMBL Imaging Centre10 50 11 35Lecture 5 Fluorescent Protein Optimisation by Multiparameter ScreeningDorus Gadella Swammerdam Institute for Life Sciences The NetherlandsEMBL Imaging Centre11 35 12 20Lecture 6 TauSTED Xtend a new approach for even more gentle live imagingJulia Roberti Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre12 20 13 35LunchEMBL Canteen13 35 15 35Practical 1 Group 3 Intro Single Multicolor 2D 3D STED fixed thin samplesJana D hner ZMB UZH Z rich SwitzerlandPractical 2 Group 4 Clearing Large Volume 3D STEDDavid Unnersj Jess KTH Royal Institute of Technology SwedenPractical 3 Group 1 Gentle Live Cell Imaging FPsLuis Alvarez Leica Microsystems CMS GmbH GermanyPractical 4 Group 2 TauSTED XTEND optimizing parameters Computer Training Lab Ulf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre15 35 16 05Coffee breakEMBL Imaging Centre16 05 18 05Practical 1 Group 4 Intro Single Multicolor 2D 3D STED fixed thin samplesJana D hner ZMB UZH Z rich SwitzerlandPractical 2 Group 1 Clearing Large Volume 3D STEDDavid Unnersj Jess KTH Royal Institute of Technology SwedenPractical 3 Group 2 Gentle Live Cell Imaging FPsLuis Alvarez Leica Microsystems CMS GmbH GermanyPractical 4 Group 3 TauSTED XTEND optimizing parameters Computer Training Ulf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre18 05 19 05DinnerEMBL Canteen19 05Departure to HotelATC Entrance Day 3 Wednesday 10 July 2024 Time Europe Berlin SpeakerLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayEMBL Imaging Centre09 05 09 50Lecture 7 ER to Golgi trafficking via a dynamic intermediate cis Golgi tubular network in ArabidopsisMagali Grison CNRS Bordeaux FranceEMBL Imaging Centre09 50 10 35Lecture 8 Combining STED and expansion microscopy an easy way towards molecular resolutionNiccolo Banterle EMBL Heidelberg GermanyEMBL Imaging Centre10 35 10 50Coffee BreakEMBL Imaging Centre10 50 11 35Lecture 9 Investigating the structure and dynamics of mitochondria at the nanoscaleTill Stephan Max Planck Institute for Biophysical Chemistry Clinic of Neurology University Medical Center GermanyEMBL Imaging Centre11 35 12 20Lecture 10 STED microscopy with a single depletion laser using five fluorochromes and fluorescence lifetime phasor separationMariano Gonzalez Pisfil Biomedical CenterMunich GermanyEMBL Imaging Centre12 20 13 20LunchEMBL Canteen13 20 13 35Group PhotoEMBL Imaging Centre13 35 15 35Practical 5 Group 1 STED microscopy to resolve the organization of the Golgi apparatus in plant samplesMagali Grison CNRS Bordeaux FranceChristel Poujol CNRS Bordeaux FrancePractical 6 Group 2 ExM STEDNiccolo Banterle EMBL Heidelberg GermanyPractical 7 Group 3 Live cell STED microscopy of cell organellesTill Stephan Max Planck Institute for Biophysical Chemistry Clinic of Neurology University Medical Center GermanyPractical 8 Group 4 Phasor based separation multicolor Imaging CLSM STED Computer Training Lab Mariano Gonzalez Pisfil Biomedical CenterMunich GermanyEMBL Imaging Centre15 35 16 05Coffee breakEMBL Imaging Centre16 05 18 05Practical 5 Group 2 STED microscopy to resolve the organization of the Golgi apparatus in plant samplesMagali Grison CNRS Bordeaux FranceChristel Poujol CNRS Bordeaux FrancePractical 6 Group 3 ExM STEDNiccolo Banterle EMBL Heidelberg GermanyPractical 7 Group 4 Live cell STED microscopy of cell organellesTill Stephan Max Planck Institute for Biophysical Chemistry Clinic of Neurology University Medical Center GermanyPractical 8 Group 1 Phasor based separation multicolor Imaging CLSM STED Computer Training Lab Mariano Gonzalez Pisfil Biomedical CenterMunich GermanyEMBL Imaging Centre18 05 19 05DinnerEMBL Canteen19 05Departure to HotelATC Entrance Day 4 Thursday 11 July 2024 Time Europe Berlin SpeakerLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayEMBL Imaging Centre09 05 09 50Lecture 11 Beyond limits super resolution microscopy and its impact on understanding the axonal MPSAna Rita Costa I3S PortugalEMBL Imaging Centre09 50 10 35Lecture 12 Minimal click chemistry based genetically encoded tags for fluorescent protein labeling in living cellsIvana Nikic Spiegel Centre for Integrative Neuroscience CIN GermanyEMBL Imaging Centre10 35 10 50Coffee BreakEMBL Imaging Centre10 50 11 35Lecture 13 Capturing the Entire Oocyte with 3D STED Microscopy Investigating Juno and CD9 Protein Organization in OolemmaMichaela Frolikova Institute of Biotechnology CAS BIOCEVLaboratory of Reproductive Biology Czech RepublicEMBL Imaging Centre11 35 12 20Lecture 14 Navigating the complexities of sample preparation for high resolution microscopy from fixation to fluorophore selectionJana D hner ZMB UZH Z rich SwitzerlandEMBL Imaging Centre12 20 13 35LunchEMBL Canteen13 35 15 35Practical 5 Group 3 STED microscopy to resolve the organization of the Golgi apparatus in plant samplesMagali Grison CNRS Bordeaux FranceChristel Poujol CNRS Bordeaux FrancePractical 6 Group 4 ExM STEDNiccolo Banterle EMBL Heidelberg GermanyPractical 7 Group 1 Live cell STED microscopy of cell organellesTill Stephan Max Planck Institute for Biophysical Chemistry Clinic of Neurology University Medical Center GermanyPractical 8 Group 2 Phasor based separation multicolor Imaging CLSM STED Computer Training Lab Mariano Gonzalez Pisfil Biomedical Centerm Munich GermanyEMBL Imaging Centre15 35 16 05Coffee breakEMBL Imaging Centre16 05 18 05Practical 5 Group 4 STED microscopy to resolve the organization of the Golgi apparatus in plant samplesMagali Grison CNRS Bordeaux FranceChristel Poujol CNRS Bordeaux FrancePractical 6 Group 1 ExM STEDNiccolo Banterle EMBL Heidelberg GermanyPractical 7 Group 2 Live cell STED microscopy of cell organellesTill Stephan Max Planck Institute for Biophysical Chemistry Clinic of Neurology University Medical Center GermanyPractical 8 Group 3 Phasor based separation multicolor Imaging CLSM STED Computer Training Lab Mariano Gonzalez Pisfil Biomedical Centerm Munich GermanyEMBL Imaging Centre18 05 19 00Bus Downtown with a stop at ISG Hotel ATC Entrance19 00 21 30Downtown DinnerOskar Vinothek and Restaurant Day 5 Friday 12 July 2024 Time Europe Berlin SpeakerLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayEMBL Imaging Centre09 05 09 50Lecture 15 Live Cell STED Imaging using exchangeable HaloTag LigandsJulian Kompa Max Planck Institute for Medical Research GermanyEMBL Imaging Centre09 50 10 35Lecture 16 TBCDavid Unnersj Jess KTH Royal Institute of Technology SwedenEMBL Imaging Centre10 35 10 50Coffee BreakEMBL Imaging Centre10 50 11 10Lecture 17 Euro BioImaging ERIC Opportunities for Open Access to Imaging technologies expertise across scalesArina Rybina EMBL Heidelberg GermanyEMBL Imaging Centre11 10 12 00Visit to The World of Molecular Biology ExhibitionEMBL Imaging Centre12 00 13 15LunchEMBL Canteen13 15 15 15Practical 9 Group 1 Working Title Live Cell Imaging using exchangeable HaloTagsJulian Kompa Max Planck Institute for Medical Research GermanyPractical 10 Group 2 Multicolor STED with a single depletion line fixed samplesMariano Gonzalez Pisfil Biomedical CenterMunich Germany Practical 11 Group 3 Imaging of Fixed samples Exchangeable dyesMarko Lampe EMBL Heidelberg GermanyPractical 12 Group 4 Image analysis FiJi Computer Training Lab Manuel Gunkel EMBL Heidelberg GermanyEMBL Imaging Centre15 15 15 45Coffee breakEMBL Imaging Centre15 45 17 45Practical 9 Group 2 Working Title Live Cell Imaging using exchangeable HaloTagsJulian Kompa Max Planck Institute for Medical Research GermanyPractical 10 Group 3 Multicolor STED with a single depletion line fixed samplesMariano Gonzalez Pisfil Biomedical CenterMunich GermanyPractical 11 Group 4 Imaging of Fixed samples Exchangeable dyesMarko Lampe EMBL Heidelberg GermanyPractical 12 Group 1 Image analysis FiJi Computer Training Lab Manuel Gunkel EMBL Heidelberg GermanyEMBL Imaging Centre17 45 18 45DinnerEMBL Canteen18 45Departure to HotelATC Entrance Day 6 Saturday 13 July 2024 Time Europe Berlin SpeakerLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayEMBL Imaging Centre09 05 09 50Lecture 19 Tutorial Optics and Refractive Index MatchingUlf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre09 50 10 00Coffee BreakEMBL Imaging Centre10 00 12 00Practical 9 Group 3 Working Title Live Cell Imaging using exchangeable HaloTagsJulian Kompa Max Planck Institute for Medical Research GermanyPractical 10 Group 4 Multicolor STED with a single depletion line fixed samplesMariano Gonzalez Pisfil Biomedical CenterMunich GermanyPractical 11 Group 1 Imaging of Fixed samples Exchangeable dyesMarko Lampe EMBL Heidelberg GermanyPractical 12 Group 2 Image analysis FiJi Computer Training Lab Manuel Gunkel EMBL Heidelberg GermanyEMBL Imaging Centre12 00 13 00LunchEMBL Canteen13 00 15 00Practical 9 Group 4 Working Title Live Cell Imaging using exchangeable HaloTagsJulian Kompa Max Planck Institute for Medical Research GermanyPractical 10 Group 1 Multicolor STED with a single depletion line fixed samplesMariano Gonzalez Pisfil Biomedical CenterMunich GermanyPractical 11 Group 2 Imaging of Fixed samples Exchangeable dyesMarko Lampe EMBL Heidelberg GermanyPractical 12 Group 3 Image analysis FiJi Computer Training Lab Manuel Gunkel EMBL Heidelberg GermanyEMBL Imaging Centre15 00 16 00Feedback FarewellEMBL Imaging Centre16 00Bus to ISG Hotel Heidelberg train station and city centerATC Entrance Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 525PhD Student 525Industry 1025 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights 7 13 July 2024 at ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code MIC24 03 by the deadline of 10 Jube 2024 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Imaging and Microscopy a Wiley magazine Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Marko Lampe, Andrea Mülter, Manuel Gunkel, Julia Roberti

4 July - 5 July 2024

From atoms to ecosystems – a new era in life sciences

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview The symposium will take place at EMBL Heidelberg Registration for the onsite event is now closed EMBL staff and alumni can join a waiting list via the link being circulated internally and in EMBL s alumni network Late virtual registration are still open to all by 3 July 2024 To take part in the symposium virtually please register via the button on this page Registration is free of charge Conference overview In 2024 EMBL will celebrate its 50th anniversary with a historic two day scientific symposium This colloquium From atoms to ecosystems a new era in life sciences will be held both virtually and in person at Heidelberg on Thursday 4 Friday 5 July 2024 The event will celebrate EMBL from the moment of its inception in 1974 when the proposal to bring a world class life sciences laboratory to Europe was ratified through to the exciting and vibrant organisation that EMBL represents today The symposium will explore the foundational scientific research service technology and innovation that EMBL has fostered over the past 50 years It will showcase EMBL s inspiring and pioneering scientific contributions and highlight how these still continue to evolve to address topics of global importance The programme will encompass both a historic perspective and a forward look to the cutting edge science that EMBL is bringing to the life sciences of the future The symposium sessions will include presentations from current and former EMBL group leaders as well as former EMBL pre and postdoctoral fellows The first day will be focused on research from cells to tissues spanning genome biology developmental biology as well as protein structures and complexes The second day will focus on digital biology and the current EMBL research programme Molecules to Ecosystems as well as technological advances past and present The symposium will conclude with a panel on The past the present and the future A discussion with EMBL s global community Session topics Genome biology Protein structures and complexes From cells to tissues Developmental biology Molecules to ecosystems Bioinformatics EMBL s technology highlights Alumni celebrating EMBL and its community Speakers Speakers Martin Beck Max Planck Institute of Biophysics Germany Peter Becker Ludwig Maximilians University Germany Isidro Cortes Ciriano EMBL EBI UK Patrick Cramer President of the Max Planck Society Germany Miki Ebisuya Physics of Life TU Dresden Germany EMBL Barcelona Spain Thomas Graf Centre for Genomic Regulation CRG Spain Valentina Greco Yale University USA Jamie Hackett EMBL Rome Italy Val rie Hilgers Max Planck Institute of Immunobiology and Epigenetics Germany Jan Huisken Georg August University G ttingen Germany Anthony Hyman Max Planck Institute of Molecular Cell Biology and Genetics Germany Aissam Ikmi EMBL Heidelberg Germany Eric Karsenti Tara Oceans France EMBL Heidelberg Germany Julia Mahamid EMBL Heidelberg Germany Mikhail Savitski EMBL Heidelberg Germany Janet Thornton EMBL EBI UK Pavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany Maria Tosches Columbia University USA Lara Urban Helmholtz AI Helmholtz Pioneer Campus Germany Alfonso Valencia Barcelona Supercomputing Center Spain Jordi van Gestel EMBL Heidelberg Germany Panelists Ana Boskovic EMBL Rome Italy Edith Heard EMBL Heidelberg Germany Jan Kosinski EMBL Hamburg Germany Christiane N sslein Volhard Max Planck Institute for Biology T bingen Germany Paul Nurse The Francis Crick institute UK Oliver Stegle EMBL Heidelberg DKFZ Germany Flora Vincent EMBL Heidelberg Germany Scientific organisers Rolf Apweiler EMBL EBI UK Elena Conti Max Planck Institute of Biochemistry Germany Anne Ephrussi EMBL Heidelberg Germany Eileen Furlong EMBL Heidelberg Germany Cornelius Gross EMBL Rome Italy Rainer Pepperkok EMBL Heidelberg Germany Pavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germany Nassos Typas EMBL Heidelberg Germany Conference organisers Catherine Casas EMBL Heidelberg Germany Charlotte Courtney EMBL Heidelberg Germany J rgen Deka EMBL Heidelberg Germany Lea Hohmann EMBL Heidelberg Germany Programme Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Thursday 4 July 2024 Times Berlin Europe Speakers08 00 09 30Registration and coffee EMBL conference shuttle bus schedule 09 30 09 45Opening remarks Prof Edith HeardWith a video message from Federal Minister Bettina Stark Watzinger German Federal Minister of Education and Research09 45 11 15Session 1 Genome biologyChairs Eileen Furlong Ewan Birney09 45 10 15Former EMBL group leader Male specific lethality in flies from phenomenon to mechanismPeter Becker Ludwig Maximilians University Germanyat EMBL from 1991 199910 15 10 45Former EMBL pre or postdocThe unique RNA landscape of the nervous system regulation and functionValerie Hilgers Max Planck Institute of Immunobiology and Epigenetics Germanyat EMBL from 2006 201010 45 11 15Current EMBL group leader Phenotypic variation why your father s microbes matterJamie Hackett EMBL Rome Italy11 15 11 45Coffee Breakkindly sponsored by Zeiss11 45 13 15Session 2 From cells to tissuesChairs Jan Ellenberg11 45 12 15Former EMBL group leader Phase separation and its implications in cell biology and disease Anthony Hyman Max Planck Institute of Molecular Cell Biology and Genetics Germanyat EMBL from 1992 200012 15 12 45Former EMBL pre or postdocPrinciples of tissue dynamics and function captured by imaging live mice the power of multiple lensesValentina Greco Yale University USAat EMBL from 1998 2002Not available on demand12 45 13 15Current EMBL group leader The stem cell zoo to uncover species specific developmental timeMiki Ebisuya Physics of Life TU Dresden Germany EMBL Barcelona SpainNot available on demand13 15 14 45Lunch14 45 16 15Session 3 Developmental biologyChairs Alexander Aulehla Anne Ephrussi14 45 15 15Former EMBL group leader Cell conversions a bit of history and late career workThomas Graf Centre for Genomic Regulation CRG Spainat EMBL from 1983 1998Not available on demand15 15 15 45Former EMBL pre or postdoc Brain evolution reconstructing the origins of the cerebral cortexMaria Tosches Columbia University USA Virtual speaker at EMBL from 2007 201215 45 16 15Current EMBL group leader Cross species biomechanical determinants of shape diversityAissam Ikmi EMBL HeidelbergNot available on demand16 15 16 45Coffee Break kindly sponsored by Zeiss16 45 18 15Session 4 Protein structures and complexesChairs Kristina Djinovic Carugo Matthias Wilmanns16 45 17 15Former EMBL group leader Fifty years of protein structures EMBL Janet Thornton EMBL EBI UKat EMBL from 2001 202317 15 17 45Current EMBL group leader Enabling discovery by in cell structural biologyJulia Mahamid EMBL Heidelberg GermanyNot available on demand17 45 18 15Former EMBL pre or postdoc Transcription of the genomePatrick Cramer President of the Max Planck Society Germanyat EMBL from 1995 199818 15 19 15Pre Dinner Drinks and Networking in the ATC FoyerOption during this time to have photos by the EMBL 50th Photowall with our professional photographers19 15 21 15Dinner in Canteen21 00 22 30 Celebrating EMBL Themed Pub Quiz in canteen Parallel social option 21 15 23 00After dinner drinks in the ATC Foyer and Terrace Parallel social option 21 00Conference shuttle bus From EMBL to all stops downtown including Exzellenz and ISG22 00Conference shuttle bus From EMBL to all stops downtown including Exzellenz and ISG23 00Conference shuttle bus From EMBL to all stops downtown including Exzellenz and ISG Day 2 Friday 5 July 2024 Times Berlin Europe Speakers8 30 9 00Arrival and coffee EMBL conference shuttle bus schedule 09 00 11 00Session 5 Molecules to ecosystemsChairs Peer Bork Nassos Typas09 00 09 30Former EMBL group leader From cell to planetary biologyEric Karsentiat EMBL from 1985 201309 30 10 00Former EMBL pre or postdoc Genomics and AI for One HealthLara Urban Helmholtz Munich Germanyat EMBL from 2015 201910 00 10 30Current EMBL group leader Exploring microbial predator prey interactions in the soilJordi van Gestel EMBL Heidelberg GermanyNot available on demand10 30 11 00Coffee Breakkindly sponsored by Zeiss11 00 12 30Session 6 BioinformaticsChairs Rolf Apweiler Jan Korbel11 00 11 30Former EMBL group leader Digital twins and synthetic data in biomedicineAlfonso Valencia Barcelona Supercomputing Center Spainat EMBL from 1988 199411 30 12 00Former EMBL pre or postdoc Bioimage informatics Fiji and beyondPavel Tomancak Max Planck Institute of Molecular Cell Biology and Genetics Germanyat EMBL from 1995 199912 00 12 30Current EMBL group leader Computational cancer genome analysis at a national scale insights into cancer onset and evolutionIsidro Cortes EMBL EBI UKNot available on demand12 30 14 00Lunch14 00 15 30Session 7 EMBL s technology highlightsChairs Rainer Pepperkok Anna Kreshuk14 00 14 30Former EMBL group leader How human immunodeficiency virus enters the nucleusMartin Beck Max Planck Institute of Biophysics Germanyat EMBL from 2010 202014 30 15 00Former EMBL pre or postdoc Light sheet microscopy past and future of interdisciplinary technology developmentJan Huisken Georg August University G ttingen Germanyat EMBL from 2000 200415 00 15 30Current EMBL group leader X rays for BiologyThomas Schneider EMBL Hamburg GermanyNot available on demand15 30 16 00Coffee Breakkindly sponsored by Zeiss16 00 18 30Session 8 Alumni Celebrating EMBL and its communityChair Pavel Tomancak Chair of the Alumni Association16 00 16 30Address to alumni community Pavel Tomancak16 30 17 00The John Kendrew Award Ceremony Presentation of 2024 John Kendrew Award by Pavel TomancakTalk by 2024 John Kendrew Award recipient Thibaut Brunet17 00 17 30The Lennart Philipson Award CeremonyPresentation of 2024 Lennart Philipson Award by Maria LeptinTalk by 2024 Lennart Philipson Award recipient Giulio Superti Furga17 30 18 30Panel discussion EMBL and Molecular biology The past the present and the futureChairs Edith Heard EMBL Director General Flora Vincent Group Leader EMBL HeidelbergPanelists Ana Boskovic Group Leader EMBL Rome Jan Kosinski Group Leader EMBL Hamburg Paul Nurse Director of The Francis Crick institute Christiane N sslein Volhard Max Planck Institute for Biology T bingen Germany Oliver Stegle EMBL Heidelberg DKFZ Germany18 30 18 45Closing remarks Edith Heard 19 00 21 00Dinner Please take a seat in the canteen or on the terrace outside the canteen after the symposium from 18 45 and help yourself to a drink to start the celebrations To ensure a smooth process without long queues at 19 00 our CCO colleagues will escort you to the buffet in groups Please note In order to join the dinner and party you will need to show your wristband or a conference badge 20 45 21 00Happy 50th Anniversary EMBL cake momentPlease gather by the stage on the terrace21 00 00 00Party on the terrace with live band The Wright Thing and DJ Lucas Ustick22 00Conference shuttle bus From EMBL to all stops downtown including Exzellenz and ISG23 00Conference shuttle bus From EMBL to all stops downtown including Exzellenz and ISG00 00Conference shuttle bus From EMBL to all stops downtown including Exzellenz and ISG Practical information Registration Virtual registration is open to all free of charge and includes access to all of the talks livestreamed and on demand and facility to submit questions On site registration is open to EMBL staff and alumni and is free of charge All staff and alumni will receive an email from the Director General containing a link to register Registration includes admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Registration for the onsite symposium is on a first come first served basis and capacity is limited If you are added to our waiting list please consider taking advantage of the option to participate virtually instead Accredited journalists may be eligible to register for press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact the Events Office for more information Abstract submission There will be no abstract submissions or posters for this conference Accommodation and travel Accommodation is not included in the conference registration As changes to events are possible you are advised to consider booking flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 6 June 2024 in some cases at special rates Please email the hotel directly quoting the booking code LAB24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergHotel Bayrischer Hof Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses The conference shuttle bus timetable can be found here Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop Heidelberg Exzellenz hotel ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen Sie How are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Event platform We are using an event platform for this conference More information about the platform will be sent to you by email just ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page Sponsors Event sponsors Sponsorship opportunitiesWe offer a variety of event sponsorship possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your budget Contact sponsorship embl org for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Rolf Apweiler, Elena Conti, Anne Ephrussi, Eileen Furlong, Cornelius Gross, Rainer Pepperkok, Pavel Tomancak, Nassos Typas

4 July 2024

Ensembl Browser Workshop, Cenicafe

Description The one day browser workshop offers participants the possibility of gaining lots of hands on experience in the use of the Ensembl genome browser but also provides them with the necessary background information The workshop is primarily targeted at wetlab researchers The workshop will consist of a series of modules listed in the content Most modules consist of a presentation and a demonstration of the tools followed by the opportunity to do exercises Participants are encouraged to bring problems questions about their research and we will try to tackle these during the workshop using Ensembl...

Marco Aurelio Cristancho Ardila 

1 July - 5 July 2024

Bioinformatics for immunologists

Description This course will provide participants with an introduction to a range of bioinformatics resources and approaches applicable to immunological research Participants will gain experience in analysis pipelines for NGS experiments relevant to immunology including immune receptor sequencing RNA sequencing single cell RNA sequencing and flow cytometry data analysis Additionally participants will be introduced to how data from several sources can be integrated to provide a wider view of their research thereby enabling them to be more confident users of their own data and that from public sources...

Juanita Riveros

26 June 2024

Data visualisation principles for enhancing effective scientific communication

Description This webinar will provide an introduction to data visualisation principles It includes a review of basic concepts and showcases tools to improve your understanding and use of data visualisation for improved accessibility to your research As we know collecting data is just the first step to advancing scientific knowledge Data presentation techniques are the key to communicating your findings in a concise manner to improve understanding across audiences and ultimately strengthening your contributions to your field The webinar speaker Isabel Romero Calvo PhD MS Scientific Illustrator will present information that will help you gain insights into Gestalt principlesConcept of salience and graphic perceptionUse of colour in data visualisationAccessibility in data visualisationWe will conclude with a Q A session for the webinar attendees...

24 June - 28 June 2024

Cancer genomics and transcriptomics

Description This course will focus on the analysis of data from genomic studies of cancer It will also highlight the application of transcriptomic analysis and single cell technologies in cancer Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 08 45 17 00 BST each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Meredith Willmott

18 June - 21 June 2024

Innate immunity in host-pathogen interactions

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview This follow up meeting to the successful EMBO EMBL Symposia Innate immunity in Host Pathogen Interactions in 2016 2018 and 2022 will provide a discussion and networking platform for all scientists interested in the biology of pathogen infection The symposium will promote the exchange of conceptual ideas in this rapidly evolving field and also foster cross disciplinary collaborations among the scientists Innate immunity is studied by both microbiologists and immunologists however their perspectives differ widely Microbiologists are necessarily specialists for their pathogen s of choice while immunologists tend to focus on the host response The goal of the conference is to bring together immunologists microbiologists and cell biologists who from their specific points of view will discuss recent progress in their understanding of host pathogen interactions The conference will have a balanced representation of viruses bacteria fungi and for the first time parasites as the major classes of medically relevant animal or economically important plant pathogens A unique aspect of the meeting will be the holistic approach of discussing host pathogen interactions also across phylogenetically distant hosts i e plants and animals Session topics Sensing pathogens The cell biology of infection Signaling upon pathogen detection Cell autonomous immunity Pathogen countermeasures Pathological consequences of infection and inflammation What past participants say about the Symposium This conference is exceptionally good and was my first conference at EMBL Various topics of innate immune response has been covered in this conference which further broaden my knowledge in the field of host pathogen interaction s Very well organised and good networking opportunity for the people in the field of immunology and microbiology Sanpreet Singh CSIR IMTech India As my first international symposium the EMBO EMBL Symposium Innate Immunity in Host Pathogen Interactions was inspiring great fun and facilitated both scientific exchange and networking It was great to present my PhD work to a very engaged audience featuring many major names in my field Looking forward to next time Conor O Donovan MRC LMB Cambridge UK This conference is the best of its kind in bringing together researchers who work in hostpathogen interactions The format was great and the conference was exceptionally wellorganized Cynthia Guo University of Toronto Canada Speakers Keynote speakers Vishva Dixit Genentech USA Dominique Soldati Favre University of Geneva Switzerland Speakers Aude Bernheim Institut Pasteur France Jelena Bezbradica Mirkovic Kennedy Institute of Rheumatology UK Gordon Brown University of Exeter UK Ken Cadwell University of Pennsylvania USA Rachael Dangarembizi University of Cape Town South Africa Della David Babraham Institute UK Trude Helen Flo Norwegian University of Science and Technology Norway Michaela Gack Cleveland Clinic Foundation USA Veit Hornung Ludwig Maximilians Universit t M nchen Germany Bernhard Hube Leibniz Institute for Natural Product Research and Infection Biology Hans Kn ll Institute Germany Jonathan Jones The Sainsbury Laboratory UK Marc Lecuit Institut Pasteur France Jonathan Pruneda Oregon Health Science University USA John Schoggins The University of Texas Southwestern Medical Center USA Wai Hong Tham Walter and Eliza Hall Institute of Medical Research Australia Julia Vorholt ETH Z rich Switzerland Sho Yamasaki Research Institute for Microbial Diseases Japan Jian Min Zhou Yazhouwan National Laboratory China Scientific organisers Gordon Brown University of Exeter UK Michaela Gack Cleveland Clinic Foundation USA Felix Randow MRC Laboratory of Molecular Biology UK Dominique Soldati Favre University of Geneva Switzerland Cyril Zipfel University of Z rich Switzerland Conference organisers Iva Gavran EMBL Heidelberg Germany Programme Are you on social media Post using EESImmunity and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 18 June 2024 Time Europe Berlin Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 14 45Keynote talk Toxplasma gondii a persisting challengeDominique Soldati Favre University of Geneva Switzerland14 45 18 15Session 1 Sensing pathogensTrude Flo Norwegian University of Science and Technology Norway14 45 15 15Immune responses to mycobacterial lipidsSho Yamasaki Research Institute for Microbial Diseases JapanNot available on demand15 15 15 30Recognition of phylogenetically diverse pathogens through enzymatically amplified recruitment of RNF213Ana Crespillo Casado MRC Laboratory of Molecular Biology UK15 30 15 45Immune recognition of structured phage RNA by bacterial cGASDalton Banh Rockefeller University USA15 45 16 15Coffee Break and Meet the speakers with Dominique Soldati Favre and Sho Yamasaki16 15 16 45Understanding and exploiting plant immune receptor mechanismsJonathan Jones The Sainsbury Laboratory UK16 45 17 00ADAR1 haploinsufficiency and viral RdRp dsRNA synthesis synergize to dysregulate RNA editing and cause multi system interferonopathyEric Poeschla University of Colorado School of Medicine USA 17 00 17 15The epigenetic reader SP140 participates in a host virus nuclear arms race by regulating inteferon beta mRNA stability via RESISTRussel Vance HHMI University of California Berkeley USA17 15 18 15Speed networking session18 15 19 45BBQ dinner19 45 21 30After dinner drinks in ATC Rooftop lounge Day 2 Wednesday 19 June 2024 Time Europe Berlin Speaker09 00 12 00Session 2 The cell biology of infectionChair Cyril Zipfel University of Z rich Switzerland09 00 09 30M tuberculosis induced cell death and a new macrophage alveolar epithelial cell co culture modelTrude Flo Norwegian University of Science and Technology NorwayNot available on demand09 30 09 45The macrophage endoplasmic reticulum protein VAPA participates in the salvage of host lipids by Leishmania amazonensisAlbert Descoteaux Institut national de la recherche scientifique Canada09 45 10 00Nucleotide Based Defense Strategies in Bacterial Antiviral ImmunityNitzan Tal Weizmann Institute of Science Israel10 00 10 30Coffee Break and Meet the speakers with Jonathan Jones and Trude Flo10 30 11 00Nanobodies that block malaria parasite transmissionWai Hong Tham Walter and Eliza Hall Institute of Medical Research Australia11 00 11 15The role of fungal cell wall in predation by immune cells and bacteriaAgate Auzane University of Exeter UK11 15 11 45A functional screen for ubiquitin regulation identifies an E3 ligase secreted by Pseudomonas aeruginosaJonathan Pruneda Oregon Health Science University USA11 45 12 00Keep an eye on both sides Host membrane microdomains are required for Mycobacterium marinum induced membrane damage and infectionThierry Soldati University of Geneva Switzerland12 00 13 30Lunch and Meet the Editors 30min at the end of lunch 13 30 16 30Session 3 Signaling upon pathogen detectionChair Chair Michaela Gack Cleveland Clinic Foundation USA13 30 14 00Harnessing C elegans pathogen response to mitigate protein aggregationDella David Babraham Institute UK14 00 14 15A host AAA ATPase employs chemo mechanical force to exhibit bacteriolytic activitySourav Ghosh Indian Institute of Technology Bombay India14 15 14 30Deciphering oligomerization effects on plant receptor activity in innate immunityZhiming Ma Nanyang Technological University Singapore14 30 14 45 Discovery of a novel actor of the TLR4 pathway using comparative immunology across domains of lifeHugo Vaysset Institut Pasteur FranceNot available on demand14 45 15 15Coffee Break and Meet the speakers with Wai Hong Tam Jonathan Pruneda and Della David15 15 15 45CLRs Autoimmunity and immunity to fungal infection a new link Gordon Brown University of Exeter UK15 45 16 00Identification and characterization of plant cytokinesJack Rhodes The Sainsbury Laboratory UK16 00 16 30Intersection of plant immunity and microbiota homeostasisJulia Vorholt ETH Z rich Switzerland16 30 17 15Flash talks 55 57 61 63 77 83 85 87 115 131 133 137 15717 15 19 15Poster Session 1 odd numbers with beer and snacks19 15Free evening Day 3 Thursday 20 June 2024 Time Europe Berlin Speaker09 00 12 00Session 4 Cell autonomous immunityChair Felix Randow MRC Laboratory of Molecular Biology UK09 00 09 30TRIMming autophagic antiviral host defensesMichaela Gack Cleveland Clinic Foundation USANot available on demand09 30 09 45Metabolic enzymes moonlight as selective autophagy receptors to protect plants against viral induced cellular damageMarion Clavel Max Planck Institute of Molecular Plant Physiology Germany09 45 10 00How cytosolic bacteria inhibit RNF213 mediated cell autonomous immunityMagdalena Szczesna Imperial College London UK10 00 10 30Coffee Break and Meet the speakers with Gordon Brown Julia Vorholt and Michaela Gack10 30 11 00Membrane channels as facilitators of immune cell cross talk in infection and inflammationJelena Bezbradica Mirkovic Kennedy Institute of Rheumatology UK11 00 11 15Metabolism infection and inflammation the immunometabolic interplay of salmonella persistence in macrophagesMatthew Eldridge Harvard Medical School USA11 15 11 45Evolution of anti viral immunity across domains of lifeAude Bernheim Institut Pasteur France11 45 12 00Evolution guided enhancement of MxA antiviral properties against influenza virusRechel Geiger Fred Hutch Cancer Center USA12 00 13 30Lunch 13 30 16 30Session 5 Pathogen countermeasuresChair Dominique Soldati Favre University of Geneva Switzerland13 30 14 00New models of interferon mediated antiviral immunityJohn Schoggins The University of Texas Southwestern Medical Center USA14 00 14 15Targeted degradation of host messenger RNA by a bacterial effector modulates macrophage metabolismKitty McCaffrey Hudson Institute of Medical Research AustraliaNot available on demand14 15 14 30The bacterial effector SteD reduces surface levels of MHCII by activating the E3 ubiquitin ligase WWP2Samkeliso Blundell Imperial College London UK14 30 15 00Coffee Break and Meet the speakers with Jelena Bezbradica Mirkovic Aude Bernheim and John Schoggins15 00 15 30The commensal training ground of Candida albicansBernhard Hube Leibniz Institute for Natural Product Research and Infection Biology Hans Kn ll Institute Germany15 30 15 45Direct antimicrobial functions of HMGB1 and countermeasures deployed by Gram negative bacteriaJeannette Messer Cleveland Clinic USA15 45 16 15Understanding immune signaling and chemical defense against phytopathogenic bacteriaJian Min Zhou Yazhouwan National Laboratory ChinaNot available on demand16 15 16 30Activation and Evasion of the FACT ETS 1 Antiviral Response Pathway by RNA VirusesEmily Rex University of Texas Southwestern Medical Center USA16 30 16 45Flash talks 52 56 84 8616 45 18 45Poster Session 2 even numbers with beer and snacks18 45 20 30Dinner in the canteen20 30 23 30Conference party with live music Day 4 Friday 21 June 2024 Time Europe Berlin Speaker09 30 13 45Session 6 Pathological consequences of infection and inflammationChair Gordon Brown University of Exeter UK09 30 10 00How Listeria outsmarts the hostMarc Lecuit Institut Pasteur FranceNot available on demand10 00 10 15The contribution of the innate immune response to blood brain barrier breakdown in Cerebral MalariaAlina Batzilla EMBL Barcelona Spain10 15 10 45The counterintuitive innate neuroimmune response to cryptococcal infectionRachael Dangarembizi University of Cape Town South Africa10 45 11 15Coffee Break and Meet the speakers with Bernhard Hube Jian Min Zhou Marc Lecuit Rachael Dangarembizi Ken Cadwell Veit Hornung and Vishva Dixit11 15 11 45Autophagy at the host microbe interfaceKen Cadwell University of Pennsylvania USA11 45 12 00Brain endothelial GSDMD activation mediates inflammatory BBB breakdownWei Jiang National Institute of Biological Sciences China12 00 12 30Detection of non self nucleic acids in the endolysosomeVeit Hornung Ludwig Maximilians Universit t M nchen GermanyNot available on demand12 30 13 30Why so many ways to die Vishva Dixit Genentech USA13 30 13 45Closing Remarks and Poster Prize Announcements13 45 14 15Packed Lunch and departure14 15Bus to airport tickets available at registration desk 14 30Conference shuttle Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Iva Gavran for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 21 May 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 08 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Conference shuttle bus schedule Shuttle bus stops please see Google map with the stops below The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions and travelling to EMBL on our Information for participants page Sponsors Event sponsor ABclonal Germany Disease Models Mechanisms The Company of Biologists InvivoGen MedChemExpress Event supporters Media partners EMBO Reports an EMBO Press journal FEBS Journal FEBS Letters International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Gordon Brown, Michaela Gack, Felix Randow, Dominique Soldati-Favre, Cyril Zipfel

17 June - 21 June 2024

Summer school in bioinformatics

Description This course provides an introduction to the use of bioinformatics in biological research giving you guidance for using bioinformatics in your work whilst also providing hands on training in tools and resources appropriate to your research You will initially be introduced to bioinformatics theory and practice including best practices for undertaking bioinformatics analysis data management and reproducibility You will be required to review some pre recorded material for their group project prior to the start of the course Group projectsA major element of this course is a group project where you ll be placed in small groups to work together on a challenge set by trainers from EMBL EBI and external institutes This allows you to explore the bioinformatics tools and resources available in your area of interest and apply them to a set problem providing you with hands on experience relevant to your own research The group work will culminate in a presentation session involving everyone on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of working with biological data Groups are mentored and supported by the trainers who set the initial challenge but the groups will be responsible for driving their projects forward with all members expected to take an active role Groups are pre organised before the course and all group members will be sent some short homework in preparation for your project work prior to the start of the course Basic outlines of the projects on offer this year are given below In your application you must indicate your first and second choice of project based on which you think would benefit your research most Not all projects may be offered and final decisions on which projects will be run during the course will be made based on the number of applicants per project Most of the projects cover mammalian data sets however in many cases the methods and approaches taught are transferable to data from various species Group project one Genome variation across human populations Natural variation between individuals or between different human populations is a result of genome mutations throughout evolutionary history Some mutations may become fixed because of their beneficial effect while most drift among individuals During this project you will investigate genomic variation between two separate human populations of European and Asian descent Using sequence data from a number of individuals from each population you will use a range of bioinformatics tools to discover variants that exist between them In the second section of the project you will attempt to analyse the functional consequences of the variants you have identified attempting to find clinical association and linking them to phenotypes Project mentor Anu Shivalikanjli EMBL EBI Group project two Interpreting functional information from large scale protein structure dataThis project will introduce you to the wealth of publicly available data in the Protein Data Bank PDB and give you the opportunity to investigate how large subsets of structure data can be used to analyse protein features and determine function In the project you will learn how to identify relevant protein structures collate and interpret functional information and implement this process programmatically Project mentor Marcus Bage EMBL EBI and Joseph Ellaway EMBL EBIGroup project three Modelling cell signalling pathwaysCurating models of biological processes is an effective training in computational systems biology where the curators gain an integrative knowledge of biological systems modelling and bioinformatics You will learn to encode and simulate ordinary differential equation models of signalling pathways from a recent publication using user friendly software such as COPASI even without extensive mathematical background You will learn to perform in silico experiments new predictions and develop hypotheses Furthermore you will learn how to annotate models and re use pre existing models from open repositories such as BioModels Project mentors Rahuman Sheriff EMBL EBI and Krishna Tiwari EMBL EBI Group project four Improving AI based bioimage analysis Artificial Intelligence AI algorithms outperform classical image analysis methods however the performance of these models is highly dependent on the quality of the annotated image datasets used to train them In this project you will explore the application of AI for biological imaging and the relationship between model training data and model performance You will use models stored in the BioImage Model Zoo and data in the BioImage Archive to fine tune and aggregate AI outputs The aim of this project will be to test evaluate and improve model performance on a diverse set of microscopy images and annotations within the BioImage Archive You will learn how to apply train tune and employ the most performant state of the art computer vision models This project serves as a valuable demonstration of how FAIR Findable Accessible Interoperable Reusable data plays an essential role in the training and enhancement of AI models Project mentors Aybuke Kupcu Yoldas EMBL EBI and Craig Russel EMBL EBI Group project five Single cell RNA sequencing analysis with PythonIn this project you will learn how to perform single cell RNA sequencing data analysis to investigate cell type heterogeneity and expression differences across conditions The analysis will be based on the SCANPY framework in Python You will start by collecting the raw count matrix and relevant metadata from the Single cell Expression Atlas After constructing the AnnData objects you will perform quality control preprocessing dimensionality reduction cell type annotation and differential expression analysis We will also explore the batch effect and its correction Project mentors Yuyao Song EMBL EBI and Anna Vathrakokoili Pournara EMBL EBI Group project six Networks and pathwaysThis project will cover typical bioinformatics analysis steps needed to put differentially expressed genes into a wider biological context You will start with gene expression data RNA seq to build an initial interaction network Next you will learn to combine public network datasets identify key regulators of biological pathways and explore biological function through network analysis You will get first hand experience in integration and co visualising with additional data and functional enrichment analysis All this helps to put the initial results into a previously known context and provide hypotheses for potential follow up experiments We will use Cytoscape Expression Atlas g Profiler StringDb among other tools We may also give a few R packages a try Project mentor Priit Adler University of Tartu...

Barbara Etzi

10 June - 14 June 2024

Systems biology: from large datasets to biological insight

Description This course covers the use of computational tools to extract biological insight from omics datasets The content will explore a range of approaches ranging from network inference and data integration to machine learning and logic modelling that can be used to extract biological insights from varied data types Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large scale biological data The motivation for running this course is a result of advances in computer science and high performance computing that have led to groundbreaking developments in systems biology model inference With the comparable increase of publicly available large scale biological data the challenge now lies in interpreting them in a biologically valuable manner Likewise machine learning approaches are making a significant impact in our analysis of large omics datasets and the extraction of useful biological knowledge...

Juanita Riveros

9 June - 15 June 2024

C. elegans: from genome editing to imaging

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview C elegans is a popular experimental model that combines transparency reproducible anatomy traceable cell lineage sequenced genome and facile genetics allowing to dissect animal development physiology and behaviour across scales of genes cells and tissues This 7 day course will present experimental practices in C elegans research while introducing historic and up to date findings in various research topics Each day includes lectures practicals student poster presentations and interactive discussions with faculty Various methodologies commonly employed in C elegans research will be presented in parallel practicals with rotating student groups by relevant experts These experimental techniques span forward and reverse genetics genome editing lineaging imaging approaches for live and fixed samples using light and electron microscopy computational image analysis and other useful web resources Meanwhile lectures by internationally established researchers will present a variety of C elegans research topics spanning studies of the genome and epigenome through cell cycle and death to tissue specification connectivity and function A combination of senior and junior speakers will ensure a balanced view of pioneer breakthroughs and recent advances in the topics presented as well as the students interactions with researchers of different topics and career levels Audience This practical course will be aimed at early career scientists mostly postdocs and advanced graduate students with an interest in C elegans We will target both participants with little or no prior experience in working with C elegans who want to use this model organism to advance their research as well as experienced C elegans researchers who want to expand their tool set The course will cover state of the art techniques that are or will become essential for a broad range of research topics and we will therefore target participants with diverse research interests Modules resources The course lectures and practical modules develop in three axes of genes cells tissues It will cover the following modules Lectures Genome and epigenome structure function silencing environment interactions Cell cycle division symmetry breaking cell biomechanics Cell death and degeneration in development aging and genome instability in disease Tissue specification transcriptome dynamics morphogenesis Tissue morphogenesis cell lineage tracing and forces Tissue assembly connectivity activity cell interactions Practicals Web resources for C elegans research C elegans handling and genetic manipulations Imaging fixed live cells and molecules Image analysis deconvolution EM image analysis optogenetics tracing and lineaging approaches Learning outcomes After this course you should know The advantages of C elegans for your research Handling and maintenance of C elegans Staging and C elegans life cycle Designing and performing forward and reverse genetics experiments Principles of generating transgenic animals The potential of C elegans imaging from live imaging to high resolution imaging EM and optogenetics Options for analysis of light and EM images optogenetics cell tracing What past participants say about the course The c elegans from genome editing to imaging is one of the best C elegans practical courses and I would strongly recommend C elegans researchers in their early careers to attend this course Somarani Dash Institute of advanced study in science and technology Guwahati Assam India This course far exceeded my expectations it was the perfect mixture of theory hands onexperiments and networking An incredible opportunity not only to learn but also to meet peoplefrom all over the world Antonella Lavatellai Centre for Research in Agricultural Genomics Barcelona Spain The course has a recommendation rate of 100 from previous attendees Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course This event has been granted the following EMBO sustainability badge Grade 2 of 3 Speakers Speakers trainers and staff Michalis Barkoulas Imperial College UK Virtual Speaker Simon Berger University of Zurich Switzerland Virtual Speaker Mandy Boermel EMBL Heidelberg Germany Ed Boyden MIT McGovern Institute USA Virtual Speaker Henrik Bringmann Biotechnology Center Germany Inka Busack Biotechnology Center Germany Francesca Caroti EMBL Heidelberg Germany Dhanya K Cheerambathur The University of Edinburgh UK Monica Driscoll Rutgers University USA Virtual Speaker Marie Anne Felix Institut Biologie Ecole Normale Superieure France Christian Fr kj r Jensen King Abdullah University Saudi Arabia Susan Gasser University of Lausanne and ISREC Foundation Switzerland Guoye Guan Peking University China Virtual Trainer Alex Hajnal University of Zurich Switzerland Virtual Speaker Oliver Hobert Columbia University USA Virtual Speaker Simone K hler EMBL Heidelberg Germany Marko Lampe EMBL Heidelberg Germany Zelin Li University of Hong Kong Hong Kong Virtual trainer Yangning Lu MIT McGovern Institute USA Rachel Mellwig EMBL Heidelberg Germany Ben Mulcahy Lunenfeld Tanenbaum Research Institute Canada Virtual trainer Alexandre Paix Max Planck Institute for Biology T bingen Germany Cristina Pineiro Lopez EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Suzan Ruijtenberg Utrecht University The Netherlands Piali Sengupta Brandeis University USA Virtual Speaker Pavak Shah University of California Los Angeles USA Priya Sivaramakrishnan Children s Hospital of Philadelphia USA Virtual trainer Johanna Tocci EMBL Heidelberg Germany Zhongying Zhao Hong Kong Baptist University Hong Kong Scientific organisers Henrik Bringmann Biotechnology Center Germany Simone K hler EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Pavak Shah University of California Los Angeles USA Event organisers Maria Bacadare Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Are you on social media Post using EMBOCelegans and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Onboarding Monday 27 May 2024 Time Europe Berlin SpeakerLocation15 30 17 00Onboarding session access to eCampus learning platform introduction on Zoom introduction to the course materials to be used and expectations from the participants overview of the tools used during the courseEMBL eCampus Day 1 Sunday 9 June 2024 Time Europe Berlin SpeakerLocation09 45 10 00Bus from hotel to EMBL ATC EntranceISG Hotel bus stop10 00 10 30Health and safety briefingCourtyard Room A B10 30 13 30Optional Bootcamp A or BOption A Basic C elegans methodology maintenance propagation decontaminationTrainers Simone K hler EMBL Heidelberg GermanyGeorgia Rapti EMBL Heidelberg GermanyCristina Pi eiro L pez EMBL Heidelberg GermanyFrancesca Caroti EMBL Heidelberg GermanyOption B Basic principles for image analysisTrainer Pavak Shah University of California Los Angeles USATraining LabComputer Training LabCourtyard Room13 30 14 30Lunch EMBL Canteen14 30 14 45Bus from EMBL ATC Entrance to hotel ATC Entrance15 00 15 30ISG Hotel registrationISG Hotel15 30 15 45WelcomeSimone K hler EMBL Heidelberg GermanyGeorgia Rapti EMBL Heidelberg GermanyISG Hotel15 45 16 15Flash talks 1 min per participant ISG Hotel16 15 17 15Challenges expectations for the course all participants ISG Hotel17 15 17 30Coffee breakISG Hotel17 30 17 45Course overviewSimone K hler EMBL Heidelberg GermanyGeorgia Rapti EMBL Heidelberg GermanyISG Hotel17 45 18 45Introduction to useful web resources and databases for C elegans researchIntroduction on responsible conduct of researchSimone K hler EMBL Heidelberg GermanyGeorgia Rapti EMBL Heidelberg GermanyISG Hotel18 45 19 00BreakISG Hotel19 00 20 00DinnerISG Hotel Day 2 Monday 10 June 2024 Time Europe Berlin SpeakerLocation08 40 08 50Bus to EMBL ATC EntranceISG Hotel bus stop08 55 09 00Overview of the dayCourtyard Room A B09 00 09 30Lecture Imaging the worm nucleus through developmentSusan Gasser University of Lausanne and ISREC Foundation SwitzerlandCourtyard Room A B09 30 09 45Q A after the lectureCourtyard Room A B09 45 10 15Lecture Genome engineeringChristian Fr kj r Jensen King Abdullah University Saudi ArabiaCourtyard Room A B10 15 10 30Q A after the lectureCourtyard Room A B10 30 11 00Coffee breakCourtyard Room A B11 00 11 30Lecture Optogenetic manipulation of tissue activityHenrik Bringmann Biotechnology Center GermanyCourtyard Room A B11 30 11 45Q A after the lectureCourtyard Room A B11 45 12 15Health and safety briefingCourtyard Room A B12 15 13 15Lunch breakEMBL Canteen13 15 19 30Practical Methods of genome manipulation Part 1Station 1 Screening RNAi mutagenesis Trainer Francesca Caroti EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Station 2 Transgenesis sample preparation injection Trainer Simone K hler EMBL Heidelberg Germany Cristina Pi eiro L pez EMBL Heidelberg Germany Station 3 Design for CRISPRs MoSCIs arrays Trainer Christian Fr kj r Jensen King Abdullah University Saudi Arabia Alexandre Paix Max Planck Institute for Biology T bingen Germany Station 4 In silico Lineaging Transcriptomics design analysisTrainer Priya Sivaramakrishnan University of Pennsylvania USAStation 1 Training Lab BStation 2 Simone s LabStation 3 Courtyard RoomStation 4 Flex labs19 30 20 30Dinner with guided discussion on Publishing and Grant writing EMBL Canteen20 30Bus to ISG HotelATC Entrance Day 3 Tuesday 11 June 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus to EMBL ATC EntranceISG Hotel bus stop08 55 09 00Overview of the dayCourtyard Room A B09 00 10 45Practical Methods of genome manipulation Part 1Station 1 Screening RNAi mutagenesis Trainer Francesca Caroti EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Station 2 Transgenesis sample preparation injection Trainer Simone K hler EMBL Heidelberg Germany Cristina Pi eiro L pez EMBL Heidelberg Germany Station 3 Design for CRISPRs MoSCIs arrays Trainer Christian Fr kj r Jensen King Abdullah University Saudi Arabia Alexandre Paix Max Planck Institute for Biology T bingen Germany Station 4 In silico Lineaging Transcriptomics design analysisTrainer Priya Sivaramakrishnan University of Pennsylvania USAStation 1 Training Lab BStation 2 Simone s LabStation 3 Courtyard RoomStation 4 Flex labs10 45 11 30Coffee breakCourtyard Room A B11 30 12 00Lecture Cell fate and the cell cycle of the early embryoPavak Shah University of California Los Angeles USACourtyard Room A B12 00 12 15Q A after the lectureCourtyard Room A B12 15 12 45Lecture Expansion microscopy of C elegansEd Boyden MIT McGovern Institute USA Virtual Speaker 12 45 13 00Q A after the lecture13 00 14 00Lunch break with guided discussion on Choosing a postdoc Getting a research PI position EMBL Canteen14 00 17 00Practical Imaging cells and molecules Part 1Station 1 Live imaging and Lineaging Trainer Francesca Caroti EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Pavak Shah University of California Los Angeles USA Station 2 Expansion Microscopy Trainer Yangning Lu MIT McGovern Institute USA Simone K hler EMBL Heidelberg Germany Cristina Pi eiro L pez EMBL Heidelberg Germany Station 3 Basics in Optogenetics Trainer Inka Busack Biotechnology Center GermanyStation 4 Electron Microscopy Trainer Mandy Boermel EMBL Heidelberg Germany Rachel Mellwig EMBL Heidelberg Germany Station 1 Microscopy room 116 ALMFStation 2 Training Lab BStation 3 ALMFStation 4 EM facility17 00 17 30Coffee breakCourtyard Room A B17 30 18 00Lecture Cytoskeletal assembly and dynamics in neurodevelopmentDhanya Cheerambathur The University of Edinburgh UKCourtyard Room A B18 00 18 15Q A after the lectureCourtyard Room A B18 15 18 30Coffee breakCourtyard Room A B18 30 19 30Poster session Helix A19 30 21 00Dinner with poster networking All posters Helix A21 00Bus to ISG HotelATC Entrance Day 4 Wednesday 12 June 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus to EMBL ATC EntranceISG Hotel bus stop08 55 09 00Overview of the dayCourtyard Room A B09 00 09 30Lecture Imaging and understanding translation regulation in development Suzan Ruijtenberg Utrecht University The NetherlandsCourtyard Room A B09 30 09 45Q A after the lectureCourtyard Room A B09 45 10 00Coffee breakCourtyard Room A B10 00 10 30Lecture Genotype to phenotype relationshipMichalis Barkoulas Imperial College UK Virtual Speaker Courtyard Room A B10 30 10 45Q A after the lectureCourtyard Room A B10 45 11 15Lecture Molecular Promotion of Healthy Aging Monica Driscoll Rutgers University USA Virtual Speaker Courtyard Room A B11 15 11 30Q A after the lectureCourtyard Room A B11 30 11 45Group photoCourtyard Room A B11 45 12 30Lunch break with guided discussion on Science policy communication Choosing a postdoc EMBL Canteen12 30 19 00Practical Imaging cells and molecules Part 2 Station 1 Live imaging and Lineaging Trainer Francesca Caroti EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg GermanyPavak Shah University of California Los Angeles USA Station 2 Expansion Microscopy Trainer Yangning Lu MIT McGovern Institute USA Simone K hler EMBL Heidelberg Germany Cristina Pi eiro L pez EMBL Heidelberg Germany Station 3 Basics in Optogenetics Trainer Inka Busack Biotechnology Center Germany Station 4 Electron Microscopy Trainer Mandy Boermel EMBL Heidelberg Germany Rachel Mellwig EMBL Heidelberg Germany Paolo Ronchi EMBL Heidelberg GermanyStation 1 Microscopy room 116 ALMFStation 2 Training Lab BStation 3 ALMFStation 4 EM facility19 00 20 00DinnerEMBL Canteen20 00Bus to ISG HotelATC Entrance Day 5 Thursday 13 June 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus to EMBL ATC EntranceISG Hotel bus stop08 55 09 00Overview of the dayCourtyard Room A B09 00 12 00Practical Imaging cells and molecules Part 3 Station 1 Live imaging and Lineaging Trainer Francesca Caroti EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Pavak Shah University of California Los Angeles USA Station 2 Expansion Microscopy Trainer Yangning Lu MIT McGovern Institute USASimone K hler EMBL Heidelberg Germany Cristina Pi eiro L pez EMBL Heidelberg Germany Station 3 Basics in Optogenetics Trainer Inka Busack Biotechnology Center GermanyStation 4 Electron Microscopy Trainer Mandy Boermel EMBL Heidelberg Germany Rachel Mellwig EMBL Heidelberg Germany Paolo Ronchi EMBL Heidelberg GermanyStation 1 Microscopy room 116 ALMFStation 2 Training Lab BStation 3 ALMFStation 4 EM facility12 00 13 00Lunch break with guided discussion on Starting a junior PI position Positions in PUI institutions EMBL Canteen13 00 16 00Practical Advanced image analysis tools Station 1 Deconvolution Trainer Marko Lampe EMBL Heidelberg Germany Station 2 Automated membrane tracingTrainer Zhongying Zhao Li Zelin Virtual trainer Guoye Guan Virtual Trainer Station 3 Lineage tracing analysis Trainer Pavak Shah University of California Los Angeles USA Station 4 Image analysis for optogenetics Trainer Inka Busack Biotechnology Center Germany Station 5 Analysis of EM imaging Trainer Ben Mulcahy Lunenfeld Tanenbaum Research Institute CanadaStation 1 Computer Training LabStation 2 Flex Lab A Station 3 Courtyard room Station Station 4 B18 Station Station 5 Flex Lab B16 00 16 30Coffee breakCourtyard Room A B16 30 17 00Lecture Automated high throughput imaging of C elegans Applications and future possibilitiesAlex Hajnal University of Zurich Switzerland Virtual speaker Simon Berger University of Zurich Switzerland Virtual speaker Courtyard Room A B17 00 17 15Meet the speaker Alex Hajnal University of Zurich Switzerland Virtual Speaker Simon Berger University of Zurich Switzerland Virtual speaker Courtyard Room A B17 15 17 45Lecture Neurogenetics of sensory behaviorsPiali Sengupta Brandeis University USA Virtual Speaker Courtyard Room A B17 45 18 00Meet the speaker Piali Sengupta Brandeis University USA Virtual Speaker Courtyard Room A B18 00 18 30Coffee breakCourtyard Room A B18 30 19 00Lecture Self organization in meiosisSimone K hler EMBL Heidelberg GermanyCourtyard Room A B19 00 19 15Meet the speaker Simone K hler EMBL Heidelberg GermanyCourtyard Room A B19 15 20 45Dinner with poster networking All posters Helix A20 45Bus to ISG HotelATC Entrance Day 6 Friday 14 June 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus to EMBL ATC EntranceISG Hotel bus stop08 55 09 00Overview of the dayCourtyard Room A B09 00 12 00Practical Advanced image analysis tools Station 1 Deconvolution Trainer Marko Lampe EMBL Heidelberg Germany Station 2 Automated membrane tracingTrainers Zhongying Zhao Hong Kong Baptist University Hong KongGuoye Guan Peking University China Virtual trainer Li Zelin University of Hong Kong Hong Kong Virtual trainer Station 3 Lineage tracing analysis Trainer Pavak Shah University of California Los Angeles USA Station 4 Image analysis for optogenetics Trainer Inka Busack Biotechnology Center Germany Station 5 Analysis of EM imaging Trainer Ben Mulcahy Lunenfeld Tanenbaum Research Institute CanadaStation 1 Computer Training Lab Station 2 Flex Lab A Station 3 Courtyard room Station 4 B18 Station 5 Flex Lab B12 00 13 00LunchEMBL Canteen13 00 13 30Lecture Generation of neuronal diversityOliver Hobert Columbia University USA Virtual Speaker Courtyard Room A B13 30 13 45Meet the speaker Oliver Hobert Columbia University USACourtyard Room A B13 45 14 00Coffee breakCourtyard Room A B14 00 16 30Practical Advanced image analysis tools Station 1 Deconvolution Trainer Marko Lampe EMBL Heidelberg Germany Station 2 Automated membrane tracingTrainers Zhongying Zhao Hong Kong Baptist University Hong KongGuoye Guan Peking University China Virtual trainer Li Zelin University of Hong Kong Hong Kong Virtual trainer Station 3 Lineage tracing analysis Trainer Pavak Shah University of California Los Angeles USA Station 4 Image analysis for optogenetics Trainer Inka Busack Biotechnology Center Germany Station 5 Analysis of EM imaging Trainer Ben Mulcahy Lunenfeld Tanenbaum Research Institute CanadaStation 1 Computer Training Lab Station 2 Flex Lab A Station 3 Courtyard room Station 4 B18 Station 5 Flex Lab B16 30 17 00Bus to downtownATC Entrance17 00 19 00Free time19 00Dinner downtown Day 7 Saturday 15 June 2024 Time Europe Berlin SpeakerLocation09 40 09 55Bus to EMBL ATC EntranceISG Hotel bus stop09 55 10 00Overview of the dayCourtyard Room A B10 00 10 30Lecture Evolution of C elegansMarie Anne F lix Institut Biologie Ecole Normale Superieure FranceCourtyard Room A B10 30 10 45Meet the speaker Marie Anne F lix Institut Biologie Ecole Normale Superieure FranceCourtyard Room A B10 45 11 15Coffee breakCourtyard Room A B11 15 11 45Lecture Glia neuron interactions in nervous system assemblyGeorgia Rapti EMBL Heidelberg GermanyCourtyard Room A B11 45 12 00Meet the speaker Georgia Rapti EMBL Heidelberg GermanyCourtyard Room A B12 00 12 30Feedback session and closing remarksCourtyard Room A B12 30Bus from EMBL to Heidelberg city center train station or Walk to ISGATC Entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation in single rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 8 to 15 7 nights This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partner Event sponsors Event supporters Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1600 900 PPT Slide 16 x9...

Henrik Bringmann, Simone Koehler, Georgia Rapti, Pavak Shah

7 June 2024

AlphaMissense predictions for human genetic variation research

Description This webinar will explore AlphaMissense a model based on AlphaFold AlphaMissense is designed to analyse missense variants which are individual amino acid changes in proteins Classifying these variants is crucial for understanding which ones might contribute to disease development Our guest speaker from Google DeepMind will introduce AlphaMissense You will gain insights into its underlying technology how it analyses variants and what the generated scores represent Importantly all predictions from AlphaMissense are freely available to the scientific community The webinar will then showcase how EMBL EBI resources integrate AlphaMissense data This includes details on how the data is stored displayed and accessed by researchers studying human genetic variations We will conclude by a question and answer session with all the presenters...

5 June - 8 June 2024

Microtubules: from atoms to complex systems

Description OverviewSpeakersProgrammePractical infomationAboutSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Transport alert storm damage is affecting some rail routes in southern Germany Please check your journey on the website of the German rail operator Deutsche Bahn if travelling by train Symposium overview This symposium initiated in 2010 has taken place every second year since and brings together early career and established researchers from all over the world who are interested in microtubule biology and its impact on human health and disease The microtubule cytoskeleton is essential for a wide variety of cellular functions such as chromosome segregation directed vesicle and organelle transport cell motility and cell polarity Impaired microtubule function can lead to human diseases including cancer and neurodegenerative disorders where microtubules serve as important therapeutic targets In recent years interdisciplinary approaches embracing cell biology genetics molecular biology biochemistry biophysics structural biology and mathematical modelling have made a tremendous impact on microtubule research The progressive diversification of the microtubule field creates the need for this strong meeting that unifies the community and brings together researchers from different disciplines interested in microtubule research As per the now well established format the 2024 edition of the symposium will feature inspirational keynote and landmark lectures a large number of short talk opportunities selected from the submitted abstracts lively poster sessions and activities for networking Session Topics Patterning of microtubule arrays Microtubule based control of cell architecture Microtubule motors and their regulation Microtubule biophysics Tubul ins and outs Microtubules in neurons Microtubules in cell division What past participants say about the conference Wonderful meeting that integrates the latest biophysics and cell biology An opportunity for extended discussion with emerging leaders of the field Tim Mitchson Harvard Medical School USA Great meeting that gathers a wonderful community in very fruitful discussions and networking A must repeat Ana Pimenta Marques University Nova de Lisboa Portugal This conference provided a space for stimulating scientific discussions and constructive feedback A great community to be a part of Veronica Farmer Vanderbilt University USA Speakers Keynote Nobutaka Hirokawa The University of Tokyo Japan Landmark lectures Anna Akhmanova Utrecht University The Netherlands Richard McIntosh University of Colorado Boulder USA Speakers Francesca Bartolini Columbia University USA Buzz Baum MRC Laboratory of Molecular Biology UK Renaud Chabrier LADIA France Paul Conduit Institut Jacques Monod France Filippo Del Bene Institut de la Vision France Judith Frydman Stanford University USA Ivana Gasic University of Geneva Switzerland Reto Gassmann Institute for Research and Innovation in Health i3S Portugal Edgar Gomes Instituto de Medicina Molecular Jo o Lobo Antunes Portugal Virginie Hamel University of Geneva Switzerland Xuan Li University of Cambridge UK Yu Chun Lin National Tsing Hua University Taiwan Jan L we MRC Laboratory of Molecular Biology UK Shinsuke Niwa Tohoku University Japan Simone Reber Max Planck Institute for Infection Biology Germany Stefanie Redemann University of Virginia USA Melina Schuh Max Planck Institute for Multidisciplinary Sciences Germany Yuta Shimamoto National Institute of Genetics Japan Phong Tran Institut Curie France Marija Zanic Vanderbilt University USA Jack Zhang Yale University USA Scientific organisers Carsten Janke Institut Curie France Thomas M ller Reichert Dresden University of Technology Germany Shinsuke Niwa Tohoku University Japan Kassandra Ori McKenney University of California Davis USA Conference organiser Chris Stocks Course and Conference Team Lead EMBL Heidelberg Germany Programme Are you on social media Post using EESMicrotubules and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 05 June 2024 Time Europe Berlin Speaker12 30 14 00Registration and light refreshments14 00 14 10Opening remarks14 10 15 55Session 1 Patterning of microtubule arraysChair Luke Rice University of Texas USA14 10 14 35The role of cytoskeleton in nuclear positioning and membrane remodeling during muscle formationEdgar Gomes Instituto de Medicina Molecular Jo o Lobo Antunes Portugal14 35 14 50Step wise assembly of axonemes visualised by cryo electron tomography of the ciliary tipHelen Foster Human Technopole Italy14 50 15 15Regulation of microtubule function in ischaemic heart failureXuan li University of Cambridge UK15 15 15 30Tubulin glutamylation patterns are central to axon guidance via selective tuning of microtubule severing enzymesCoralie Fassier Sorbonne Universit France15 30 15 55Precise control of microtubule structure and intracellular trafficking in living cells and behaving animalsYu Chun Lin National Tsing Hua University Taiwan15 55 16 25Coffee Break and Meet the speakers16 25 17 55Session 2 Emerging topics 1Chair Susanne Bechstedt McGill University Canada16 25 16 40Native structures of tubulin rich polymers from human parasite Toxoplasma gondiiRui Zhang Washington University USA16 40 16 55Robust cytoplasmic partitioning by solving an intrinsic cytoskeletal instabilityMelissa Rinaldin Technische Universit t Dresden Germany16 55 17 10Torque generation by mitotic motors in microtubule overlapsStefan Diez Technische Universit t Dresden Germany17 10 17 25Molecular interplay between HURP and Kif18A in the regulation of the mitotic spindleJuan Manuel Perez Bertoldi University of California Berkeley USA17 25 17 40Tubulin Code Generating recognition patterns to selectively direct Microtubule Associated ProteinsArya Krisnan Institut Curie FranceNot available on demand17 40 17 55Doublecortin and paclitaxel compete for control of microtubule lattice expansion and compactionGary Brouhard McGill University Canada17 55 20 00Dinner in Canteen20 00 22 00After dinner drinks poster preview Day 2 Thursday 06 June 2024 Time Europe Berlin Speaker09 00 09 45Landmark Lecture Microtubule plus end tracking proteins 25 years of cellular fireworksAnna Akhmanova Utrecht University The Netherlands09 45 10 15Coffee Break 10 15 12 00Session 3 Microtubule motors and their regulationChair Zdenek Lansky Institute of Biotechnology Czech Academy of Sciences Czech Republic10 15 10 40Animating microtubules by combining scientific drawing and programmingRenaud Chabrier Independent author artist and researcher10 40 10 55Stepping in two directions mechanisms that govern the bidirectional motility of mitotic kinesin motorsLeah Gheber Ben Gurion University of the Negev Israel10 55 11 20A novel adaptor for cytoplasmic dynein 1 regulates ER sheet organizationReto Gassman University of Porto Portugal11 20 11 45Activation of monomeric kinesinsShinsuke Niwa Tohoku University Japan11 45 12 00Cryo EM studies of cooperation between dynein dynactin and kinesin 1Sami Chaaban MRC Laboratory of Molecular Biology UK12 00 13 45Lunch meet the speakers13 45 14 45Session 4 Emerging Topics 2Chair Laura Schaedel Saarland University Germany13 45 14 00Microtubule and centrin networks enable ultrastructural plasticity in planktonic eukaryotesGautam Dey EMBL Heidelberg Germany14 00 14 15Cryo ET reveals actin filaments within platelet microtubulesChisato Tsuji University of Bristol UK14 15 14 30Investigating microtubule nucleation apparatus in plant cellsMasayoshi Nakamura Nagoya University Japan14 30 14 45Expanding the tubulin code through TTLL11 polyglutamylase activityJana Nedvedov Institute of Biotechnology of the Czech Academy of Sciences Czech Republic14 45 15 15Flash talks session 1 67 Subham Biswas 91 Takahiro Deguchi 97 Marcos Fari a Mosquera 123 Carla Jaramillo 139 Thibault Legal 151 Eleonora Messuti 153 Aniruddha Mitra 161 Shweta Nandakumar 171 Yannes Popp 179 Mariana Romeiro Motta 197 Sarah Steffens 199 Bhagyanath Suresh 205 Emma van Grinsven 213 Yucheng Ye 217 Guoli Zhao15 15 15 45Coffee Break and Meet the speakers15 45 18 30Poster Session 1 odd numbers with beer and snacks18 30 20 00Dinner in EMBL Canteen20 00 20 45Keynote 1The kinesin superfamily molecular motors and intracellular transport from regulation of brain functions and development to related diseasesNobutaka Hirokawa The University of Tokyo Japan20 45 22 30Networking drinks Day 3 Friday 07 June 2024 Time Europe Berlin Speaker09 00 10 45Session 5 Microtubule BiophysicsChair Francois Nedelec University of Cambridge UK09 00 09 25Diverse cytomotive actins and tubulins share a polymerisation switch mechanism conferring robust dynamicsJan L we MRC Laboratory of Molecular Biology UK09 25 09 50CLASPs stabilize the pre catastrophe intermediate state between microtubule growth and shrinkageMarija Zanic Vanderbilt University USA09 50 10 15Towards a Complete Mechanochemical Cycle of Dynein 1 by High Resolution Cryo EMJack Zhang Yale University USA this talk is virtual 10 15 10 30Visualization of GTP hydrolysis in microtubulesTomohiro Shima University of Tokyo Japan10 30 10 45Non averaging structural analysis of microtubules using cryo ETHanjin Liu University of Tokyo Japan10 45 11 15Coffee Break and Meet the speakers11 15 13 00Session 6 Microtubules in neuronsChair Andreas Prokop The University of Manchester UK11 15 11 40Zebrafish as a model for the study of in vivo axonal transport in neurons and related disordersFillipo Del Bene Institut de la Vision FranceNot available on demand11 40 11 55Mechanotransduction control of axonal microtubule distributionShaul Yogev Yale School of Medicine USA11 55 12 20Of Axons and Microtubules Tales from the Tubulin CodeFrancesca Bartolini Columbia University USA12 20 12 35In vitro reconstitution of microtubule doublets by MAP6d1Dharshini Gopal Universit Grenoble France12 35 13 00Asymmetric microtubule nucleation from the Golgi in neuronsPaul Conduit Institut Jacques Monod France13 00 14 15Lunch14 15 15 00Landmark Lecture 2Microtubules as tracks and engines how scientific ideas emerge and evolveRichard McIntosh University of Colorado Boulder USA15 00 15 20Flash talks session 2 66 Anika Binder 78 Po Pang Chen 86 Sabina Colombo 96 Juan Estevez Gallego 128 Daria Khuntsariya 130 Alison Kickuth 140 Miguel Leung 146 Francesca Maci 168 Gera Pavlova 198 Simone Steilberg15 20 15 50Coffee Break and Meet the speakers15 50 16 40Roundtable discussion Gamma Tubulin Complexes Anna Akhmanova Utrecht University The NetherlandsPaul Conduit Institut Jacques Monod FranceKuo Chiang Hsia Institute of Molecular Biology TaiwanTarun Kapoor The Rockefeller University USAJens Luders Institute for Research in Biomedicine SpainThomas Surrey Centre for Genomic Regulation Spain16 40 19 00Poster Session 2 even numbers with beer and snacks19 00 00 00BBQ and conference party Day 4 Saturday 08 June 2024 Time Europe BerlinSpeaker09 30 11 15Session 7 Tubul ins and outsChair Jawdat Al Bassam University of California Davis USA09 30 09 55The TRiCky business of folding tubulinJudith Frydman Stanford University USANot available on demand09 55 10 10Ancestrally conserved methyl marks regulating neuronal function written on microtubules by the histone methyltransferase NSD3 MES 4Edward Pietryk Baylor College of Medicine USA10 10 10 35Autoregulated control of tubulin mRNA stabilityIvana Gasic University of Geneva SwitzerlandNot available on demand10 35 10 50Unveiling the tubulin code readers required for directed cell migrationMarin Barisic Danish Cancer Institute Denmark10 50 11 15Opportunities challenges Studying microtubules form ectothermsSimone Reber Max Planck Institute for Infection Biology GermanyNot available on demand11 15 11 45Coffee Break and Meet the speakers11 45 13 00Session 8 Microtubule based control of cell architectureChair Isabelle Arnal Grenoble Institute of Neuroscience France11 45 12 10The archaeal origins of the eukaryotic cytoskeletonBuzz Baum MRC Laboratory of Molecular Biology UKNot available on demand12 10 12 35Unveiling centriole architecture assembly using expansion microscopyVirginie Hamel University of Geneva SwitzerlandNot available on demand12 35 13 00Examining the material properties of the spindle apparatus in cell free Xenopus egg extractsYuta Shimamoto National Institute of Genetics Japan13 00 14 30Lunch14 30 16 15Session 9 Microtubules in cell divisionChair Rytis Prekeris University of Colorado USA14 30 14 55Chimeras of Kinesin 6 and Kinesin 14 reveal domain functions and properties that lead to aneuploidy in fission yeastPhong Tran Institut Curie France14 55 15 10Uncovering the molecular mechanism of central spindle symmetry breaking during asymmetric cell division with synthetic biologyLara Kr ger MRC Laboratory of Molecular Biology UK15 10 15 35Using 3D large scale electron tomography to study force generation in the mitotic spindleeStefanie Redemann University of Virginia USA15 35 15 50Midzone spindles reorganisation from metaphase to anaphase in vitroWei Ming Lim Centre for Genomic Regulation Spain15 50 16 15New insights into spindle assembly and aneuploidy in oocytesMelina Schuh Max Planck Institute for Multidisciplinary Sciences GermanyNot available on demand16 15 16 30Poster prizes16 30 16 45Closing remarks Practical infomation Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks live streamed and on demand and the facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Chris Stocks for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Wednesday 8 May 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 07 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 Conference shuttle bus is available here View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Sponsors Media partners EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Journal of Cell Science The Company of Biologists Journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Carsten Janke, Thomas Müller-Reichert, Shinsuke Niwa, Kassandra Ori-Mckenney

1 June - 8 June 2024

Structural characterisation of macromolecular complexes

Description OverviewSpeakers and trainersFinal programmePractical informationSponsorsMedia kit Overview Course overview Recent developments in cryo EM ET super resolution microscopy and protein structure prediction coupled with increasingly sophisticated methods of sample preparation have revolutionised structural biology Educating the next generation of researchers on how to strategically combine these disparate tools is critical for addressing the most challenging structural biology problems of the future Course participants will receive a comprehensive overview of state of the art structural methods with a focus on sample preparation characterisation and data integration strategies Key aspects covered by lectures and practicals include multi subunit protein expression in bacteria insect and mammalian cells isolation of native complexes and in vitro reconstitution of protein and protein nucleic acid complexes biochemical and biophysical characterization to assess stoichiometry and sample homogeneity 3D structure determination of macromolecular assemblies at different resolution regimes and the integration of data from multiple experimental sources X ray crystallography cryo EM SAXS NMR mass spectrometry smFRET and super resolution light microscopy The current edition of this long standing course refreshes the portfolio of speakers and topics including a new module on the strategic exploitation of the latest protein structure prediction methods Audience Advanced PhD students and postdocs currently working on challenging projects in structural biology that would benefit form hybrid approaches Modules Protein expression and purification Biophysical characterisation of macromolecular complexes Introduction to electron microscopy X ray crystallography Small Angle X ray Scattering and serial crystallography using synchrotron radiation Application of Nuclear Magnetic Resonance in structural biology Mass spectrometry in protein protein interaction studies Single molecule methods and super resolution light microscopy AI based structure prediction methods Learning outcomes The primary goal of this course is to furnish participants with a comprehensive understanding of cutting edge methods employed in the structural characterization of macromolecular complexes Through over 20 thematic lectures participants will gain a solid theoretical foundation in the covered methods The course integrates hands on experience through experimental and computational practicals allowing participants to actively engage with a diverse range of methodologies discussed in the lectures The course will also feature several case studies presented by leading scientists within their respective fields to showcase applications of the methods covered in the course employed in diverse scientific contexts Ultimately participants will emerge from the course equipped with the strategic expertise to effectively integrate various tools enabling them to address the challenging structural biology problems of the future This course is jointly organised by EMBL Grenoble ESRF and IBS and practical sessions will take place at all three institutes located on the EPN Campus in Grenoble Speakers and trainers Mark Bates Institut f r Nanophotonik G ttingen Germany Janusz Bujnicki International Institute of Molecular and Cell Biology in Warsaw Poland Matthew Bowler EMBL Grenoble France Elena Conti Max Planck Institute of Biochemistry Germany Teresa Carlomagno University of Birmingham UK Luca Costa Centre de Biologie Structurale France Maria Hondele The Biozentrum University of Basel Switzerland Janet Iwasa University of Utah USA Remote speaker Cameron Mackereth University of Bordeaux France Julia Mahamid EMBL Heidelberg Germany Caroline Mas Institut de Biologie Structurale France Sigrid Milles Leibniz Forschungsinstitut f r Molekulare Pharmakologie im Forschungsverbund Berlin e V FMP Germany Alexandra Pacureanu European Synchrotron Radiation Facility France Anastassis Tassos Perrakis Netherlands Cancer Institute The Netherlands Randy Read University of Cambridge UK Kim Remans EMBL Heidelberg Germany Christophe Romier Institut de g n tique et de biologie mol culaire et cellulaire France Andrea Sinz Martin Luther University Halle Wittenberg Germany J rg Standfuss Paul Scherrer Institut Switzerland Martin Steinegger Seoul National University South Korea Song Tan Penn State University USA Rebecca Thompson Thermo Fisher Scientific UK Mark Tully European Synchrotron Radiation Facility France Trainers NameAffiliationShibom BasuEMBL GrenobleIskander KhusainovEMBL GrenobleEva KowalinskiEMBL GrenobleRomain LinaresEMBL GrenobleDaniele De SanctisEuropean Synchrotron Radiation Facility ESRF Eaazhisai KandiahEuropean Synchrotron Radiation Facility ESRF Hok Sau KwongEuropean Synchrotron Radiation Facility ESRF Mark TullyEuropean Synchrotron Radiation Facility ESRF Ana Casa alHuman TechnopoleAndrea GraziadelHuman TechnopoleCameron MackerethINSERMElisabetta Boeri ErbaInstitute de Biologie Structurale IBS Bernhard BrutscherInstitute de Biologie Structurale IBS Adrien FavierInstitute de Biologie Structurale IBS Aline Le RoyInstitute de Biologie Structurale IBS Caroline MasInstitute de Biologie Structurale IBS Philippe MasInstitute de Biologie Structurale IBS Felix WeisInstitute de Biologie Structurale IBS Scientific organisers Ana Casa al Human Technopole Italy Wojciech Galej EMBL Grenoble France Eva Kowalinski EMBL Grenoble France Carlo Petosa Institut de Biologie Structurale France Montserrat Soler Lopez European Synchrotron Radiation Facility ESRF France Elisabeth Zielonka EMBL Heidelberg German Course organisers Irena Provaznikova EMBL Heidelberg Germany Nathalie Sneider EMBL Heidelberg Germany Angelika Thomasson EMBL Grenoble France Final programme Are you on social media Post using EMBOMacromolecular and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours may be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Saturday 1 June 2024 Time Europe Grenoble SpeakerLocation12 00 12 30Arrival and registrationILL EMBL Hall12 30 13 30Buffet lunchILL EMBL Hall13 30 14 00Opening and course overviewEMBL Seminar room14 00 15 30Student presentations Part 1EMBL Seminar room15 30 16 00Coffee breakILL EMBL Hall16 00 17 30Student presentations Part 2EMBL Seminar room17 30 18 00BreakILL EMBL Hall18 00 18 45Lecture 1 Structural studies ofnucleosome binding complexesSong Tan The Pennsylvania State University USAEMBL Seminar room19 00 20 00Dinner at the EPN campusBouillon A Day 2 Sunday 2 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayWojciech Galej EMBL Grenoble FranceEMBL Seminar room09 00 09 45Lecture 2 Introduction to protein expression in E coliChristophe Romier Institut de g n tique et de biologie mol culaire et cellulaire FranceEMBL Seminar room09 45 10 30Lecture 3 Eukaryotic expression systemsKim Remans EMBL Heidelberg GermanyEMBL Seminar room10 30 11 00Coffee breakILL EMBL Hall11 00 11 45Lecture 4 Mass spectrometry in structural biologyAndrea Sinz Martin Luther University Halle Wittenberg GermanyEMBL Seminar room11 45 13 00Lunch breakCanteen13 00 19 00Social event visit to Vizille Castle19 00 21 00Group dinnerRestaurant Epicurien Day 3 Monday 3 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayCarlo Petosa Institut de Biologie Structurale FranceIBS09 00 09 45Lecture 5 Introduction to super resolution microscopyMark Bates Institut f r Nanophotonik G ttingen GermanyIBS09 45 10 30Lecture 6 Single molecule FRET in studying proteins interactions and dynamicsSigrid Milles Leibniz Forschungsinstitut f r Molekulare Pharmakologie im Forschungsverbund Berlin e V FMP GermanyIBS10 30 11 00Coffee break11 00 11 45Lecture 7 Introduction to small angle x ray scatteringMark Tully European Synchrotron Radiation Facility FranceIBS11 45 13 15Poster session 1ILL EMBL Hall13 15 14 15Lunch and networkingILL EMBL Hall14 15 16 15Parallel practical session 1Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsA EM intro P1 B Biophysics P9 C AF P10 D MS P7 Meeting point ILL EMBL Hall16 15 16 45Coffee breakILL EMBL Hall16 45 18 45Parallel practical session 2Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsB EM intro P1 A EM analysis P2 C Biophysics P9 D AF P10 Meeting point ILL EMBL Hall18 45 19 45DinnerCanteen Day 4 Tuesday 4 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayMontserrat Soler Lopez European Synchrotron Radiation Facility FranceIBS09 00 09 45Lecture 8 Introduction to automated synchrotron crystallographyMatthew Bowler EMBL Grenoble FranceIBS09 45 10 30Lecture 9 Serial X ray crystallographyJ rg Standfuss Paul Scherrer Institut USAIBS10 30 11 00Coffee breakIBS11 00 11 45Lecture 10 Structure prediction and modeling of RNAJanusz BujnickiInternational Institute of Molecular and Cell Biology in Warsaw PolandIBS11 45 12 30Lecture 11 Integrative structural biology of RNA proteincomplexesTeresa Carlomagno University of Birmingham UKIBS12 30 13 30LunchCanteen13 30 15 30Parallel practical session 3Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsD Biophysics P9 C EM intro P1 B EM analysis P2 A AF P10 Meeting point ILL EMBL Hall15 30 16 00Coffee breakILL EMBL Hall16 00 18 00Parallel practical session 4Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsA Biophysics P9 D EM intro P1 C EM analysis P2 B MS P7 Meeting point ILL EMBL Hall18 00 22 00Get together with PSB scientistsNetworking event with local PSB scientists with buffet dinner and drinksILL EMBL Hall Day 5 Wednesday 5 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayWojciech Galej EMBL Grenoble FranceIBS09 00 09 45Lecture 12 Introduction to cryo EM Rebecca Thompson Thermo Fisher Scientific UKIBS09 45 10 30Lecture 13 Cryo electron tomographyJulia Mahamid EMBL Heidelberg GermanyIBS10 30 11 00Coffee breakILL EMBL Hall11 00 12 30Poster session 2ILL EMBL Hall13 30 15 30Parallel practical session 5Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsA B NMR P3 C MS P7 D EM analysis P2 Meeting point ILL EMBL Hall15 30 16 00Coffee breakILL EMBL Hall16 00 18 00Parallel practical session 6Practicals C D A BParticipants divided into groups of 4attend one of the practical sessionsC D NMR P3 A MS P7 B AF P10 Meeting point ILL EMBL Hall18 00Free evening Day 6 Thursday 6 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayEva Kowalinski EMBL Grenoble FranceIBS09 00 09 45Lecture 14 Atomic Force MicroscopyLuca Costa Centre de Biologie Structurale FranceIBS09 45 10 30Lecture 15 Introduction to NMR spectroscopyCameron Mackereth University of Bordeaux FranceIBS10 30 11 00Coffee breakIBS11 00 11 45Lecture 16 Biophysical characterisation of protein complexesCarolina Mas Institut de Biologie Structurale FranceIBS11 45 12 30Lecture 17 Talk title TBCMartin Steinegger Seoul National University South KoreaIBS12 30 13 30LunchCanteen13 30 15 30Parallel practical session 7Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsA B Serial prep P5 C SAXS P4 D XL MS P8 Meeting point ILL EMBL Hall15 30 16 00Coffee breakILL EMBL Hall16 00 18 00Parallel practical session 8Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsA B Serial MX P6 D SAXS P4 C XL MS P8 Meeting point ILL EMBL Hall18 00DinnerLa Chapelle Restaurant Day 7 Friday 7 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayWojciech Galej EMBL Grenoble FranceIBS Seminar Room09 00 09 45Lecture 18 iNEXT discovery and and large infrastructures forstructural biologyAnastassis Tassos Perrakis Netherlands Cancer Institut The NetherlandsIBS Seminar Room09 45 10 30Lecture 19 Opportunities and challenges of AI methods in structuralbiologyRandy Read University of Cambridge UKIBS Seminar Room10 30 11 00Coffee breakIBS Seminar Room11 00 11 45Lecture 20 Mechanistic studies of theRNA surveillance pathwaysElena Conti Max Planck Institute of Biochemistry GermanyIBS Seminar Room11 45 12 30Panel discussion of responsible conduct of researchIBS Seminar Room12 30 13 30LunchCanteen13 30 15 30Parallel practical session 9Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsC D Serial prep P5 A SAXS P4 B XL MS P8 Meeting point ILL EMBL Hall15 30 16 00Coffee breakILL EMBL Hall16 00 18 00Parallel practical session 10Practicals A B C DParticipants divided into groups of 4attend one of the practical sessionsC D Serial MX P6 B SAXS P4 A XL MS P8 Meeting point ILL EMBL Hall18 00 18 30BreakILL EMBL Hall18 30 19 15Lecture 21 Structural datavisualisationJanet Iwasa University of Utah USA Virtual speaker EMBL Seminar room19 15 21 00Gala dinnerCorne d or Restaurant Day 8 Saturday 8 June 2024 Time Europe Grenoble SpeakerLocation08 45 09 00Overview of the dayCarlo Petosa Institut de Biologie Structurale FranceEMBL Seminar room09 00 09 45Lecture 22 X ray imaging in structural biologyAlexandra Pacureanu European Synchrotron Radiation Facility FranceEMBL Seminar room09 45 10 30Lecture 23 Phase separation and membraneless organellesMaria Hondele The Biozentrum University of Basel SwitzerlandEMBL Seminar room10 30 11 00Coffee breakILL EMBL Hall11 00 11 45Lecture 25 Structural studies of RNA protein complexesWojtek Galej EMBL Grenoble FranceEMBL Seminar room11 45 12 30Course evaluationEMBL Seminar room12 30 13 30LunchCanteen13 30Departure Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include accommodation location to be confirmed all meals throughout the duration of the course admission and course materials Travel expenses are NOT covered with the registration fee Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Hotel Reservations have been made for course participants at accommodation near the EMBL Grenoble site More details will be available soon Note accommodation is included in the registration fee Local transport Shuttle buses will go from the hotel to EMBL campus and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Grenoble 71 Av des Martyrs 38000 Grenoble FranceFrom Lyon Saint Exup ry Airport take the airport shuttle bus Lyon Saint Exup ry Grenoble counter Satobus inside the airport or in the bus A single ticket costs 22 a return ticket 33 The stop Place de la R sistance is within easy walking distance of the EMBL site From Grenoble take Tram B towards Resistance roundabout and exit at Grenoble Presquile The site entry is 350m away from the stop For further information on getting to EMBL Grenoble visit our Travel Information page Technical requirements and event software Technical requirements Information will be provided ahead of the course about installing any software required Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus COVID 19 related questions Updated information will be provided closer to the time as required Sponsors Event sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Ana Casanal, Wojciech Galej, Eva Kowalinski, Carlo Petosa, Montserrat Soler López

26 May - 31 May 2024

Whole transcriptome data analysis

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This course will teach the biological researchers how to analyse biological data sets using open source software Most of the analysis will be performed with docker4seq and rCASC packages which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis Docker4seq and rCASC packages use docker containers that embed demanding computing tasks e g short reads mapping into isolated containers This approach provides multiple advantages the user does not need to install all the software on its local server the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used for the analysis Computers for hands on exercises will be provided along with demo data sets Audience This course was developed for biological researchers as the intended audience Basic knowledge of massively parallel sequencing MPS is desirable however R coding skills and deep knowledge of statistics are not necessary What past participants say about the course My research focus is on RNA sequencing infectious diseases and next generation sequencing Attending this course helped me understand the basics got me career advice and extended my network Overall it made me a better researcher Abhay Deep Pandey Translational Health Science And Technology Institute India Excellent course on the complete spectrum of RNA Seq I would highly recommend this course to all biologists Issaac Rajan King Abdullah University of Science and Technology Saudi Arabia Speakers Marco Beccuti University of Turin Italy Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Scientific organisers Marco Beccuti University of Turin Italy Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Course organisers Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Training Lab Technician EMBL Heidelberg Germany Programme Are you on social media Post using EMBLDataAnalysis and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours may be required and if so will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 26 May 2024 Time Berlin Europe SpeakerLocation14 00 14 30Welcome and course overviewVladimir Benes EMBL Heidelberg GermanyCharlotte Courtney EMBL Heidelberg GermanyISG Hotel meeting room Weimar Dessau14 30 15 00Participants flash talksISG Hotel meeting room Weimar Dessau15 00 16 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyISG Hotel meeting room Weimar Dessau16 00 16 30Coffee BreakISG Hotel meeting room Weimar Dessau16 30 18 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyISG Hotel meeting room Weimar Dessau18 00 19 00DinnerISG Hotel beer garden Day 2 Monday 27 May 2024 Time Berlin Europe SpeakerLocation08 40Bus from ISG to EMBLISG Hotel entrance09 00 10 00Docker container and reproducibilityMarco Beccuti University of Turin ItalyComputer Training Lab10 00 10 30Coffee BreakATC Foyer10 30 11 00Experimental design bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab11 00 12 00QC bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Counting reads bulk RNAseqRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab14 30 15 00Coffee BreakATC Foyer15 00 17 30Counting reads miRNAFrancesca Cordero University of Turin ItalyComputer Training Lab17 30 18 30Social programme Facility tour18 30 19 30DinnerEMBL Canteen19 45Bus to ISG HotelATC Entrance Day 3 Tuesday 28 May 2024 Time Berlin Europe SpeakerLocation08 40Bus from ISG to EMBLISG Hotel entrance09 00 10 30PCA a linear dimensionality reduction methodRaffaele Calogero University of Turin ItalyComputer Training Lab10 30 11 00Coffee BreakATC Foyer11 00 12 30Differential expression analysis for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 14 30Differential expression analysis for multiple groups ANOVA likeRaffaele Calogero University of TurinComputer Training Lab14 30 16 00Visualising differentially expressed data Heat maps Raffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab16 00 16 30Coffee BreakATC Foyer16 30 18 00Mining differential expression results for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab18 00 19 00Pizza dinner in the Rooftop LoungeRooftop lounge19 00Bus to ISG HotelATC Entrance Day 4 Wednesday 29 May 2024 Time Berlin Europe SpeakerLocation08 40Bus from ISG to EMBLISG Hotel entrance09 00 10 00Exercises on Mining differential expression results for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab10 00 11 00Experimental design scRNAseqCounting reads single cells RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab11 00 11 30Coffee BreakATC Foyer11 30 12 30QC single cells RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab12 30 13 30Lunch and group photoEMBL Canteen13 30 15 00Non linear dimensionality reduction for single cell RNAseqRaffaele Calogero University of TurinComputer Training Lab15 00 16 00Sub population discovery in single cell RNAseq clusteringRaffaele Calogero Marco Beccuti University of Turin ItalyComputer Training Lab16 00 16 30Coffee BreakATC Foyer16 30 18 00Annotating cell types after sub population discoveryRaffaele Calogero University of Turin ItalyComputer Training Lab18 00Bus to ISG from EMBL ATC 20 minutes at ISG hotel to drop things ATC Entrance18 30Bus from ISG to Neckarm nzplatzISG Hotel19 00Downtown dinnerOskars Day 5 Thursday 30 May 2024 Time Berlin Europe SpeakerLocation08 40Bus from ISG to EMBLISG Hotel entrance09 00 10 00scRNA data integration Raffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab10 00 11 00ExercisesComputer Training Lab11 00 11 30Coffee BreakATC Foyer11 30 12 30Individual exercises on bulk RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Individual exercises on bulk RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab16 00 16 30Coffee BreakATC Foyer16 30 17 30Individual exercises on bulk RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab17 30 18 30Individual exercises on bulk RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab18 30 19 30DinnerEMBL Canteen19 30Bus to ISG HotelATC Entrance Day 6 Friday 31 May 2024 Time Berlin Europe SpeakerLocation08 40Bus from ISG to EMBLISG Hotel entrance09 00 11 00Individual exercises on single cell RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab11 00 11 30Coffee BreakATC Foyer11 30 12 30Individual exercises on single cell RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Individual exercises on single cell RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab16 00 16 20Final remarksVladimir Benes Raffaele Calogero Marco BeccutiComputer Training Lab16 30Bus to Heidelberg train stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 28 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 715PhD Student 715Industry 1225 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights from Saturday 25 May Friday 31 May 2024 at the ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course e g DAT24 01 by the deadline of Monday 29 April 2024 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Marco Beccuti, Vladimir Benes, Raffaele Calogero, Francesca Cordero

24 May 2024

Interpreting the effects of genetic variants on protein structure and function

Description Genetic variation between individuals results in a range of human phenotypes Variants that fall within coding regions of genes generally have direct effects on the proteins encoded by the genes with which they overlap This six hour virtual workshop will provide participants with an opportunity to gain hands on experience of using EMBL EBI tools and resources to assess the effects of genetic variants on the structure and function of proteins in a common workflow During the course a single example will be used throughout using different EMBL EBI tools and resources at each stage of the analysis pipeline The example will involve running a VCF file through the Ensembl Variant Effect Predictor VEP then following links to UniProt PDBe and AlphaFoldDB for further variant information and interpretation Virtual courseThis course will take place on Zoom Trainers will be available to assist during practical sessions answer questions and provide further explanations during the Zoom To join the course you will need to create an EMBL EBI Training website account...

Meredith Willmott

21 May - 23 May 2024

BioMalPar XX: biology and pathology of the malaria parasite

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Malaria remains a major global public health challenge The emergence and spread of resistance to existing antimalarial drugs further complicates the fight against this ancient foe As the BioMalPar Conference marks its 20th anniversary we would like to take a moment to reflect on the critical mission of understanding the biology of the Plasmodium parasite its interactions with hosts and vectors and the urgent need to develop effective intervention strategies This year we will focus on enhancing our research community by forging new connections We recognize that meaningful progress in combating malaria necessitates collaboration across continents and disciplines sharing data and employing state of the art techniques to unravel Plasmodium s secrets The upcoming conference is a pivotal opportunity for global scientists to convene fostering the exchange of vital information cutting edge technology and innovative ideas all crucial to advancing our collective battle against malaria Session topics Imaging Begins Revenge of the Mosquito Charlie the Vaccine Factory Mr Mrs Plasmodium V for Vivax The Parasite s Guide to the Galaxy What past participants say about the conference BioMalPar 2023 encompassed a spectacular range of research spanning basic to translational The program content was topical and comprehensive and the overall event was well organized to achieve a dynamic environment that fuelled great discussions and networking Jacquin Niles Massachusetts Institute of Technology USA After a decade working on malaria research I had heard high opinions of BioMalPar However this was my first time attending and clearly exceeded my expectations Excellent scientific content with a balanced blend of senior and junior scientists Smoothly organised in a venue that favours networking organically Alejandro Marin Menendez MIVEGEC IRD France Speakers Keynote Speaker Ally Olotu Ifakara Health Institute Tanzania Virtual speaker Speakers Takeshi Annoura National Institute of Infectious Diseases NIID Japan Nsa Dada Arizona State University USA Alfred Cort s ISGlobal Spain Emily Derbyshire Duke University USA Tibebu Habtewold Imperial College London UK Franziska Hentzschel Heidelberg University Hospital Germany Chi Min Ho Columbia University Irving Medical Center USA Felix Hol Radboud University Medical Center The Netherlands Mallika Imwong Mahidol University Thailand Virtual speaker Berlin Londo o Renteria Tulane University USA Fitsum G Tadesse Armauer Hansen Research Institute Ethiopia Moritz Treeck Gulbenkian Institute of Science Portugal Scientific Organisers Sabrina Absalon Indiana University School of Medicine USA Jessica Bryant Institut Pasteur France Fredros Okumu Ifakara Health Institute Tanzania Taco Kooij Radboud University Medical Center The Netherlands Emeritus steering group member Julian Rayner University of Cambridge UK Andy Waters University of Glasgow UK Conference Organiser Chris Stocks EMBL Heidelberg Germany Programme Are you on social media Post using EMBLMalaria and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 21 May 2024 Time Europe Berlin Speaker09 00 10 30Registration10 30 10 45Opening remarks10 45 11 45Keynote speaker A comprehensive approach to malaria elimination vaccines infrastructure and innovationAlly Olotu Ifakara Health Institute Tanzania Virtual speaker 11 45 15 15Session 1 Imaging Begins Chairs Nedal Djamil Darif EMBL Heidelberg GermanyMarkus Ganter Heidelberg University Germany 11 45 12 00A novel Dynamin interactor is required for malaria parasite apicoplast inheritanceJames Blauwkamp Indiana University School of Medicine USA12 00 12 15Imaging Plasmodium berghei gametocyte behaviour in the skinMatthew Gibbins University of Glasgow UK12 15 13 45Lunch and meet the speakers13 45 14 15Inhibiting elongation factor binding to the malarial 80S ribosome triggers ribosome biogenesisChi Min Ho Columbia University Irving Medical Center USA14 15 14 30Cryo EM structural analysis of broadly inhibitor antibodies against severe malaria associated PfEMP1Sai Sundar Rajan Raghavan The Scripps Research Institute USA14 30 14 45Multiple CENP C homologues are essential for mitosis and connect the inner kinetochore with chromosomes in malaria parasitesJessica Kimmel Bernhard Nocht Institute for Tropical Medicine Germany14 45 15 15Plasmodium cynomolgi an excellent model for imaging and valuable clue to understanding relapse and asymptomatic mechanisms in malaria endemic areasTakeshi Annoura National Institute of Infectious Diseases NIID Japan15 15 16 00Coffee break and meet the speakers16 00 17 30Session 2 V for Vivax Chairs Nicole Kilian California State University USAJerzy Dziekan Walter and Eliza Hall Institute of Medical Research Australia16 00 16 30What drives P vivax transmission Fitsum G Tadesse Armauer Hansen Research Institute Ethiopia16 30 16 45P vivax induced bone marrow alterations persist long after acute phase of infectionJoao Luiz Silva Filho University of Glasgow UK16 45 17 00Innocent residents or drivers of change investigating cell composition and interaction changes by Plasmodium infection in the bone marrow and spleenJoy Kabagenyi University of Glasgow UK17 00 17 30Anopheles gambiae population replacement using gene drive for malaria elimination in AfricaTibebu Habtewold Imperial College London UK17 30 17 55Flash talks 63 Luis Izquierdo 65 Ana Maria Filipe 75 Maria Ivanova 85 Patricia Landeau Millan 95 Hangjun Ke 97 Korbinian Niederm ller 99 Sarah Pashley 101 Christiaan van Ooij17 55 19 30Poster session 1 odd numbers 19 30 21 00Dinner21 00 22 30After dinner drinks in ATC Rooftop lounge Day 2 Wednesday 22 May 2024 Time Europe Berlin Speaker09 00 12 15Session 3 The Parasite s Guide to the Galaxy Chairs Caroline Ng University of Nebraska Medical Center USANicolas Brancucci Swiss TPH Switzerland09 00 09 30Interdisciplinary approaches to reveal Plasmodium parasite vulnerabilitiesEmily Derbyshire Duke University USA09 30 09 45Jumonji C demethylase 1 and 2 guardians of the euchromatin in Plasmodium falciparumJonas Gockel Radboud University The Netherlands09 45 10 00A metabolic switch controls ribosome heterogeneity in the human malaria parasiteJustine Couble Institut Pasteur France10 00 10 15A homing gRNA pilot screen in P berghei oocysts identifies a chloroquine resistance transporter like protein of the food vacuole essential for mosquito transmissionArjun Balakrishnan Ume University Sweden10 15 11 00Coffee break and meet the speakers11 00 11 30Expand Export Diversify and Conquer The FIKK kinase family in P falciparum host pathogen interactionMoritz Treeck The Francis Crick Institute UK and Gulbenkian Institute of Science PortugalNot available on demand11 30 11 45Stopping malaria parasites before they START aryl amino acetamides prevent ring development via inhibition of the lipid transfer protein PfSTART1Coralie Boulet Universit de Gen ve Switzerland11 45 12 00Plasmepsin V is essential for Plasmodium liver stage development via suppression of innate immunityEva Hesping Walter and Eliza Research Institute Australia12 00 12 15Order in chaos structural electron microscopy reveals the formation of a malarial maternal maintenance mechanism during ookinete developmentThanat Chookajorn Umea University Sweden Virtual short talk 12 15 13 45Lunch and meet the speakers13 45 17 00Session 4 Revenge of the Mosquito Chairs Wasim Hussein Heidelberg University Hospital GermanyLaura de Vries Harvard T H Chan Public School of Health USA13 45 14 15The mosquito microbiome the oft neglected component of malaria parasite vector interactionsNsa Dada Arizona State University USA14 15 14 30Malaria vector nutrition predicts rate of Plasmodium falciparum development and infectivityPhilipp Schwabl Harvard University USA14 30 14 45Characterization of Anopheles gambiae mosquitoes swarms using 3D video trackingRoberta Spaccapelo University of Perugia Italy14 45 15 00Flash talks 38 Jeffrey Agyapong 44 Ines Bento 98 Clara Eva Paquerau 110 Parul Singh15 00 15 45Coffee break and meet the speakers15 45 16 15Bloodthirsty Deep behavioral phenotyping reveals how mosquito pathogen interactions shape transmissionFelix Hol Radboud University Medical Center The Netherlands16 15 16 30Non CSP antibodies from immunized volunteers identify mosquito saliva proteins as a new target against P falciparum sporozoitesCarolina Andrade Radboud University Medical Center The Netherlands16 30 16 45Screen of diverse antimalarials reveals druggable Plasmodium falciparum targets for mosquito based malaria interventionAlexandra Probst Harvard T H Chan School of Public Health USA16 45 17 45Lifetime achievement award17 45 19 30Poster session 2 even numbers 19 30 21 00Dinner21 00 00 00After dinner drinks with Live music Day 3 Thursday 23 May 2024 Time Europe Berlin Speaker09 00 11 45Session 5 Mr Mrs Plasmodium Chairs David Guttery University of Leicester UKNisha Philip University of Edinburgh UK09 00 09 30Discovery of a divergent Arp2 3 complex essential for male gamete formation and transmissionFranziska Hentzschel Heidelberg University Hospital Germany09 30 09 45Microtubule inner proteins are essential for transmission of PlasmodiumAnnika Binder Heidelberg University Medical School Germany09 45 10 00Haemoglobin beta variants induce elevated Plasmodium falciparum sexual conversion rates in naturally infected individuals in Burkina FasoYasmina Drissi El Boukili Institute of Tropical Medicine Antwerp and University of Antwerp Belgium10 00 10 45Coffee break and meet the speakers10 45 11 15The regulation of the regulator of the regulator of the regulator of sexual conversion in Plasmodium falciparumAlfred Cort s ISGlobal Spain11 15 11 30Cryo EM of native Pfs230 and Pfs48 45 fertilisation complexMelanie H Dietrich Walter and Eliza Hall Institute of Medical Research University of Melbourne Australia11 30 11 45Mitochondrial ATP synthesis is essential for efficient gametogenesis in Plasmodium falciparumMichael Delves London School of Hygiene Tropical Medicine UK Virtual short talk 11 45 13 15Lunch and meet the speakers13 15 15 45Session 6 Charlie the Vaccine Factory Chairs Justin Boddey Walter and Eliza Hall Institute of Medical Research AustraliaNahla Galal Metwally Bernhard Nocht Institute for Tropical Medicine Germany13 15 13 45Evolution of multi drug resistant malaria implications on deployment of triple artemisinin based combination therapiesMallika Imwong Mahidol University Thailand Virtual speaker Not available on demand13 45 14 00Structure guided design of PfRH5 based vaccine immunogens for blood stage malariaNawsad Alam University of Oxford UK14 00 14 15The creation of pan African genetically attenuated Plasmodium falciparum sporozoite vaccines using experimental genetic crossesLucia Pazzagli Seattle Children s USA14 15 14 45Coffee break and meet the speakers14 45 15 00Safety and protection by a late liver stage attenuated malaria parasiteOlivia Lamers Leiden University Medical Center The NetherlandsNot available on demand15 00 15 15Fc afucosylation of VAR2CSA specific IgG and clinical protection against placental malariaMary Lopez Perez University of Copenhagen Denmark15 15 15 45Immune responses against mosquito saliva in chronic and infectious diseaseBerlin Londo o Renteria Tulane University USA15 45 16 00Closing remarks and poster prize announcements Practical information Choosing onsite vs virtual participation You can choose to attend the conference either onsite in Heidelberg or virtually If you hope to present your research you need to decide which mode suits you best before the abstract submission deadline considering the below If you plan to attend the conference onsite you can register and apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline Please note that once you have registered for onsite attendance and submitted an abstract for an oral presentation you will still have the opportunity to present a poster onsite even if not selected for an onsite oral presentation However it is not possible to switch and apply for a virtual oral presentation after the submission deadline If you plan to attend the conference virtually you can only apply for a virtual oral presentation as there will be no virtual posters If your abstract is not selected for a virtual oral presentation you can still participate in the conference with access to all the live streamed talks a video library of the recorded talks and a facility to submit questions Only participants attending the event onsite can present a poster Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 735On site PhD Student 635On site Industry 935On site Journal Editors 250Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact events embl de for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Onsite and virtual participants registering to attend are eligible to submit an abstract After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract The financial assistance for onsite participation 13 February 2024 Please note that the deadline for applying for financial assistance for BioMalPar is earlier than the abstract submission deadline This is to allow successful applicants more time to apply for a travel visa to enter Germany if needed In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Your abstract will still be considered if you are not awarded financial help and you may still attend on a self funding basis if you wish Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 23 April 2024 in some cases at special rates Please email the hotel directly quoting the booking code BMP23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 Conference shuttle bus schedule View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event You can find the bus schedule here Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners EMBO Molecular Medicine an EMBO Press journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Sabrina Absalon, Jess Bryant, Fredros Okumu, Taco Kooij

15 May 2024

Accessing sequence analysis tools via the new Job Dispatcher website

Description The Job Dispatcher team at EMBL EBI provides access to various bioinformatics sequence analysis tools EMBOSS Clustal omega NCBI BLAST etc and biological datasets This webinar will introduce the new Job Dispatcher website showcasing how to navigate through various categories of tools and access them for sequence analysis We will also demonstrate the latest features and user documentation of the Job Dispatcher...

14 May - 16 May 2024

Open Virtual Ensembl REST API Workshop

Description Work with Ensembl to master the Ensembl REST API and flexibly access genome wide data such as genes variants regulatory features homologues and alignments...

Louisse Paola Mirabueno

14 May - 17 May 2024

Cellular mechanisms driven by phase separation

Description OverviewSpeakersProgrammePractical informationSponsorsInstrument contestAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Phase separation is emerging as a common biophysical principle underlying many important cellular functions This conference will bring together scientists from cell biology biophysics biochemistry molecular biology structural biology developmental biology polymer physics and soft matter physics to study condensates in biology and disease The goals of this symposium are to increase our understanding of the physiological relevance of condensates in many biological processes explore the large repertoire of new tools and methods that can be applied to study the phenomenon of biological condensates provide transdisciplinary training to tackle the role of condensates in biology Session topics Membraneless compartments in the cell Molecular mechanisms of condensate assembly Phase separation a polymer physics perspective Condensates in cellular quality control Protein structure in the condensed state Condensates in gene expression Emerging technologies What past participants say about the Symposium I have never been to a conference where every single talk was relevant exciting and well done This is particularly phenomenal given the interdisciplinary nature of this field Carlos Castaneda Syracuse University USA Although Intrinsically Disordered Proteins and Phase Separation have been around for a number of years this meeting felt like the kick off for a novel area in molecular biology Roland Dosch University Medical Center G ttingen Germany This was the best conference I have attended in years bringing together biophysicists and biologists in an exciting and challenging format I learnt a lot and have made great contacts for new collaborations Sarah Mizielinska Kings College London UK Speakers Keynote Speakers Tanja Mittag St Jude Children s Research Hospital USA Rohit Pappu Washington University in St Louis USA Speakers Serena Carra University of Modena and Reggio Emilia Italy Amy Gladfelter Duke University USA Maria Hondele University of Basel Switzerland Anthony Hyman Max Planck Institute of Molecular Cell Biology and Genetics Germany Ankur Jain Whitehead Institute for Biomedical Research USA Tuomas Knowles University of Cambridge UK Hyun Kate Lee University of Toronto Canada Edward Lemke Institute of Molecular Biology and Johannes Gutenberg University Mainz Germany Tim Nott King s College London UK Michael Rosen The University of Texas Southwestern Medical Center USA Ritwick Sawarkar University of Cambridge UK Ben Schuler University of Zurich Switzerland Yongdae Shin Seoul National University Korea Agnes Toth Petroczy Max Planck Institute of Molecular Cell Biology and Genetics Germany Steph Weber McGill University Canada Scientific Organisers Simon Alberti Dresden University of Technology Germany Sara Cuylen H ring EMBL Heidelberg Germany Dorothee Dormann Institute of Molecular Biology and Johannes Gutenberg University Mainz Germany Alex Holehouse Washington University in St Louis USA Conference organiser Sophie Dutzi EMBL Heidelberg Germany Programme Are you on social media Post using EESPhaseSeparation and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 14 May 2024 Time Europe Berlin Speaker12 00 14 00Registration and light refreshments14 00 14 15Opening remarks 14 15 15 15Keynote lecture Interphases Interfaces and MicrophasesRohit Pappu Washington University in St Louis USA15 15 17 30Session 1 Membraneless compartments in the cellChair Sara Cuylen H ring EMBL Heidelberg Germany15 15 15 45Intracondensate demixing and the onset of diseaseTony Hyman Max Planck Institute of Molecular Cell Biology and Genetics Germany15 45 16 00Targeted perturbation of signaling driven condensatesJurian Schuijers UMC Utrecht The Netherlands16 00 16 15Nucleolus ejects internal components by altering its material properties upon arresting RNA fluxYuki Hayashi EMBL Heidelberg GermanyNot available on demand16 15 16 30Specificity of condensate composition regulates transcriptionBenjamin Sabari UT Southwestern Medical Center USA16 30 17 00Coffee break and meet the speakers17 00 17 30Identifying condensate forming proteins regardless of their structural disorder across organismsAgnes Toth Petroczy Max Planck Institute of Molecular Cell Biology and Genetics Germany17 30 18 00Flash Talk Session 1 125 Geng Jen Jang 127 Ramona J hlen 173 Stefan Niekam 175 Henri Niskanen 187 Aline Reuter 191 Tom Scheidt 201 Alexandra Shelest 203 Min Kyung Shinn 239 Theodore Yang 245 Jason Zhang18 00 19 30Poster Session 1 odd numbers 19 30 21 00Dinner in Canteen21 00 22 00After dinner drinks in ATC Foyer Day 2 Wednesday 15 May 2024 Time Europe Berlin Speaker09 00 11 15Session 2 Molecular mechanisms of condensate assemblyChair Alex Holehouse Washington University School of Medicine USA09 00 09 30Modulating DEAD box protein phase transitions with charge and ionsTim Nott King s College London UK09 30 09 45Surface condensation drives tight junction belt assembly in epithelial tissue sealingDaxiao Sun Technische Universit t Dresden MPI CBG Germany09 45 10 00Quantifying collective interactions in biomolecular phase separationHannes Ausserw ger University of Cambridge UK10 00 10 30Coffee break and meet the speakers10 30 10 45O GlcNAcylation and poly ADP ribosyl ation of protein IDRs two case studies in PTM dependent modulation of biomolecular condensatesMichael Nosella Hospital for Sick Children University of Toronto Canada10 45 11 15Internal Structure of Chromatin CondensatesMike Rosen The University of Texas Southwestern Medical Center USA11 15 13 00Session 3 Protein structure in the condensed stateChair Janosch Hennig EMBL Heidelberg Germany11 15 11 45Decoding molecular plasticity in the dark proteomeEdward Lemke Johannes Gutenberg University Mainz Institute of Molecular Biology IMB GermanyNot available on demand11 45 12 00A multiscale model of PopZ condensationKeren Lasker The Scripps Research Institute USANot available on demand12 00 12 15Lightning Condensates the electrochemical functions of biomolecular condensatesYifan Dai Washington University in St Louis USANot available on demand12 15 12 30Structural reorganization underlying yeast cytoplasmic solidificationMarie Christin Spindler EMBL Heidelberg Germany12 30 13 00Complex coacervation of highly charged IDPsBen Schuler University of Zurich SwitzerlandNot available on demand13 00 14 30Lunch and meet the editors14 30 16 45Session 4 Condensates and RNAChair Simon Alberti Technische Universit t Dresden Germany14 30 15 00Multiphase behavior of the nucleolus throughout the C elegans life cycleStephanie Weber McGill University Canada15 00 15 15Germ granule higher order organization coordinates their different functionsAli Haidar Institute of Human Genetics IGH University of Montpellier France15 15 15 30Multiscale multiphase condensates buffers mRNA variations to promote robust mRNA protein stoichiometryAmira Ouertani Universit C te D Azur CNRS Inserm iBV France15 30 16 00Coffee break and meet the speakers16 00 16 15Cold Induced Phase Separation of a Chloroplast RNAbinding proteinChristian Schmitz Linneweber Humboldt University Berlin Germany16 15 16 30Biomolecular condensates enable complex cellmorphology through localized translationZachary Geisterfer Duke University United States of America16 30 16 45TAF2 condensation in nuclear speckles links basal transcription factor TFIID to RNA splicingTanja Bhuiyan University of Freiburg Germany16 45 17 15Flash talk Session 2 73 Aritra Chowdhury 86 Nadia Erkamp 104 Marcos Gil Garcia 116 Clara Hipp 170 Ambuja Navalkar 176 Mihajlo Novakovic 198 Aleksandra Sergeeva 216 Laura Thomas 226 S ren von B low 240 Tianjin Yang17 15 18 45Poster Session 2 even numbers 18 45 20 30Dinner in Canteen 20 30 22 00After dinner drinks in ATC Foyer Day 3 Thursday 16 May 2024 Time Europe Berlin Speaker09 00 12 00Session 5 Condensates in cellular quality controlChair Dorothee Dormann Johannes Gutenberg University Mainz Germany09 00 09 30SUMO2 3 conjugation of TDP 43 protects against aggregationSerena Carra University of Modena and Reggio Emilia Italy09 30 09 45PARP1 DNA co condensation drives DNA repair site assembly to prevent disjunction of broken DNA endsNagaraja Chappidi Technische Universit t Dresden Germany09 45 10 00TERRA LSD1 phase separation promotes R loop formation for telomere maintenance in ALT cancer cellsHuaiying Zhang Carnegie Mellon University USA10 00 10 30Coffee break and meet the speakers10 30 11 00Sequence programmable nucleic acid condensatesAnkur Jain Whitehead Institute for Biomedical Research USA11 00 11 15Not just passive Active PKA inside stress granule regulates their maturation for the timely recovery after stressSonja Kroschwald ETH Zurich Switzerland11 15 11 45Regulation of stress induced condensates and their role in cell healthHyun Kate Lee University of Toronto Canada11 45 12 00PDIA6 condensates regulate ER stress signalingAnna Leder University of Basel Switzerland12 00 13 30Lunch13 30Free afternoon14 15 15 45Optional Guided City Tour of Heidelberg Registration onsite limited capacity available Meeting Point is Neckarm nzplatz Day 4 Friday 17 May 2024 Time Europe Berlin Speaker09 30 12 00Session 6 Condensates in gene expressionChair Sina Wittmann Institute of Molecular Biology Germany09 30 10 00The role of stress induced nuclear condensates of NELF in organismal physiologyRitwick Sawarkar University of Cambridge UK10 00 10 15Spatially controlled phase separation of MYC proteins as oncogenic principleMartin Eilers University of W rzburg GermanyNot available on demand10 15 10 30HP1a mediates chromatin miscibility in vitro driving spontaneous and reversible heterochromatin compartmentalizationLucy Brennan University of California Berkeley USA10 30 11 00Coffee break and meet the speakers11 00 11 15Stress granules reinforce the translation program of the integrated stress responseJarrett Smith Whitehead Institute USA11 15 11 45DEAD Box ATPases as regulators of RNA containing membraneless organellesMaria Hondele University of Basel SwitzerlandNot available on demand11 45 12 00Dissecting the contributions of D E tracts to setting up nucleolar pH gradients and complexities of complex coacervationMatthew King Washington University in St Louis USA12 00 14 00Lunch14 00 16 30Session 7 Emerging technologiesChair Julia Mahamid EMBL Heidelberg Germany14 00 14 30Molecular mechanisms of protein phase separationTuomas Knowles University of Cambridge UK14 30 14 45Systematic identification of condensate targets and development of condensate modifying drugs across therapeutic areasAvinash Patel Dewpoint Therapeutics USA14 45 15 00The phase separation landscape of genome wide genetic perturbationsMeta Heidenreich Weizmann Institute of Science Israel15 00 15 15Short linear motifs as condensation switchesSteven Boeynaems Baylor College of Medicine USANot available on demand15 15 15 45Coffee break and meet the speakers15 45 16 15Form and function in biomolecular condensationYongdae Shin Seoul National University Korea16 15 16 30Spatiotemporal control of chromatin associated condensate nucleationWilliam Jacobs Princeton University USA16 30 17 30Keynote lecture From physics to biology and back again How physical understanding of condensate properties can explain biological function and disease processesTanja Mittag St Jude Children s Hospital USA17 30 17 45Feedback Survey Session Q A 17 45 18 00Closing remarks and Poster prize18 00 20 00Conference Dinner in Canteen20 00 23 00Conference Party Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editor 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Sophie Dutzi for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 16 April 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 06 to confirm the exact price of the room Hotel AnlageHilton HeidelbergHotel MonptiB B HotelHotel Holl nder Hof Premier Inn Heidelberg CityHotel Bayrischer Hof Hotel ibis HeidelbergHotel Vier Jahreszeiten HeidelbergExzellenz HotelLeonardo Hotel Heidelberg City Centre Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 Conference shuttle bus schedule View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Gold sponsor Bronze sponsor Event supporter Media partners EMBO Reports an EMBO Press journal FEBS Letters FEBS Open Bio International Union of Biochemistry and Molecular Biology Journal of Cell Science The Company of Biologists Journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Instrument contest Labbot a Gold sponsor of the EMBO EMBL Symposium Cellular Mechanisms Driven by Phase Separation invites participants to submit their innovative research proposals for a chance to win a Labbot instrument valued at 49 000 Entries will be evaluated based on their creativity and potential impact in the field The submission process is straightforward requiring a simple registration and a concise project description The deadline for submissions is 16 May before 17 00 Winners will be announced on site on 17 May following the closing remarks For a summary of the contest and detailed instructions on how to participate please click on the link below Download contest description About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Simon Alberti, Sara Cuylen-Häring, Dorothee Dormann, Alex Holehouse

14 May - 17 May 2024

Introduction to metabolomics analysis

Description This course will provide an introduction to metabolomics through lectures and hands on sessions using publicly available data software and tools Participants will become familiar with standardised workflows as well as with the current state of experimental design data acquisition LC MS MS imaging processing and modelling In addition they will learn about community standards and sharing in metabolomics particularly through the use of EMBL EBI s MetaboLights repository and Galaxy infrastructure Participants will learn through hands on tutorials to use tools available for data analysis and data submission Additionally case studies will be discussed to show how to employ the week s learning...

Meredith Willmott

12 May - 17 May 2024

Advanced fluorescence imaging techniques

Description OverviewSpeakersProgrammePractical informationSponsorsMedia Kit Overview Course overview This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms Invited guest researchers together with microscopy experts from EMBL will foster an intense information flow with a balance of lectures and practical workshops The focus of the course will be on the use of fluorescence microscopy to obtain information about localisation and functions of proteins and other bio molecules at different spatial scales Audience This course is directed towards researchers in the life sciences with access to light microscopy equipment who have an immediate need to apply the techniques they will learn to solve biological problems at the cellular and molecular level in vivo As the course will be primarily focused on the advanced techniques we expect participants to have basic knowledge of light microscopy This course is organised in cooperation with Evident Modules Resources The topics will include fluorescence microscopy techniques such as fast time lapse microscopy of living cells spinning disk and point scanning confocal microscopy of large 3D samples photo manipulation as a tool multicolour single molecule localization microscopy SMLM with spectral demixing expansion microscopy FRET based techniques For demanding applications we will cover the aspects of image processing and analysis and the possibilities of microscope automation The modules will cover all necessary knowledge and demonstrate tools to conduct similar pipelines at your home lab enabling you to answer emerging biological questions Learning outcomes Get an overview of advanced fluorescence imaging techniques Obtain hands on experience setting up and running advanced experiments on modern fluorescence microscopes Discuss the possibilities and drawbacks of experiment planning and data interpretation with experts in the field This course is kindly supported by the EMBL Advanced Light Microscopy Facility This course is organised in cooperation with Evident What past participants say I highly recommend this course if you are looking to take your fluorescence microscopy experiments to the next level Josefina Marin Rojas Universidad de Chile Chile Speakers Speakers trainers and staff Yannick Nossin CellSignal The Netherlands Ipek Altinoglu Abbelight France Benjamin Compans Abbelight France Joana Delgado Martins University of Zurich Switzerland Claire Deo EMBL Heidelberg Germany Manuel Alexander Peter Gunkel EMBL Heidelberg Germany Aliaksandr Halavatyi EMBL Heidelberg Germany Mark Hink University of Amsterdam Netherlands Viktor Jakob Evident Germany Robert Kasper Evident Germany Muzamil Khan EMBL Heidelberg Germany Simone K hler EMBL Heidelberg Germany Marko Lampe EMBL Heidelberg Germany Stefan Marawske Evident Germany Felix Mikus EMBL Heidelberg Germany Kaarjel Narayanasamy EMBL Heidelberg Germany Pedro Pereira ITQB NOVA Portugal Marianna Poli Euro Bioimaging Germany Markus Sauer University of W rzburg Germany Stefan Terjung EMBL Heidelberg Germany Nikita Vladimirov University of Zurich Switzerland Urs Ziegler University of Zurich Switzerland Anja Zimmermann Rapp OptoElectronic GmbH Germany Scientific organisers Joana Delgado Martins University of Zurich Switzerland Aliaksandr Halavatyi EMBL Heidelberg Germany Stefan Marawske Evident Germany Course organisers Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Programme Programme Day 1 Sunday 12 May 2024 Time Europe Berlin SpeakerLocation15 30 16 00RegistrationISG Hotel Seminar Room Weimar16 00 16 30WelcomeISG Hotel Seminar Room Weimar16 30 19 00Flash talks by participantsISG Hotel Seminar Room Weimar19 00 21 00DinnerISG Hotel Day 2 Monday 13 May 2024 Time Europe Berlin SpeakerLocation08 35Bus from ISG Hotel to EMBLHotel entrance08 55 09 00EMBL introduction house notes and lab safetyCourtyard Room A B09 00 10 00Lecture Q A Concepts in Light microscopyUrs Ziegler University of Zurich SwitzerlandCourtyard Room A B10 00 11 00Lecture Q A DIY super resolution Expanding biology above diffractionPedro Matos Pereira ITQB PortugalCourtyard Room A B11 00 11 20Coffee BreakCourtyard Room A B11 20 12 05Lecture Q A Multimodal imaging driven insight into pulmonary fibrosis from model system to drug discoveryMuzamil Khan EMBL Heidelberg GermanyCourtyard Room A B12 05 12 30Lecture Q A Specificity is key A Spotlight on Cell Signaling Technology innovative solutions in multiplex IHCYannick Nossin CellSignal The NetherlandsCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 1 Live cell imagingJoana Delgado University of Zurich SwitzerlandUrs Ziegler University of Zurich Switzerland Groups 1 2 3D imaging of model organisms with CLSMStefan Terjung EMBL Heidelberg GermanyStefan Marawske Evident Germany Groups 3 4 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 45Hands on practical 2 3D imaging of model organisms with CLSM Stefan Terjung EMBL Heidelberg Germany Stefan Marawske Evident Germany Groups 1 2 Live cell imaging Joana Delgado University of Zurich Switzerland Urs Ziegler University of Zurich Switzerland Groups 1 2 Microscopy rooms 116 117Computer Training Lab18 45 19 45DinnerEMBL Canteen19 45Bus to HotelATC Entrance Day 3 Tuesday 14 May 2024 Time Europe Berlin SpeakerLocation08 35Bus from ISG Hotel to EMBLHotel entrance09 00 09 50Lecture Q A Adaptive Feedback MicroscopyAliaksandr Halavatyi EMBL Heidelberg GermanyCourtyard Room A B09 50 10 50Lecture Q A Visualizing chromosomes during meiosis Simone K hler EMBL Heidelberg GermanyCourtyard Room A B10 50 11 10Coffee breakCourtyard Room A B11 10 11 30Lecture How Euro BioImaging can support your research with access to the best imagingMarianna Poli Euro Bioimaging11 30 12 20Practical Setting and debugging adaptive feedback microscopy pipelinesManuel Gunkel EMBL Heidelberg GermanyComputer training lab12 20 13 15LunchEMBL Canteen13 15 13 30Group Photo13 30 16 00Hands on practical 3 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyManuel Gunkel EMBL Heidelberg Germany Group 1 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within Patient Tissues Muzamil Khan EMBL Heidelberg Germany Yannick Nossin CellSignal The Netherlands Group 2 DeconvolutionUrs Ziegler University of Zurich Switzerland Group 3 4 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 45Hands on practical 4 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypes Aliaksandr Halavatyi EMBL Heidelberg Germany Manuel Gunkel EMBL Heidelberg Germany Groups 3 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within Patient Tissues Muzamil Khan EMBL Heidelberg Germany Yannick Nossin CellSignal The Netherlands Group 4 Deconvolution Urs Ziegler University of Zurich Switzerland Groups 1 2 Computer training labMicroscopy rooms 116 11718 45 20 00Pizza dinner and informal discussionCourtyard rooms20 00Bus to HotelATC entrance Day 4 Wednesday 15 May 2024 Time Europe Berlin SpeakerLocation08 35Bus from ISG Hotel to EMBLHotel entrance09 00 09 45Lecture Q A Introduction to SMLM from concepts to samples Benjamin Compans Abbelight FranceCourtyard Room A B09 45 10 45Lecture Q A Measuring interactions and biosensors using FRETMark Hink University of Amsterdam The NetherlandsCourtyard Room A B10 45 11 15Coffee break11 15 12 30Practical Preparation of expansion microscopy samplesPedro Matos Pereira ITQB PortugalTraining Lab12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 5Multicolor Single molecule Localization Microscopy with Spectral Demixing Benjamin Compans Abbelight France Group 2 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within Patient Tissues Muzamil Khan EMBL Heidelberg Germany Yannick Nossin CellSignal The Netherlands Group 1 FRET Mark Hink University of Amsterdam The Netherlands Group 4 Imaging expanded samples Pedro Matos Pereira ITQB Portugal Group 3 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 45Hands on practical 6 Deciphering Spatial Patterns The Crucial Where in Multiplexed Immunofluorescence within Patient Tissues Muzamil Khan EMBL Heidelberg Germany Yannick Nossin CellSignal The Netherlands Group 3 Multicolor Single molecule Localization Microscopy with Spectral Demixing Benjamin Compans Abbelight France Group 4 Imaging expanded samples Pedro Matos Pereira ITQB Portugal Group 1 FRET Mark Hink University of Amsterdam The Netherlands Group 2 Microscopy rooms 116 11718 45 19 30Bus to dinner downtownATC entrance19 30 Dinner downtownGasthaus Zum Roten Ochsen Day 5 Thursday 16 May 2024 Time Europe Berlin SpeakerLocation08 35Bus from ISG Hotel to EMBLHotel entrance09 00 10 00Lecture Q A The Benchtop mesoSPIM a facility grade open source microscope for large cleared samples Nikita Vladimirov University of Zurich SwitzerlandCourtyard Room A B10 00 11 00Lecture Q A Small molecule fluorophores for biological imaging Claire Deo EMBL Heidelberg GermanyCourtyard Room A B11 00 11 30Coffee breakCourtyard Room A B11 30 12 30Lecture Q A True molecular resolution imaging Fluorescence imaging with a spatial resolution in the one digit nanometer range Markus Sauer University of W rzburg GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 7 FRET Mark Hink University of Amsterdam The Netherlands Group 3 Imaging expanded samples Pedro Matos Pereira ITQB Portugal Group 4 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypes Aliaksandr Halavatyi EMBL Heidelberg Germany Manuel Gunkel EMBL Heidelberg Germany Group 2 Multicolor Single molecule Localization Microscopy with Spectral Demixing Benjamin Compans Abbelight France Group 1 Microscopy rooms 116 11716 00 16 30Visit to The World of Molecular Biology ExhibitionImaging Center16 30 19 00Hands on practical 8 Imaging expanded samplesPedro Matos Pereira ITQB Portugal Group 2 FRET Mark Hink University of Amsterdam The Netherlands Group 1 Multicolor Single molecule Localization Microscopy with Spectral Demixing Benjamin Compans Abbelight France Group 3 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypes Aliaksandr Halavatyi EMBL Heidelberg Germany Manuel Gunkel EMBL Heidelberg Germany Group 4 Microscopy rooms 116 11719 00 20 00DinnerEMBL Canteen20 00 21 00Informal Q A discussion and drinksCourtyard Room A B21 00Departure to HotelATC entrance Day 6 Friday 17 May 2024 Time Europe Berlin SpeakerLocation08 35Bus from ISG Hotel to EMBLHotel Entrance09 00 10 30Practical FRET data analysisMark Hink University of Amsterdam The NetherlandsComputer training lab10 30 11 00Coffee breakoutside Computer training lab11 00 12 30Practical SMLM data analysisMarko Lampe EMBL Heidelberg GermanyComputer training lab12 30 13 30LunchEMBL Canteen13 30 14 40Preparation of student presentationsComputer training lab14 40 16 00Student presentationsComputer training lab16 00 16 30Wrap up of course and departureComputer training lab16 30Bus to ISG Hotel Heidelberg train station and city centerATC entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 625PhD Student 625Industry 1150 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 5 nights 12 17 May 2024 at ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with the booking code MIC24 02 by the deadline of 14 April 2024 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event Partners Event Sponsors Media partners Imaging and Microscopy a Wiley magazine Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media Kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Manuel Gunkel, Aliaksandr Halavatyi, Debora Keller-Olivier Joana Delgado Martins, Irina Rakotoson

9 May 2024

Exploring human disease and protein variant data in UniProtKB

Description UniProt KnowledgeBase UniProtKB supports biomedical research by providing a comprehensive high quality and freely accessible resource of protein sequence and functional information This webinar will provide an overview on how to access human disease and protein variant information available in UniProtKB It will outline the annotation of protein molecular function involvement in human disease as well as disease associated variants including variant position variant characterisation and their impact on protein structure and function It will present the protein variant viewer and feature viewer and demonstrate how the feature viewer facilitates visualisation of variant impact on protein features and 3D structure We will discuss the cross links to human specific databases and tools such as BLAST and Align In addition we will also demonstrate how to access and download human variation datasets available in UniProtKB By the end of this webinar attendees will have a solid foundation in navigating UniProtKB to access disease related protein data and utilising the various protein molecular data to analyse the impact of protein variants on protein function and structure...

8 May 2024

Wine yeasts as a model system in community ecology

Description Wine fermentation constitutes a transient microbial ecosystem wherein numerous yeast species originating from the grape surface engage in interactions This leads to an ecological succession anticipated to culminate in the ultimate dominance of Saccharomyces cerevisiae The diversity of yeast species found in grape musts has a direct impact on the final chemical and aroma complexity of the resulting wines Understanding the molecular and ecological interaction patterns between wine yeast communities is essential to harness diverse yeast functionalities with the final aim of producing tailored high quality wines In this webinar we will introduce the expectable phylogenetic and functional diversity in wine yeast communities we will discuss how to engineer wine yeast communities top down and bottom up and we will finally conclude about the necessity of adopting the adequate theoretical framework to address challenging questions in applied ecology and to finally improve microbiome based industrial processes You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionFirst global map of vineyard microbiomeBuilding a wine yeast collectionProspecting non conventional yeastQ A...

7 May - 9 May 2024

Open Virtual Ensembl Browser Workshop

Description Work with the Ensembl Outreach team to get to grips with the Ensembl browser accessing gene variation comparative genomics and regulation data and mine these data with BioMart...

Aleena Mushtaq

6 May - 8 May 2024

Building networks 2024: engineering in vascular biology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Barcelona Conference overview Blood vessels are essential for the formation and maintenance of larger tissues and organs The vascular system regulates exchange of oxygen nutrients and immune cells the dysfunction of which can cause severe pathologies Mouse models genetics and histology of human samples coupled with recent advances in imaging single cell approaches and computational modelling have provided significant knowledge to the field of vascular biology Yet in vivo models are highly complex and often need to be combined with simpler in vitro studies to get mechanistic and molecular insights Growth of in vitro blood vessels presents numerous research challenges due to their complex 3D geometry and a strong coupling between biology and mechanics Recent advances in microfluidic and 3D bioprinting offer a higher degree of control over design system components and biological function With the emergence and consolidation of these technologies together with human iPS cell technologies the vascular biology field is starting to model vascularized tissues and human vascular diseases in vitro In this meeting we intend to bring together vascular biologists and bioengineers from across the world to build research synergies to tackle long standing questions in the field of vascular biology Session topics Developmental vascular biology Vascular mechanobiology Aging in vascular biology Vascular integrity and thrombosis Vascular signaling and angiogenesis Lymphatics Vascular cardiobiology and engineering Speakers Keynote Speakers Christopher Chen Boston University USA Shulamit Levenberg Technion Israel Institute of Technology Israel Stefania Nicoli Yale University USA Speakers Irene Aspalter The Francis Crick Institute UK Abdul Barakat cole Polytechnique France Rui Benedito CNIC Spain Alexandre Dubrac University of Montreal Canada Maike Frye University Medical Center Hamburg Germany Kristina Haase EMBL Barcelona Spain Thomas Iskratsch Queen Mary University of London UK Anjali Kusumbe University of Oxford UK Riccardo Levato Utrecht University The Netherlands Tatiana Petrova University of Lausanne Switzerland Li Kun Phng RIKEN Center for Biosystems Dynamics Research Japan Shahin Rafii Weill Cornell USA Stefan Schulte Merker WWU M nster Germany Andy Shih Seattle Children s USA Virtual speaker Kelly Stevens University of Washington USA Oliver Stone University of Oxford UK Andries van der Meer University of Twente Netherlands Boyang Zhang McMaster University Canada Ying Zheng University of Washington USA Scientific Organisers Maria Bernabeu EMBL Barcelona Spain Cl udio Franco University of Lisbon Portugal Stephan Huveneers Amsterdam AMC Netherlands Milica Radisic University of Toronto Canada Conference Organisers Aline Schnieder EMBL Heidelberg Germany Silvia Autet Balcells EMBL Barcelona Spain Ina Grigorjeva EMBL Barcelona Spain Programme Are you on social media Post using EMBOBuildNetworks and don t forget to tag EMBLEvents Programme is preliminary and subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 0 Sunday 5 May 2024 Time Europe Barcelona 18 00Informal city tour optional Day 1 Monday 6 May 2024 Time Europe Barcelona Speaker09 00 09 45Registration and welcome coffee09 45 10 00Opening remarks by scientific organisers10 00 11 00Keynote lecture Engineering vasculature build learn repeatChristopher Chen Boston University USANot available on demandSession 1 Developmental vascular biologyChairs Claudio Franco and Li Kun Phng11 00 11 30Unraveling vascular development insights from single cell functional geneticsRui Benedito CNIC Spain11 30 11 45Reverse angiogenesis drives vascularization in distal lung budsMiram Meziane MIT Whitehead Institute USANot available on demand11 45 12 00Deep learning s journey through mouse retinal microscopy imagesHemaxi Narotamo Universidade Cat lica Portuguesa UCP Portugal12 00 12 30Engineering Kelly Stevens University of Washington USANot available on demand12 30 12 45Establishment of an in vitro morphogenetic process of non embedded endothelial self organization towards a lumenized capillaryAna Ximena Monroy Romero Universidad Aut noma de M xico Mexico12 45 14 15LunchFrom 13 15 concurrent lab tour Session 2 Vascular mechanobiologyChairs Christopher Chen and Stephan Huveneers14 15 14 45Endothelial mechano regulation in health and diseaseMaike Frye University Medical Center Hamburg Eppendorf GermanyNot available on demand14 45 15 00Primitive macrophages enhance a perivascular niche to enable vascular perfusion in human cardiac tissueShira Landau University of Toronto Canada15 00 15 15Forces mediate endothelial recruitment and reprogramming during CCM lesion growthApeksha Shapeti KU Leuven Belgium15 15 15 45Mechanical regulation of vascular smooth muscle cell phenotypic switching in arterial diseaseThomas Iskratsch Queen Mary University of London UK15 45 16 15Coffee break Meet the speakers16 15 16 45Light based bioprinting for perfusable engineered tissues and vascular modelsRiccardo Levato Utrecht University The NetherlandsNot available on demand16 45 17 00Biofabrication of perfusable and complex vascularization via sacrificial templating for tissue engineeringMatthias Ryma University of Bayreuth University Clinic W rzburg Germany17 00 17 30Combined forces of actin cytoskeleton and hydraulics in shaping blood vesselsLi kun Phng RIKEN Center for Biosystems Dynamics Research JapanNot available on demand17 30 18 00Flash talks 47 Roeland M H Merks 57 Hannah Fleckenstein 71 Aleksandra Kopacz 85 Fatemeh Mirzapour 89 L a Pinon18 00 20 00Poster session 1 odd numbers See the poster listing here Day 2 Tuesday 7 May 2024 Time Europe Barcelona Speaker07 00 08 00Group run optional 09 00 10 00Keynote lecture Localized multimerization of RNA sequences control cell migrationStefania Nicoli Yale University USASession 3 Aging in vascular biologyChair Tatiana Petrova10 00 10 30Optical dissection of brain capillary function Andy Shih Seattle Children s USA virtual speaker 10 30 10 45Human C peptide is a ligand of the elastin receptor complex and therewith central to vascular remodelling and disease in vascular agingGert Wensvoort Uit de Krempe IP BV The Netherlands10 45 11 15Vascular aging causes and consequencesAnjali Kusumbe University of Oxford UK11 15 11 45Coffee break meet the speakersSession 4 Vascular integrity and thrombosisChairs Maria Bernabeu and Andries van der Meer11 45 12 15Anatomical reconstruction of organ specific microvasculature and their applicationsYing Zheng University of Washington USA12 15 12 303D BBB a microfluidic model to investigate cellular and transcriptional changes after exposure to P falciparumLivia Piatti EMBL Barcelona12 30 12 45A fully iPSC derived human microfluidic 3D model of the blood brain barrier allows investigating mechanisms of neurovascular diseasesDominik Paquet University Hospital LMU Munich GermanyNot available on demand12 45 13 15In vitro blood vessels as platforms for studying vascular physiology and pathologyAbdul Barakat cole Polytechnique France13 15 14 45LunchFrom 13 45 concurrent lab tourSession 5 Vascular signaling and angiogenesisChairs Holger Gerhardt and Mariona Graupera14 45 15 15How to elect a leader Cellular decision making during sprouting angiogenesisIrene Aspalter The Francis Crick Institute UK15 15 15 30Engineering extracellular vesicles to permeabilize the blood brain barrierFrancesca Tomatis University of Coimbra Portugal15 30 16 00A molecular atlas of brain vascular interactions reveals a spatiotemporal requirement of TGF signaling in brain vascularizationAlexandre Dubrac University of Montreal Canada16 00 16 30Coffee break meet the speakers16 30 16 45Mechanosensory regulation of intestinal regeneration in Drosophila through the vascular stem cell nicheJessica Perochon University of Glasgow UK16 45 17 00The YAP TAZ Notch crosstalk determines angiogenesis mechanoregulation and its spatiotemporal control in silicoTomasso Ristori Eindhoven University of Technology The Netherlands17 00 17 30Engineering tissue specific human vascular network for organ repair and tumor targetingShahin Rafii Weill Cornell USA17 30 18 00Flash talks 48 Marta Cherubini 68 Urszula Kalucka 100 Sara Silva Pereira 106 Theano Tsikari 110 Pilar Villacampa18 00 20 00Poster session 2 even numbers See the poster listing here 20 00 22 00Conference dinner Day 3 Wednesday 8 May 2024 Time Europe Barcelona Speaker09 00 10 00Keynote lecture Engineering vascularized tissue flapsShulamit Levenberg Technion Israel Institute of Technology IsraelSession 6 LymphaticsChair Maike Frye10 00 10 30Applying the finishing touch VEGF C processing is a critical process for lymphangiogenesisStefan Schulte Merker WWU M nster GermanyNot available on demand10 30 11 00Coffee break Meet the speakers 11 00 11 30Direct specification of lymphatic endothelium from mesenchymal progenitorsOliver Stone University of Oxford UK11 30 11 45Biomaterial driven three dimensional lymphangiogenesis model using click gelatin hydrogelsDana E Al Ansari Imperial College London UKNot available on demand11 45 12 15Mechanisms of lymphatic vessel renewal and specializationTatiana Petrova University of Lausanne SwitzerlandNot available on demand12 15 13 45LunchSession 7 Vascular cardiobiology and engineeringChairs Kristina Haase and Milica Radisic13 45 14 15Tissue specific in vitro vascular models to study development and diseaseKristina Haase EMBL Barcelona SpainNot available on demand14 15 14 30Magnetically assembled arrays of microvascular networks on chipKatarzyna Rojek Polish Academy of Sciences Poland14 30 14 45Vascular smooth muscle cell phenotypic switching revealed in CADASIL patient derived iPSC 3D Vessel on Chip modelMarc Vila Cuenca Leiden University Medical Center The Netherlands14 45 15 15Unlocking the potential of organoid and tissue models for drug discovery with engineered vasculaturesBoyang Zhang McMaster University CanadaNot available on demand15 15 15 45Microfluidic vessels on chips for disease modelingAndries van der Meer University of Twente The NetherlandsNot available on demand15 45 16 00Closing Remarks and short talk poster prize awards Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 425On site PhD Student 325On site Industry 750On site Journal Editors 250Virtual Academia 200Virtual PhD Student 150Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Aline Schnieder for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Venue EMBL Barcelona is located at the Barcelona Biomedical Research Park PRBB The PRBB is located on Barceloneta seafront between Hospital del Mar and the Arts Hotel in the Olympic Port of Barcelona Address Barcelona Biomedical Research Park C Doctor Aiguader 88 08003 Barcelona The conference is taking place in the PRBB auditorium It is located on a raised level in the heart of the PRBB building overlooking the sea with independent access from the rest of the building Access to the Auditorium will be by the stairs located at the entrance of the inner square of the building For people with limited mobility the access through lifts up the 1st floor can be used While on campus please wear your conference badge at all times for security purposes PRBB EMBL Barcelona PhotoCredit Jordi Casa as EMBL Accommodation Accommodation is not included in the conference registration fee Below is a list of hotels that are located near the conference venue Please get in touch with them directly for availability and prices Please note that a city tax per person per night for the stay needs to be paid whether you book in a hotel or through Airbnb Hotel nameAddressBookingsH10 MarinaAvinguda del Bogatell 64 68 Olympic Village 08005 Barcelona map website Tel 34 933 09 79 17 reservas hmb h10hotels com H10 Port VellPas de Sota Muralla 9 08003 Barcelona map website Tel 34 933 10 30 65 reservas hpv h10hotels comH10 MontcadaVia Laietana 24 Ciutat Vella 08003 Barcelona map website Tel 34 932 68 85 70 reservas hm h10hotels comH10 UniversitatRonda de la Univ 21 L Eixample 08007 Barcelona map website Tel 34 933 42 78 50 reservas hu h10hotels comH10 UrquinaonaPl d Urquinaona 2 L Eixample 08010 Barcelona map website Tel 34 932 38 20 40 reservas2 hup h10hotels comHotel SB IcariaAv d Ic ria 195 08005 Barcelona map website Tel 34 932 21 82 00 reservations icaria sbhotels esHotel Ibis StylesCarrer de Llull 71 08005 Hb004742 Barcelona map website Tel 34 934 83 37 48 H9663 accor comMotel OnePg de Pujades 11 13 Sant Mart 08018 Barcelona map website Tel 34 936 26 19 00 iforteza motel one comDerby HotelsHotel Claris map website Hotel Granados map website Hotel Balmes map website Hotel Astoria map website Suites Avenue map website Tel 34 934 876 262 recepcionclaris derbyhotels com Tel 34 934 929 670 granados83 derbyhotels com Tel 34 934 511 914 balmes derbyhotels com Tel 34 932 098 311 astoria derbyhotels com Tel 34 934 874 159 recepsuitesavenue derbyhotels comRESA campus del Mar ResidenciaPg Salvat Papasseit 4 08003 Barcelona map website Tel 34 933 90 40 00 campusdelmar resa esRESA La Ciutadella ResidenciaPasseig Pujades 33 37 08018 Barcelona map website Tel 34 933 94 32 00 ciutadella resa es On site information Catering Lunches and coffee breaks are included in the registration fee The lunch buffets and coffee breaks will be set up in front of the Auditorium Snacks will be served on the first evening of the workshop during the Welcome reception PRBB terrace as well as during the poster sessions groundfloor beneath the Auditorium Dinners are at the participants own expense unless otherwise specified Please wear your badge at all times when serving yourself No food or drinks are allowed in the PRBB auditorium Electricity and charging station The mains voltage in Barcelona is 230 volts AC The flat European standard and the Schuko plug CEE 7 7 fit into the Spanish sockets Most Europeans do not need to buy an adapter plug for Spain Please note that there are no power outlets in the auditorium You can recharge your electronic devices at the reception area We kindly ask you to bring your own charger cables The charging station will be left unattended Health and safety notes Please read EMBL Barcelona s COVID 19 terms and conditions for events Smoking is prohibited in all PRBB facilities Eating and drinking is prohibited in the Auditorium Do not enter any restricted areas or the laboratories unless authorised to do so Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required Assist the casualty and provide first aid if trained to do so Take to Hospital del Mar Pg Maritim Barceloneta 23 31 OR Dial the emergency number 1020 from any internal phone OR Dial 112 Please report all accidents to the Conference Officer at the Registration Desk In case of fire Press the nearest fire alarm button or dial the emergency number 1020 from any internal phone There will be a loudspeaker announcement in Catalan Spanish English if an evacuation is required On hearing the evacuation message leave the building promptly following the escape route and exit signs and proceed to the meeting point Punto the reunion on Passeig Maritim Barceloneta next to the sea side Beyond first aid Please remember to bring your own medication if needed to the conference Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor Internet It is easy to access the internet via a wireless connection in any area of the building When connecting a mobile device the operating system automatically recognises the network PRBB The password for this network is darwin1809 The PRBB also participates in the Eduroam project which aims to allow network access for visitors from academic institutions associated with Eduroam Access to the service is always delivered with the same credentials as in the home institution Lost and found Lost and Found items are kept at Registration and will be stored at the EMBL Barcelona reception for a short whileafter the EMBO workshop Luggage There are no lockers available on site to store your belongings It is highly recommended to leave any valuables in your accommodation An unguarded wardrobe area is behind the registration desk You may use this wardrobe at the last day of the Workshop to store your luggage The venue is directly located at the beachside Be aware of your surroundings and belongings when leaving the building Phone numbers In case of emergency contact Security on the ground floor Ext 1020 0034933160020 Reception Ext 1000 or 0034933160000 Below are the most important emergency service phone numbers for Barcelona Fire service 080 Medical emergencies 061 Police Mossos d Esquadra 088 The Mossos d Esquadra are Catalonia s autonomous community police force They are responsible for crime investigations crime prevention and assistance at accident scenes Gu rdia Urbana 092 The Gu rdia Urbana are responsible for public order by patrollling the roads and streets They also look after traffic safety and control The Guardia Urbana are also the first point of call for everyday situations such as neighbourhood disputes like noise etc All general emergencies 112 If you become ill during the event please notify the Conference Officer s immediately Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Pickpockets It is highly recommended to leave any valuables in your accommodation The venue is located at the beachside which is a very busy area Be aware of your surroundings and belongings when leaving the building Sightseeing A variety of activities in Barcelona can be found in this website https www barcelona tourist guide com Time Spain operates on Central European time CET which means that the country is 6 hours ahead of eastern standard time EST in the United States and 1 hour ahead of Greenwich mean time GMT Travel to and from the venue Our EMBO Workshop partner hotel the H10 Marina is a 15 minutes walk to the venue If you prefer you can also take the bus The next bus stop is in 6 minutes walking distance to the hotel Line V27 is departing from Av Ic ria Joan Mir to Pg Mar tim Hospital del Mar From there it is another 3 minute walk Additionally a taxi stand is located just outside the hotel main entrance Hotel address Avinguda del Bogatell 64 68 Olympic Village 08005 Barcelona Useful Spanish expressions EnglishSpanishHelloHolaGood morning Good afternoon Good evening Good nightBuenos d as Buenas tardes Buenas noches Buenas nochesI m sorryLo siento PerdonaExcuse me Perd neme How are you C mo est s I m fine thanks And you Estoy bien gracias Y usted What is your name C mo te llamas My name isMe llamoDo you speak English Habla usted Ingl s I don t understandNo entiendoPlease speak more slowlyPor favor hable m s despacioThank youGraciasWhere is the toilet D nde est el servicio Please call me a taxiPuedes avisar llamar un taxi por favor How do I get to Como llego a A beer two beers please Una cerveza dos cervezas por favor A glass of red white wine pleaseUn vaso de vino tinto blanco por favor The menu please El men por favor Is there a local speciality Hay alguna especialidad local I m VegetarianSoy vegetariano aIt was deliciousEstaba deliciosoThe bill pleaseLa cuenta por favorI have a headacheMe duele la cabezaI have a sore throatTengo dolor de gargantaMy stomach hurtsMe duele el est magoI m allergic toSoy al rgico aI need a doctor who speaks EnglishNecesito un m dico que hable ingl s Transport information Getting to Barcelona By Plane Barcelona El Prat airport is located in El Prat de Llobregat just 12 km South West of the Barcelona city centre It has two passenger terminals Terminal 1 T1 and Terminal 2 T2 The airport has allocated airlines to terminals regardless of the destination of the flight Airport Transfers to the city centre The Aerob s is an express bus service that connects the Barcelona El Prat airport with the city centre Pla a Catalunya in 35 minutes You can take the Aerob s outside Terminal 1 A1 and Terminal 2 A2 This service runs every day of the year with departures between 5 and 15 minutes From the city centre you can take the metro or a bus to move around Barcelona The train service R2 line runs approximately every 30 minutes to and from Barcelona airport to the city centre The journey takes 25 minutes The train service operates from Terminal 2 T2 To get from T2 to T1 use the shuttle bus service Bus transit T1 T2 If you travel from the airport to the city centre you can get off at Barcelona Sants Passeig de Gr cia or Clot which are serviced by metro stops You can also take the metro line L9 orange from the airport It departs at Terminal 1 and connects at stations Torrassa L1 and L10 Sud Collblanc L5 and L10 Sud with metros to the city centre You will find a taxi rank outside any of the main terminal exits Look for the sign pointing to the nearest taxi rank All official Barcelona taxis are black and yellow and are required to charge you only the value on the taximeter plus any surcharge e g luggage or night The rates and surcharges are displayed inside the cab In Barcelona a taxi may be either ordered by phone found at authorised taxi rank or flagged down in the street Getting to Barcelona By train Barcelona Sants is the main train station for national and international arrivals and departures in Barcelona It is situated in pla a dels Pa sos Catalanes Barcelona National and regional trains also depart from Fran a station It is located at avinguda Marqu s de l Argentera s n Barcelona Spanish Railways RENFE Public Transport in Barcelona Metro and tram The metro network of Barcelona is very good and the trains are frequent and quick You do not have to worry about timetables Almost all attractions are within walking distance of a metro or tram station When there are no subways the gap can be filled by tram You can find the operating hours of the metro and tram here Buses The operating times of the buses are different for each line You will find a notice board with the timetable at each stop They operate from about 5 00 clock to about 22 00 clock Night bus NitBus Both the metro and the buses do not run all night In Barcelona there is a fairly dense network of night buses to get you back to your hotel all night long Except for the line N0 all lines stop at Pla a Catalunya and can change there The N0 line is a circular line that allows you to circle around the city center and change to the other NitBus The night buses are operated by the private operator AMB which is why the Barcelona Card and Hola BCN Ticket are not valid The N17 line goes to the airport The operating hours of the NitBus are different for each line but they run from about 22 00 to 05 00 clock Sponsors Bronze sponsor Media partners EMBO Journal an EMBO Press Journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsoring embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Maria Bernabeu, Claudio Franco, Stephan Huveneers, Milica Radisic

1 May 2024

Harmony in diversity: exploring the rich microbiomes of South American wildlife

Description Colombia and northern South America is known as a biodiversity hotspot but at the basis of that diversity is the microbial communities With recent advances in metagenomics the microbial communities and genomic composition has started to be characterised by unveiling a whole new world that is highly interconnected with macro organisms and the environment This webinar will illustrate the intricate world of microbial communities associated with diverse South American fauna From the high altitude realms of neotropical bumblebees to the depths of coral reefs we ll journey through the microbiome landscapes of beings like spectacled bears woolly monkeys lichens shrimps among others Discover the unseen connections shaping the health and resilience of these unique ecosystems You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionExploring microbial diversity in pacific coralsHow do probiotic species protect shrimp from disease The gut microbiota in Andean bearsMicrobiota diversity is related to dietary diversityMicrobial diversity during the fermentation of cacaoQ A...

24 April 2024

Introduction to the Ensembl Bacteria genome browser

Description Ensembl Bacteria is a browser for bacterial and archaeal genomes In this webinar we will explore Ensembl Bacteria to learn more about the latest data and where it came from view annotation of molecular interactions involving bacterial genes and comparative genomics data involving key bacterial species You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionWhy do we need genome browsers Ensembl Bacteria featuresTools in Ensembl BacteriaFinding a bacterial speciesHelp and documentation...

23 April - 26 April 2024

Organismal physiology

Description OverviewSpeakersPreliminary programmePractical informationSponsorsAbout Overview We regret to inform you that this event has been cancelled Please have a look at our other upcoming events here Symposium overview Like a machine any organism even the simplest is a functional unit coherent and integrated We are far from having elucidated in complex organisms the entire structure of these functional units A major outcome of research using model organisms has been to address this central question of biology that was stated so clearly and candidly by J Monod in 1969 Genetic studies in model organism have first revealed that we are far from knowing all the functions fulfilled by various organs in vertebrates or invertebrates In doing so this body of work has nonetheless led to unprecedented progress in our understanding of how homeostasis of an entire organism is maintained As a result modern physiology has slowly moved from a purely molecular discipline back to rediscovering its holistic nature The powerful combination of molecular and physiological approaches is revealing new insights into energy metabolism endocrinology cardiovascular and renal physiology as well as the regulation of cognitive and immune functions Symbiotic interactions with resident microbes have added a further dimension to the study of host physiology This symposium aims to provide a high visibility platform to scientists from multiple disciplines who use molecular genetic tools to probe inter organ communication signals that maintain homeostasis By bringing together scientists interested in various aspects of vertebrate and invertebrate animal physiology we will foster interactions between them that will accelerate the discovery of novel physiologies This meeting will also directly address a fundamental and long term goal of the study of physiology how can recent developments in whole organism physiology pave the way to novel adapted and efficient therapies for multiple degenerative diseases Picking up from where the virtual 2022 EMBO EMBL Symposium Inter organ communication in physiology and disease left off the 2024 event will bring together a new generation of scientists face to face to contribute critically to engaging in this emerging cross disciplinary field Session topics Physiology of behaviour Physiology of metabolism Neuroimmune interactions Physiological transitions and reproduction Organismal immunology Physiology of the gut and its microbes What past participants say about the Symposium Emerging important topic excellent science unpublished work discussed What you look for in conferences Let s meet for real next time Fran ois Leulier ENS de Lyon France I was very happy to be part of this first conference on inter organ communication I learned many new things Ionel Sandovici University of Cambridge UK Speakers Speakers Yasmine Belkaid National Institutes of Health NIH USA Esther Borges Florsheim Arizona State University USA Jens Br ning Max Planck Institute for Metabolism Research Germany Miguel Const ncia University of Cambridge UK Julia Cordero University of Glasgow UK Sidonia Fagarasan RIKEN Center for Integrative Medical Sciences Japan Ilana Gabanyi Instituto Gulbenkian de Ci ncia Portugal Anoj Ilanges Howard Hughes Medical Institute USA Yoav Livneh Weizmann Institute of Science Israel Lolitika Mandal Indian Institute of Science Education and Research Mohali India Elvira Mass Limes Institute Bonn Germany Ryusuke Niwa University of Tsukuba Japan Christoph Thaiss University of Pennsylvania USA David Tingley Harvard Medical School USA Sophie Ugolini Centre d immunologie de Marseille Luminy France Claire Wyart Paris Brain Institute France Scientific Organisers Gerard Karsenty Columbia University USA Irene Miguel Aliaga MRC London Institute of Medical Sciences and Imperial College London UK Asya Rolls Technion Israel Institute of Technology Israel Miguel Soares Instituto Gulbenkian de Ci ncia Portugal Conference organisers Luana Ribeiro EMBL Heidelberg Germany Preliminary programme Are you on social media Post using EMBLPhysio and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 23 April 2024 Time Europe Berlin Speaker12 30 14 00Registration and light refreshments14 00 14 15Opening remarks14 15 18 00Session 1 Physiology of metabolism14 15 14 45Hypothalamus dependent control of liver metabolismJens Bruning Max Planck Institute for Metabolism Research Germany14 45 15 00Selected short talk 115 00 15 15Selected short talk 215 15 16 00Coffee Break and Meet the speakers16 00 16 30A single cell homeostat for cellular excitabilityDavid Tingley Harvard Medical School USA16 30 16 45Selected short talk 316 45 17 00Selected short talk 417 00 18 00Poster sneak peek18 00 19 30Dinner in Canteen 19 30 21 00Pub Quiz in Canteen21 00 22 00After dinner drinks in the RTL Day 2 Wednesday 24 April 2024 Time Europe Berlin Speaker09 00 12 00Session 2 Physiology of behaviour09 00 09 30Talk title TBCAnoj Ilanges Howard Hughes Medical Institute USA09 30 09 45Selected short talk 509 45 10 00Selected short talk 610 00 10 30Coffee Break and Meet the speakers10 30 11 00Talk title TBCYoav Livneh Weizmann Institute of Science Israel11 00 11 15Selected short talk 711 15 11 45Talk title TBCClaire Wyart Paris Brain Institute France11 45 12 00Selected short talk 812 00 13 30Lunch 13 30 16 30Session 3 Physiological transitions and reproduction13 30 14 00Talk title TBCMiguel Constancia Wellcome MRC Institute of Metabolic Science University of Cambridge UK14 00 14 15Selected short talk 914 15 14 30Selected short talk 1014 30 15 00Coffee Break and Meet the speakers15 00 15 30Developmental Programming of Tissue Resident MacrophagesCElvira Mass Limes Institute Germany15 30 15 45Selected short talk 1115 45 16 00Selected short talk 1216 00 16 30Flash talks16 30 18 00Poster Session 1 odd numbers 18 00Free evening Day 3 Thursday 25 April 2024 Time Europe Berlin Speaker09 00 12 00Session 4 Neuroimmune interactions09 00 09 30Body brain communication in health and diseaseChristoph Thaiss University of Pennsylvania USA09 30 09 45Selected short talk 1309 45 10 00Selected short talk 1410 00 10 30Coffee Break and Meet the speakers10 30 11 00Talk title TBCSophie Ugolini Centre d immunologie de Marseille Luminy France11 00 11 15Selected short talk 1511 15 11 45Talk title TBCEsther Borges Florsheim Arizona State University USA11 45 12 00Selected short talk 1612 00 13 30Lunch 13 30 16 30Session 5 Organismal immunology13 30 14 00Talk title TBCLolitika Mandal Indian Institute of Science Education and Research India14 00 14 15Selected short talk 1714 15 14 30Selected short talk 1814 30 15 00Coffee Break and Meet the speakers15 00 15 30Neuronal sensing of bacterial compounds and their downstream effects on metabolismIlana Gabanyi Instituto Gulbenkian de Ci ncia Portugal15 30 15 45Selected short talk 1915 45 16 15Talk title TBCSidonia Fagarasan RIKEN Center for Integrative Medical Sciences Japan16 15 16 30Selected short talk 2016 30 17 00Flash talks17 00 18 30Poster Session 2 even numbers 18 30 20 30Conference Dinner 20 30 00 00Conference Party Day 4 Friday 26 April 2024 Time Europe Berlin Speaker09 00 12 00Session 6 Physiology of the gut and its microbes09 00 09 30Talk title TBCYasmine Belkaid Institut Pasteur France09 30 09 45Selected short talk 2109 45 10 15Talk title TBCJulia Cordero University of Glasgow UK10 15 10 45Coffee Break and Meet the speakers10 45 11 00Selected short talk 2211 00 11 30Talk title TBCRyusuke Niwa University of Tsukuba Japan11 30 11 45Selected short talk 2311 45 12 00Closing Remarks and Poster Prize Announcements12 00Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Luana Ribeiro for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Monday 25 March 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 05 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel MonptiHilton Heidelberg Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page Sponsors Event supporter Media partners EMBO Reports an EMBO Press journal FEBS Letters International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually...

Gerard Karsenty, Irene Miguel-Aliaga, Asya Rolls, Miguel Soares

22 April - 26 April 2024

Fundamentals of widefield and confocal microscopy and imaging

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Registration is not yet open for this event If you are interested in receiving more information please register your interest Course overview Light microscopy is the most widely used form of microscopy for life science research The correct handling of the microscope and optimising image quality e g contrast resolution as well as experimental design according to different applications are crucial to obtain the best results This course will provide the participants with an overview of the basics of microscopy light and optics contrast techniques and imaging The confocal part will include multicolour 3D and time lapse imaging as well as spectral imaging introduction to photobleaching and photoactivation techniques Basic image analysis tools including measurement functions colocalisation and spectral unmixing as well as 3D 4D image processing will be covered both in theory and practice The course will combine lectures with intense daily hands on practices followed by discussions Audience This course is directed towards PhD students and faculty searching for instruction on light microscopy and basic image processing with basic level on microscopy Learning outcomes Participants will get an overview of the basics of microscopy Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course This course is organised in cooperation with Evident Olympus Speakers Speakers trainers and staff Heiko Gaethje Evident Scientific Germany Stefan Marawske Evident Scientific Germany Jens Marquardt Evident Scientific Germany Stefan Terjung EMBL Heidelberg Germany Peter Vander Evident Scientific Germany Scientific organisers Heiko Gaethje Evident Scientific Germany Stefan Marawske Evident Scientific Germany Jens Marquardt Evident Scientific Germany Stefan Terjung EMBL Heidelberg Germany Course organisers Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBLWidefieldConfocal and don t forget to tag EMBLEvents Day 1 Monday 22 April 2024 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceB B Hotel09 00 09 15Arrival and welcome house notesCourtyard Room A B09 15 13 00Basics of optics and microscopy Theoretical basics of light and optics Types of microscope frames and types of optics Set up bright field microscopes and the appropriate optics for different needs Cleaning centering adjusting and operating a microscope Basic set up and use of imaging devicesHands on session 1Courtyard Room A B13 00 14 00LunchEMBL Canteen14 00 15 00Contrast methods Introduction into contrast methods phase contrast and differential interference contrast DIC Courtyard Room A B15 00 17 30Contrast methods set up and alignment Set up and use of contrast methods phase contrast and differential interference contrast DICHands on session 2Courtyard Room A B17 30 18 00Discussing open questionsCourtyard Room A B18 00 19 00DinnerEMBL Canteen19 00Departure to HotelATC Entrance Day 2 Tuesday 23 April 2024 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceB B Hotel08 50 09 00Arrival and coffeeCourtyard Room A B09 00 12 30Basics of digital imaging Adaptation of digital cameras and theiralignment Interpretation of image content histogram and digital filter functions Improving digital image contrastCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 16 00Fluorescence microscopy I Introduction to fluorescence microscopy Setting up of microscopes and cameras for fluorescence observation The different types of illumination sources e g mercury xenon metal halide or LED Cubes filters and objectives Find the appropriate filter combination for a given fluorochrome and applicationHands on session 3Courtyard Room A B16 00 17 30Discussing open questionsCourtyard Room A B17 30 18 30Pizza dinnerATC Rooftop Lounge18 30Departure to HotelATC Entrance Day 3 Wednesday 24 April 2024 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceB B Hotel08 50 09 00Arrival and coffeeCourtyard Room A B09 00 11 30Fluorescence microscopy II Auto fluorescence a source for noise Digital imaging for fluorescence microscopy Specific needs of digital cameras Digital multicolor handling Acquisition of multidimensional images 3D time Hands on session 3 continued Courtyard Room A B11 30 11 35Group picture11 35 12 30Guided tour of the EMBL Advanced light microscopy facility ALMF ALMF12 30 13 30LunchEMBL Canteen13 30 15 00Lecture Introduction to the confocal microscopeCourtyard Room A B15 00 18 00Hands on session Group work Different applications will be covered in small groups Module 1 Multicolor imagingModule 2 Photomanipulation techniques FRAP FLIP and PhotoconversionModule 3 3D image collection and enhancement zooming resolution SNR z stacks IMARIS basicModule 4 Time lapse imaging bleaching and viability Multi Area Time Lapses and StitchingMicroscopy rooms18 00 18 30EMBL Bus via ISG Hotel to downtownATC Entrance18 30 20 00Free time20 00 22 00Dinner downtownOskar Restaurant u Vinothek Day 4 Thursday 25 April 2024 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceB B Hotel08 50 09 00Arrival and coffeeCourtyard Room A B09 00 10 00FRAP and Photoconversion Talk Courtyard Room A B10 00 13 00Hands on session Group work Work in ModulesMicroscopy rooms13 00 14 00LunchEMBL Canteen14 00 18 00Hands on session Group work Comparative time lapse overnight experiment on three different setupsMicroscopy rooms18 00 19 00DinnerEMBL Canteen19 00Departure to HotelATC Entrance Day 5 Friday 26 April 2024 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceB B Hotel08 50 09 00Arrival and coffeeCourtyard Room A B09 00 09 30Evaluation and summaryof overnight timelapse acquisitionCourtyard Room A B09 30 12 30Hands on session Group work Work in ModulesMicroscopy rooms12 30 13 00Tips and tricks for data presentationCourtyard Room A B13 00 13 10Closing remarksCourtyard Room A B13 10 13 25Packed lunchATC Foyer13 25EMBL Bus via Hotel to main train stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 12 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 525PhD Student 525Industry 1050 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation Single rooms have been reserved for 5 nights 21 26 April at B B Hotel After the selection process selected participants should contact the hotel directly heidelberg hotelbb com to make a booking with the booking code MIC24 01 by the deadline of Monday 25 March We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EUR coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Imaging and Microscopy a Wiley magazine Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Heiko Gaethje, Jens Marquard

22 April - 26 April 2024

Microscopy data analysis: machine learning and the BioImage Archive

Description This virtual course will show how public bioimaging data resources centred around the BioImage Archive enable and enhance machine learning based image analysis The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi modal imaging data at the cell and tissue scale Participants will cover contemporary biological image analysis with an emphasis on machine learning methods as well as how to access and use images from databases Further instruction will be offered using applications such as ZeroCostDL4Mic ilastik the BioImage Model Zoo and CellProfiler Virtual course This course will be a virtual event delivered via a mixture of live streamed sessions pre recorded lectures and tutorials with live support We will be using Zoom to run the live sessions all fully password protected with automated English closed captioning and transcription with support and both scientific and social networking opportunities provided by Slack and other methods taking different time zones into account In order to make the most out of the course you should make sure to have a stable internet connection throughout the week and are available between 08 00 18 00 BST each day In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Selected participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course...

Meredith Willmott

17 April 2024

Statistical thinking for microbial ecology

Description Most microbial ecologists understand the importance of rigorous statistical analysis for conducting a replicable study However formal courses in the statistical analysis of high dimensional ecological data are rare and traditional courses in applied statistics may not teach skills applicable to modern microbiome analysis This webinar will introduce foundational concepts in statistics with a focus on applying these concepts to the analysis of modern microbiome datasets To illustrate these concepts we will use the field of differential abundance as a case study We will contrast popular differential abundance parameters and estimators specifically focusing on estimating meaningful contrasts using high throughput sequencing data You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionThree approaches to analysing dataCase study Microbial abundance parametersRadEmu and its applicationExamples of statistical tools suitable for different parametersQ A...

16 April - 20 April 2024

Computational Biology Training in Hematology 2024, Module 1

Description Computational Biology Training in Hematology CBTH provides early career researchers aiming to specialize in computational and quantitative biology aspects of hematology with a unique year long training and mentoring experience by top tier faculty CBTH is a joint effort of the European Hematology Association EHA and the European Molecular Biology Laboratory European Bioinformatics Institute EMBL EBI that aims to support the development of quantitative skills for hematology researchers through training and mentoring in computational biology The CBTH program will be organized with two multi day workshops in a city in Europe and a follow up session at the EHA Congress...

Sophie Spencer

15 April - 18 April 2024

The mechanics of life: from development to disease

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview The building blocks of life macromolecules cells tissues and organs act on each other via physical forces This interplay of physical forces between the units of life gives rise to complex behaviour enables motility transport growth division response to environmental cues and allows the exertion of forces on the environment bridging biological scales The alteration of forces and mechanical properties is associated with inflammation cancer and ageing This comprehensive symposium will study the interplay of the physical forces the mechanics between the fundamental building blocks of life from molecules to organs It will cover how these physical forces enable development and how they are altered in disease We will cover the physical mechanisms of the major components of the animal cell and its environment including cell membranes cytoskeleton the nucleus and the extracellular matrix It will focus on the role of mechanical forces in both development and disease engaging clinicians cell and developmental biologists and physical and material scientists from in silico to in vitro and to in vivo studies We will include state of the art technological applications that rely on the knowledge and use of mechanical forces for biotechnological and healthcare purposes Session Topics Subcellular mechanics Cellular dynamics and tissue organisation Multi tissue interaction Organismal morphogenesis Mechanobiology of disease Theoretical mechanobiology What past participants say about the Symposium Very well organized conference High level talks When you see an interesting topic for your research field and if it s organized by EMBL Don t hesitate go and enjoy Xiuyu Wang Universit de Paris France This conference served as great platform for me to showcase my work and gain usefulcomments and suggestions from the experts in my field I benefitted especially from theconference being mechanobiology focused but not too narrow in its scope in that it also traversed multiple scales as well development and diseased conditions This helped in networking with my peers and gaining crucial insight via expert talks I am already looking forward to the next edition of this meeting Abhishek Mukherjee National Institutes of Health USA As an early stage PhD student I have had a fantastic experience at this conference It was an incredible opportunity to develop connections and hear about the innovative and creative research being conducted across the mechanobiology community Rachel Mckeown University of Cambridge UK Speakers Keynote Speakers Guillaume Salbreux University of Geneva Switzerland Valerie Weaver University of California San Francisco USA Speakers Mariaceleste Aragona University of Copenhagen Denmark Ripla Arora Michigan State University USA Elias Barriga Dresden University of Technology Germany Otger Camp s Dresden University of Technology Germany Alberto Elosegui Artola The Francis Crick Institute UK Margaret Gardel The University of Chicago USA Frauke Gr ter Heidelberg Institute for Theoretical Studies Germany J r me Gros Institut Pasteur France Tsuyoshi Hirashima National University of Singapore Singapore Ana Maria Lennon Dum nil Institut Curie France Satoru Okuda Kanazawa University Japan Kate Poole The University of New South Wales Australia Rashmi Priya The Francis Crick Institute UK Mijo Simunovic Columbia University USA Iva Toli Ru er Bo kovi Institute Croatia Scientific Organisers Prisca Liberali Friedrich Miescher Institute for Biomedical Research Switzerland Nicoletta Petridou EMBL Heidelberg Germany Amy Shyer The Rockefeller University USA An ela ari Institute of Science and Technology Austria Xavier Trepat Institute of Bioengineering of Catalonia Spain Conference Organiser Maria Mercedes Bacadare Goitia EMBL Heidelberg Germany Programme Are you on social media Post using EESMechanobiology and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 15 April 2024 Time Europe Berlin Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 14 45Keynote speaker Interplay between inflammation anti tumor immunity and tissue tensionValerie Weaver University of California San Francisco USANot available on demand14 45 17 30Session 1Chairs Nicoletta Petridou EMBL Heidelberg GermanyAlberto Elosegui Artola The Francis Crick Institute UK14 45 15 15Epithelial folding irreversibility is controlled by elastoplastic transition via mechanosensitive actin bracket formationSatoru Okuda Kanazawa University JapanNot available on demand15 15 15 30Single cell physical phenotyping of mechanically dissociated tissue biopsies for fast diagnostic assessmentMarketa Kubankova Max Planck Institute for the Science of Light Max Planck Zentrum f r Physik und Medizin Germany15 30 15 45A mechanochemical model for symmetry breaking in regenerating Hydra spheroidsSera Weevers Friedrich Miescher Institute for Biomedical Research Switzerland15 45 16 30Coffee break and meet the speakers16 30 17 00Mechanobiology of chromosomal instability in cancerIva Toli Ru er Bo kovi Institute Croatia17 00 17 15Zebrafish trunk neural crest an in vivo model to understand collective migration under physiological mechanical compressionElena Scarpa University of Cambridge United Kingdom17 15 17 30Stress fluctuation as a regulator of mechanical competition in epithelial cellLucas Anger Institut Jacques Monod France17 30 18 30Poster sneak peek18 30 20 00Dinner in EMBL Canteen20 00 21 15After dinner drinks in ATC Rooftop lounge Day 2 Tuesday 16 April 2024 Time Europe Berlin Speaker09 30 12 30Session 2Chairs Prisca Liberali Friedrich Miescher Institute for Biomedical Research SwitzerlandSatoru Okuda Kanazawa University Japan09 30 10 00Multiscale mechanics of organ morphogenesisRashmi Priya The Francis Crick Institute UKNot available on demand10 00 10 15You are not encoded a biological theory of formAlan Rodrigues Rockefeller University United States of AmericaNot available on demand10 15 10 30Tissue scale mechanics control stem cell fate and positioning during epithelial developmentClementine Villeneuve Max Planck Institute for Molecular Biomedicine Germany10 30 11 00Coffee break and meet the speakers11 00 11 30Cell Shape Sensing in Immune CellsAna Maria Lennon Dum nil Institut Curie France11 30 11 45Extracellular matrix flow guides emergent in vitro epithelial organizationAbdel Rahman Abdel Fattah CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Austria11 45 12 00Spatial mechano transcriptomics of mouse embryogenesisAdrien Hallou University of Oxford United Kingdom12 00 12 30Form and function uterine 3D structure function relationships in early pregnancyRipla Arora Michigan State University USA12 30 14 00Lunch and meet the editors13 00 13 45Optional The World of Molecular Biology Exhibition at the Imaging Center Max 20 participants 14 00 16 30Session 3Chairs Amy Shyer The Rockefeller University USAPrisca Liberali Friedrich Miescher Institute for Biomedical Research Switzerland14 00 14 30The many roles of mechanics in shaping organismsOtger Camp s TU Dresden Germany14 30 14 45Dividing cells a minimal model for membrane constriction during cytokinesisIvan Palaia Institute of Science and Technology Austria Austria14 45 15 00Mechanical induction of bicephalous morphogenesis in HydraYamini Ravichandran University of Geneva Switzerland15 00 15 30Coffee break and meet the speakers15 30 16 00ERK mediated mechanical feedback for self organized tissue patterningTsuyoshi Hirashima National University of Singapore Singapore16 00 16 15Local decrease in cell wall mechanical stress as a possible trigger for cell splitting in Staphylococcus aureusSheila Hoshyaripour Friedrich Schiller University Jena Germany16 15 16 30Mechanisms of mechanical compartmentalisation in intestinal organoidsCl ment Hallopeau Institute for Bioengineering of Catalonia IBEC Spain16 30 17 00Flash talks 2 min each 43 Roberto Amadio 49 Matthew Bovyn 55 John Robert Davis 57 Bipasha Dey 65 Clara Gordillo Pi 77 Chrystian Junqueira Alves 99 Markus Mukenhirn 101 Ir ne Nagle 115 Magdalena Schindler 125 Yingyu Sun 127 Stefania Tavano17 00 18 30Poster Session 1 odd numbers 18 30 20 00Dinner in EMBL Canteen20 00 21 30After dinner drinks in ATC Rooftop lounge Day 3 Wednesday 17 April 2024 Time Europe Berlin Speaker09 30 12 30Session 4Chairs Xavier Trepat Institute of Bioengineering of Catalonia SpainRashmi Priya The Francis Crick Institute UK09 30 10 00Force sensing via ion channels in melanoma cellsKate Poole The University of New South Wales Australia10 00 10 15Lipid droplet segregation rigidifies embryo interior to dampen stress induced flows and ensure stable tissue deformation during gastrulationSameer Thukral RIKEN Biosystems Dynamics Research Japan10 15 10 30Mechanochemical coupling during intestinal crypt morphogenesisLaura Capolupo Friedrich Miescher Institute for Biomedical Research Switzerland10 30 11 00Coffee break and meet the speakers11 00 11 30Physical forces emerging from and for tissue morphogenesisElias Barriga TU Dresden Germany11 30 11 45Increased intraluminal pressure in liver disease changes hepatocyte polarity and functionCarlotta Mayer Max Planck Institute of Molecular Cell Biology and Genetics Germany11 45 12 00Mechanosensitive cell shape transition underlying epithelial tissue spreadingNaoya Hino Institute of Science and Technology Austria Austria12 00 12 30Mechanical feedback during embryonic self organizationJerome Gros Institut Pasteur France12 30 14 00Lunch and meet the editors13 00 13 45Optional The World of Molecular Biology Exhibition at the Imaging Center Max 20 participants 14 00 17 00Session 5Chairs Elias Barriga Instituto Gulbenkian De Ci ncia PortugalAna Maria Lennon Dum nil Institut Curie France14 00 14 30The role of the ECM viscoelasticity in development and diseaseAlberto Elosegui Artola The Francis Crick Institute UKNot available on demand14 30 14 45Histone serotonylation mediates collective migration via mechanics in vivoJoana Saraiva Instituto Gulbenkian Ci ncia Portugal14 45 15 00The role of Piezo1 mediated mechanosensing in natural killer cells and T cellsBin Qu Saarland University Germany15 00 15 30Coffee break and meet the speakers15 30 16 00How tissues convert physical forces into chemical cues directly protein mechanoradicalsFrauke Gr ter Heidelberg Institute for Theoretical Science Germany16 00 16 15Pattern analysis and emergence in axolotl limb growthEster Comellas Universitat Polit cnica de Catalunya Spain16 15 16 30Tissue architecture as a regulator of the length scales and time scales of morphogen signallingCamilla Autorino EMBL Heidelberg Germany16 30 17 00A slingshot through time reconstituting the first steps of mammalian embryo development with stem cellsMijo Simunovic Columbia University USA17 00 17 30Flash talks 2 min each 48 Arthur Boutillon 52 Denis Krndija 54 Jean Fran ois Darrigrand 66 Valeriia Grudtsyna 72 Alejandro Clemente 96 Carl Modes 112 Sirio Dupont 138 Tom Schultheiss17 30 19 00Poster Session 2 even numbers 19 00 20 30Conference Dinner in EMBL Canteen20 30 23 00Conference Party Day 4 Thursday 18 April 2024 Time Europe Berlin Speaker09 30 13 10Session 6 Chairs An ela ari Institute of Science and Technology AustriaNicoletta Petridou EMBL Heidelberg Germany09 30 10 00Control of cell shape and proliferation in epithelial tissueMargaret Gardel The University of Chicago USA10 00 10 15Morphogen transport in tissues as active porous mediaDiana Khoromskaia The Francis Crick Institute United Kingdom10 15 10 30A Brillouin twist for gastrulation The dynamics of cell mechanical properties in embryonic cell populationsJuan Manuel Gomez EMBL Heidelberg Germany10 30 11 00Coffee break and meet the speakers11 00 11 30Exploring the cellular and molecular mechanisms controlling stretch mediated tissue expansion in vivoMariaceleste Aragona University of Copenhagen DenmarkNot available on demand11 30 11 45Mechanical profiling of intracellular compartments in embryonic cell lineagesSantiago Ortiz Institute of Photonic Sciences Spain11 45 12 00Topographies of lipid membranes are biophysical regulators for the spatial organization of liquid protein condensatesKatja Zieske Max Planck Institute for the Science of Light GermanyNot available on demand12 00 13 00Keynote speaker active surfaces and biological morphogenesisGuillaume Salbreux University of Geneva Switzerland13 00 13 10Closing remarks and poster prize announcements13 10Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 675On site Industry 925On site Journal Editor 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Maria Bacadare for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 18 March 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 03 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder HofHotel MonptiHilton Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 Conference shuttle bus schedule View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event sponsor Event supporter Media partners EMBO Journal an EMBO Press Journal Development The Company of Biologists Journal Disease Models Mechanisms The Company of Biologists Journal FEBS Journal FEBS Letters International Union of Biochemistry and Molecular Biology Journal of Cell Science The Company of Biologists Journal Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Prisca Liberali, Nicoletta Petridou, Amy Shyer, Andela Saric, Xavier Trepat

15 April - 19 April 2024

Ultrastructure expansion microscopy

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Expansion microscopy ExM physically magnifies specimens allowing to obtain super resolution images using a conventional diffraction limited microscope such as confocal microscopy This powerful technique is easy to implement but it requires some hands on training The gain in resolution can be further enhanced with the use of super resolution microscopes such as STED This course centered on the Ultrastructure Expansion Microscopy U ExM based techniques applied to mammalian cells aims at disseminating and discussing expansion microscopy protocols and is intended for cell biologists parasitologists etc with applications ranging from tissue to cells Audience This course is intended for researchers ranging from PhD students to post docs and senior scientists as well as staff from bioimaging platforms who wish to establish expansion microscopy in their respective institutes Modules Resources Principles of expansion microscopy techniques with a focus on U ExM based techniques U ExM Cryo ExM iU ExM Learning outcomes After this course you should be able to Apply ultrastructure expansion microscopy on your own samples once back in your laboratory sample preparation and imaging Note that depending on your sample the preparation might slightly differ Spread the technique to your colleagues in their respective laboratories Choose the most appropriate expansion microscopy protocols for your needs What past participants say about the course The Expansion Microscopy course at EMBL was comprehensive and did an excellent job at introducing us to a variety of state of the art techniques whilst putting us in close contact with experts that discussed the best options for our specific samples to ensure a successful adaptation at our home institutes Alicia Cuber King s College London This course was the best I have ever attended with lots of practicals discussions and networking opportunities I feel ready to apply in my lab what I learnt from this course Marina Arbi University of Patras Greece This course has a recommendation rate of 100 by previous attendees The EMBL Imaging Centre training activities are generously supported by the Boehringer Ingelheim Foundation This event has been granted the following EMBO sustainability badge Grade 1 of 3 Speakers Speakers trainers and staff Sabrina Absalon Indiana University School of Medicine USA Luis Alvarez Leica Microsystems Germany Margarida Araujo EMBL Heidelberg Germany Enrico Atorino EMBL Heidelberg Germany Niccolo Banterle EMBL Heidelberg Germany Lor ne Bournonville University of Geneva Switzerland Gautam Dey EMBL Heidelberg Germany Paul Guichard University of Geneva Switzerland Virginie Hamel University of Geneva Switzerland Marine Laporte University of Lyon France Vincent Louvel University of Geneva Switzerland Felix Mikus EMBL Heidelberg Germany Ulf Schwartz Leica Microsystems Germany Ali Shaib University of G ttingen Medical Center Germany Caroline Simon EMBL Heidelberg Germany Johanna Tocci EMBL Heidelberg Germany Dietrich Walsh EMBL Heidelberg Germany Timo Zimmermann EMBL Heidelberg Germany Scientific organisers Niccolo Banterle EMBL Heidelberg Germany Gautam Dey EMBL Heidelberg Germany Paul Guichard University of Geneva Switzerland Virginie Hamel University of Geneva Switzerland Marine Laporte University of Lyon France Course organisers Iva Gavran Course and conference officer EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOExM and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 15 April 2024 Time Berlin Germany SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00RegistrationCourtyard room A B09 00 09 15EMBL introduction and House notes including safety rules Courtyard room A B09 15 09 30Course overviewVirginie Hamel University of Geneva SwitzerlandCourtyard room A B09 30 10 15Overview of ultrastructure expansion microscopy methodsPaul Guichard University of Geneva SwitzerlandCourtyard room A B10 15 10 45Coffee breakCourtyard room Foyer10 45 11 45Flash talks from all participantsCourtyard room A B11 45 12 15Ice breaking activity Challenges and expectationsEMBL Scientific Training TeamCourtyard room A B12 15 13 15Lunch BreakEMBL Canteen13 15 14 00UExM Step1 FixationiUExM Step 1 Fixation only cryo fixation Rotation of 3 stations Cryo fixation GROUP 1 Trainers Lor ne Bournonville Marine Laporte Enrico Atorino Chemical fixation MetOH PFA GA GROUP 2 Trainers Felix Mikus Margarida Araujo Caroline SimonIntroduction to practical 1 Expansion protocols GROUPS 3 4 Trainer Vincent Louvel Johanna TocciTraining Lab Flex lab14 00 14 45UExM Step1 FixationiUExM Step 1 Fixation only cryo fixation Rotation of 3 stations Cryo fixation GROUP 2 Trainers Lor ne Bournonville Marine Laporte Enrico AtorinoChemical fixation MetOH PFA GA GROUP 1 Trainers Felix Mikus Margarida Araujo Caroline SimonIntroduction to practical 1 Expansion protocols GROUPS 3 4 Trainer Vincent Louvel Johanna TocciTraining Lab Flex lab14 45 15 00Coffee breakCourtyard room Foyer15 00 15 45 One novel Expansion Microscopy techniqueAli H Shaib University of G ttingen Medical Center GermanyCourtyard room A B15 45 16 00Coffee breakCourtyard room Foyer16 00 16 45UExM Step1 FixationiUExM Step 1 Fixation only cryo fixation Rotation of 3 stations Cryo fixation GROUP 3 Trainers Lor ne Bournonville Marine Laporte Enrico Atorino Chemical fixation MetOH PFA GA GROUP 4 Trainers Felix Mikus Margarida Araujo Caroline SimonIntroduction to practical 1 Expansion protocols GROUPS 1 2 Trainer Vincent Louvel Johanna TocciTraining Lab Flex lab16 45 17 30UExM Step1 FixationiUExM Step 1 Fixation only cryo fixation Rotation of 3 stations Cryo fixation GROUP 4 Trainers Lor ne Bournonville Marine Laporte Enrico AtorinoChemical fixation MetOH PFA GA GROUP 3 Trainers Felix Mikus Margarida Araujo Caroline SimonIntroduction to practical 1 Expansion protocols GROUPS 1 2 Trainer Vincent Louvel Johanna TocciTraining Lab Flex lab17 30 19 00Tips Tricks with Pizza DinnerATC Rooftop Lounge19 00 19 10Shuttle bus to Hotel ISG from EMBLATC entrance Day 2 Tuesday 16 April 2024 Time Berlin Germany SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Overview of the dayCourtyard room A B09 00 09 15UExM and iUExM freeze substituion for cryo fixed samplesTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoCourtyard room A B09 15 10 00Cryo expansion microscopy Cryo ExM Marine Laporte University of Lyon FranceCourtyard room A B10 00 11 15UExM and iUExM rehydration of cryo fixed samplesUExM and iUExM Step 2 AnchoringiUExM gelation chamber preparationTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Flex lab11 15 11 30Coffee breakCourtyard room Foyer11 30 12 15Applications of U ExM to the Plasmodium falciparum parasiteSabrina Absalon Indiana University School of Medicine USACourtyard room A B12 15 12 30Group photo12 30 13 15Lunch breakEMBL Canteen13 15 14 15Poster session 1 Posters 1 8 Flex lab14 15 15 00UExM and iUExM GelationTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Flex lab15 00 15 30Coffee breakCourtyard room Foyer15 30 16 30UExM and iUExM DenaturationTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Flex lab16 30 17 30Poster session 1 POSTER 1 8 Flex lab17 30 18 30UExM and iUExM ExpansionTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Flex lab18 30 19 30Discussion on the responsible conduct of researchModerators Virginie Hamel and Paul GuichardCourtyard room A B19 30 20 30Dinner vegetarian EMBL Canteen20 30 20 40Shuttle bus to Hotel ISG from EMBLATC entrance Day 3 Wednesday 17 April 2024 Time Berlin Germany SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel 08 50 09 00Overview of the dayCourtyard room A B09 00 10 00UExM and iUExM immunostaining shrink in PBS and add 1 AntibodiesTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab 10 00 11 00Poster session 2 Posters 9 16 Flex lab11 00 11 15Coffee breakCourtyard room Foyer11 15 12 15Poster session 2 Posters 9 16 Flex lab12 15 13 15Lunch breakEMBL Canteen13 15 14 00UExM and iUExM immunostaining wash and add 2 AntibodiesTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab 14 00 14 45Applications of U ExM from centriole architecture to human pathologiesVirginie Hamel University of Geneva SwitzerlandCourtyard room A B14 45 15 15Coffee breakCourtyard room Foyer15 15 16 00World of Molecular Biology exhibitionEMBL Imaging centre16 00 16 45Yeast U ExM and beyondGautam Dey EMBL Heidelberg GermanyCourtyard room A B16 45 17 30UExM NHS stainingg oN change in protocol iUExM immunostaining wash and put in H20Trainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab 17 30 18 15Shuttle bus to Old town Heidelberg from EMBL with a 10 min stop at ISG hotel EMBL public bus stop 18 15 19 45Heidelberg Old Town tour19 45 21 45Downtown dinner Day 4 Thursday 18 April 2024 Time Berlin Germany SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Overview of the dayCourtyard room A B09 00 09 30iU ExM Neutral gel embeddingUExM washTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab09 30 10 30iU ExM Gelation Prepare anchoring solution and 2nd anchoringTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab10 30 11 00Coffee breakCourtyard room Foyer11 00 12 30Mounting U ExM 4x gels and First imaging sessionGroup 1 confocalGroup 2 confocalGroup 3 STEDGroup 4 STEDMicroscopy trainers Dietrich Walsh Timo Zimmermann Imaging Centre Ulf Schwarz Luis Alvarez Leica microsystems Trainers Niccol Banterle Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoMicroscopy room Imaging centre12 30 13 30Lunch breakEMBL Canteen13 30 15 00iU ExM Wash anchoring 2nd monomer solution embedding and 2nd gelationTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Flex lab15 00 15 15 Coffee breakCourtyard room Foyer15 15 16 30iU ExM DissolutionUExM 2nd imaging session Widefield Microscopy trainers Dietrich Walsh Timo Zimmermann Imaging Centre Ulf Schwarz Luis Alvarez Leica microsystems Trainers Niccol Banterle Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Imaging centre16 30 17 15iU ExM wash dissolutionTrainers Marine Laporte Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab17 15 17 30Coffee break Courtyard room Foyer17 30 19 30iU ExM final ExpansionUExM 3rd imaging sessionGroup 3 confocalGroup 4 confocalGroup 1 STEDGroup 2 STEDMicroscopy trainers Dietrich Walsh Timo Zimmermann Imaging Centre Ulf Schwarz Luis Alvarez Leica microsystems Trainers Niccol Banterle Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoTraining Lab Imaging centre19 30 20 30DinnerEMBL Canteen20 30 20 40Shuttle bus to Hotel ISG from EMBLATC entrance Day 5 Friday 19 April 2024 Tme Berlin Germany SpeakerLocation08 40 08 50Bus from hotel to EMBL ATC EntranceISG Hotel 08 50 09 00Overview of the dayCourtyard room A B09 00 11 00Imaging session iU ExM Widefield microscopes GROUP 1 2 Confocal STED microscopes GROUP 3 4 Microscopy trainers Dietrich Walsh Timo Zimmermann Imaging Centre Ulf Schwarz Luis Alvarez Leica microsystems Trainers Niccol Banterle Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoMicroscopy room11 00 11 15Coffee breakImaging centre11 15 12 45Imaging session iU ExM Widefield microscopes GROUP 3 4 Confocal STED microscopes GROUP 1 2 Microscopy trainers Dietrich Walsh Timo Zimmermann Imaging Centre Ulf Schwarz Luis Alvarez Leica microsystems Trainers Niccol Banterle Lor ne Bournonville Johanna Tocci Felix Mikus Margarida Araujo Vincent Louvel Caroline Simon Enrico AtorinoMicroscopy room12 45 13 30Lunch breakEMBL Canteen13 30 15 15Final discussion round course feedback poster prizes and closing remarksCourtyard room A B15 15 15 30Shuttle bus to Heidelberg train station ATC entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation in single rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 14 to 19 April 5 nights Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Add blockAdd block Group blocks together Select a layout Event Information Toggle panel Event InformationEvent organiser DefaultCCO HeidelbergScience and SocietyTREC Events Date Time Type Location Registration Abstract Additional information Template Start DateEnd Date Optional for multi day events Start TimeEnd TimeTime Zone Select Europe BerlinEurope LondonAmerica New York Europe London Event Block Paragraph Start with the basic building block of all narrative Colour Text Background Typography Font size SIZE S M L XL XXL Advanced Skip to the selected blockOpen publish panel Event VF Tabs VF Tab Section Details Paragraph Notifications Copied 5 blocks to clipboard Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Add blockAdd block Group blocks together Select a layout Event Information Toggle panel Event InformationEvent organiser DefaultCCO HeidelbergScience and SocietyTREC Events Date Time Type Location Registration Abstract Additional information Template Start DateEnd Date Optional for multi day events Start TimeEnd TimeTime Zone Select Europe BerlinEurope LondonAmerica New York Europe London Event Block Paragraph Start with the basic building block of all narrative Colour Text Background Typography Font size SIZE S M L XL XXL Advanced Skip to the selected blockOpen publish panel Event VF Tabs VF Tab Section Details Paragraph Notifications Copied 5 blocks to clipboard On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions and travelling to EMBL on our Information for Participants page Sponsors Event Partners Event Sponsors Media partners Imaging and Microscopy a Wiley magazine Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1080 Social 1600 900...

Niccolo Banterle, Gautam Dey, Paul Guichard, Virginie Hamel, Marine Laporte

11 April 2024

Curating proteins involved in Antimicrobial Resistance (AMR) in UniProt

Description UniProt is a comprehensive expert led publicly available database of protein sequence function and variation information This webinar will give a brief introduction to the UniProt website and then highlight resources which should be of interest to people beginning work on antimicrobial resistance AMR including students early stage researchers and clinicians AMR constitutes one of the world s most urgent public health problems We have been improving the annotation of various protein classes with a known role in AMR including beta lactamases efflux pumps ABC transporters and a group of proteins essential for the survival of resistant bacteria under therapeutic concentrations of antimicrobials collectively known as the secondary resistome Using these as examples we will introduce some of the UniProt resources UniProt annotations are widely disseminated to other databases including Rhea EnsemblBacteria PATRIC Bacterial Viral Bioinformatics Resource Center BioCyc EcoCyc and KEGG Please also take this opportunity to suggest additional curation targets to us to enable us to better support ongoing AMR research...

9 April - 12 April 2024

Diversity of plants: from genomes to metabolism

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview This inaugural EMBO EMBL Symposium will showcase the future of plant biology Going beyond the limited number of wild and crop plants that have historically been focused on modern comparative approaches are revealing the mechanistic bases and evolutionary forces driving the enormous phenotypic variation among the 400 000 plant species on Earth This conference is for biologists with an interest in plant diversity at the genomic epi genetic phenotypic and metabolic level The major topical threads will be the biology of genomes evolution of metabolic pathways and evolution of environment dependent and independent phenotypes which constitute some of the most exciting areas of contemporary biology Session topics Evolution of genomes Evolution of metabolism I Evolution of metabolism II Biology of genomes Plants in their environment Evolution of phenotypes Speakers Keynote speaker Anne Osbourn John Innes Centre UK Speakers Asaph Aharoni Weizmann Institute of Science Israel John Bowman Monash University Australia Andrea Br utigam Bielefeld University Germany C Robin Buell University of Georgia USA Christine Faulkner John Innes Centre UK Xiaoqi Feng Institute of Science and Technology Austria Austria Fernando Geu Flores University of Copenhagen Denmark Tonni Grube Andersen Max Planck Institute for Plant Breeding Research Germany Sanwen Huang Chinese Academy of Tropical Agricultural Sciences and Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences China Xiaoguang Lei Peking University China Edwige Moyroud University of Cambridge UK Leandro Quadrana IBENS Institut de Biologie de l cole Normale Sup rieure France Seung Yon Sue Rhee Michigan State University USA Virtual speaker Aleksandra Skirycz Michigan State University USA Noah Whiteman University of California Berkeley USA Scientific organisers Barbara Ann Halkier University of Copenhagen Denmark Sarah E O Connor Max Planck Institute for Chemical Ecology Germany Detlef Weigel Max Planck Institute for Biology Germany Conference organiser Nathalie Sneider EMBL Heidelberg Germany Programme Are you on social media Post using EESPlantDiversity and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Please find the poster listing here Day 1 Tuesday 9 April 2024 Time Europe Berlin Speaker12 00 13 30Registration and light refreshments13 30 13 45Opening remarks13 45 14 45Keynote lecture Harnessing plant metabolic diversity for food and health applicationsAnne Osbourn John Innes Centre UK 14 45 18 15Session 1 Evolution of genomesChaired by Justyna Lalak Kanczugowska Polish Academy of Sciences Poland14 45 15 15The reinvention of potatoSanwen Huang Chinese Academy of Tropical Agricultural Sciences Agricultural Genome Institute at Shenzhen Chinese Academy of Agricultural Sciences China15 15 15 30Widespread position dependent enhancers in plantsYoav Voichek Gregor Mendel Institue GMI Austria15 30 15 45Allelic variants determine plant microbe plant interactionsNiklas Schandry Ludwig Maximilians University Germany15 45 16 15Coffee Break and Meet the speakers with Anne Osbourn Sanwen Huang16 15 16 45Evolving by jumping the role of mobile DNA in the generation of adaptive variation in response to environmental challengesLeandro Quadrana IBENS Institut de Biologie de l cole Normale Sup rieure France16 45 17 00The metabolic and genomic imprints of unparalleled growthHaim Trebes Rheinland Pf lzische Technische Universit t Kaiserslautern Landau Germany Tel Aviv University Israel17 00 17 15Illuminating biology of the red algae the forgotten plant lineageMichael Borg Max Planck Institute for Biology T bingen GermanyNot available on demand17 15 18 15Poster sneak peek18 15 19 45Dinner19 45 21 30Pub Quiz in Canteen After dinner drinks in the Rooftop Lounge Day 2 Wednesday 10 April 2024 Time Europe Berlin Speaker09 00 12 00Session 2 Evolution of metabolism IChaired by Jiawen Chen KU Leuven Belgium John Innes Centre UK09 00 09 30Let s connect to nature and explore plant metabolism in a contextAsaph Aharoni Weizmann Institute of Science IsraelNot available on demand09 30 09 45Exploring elucidating and engineering complex flavonoid glycoside biosynthesisSandra Irmisch Leiden University The NetherlandsNot available on demand09 45 10 00Leveraging the benefits of genetic mapping within local populations more fully reveals the genetic basis of defensive metabolite diversityAndrew Gloss New York University USA10 00 10 30Coffee Break and Meet the speakers with Leandro Quadrana and Asaph Aharoni10 30 11 00Biosynthesis of quinolizidine alkaloids in lupinsFernando Geu Flores University of Copenhagen Denmark11 00 11 15A novel single cell metabolomics method for the study of plant natural products biosynthesisLorenzo Caputi Max Planck Institute for Chemical Ecology Germany11 15 11 45Translational plant natural product researchXiaoguang Lei Peking University ChinaNot available on demand11 45 12 00Esculetin is biosynthesized via novel O demethylation activity in Arabidopsis thalianaAlicja Dobek University of Gdansk Poland12 00 13 30Vegetarian lunch Meet the Editors13 30 16 30Session 3 Evolution of metabolism IIChaired by Sarah E O Connor Max Planck Institute for Chemical Ecology Germany13 30 14 00Identification and functional characterization of protein metabolite interactionsAleskandra Skirycz Michigan State University USA14 00 14 15Real time evolution of plant chemical defenses in natural communitiesShuqing Xu University of Mainz Germany14 15 14 30A bipartite biosynthetic gene cluster and convergent enzyme evolution in mint monoterpenoid metabolismBenjamin Lichman University of York UK14 30 15 00Coffee Break and Meet the speakers with Fernando Geu Flores Xiaoguang Lei Aleskandra Skirycz15 00 15 30Understanding plant resilience against climate change through the lens of a thermophilic plantSeung Yon Sue Rhee Michigan State University USA Remote talk Not available on demand15 30 15 45Convergent evolution of ipecac alkaloid biosynthesisMaite Colinas Max Planck Institute for Chemical Ecology Germany15 45 16 00Plant metabolic plasticity in response to various microbesJo lle Schl pfer Sasse Universit t Z rich Switzerland16 00 16 30Flash talks odd numbers 41 Himani Agrawal 47 Jiawen Chen 59 Justyna Lalak Kanczugowska 61 Ruoxi Lin 65 Nadja Nolte 69 Izabela Perkowska 71 Claude Becker 73 Vojtech Schmidt16 30 18 00Poster Session 1 odd numbers with beer and snacks18 00Free evening Day 3 Thursday 11 April 2024 TimeEurope BerlinSpeaker09 00 12 00Session 4 Biology of genomesChaired by Douglas Domingues University of S o Paulo Brazil09 00 09 30Epigenetic reprogramming in plant germlinesXiaoqi Feng Institute of Science and Technology Austria Austria09 30 09 45Glycosylation of the transcription factor WOX4 regulates radial growth and gene expression in ArabidopsisPascal Hunziker Centre of Organismal Studies COS Heidelberg University Germany09 45 10 00Changing the structure of plant genomes by CRISPR Cas mediated chromosome engineeringMichelle R nspies Karlsruhe Institute of Technology KIT Germany10 00 10 30Coffee Break and Meet the speakers with Xiaoqi Feng10 30 11 00Evolution of cell type specific specialized metabolismC Robin Buell University of Georgia USA11 00 11 15Induced genetic variation Precision breeding utilizing conventional breeding technologiesAgnieszka Nielsen Traitomic Carlsberg Group Denmark11 15 11 45Transcriptional regulation of photosynthesisAndrea Br utigam Bielefeld University GermanyNot available on demand11 45 12 00Unveiling the green code benchmarking gene prediction tools and analyzing factors shaping precise annotation in plant genomesQussai Abbas Technical University of Munich Germany12 00 13 30Lunch13 30 16 30Session 5 Plants in their environmentChaired by Anna Ihnatowicz University of Gdansk Poland13 30 14 00My model organism eats your model organism a Drosophila that attacks Arabidopsis leads to a plant size locusNoah Whiteman University of California Berkeley USA14 00 14 15Variance in drought tolerance in the European oak genotypes from German forestsTetyana Nosenko Helmholtz Zentrum M nchen Germany14 15 14 30Interspecies pathway engineering to investigate the immune function of Trp derived specialized metabolismGopal Singh Polish Academy of Sciences Poland14 30 15 00Coffee Break and Meet the speakers with C Robin Buell Andrea Br utigam Noah Whiteman Tonni Grube Andersen 15 00 15 30Cellular lockdowns plasmodesmal regulation of trade offs between growth and defence in plantsChristine Faulkner John Innes Centre UK15 30 15 45Structural features of receptor like proteins RLPs enable versatile immune recognitionAdam Steinbrenner University of Washington USA15 45 16 15Evolution sub functionalisation and regulation of biosynthetic gene clustersClaude Becker Ludwig Maximilians University of Munich Germany16 15 16 30Spatio temporal chemical modulation of root associated microbial communities in the Brassicaceae familyAndra Octavia Roman Max Planck for Plant Breeding Research Germany16 30 17 00Flash talks even numbers 42 Rachna Behl 48 Arpita Chowdhury 50 Douglas Domingues 62 Jian Feng Mao 72 Santiago Priego Cubero17 00 18 30Poster Session 2 even numbers with beer and snacks18 30 20 30Conference dinner20 30 23 00Conference party Day 4 Friday 12 April 2024 Time Europe Berlin Speaker09 00 11 45Session 6 Evolution of phenotypes Chaired by Claude Becker Ludwig Maximilians Universit t M nchen Germany 09 00 09 30Thoughts on the evolution of the sporophyteJohn Bowman Monash University Australia09 30 09 45Creating a genomic and molecular toolbox to assess whether gene duplication has allowed for higher morphological diversity in Begonia Lucy Turnbull University of Edinburgh Royal Botanical Gardens of Edinburgh UK09 45 10 00Comparative transcriptomic analysis of the fern group reveals the evolution of cell wall modulesMarek Mutwil Nanyang Technological University Singapore10 00 10 30Coffee Break and Meet the speakers with Christine Faulkner John Bowman Edwige Moyroud 10 30 10 45Stoma to stomach the evolutionary connection of guard cells and gland cells in cephalotus follicularisDorothea Graus University of W rzburg Germany10 45 11 00A single cell transcriptomic approach to decode the evolutionary innovation of stomatal form and function in a model grassLea Berg University of Bern SwitzerlandNot available on demand11 00 11 30All bullseyes great and small understanding the development and evolution of petal patterning in HibiscusEdwige Moyroud University of Cambridge UK11 30 11 45Closing Remarks and Poster Prize Announcements11 45Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Nathalie Sneider for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Monday 11 March 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 04 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergSteffi s Hostel HeidelbergHotel Bayrischer Hof Leonardo Hotel Heidelberg City CentreHotel Vier Jahreszeiten HeidelbergB B HotelHotel MonptiExzellenz HotelPremier Inn Heidelberg CityHotel Holl nder Hof Staycity Aparthotel Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Please find the bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event sponsor ABclonal Germany Media partners EMBO Journal an EMBO Press Journal FEBS Open Bio International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Barbara Ann Halkier, Sarah E. O’Connor, Detlef Weigel

8 April - 12 April 2024

Data-driven approaches to understanding dementia

Description This course provides individuals working in dementia research with the skills to access and analyse dementia data Participants will learn to apply bioinformatics methodologies combine different data types and utilise relevant dementia data resources enhancing their research capabilities in the field...

Juanita Riveros

8 April - 12 April 2024

scATAC-seq: attacking open chromatin in single cells

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview ATAC Seq stands for Assay of Transposase Accessible Chromatin and is a widespread method to profile open chromatin on a genome scale The goal of this introductory course is to teach the entire workflow of a single cell ATAC Seq experiment including library preparation sequencing data processing and downstream analysis by addressing a real biological question that will be answered at the end of the course We will start with the experimental single cell ATAC Seq protocol highlighting the critical steps potential pitfalls and the most up to date tweaks to improve the quality of the results After sequencing the samples we will go through the basic quality control and preprocessing steps using multiple analysis tools for next generation sequencing data Finally we will perform different types of analysis on the processed data including visualisation differential peak calling and differential transcription factor activity profiling to come to a biological conclusion In addition we will discuss recent advancements in technology development and algorithms for joint analysis of scRNA and scATAC seq data how to use these joint modalities to generate gene regulatory networks and give an outlook on future perspectives and applications including ways for multiplexing scRNA scATAC assays and high throughput cost effective options Audience This course is directed towards molecular biologists who want to perform scATAC Seq experiments and or analysis in their lab Learning outcomes After this course you should be able to Perform complete flow for single cell ATAC Seq experiments Process and quality control of single cell ATAC Seq data Visualise the data and call differences between samples Analyse and interpret the data using existing tools What past participants say about the course A very well tailored course with fantastic speakers who take you on an exciting journey from wet lab to data analysis Mahdi Adam Mickiewicz University Poland It was an intense but very informative and motivating week Both the theoretical and practical parts were perfectly organised Thank you for the price worthy experience Kristyna Zavacka Masaryk University Czech Republic Speakers Christian Arnold EMBL Heidelberg Germany Gwen Bauersachs EMBL Heidelberg Germany Vladimir Benes EMBL Heidelberg Germany Ivan Berest ETH Z rich Switzerland Annique Claringbould EMBL Heidelberg Germany Michael Dorrity EMBL Heidelberg Germany Charles Dussiau EMBL Heidelberg Germany Cyndie Forestier Element Biosciences France Juan Jauregui EMBL Heidelberg Germany Dirk J rgensen 10X Genomics Germany Maksim Kholmatov EMBL Heidelberg Germany Ulrike Litzenburger Nuvisan Innovation Campus Berlin Germany Sara Lobato Moreno EMBL Heidelberg Germany Kristy Ou EMBL Heidelberg Germany Hilal Ozgur EMBL Heidelberg Germany Karin Prummel EMBL Heidelberg Germany Nila Servaas EMBL Heidelberg Germany Evi Vlachou EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg Germany Judith Zaugg EMBL Heidelberg Germany Katharina Zirngibl Heidelberg University Germany Jan Provaznik EMBL Heidelberg Germany Scientific organisers Vladimir Benes EMBL Heidelberg Germany Ulrike Litzenburger Nuvisan Innovation Campus Berlin Germany Judith Zaugg EMBL Heidelberg Germany Course organisers Inna B sselmann Course and Conference Manager EMBL Heidelberg Germany Irena Provaznikova Scientifc Training Manager EMBL Heidelberg Germany Programme Are you on social media Post using EMBLATAC and don t forget to tag EMBLEvents Day 1 Monday 8 April 2024 TimeSpeakerLocation08 40Bus from ISG Hotel to EMBLISG Hotel entrance09 00 09 45Welcome introduction and safety briefingVladimir Benes EMBL Heidelberg GermanyUlrike Litzenburger Nuvisan Innovation Campus Berlin GermanyJudith Zaugg EMBL Heidelberg GermanyCourtyard Room A B09 45 10 45Participants flash talksCourtyard Room A B10 45 11 00Coffee break11 00 11 45Experimental practical Introduction and preparation to experimental practicalGwen Bauersachs EMBL Heidelberg GermanyUlrike Litzenburger Nuvisan Innovation Campus Berlin GermanyTraining Lab A B11 45 12 45LunchEMBL Canteen 12 45 14 45 Experimental practical Sample preparation and transpositionGwen Bauersachs EMBL Heidelberg GermanyJuan Jauregui EMBL Heidelberg GermanySara Lobato Moreno EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyKarin Prummel EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab A B14 45 17 30Experimental practical with flexible coffee break GEM formation and elongationGwen Bauersachs EMBL Heidelberg GermanyJuan Jauregui EMBL Heidelberg GermanySara Lobato Moreno EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyKarin Prummel EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab A B17 30 17 45Coffee break17 45 18 15Seminar Nuclei isolation Tips and Tricks Karin Prummel EMBL Heidelberg GermanyCourtyard Room A B18 15 19 00Lecture Single cells ATAC Seq introduction Ulrike Litzenburger Nuvisan Innovation Campus Berlin GermanyEMBL Canteen19 00 20 15DinnerEMBL Canteen 20 15Bus from EMBL to ISG Hotel Day 2 Tuesday 9 April 2024 TimeSpeakerLocation08 40 Bus from ISG Hotel to EMBLISG Hotel entrance09 00 12 00Experimental practical with flexible coffee break Breaking GEMs and library preparationGwen Bauersachs EMBL Heidelberg GermanyJuan Jauregui EMBL Heidelberg GermanySara Lobato Moreno EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyKarin Prummel EMBL Heidelberg GermanyDaphne Welter EMBL Heidelberg GermanyTraining Lab A B12 00 13 00LunchEMBL Canteen 13 00 13 10Results explanationUlrike Litzenburger Nuvisan Innovation Campus Berlin GermanyTraining Lab A B13 10 14 00 Lecture Cyndie Forestier Element Biosciences FranceCourtyard Room A B14 00 15 40 Bioanalyzer results explained Gwen Bauersachs EMBL Heidelberg GermanyKarin Prummel EMBL Heidelberg GermanyHilal Ozgur EMBL Heidelberg GermanyCourtyard Room A B15 00 15 40Coffee break and GeneCore tourGeneCore15 40 16 00Start of sequencing run16 00 16 30Coffee break and Q AFoyer16 30 19 30Students presentations pizzaCourtyard Room A B19 30Bus from EMBL to ISG HotelATC entrance Day 3 Wednesday 10 April 2024 TimeSpeakerLocation08 40Bus from ISG Hotel to EMBLISG Hotel entrance09 00 10 00Lecture Sample Preparation for scATAC Assay What are important factorsDirk J rgensen 10X Genomics GermanyCourtyard Room A B10 00 10 45Lecture A multimodal approach to identify molecular drivers of follicular lymphoma transformationKristy Ou EMBL Heidelberg GermanyCourtyard Room A B10 45 11 00Coffee break11 00 11 45Lecture Overview of computational methods for integrating scATAC Seq and scRNA seqJudith Zaugg EMBL Heidelberg GermanyCourtyard Room A B11 45 12 30Lecture sequencing technologiesVladimir Benes EMBL Heidelberg GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen 13 30 14 00Students presentations IICourtyard Room A B14 00 14 30Group photo and coffee break14 30 16 00Computational practical Introduction to Linux R and computational analysesChristian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyComputer Training Lab16 00 16 30Lecture AVITI data pre processing Jan Provaznik EMBL Heidelberg GermanyComputer Training Lab16 30 18 30Computational practical Start computational analysis overnightChristian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyComputer Training Lab18 30 19 30DinnerEMBL Canteen19 30 Bus from EMBL to ISG HotelATC entrance Day 4 Thursday 11 April 2024 TimeSpeakerLocation08 40Bus from ISG Hotel to EMBLISG Hotel entrance09 00 10 30 Computational practical with flexible coffee break Christian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyKristy Ou EMBL Heidelberg GermanyNila Servaas EMBL Heidelberg GermanyKatharina Zirngibl University Heidelberg GermanyCharles Dussiau EMBL Heidelberg GermanyEvi Vlachou EMBL Heidelberg GermanyComputer Training Lab10 30 12 30Computational practicalChristian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyKristy Ou EMBL Heidelberg GermanyNila Servaas EMBL Heidelberg GermanyKatharina Zirngibl University Heidelberg GermanyCharles Dussiau EMBL Heidelberg GermanyEvi Vlachou EMBL Heidelberg GermanyComputer Training Lab12 30 13 30LunchEMBL Canteen 13 30 14 00Lecture Overview of scATAC computational analysesIvan Berest ETH Z rich SwitzerlandComputer Training Lab14 00 16 00Computational practicalChristian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyKristy Ou EMBL Heidelberg GermanyNila Servaas EMBL Heidelberg GermanyKatharina Zirngibl University Heidelberg GermanyCharles Dussiau EMBL Heidelberg GermanyEvi Vlachou EMBL Heidelberg GermanyComputer Training Lab16 00 16 30Coffee break16 30 18 30Computational practicalChristian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyKristy Ou EMBL Heidelberg GermanyNila Servaas EMBL Heidelberg GermanyKatharina Zirngibl University Heidelberg GermanyCharles Dussiau EMBL Heidelberg GermanyEvi Vlachou EMBL Heidelberg GermanyComputer Training Lab18 40Bus from EMBL to downtownATC entrance19 30Course dinner downtown at Oskar restaurantRestaurant Day 5 Friday 12 April 2024 TimeSpeakerLocation08 40Bus from ISG Hotel to EMBLISG Hotel entrance09 00 09 30Lecture Applications of sc ATAC seq to understand zebra fish in developmentMike Dorrity EMBL Heidelberg GermanyComputer Training Lab09 30 12 00Computational practical with flexible coffee break Christian Arnold EMBL Heidelberg GermanyIvan Berest ETH Z rich SwitzerlandAnnique Claringbould EMBL Heidelberg GermanyMaksim Kholmatov EMBL Heidelberg GermanyKristy Ou EMBL Heidelberg GermanyNila Servaas EMBL Heidelberg GermanyKatharina Zirngibl University Heidelberg GermanyCharles Dussiau EMBL Heidelberg GermanyEvi Vlachou EMBL Heidelberg GermanyComputer Training Lab12 00 13 00 LunchEMBL Canteen 13 00 14 00Participants prepare for presentationsComputer Training Lab14 00 14 30Coffee break14 30 16 00Presentation of results by participantsComputer Training Lab16 00 16 30Wrap up end of the course and departureComputer Training Lab16 30Bus downtown to Heidelberg train stationATC entrance Practical information Registration fees and motivation letter The course is limited to 18 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 715PhD Student 715Industry 1225 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 5 nights 7 12 April 2024 at the ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code ATA24 01 by the deadline of 11 March 2024 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors course partner course sponsor Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Ulrike Litzenburger, Judith Zaugg

28 March 2024

Explore Human Pangenome Reference Consortium (HPRC) data in Ensembl

Description The Human Pangenome Reference Consortium HPRC aims to construct a comprehensive and representative human pangenome reference to better illustrate the genomic landscape of diverse human populations In this webinar we will guide you on how to access HPRC data via the Ensembl genome browser We will explore the available gene annotation and genetic variation data of the sequence assemblies produced by the project...

27 March 2024

The Pathogens Portal: A gateway to vast biomolecular data for pathogen research

Description The COVID 19 pandemic starkly illuminated the crucial role of open biodata in combating infectious diseases EMBL EBI recognising this significance swiftly launched the COVID 19 Data Portal a centralised repository for SARS CoV 2 related biomolecular data Building upon this success the Pathogens Portal emerges as the spiritual successor expanding its scope to encompass a broader spectrum of pathogens The Pathogens Portal serves as a comprehensive resource for researchers clinicians and policymakers seeking access to a wealth of biomolecular data related to a diverse range of pathogens It aims to facilitate rapid knowledge discovery accelerate disease prevention and treatment strategies and foster collaboration across the scientific community This webinar introduces the Pathogens Portal to users demonstrating the why and how it exists how we decide what pathogens are included as well as a tour of the features in the portal It will deepen participants understanding of how to use the portal and introduce features that are part of the broader platform such as the datahubs a system for sharing data in a controlled access environment You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below Introduction to the pathogens portalWhat data types are included in the portalPathogens portal tourSearching and browsing dataQ A...

20 March 2024

Microbial biodiversity at schools and its link with children’s health

Description There is a wealth of microbial diversity in the environment in soil on plants and in the atmosphere Urbanisation usually involves disturbance and sealing of soil along with a decrease and alteration of vegetation This process drastically reduces natural microbial sources such as soil and phyllosphere leaf surfaces which also contribute to enriching the atmosphere Nevertheless in an urban environment other microbial sources are more common such as wastewater treatment trash and human associated microbes Significant differences have been observed in the environmental microbial communities between urban and non urban environments Several hypotheses highlight the importance of contact with diverse natural microbial communities for human health especially for children In this webinar using a case study of the Belgian B SEBALL project we will illustrate how to investigate microbial biodiversity at school playgrounds and its potential contribution to different aspects of children s health This case study showcases the possibilities and limits of 16S rRNA amplicon sequencing in the context of the biodiversity hypothesis Does microbial diversity benefit human health The answer seems to be more nuanced than expected We will also demonstrate the power of adjusting and generating hypotheses based on field microbiome data You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionCharacteristics of urban environments associated with urban diseasesThe human microbiome and its importanceMicrobiomes connecting One healthThe biodiversity hypothesisInvestigating the biodiversity hypothesis in Belgian schoolsQ A...

19 March - 22 March 2024

Protein quality control for downstream processes

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Purified proteins are used in various types of scientific experiments and fields For example in structural biology insights into the functional mechanisms can be obtained by elucidating the 3D molecular structure of proteins and protein complexes using technologies such as X ray crystallography cryo EM and NMR In biochemistry and biophysics interactions with other proteins nucleic acids and small molecules can be studied by determining affinities and specificities Proteins can function as antigens to generate specific antibodies or as reagents in cell biology experiments Furthermore recombinant proteins can be used as tool molecules in genomics chemical biology and microscopy assays In order for these experiments to produce reliable and biologically relevant results they must be performed using high quality proteins that are active properly folded in the right oligomeric state and contain correctly inserted co factors Ensuring that these parameters are fulfilled requires quality control In this course we want to help the participants to become acquainted with the concept of protein quality control and provide them with an overview of the specific protein requirements for various downstream applications Different techniques that can be applied for this purpose will be introduced and participants will have the opportunity to get hands on experience with these technologies Audience This course is aimed at life science researchers of all levels who are using or plan to use purified proteins in their wet lab experiments but who do not necessarily have a strong background in protein production and characterisation methods We will focus on introducing protein quality control methodologies in order to improve the reliability and reproducibility of data obtained from experiments that make use of purified proteins After this course participants should be familiar with the biochemical and biophysical techniques that can be applied to ensure that they are working with high quality protein samples suitable for the planned downstream experiments Modules resources Basic information Protein expression and purification process Protein concentration Buffer conditions pH ionic strength buffer components Purity and intactness SDS PAGE right size no degradation UV VIS spectrum nucleic acid contaminations Mass spectrometry expected molecular weight and amino acid sequence Homogeneity polydispersity SEC SEC MALS oligomeric state no aggregates molar mass DLS presence of aggregates Mass photometry oligomeric state molar mass Flow Induced Dispersion Analysis presence of aggregates Folding state and conformational stability Circular dichroism secondary structure influence of buffer conditions and or ligands Nano DSF thermofluor optimal buffer conditions thermal stability Activity Enzymatic assays functionality Interaction studies ITC MST Flow Induced Dispersion Analysis affinity for binding partners Learning outcomes During the course specialists from both academia and industry will work closely together to introduce technologies frequently used in protein quality control Some of these methodologies can be utilised both to assess protein quality and as standalone biophysical characterisation techniques Our main goals are Teach the participants how to perform proper protein quality control checks Introduce the participants to various biophysical techniques used for protein characterization such as SEC MALS DLS SLS mass photometry nano DSF flow induced dispersion analysis and spectroscopy Show participants how to characterize protein interactions using ITC MST and flow induced dispersion analysis Where possible allow participants to apply these technologies onto their own protein samples in the practicals Overall increase the success rate reliability and reproducibility of downstream experiments in which purified proteins are used What past participants say about the course This advanced course was my first live experience at the EMBL and it was superb It was packed with great lectures state of the art technology fruitful discussions and beautiful people The course was also a great opportunity to meet new people and expand your network Highly recommend and I will definitely attend the next event Klemen Mezgec National Institute of Chemistry Ljubljana Slovenia Speakers Speakers trainers and staff Sebastian Eustermann EMBL Heidelberg Germany David Golonka Wyatt Technology Germany Felix Gloge Wyatt Technology Germany Janosch Hennig EMBL and University of Bayreuth Germany Marijke Jansma NanoTemper Technologies Germany Sebastian Joecks Refeyn UK Stephan Koetzner FidaBio Denmark Arpita Kundu NanoTemper Technologies Germany Karine Lapouge EMBL Heidelberg Germany Caroline Mas Biophysics Platform Insitut de Biologie Structurale Grenoble France Melanie McDowell Max Planck Institute of Biophysics Germany Stephen Maughan Refeyn UK Bertrand Raynal Institut Pasteur France Kim Remans EMBL Heidelberg Germany Mandy Rettel EMBL Heidelberg Germany Agatha Rosenthal Malvern Pananalytical UK Jan Schaeferkordt Refeyn UK Sascha Schifrin Wyatt Technology Germany Arthur Sedivy Protein Technologies Core Facility Vienna BioCenter Austria Peter Spies FidaBio Denmark Bernd Tartsch Malvern Pananalytical UK Scientific organisers Karine Lapouge EMBL Heidelberg Germany Kim Remans EMBL Heidelberg Germany Bertrand Raynal Institut Pasteur France Course organisers Maria Bacadare Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLProteinQC and don t forget to tag EMBLEvents Day 1 Tuesday 19 March 2024 Time Europe Berlin SpeakerLocation08 20 08 50Bus from Premier Inn Hotel to EMBLPremier Inn City Center Hotel bus stop09 00 09 45Welcome house notes course overviewKarine Lapouge EMBL Heidelberg GermanyKim Remans EMBL Heidelberg GermanyCourtyard Room A B09 45 10 00Tour de tableCourtyard Room A B10 00 11 00Flash talks 20 students 3 minutes eachCourtyard Room A B11 00 11 30Coffee breakCourtyard Room A B11 30 11 50FidaBio introductionStephan Koetzner FidaBio DenmarkPeter Spies FidaBio DenmarkCourtyard Room A B11 50 12 10Malvern introductionAgatha Rosenthal Malvern Pananalytical UKBernd Tartsch Malvern Pananalytical UKCourtyard Room A B12 10 12 30NanoTemper introductionMarijke Jansma NanoTemper Technologies GermanyArpita Kundu NanoTemper Technologies GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 13 50Refeyn introductionSebastian Joecks Refeyn UKJan Schaeferkordt Refeyn UKCourtyard Room A B13 50 14 10Wyatt introductionFelix Gloge Wyatt Technology GermanyDavid Golonka Wyatt Technology GermanySascha Schifrin Wyatt Technology GermanyCourtyard Room A B14 10 15 00Lecture 1 Assessing and improving protein sample qualityBetrand Raynal Institut Pasteur FranceCourtyard Room A B15 00 15 30Coffee breakCourtyard Room A B15 30 18 30Practical session 1All trainersTraining Lab A B18 30 20 00DinnerATC Rooftop Lounge20 00 20 30Bus from EMBL to Premier Inn HotelEMBL bus stop Day 2 Wednesday 20 March 2024 Time Europe Berlin SpeakerLocation08 20 08 50Bus from Premier Inn Hotel to EMBLPremier Inn City Center Hotel bus stop09 00 09 10Overview of the dayCourtyard Room A B09 10 10 00Lecture 2 An overview of protein expression and purification methods for obtaining high quality protein samplesKim Remans EMBL Heidelberg GermanyCourtyard Room A B10 00 10 30Coffee breakCourtyard Room A B10 30 11 20Lecture 3 Spectroscopy Methods for Protein Quality ControlArthur Sedivy Protein Technologies Core Facility Vienna BioCenter AustriaCourtyard Room A B11 20 12 10Lecture 4 Analytical Ultracentrifugation for samples characterization and quality controlCaroline Mas Biophysics Platform Insitut de Biologie Structurale Grenoble FranceCourtyard Room A B12 10 13 10LunchEMBL Canteen13 10 16 30Practical session 2All trainersTraining Lab A B16 30 17 00Coffee breakCourtyard Room A B17 00 17 50Preparation time for group presentationsCourtyard Room A B17 50 18 45Tour Protein Expression and Purification Core Facility PEPCF PEPCF EMBL18 45 19 15Bus departure to downtownEMBL bus stop19 30 00 00Downtown dinner Day 3 Thursday 21 March 2024 Time Europe Berlin SpeakerLocation08 20 08 50Bus from Premier Inn Hotel to EMBLPremier Inn City Center Hotel bus stop09 00 09 10Overview of the dayCourtyard Room A B09 10 12 10Practical session 3All trainersTraining Lab A B12 10 13 15LunchEMBL Canteen13 15 14 05Lecture 5 Protein quality control and cryoEM for membrane proteinsMelanie McDowell Max Planck Institute of Biophysics GermanyCourtyard Room A B14 05 15 00Lecture 6 Mass spectroscopy methods used in protein characterisation and quality controlMandy Rettel EMBL Heidelberg GermanyCourtyard Room A B15 00 15 30Coffee breakCourtyard Room A B15 30 18 30Practical session 4All trainersTraining Lab A B18 30 20 00DinnerCourtyard Room A B20 00 20 30Bus from EMBL to Premier Inn HotelEMBL bus stop Day 4 Friday 22 March 2024 Time Europe Berlin SpeakerLocation08 20 08 50Bus from Premier Inn Hotel to EMBLPremier Inn City Center Hotel bus stop09 00 09 10Overview of the dayCourtyard Room A B9 10 10 00Lecture 7 Cryo EMSebastian Eustermann EMBL Heidelberg GermanyCourtyard Room A B10 00 10 50Lecture 8 NMR as a tool for protein quality controlJanosch Hennig EMBL Heidelberg University of Bayreuth GermanyCourtyard Room A B10 50 11 15Coffee breakCourtyard Room A B11 15 12 15Discussion practical 1Courtyard Room A B12 15 13 15LunchEMBL Canteen13 15 14 15Discussion practical 2Courtyard Room A B14 15 15 15Discussion practical 3Courtyard Room A B15 15 16 15Discussion practical 4Courtyard Room A B16 15 16 30Feed back and closing remarksCourtyard Room A B Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 715PhD Student 715Industry 1225 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 4 nights 19 22 March 2024 at the Premier Inn Hotel City Centre Heidelberg Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course e g PQC24 01 by the deadline of 20 February 2024 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor more information about accommodation and travel please refer to the FAQ page On site information Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Karine Lapouge, Kim Remans, Bertrand Raynal

19 March - 21 March 2024

Metabarcoding and data sharing for environmental DNA

Description This course will demonstrate applying metabarcoding analysis to eDNA for assessing biodiversity Sequencing DNA barcodes from mixed sources of DNA is being increasingly used to survey biodiversity whether analysing dietary content from faecal derived DNA or monitoring aquatic species from water derived DNA This course will give an overview of metabarcoding with different barcoding genes to target particular taxa Using an example data set we will go from raw sequence data through to assigning taxonomy to the sequence variants and some examples of downstream community analysis Sessions will comprise presentations and self paced computer practicals guided by an online interactive book containing theory and practice code This virtual course will be delivered via live streamed talks on Zoom with support from instructors via Zoom and Slack during the timetabled sessions Computer practicals will run on a virtual training platform so attendees will not need access to a powerful computer or to install any software We are willing to make reasonable adjustments to facilitate learning where possible and will provide clear routes to enable anyone that requires this to discuss this with us ahead of the training...

Ajay Mishra

19 March - 22 March 2024

Biological oscillators: rhythms and synchronisation across scales

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia Kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Are you interested to discuss oscillatory phenomena and biological dynamical systems accross temporal and spatial scales At this symposium multiple disciplines will come together in order to discuss common themes linked to oscillations rhythms and synchronization in a broad range of contexts The 2024 edition of this established symposium will expand the discussion to the scale of ecological oscillations and willl also highlight the interplay between internal and environmental rhythms This meeting provides a unique platform to bring together a community working at the interface between quantitative biology complex oscillatory systems modelling and theory As with the editions in 2015 2018 and 2022 this meeting aims to serve as a bridge between experimentalists and theorists and to reveal common challenges and approaches that can be shared across fields Session Topics Oscillation mechanisms across different scales from circadian clock to embryonic oscillators to biochemical metabolic oscillations Oscillation function across scale and context Synchronisation of coupled oscillators Ecological rhythms and oscillations Mathematical modelling and computational approaches Imaging approaches to study oscillatory dynamics Pre symposium workshop Oscillator Theory for Biologists workshop optional Registration and details of this will be announced nearer the date What past participants say about the Symposium As a first time attendant at EMBL conference on Biological oscillations I found the event exceptionally excellent As an interdisciplinary researcher I learned about so many diverse topics and I was even offered a possible postdoc position Hamed Yeganegi Chair of Zoology TUM Munich and GSN LMU Munich Germany It was an exciting conference where new research unexpected results and profound analysis were presented In addition very bold hypotheses were discussed As a result I have new ideas for further research and possible collaborations Nancy Papalopulu F M I Basel Switzerland Speakers Speakers W Tecumseh Fitch University of Vienna Austria Alan Hastings University of California Davis USA Jae Kyoung Kim Institute for Basic Science IBS South Korea Aneta Koseska Max Planck Institue for Neurobiology Behaviour Germany Luis Larrondo Pontificia Universidad Catolica de Chile Chile Andrew Liebhold US Forest Service USA Andrew Charles Oates EPFL cole Polytechnique F d rale de Lausanne Switzerland Carrie Partch University of California Santa Cruz USA Filipa Rijo Ferreira University of California Berkeley USA Maria Robles Ludwig Maximilian University of Munich Germany Akiko Satake Kyushu University Japan Fran ois Schweisguth Institut Pasteur France Jun Yan Chinese Academy of Sciences China Scientific Organisers Alexander Aulehla EMBL Heidelberg Germany Alan Hastings University of California Davis USA Hanspeter Herzel ITB Humboldt University Berlin Germany Carrie Partch University of California Santa Cruz USA Conference organiser Chris Stocks Course and Conference Team Lead EMBL Heidelberg Germany Programme Are you on social media Post using EESBioOsc and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 19 March 2024 Time Europe Berlin Speaker12 30 13 45Registration and light refreshments13 45 14 00Opening remarks14 00 18 45Session 1Session Chair Hanspeter Herzel14 00 14 30Opening talk Synchrony in ecology why and howAlan Hastings University of California Davis USA14 30 15 00Oscillatory transients in natural systemsAneta Koseska Max Planck Institute for Neurobiology Behaviour Germany15 00 15 15Metachronal waves in the ciliary band of Platynereis dumerilii larvaeRebecca Poon University of Exeter UK15 15 15 45Coffee break and meet the speakersonsite participants to move to Large Operon 15 45 16 45Lecture Oscillator Theory for BiologistsHanspeter Herzel ITB Humboldt University GermanyVenue Large Operon16 45 17 00Break to prepare Tutorial 17 00 18 00Oscillator Theory 101 Hands on workshop on Biology and TimeMarta del Olmo Institute for Theoretical Biology BerlinZsofia Bujtar Max Delbr ck Center BerlinSaskia Grabe Institute for Theoretical Biology BerlinVenue Large Operon18 00 18 15Break and reconvene in the Auditorium18 15 18 45Circadian rhythms in hosts malaria parasites and their vectorsFilipa Rijo Ferreira University of California USA18 45 20 30Dinner in canteen20 30 22 00After dinner drinks and networking20 00Conference shuttle bus to all stops downtown including ISG21 00Conference shuttle bus to all stops downtown including ISG22 00Conference shuttle bus to all stops downtown including ISG Day 2 Wednesday 20 March 2024 Time Europe Berlin Speaker09 30 12 15Session 2Session Chair Aneta Koseska09 30 10 00Mastering noise in rhythm generation strategies for utilization and avoidanceJae Kyoung Kim Korea Advanced Institute of Science and Technology Republic of Korea10 00 10 15Notch signaling dynamics during small intestine homeostasisSonja Weterings Hubrecht Institute The Netherlands10 15 10 30Delta Cells Modulate Pancreatic Islets Beta Cell Calcium Wave Origin FormationYi Yu Peking University China10 30 11 00Coffee break and meet the speakers11 00 11 15Controlling condensates and through protein oscillationsMathias Luidor Heltberg University of Copenhagen Denmark11 15 11 45These go to eleven pushing period range in eukaryotic clocks a perspective on ultradian as well as fast circadian rhythmsLuis Larrondo P Universidad Catolica de Chile Millennium Institute for Integrative Biology iBio Chile11 45 12 15Organization of cellular network of circadian oscillators in the nervous systemJun Yan Center for Excellence in Brain Science and Intelligence Technology Chinese Acadamy of Sciences China12 15 13 45Lunch and meet the editors 13 45 16 30Session 3Session Chair Ueli Schibler13 45 14 15Periodic oscillations and synchronization of forest insect outbreaks across large spatial scalesAndrew Liebhold USDA Forest Service Northern Research Station USA14 15 14 30Molecular cooperation but functional antagonism how NF B activation perturbs p53 dynamics impairing DNA damage repair process Emanuele Colombo IRCCS Ospedale San Raffaele Italy14 30 14 45Distinct transcriptional oscillators in the circadian neuronal network preferentially synchronize with each otherDeniz Top University of Alberta Canada14 45 15 15Coffee break and meet the speakers15 15 15 30Early birds and slow worms probing links between conserved biological timing mechanisms in nematodes and mammals Rebecca Spangler University of California Santa Cruz United States of America15 30 15 45Uncovering a signaling role of metabolism in mammalian embryos using entrainment based dynamical systems approachHidenobu Miyazawa EMBL Heidelberg Germany15 45 16 00Emergent behavioural complexity in a ciliated microorganismAlexander Boggon University of Exeter UK16 00 16 30Morning larks and night owls shed light on human circadian timekeepingCarrie Partch University of California USA Virtual Speaker 16 30 17 00Flash talks 35 Bitsch Marion 37 Cebri n Lacasa Daniel 39 Combres Lea 41 Montagnac Guillaume 43 Denis Christian 49 Hawley Joshua 53 Kudo Shuichi 59 Naven Mark 63 Pietsch Julian 65 Pei Duanqing 67 Rowntree Andrew 69 Schreiber Igor 73 Stengl Monika 77 Valim Henrique 81 Zajac Olivier17 00 19 00Poster Session 1 odd numbers View poster listing here19 00 20 30Dinner in EMBL Canteen20 30 22 00After dinner drinks20 00Conference shuttle bus to all stops downtown including ISG21 00Conference shuttle bus to all stops downtown including ISG22 00Conference shuttle bus to all stops downtown including ISG Day 3 Thursday 21 March 2024 Time Europe Berlin Speaker09 30 12 30Session 4 Session Chair Alexander Auhlela09 30 10 00On clocks and timers in developmentAndrew Charles Oates EPFL Switzerland10 00 10 15Interrelation of circalunar circadian and photoperiodic time keeping in the marine midge ClunioJule Neumann Max Planck Institute for Evolutionary Biology Germany10 15 10 30A parsimonious mechanism to generate rhythmic gene expression with wide phase dispersionHelge Grosshans Friedrich Miescher Institute for Biomedical Research Switzerland10 30 11 00Coffee break and meet the speakers11 00 11 15Ghost cycles in biological systemsDaniel Koch Max Planck Institute for Neurobiology of Behavior Germany11 15 11 45Spatiotemporal dynamics of the mammalian circadian clock transcriptional active complex at the chromatinMaria Robles Ludwig Maximilians Universit t M nchen GermanyNot available on demand11 45 12 15Self organized patterning in the Drosophila eyeFran ois Schweisguth Institut Pasteur FranceNot available on demand12 15 12 30RBBP5 is an epigenetic regulator of mammalian 12h oscillator and stress responses Bokai Zhu University of Pittsburgh USA12 30 14 00Lunch14 00 16 30Group Activity Hike16 30 17 00Coffee break and meet the speakers17 00 17 30Flash talks 32 Abenza Juan F 34 Avello Paula 44 el Azhar Yasmine 50 Jadhav Dinesh 52 Zambrano Samuel 54 Mishra Nikhil 66 Gelens Lendert 70 Sellier Prono Marie 72 Nunley Hayden 76 Trummel Tabea 78 Weir Kurt 82 Zhu Ruimin17 30 19 30Poster session 2 even numbers View poster listing here19 30 21 00Conference dinner21 00 23 30Conference party with DJ21 30Conference shuttle bus to all stops downtown including ISG22 30Conference shuttle bus to all stops downtown including ISG23 30Conference shuttle bus to all stops downtown including ISG Day 4 Friday 22 March 2024 Time Europe Berlin Speaker09 30 12 15Session 5Session Chair Alan Hastings09 30 09 45Unlocking the rhythm Deciphering the role of rhythmic stability for circadian dynamics through single cell analysis and mathematical modelingMarta Del Olmo Institute for Theoretical Biology Humboldt Universit t zu Berlin and Charit Universit tsmedizin Berlin Berlin09 45 10 00HES1 oscillations offer a new perspective on re emergence from cellular dormancy in breast cancerOliver Cottrell University of Manchester UK10 00 10 30Synchrony from genes to ecosystemsAkiko Satake Kyushu University Japan10 30 11 00Coffee break and meet the speakers11 00 11 15Control of segmentation timing in the zebrafish notochordAdhyapok Priyom Duke University USA11 15 11 30Theoretical analysis of body temperature fluctuation during hibernationShingo Gibo RIKEN Japan11 30 11 45Cytoplasmic oscillations and cytoskeletal dynamics collectively control the cell cycle periodMartina Boiardi KU Leven Belgium11 45 12 15Human rhythmic synchronization in music dance and languageW Tecumseh Fitch University of Vienna Austria12 15 12 30Closing remarks and poster prize announcements12 30 12 45Packed lunch and departure12 45Airport bus to Frankfurt airport13 00Conference shuttle bus to all stops downtown including ISG Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editor 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Christopher Stocks for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 20 February 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 02 to confirm the exact price of the room Hotel AnlageISG Hotel Steffi s Hostel HeidelbergHotel Bayrischer Hof Hotel MonptiStaycity Aparthotel HeidelbergB B HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel ibis HeidelbergPremier Inn Heidelberg City Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Here is the conference shuttle bus timetable The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event sponsor Bruker goodBot Event supporter Media partners EMBO Reports an EMBO Press journal FEBS Letters International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media Kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Alexander Aulehla, Alan Hastings, Hanspeter Herzel, Carrie Partch

18 March - 22 March 2024

Livestock genomics

Description This hands on virtual course will introduce participants to methods and approaches for analysing genomic data from common livestock species including cattle pig chicken and sheep During the course participants will learn about the use of sequencing methods in the field of livestock genomics resequencing genomes locating variant data annotating genomes and carrying out GWAS approaches The course will also cover the use of public EMBL EBI resources such as Ensembl EVA and ENA to progress in your research as well as to submit and share your discoveries with the community and will present relevant use cases in the field The course will enable you to harness the wealth of publicly available farmed animal datasets held in EMBL EBI public archives and utilise our free services and tools to for example identify genetic variants associated with disease identify genetic markers associated with desirable breeding traits or use Ensembl Variant Effect Predictor VEP tool to predict the functional impact of genetic variants EMBL EBI is committed to support the livestock research community and industry to improve animal health and welfare increase productivity and reduce environmental impact Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available during the course hours maximum 09 00 18 30 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Sophie Spencer

13 March 2024

Strain-resolved approaches for human microbiome studies

Description In the last few years the human microbiome has received great attention by the community due to its fundamental role in health and disease Advancements in the field have also been possible due to technological improvements in shotgun metagenomics including the development and application of computational approaches This webinar will introduce metagenomics for characterisation of the human microbiome with focus on computational tools to achieve strain level resolution This will comprise pipelines for generation of profiles as well as extraction of draft genomes It will also present some recent analyses aiming at conducting large scale scenario investigations including the use of machine learning approaches and the integration of human microbiomes with other sources You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionHow can we study the microbiome The shotgun metagenomics workflowMicrobiome and colorectal cancer CRC Strain resolved metagenomicsToward full mappability of the human microbiomeThe curated Food Metagenomic Data resourceQ A...

12 March - 15 March 2024

AI and biology

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kitDB train strike information Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Artificial intelligence AI is transforming virtually all areas of science and the life sciences are no exception AI based methods are pushing the limits of what is possible in experimental design data analysis simulation and modelling The aim of this symposium is to catalyse synergistic interactions between AI researchers in different subfields of biology by exploring shared theoretical approaches cross domain experiments and data integration as well as shared topics in dissemination of tools and collaboration with experimental labs Furthermore we will look into the future and discuss how the concerted actions of AI and life science communities can enable both fields to exploit the full potential of the ongoing data deluge and find new application areas ripe for disruption by AI AI based analytics is subject to active research in at least three major application areas sequencing imaging and structural biology While all three domains are experiencing very fast growth the development of AI based analysis is largely happening independently The aim of our symposium is to bring these communities together to discuss topics of mutual interest to make progress including on the theoretical methodological side and on the more strategic issues of identifying the next areas of high potential Session topics Challenging the state of the art Cross domain cross modality learning Explainable AI and its role in science From algorithms to biology Connections to the wider AI field Generative modeling from drug design to synthetic images Speakers Mohammed AlQuraishi Columbia University USA Ewan Birney EMBL EBI Hinxton UK Michael Bronstein University of Oxford UK Arne Elofsson SciLifeLab Sweden Trey Ideker University of California San diego USA Florian Jug Human Technopole Italy Samuel Kaski Aalto University and University of Helsinki Finland Jennifer Listgarten University of California Berkeley USA Julia Mahamid EMBL Heidelberg Germany Lena Meier Hein German Cancer Research Center Germany Alex Rives New York University USA Fabian Theis Helmholtz Munich Germany Caroline Uhler Broad Institute of MIT and Harvard USA Mihaela van der Schaar University of Cambridge UK Jong Chul Ye Korea Advanced Institute of Science and Technology KAIST Korea Ellen Zhong Princeton University USA Scientific organisers Mohammed AlQuraishi Columbia University USA Wolfgang Huber EMBL Heidelberg Germany Anna Kreshuk EMBL Heidelberg Germany Emma Lundberg Stanford University USA Oliver Stegle EMBL Heidelberg and German Cancer Research Center Conference organiser Charlotte Courtney EMBL Heidelberg Germany Programme Are you on social media Post using EESAIBio and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 12 March 2024 Timings Europe CET Speaker12 00 13 30Registration and light refreshments13 45 17 15Session 1 Challenging the state of the artChairs Anna Kreshuk and Mohammed AlQuraishi13 30 13 45Opening remarks13 45 14 15Question everything A critical reflection of medical imaging AILena Maier Hein German Cancer Research Center Germany14 15 14 30GROVER Building a language model of the human genomeMelissa Sanabria Dresden University of Technology Germany14 30 14 45Deep mutational scanning of entire human protein interaction domain familiesGuillaume Diss Virtual speaker Friedrich Miescher Institute for Biomedical Research Germany14 45 15 15Coffee break and meet the speakers of day one Lena Maier Hein Michael Bronstein Mihaela van der Schaar15 15 15 45To be presented on siteMichael Bronstein University of Oxford UK15 45 16 00Protein engineering using transformer based energy landscape approximationEvgenii Lobzaev University of Edinburgh UK16 00 16 15AI based biomarker identification and profiling in heterogeneous prostate tumorsKathleen Marchal Ghent University IMEC Belgium16 15 16 45Beyond Causality Discovering and Analyzing the Governing Equations of MedicineMihaela van der Schaar University of Cambridge UK16 45 17 15Flash talks for poster session 1 Anna Poetsch 41 Bernard Ciraulo 55 Ava Khamseh 87 Christian Kolter 93 Dan Liu 103 Niklas Schmacke 143 Ron Schwessinger 145 Konstantina Tzavella 157 17 15 18 45Poster session 1 odd numbers 18 45 20 15Dinner in canteen20 15 22 00After dinner drinks in the ATC Foyer20 15Conference shuttle bus to all stops downtown including ISG21 00Conference shuttle bus to all stops downtown including ISG22 00Conference shuttle bus to all stops downtown including ISG Day 2 Wednesday 13 March 2024 Timings Europe CET Speaker08 45 9 00Arrival and coffee09 00 12 00Session 2 cross domain cross modality learningChairs Jong Chul Ye and Uwe Ohler09 00 09 30Learning a foundational representation of the cellular nicheFabian Theis Helmholtz Munich Germany09 30 09 45SpaceTree Deciphering Tumor Microenvironments by joint modeling of cell states and genotype phenotype relationships in spatial omics dataOlga Lazareva EMBL DKFZ Germany09 45 10 00Accurately predicting single cell drug responses of progressed melanoma patientsGabriele Gut University Hospital Z rich Switzerland10 00 10 30Coffee break and meet the EditorsGemma K Alderton Deputy Editor Insights ScienceGeorge Caputa Senior Editor Nature ResearchRituparna Chakrabarti Senior Scientific Editor iScienceQian Cheng Associate Editor Computational Biology Nature CommunicationsMike Fletcher Senior Editor Nature GeneticsSara Osman Associate Editor Nature Structural Molecular BiologyMaria Polychronidou Senior Editor Molecular Systems BiologyArunima Singh Senior Editor Nature Methods10 30 11 00Machine learning for reconstructing protein structure and dynamics from cryo EM imagesEllen Zhong Princeton University USA11 00 11 15AI based protein stability prediction from sequences and structures and its application to the engineering of plastic degrading enzymesAnia Di Pede Mattatelli Institute of Marine Sciences ICM CSIC Barcelona Spain11 15 11 30Regression on latent spaces predicts multi condition single cell gene expressionConstantin Ahlmann Eltze EMBL Heidelberg Germany11 30 12 00To be presented on siteSami Kaski Aalto University and University of Helsinki Finland12 00 13 30Lunch13 30 16 00Session 3 Explainable AI and its role in scienceChairs Leopold Parts and Alex Rives13 30 14 00Causal Representation Learning and Optimal Design of InterventionsCaroline Uhler Broad Institute of MIT and Harvard USA14 00 14 15Learning and visualizing the morphological differences between synapses of different typesDiane Adjavon HHMI Janelia USA14 15 14 30MoCHI mechanistic AI models from deep mutational scanning dataAndre Faure ALLOX Spain14 30 15 00Coffee break and meet the speakers of day two Fabian Theis Ellen Zhong Sami Kaski Caroline Uhler Trey Ideker15 00 15 30Assembling a Digital Tumor CellTrey Ideker University of California San Diego USA15 30 15 45Variational autoencoder for design of synthetic viral vector serotypesMichael Garton Virtual speaker University of Toronto Canada15 45 16 00Comprehensive characterization of human druggable pockets through novel binding site descriptors built upon inverse dockingArnau Comajuncosa Creus IRB Barcelona Spain16 00 Free evening downtown Heidelberg16 15Conference shuttle bus to all stops downtown including ISG Day 3 Thursday 14 March 2024 Timings Europe CET Speaker08 45 09 00Arrival and coffee09 00 12 15Session 4 from algorithms to biologyChairs Ellen Zhong and Florian Jug09 00 09 30The convergence of genomics imaging and AI for understanding lifeEwan Birney EMBL EBI Hinxton Cambridge UK09 30 09 45Modeling regulatory networks with single cell expression dataUwe Ohler Max Delbr ck Center for Molecular Medicine and Humboldt University of Berlin Germany09 45 10 00Pre trained molecular representations can aid antimicrobial discoveryRoberto Olayo Institute for Statistics LMU M nchen Germany10 00 10 30Coffee break 10 30 11 00Enabling discovery by in cell structural biology challenges in cryo electron tomography data mining and integrationJulia Mahamid EMBL Heidelberg GermanyNot available on demand11 00 11 15Integration of variant annotations using deep set networks boosts rare variant association geneticsEva Holtkamp Technical University of Munich Germany11 15 11 30Exploiting time to phenotype cell morphologyJulian Pietsch Max Planck Institute for Terrestrial Microbiology Germany11 30 12 15Panel discussion From algorithms to biologyModerator Emma Lundberg12 15 13 45Lunch13 45 16 45Session 5 connections to the wider AI fieldChairs Oliver Stegle and Samuel Kaski13 45 14 15Towards a Complete Structural Map of the Human Proteome Using AlphaFoldArne Elofsson SciLifeLab Sweden14 15 14 30Towards transformer based tracking in live cell microscopyBenjamin Galusser EPFL Switzerland14 30 14 45Can AI predict how human cells interpret dinosaur DNA Leopold Parts The Wellcome Trust Sanger Institute UK14 45 15 15Coffee break and meet the speakers of day three Ewan Birney Julia Mahamid Arne Elofsson Alex Rives Jong Chul Ye15 15 15 45Language Modeling at the Scale of EvolutionAlex Rives EvolutionaryScale USANot available on demand15 45 16 00BioCypher and BioChatter open frameworks for AI ready biomedical knowledge graphs and their integration with current Large Language ModelsSebastian Lobentanzer Heidelberg University and Heidelberg University Hospital Germany16 00 16 30Enlarging the Capability of Diffusion Models for Inverse Problems in ImagingJong Chul Ye Korea Advanced Institute of Science and Technology KAIST Korea16 30 16 45PeTriBERT Augmenting BERT with tridimensional encoding for inverse protein folding and designBaldwin Dumortier CNRS France16 45 17 15Flash talks for poster session 2 Cedric Allier 42 Noah Bruderer 52 Adele de Hoffer 58 Albert Dominguez Mantes 62 Lucas Farndale 64 Lucien Hinderling 76 Grzegorz Kudla 96 Xiaomei Li 100 Paulyna Maga a 106 Abdelrahman Mahmoud 108 Roman Bushuiev 138 Yuxin Shen 148 17 15 18 45Poster session 2 even numbers 18 45 21 00Conference dinner21 00 00 00Party with The Chaotics band20 30Conference shuttle bus to all stops downtown including ISG21 30Conference shuttle bus to all stops downtown including ISG22 30Conference shuttle bus to all stops downtown including ISG23 59Conference shuttle bus to all stops downtown including ISG Day 4 Friday 15 March 2024 Timings Europe CET Speaker08 45 09 00Arrival and coffee09 00 13 00Session 6 generative modeling from drug design to synthetic imagesChairs Wolfgang Huber and Arne Eloffson09 00 09 30From Content Aware Denoising to Semantic Unmixing of Microscopy Data how AI is and will transform scientific image data analysis in the life sciencesFlorian Jug Human Technopole Italy09 30 09 45Controllable generative modelling lessons from protein designKieran Didi University of Cambridge UK09 45 10 15Some thoughts on machine learning based protein engineeringJennifer Listgarten University of California Berkeley USA10 15 10 45Coffee Break and Meet the speakers of day four Florian Jug Jennifer Listgarten Mohammed AlQuraishi10 45 11 45Panel discussion Industry vs AcademiaModerators Wolfgang Huber and Oliver Stegle11 45 12 00Seedling a scoring and generation framework for protein ligand co foldingWilliam McCorkindale Charm Therapeutics UK12 00 12 30To be presented on siteMohammed AlQuraishi Columbia University USA12 30 12 45Efficient and accurate sequence generation with small scale protein language modelsYaiza Serrano Nostrum Biodiscovery Spain12 45 13 00Closing Remarks and Poster Prize Announcements13 00Packed lunch and departure13 20Conference shuttle bus to all stops downtown including ISG13 20Conference shuttle bus to Frankfurt Am Main International Airport Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks live streamed and on demand and the facility to submit questions On site Academia 725On site PhD Student 625On site Industry 925On site Journal Editors 300Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Charlotte Courtney for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Monday 12th February 2024 in some cases at special rates Please email the hotel directly quoting the booking code EES24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Here is the conference shuttle bus timetable The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsor Novigenix Event supporters Media partners Disease Models Mechanisms The Company of Biologists Journal FEBS Letters International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Molecular Systems Biology an EMBO Press Journal Open Biology a Royal Society journal PLOS Biology a PLOS journal Royal Society of Chemistry Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 Leaderboard 728 90 DB train strike information Deutsche Bahn DB the national rail provider has announced a last minute strike affecting all rail travel across Germany on Tuesday 12 March Further details can be found here on the DB website There is a version in English here Currently DB state that long distance intercity trains regional and local trains will be severely disrupted DB rail tickets booked on or before 10 March for travel on Tuesday 12 March can now be used flexibly and are valid on any train either today Monday 11 March long distance trains only or after 12 March We realise this could impact your journey to the EMBO EMBL Symposium AI and biology The following information is to assist you in checking and adjusting travel plans to reach Heidelberg Arriving to Heidelberg Tuesday 12 March 2024 By train DB says that long distance regional and local S Bahn train services in Germany will be severely disrupted on Tuesday Only very few services will run The timetable will be updated regularly on the DB website and app If your accommodation arrangements can be changed consider making use of the flexible ticket validity announced by DB to travel to Heidelberg tonight before the strike Alternatively you could look into bus route alternatives driving or car sharing The strike affects only travel on the first day of the four day symposium Of course you will still be able to join if you arrive on day 2 as a last resort By air from Frankfurt Main Airport EMBL will provide 3 buses free of charge departing from Terminal 1 Bus stop P36 bus parking lot Frankfurt Main Airport at 9 00 1 bus and 11 30 2 buses Places are limited on a first come first served basis If you arrive before this time please wait at the airport until the buses depart These buses will take you directly to EMBL Heidelberg The buses Hoffman Reisen company will be on the P36 bus lot and have a sign displaying EMBL SHUTTLE in the front window By car car sharing Car parking is available at EMBL Heidelberg We recommend connecting with other participants in advance is the Discussion area in the virtual platform for the conference Joining instructions for the virtual conference platform have been sent to you separately Important Please check with your hotel if parking is available and if a reservation is required FAQS 1 Is the conference still running as scheduled YES 2 I cannot travel to EMBL Heidelberg to attend the conference onsite due to the strike and none of the above options work for me All is not lost as a second best you can attend the conference as a virtual participant using the details previously sent The strike only affects travel on the first day of the four day symposium 3 Can I get a refund if I cannot attend the conference Unfortunately not However you can still enjoy the conference as a virtual participant using the details previously sent 4 Will EMBL provide any other buses outside of what has been arranged during the strikes No However you can also make alternative transport arrangements by clicking on the useful links websites below 5 Do I need to reserve a seat on the EMBL airport bus on Tuesday 12 March No Seats are on a first come first served basis However we have planned that capacity will not be exceeded 6 Where do I find the buses at the Frankfurt airport From Terminal 1 you can reach the long distance bus parking lot P36 via Arrival C Then keep right The long distance bus parking lot is signposted 7 Does the strike affect local buses and trams in Heidelberg No Public buses and trams will continue to operate as planned 8 Do I need to pay for the EMBL buses from Frankfurt Main to Heidelberg on Tuesday 12 March No EMBL are providing this free of charge 9 How will I know which is the correct bus from the airport to Heidelberg EMBL on Tuesday 12 March At Frankfurt Main airport buses will depart from Terminal 1 Bus stop P36 parking lot Buses Hoffman Reisen company will have a sign displaying EMBL SHUTTLE in the front window of the bus 10 Will the conference shuttle buses from Heidelberg hotels to EMBL still run Yes we are providing transport service as usual at specific times Information can be found here 11 What if I miss the EMBL airport bus Alternative transport is available Please see useful websites below 12 Will the trains run on Friday check out day of the conference Yes The strike is expected to end at 2am on Wednesday 13 March We will keep participants updated if this changes You can also follow on the DB website here 13 Can I get a taxi from the airport to Heidelberg Yes official taxis which run on a meter basis are available outside the airports but this is an expensive option at around 200 Euros for a normal passenger car from Frankfurt airport for example Alternatively Personal Transfers Heidelberg are an option if you want to consider pre booking a private individual or group car transfer from the airport 14 Where can I connect with other participants to discuss transport arrangements An option for connecting with other participants in advance is the virtual platform for the conference under discussion menu Joining instructions for the virtual conference platform have been sent to you separately 15 If arriving directly to EMBL can I bring my luggage Yes There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Useful websites information DB Deutsche Bahn website containing useful strike and travel information TRN Airport Transfer airport transfer provider Taxi Weinmann taxi company close to Heidelberg offering airport transfers Flixbus bus transfers across Germany Busradar long distance buses EMBL information for participants travelling to EMBL Heidelberg Taxis from the airports official taxis which run on a meter basis are available outside the airports but this is an expensive option at around 200 Euros for a normal passenger car from Frankfurt airport for example We hope you find the above helpful However if you still have a question that is not answered above please email us with any queries at events embl de Please note Information is correct at the time of issue 11 March 2024 15 00 and is subject to change...

Mohammed AlQuraishi, Wolfgang Huber, Anna Kreshuk, Emma Lundberg, Oliver Stegle

11 March - 15 March 2024

Mathematics of life: modelling molecular mechanisms

Description This course will provide participants with an introduction and hands on training on modelling approaches tools and resources used in systems biology as well as touch on network analysis Computer models are increasingly used to understand the essential processes of biology Researchers in academic institutions as well as the pharmaceutical industry use mathematical models to generate hypotheses on how complex biomolecular systems work Modelling of biochemical pathways deregulated in disease conditions can offer mechanistic insights into the pathology help to elucidate mechanisms behind drug action and predict the dose required for treatment thus facilitating fundamental research and drug discovery This course will provide a helpful brief introduction to key modelling concepts and hands on training to use popular tools and resources used in this scientific field Virtual courseParticipants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 00 17 30 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Juanita Riveros

6 March 2024

Bioinformatic approaches to understand the role of the human microbiome in health and disease

Description The human microbiome represents a diverse community of microbes with important roles for the maintenance of human health The wealth of metagenomics data currently available has brought about a new era of research for the human microbiome field The ability to reconstruct high quality microbial genomes purely from metagenomic sequencing data has unlocked our ability to study the hidden microbial universe living alongside us Given there are thousands of human associated bacterial species that cannot yet be experimentally characterised there is a need to develop and apply bioinformatics methods to better understand their role in health and disease This webinar will provide an overview of current metagenomic approaches to study the human microbiome and introduce several statistical methods that can be used to link its composition and function to different human phenotypes and populations You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionThe microbiome in human biologyWhat can metagenomics tell us What is genome assembly Evaluating genome MAG qualityLinking microbiome composition to phenotypeAdditional resourcesQ A...

4 March - 8 March 2024

Introduction to multi-omics data integration and visualisation

Description With the increase in the volume of data across the whole spectrum of biology more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences This may also include public domain data which can provide added value to data derived through researcher s own work and inform experimental design This introductory course will highlight the challenges that researchers face in integrating multi omics data sets using biological examples The course will focus on the use of public data resources and open access tools for enabling integrated working with an emphasis on data visualisation This course will not include systems biology modelling or machine learning A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI data resource and research teams This allows people to explore the bioinformatics tools and resources introduced in the course and to apply these to a set problem providing hands on experience of relevance to their own research The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of integrating data You may refer to the previous group projects that were organised for this course in March 2023...

Meredith Willmott

4 March - 8 March 2024

Gene expression at spatial resolution

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This interactive course will introduce participants to a new generation of a spatially resolved transcriptomics assay provided by 10x Genomics Objectives The Visium Cytassist Spatial Gene Expression Solution uses probes targeting the whole transcriptome for intact tissue sections in morphological context offering a previously inaccessible view of tissue biology These two complementary methods to study tissue come together on Visium Cytassist Spatial Gene Expression slides Through practical work in the lab and theoretical sessions the participants will learn the entire workflow of sample preparation of fresh frozen tissue samples fixation and sequencing library preparation Utilising the 10x Genomics Loupe Browser pipeline the participants will also have hands on training in spatial transcriptomics data analysis Audience This is an interdisciplinary course designed for molecular biologists as well as researchers more familiar with morphology analysis by brightfield and fluorescence microscopy who are seeking to introduce the 10x Genomics Visium Cytassist Spatial Gene Expression application into their labs research Modules Resources Overview of 10x Genomics Visium Cytassist Spatial Gene Expression technology Focusing on fresh frozen samples with Hematoxylin and Eosin H E staining Alternative staining by Immunofluorescence and usage of FFPE samples as starting material Pre recorded application lectures on Spatial Transcriptomics Theoretical aspects of cryosectioning and brightfield and fluorescence microscopy Visium Spatial Gene Expression data analysis using Loupe Browser license free 1 on 1 Project Consultation with application specialist optional service offered at the discretion of the individual participant Learning Outcomes After this course you will be able to Appreciate the importance of spatially resolved transcriptomics data Realise the significance of properly prepared tissue sections by cryosectioning Understand the requirements for brightfield and fluorescent tissue slide imaging Analyse and interpret data output using Loupe Browser What past participants say about the course Gene expression at spatial resolution workshop was amazing Thanks to the organizing team and all the trainers I could practice each step from sectioning to data analysis Also meeting with other participants with varying backgrounds and the expert lecturers was a great opportunity Mustafa Beter University of Eastern Finland Finland This course provided a week of hands on practical training on 10X Visium complemented by scientific talks and discussions Not only was I introduced to the workflow of the technique but I also received advice tailored to my specific research question and tissue type Rounded off with a thorough step by step guide on data analysis I now feel confident to start my experiments soon Lisa Mayrginther Maastricht University Finland Speakers Speakers trainers Ahmad Al Alwash EMBL Heidelberg Germany Monika Dabrowska 10x Genomics United Kingdom Linda Decker EMBL Heidelberg Germany Anna Klemm SciLifeLab and Uppsala University Sweden Mireia Osuna Lopez EMBL Heidelberg Germany Kristy Ou EMBL Heidelberg Germany Valeriy Pak EMBL Heidelberg Germany Idoia Quintana Urzainqui EMBL Heidelberg Germany Sinem Saka EMBL Heidelberg Germany Oliver Stegle EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg Germany Scientific organisers Vladimir Benes EMBL Heidelberg Germany Dirk J rgensen 10x Genomics Germany Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Sophie Dutzi Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Programme Are you on social media Post using EMBLSpatialOmics and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 4 March 2024 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel08 45 09 00RegistrationCourtyard Room A B09 00 09 30Welcome and house notes and course overviewCourtyard Room A B09 30 10 30Flash talk sessionCourtyard Room A B10 30 11 00Coffee BreakCourtyard Room A B11 00 12 00Lecture 1 Introduction to the Visium Spatial Gene Expression WorkflowDirk J rgensen 10x Genomics GermanyCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 15 30Practical session 1 Sample fixation staining and probe hybridizationAhmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining Lab A B15 30 16 00Coffee breakCourtyard Room A B16 00 18 00CryoStat demo session ALMF tour and imagingMonika Dabrowska 10x Genomics UKAhmad Al Alwash EMBL Heidelberg GermanyLinda Decker EMBL Heidelberg GermanyDB unit ALMF18 00 19 00Lecture 2 Imaging good practicesAhmad Al Alwash EMBL Heidelberg GermanyCourtyard Room A B19 00 20 00DinnerEMBL Canteen20 00Departure to HotelATC Entrance Day 2 Tuesday 5 March 2024 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 05Overview of the dayTraining Lab B09 05 10 05Practical session 2 Post Hybridzation Wash Probe Ligation Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining Lab B10 05 11 05Lecture 3 A DNA toolbox for spatial biologySinem Saka EMBL Heidelberg GermanyCourtyard Room A B11 05 12 05Practical session 3 Post ligation wash Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining Lab B12 05 13 05LunchEMBL Canteen13 05 17 05Practical session 4 Cytassist sessionTraining Lab B17 05 17 35Practical session 5 Probe extension Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining lab B17 35 18 35Lecture 4 Rubbish In Equals Rubbish Out The Importance of Sample QualityMonika Dabrowska 10x Genomics UKCourtyard Room A B18 35 19 35DinnerEMBL Canteen19 35Departure to HotelATC Entrance Day 3 Wednesday 6 March 2024 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 05Overview of the dayTraining lab B09 05 10 35Practical session 6 Probe elution and pre amplification Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining lab B10 35 10 50Coffee breakCourtyard Room A B10 50 11 50Practical session 7 SPRI beads clean up Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining lab B11 50 12 50Lunch and course group photoEMBL Canteen12 50 13 50Lecture 5 Studying the shark embryo to understand the cellular origin and evolution of the vertebrate brainIdoia Quintana Urzainqui EMBL Heidelberg GermanyCourtyard Room A B13 50 14 05Coffee breakCourtyard Room A B14 05 15 05Practical session 8 qPCR cycle number determination Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining lab B15 05 16 05Lecture 6 Title to be confirmedOliver Stegle EMBL Heidelberg GermanyCourtyard Room A B16 05Free evening16 05Departure to HotelIn front of ATC entrance16 25Bus to Neckarm nzplatzBus stop in front of ISG Hotel Day 4 Thursday 7 March 2024 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 20Practical Lecture 7 qPCR results explained Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyCourtyard Room A B09 20 10 00Practical session 9 Index PCR Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining Lab B10 00 10 30Coffee breakCourtyard Room A B10 30 11 30Practical session 10 Final clean up and QC Ahmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyTraining Lab B11 45 12 30LunchEMBL Canteen12 30 13 30Lecture 8 NGS an end point or a new beginning Vladimir Benes EMBL Heidelberg GermanyCourtyard Room A B13 30 13 50Practical Lecture 9 Bioanalyzer results explainedAhmad Al Alwash EMBL Heidelberg GermanyMonika Dabrowska 10x Genomics UKDirk J rgensen 10x Genomics GermanyFabio Marsoner 10x Genomics The NetherlandsMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyCourtyard Room A B13 50 15 50CryoStat demo session ALMF tour and imagingMonika Dabrowska 10x Genomics UKAhmad Al Alwash EMBL Heidelberg GermanyLinda Decker EMBL Heidelberg GermanyDB unit ALMF15 50 16 05Coffee breakCourtyard Room A B16 05 17 30Practical lecture and demo 10 Loop Browser and Space rangerDirk J rgensen 10x Genomics GermanyCourtyard Room A B17 30 18 00Departure to Hotel and DowntownIn front of ATC entrance18 00 19 30Free Time in the City Centre19 30 22 00Course dinner downtown Day 5 Friday 8 March 2024 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 10 30Practical session 11 Data analysis Ahmad Al Alwash EMBL Heidelberg Germany Kristy Ou EMBL Heidelberg GermanyValeriy Pak EMBL Heidelberg GermanyComputer Training Lab10 30 11 00Coffee breakComputer Training Lab11 00 12 00Practical session 12 Data analysis Ahmad Al Alwash EMBL Heidelberg Germany Kristy Ou EMBL Heidelberg GermanyValeriy Pak EMBL Heidelberg GermanyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 00Lecture 11 Evaluating Spatial Omics DataAnna Klemm SciLifeLab and Uppsala University SwedenCourtyard Room A B14 00 14 15Coffee breakComputer Training Lab14 15 14 45Course wrap upCourtyard Room A B14 45Departure ATC entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Academia 715PhD Student 715Industry 1225 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights 3 8 March 2024 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code SPA24 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Course Sponsor Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Dirk Jürgensen, Elisabeth Zielonka

29 February 2024

UniProt for proteomics scientists

Description UniProt is a comprehensive expert led publicly available database of protein sequence function and variation information This webinar will give a brief introduction to the UniProt website and then highlight resources available that proteomics scientists or users with large protein datasets may find useful in analysing their data This will encompass our proteomes service how to convert and retrieve ID mappings how to carry out a peptide search and how to visualise new large scale proteomics derived PTM data The webinar will then go on to introduce the UniProt Proteins API which allows researchers to access and download UniProt data alongside large scale genomic proteomics and variation data without needing prior in depth knowledge of programmatic languages Data is available for download and querying in a range of formats including XML FASTA and PEFF The API multi query search functions will be demonstrated and useful features such as searching the database by peptide finding proteomic evidence of post translational modifications and accessing a protein entry to find its peptides will be explained The UniProt Proteins API is available at www ebi ac uk proteins api doc...

28 February 2024

Exploring metagenomes to assess microbiomes across the globe

Description A metagenome is a sequencing sample of a bulk microbial community providing a genetic snapshot of the entire microbiome sampled Metagenomics offers a comprehensive genetic overview of microbial communities without the limitations of culture based methods The introduction of the shotgun method of metagenomics has added the ability to quantify the phylogenetic and functional roles of microbes without primer bias As sequencing becomes more affordable shotgun metagenomics is becoming an increasingly popular method for assessing microbiomes This webinar will offer a brief introduction to metagenomics and discuss various concepts and methods used in modern metagenomics Specifically we will explore topics such as using microbial composition as an indicator of ecosystem state using functional genes as biosensors and the insights that can be gleaned from genomic structure You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionTowards a planetary microbiomeWhat is a metagenome Scientific concepts and toolsMetagenome assembled genome MAG Metagenomics datasetsUseful toolsQ A...

27 February - 1 March 2024

Integrative analysis of multi-omics data

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Biological and biomedical research is increasingly driven by assays that measure multiple omics data types multi omics at single cell resolution and or with spatial resolution transcriptome proteome genomic variants epigenetic marks metabolome functional assays imaging Joint mathematical computational modeling mechanistic and integrated statistical analysis of such data is an urgent need one of the major analytical challenges scientists face today How to discover the important underlying patterns categories or trends and to arrive at statistically robust conclusions using explainable models of reasoning The course s core objective is to convey conceptual and mathematical foundations that underpin existing and emerging integrative multimodal data strategies and practical trade offs between various methods It will give participants an overview of the state of the art methods In practical sessions using real world examples participants will gain familiarity with software implementations practical aspects of quality assessment of inputs outputs and pitfalls method performance assessments tuning and model fit interpretation and relevant open science practices The course will cover methods such as multi table ordination and dimensionality reduction including the popular Multi Omics Factor Analysis MOFA method developed by the organizers Audience This course is aimed at PhD students and post docs in computational biology aiming to improve their skills in multi omics data integration methodologies Experience with R and or Python and willingness to work with both is a prerequisite for this course Modules Multi table integration Motivation concepts and theory Multi omics case studies and single cell multi omics spatial omics Data management and open science related topics in multi modal data integration Visualization interactive data analysis Learning outcomes The course will provide researchers with an overview and the theoretical foundations of state of the art methods for multi modal integration with a focus on omics data In practical sessions on relevant real world examples from single cell and bulk multi omics studies participants will gain familiarity with software implementations and learn about practical aspects including quality assessment of inputs and outputs method performance assessment choice of tuning parameters interpretation of the model fit and potential pitfalls What past participants say about the course An absolutely fantastic course I was introduced to new techniques I can apply to my data and to people with similar projects and challenges There is a free and friendly atmosphere all throughout the course which encourages discussion and further understanding of the techniques you apply Talks are given by experts in the techniques and the practical aspects of the course are great to apply the theory with experts nearby to help I would recommend this course to everyone with an interest in multi omic integration Annabel May MRC LMB Cambridge UK An amazing week filled with exchange of challenges and ideas Learned a lot of tips and tricks and got to know an inspiring group of people Thank you EMBL Sivarajan Karunanithi Institute for Molecular Biology gGmbH Mainz Germany This course has a recommendation rate of 100 by previous attendees Speakers Speakers trainers and staff Constantin Ahlmann Eltze EMBL Heidelberg Germany Ricard Argelaguet ALTOS Labs UK Jana Braunger Heidelberg University Germany Florian Buettner Goethe University Frankfurt German Cancer Research Center DKFZ Germany Erin Chung EMBL Heidelberg Germany Shila Ghazanfar University of Sydney Australia Elyas Heidari German Cancer Research Center DKFZ Germany Susan Holmes Stanford University USA virtual Sarah Kaspar EMBL Heidelberg Germany Olga Lazareva EMBL Heidelberg German Cancer Research Center DKFZ Germany Kim Anh L Cao The University of Melbourne Australia virtual Junyan Lu University Hospital Heidelberg Germany Matthias Meyer Bender EMBL Heidelberg Germany Julia Philipp EMBL Heidelberg Germany Martin Rohbeck EMBL Heidelberg German Cancer Research Center DKFZ Harald V hringer EMBL Heidelberg Dietrich Group Germany Florin Cornelius Walter EMBL Heidelberg German Cancer Research Center DKFZ Germany Judith Zaugg EMBL Heidelberg Germany Scientific organisers Wolfgang Huber EMBL Heidelberg Germany Oliver Stegle German Cancer Research Center DKFZ Germany Britta Velten Heidelberg University Germany Course organisers Luana Ribeiro Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Scientific Training Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOMultiOmics and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change On boarding session Tuesday 13 February 2024 Time Europe Berlin SpeakersLocation08 00 09 00On boarding session and Q A regarding software installationVirtual Day 1 Tuesday 27 February 2024 Time Europe Berlin SpeakersLocation08 40 09 00Bus from ISG Hotel to EMBLHotel Entrance08 50 09 15RegistrationCourtyard Room09 15 09 45Welcome and safety instructionsWolfgang Huber EMBL Heidelberg GermanyCourtyard Room09 45 10 00Course OverviewBritta Velten Heidelberg University GermanyWolfgang Huber EMBL Heidelberg GermanyOliver Stegle DKFZ GermanyCourtyard Room10 00 10 45Networking Ice breaking activityEMBL Scientific Training TeamCourtyard Room10 45 11 45Lecture Probabilistic factor models for integration of multi omic data MOFA Britta Velten Heidelberg University GermanyCourtyard Room11 45 12 15Coffee BreakCourtyard Room12 15 12 45Discussion Open science and responsible conduct of research in data sciences Wolfgang Huber EMBL Heidelberg GermanyOliver Stegle DKFZ GermanyCourtyard Room12 45 13 45Lunch BreakCanteen13 45 15 15Pratical 1 Multi modal bulk assay data and application of MOFAJunyan Lu University Hospital Heidelberg GermanyJana Braunger Heidelberg University GermanyMartin Rohbeck DKFZ GermanyFlorin Cornelius Walter EMBL Heidelberg DKFZ GermanyMatthias Meyer Bender EMBL Heidelberg GermanyHarald V hringer EMBL Heidelberg Dietrich Group GermanyCourtyard Room15 15 15 45Coffee BreakCourtyard Room15 45 17 15Pratical 1 Multi modal bulk assay data and application of MOFA continued Junyan Lu University Hospital Heidelberg GermanyJana Braunger Heidelberg University GermanyMartin Rohbeck DKFZ GermanyFlorin Cornelius Walter EMBL Heidelberg DKFZ GermanyMatthias Meyer Bender EMBL Heidelberg GermanyHarald V hringer EMBL Heidelberg Dietrich Group GermanyCourtyard Room17 15 18 15Lecture Multi table methods statistical theory andpractical implementation issues Susan Holmes Stanford University USA Virtual Courtyard Room18 15 20 30Participants Presentations Networking Courtyard Room20 30 20 45Bus from EMBL to ISG HotelEMBL Bus Stop Day 2 Wednesday 28 February 2024 Time Europe Berlin SpeakersLocation08 40 09 00Bus from ISG Hotel to EMBLHotel Entrance09 00 09 15Overview of the dayCourtyard Room09 15 10 15Lecture Multi omics analysis using gene regulatory networks for understanding complex traits and disease Judith Zaugg EMBL Heidelberg GermanyCourtyard Room10 15 10 30Coffee BreakCourtyard Room10 30 11 30Participant Presentations NetwokingCourtyard Room11 30 12 30Lecture Principles of single cell data integration Constantin Ahlmann Eltze EMBL Heidelberg Germany Ricard Argelaguet ALTOS Labs UKCourtyard Room12 30 13 30Lunch BreakCanteen13 30 13 45Group Photo13 45 15 15Pratical 2 Integrative analysis of multi modal single cell dataRicard Argelaguet ALTOS Labs UKJana Braunger Heidelberg University GermanyConstantin Ahlmann Eltze EMBL Heidelberg GermanyFlorin Cornelius Walter EMBL Heidelberg DKFZ GermanyErin Chung EMBL Heidelberg GermanyJulia Philipp EMBL Heidelberg GermanyCourtyard Room15 15 16 15Lecture Computational approaches for single cell mosaic data integrationShila Ghazanfar University of Sydney AustraliaCourtyard Room16 15 16 45Coffee BreakCourtyard Room16 45 18 45Pratical 2 Integrative analysis of multi modal single cell data continued Ricard Argelaguet ALTOS Labs UKJana Braunger Heidelberg University GermanyConstantin Ahlmann Eltze EMBL Heidelberg GermanyFlorin Cornelius Walter EMBL Heidelberg DKFZ GermanyErin Chung EMBL Heidelberg GermanyJulia Philipp EMBL Heidelberg GermanyCourtyard Room18 45 19 00Bus from EMBL to ISG HotelEMBL Bus Stop19 00 20 00Course DinnerISG Hotel20 00 21 00Round table discussion Problems and challenges in data integration including RCR principles ISG Hotel Day 3 Thursday 29 February 2024 Time Europe Berlin SpeakersLocation08 40 09 00Bus from ISG Hotel to EMBLHotel Entrance09 00 09 15Overview of the dayCourtyard Room09 15 10 15Lecture Multivariate Data Integration Methods andApplications with R and the mixOmics Package Kim Anh L Cao The University of Melbourne Australia Virtual Courtyard Room10 15 11 15Pratical 3 Integrative analysis of droplet basedsingle cell and spatial dataHarald V hringer EMBL Heidelberg Dietrich Group GermanyJulia Philipp EMBL Heidelberg GermanyShila Ghazanfar University of Sydney AustraliaOlga Lazareva DKFZ GermanyElyas Heidari DKFZ GermanySarah Kaspar EMBL Heidelberg GermanyCourtyard Room11 15 11 30Coffee BreakCourtyard Room11 30 12 30Pratical 3 Integrative analysis of droplet basedsingle cell and spatial data continued Harald V hringer EMBL Heidelberg Dietrich Group GermanyJulia Philipp EMBL Heidelberg GermanyShila Ghazanfar University of Sydney AustraliaOlga Lazareva DKFZ GermanyElyas Heidari DKFZ GermanySarah Kaspar EMBL Heidelberg GermanyCourtyard Room12 30 13 30Lunch BreakCanteen13 30 14 30Pratical 3 Integrative analysis of droplet basedsingle cell and spatial data continued Harald V hringer EMBL Heidelberg Dietrich Group GermanyJulia Philipp EMBL Heidelberg GermanyShila Ghazanfar University of Sydney AustraliaOlga Lazareva DKFZ GermanyElyas Heidari DKFZ GermanySarah Kaspar EMBL Heidelberg GermanyCourtyard Room14 30 15 00Coffee BreakCourtyard Room15 00 16 00Lecture Multi omics for precision oncologyJunyan Lu University Hospital Heidelberg GermanyCourtyard Room16 00 17 00Bus from EMBL to Heidelberg DowntownATC Entrance17 00 18 30Guided Tour of HeidelbergNeckarm nzplatz18 30 19 30Free Time in Old Town Heidelberg19 30 22 00 Downtown DinnerVetter s Alt Heidelberger Brauhaus Day 4 Friday 1 March 2024 Time Europe Berlin SpeakersLocation08 40 09 00Bus from ISG Hotel to EMBLHotel Entrance09 00 09 15Overview of the dayCourtyard Room09 15 10 15Lecture Encoding domain knowledge in multiviewlatent variable modelsFlorian Buettner Goethe University Frankfurt German Cancer Research Center DKFZ GermanyCourtyard Room10 15 11 00Discussion in small groups Time for participants to prepare presentationsCourtyard Room11 00 11 15Coffee BreakCourtyard Room11 15 12 00Discussion in small groups Time for participants to prepare presentationsCourtyard Room12 00 13 00Lunch BreakCanteen13 00 14 30Presentations DiscussionCourtyard Room14 30 14 45Coffee BreakCourtyard Room14 45 16 00Presentations DiscussionCourtyard Room16 00 16 15Feedback and closing remarksCourtyard RoomBus to ISG Hotel Heidelberg Train Station and City CenterEMBL Bus Stop Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 250PhD Student 250Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel EMBO Courses with TWIN ROOM COST paid by EMBL but SINGLE ROOM UPGRADE to be paid for by participants Accommodation in twin rooms including breakfast is included in the registration fee Accommodation has been booked for you at the ISG Hotel for the default dates of 26 February to 1 March 4 nights In case you would like to have a single room please let the hotel know and please note that you will be required to pay an additional cost of 32 per night availability of single rooms may be limited This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical 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Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Wolfgang Huber, Oliver Stegle, Britta Velten

20 February - 23 February 2024

The new cardiobiology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPre conference workshop Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The cardiovascular system is a multicellular and disseminated organ consisting of the heart a network of vessels and circulating blood thereby forming an intricately interdependent system whose dysfunction is the leading cause of human mortality Despite translational progress with impactful new interventional and pharmacological therapies cardiovascular dysfunction continues to plague mankind The current therapeutic approaches are either organ centric or tackle the consequences of end stage cardiovascular disease CVD New basic research approaches are focused on a deeper understanding of the causes and early development of CVD to identify mechanisms close to the root of the disease providing the promise to prevent halt and reverse the disease process In parallel new tissue engineering and mechanobiology approaches are revolutionizing cardiovascular discovery research and disease modeling by more closely mimicking the human situation However these are largely separated research communities with yet little crosstalk or exchange between the two This new EMBO Workshop aims to transform the established organ centric view on single cardiovascular organs into a systems biomedicine approach by tearing down the walls between disciplines and moving on to discussion of the cardiovascular system with an inter trans and cross disciplinary approach Session topics Where developmental biology meets cardiovascular engineering Where engineering meets cardiovascular regeneration Where cardiomyocyte biology meets immunology Where cardiomyocyte biology meets vascular biology Where cardiovascular biology meets mechanobiology Molecular circuits of heart disease Speakers Keynote speakers Christine Mummery Leiden University Medical Center The Netherlands Eric N Olson Southwestern Medical Center at Dallas USA Speakers Federica Accornero Brown University USA Pilar Alcaide Tufts University School of Medicine USA Hellmut Augustin Heidelberg University DKFZ Heidelberg Germany Alessandro Bertero University of Turin Italy Jennifer Davis University of Washington Seattle USA Gergana Dobreva Heidelberg University Germany Daniela Duarte Campos Heidelberg University Germany Holger Gerhardt Max Delbr ck Center Germany Kristina Haase EMBL Barcelona Spain Stephan Huveneers Amsterdam UMC The Netherlands Jose E Krieger University of Sao Paulo Medical School Brazil Timothy A McKinsey University of Colorado Anschutz Medical Campus USA Sasha Mendjan Institute of Molecular Biotechnology Vienna Austria Sara Nunes Vasconcelos Toronto General Hospital Research Institute Canada Enzo Porrello Murdoch Children s Research Institute Melbourne Australia Cecilia Sahlgren bo Akademi University and Eindhoven University of Technology Finland Lars Steinmetz EMBL Heidelberg Germany Eva van Rooij Hubrecht Institute The Netherlands Ryuji Yokokawa Kyoto University Japan Scientific organisers Pilar Alcaide Tufts University School of Medicine USA Johannes Backs Heidelberg University Germany Kristina Haase EMBL Barcelona Spain Enzo Porrello Murdoch Children s Research Institute Melbourne Australia Conference organiser Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBOCardioBiology and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 20 February 2024 Time Europe Berlin Session11 15 13 15Registration and light refreshments 11 45 12 45Industry workshop Suction assisted Imaging Window for Stabilized Intravital Imaging of Lung and Heart in a Live Animal by IVIM Technology registration required 13 15 13 30Opening remarks13 30 14 30Keynote Cardiovascular diseases and drugs where are we with hiPSC models Christine Mummery Leiden University Medical Center The Netherlands14 30 17 00Session 1 Where developmental biology meets cardiovascular engineering Chair Johannes Backs 14 30 15 00Genome editing to understand and engineer heart developmentAlessandro Bertero University of Turin Italy15 00 15 15A modified mRNA encoding Myc and Cyclin T1 improves cardiac function after myocardial injury in the mouseCatherine Wilson University of Cambridge United Kingdom15 15 15 45Coffee break and meet the speakers15 45 16 00Scaffold moulding for a heterotypic mini heartJuan Antonio Guadix Dominguez University of M laga Spain16 00 16 30Genetic and epigenetic regulation of cardiovascular development and diseaseGergana Dobreva Heidelberg University GermanyNot available on demand16 30 16 45Modeling diastolic dysfunction in a human heart on a chip platformOmar Mourad University of Toronto Canada16 45 17 00Epicardioids as a novel tool to study human heart development and diseaseTatjana Dorn Klinikum Rechts der Isar Technical University of Munich Germany17 00 17 30Cardioids unravel human heart development and diseaseSasha Mendjan Institute of Molecular Biotechnology Vienna Austria17 30 18 30Speed networking18 30 20 00Dinner in Canteen20 00 21 30After dinner drinks ATC Foyer Day 2 Wednesday 21 February 2024 Time Europe Berlin Session09 00 12 00Session 2 Where engineering meets cardiovascular regeneration Chair Jennifer Davis 09 00 09 30Vascularization strategies for cardiac regenerationSara Nunes Vasconcelos Toronto General Hospital Research Institute Canada09 30 10 00Targeting arrhythmia in hiPSC CMs and fibrosis in cardiac tissue cultureJos E Krieger University of Sao Paulo Medical School Brazil10 00 10 15Species matched cell therapy augments primary remuscularization to regenerate the chronically infarcted heartLay Ping Ong University of Cambridge United KingdomNot available on demand10 15 10 30NAD controls circadian rhythmicity during cardiac agingPieterjan Dierickx Max Planck Institute for Heart and Lung Research Germany10 30 11 00Coffee break and meet the speakers11 00 11 30Bioprinting cardiac tissue in vitro and in vivo Where are we at Daniela Duarte Campos Heidelberg University Germany11 30 12 00Maturing the heart implications for disease modelling drug discovery regenerative medicineEnzo Porrello Murdoch Children s Research Institute Melbourne AustraliaNot available on demand12 00 13 30Lunch12 40 13 30Meet the editorsModerator Pilar AlcaideEditors Yevgeniya Nusinovich Science Lise Roth EMBO Molecular Medicine 13 30 16 00Session 3 Where cardiomyocyte biology meets immunology Chair Kristina Haase 13 30 14 00Genetic engineering for cardiac fibrosisJennifer Davis University of Washington Seattle US14 00 14 15Characterization of aging associated immune alterations in post myocardial infarction mouse modelsDiyaa Ashour Universit tsklinikum W rzburg Germany14 15 14 30The PD 1 PD L1 pathway maintains an immunosuppressive environment essential for neonatal heart regenerationNing Liu UT Southwestern Medical Center USA14 30 15 00Adaptive immunity in heart diseasePilar Alcaide Tufts University School of Medicine Boston USA15 00 15 30Coffee break and meet the speakers15 30 15 45Mitochondrial GRK2 dependent regulation of myocardial cellular and transcriptional composition after ischemic injurySamuel Slone Duke University USA15 45 16 00Border zone cardiomyocytes and macrophages contribute to ECM remodeling to promote cardiomyocyte invasion during cardiac regenerationArica Beisaw Heidelberg University Hospital German Center for Cardiovascular Research DZHK Heidelberg Mannheim Germany16 00 16 30Epigenetic therapies for diastolic dysfunctionTimothy McKinsey University of Colorado Anschutz Medical Campus USANot available on demand16 30 17 00Flash talks17 00 18 30Poster Session 1 odd numbers with beer and snacks18 30 20 00Dinner in Canteen20 00 22 00Pub Quiz Day 3 Thursday 22 February 2024 Time Europe Berlin Session09 00 11 30Session 4 Where cardiomyocyte biology meets vascular biology Chair Pilar Alcaide 09 00 09 30Mechanisms and cellular heterogeneity in coronary vessel formationHolger Gerhardt Max Delbr ck Center Germany09 30 09 45Uncoupling hypertension from cardiac remodelingAnna Kaganovsky Technion Israel09 45 10 00NNT is required for heart failure with preserved ejection fractionMark Emile Pepin Brigham and Women s Hospital Harvard Medical School USA10 00 10 30Advancing tissue specific vascularized in vitro models a snapshot on human cardiac microvasculatureKristina Haase EMBL Barcelona SpainNot available on demand10 30 11 00Coffee break and meet the speakers11 00 11 15Endothelial inactivation of Sox9 protects from aging induced cardiac fibrosis and heart failure Felix Trogisch European Center for Angioscience Heidelberg University GermanyNot available on demand11 15 11 30Egr1 is a master regulator of regenerative senescence and cardiac repairLingling Zhang Weizmann Institute of Science Israel11 30 12 00Vascular control of short and long distance communicationHellmut Augustin Heidelberg University DKFZ Heidelberg GermanyNot available on demand12 00 13 30Vegetarian lunch12 40 13 30Closing the gap between academia and industryModerator Timothy McKinseyPanel members Ann Kristin M ller Bert Klebl Giulia Borghetti Eric N Olson Eva van Rooij Pablo Hofbauer13 30 16 30Session 5 Where cardiovascular biology meets mechanobiology Chair Enzo Porrello 13 30 14 00Jagged1 as an endothelial cell mechanoreceptorCecilia Sahlgren bo Akademi University and Eindhoven University of Technology Finland14 00 14 15Cardiac fibroblasts play an important role in the development of Marfan related cardiomyopathyJeffrey Aalders Ghent University Belgium14 15 14 30The Melusin cardioprotective chaperone tunes lipid metabolism to promote cardiac resilience to stressGiulia Savor University of Torino Italy14 30 15 00Endothelial mechanotransduction in vascular development and diseaseStephan Huveneers Amsterdam UMC The Netherlands15 00 15 15Regulation of ventricular contractility driven atrial ballooning by the alpha actinin family member ACTN4Dylan Burnette Vanderbilt University USA15 15 15 30Hydroxytyrosol Shielding vascular grafts against intimal hyperplasiaNadiah Sulaiman Universiti Kebangsaan Malaysia Malaysia15 30 16 00Coffee break and meet the speakers16 00 16 30Perfusable on chip vascular network for mechanobiology and developmental biologyRyuji Yokokowa Kyoto University Japan16 30 17 00Flash talks17 00 18 30Poster Session 2 even numbers with beer and snacks18 30 19 00Networking pre dinner drinks19 00 21 00Conference dinner21 00 00 30Party ATC Foyer Day 4 Friday 23 February 2024 Time Europe Berlin Session09 00 13 00Session 6 Molecular circuits of heart disease Chair Norbert Frey 09 00 09 30New concepts to treat arrhythmogenic cardiomyopathyEva van Rooij Hubrecht Institute The NetherlandsNot available on demand09 30 10 00Epitrancriptomic targets in heart diseaseFederica Accornero Brown University USANot available on demand10 00 10 15Cardiac sympathetic neuropathology supports the multicellularity of Arrhythmogenic CardiomyopathyInduja Perumal Vanaja University of Padua ItalyNot available on demand10 15 10 30Elucidating the molecular mechanisms and cellular specificity of HDAC inhibitor efficacy in diastolic dysfunctionJoshua Travers University of Colorado Anschutz Medical Campus USA10 30 10 45Re evaluating the fetal gene program at single cell resolution in dilated cardiomyopathy DCM Neda Rahmani Mehdiabadi Murdoch Children s Research Institute Australia10 45 11 15Coffee break and meet the speakers11 15 11 45Regulation of splicing in cardiomyopathiesLars Steinmetz EMBL Heidelberg Germany11 45 12 45Keynote Toward the genetic correction of heart and muscle diseaseEric N Olson UT Southwestern Medical Center at Dallas USANot available on demand12 45 13 00Closing Remarks and Poster Prize Announcements13 00 13 15Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 350On site PhD Student 250On site Industry 750On site Journal Editors 200Virtual Academia 150Virtual PhD Student 100Virtual Industry 250 Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Catherine Casas Saavedra for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact Catherine Casas Saavedra for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops For DFG Grants participants must travel in economy class no business travel will be covered and the hotel accommodation should not exceed 95 EUR per night The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Tuesday 23 January in some cases at special rates Please email the hotel directly quoting the booking code NCB24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityB B HotelLeonardo Hotel Heidelberg City CentreISG Hotel Exzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Childcare For more information please contact CRC1550 Heidelberg University Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Talks will only be recorded upon speaker s consent Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Gold sponsor Silver sponsor Event sponsor Bruker Event supporter Disease Models Mechanisms The Company of Biologists Media partners EMBO Molecular Medicine an EMBO Press journal Development The Company of Biologists journal International Union of Biochemistry and Molecular Biology Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl org for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 Pre conference workshop For on site participants only This industry workshop will be hosted by our sponsor IVIM Technology prior to the EMBO Workshop The new cardiobiology on Tuesday 20 February 2024 11 45 12 45 Participation in this workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served All registered conference attendees will receive an email with a registration link shortly ABSTRACT Suction assisted Imaging Window for Stabilized Intravital Imaging of Lung and Heart in a Live Animal Pilhan Kim Ph D Professor Korea Advanced Institute of Science and Technology KAIST Graduate School of Medical Science and Engineering Republic of Korea Download full abstract with images here...

Pilar Alcaide, Johannes Backs, Tina Haase, Enzo Porrello

19 February - 23 February 2024

Exploring gene and environmental exposure interactions to understand human health and disease

Description This introductory course explores the complex interplay between genes and the environment in shaping human phenotypes Participants will gain knowledge of cohort datasets environmental readouts and computational resources to investigate gene environment interactions Ethical and legal frameworks related to data privacy consent and genetic discrimination will be discussed The course also covers computational modelling techniques for integrating genotype and environmental effects By the end attendees will be equipped to analyse cohort datasets make use of computational resources and interpret the results Please note that you will not analyse your own data as part of the course There will however be ample opportunity to discuss your research and ideas with other course participants and trainers...

Sophie Spencer

14 February 2024

Investigating microbial ecology in extreme habitats

Description Understanding the mechanisms by which microorganisms have adapted over geological time is crucial in anticipating how they will evolve in the future in the light of climate change and global warming Changes in climatic conditions may drive ecosystems which are currently characterised by average levels of main environmental parameters into the extreme which may in turn lead to higher abundances of extremophilic microbes The advent of high throughput sequencing has allowed researchers to further explore microbiomes in extreme habitats and investigate the mechanisms that they employ to overcome such hostile conditions This webinar will discuss publicly available shotgun metagenomics data from various extreme habitats It will also showcase how data processing with state of the art tools can provide valuable insights regarding the genomic potential of the microorganisms who inhabit such habitats You may either watch the entire presentation from the introduction or navigate directly to a specific section by clicking the links provided below IntroductionWhat is EMBRCExtreme habitats and extremophilesMethods and challenges to study extremophilesmetaGOflowClimate change and thermophilesQ A...

12 February - 16 February 2024

Introduction to RNA-seq and functional interpretation

Description Gain an introduction to the technology data analysis tools and resources used in RNA sequencing and transcriptomics The content will provide a broad overview of the subject area and introduce participants to basic analysis of transcriptomics data using the command line It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data Topics will be delivered using a mixture of lectures practical exercises and open discussions Computational work during the course will use small example data sets and there will be no opportunity to analyse personal data Virtual course Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 00 16 00 hrs GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Juanita Riveros

8 February 2024

Sequence analysis tools in UniProt: BLAST and Align

Description UniProt provides the scientific community with a freely accessible collection of protein sequences and functional information and is one of the most widely used protein resources in the world BLAST and the multiple sequence alignment are essential methods commonly used to find and compare protein or nucleotide sequences In this webinar we will demonstrate how you can access and run these sequence analysis tools in UniProt We will show you how to navigate the results and how you can exploit UniProt protein annotation to expand further the analysis of your results...

4 February - 9 February 2024

Analysis and integration of transcriptome and proteome data

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells tissues and organisms operate in their biological context Among the key technologies driving this forward are next generation sequencing and proteomics as they provide powerful means to determine global expression levels of genes and proteins Both fields have matured to a degree that they have now become accessible to researchers in many areas of biology During this course participants will gain theoretical insight in the structure of sequencing and proteomic data and they will receive training in data analysis for the annotation quantification and statistical analysis of gene and protein expression using various computational tools In addition training will be provided in the use of Cytoscape to derive biological insights from the integration of both data types Audience This course is targeted at biologists and biochemists who are starting to be involved in both next generation sequencing and mass spectrometry based proteomics but who are not experts in these fields Modules resources Principles of mRNA quantification Principles of protein identification and quantification Principles and application of bioinformatic tools for mining of transcriptome and proteome data Data integration by Cytoscape Learning outcomes The aim of this practical course is to provide insight in techniques that are frequently used for transcriptome and proteome analysis and to provide hands on experience turning primary data into information that can be used for further biological interpretation To achieve these goals participants will gain insight in the basic principles of gene expression analysis RNAseq data quantification and differential expression analysis protein identification and quantification and they will be trained in the use of software tools to analyse sequencing and proteomic data SearchGUI PeptideShaker MaxQuant In addition the course will provide insight in the complementarity of transcriptome and proteome data by their integrative analysis via Cytoscape What past participants say about the course An intensive and inspiring course with worldwide top researchers in bioinformatics Ideal for wet lab scientists who are now starting to work on RNA seq and proteomics analysis Marta Furtado Instituto de Medicina Molecular Portugal In this course I found lecturers and participants equally willing to share and learn This together with the high quality of each lecture and the care of the organisers contributed to make this week a life changing experience for me Maria Cristina Petrella Centre for Genomic Regulation CRG Spain Speakers Speakers Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Hyungwon Choi National University of Singapore Singapore Daria Fijalkowska University of Ghent Belgium Jeroen Krijgsveld DKFZ Germany Manjeet Kumar EMBL Heidelberg Germany Jonathan Landry EMBL Heidelberg Germany Lennart Martens University of Ghent Belgium Gerben Menschaert University of Ghent Belgium Scooter Morris University of California San Francisco USA Kristina Rou ov Charles University Czech Republic Santhust Mikhail Savitski EMBL Heidelberg Germany Scientific organisers Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Daria Fijalkowska University of Ghent Belgium Jeroen Krijgsveld German Cancer Research Centre DKFZ Germany Lennart Martens VIB University of Ghent Belgium Course organisers Inna B sselmann Course and Conference Manager EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Officer EMBL Heidelberg Germany Programme Are you on social media Post using EMBLDataIntegration and don t forget to tag EMBLEvents Some pre course work watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course All times in the programme below are shown as the time in Europe Berlin Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 4 February 2024 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 09 15 Arrival welcome and safety introductionsCourtyard Room09 15 11 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard Room11 00 11 30Coffee breakCourtyard Foyer11 30 12 30RNAseq Reads to genes Raffaele Calogero University of Torino Italy Kristina Roucova Charles University Czech RepublicCourtyard Room12 30 13 30LunchEMBL Canteen13 30 16 00Practical From Reads to Genes Single cell RNA seq Raffaele Calogero University of Torino ItalyKristina Roucova Charles University Czech RepublicComputer Training Lab16 00 16 30Coffee breakATC Foyer16 00 18 00Q A on RNAseq and scRNAseqComputer Training Lab18 00Departure to ISG HotelATC entrance18 30DinnerISG Hotel Day 2 Monday 5 February 2024 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00Flash talk presentationsComputer Training Lab10 00 12 30Practical theory Differential expression analysisRaffaele Calogero University of Torino ItalyJonathan Landry EMBL Heidelberg GermanyKristina Roucova Charles University Czech Republicwith flexible coffee breakComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Practical session Ribosome profilingGerben Menschaert University of Ghent BelgiumComputer Training Lab16 00 16 30Coffee breakComputer Training Lab16 30 18 30Lecture practicals Ribosome profilingGerben Menschaert University of Ghent BelgiumComputer Training Lab18 30 19 45 DinnerEMBL Canteen19 45Departure to ISG HotelATC entrance Day 3 Tuesday 6 February 2024 Time Europe Berlin SpeakerLocation08 40 09 00 Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 11 00Introduction to ProteomicsJeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab11 00 11 30Coffee breakFoyer11 30 12 30Lecture Quantitative proteomics SILAC and other MS1 based approachesJeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 00Lecture Quantitative proteomics TMTMikhail Savitski EMBL Heidelberg GermanyComputer Training Lab15 00 16 00Lecture Bioinformatics for proteomicsLennart Martens University of Ghent BelgiumComputer Training Lab16 00 16 30Coffee BreakComputer Training Lab16 30 18 00Q A to Bioinformatics for proteomicsLennart Martens University of Ghent BelgiumComputer Training Lab18 00 Shuttle to the restaurantATC entrance18 30Social dinner downtownEMBL Canteen Day 4 Wednesday 7 February 2024 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00Practical Session Turning data into information peptide and protein identification database searchingLennart Martens University of Ghent Belgiumwith flexible coffee breakComputer Training Lab10 00 10 30Coffee breakATC Foyer10 30 12 00Lecture Introduction to MaxQuant analysis of MS dataDaria Fijalkowska University of Ghent BelgiumComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Practical Session Proteomics data interpretationDaria Fijalkowska University of Ghent BelgiumComputer Training Lab14 30 16 15Lecture P values and multiple testing correctionHyungwon Choi National University of Singapore SingaporeComputer Training Lab16 15Free afternoon16 15Departure to ISG Hotel and downtownATC entrance Day 5 Thursday 8 February 2024 TimeSpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00 Q A to Bioinformatic tools for data comparison and integrationJohn Scooter Morris University of California San FranciscoComputer Training Lab10 00 10 30 Coffee break Foyer10 30 12 30Practical Introduction to CytoscapeManjeet Kumar EMBL Heidelberg GermanyJohn Scooter Morris University of California San Francisco USASanthust EMBL Heidelberg GermanyComputer Training Lab12 30 13 30Lunch group photoEMBL Canteen13 30 15 00Practical Introduction to CytoscapeManjeet Kumar EMBL Heidelberg GermanyJohn Scooter Morris University of California San Francisco USAComputer Training Lab15 00 16 15 Lecture and Practical Enrichment analysisManjeet Kumar EMBL Heidelberg GermanyJohn Scooter Morris University of California San Francisco USAComputer Training Lab16 15 16 45 Coffee BreakFoyer16 45 17 45 Application talk Network oriented integrative multi omics analysis of tissues and fluids case studies in cancer and cardiovascular diseasesHyungwon Choi National University of Singapore Singapore Computer Training Lab17 45 18 45DinnerEMBL Canteen18 45Shuttle to ISG HotelATC entrance Day 6 Friday 9 February 2024 Time SpeakerLocation08 40 09 00 Bus from ISG Hotel to EMBL ATC entranceISG hotel bus stop09 00 12 00 Practical Session Data integrationJohn Scooter Morris University of California San Francisco USAwith flexible coffee break Computer Training Lab12 00 13 00LunchEMBL Canteen13 00 15 00Practical Session Data integrationJohn Scooter Morris University of California San Francisco USA Computer Training Lab15 00 15 30Course wrap up and farewell Computer Training Lab15 30Departure to Train Station ATC entrance Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 715PhD Student 715Industry 1225 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers trainers and organisers when attending a course Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the registration fee Participants are expected to book and pay for their own accommodation A mix of single and twin rooms have been reserved for 6 nights 3 9 February 2024 at the ISG Hotel Single rooms are limited and will be available on a first come first served basis After the selection process selected participants should contact the hotel directly to make a booking with a booking code PRO24 01 by the deadline of 8 January 2024 We recommend that all course participants stay in the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Raffaele Calogero, Jeroen Krijgsveld, Lennard Martens

31 January 2024

Exploring target-disease associations with the Open Targets Platform’s new interface

Description The Open Targets Platform https platform opentargets org is a comprehensive research tool that supports systematic identification and prioritisation of potential therapeutic drug targets By integrating publicly available datasets along with data generated by the Open Targets consortium the Platform builds and scores target disease associations Users can also explore relevant annotation information about targets diseases phenotypes and drugs as well as their most relevant relationships This webinar will provide an introduction to the capabilities and use cases for the Open Targets Platform and demonstrate two newly introduced features The new associations view enables users to dynamically modify the relative importance of the different data sources on the fly and the Target Prioritisation view provides an assessment of target specific properties of interest when evaluating the suitability of a target for a drug discovery programme There are major steps in our ongoing effort both to refresh the look and feel of the Platform and to enhance the Platform s capabilities to help build therapeutic hypotheses...

29 January - 31 January 2024

Cryo-EM in academia and industry

Description OverviewSpeakersProgrammePractical informationSponsors PartnersIndustry workshopsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually For late registrations please contact Lea Hohmann Due to the announced railway strike in Germany there will be additional buses on Sunday evening 28 January and Monday morning 29 January from Frankfurt Airport to Heidelberg Sunday 28 01 Frankfurt Airport Terminal 1 P36 Departure 23 00 to Heidelberg Main Station Monday 29 01 Frankfurt Airport Terminal 1 P36 Departure 10 00 to EMBL More information will be shared with all participants shortly Conference overview The second edition of this workshop aims to bring the academic and industrial cryo EM communities together to evaluate how the use of cryo EM has developed 10 years on from the cryo EM resolution revolution and build upon the successful first edition held at EMBL in 2019 Showcasing high quality research in academia and industry relevant and exemplary for both cryo EM communities the meeting will provide updates on recent and ongoing methodological developments A particular focus will be on the integration of cryo ET and cryo EM with complementary imaging techniques e g imaging across scales as well as other omics technologies such as proteomics genomics and metabolomics The integration of cryo EM in the drug discovery workflow will also be examined This event is part of the iNEXT Discovery activities and is co organised with the Netherlands Cancer Institute NKI iNext Discovery is structural biology project funded from the European Commission Horizon 2020 scheme Its main aim is to provide enable access to structural biology research infrastructures for all European researchers Session topics Cryo EM in industry workflows Cryo EM applications in research Cryo EM for integrative structural biology Recent developments in cryo EM Access to cryo EM for industry and academia What past participants say about the conference The feedback from our first workshop has been very positive 100 of our participants stated that they would attend a repeat of this event This was my first experience of an EMBL advanced training centre conference and I hope it won t be my last The quality of the scientific discussion training and opportunities for networking were exceptional Mohammad Bahar University of Oxford UK This workshop gave me an excellent overview of current opinions in the field Hans Raaijmakers Thermo Fisher Scientific Speakers Keynote Speaker Carsten Sachse Forschungszentrum J lich GmbH Germany Speakers Andreas Boland University of Geneva Switzerland Doryen Bubeck Imperial College London UK Claudio Ciferri Genentech USA Tristan Croll Altos Labs USA Ilaria Ferlenghi GSK Italy Julia Mahamid EMBL Heidelberg Germany Marion MacFarlane University of Cambridge UK Francesca Ester Morreale The Francis Crick Institute UK Gergely Papp EMBL Grenoble France Anastassis Perrakis Netherlands Cancer Institute iNEXT Discovery The Netherlands Giovanna Scapin Nanoimaging Services USA Jeremy Sloan BASF Germany Andrew Ward Scripps Research USA Denis Zeyer NovAliX France Peijun Zhang eBIC Electron Biology Imaging Centre UK Ellen Zhong Princeton University USA virtual speaker Scientific Organisers Chun wa Chung GSK UK Simone Mattei EMBL Heidelberg Germany Christoph M ller EMBL Heidelberg Germany Chiara Rapisarda Sanofi France Conference Organisers Edward Avenell EMBL Heidelberg Germany Lea Hohmann EMBL Heidelberg Germany Programme Are you on social media Post using EMBLCryoEM and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 29 January 2024 Time Europe Berlin Speaker12 00 13 45Registration and light refreshments12 30 13 30Industry workshop Facilitating cryo EM by further automation Smart EPU and Tomo Live Software by Thermo Fishher Scientific registration required 13 45 14 00Opening remarks by Simone Mattei14 00 17 15Session 1 Cryo EM in Industry WorkflowsSession chair Chiara Rapisarda14 00 14 45Keynote Lecture Towards next generation cryo EM imaging and visualization of heterogeneous membrane remodeling systemsCarsten Sachse Forschungszentrum J lich GmbH GermanyNot available on demand14 45 15 15Rigid Fabs enable high resolution structure determination of small proteins by cryoEMClaudio Ciferri Genentech USA15 15 15 45From implementing cryo EM to effectively supporting structure based drug design an 8 year journey at NovAliXDenis Zeyer NovAliX France15 45 16 15Coffee Break16 15 16 45Novel Insight Drive Innovation for Successful AgricultureJeremy Sloan BASF GermanyNot available on demand16 45 17 00The industrialisation of cryo EM at Astex Pharmaceuticals a facility geared towards structure based drug designJoanna Brown Astex Pharmaceuticals UK17 00 17 15CryoEM a powerful tool for structure based high throughput epitope mapping of Next Generation BiologicsMadhumati Sevvana Sanofi USA17 15 17 45Coffee Break17 45 19 15Poster Session19 15 20 45Dinner in Canteen20 45 22 15After dinner drinks in ATC Rooftop Lounge Day 2 Tuesday 30 January 2024 Time Europe Berlin Speaker09 00 12 00Session 2 Cryo EM Applications in ResearchSession chair Christoph M ller09 00 09 30Controlling complementDoryen Bubeck Imperial College London UK09 30 10 00Visualising proteolytic complexes in action the small molecule switchFrancesca Ester Morreale Research Institute of Molecular Pathology Austria10 00 10 30Molecular Architecture of FADD Caspase 8 Signalling Complexes from assembly to co ordinated control of Life Death DecisionsMarion MacFarlane University of Cambridge UK10 30 11 00Coffee Break11 00 11 15Cryo EM imaging of replicative helicase loading with yeast and human proteinsJulia Greiwe The Francis Crick Institute UKNot available on demand11 15 11 30Large scale conformational changes in a spliceosomal RNA helicase induced by allosteric inhibitorsGopika S Freie Universit t Berlin Germany11 30 11 45Structural journey of an insecticidal protein against western corn rootwormGuendalina Marini CSSB GermanyNot available on demand11 45 12 00Cryo EM to study CRISPR Cas interference and adaptation for type I multiprotein effectorsInga Songailiene Vilnius University LithuaniaNot available on demand12 00 13 30Meet the speakers and Lunch12 30 13 15Industry workshop Recent Advances in Grid Technology by Quantifoil registration required 13 30 17 00Session 3 Cryo EM for Integrative Structural BiologySession chair Chun wa Chung13 30 14 00Enabling discovery by in cell structural biologyJulia Mahamid EMBL Heidelberg GermanyNot available on demand14 00 14 30Universal strategies in cryoEM to visualize small drug targetsAndreas Boland University of Geneva Switzerland14 30 15 00Accelerating vaccine discovery by multidisciplinary structural and digital innovative approaches combinationIlaria Ferlenghi GSK Italy15 00 15 30Coffee Break15 30 16 00From structure to sequence Antibody discovery using cryoEMAndrew Ward Scripps Research USA16 00 16 15Finding antibodies in cryo EM densities with CrAIChiara Rapisarda Sanofi France16 15 16 30Structural Analysis of COPI Pathway in Chlamydomonas reinhardtiiGrigory Tagiltsev Max Planck Institute of Biochemistry Germany16 30 17 00Coffee Break17 00 19 30Session 4 Recent Developments in cryo EMSession chair Anastassis Perrakis 17 00 17 30CryoDRGN Advances in deep learning for reconstructing structure and dynamics in vitro and in situ Ellen Zhong Princeton University USA remote talk17 30 18 00Physics based interactive modelling with ISOLDETristan Croll Altos Labs USA18 00 18 30EasyGrid automated sample preparation and control for cryo imaging experimentsGergely Papp EMBL Grenoble FranceNot available on demand18 30 18 45Short break18 45 19 00Towards a better understanding of sample preparation within single particle cryo EMStephen Muench University of Leeds UK19 00 19 15CCP EM Pipeliner Doppio Software tools for efficient accurate and reproducible management and automation of cryoEM processing workflowsMatthew Iadanza UKRI UK19 15 19 30Troubleshooting cryo EM sample preparation through cryo EM grid hardware past present and futureWouter Van Putte Puxano Belgium19 30 21 00Dinner in Canteen21 00 23 00After Dinner Drink Live Jazz Day 3 Wednesday 31 January 2024 Time Europe Berlin Speaker09 00 12 15Session 5 Access to cryo EM for Industry and AcademiaSession chair Simone Mattei09 00 09 30Cryo EM in industry still challenging but many opportunitiesGiovanna Scapin Nanoimaging Services USA09 30 10 00Visualizing macromolecular structures in situ by cryo electron tomographyPeijung Zhang eBIC Electron Biology Imaging Centre UKNot available on demand10 00 10 30Opportunities for using the iNEXT Discovery access program and a future outlook to services for structural biologyAnastassis Perrakis NKI iNEXT Discovery The Netherlands10 30 11 00Coffee Break11 00 11 30Structures of human tRNAs by single particle cryo EMSebastian Glatt Jagiellonian University Krakow Malopolska Centre of Biotechnology PolandNot available on demand11 30 11 45Cryo EM User facility at the Ernst Ruska Centre Forschungszentrum J lich Germany Thomas Heidler Forschungszentrum Juelich Germany11 45 12 45Round Table Discussion on Future perspectives and sustainability for cryo EM in industryPanel members Anastassis Perrakis and more to be confirmed12 45 13 00Closing Remarks and poster prizes13 00 14 30Lunch followed by departure13 15 14 15Imaging Centre ToursSeparate Registration required please await further information before event14 30Airport shuttle to Frankfurt airport terminal 1 30 EUR tickets may be purchased on site Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 750On site PhD Student 550On site Industry 1050Virtual Academia 225Virtual PhD Student 175Virtual Industry 275 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Lea Hohmann for more information Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 3 January 2024 in some cases at special rates Please email the hotel directly quoting the booking code CPP 24 01 to confirm the exact price of the room Hotel ibis HeidelbergPremier Inn Heidelberg CityISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreMeininger Heidelberg Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Please see the bus schedule HERE as of 24 January 2024 Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 Additional buses due to railway strike free of charge Sunday 28 01 Frankfurt Airport Terminal 1 P36 Departure 23 00 to Heidelberg Main Station Monday 29 01 Frankfurt Airport Terminal 1 P36 Departure 10 00 to EMBL View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for two weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Partners Event partner Gold sponsor Silver sponsor Bronze sponsor Event sponsorCryoSol WorldEvent supporter Media partners EMBO Reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Imaging and Microscopy a Wiley magazine Medinformatics a Bon View Publishing journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Industry workshops For on site participants only The following industry workshops will be hosted by the sponsors of EMBL Industry Workshop Cryo EM in academia and industry during the event on Monday 29 January 2024 12 30 13 30Facilitating cryo EM by further automation Smart EPU and Tomo Live Software by Dr Rebecca Thompson and Dr Julio Ortiz Thermo Fisher Scientific on Tuesday 30 January 2024 12 30 13 15Recent Advances in Grid Technology by Dr Claire Naylor and Dr Paul Thaw Quantifoil In order to read the abstract of each workshop please click on the corresponding links above Participation in these workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served You may register for and attend to both workshops All registered conference attendees will receive an email with a registration link shortly Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Edward Avenell, Chun-wa Chung, Simone Mattei, Christoph Mueller, Chiara Rapisarda

22 January - 26 January 2024

Exploratory analysis of biological data: data carpentry

Description OverviewSpeakersProgrammePractical informationMedia kit Overview Course overview The missing step between data collection and research progress is a lack of training for researchers in crucial skills for effectively managing and analysing data often in large amounts This hands on workshop teaches researchers the fundamental data skills they need to conduct their work and provides high quality domain specific training covering the full lifecycle of data driven research The domain specific approach allows participants to tailor the data content and tools to reflect the specific data and analysis needs of different areas Audience The course is aimed at graduate students and other researchers in the life sciences who would like to learn good practices in project and data organisation and computational data analysis with R The course is ideally suited to students without prior experience in computational research but some familiarity with working with tabular data on a computer is welcome Modules Data organisation and cleaning Versioning with Git Introduction to R Data analysis and visualisation in R Data analysis with applications to genomics Learning outcomes How to organise data and some practices for more effective data handling To effectively clean and format data and automatically track any changes To use R to handle filter and summarise tabular data To use the split apply combine concept for data analysis To visualise the results of these analyses in R using the ggplot2 library To apply all of the concepts in an exploratory analysis of a typical biological dataset What past participants say about the course The best course to take first steps in data analysis I learned a lot and wholeheartedly recommend it to everyone learning to program for science purposes Magdalena Ziemianska Maj Institute of Pharmacology Polish Academy of Sciences Poland Excellent course to learn basics of R A very friendly group of instructors who were easy to interact with and patient with all the queries we had Also the organisation team made it very easy for us the pre and post course preparations and also during the stay Balagopal Pai University of Regensburg Germany Speakers Speakers trainers and staff Renato Alves EMBL Heidelberg Germany Gaurav Diwan University of Heidelberg Germany Stella Fragkouli Center for Research and Technology Hellas CERTH Greece virtual Ece Kartal University of Heidelberg Germany Supriya Khedkar EMBL Heidelberg Germany Eleonora Mastrorilli EMBL Heidelberg Germany Lisanna Paladin EMBL Heidelberg Germany Nikos Pechlivanis Center for Research and Technology Hellas CERTH Greece virtual Fotis Psomopoulos Center for Research and Technology Hellas CERTH Greece virtual Christian Schudoma EMBL Heidelberg Germany Francesco Tabaro EMBL Rome Italy Vasileios Vasileiou Center for Research and Technology Hellas CERTH Greece virtual Tristan Wiessalla EMBL Rome Italy virtual Scientific organisers Renato Alves EMBL Heidelberg Germany Lisanna Paladin EMBL Heidelberg Germany Fotis Psomopoulos Center for Research and Technology Hellas CERTH Greece Christian Schudoma EMBL Heidelberg Germany Course organisers Iva Gavran Course and conference officer EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Are you on social media Post using EMBLDataCarpentry and don t forget to tag EMBLEvents Some pre course work in the form of preinstalling software and attending a pre course onboarding session will be required Details will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change On boarding session Monday 15 January 2024 Time Europe Berlin SpeakerLocation15 00 17 00On boarding session and Q A regarding software installationRenato Alves EMBL Heidelberg GermanyLisanna Paladin EMBL Heidelberg GermanyFrancesco Tabaro EMBL Rome Italyvirtual Day 1 Monday 22 January 2024 Time Europe Berlin SpeakerLocation10 45 11 00Bus from hotel to EMBL ATC EntranceISG Hotel11 00 11 15Welcome and house notes and course overview by scientific organisersCourtyard Room A B11 15 12 15FlashtalksCourtyard Room A B12 15 13 15LunchEMBL Canteen13 15 14 15Lecture Data Organization in SpreadsheetsLisanna Paladin EMBL Heidelberg GermanyCourtyard Room A B14 15 14 35Coffee breakCourtyard Foyer14 35 16 05Lecture OpenRefine for Data CleaningLisanna Paladin EMBL Heidelberg GermanyCourtyard Room A B16 05 16 20Coffee breakCourtyard Foyer16 20 17 50Lecture OpenRefine for Data Cleaning continued Lisanna Paladin EMBL Heidelberg GermanyCourtyard Room A B17 50 18 50Networking sessionCourtyard Room A B18 50 19 50DinnerEMBL Canteen19 50 20 00Shuttle bus to hotelATC Entrance Day 2 Tuesday 23 January 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel09 00 11 00Practical session Versioning with Git using RStudio Fotis Psomopoulos Center for Research and Technology Hellas CERTH Greece virtual Courtyard Room A B11 00 11 30Coffee breakCourtyard foyer11 30 12 30Practical session Versioning with Git using RStudio Fotis Psomopoulos Center for Research and Technology Hellas CERTH Greece virtual Courtyard Room A B12 30 13 30Lunch breakEMBL Canteen13 30 15 00Practical session Introduction to REleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B15 00 15 30Coffee breakCourtyard foyer15 30 16 50Practical session Introduction to REleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B16 50 17 10Coffee breakCourtyard foyer17 10 18 30Practical session Introduction to REleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B18 30 19 30DinnerEMBL Canteen19 45 19 55Shuttle bus to ISG HotelATC Entrance Day 3 Wednesday 24 January 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel 09 00 11 00Practical session Data manipulation with dplyrSupriya Khedkar EMBL Heidelberg GermanyCourtyard Room A B11 00 11 30Coffee breakCourtyard foyer11 30 12 30Practical session Data manipulation with dplyrSupriya Khedkar EMBL Heidelberg GermanyCourtyard Room A B12 30 13 30Lunch breakEMBL Canteen13 30 15 00Practical session Data visualisation with ggplot2Francesco Tabaro EMBL Rome ItalyEleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B15 00 15 30Group photo and Coffee breakCourtyard foyer15 30 16 50Practical session Data visualisation with ggplot2Francesco Tabaro EMBL Rome ItalyEleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B16 50 17 10Coffee breakCourtyard foyer17 10 18 30Practical session Data visualisation with ggplot2Francesco Tabaro EMBL Rome ItalyEleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B18 30 19 30DinnerEMBL Canteen19 45 19 55Shuttle bus to ISG HotelATC Entrance Day 4 Thursday 25 January 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 50Lecture Data visualisation with ggplot2Francesco Tabaro EMBL Rome ItalyEleonora Mastrorilli EMBL Heidelberg GermanyCourtyard Room A B09 50 10 00Short coffee breakCourtyard foyer10 00 10 50Practical session Data analysis with applications to genomicsGaurav Diwan University of Heidelberg GermanyCourtyard Room A B10 50 11 20Coffee breakCourtyard foyer11 20 12 20Practical session Data analysis with applications to genomicsRenato Alves EMBL Heidelberg GermanyCourtyard Room A B12 20 13 20Lunch breakEMBL Canteen13 20 14 50Practical session Data analysis with applications to genomicsRenato Alves EMBL Heidelberg GermanyCourtyard Room A B14 50 15 20Coffee breakCourtyard foyer15 20 17 00Practical session Data analysis with applications to genomicsRenato Alves EMBL Heidelberg GermanyCourtyard Room A B17 00 17 30Shuttle bus to downtownATC Entrance 17 30 19 00Free time19 00 21 30Downtown dinnertbd Day 5 Friday 26 January 2024 Time Europe Berlin SpeakerLocation08 40 08 55Bus from hotel to EMBL ATC EntranceISG Hotel09 00 10 30Practical session Data analysis with applications to genomicsFrancesco Tabaro EMBL Rome ItalyCourtyard Room A B10 30 11 00Coffee breakCourtyard foyer11 00 12 00Practical session Data analysis with applications to genomicsFrancesco Tabaro EMBL Rome ItalyCourtyard Room A B12 00 13 00Lunch breakEMBL Canteen13 00 14 00Debrief and wrap upCourtyard Room A B14 00 14 30Shuttle bus to Heidelberg main train stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 15 on site and 15 virtual participants For selection purposes please note that your application will not be considered without a letter of motivation and answering all additional questions Registration Onsite registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to live streamed course content lectures practical sessions discussion rounds as well as any learning activities in the virtual learning platform Onsite Academia 425Onsite PhD Student 425Onsite Industry 750Virtual Academia 190Virtual PhD Student 190Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset childcare costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a babysitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Accommodation is not included in the registration fee On site participants are expected to book and pay for their own accommodation Single rooms have been reserved for 5 nights 21 26 January 2024 at ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking with a booking code code of your course e g DTC24 01 by the deadline of 24 December 2023 We recommend that all course participants stay at the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the on site registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions and travelling to EMBL on our Information for Participants page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course On site participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software All participants will be requested to install software before the course Please make sure to bring the laptop with the installed software to the course You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions and travelling to EMBL on our Information for Participants page Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Renato Alves, Lisanna Paladin, Fotis E. Psomopoulos, Christian Schudoma

18 January 2024

Automated annotation in UniProt

Description UniProt is a high quality comprehensive protein resource in which the core activity is the expert review and annotation of proteins where the function has been experimentally investigated At the same time the UniProt database contains large numbers of proteins which are predicted to exist from gene models but which do not have associated experimental evidence indicating their function UniProt commits significant resources to developing computational methods for functional annotation of these predicted proteins based on the data in entries that have gone through the expert review process We will describe the two main automated annotation systems currently in use First UniRule which is an established UniProt system in which curators manually develop rules for annotation Second ARBA Association Rule Based Annotator which is a multi class learning system which uses rule mining techniques to generate concise annotation models ARBA employs a data exclusion algorithm that censors data not suitable for computational annotation and generates human readable rules for each UniProt release As part of our interest in engaging with the machine learning community we will also introduce the contribution of ProtNLM Protein Natural Language Model from Google Research which annotates proteins which have uncharacterised names We will also introduce UniFIRE an open source software that enables researchers to annotate their own protein dataset by using the above mentioned annotation systems In order to provide an easy and straightforward way to download and set up this tool we have containerised UniFIRE together with all its dependencies and the latest set of UniRule and ARBA rules In this webinar we will show how to create functional predictions for protein sequences by using this container image...

17 January 2024

An introduction to EMBL-EBI resources

Description EMBL EBI is the home of the world s most comprehensive range of freely available molecular databases and resources Our resources help researchers share and analyse data and perform complex queries in many different ways Join us for a tour of the core data resources at EMBL EBI During this webinar we will introduce the types of data available how you can search for data and the various ways of getting assistance We will also discuss the role of EMBL EBI in making data open and accessible and how you can include EMBL EBI data in your workflows We will also provide information on further online training to help you learn more about specific topics in bioinformatics and EMBL EBI resources including an introduction to the training collections The collections bring together videos and online tutorials on a specific topic to help get started...

14 December 2023

Uncovering protein function with UniProt

Description UniProt provides the scientific community with a freely accessible collection of protein sequence and functional information and is one of the most widely used protein resources in the world This webinar will cover what functional information is available in UniProt and where that information comes from It will also describe how the information is added to the resource and how to find it on the UniProt website...

12 December 2023

From transcriptomics to mechanistic models of signalling

Description Cellular signalling networks are the communication pathways that govern the behaviour of cells They allow cells to receive and process external signals such as growth factors and hormones and respond appropriately by activating specific gene expression programs or inducing cellular behaviours like proliferation migration and differentiation Disruptions in these signalling networks can lead to various diseases including cancer metabolic disorders and immune disorders Understanding the regulatory mechanisms of signalling networks is critical to developing effective therapies for these diseases One approach to discover signalling network alterations from omics data is through the use of upstream regulatory pathway analysis which aims to identify the transcription factors and upstream signalling regulators that control the expression of downstream genes This can be achieved through the joint analysis of omics data and the signalling network structure using methods such as CARNIVAL By using powerful algorithms and general purpose integer optimization solvers CARNIVAL explores the vast space of potential signalling alterations to identify a parsimonious signalling network that explains the measurements In this course participants will learn how to process differential gene expression data to estimate transcription factor activities with DecoupleR obtain and process prior knowledge networks with OmniPath and pypath and use CARNIVAL to infer signalling networks...

Daniel V. Thomas Lopez

6 December - 9 December 2023

Computational structural biology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview The field of computational structural biology is undergoing a revolution AlphaFold a program based on Artificial Intelligence AI has transformed the structural modeling of proteins and protein complexes by reaching accuracy similar to experimental structures Over 200 million structural models have already been released in AlphaFold Database Following AlphaFold other protein modeling programs proliferated from researchers worldwide AI has started advancing RNA modeling too The wealth of protein models has sparked an explosion of new tools for structural analysis and structure based function assignment Scientists from other fields such as system biology incorporate AI based structure prediction in their pipelines In parallel molecular dynamics simulations push the limits of accuracy and size of what can be simulated Protein and drug design are being transformed thanks to new geometric AI methods and the availability of structural models for almost any drug target With this Cambrian explosion of computational structural biology this event aims to become a so far missing major dedicated conference Our conference will update on the impact of AI based structure prediction provide a forum to present new methods and applications build a wider community by integrating the new scientists now massively joining the field and open a platform to discuss future directions and opportunities Session topics Modeling proteins and nucleic acids Modeling complexes Structural dynamics Structure based function assignment and analysis Structural bioinformatics and experiments Applications drug protein design and more Structural systems biology Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speakers Charlotte Deane University of Oxford UK Zaida Zan Luthey Schulten University of Illinois at Urbana Champaign USA Speakers David Ascher University of Queensland Australia Minkyung Baek Seoul National University South Korea David Baker University of Washington USA Virtual speaker Pedro Beltrao ETH Z rich Switzerland Alexandre Bonvin Utrecht University THe Netherlands Janusz Bujnicki International Institute of Molecular and Cell Biology in Warsaw Poland Arne Elofsson Stockholm University Sweden John Jumper DeepMind UK Tomasz Kosciolek Ma opolska Centre of Biotechnology UJ Poland Elodie Laine Sorbonne Universit France Adrian Mulholland University of Bristol UK Agnieszka Obarska Kosinska Max Planck Institute of Biophysics Germany Giulia Palermo University of California Riverside USA Juri Rappsilber Technical University of Berlin Germany Andrej Sali University of California San Francisco USA Ora Schueler Furman Hebrew University of Jerusalem Israel Virtual speaker Chaok Seok Seoul National University South Korea Virtual speaker Yuji Sugita RIKEN Cluster for Pioneering Research Japan Janet Thornton EMBL EBI UK Shruthi Viswanath National Centre for Biological Sciences India Scientific organisers Rommie Amaro University of California San Diego USA Jan Kosinski EMBL Hamburg Germany Christine Orengo University College London UK Sameer Velankar EMBL EBI UK Conference organiser Sophie Dutzi EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOComp3D Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 6 December 2023 Time Europe Berlin Session11 30 13 00Registration and light refreshments13 00 13 10Opening remarksSession 1 Modeling proteins and nucleic acidsSession Chair Sameer Velankar EMBL EBI UK13 10 13 40Building on AlphaFoldJohn Jumper Google DeepMind UK13 40 14 10Protein Structure and Interaction Prediction using RoseTTAFoldMinkyung Baek Seoul National University Republic of Korea14 10 14 25Cryo OrbiSIMS enables accurate 3D modelling of native RNA structures at atomic resolutionAditi Borkar University of Nottingham United KingdomVIRTUAL TALK14 25 14 40Integrating physics in deep learning algorithms a force field as a PyTorch moduleGabriele Orlando KU Leuven Belgium14 40 15 10Searching the molecular spaces using neural network energy modelsChaok Seok Seoul National University South KoreaNot available on demandVIRTUAL TALK15 10 15 40Computational modeling of RNA 3D structures and interactions with and without the use of experimental dataJanusz Bujnicki International Institute of Molecular and Cell Biology in Warsaw Poland15 40 16 10Coffee Break Meet the speakersSession 2 Modeling complexesSession Chair Zoe Cournia Biomedical Research Foundation of the Academy of Athens Greece16 10 16 40Towards a complete structural map of the human proteome using AlphaFoldArne Elofsson Stockholm University Sweden16 40 17 10Modeling protein peptide complexesOra Schueler Furman The Hebrew University of Jerusalem IsraelVIRTUAL TALK17 10 17 25Biophysics aware machine learning models for pMHC TCR binding predictionMartin Culka Columbia University USA17 25 17 40End to end deep learning model for accurate and high throughput prediction of antibody antigen complexesDina Schneidman The Hebrew University of Jerusalem Israel17 40 17 55Pairing interacting protein sequences using masked language modelingDamiano Sgarbossa EPFL Switzerland17 55 18 25Structural modeling of nuclear pore complexesAgnieszka Obarska Kosinska Max Planck Institute of Biophysics Germany18 25 20 00Dinner at EMBL Canteen20 00 22 00Pub Quiz and drinks in Canteen Day 2 Thursday 7 December 2023 Time Europe Berlin SessionSession 3 Structural dynamicsSession Chair Rommie Amaro University of California San Diego USA09 00 09 30In Situ Computational Microscopy of SARS CoV2Rommie Amaro University of California San Diego USA09 30 09 45Multiscale computer simulations reveal the role of membrane protein and water dynamics in energy production in mitochondriaVivek Sharma University of Helsinki Finland09 45 10 00Dissecting the structural basis behind higher specificity of FnCas9 proteinGayatri Panda Indraprastha Institute of Information Technology India10 00 10 30Multiscale Simulation for Drug resistance Enzyme Design and EvolutionAdrian Mulholland University of Bristol UK10 30 11 00Coffee Break Meet the speakers Meet the Editors11 00 11 15Computing residence time and investigating dissociation mechanisms of protein protein interactionsGiulia D Arrigo Heidelberg Institute for Theoretical Studies HITS Germany11 15 11 30Integrative modelling of glycans in the SARS CoV 2 spike protein and beyondMateusz Sikora Jagiellonian University Poland11 30 12 00The monomeric structures of GRB2 in solution by integrated modelingYuji Sugita RIKEN Japan12 00 12 30Flash talks 55 Barone Federico 73 de Vries Ida 97 Loison Claire 99 Hori Naoto 107 Justyna Marek 135 Mukherjee Sunandan 141 Paladino Antonella 149 Rinaldi Francesco 159 Shor Ben 165 Srivastava Mitul 171 Talagayev Valerij12 30 14 00Lunch meet the speakers and job fair14 00 15 00Poster Session 1 odd numbers View poster listing here15 00 15 30Coffee Break and Meet the speakers and ERC Session ERC funding opportunities Session 4 Structure based function assignment and analysisSession Chair Christine Orengo University College London UK15 30 16 00Computational Enzymology towards using knowledge of structure and function to identify paradigms of evolution and to predict enzyme mechanisms Janet Thornton EMBL EBI UK16 00 16 15The geometry of hidden representations of protein language modelsAlberto Cazzaniga AREA Science Park Italy16 15 16 30Towards the design of targeted therapeutics based on microbial and antimicrobial amyloidsPeleg Ragonis Bachar Technion Israel institute of Technology Israel16 30 17 00Applications of the new AI based modeling methods to annotate function of microbial proteins on an evolutionary scaleTomasz Koscio ek Jagiellonian University Silesian University of Technology Poland17 00 17 15Dissecting the sequence and structure determinants of gpcr gprotein selectivity via structural bioinformatics and machine learningMarin Matic Scuola Normale Superiore Italy17 15 17 45The impact of sequence variations on protein interactions and motionsElodie Laine Sorbonne Universit France17 45 Free afternoon Day 3 Friday 8 December 2023 Time Europe Berlin SessionSession 5 Structural bioinformatics and experimentsSession Chair Jan Kosinski EMBL Hamburg Germany09 00 09 45Keynote lecture Can machine learning understand the physics of binding Charlotte Deane University of Oxford UK09 45 10 15Towards accurate antibody antigen complex prediction from sequence using AI and integrative modellingAlexandre Bonvin Utrecht University The Netherlands10 15 10 45Localizing intrinsically disordered regions of proteins in integrative structures of large macromolecular assembliesShruthi Viswanath Tata Institute of Fundamental Research IndiaNot available on demand10 45 11 30Coffee Break Meet the speakers11 30 11 45Structure determination of an eIF2 dephosphorylation complex that terminates signalling in the integrated stress responseYahui Yan University of Cambridge United Kingdom11 45 12 15Visualising protein complexes inside cellsJuri Rappsilber Technische Universit t Berlin Germany12 15 12 30Inferring residue level hydrogen deuterium exchange with ReXOliver Crook University of Oxford United Kingdom12 30 12 45Enhanced modeling of water molecules in dynamic Protein Ligand structuresStephanie Wankowicz University of California San Francisco USA12 45 13 15Flash talks 62 Brandner Astrid 64 Bryant Patrick 78 Duman zge 82 Parra R Gonzalo 94 Haddad Bassam 100 Jalalypour Farzaneh 134 Molodenskiy Dmitry 170 Surpeta Bartlomiej 184 Wirnsberger Gregor13 15 14 45Lunch meet the speakers and job fair14 45 16 15Poster Session 2 even numbers View poster listing hereSession 6 Applications drugs protein design and moreSession Chair Katja Luck Institute of Molecular Biology Mainz Germany16 15 16 45Applications of computational methods to predict effects of disease related mutations and design drug moleculesDavid Ascher University of Queensland Australia16 45 17 00Predicting protein membrane interfaces using molecular simulations and ensemble machine learningZoe Cournia Biomedical Research Foundation Academy of Athens GreeceNot available on demand17 00 17 30Coffee Break Meet the speakers17 30 17 45Reality check evaluating generative models for protein and ligand designCharlie Harris University of Cambridge United Kingdom17 45 18 00Identification of HIV broadly neutralizing antibodies using a Deep Language ModelChiara Rodella University of Bern Switzerland18 00 18 30Design of new protein functions using deep learningDavid Baker University of Washington USA VIRTUAL TALK18 30 20 30Dinner at EMBL Canteen20 30 00 00Conference party with DJ Day 4 Saturday 9 December 2023 Time Europe Berlin SessionSession 7 Structural systems biologySession Chair Edward Marcotte The University of Texas at Austin USA09 30 10 15Keynote lecture 4D simulations of a growing minimal cellZaida Zan Luthey Schulten University of Illinois atUrbana Champaign USA10 15 10 45From integrative structural biology to cell biologyAndrej Sali University of California San Francisco USA10 45 11 00Interactions of pathogen metabolic and virulence processes revealed through deep learning and coevolutionIan Humphreys University of Washington USA11 00 11 30Coffee Break Meet the speakers11 30 11 45Combining AI structure prediction mass spectrometry and cryo EM to unlock the mysteries of motile ciliaCaitlyn McCafferty University of Basel Switzerland11 45 12 15Structure guided prediction of mechanistic impacts of human protein missense variantsPedro Beltrao ETH Z rich Switzerland12 15 13 00Round table discussion The future of computational structural biologyJanet Thornton Giulia Palermo Pedro Beltrao Andrej Sali13 00 13 15Closing Remarks and Poster Prize13 15 13 45Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact events embl de for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 8 November 2023 in some cases at special rates Please email the hotel directly quoting the booking code CSB23 01 to confirm the exact price of the room Hotel AnlageB B HotelMeininger HeidelbergStaycity Aparthotel HeidelbergHotel ibis HeidelbergHotel Bayrischer Hof Exzellenz HotelHotel Holl nder Hof Leonardo Hotel Heidelberg City CentreHotel MonptiPremier Inn Heidelberg CityHotel Vier Jahreszeiten Heidelberg Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Conference shuttle bus schedule The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Molecular Systems Biology an EMBO Press journal International Union of Biochemistry and Molecular Biology FEBS Open Bio a FEBS Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Jan Kosinski, Rommie Amaro, Christine Orengo, Sameer Velankar

4 December - 8 December 2023

Fundamentals of widefield and confocal microscopy and imaging

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Light microscopy is the most widely used form of microscopy for life science research The correct handling of the microscope and optimising image quality e g contrast resolution as well as experimental design according to different applications are crucial to obtain the best results This course will provide the participants with an overview of the basics of microscopy light and optics contrast techniques and imaging The confocal part will include multicolour 3D and time lapse imaging as well as spectral imaging photobleaching FRAP FLIP FLAP and photoactivation techniques Basic image analysis tools including measurement functions colocalisation and spectral unmixing as well as 3D 4D image processing will be covered both in theory and practice The course will combine lectures with intense daily hands on practices followed by discussions Audience This course is directed towards PhD students and faculty searching for instruction on light microscopy and basic image processing Modules resources Basics of optics and microscopy Contrast methods Basics of digital imaging Fluorescence microscopy Hands on sessions Learning outcomes Participants will get an overview about the basics of microscopy Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course This course is organised in cooperation with Evident Olympus Speakers Speakers trainers and staff Heiko Gaethje Evident Scientific Germany Stefan Marawske Evident Scientific Germany Stefan Terjung EMBL Heidelberg Germany Peter Vander Evident Scientific Germany Scientific organisers Heiko Gaethje Evident Scientific Germany Stefan Marawske Evident Scientific Germany Stefan Terjung EMBL Heidelberg Germany Jens Marquardt Evident Scientific Germany Course organisers Charlotte Courtney EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Soham Basu Predoctoral Fellow EMBL Heidelberg Germany Programme Are you on social media Post using EMBLWidefieldConfocal and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with an estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 4th December 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 15Arrival and welcome house notesFlex Lab A B09 15 13 00Basics of optics and microscopy Theoretical basics of light and optics Types of microscope frames and types of optics Set up bright field microscopes and the appropriate optics for different needs Cleaning centering adjusting and operating a microscope Basic set up and use of imaging devicesHands on session 1Flex Lab A B13 00 14 00LunchEMBL Canteen14 00 15 00Contrast methods Introduction into contrast methods phase contrast and differential interferencecontrast DIC Flex Lab A B15 00 17 30Contrast methods set up and alignment Set up and use of contrast methods phase contrast and differential interferencecontrast DICHands on session 2Flex Lab A B17 30 18 00Discussing open questionsFlex Lab A B18 00 19 00DinnerEMBL Canteen19 00Departure to HotelATC Entrance Day 2 Tuesday 5th December 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Arrival and coffeeFlex Lab A B09 00 12 30Basics of digital imaging Adaptation of digital cameras and theiralignment Interpretation of image content histogram anddigital filter functions Improving digital image contrastFlex Lab A B12 30 13 30LunchEMBL Canteen13 30 16 00Fluorescence microscopy I Introduction to fluorescence microscopy Setting up of microscopes and cameras for fluorescence observation The different types of illumination sources e g mercury xenon metal halide or LED Cubes filters and objectives Find the appropriate filter combination for a given fluorochrome and applicationHands on session 3Flex Lab A B16 00 17 30Discussing open questionsFlex Lab A B17 30 18 30DinnerEMBL Canteen18 30Departure to HotelATC Entrance Day 3 Wednesday 6th December 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC Entrance08 50 09 00Arrival and coffeeFlex Lab A B09 00 11 30Fluorescence microscopy II Auto fluorescence a source for noise Digital imaging for fluorescence microscopy Specific needs of digital cameras Digital multicolor handling Acquisition of multidimensional images 3D time Hands on session 3 continued Flex Lab A B11 30 11 35Group pictureFlex Lab A B11 35 12 30Guided tour of the EMBL Advanced light microscopy facility ALMF ALMF12 30 13 30LunchEMBL Canteen13 30 15 00Introduction to the confocal microscope Talk Flex Lab A B15 00 18 00Hands on session Group work Different applications will be covered in small groups Module 1 Multicolor imagingModule 2 Photomanipulation techniques FRAP FLIP and PhotoconversionModule 3 3D image collection and enhancement zooming resolution SNR z stacks IMARIS basicModule 4 Time lapse imaging bleaching and viability Multi Area Time Lapses and StitchingMicroscopy rooms18 00 18 30EMBL Bus via ISG Hotel to downtownATC Entrance18 30 20 00Gluhwein at the Christmas marketsWeihnachtsmarkt downtown Heidelberg20 00 22 00Dinner at KulturbraureiChristmas markets and then Kulturbraurei Day 4 Thursday 7th December 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Arrival and coffeeFlex Lab A B09 00 10 00FRAP and Photoconversion Talk Flex Lab A B10 00 13 00Hands on session Group work Work in ModulesMicroscopy rooms13 00 14 00LunchEMBL Canteen14 00 17 00Hands on session Group work Work in ModulesMicroscopy rooms17 00 18 00Comparative time lapse overnight experiment on three different setupsMicroscopy rooms18 00 19 00DinnerEMBL Canteen19 00Departure to HotelATC Entrance Day 5 Friday 8th December 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel08 50 09 00Arrival and coffeeFlex Lab A B09 00 09 30Evaluation and summaryof overnight timelapse acquisitionFlex Lab A B09 30 12 30Hands on session Group work Work in ModulesMicroscopy rooms12 30 13 00Tips and tricks for data presentationFlex Lab A B13 00 13 05Closing remarksFlex Lab A B13 05 13 15Packed lunchATC Foyer13 15EMBL Bus via ISG Hotel to main train stationATC Main entrance Practical information Registration fees and motivation letter The course is limited to 12 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 500PhD Student 500Industry 1 000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights Sunday 3rd December Friday 8th December 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code MIC23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and the location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Heiko Gaethje, Stefan Marawske, Jens Marquardt, Stefan Terjung

30 November 2023

Interpreting the effects of genetic variants on protein structure and function

Description Genetic variation between individuals results in a range of human phenotypes Variants that fall within coding regions of genes generally have direct and effects on the proteins encoded by the genes with which they overlap This four hour virtual workshop will provide participants with an opportunity to gain hands on experience of using EMBL EBI tools and resources to assess the effects of genetic variants on the structure and function of proteins in a common workflow During the course a single example will be used throughout using different EMBL EBI tools resources at each stage of the analysis pipeline The example will involve running a VCF file through the Ensembl Variant Effect Predictor VEP then following links to UniProt PDBe and AlphaFoldDB for further variant information and interpreation Virtual courseThis course will take place on Zoom Trainers will be available to assist answer questions and provide further explanations during the Zoom...

Meredith Willmott

29 November 2023

Studying metabolites and small molecules with MetaboLights and ChEBI

Description Metabolites are small molecules that play important roles in biological and cellular processes They act as signalling molecules serve as cofactors involved in energy production and storage and thus responsible for the maintenance growth and development of living organisms In this webinar we will first introduce metabolomics which focuses on the comprehensive analysis of metabolites within biological systems such as cells biofluids tissues or organisms from different ecosystems and health and environmental backgrounds In the second part of the webinar we will show how metabolite data is represented in MetaboLights an open access cross species and cross technique database for metabolomic experiments and derived information Studies in MetaboLights contain information across study design sample origin collection processing spectral data measurement data processing and metabolite identification The re use of data from MetaboLights can take various forms from identified metabolites towards interpretation with pathways reactions literature to a matrix for statistical modelling or even re processing of raw data In the final part of the webinar we will introduce MetaboLights partner database ChEBI that focuses on the nomenclature structure and biological properties of small molecules...

28 November - 1 December 2023

Subcortical sensory circuits: visual, auditory, somatosensory, and beyond

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Subcortical sensory circuits play a fundamental role in the perception of the outside world However they are often thought of as relay stations that passively transmit sensory information to the cortex or simple effectors of behavioral reflexes Recent studies however suggest that subcortical pathways also perform sophisticated computations such as integrating peripheral information among many sensory pathways and the animal s internal states This meeting will gather leading researchers in the field to discuss different subcortical circuits involving various sensory modalities and revisit their increasingly complex and interconnected contributions to perception behavior and cognition Furthermore we will delve into various topics which often play an interconnected role with sensory perception and are crucial to a detailed yet holistic understanding of perceptual circuits Topics Visual processing by the thalamus Circuits of the colliculus vision and multisensory integration Multisensory Integration and higher order thalamic nuclei Thalamocortical circuits of somatosensation Thalamic circuits for auditory perception The subcortical influence on decision making Development of subcortical circuits in mice and non human primates Thalamic modulation by glia The neuronal circuits underlying sleep Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speakers Sabine Kastner Princeton University USA Karel Svoboda Allen Institute USA Speakers Victoria Abraira Rutgers University USA Mark Andermann Harvard Medical School USA Hiroki Asari EMBL Rome Italy Martha Bickford University of Louisville USA Christian B chel University Hospital Hamburg Eppendorf Germany Laura Busse Ludwig Maximilians University Munich Germany Eunji Cheong Yonsei University Republic of Korea Christine Constantinople NYU Center for Neural Science USA Karl Farrow NERF Belgium Maria Geffen University of Pennsylvania USA Mike Halassa Tufts University USA Maria Florencia Iacaruso Francis Crick Institute UK Max J sch Institute of Science and Technology Austria Andrew King Oxford University UK Liang Liang Yale University USA Anita L thi University of Lausanne Switzerland David McAlpine Macquarie University Australia Carl Petersen EPFL Switzerland Santiago Rompani EMBL Rome Italy Tomomi Shimogori RIKEN Center for Brain Science Japan Scientific organisers Hiroki Asari EMBL Rome Italy Martha Bickford University of Louisville USA Carl Petersen EPFL Switzerland Santiago Rompani EMBL Rome Italy Conference organiser Aline Schnieder EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOSensoryCircuits Programme is preliminary and subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 28 November 2023 Time Europe Berlin Session Speaker12 00 13 00Registration and light refreshments13 00 13 15Opening remarks13 15 14 15Keynote lecture Computation in multi regional neural circuits with thalamus in the middleKarel Svoboda Allen Institute USANot available on demand14 15 15 00Better research panel discussion Improving job prospects for postdocs and tackling status inequality in hiringChair Santiago Rompani EMBL Rome ItalyPanellists Victoria Abraira Rutgers University USALaura Busse LMU Munich GermanyTomomi Shimogori RIKEN Center for Brain Science JapanKarel Svoboda Allen Institute USANot available on demand15 00 15 30Coffee Break and Meet the speakerSession 1 Subcortical influence on decision makingSession Chair Hiroki Asari15 30 16 00Thalamocortical control of cell type specificity drives a circuit for processing whisker related information in mouse barrel cortexTomomi Shimogori RIKEN Center for Brain Science Japan16 00 16 15What is a place cell Mayank Mehta University of California Los Angeles USA16 15 16 45Neural mechanisms of inferenceChristine Constantinople NYU USANot available on demand16 45 17 00Subcortical threats processing and non Hebbian consolidation of transient experiencesIslam Faress DANDRITE Aarhus University Denmark17 00 17 15The neural basis of defensive behaviour evolution in Peromyscus miceKatja Reinhard SISSA ItalyNot available on demand17 15 17 30Complex synaptic mechanisms between superior colliculus and thalamus during multisensory processesAnna Vir g Bakacsi Semmelweis University HungaryNot available on demand17 30 18 00Speed Networking 18 00 19 30Dinner19 30 21 00Welcome reception After dinner drinks Day 2 Wednesday 29 November 2023 Time Europe Berlin Session Speaker Session 2 Subcortical circuits for auditory perceptionSession Chair Santiago Rompani09 00 09 30Attentional modulation of subcortical auditory centres and sensory receptors in complex listening tasksDavid McAlpine Macquarie University Australia09 30 09 45Effective population coding of sound location by noisy neurons from the dorsal cortex of inferior colliculus in awake passively listening miceJuan Carlos Boffi EMBL Heidelberg GermanyNot available on demand09 45 10 15Subcortical circuits for auditory prediction and learningMaria Geffen University of Pennsylvania USA10 15 10 45Coffee Break and Meet the speakers10 45 11 00Network state changes in auditory thalamus represent learned outcomesJan Gr ndemann Deutsches Zentrum f r Neurodegenerative Erkrankungen DZNE Germany11 00 11 30Subcortical contributions to auditory processing and behaviourAndrew King University of Oxford UK11 30 12 00Flash talks odd numbers 39 Borb ly S ndor 41 Guarascio Domenico 43 Kamm Gretel 47 Magyar Aletta 49 Micheli Pietro 51 Myers Thomas 53 Nuttin Bram 55 Qu Mengdi 57 Schmidt Florian 61 Tortella Lorenza 63 Trpevski Daniel 65 Sumser Anton 67 Whitley JamesNot available on demand12 00 13 00Lunch and Meet the speakers Session 3 Visual processing by the thalamusSession Chair Martha Bickford13 00 13 30Functional organization of feeding related signals in the lateral parabrachial nucleusMark Andermann Harvard Medical School USA13 30 13 45Binocular integration of RGC boutons in the LGN can encode binocular summationTjasa Lapanja EMBL Rome Italy13 45 14 15Retinal ganglion cell axon binocularity in the mouseSantiago Rompani EMBL Rome ItalyNot available on demand14 15 14 45Coffee Break and Meet the speakers14 45 15 15Selective convergence of distinct excitatory inputs in the visual thalamus reinforces motion processingLiang Liang Yale University USANot available on demand15 15 15 30Flexible regulation of behavioural strategy during approach avoidance conflicts by the lateral geniculate nucleusAlice Monica Koltchev Sainsbury Wellcome Centre UK15 30 16 00Spiking activity in the visual thalamus is coupled to pupil dynamics across temporal scalesLaura Busse Ludwig Maximilians University of Munich Germany16 00 16 15Individual thalamic inhibitory interneurons are functionally specialized towards distinct visual featuresFiona Muellner Institute of Molecular and Clinical Ophthalmology Basel IOB SwitzerlandNot available on demand16 15 16 30An interpretable spline GLM to assess feedforward and feedback processing in mouse dLGNAnn Hossam Mohamed Kotkat Ludwig Maximilians University of Munich Germany16 30 18 30Poster Session odd numbers with beer and snacksView poster listing here18 30Free evening Day 3 Thursday 30 November 2023 Time Europe Berlin Session SpeakerSession 4 Colliculus circuits vision and multisensory integrationSession Chair Carl Petersen09 00 09 30Corollary discharge signals shape visuomotor transformation in the superficial superior colliculusMaximilian J sch Institute of Science and Technology Austria AustriaNot available on demand09 30 09 45Retinal origin of orientation but not direction selective maps in the superior colliculusDaniel de Malmazet MRC Laboratory of Molecular Biology UK09 45 10 15What does the eye tell the brain in vivo Hiroki Asari EMBL Rome ItalyNot available on demand10 15 10 45Coffee Break and Meet the speakers10 45 11 15Brain wide inputs to the superior colliculus and the modulating of innate behaviorsKarl Farrow VIB Belgium11 15 11 30Dendritic properties shape the responses of collicular wide field neurons to behaviorally relevant stimuliNorma K hn NERF Belgium11 30 11 45Characterization of visual response properties and connectivity of wide field vertical neurons in the mouse superior colliculusElise Savier University of Michigan USA11 45 12 15Flexible approach strategies support interceptive pursuit behaviour in miceMaria Florencia Iacaruso Francis Crick Institute UK12 15 13 30Lunch and Meet the speakersSession 5 Thalamocortical circuits of somatosensationSession Chair Hiroki Asari13 30 14 00Neuronal circuits for goal directed sensorimotor learningCarl Petersen EPFL Switzerland14 00 14 15Neural encoding of sensory surprise in the mouse brainDiego Benusiglio EMBL Rome Italy14 15 14 45Glial control of thalamic sensory processingEunji Cheong Yonsei University Republic of Korea14 45 15 15Coffee Break and Meet the speakers15 15 15 45Wired for Touch the story of how touch shapes our livesVictoria Abraira Rutgers University USA15 45 16 15The interaction of subcortical and cortical sensory circuits in pain processingChristian B chel University Hospital Hamburg Eppendorf Germany16 15 16 45Flash talks even numbers 38 Boone Howard 40 Ferrarese Leiron 42 Han Xu 44 Li Chen 46 Liu Chen 48 Mason Kierra 50 Molotkov Dmitry 52 Naeem Nazratan 54 Puvvada Madhuri 56 Sans Dublanc Arnau 58 Sokoloski Sacha 60 Susi Frank 62 Tripodi Matteo 64 Uran Cem 66 Gaspar Patricia 68 Zemmouri FirdaoussNot available on demand16 45 18 45Poster Session even numbers with beer and snacksView poster listing here18 45 20 30Conference dinner20 30 23 00Conference party in ATC Rooftop Lounge Day 4 Friday 1 December 2023 Time Europe Berlin Session SpeakerSession 6 Multisensory Integration and higher order thalamic nucleiSession Chair Santiago Rompani09 00 10 00Keynote lecture The cognitive visual thalamusSabine Kastner Princeton University USA10 00 10 15Parallel corticothalamic pathways from postrhinal cortex to pulvinar synaptic and physiological propertiesJulia Zaltsman Brown University USANot available on demand10 15 10 45Thalamic regulation of prefrontal dynamics in decision makingMichael Halassa Tufts University USA10 45 11 15Coffee Break and Meet the speakers11 15 11 45Integration of driver like inputs across the visual thalamusMartha Bickford University of Louisville USA11 45 12 15Being disconnected but remaining vigilant the neuroscience of opposing sleep functionsAnita Luthi University of Lausanne Switzerland12 15 12 30Closing Remarks and Poster Prize12 30 12 45Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Aline Schnieder for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and 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course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome 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regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 23 August 2023 in some cases at special rates Please email the hotel directly quoting the booking code SSC23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreHotel Vier Jahreszeiten HeidelbergExzellenz HotelMeininger HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings You can now find the conference bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions Where is the nearest Covid test centre Wo ist das n chste Covid Testzentrum HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Where is the nearest COVID 19 test centre Wo ist das n chste COVID 19 Testzentrum Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners EMBO reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Hiroki Asari, Martha Bickford, Carl Petersen, Santiago Rompani

23 November - 24 November 2023

Exploring EMBL-EBI sequence analysis tools and managing bioinformatics workflows

Description The European Bioinformatics Institute EMBL EBI offers a wide range of bioinformatics sequence analysis applications for free through web and programmatic access This two day course is designed to provide a comprehensive overview of sequence analysis tools and how to use the workflows effectively covering hands on exercises and demonstrations throughout The first day focuses on learning about the types of sequence analysis tools and how to use different tools in your analysis There will be a focus on sequence alignment e g Clustal Omega EMBOSS sequence similarity search tools mainly on how to perform Blast against the UniProt databases and using InterProScan for protein functional analysis The second day focuses on alternative methods of accessing the tools and how they help enhance flexibility in sequence analysis using web service clients and managing workflows...

Ajay Mishra

22 November 2023

Accessing single cell transcriptome data with the Human Cell Atlas Data Portal

Description The Human Cell Atlas is an ambitious project that aims to map the transcriptome of all the cell types in the human body This effort relies on single cell data generated from hundreds of labs across the globe which will be combined together into one comprehensive reference atlas The Data Portal helps to coordinate the data produced and standardise the format of data and metadata to reduce the burden of the integration efforts In this webinar we will provide an overview of data generation for HCA and how the data is curated for the Data Portal We will demonstrate how to navigate the Data Portal to find data that can be used for integration or as controls for your studies how to access the data and how to find the latest data from the integration efforts...

20 November - 24 November 2023

Genome bioinformatics: from short- to long-read sequencing

Description A guide to the technology analysis workflows tools and resources for next generation sequencing data analysis This course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data The main focus will be on introducing sequence informatics re sequencing differences between short and long read sequencing and variant calling during the analysis of higher eukaryotes with an emphasis on human genetic research Throughout the week more advanced topics will introduce the creation of pipelines automation and the scaling up of analysis experiments Practical sessions will be run on datasets prepared by the trainers not on personal research data Participants will learn how to process these training datasets and to apply appropriate statistical methods in their analyses...

Sophie Spencer

20 November - 22 November 2023

25th EMBL PhD Symposium

Description If you are not redirected automatically please go to PhD Symposium website...

2023 EMBL PhD Symposium Organising Committee

16 November 2023

Programmatic access to UniProt using Python

Description UniProt is a comprehensive expert led publicly available database of protein sequence function and variation information This webinar will give an overview of programmatic access to the UniProt database using Python and cover key aspects of protein entry searches data filtering batch downloads and give examples of further processing of downloaded target data Following a brief introduction to UniProt services where to find relevant documentation and help features the webinar will focus on worked examples These will include how to programmatically search and retrieve protein entries and sequences within the results we will then show how to align orthologous sequences and filter for features of interest The webinar will also cover programmatic examples of the UniProt ID mapping service batch downloads filtering and processing data...

15 November 2023

Complex Portal: from proteins to complexes

Description Complex Portal is a curated resource designed to offer insights into proteins and their higher level complexes These complexes play a crucial role in governing protein functionality and stability In this webinar we will introduce the portal and address how we define protein complexes how they are different from molecular interactions including the data curation priorities and coverage We will also demonstrate how to search complexes using a variety of accession numbers keywords and how to use the organism specific search Further we will also demonstrate examples of complex details pages that include visualisation tools and link outs to related databases...

15 November - 17 November 2023

Cancer genomics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPre conference workshop Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview This meeting will provide an opportunity to learn about and keep up to date with the rapidly progressing area of cancer genomics We aim to bring together scientists from across several disciplines connected with cancer research for a unique opportunity to interact and stimulate further integration of these efforts Highlights include talks from our keynotes Rebecca Fitzgerald University of Cambridge UK Jan Korbel EMBL Heidelberg Germany and 20 other great speakers Session topics Mutation and clonal selection Cancer evolution Cancer genome medicine Emerging technologies in cancer genomics Genomic instability and mutational processes Cancer ecosystems and micro environment What past participants say about the conference We have had excellent feedback on our past meetings where participating scientists specifically enjoyed the high quality of research presented which included ample presentation of unpublished data and the ability to interact with each other in this small to medium sized conference setting Excellent conference with good talks both from early stage and senior researchers Great opportunity to broadcast my work to experts in the field and to find potential scientific collaborators Isabel Duarte CINTESIS UAlg Portugal The EMBL Cancer Genomics conference perfectly synthesized scientific and technical innovation guided by leading scientists in the field Great experience Mila Gugnoni Laboratory of Translational Research AUSL IRCCS Reggio Emilia Italy Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote Speakers Rebecca Fitzgerald University of Cambridge UK Jan Korbel EMBL Heidelberg Germany Invited speakers Lauri Aaltonen University of Helsinki Finland Sam Behjati Wellcome Sanger Institute UK Aur lie Ernst German Cancer Research Center DKFZ Germany Lynnette Fernandez Cuesta International Agency for Research on Cancer IARC France Anton G Henssen Charit University Medicine Berlin Germany Mariam Jamal Hanjani UCL Cancer Institute UK Alice Lee Harvard University USA Geoff Macintyre CNIO Spanish National Cancer Research Center Spain Kamila Naxerova Harvard Medical School USA Sabarinathan Radhakrishnan National Centre for Biological Sciences Tata Institute of Fundamental Research India Daniela Robles Espinoza International Laboratory for Human Genome Research Mexico Hugo Snippert UMC Utrecht The Netherlands Andrea Sottoriva Human Technopole Italy Oliver Stegle EMBL Heidelberg Germany Patrick Tan Duke NUS Medical School Singapore Eliezer van Allen Dana Farber Cancer Institute USA Scientific Organisers Isidro Cortes Ciriano EMBL EBI UK Christina Curtis Stanford University USA N ria L pez Bigas Institute for Research in Biomedicine Spain Young Seok Ju Korea Advanced Institute of Science and Technology KAIST Republic of Korea Conference Organiser Chris Stocks EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLCanGen Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 15 November 2023 Time Europe Berlin Speaker10 30 12 00 Registration and light refreshments10 45 11 45Pre conference workshop Single Cell Genomics at scale Unlock single cell workflows with combinatorial indexing by Scale Biosciences registration required 12 00 12 15Opening remarks12 15 13 00Keynote lecture Harnessing cancer evolution for clinical benefit lessons from the oesophagusRebeca Fitzgerald University of Cambridge UKSession 1 Mutation clonal selectionChairs Jan Korbel EMBL Heidelberg GermanyAnna Poetsch TU Dresden Germany13 00 13 25Mechanisms and evolutionary trajectories of complex genome rearrangements in cancerIsidro Cortes Ciriano EMBL EBI UKLive stream only13 25 13 40Evolutionary dynamics of large scale DNA copy number alterations in patient derived adenoma organoidsThomas van Ravesteyn Hubrecht Institute The Netherlands13 40 13 55Selective pressures of platinum compounds shape the evolution of therapy related myeloid neoplasmsJurrian de Kanter Princess M xima Center for Pediatric Oncology and Oncode Institute The Netherlands13 55 14 20Reconstructing the embryology of childhood cancer from somatic mutationsSam Behjati Wellcome Sanger Institute UK14 20 14 35Accurate de novo detection of somatic mutations in single cell genomics and transcriptomics dataFrancesc Muyas EMBL EBI UK14 35 14 50Sperm sequencing reveals extensive positive selection in the human germlineMatthew Neville Wellcome Sanger Institute UKLive stream only14 50 15 05Single mitosis dissection of acute and chronic DNA mutagenesis and repairPaul Ginno German Cancer Research Center DKFZ Germany15 05 15 35Coffee break meet the speakers15 35 17 35Session 2 Cancer EvolutionChairs N ria L pez Bigas ICREA and Institute for Research in Biomedicine Barcelona IRB Barcelona SpainCraig Anderson MRC Institute of Genetics and Cancer UK15 35 16 00On the evolutionary history of metastatic cancerKamila Naxerova Harvard Medical School USA16 00 16 15The origin and evolution of pediatric secondary neoplasmsAbel Gonzalez Perez Institute for Research in Biomedicine Barcelona IRB Barcelona Spain16 15 16 40Darwinian epigenetic evolution and non Darwinian cellular plasticity in colorectal cancerAndrea Sottoriva Technopole Italy16 40 16 55Methylation dynamics in the decades preceding Acute Myeloid LeukaemiaAdriana Fonseca University of Cambridge UK16 55 17 10Inferring genomic trajectory of uveal melanomaChang Hyun Nam Korea Advanced Institute of Science and Technology Republic of Korea17 10 17 35Tumor evolution a real time and single cell perspectiveHugo Snippert University Medical Center Utrecht The NetherlandsLive stream only17 35 18 05Flash talks 57 Andersen Laura 61 Arnedo Pac Claudia 122 Lepp Aino Maija 135 McCullough Marcel 141 Nicholson Michael 143 Paassen Irene 149 Pham My 49 Poetsch Anna 151 Przybilla Moritz 163 Rueda Bertha 171 Selway Clarke Hugh 173 Sibai Mustafa 89 Supek Fran 59 Taylor Martin 187 Trinh Mi 195 von Berg Joanna 199 Wang Yichen 201 Wenger Anna 207 Yong Hanting18 05 19 35Poster session 1 odd numbers View poster listing here19 35 21 00Dinner in Canteen 21 00 22 30Drinks Networking Day 2 Thursday 16 November 2023 Time Europe Berlin SpeakerSession 3 Cancer Genome MedicineChair Young seok Ju Korea Advanced Institute of Science and technologyCarolin Sauer EMBL EBI UK09 15 09 40Convergence of machine learning and genomics for precision cancer medicineEliezer Van Allen Harvard Medical School USA09 40 09 55Saturation mutational scanning uncovers druggability of all FGFR kinase point mutationsCarla Schmidt University of Freiburg and German Cancer Consortium DKTK Germany09 55 10 20Understanding cancer biology through multi omics genotype phenotype tumour maps applications in rare cancersLynnette Fernandez Cuesta IARC FranceMatthieu Foll IARC France10 20 10 35Genomic analysis of skin cancers from Xeroderma Pigmentosum subgroups revealed new mechanisms of UV mutagenesisSergey Nikolaev Gustave Roussy Cancer Campus France10 35 11 00Coffee break meet the speakers11 00 11 25Genesis of uterine leiomyomas lessons from a benign neoplasmLauri Aaltonen University of Helsinki Finland11 25 11 40Somatic xeroderma pigmentosum group D XPD mutations alter local and global landscape of mutational processes in bladder cancerJayne Barbour The University of Hong Kong Hong Kong11 40 12 05The genomic and transcriptomic profile of melanoma in Latin American patientsCarla Daniela Robles Espinoza Universidad Nacional Aut noma de M xico Mexico12 05 13 30Meet the speakers and lunchSession 4 Emerging technologies in cancer genomicsChairs Isidro Cortes Ciriano EMBL EBI UKClaudia Arnedo Pac University of Cambridge UK13 30 13 55Clonal selection in normal tissues and its relation to cancer riskN ria L pez Bigas ICREA and Institute for Research in Biomedicine Barcelona IRB Barcelona Spain13 55 14 20Genomic landscapes of pre malignant lesions in stomach cancerPatrick Tan Duke NUS Medical School Singapore14 20 14 35Cancer patient derived organoids dependency mapCarmen Herranz Ors Wellcome Sanger Institute UK14 35 15 00Charting the regulatory landscape of tumors using single cell sequencing and spatial omicsOliver Stegle EMBL Heidelberg Germany15 00 15 15Single strand mismatch and damage patterns in cancer and cancer predisposition syndromes revealed by single molecule DNA sequencingGilad Evrony New York University Grossman School of Medicine USA15 15 16 10Coffee break meet the speakersSession 5 Genomic instability mutational processesChairs Martin Taylor University of Edinburgh UKAxel Rosendahl Huber Institute for Research in Biomedicine Barcelona IRB Barcelona Spain16 10 16 35Extrachromosomal DNA in cancerAnton Henssen Charit University Medicine Berlin Max Delbr ck Center for Molecular Medicine Germany16 35 17 00Chromothripsis in cancerAur lie Ernst German Cancer Research Center DKFZ Germany17 00 17 30Flash talks 52 Aitken Sarah 116 Kj r Asbj rn 130 M kinen Netta 134 McClellan Michael 136 McNamara Megan 148 Pensch Raphaela 150 Poon Yeuk Pin Gladys 160 Rodriguez Fos Elias 198 Wang Evan 176 Zavadil Jiri17 30 19 00Poster session 2 even numbers View poster listing here19 00 21 00Conference dinner21 00 00 00Live band The Chaotics ATC Foyer Day 3 Friday 17 November 2023 Time Europe Berlin SpeakerSession 5 continued Genomic instability mutational processesChairs Martin Taylor University of Edinburgh UKAxel Rosendahl Huber Institute for Research in Biomedicine Barcelona IRB Barcelona Spain09 00 09 25Exploring the role of retrotransposons in tumorigenesis antigenicity and genomic instabilityE Alice Lee Harvard University USA09 25 09 40Geographic variation of mutagenic exposures in kidney cancer genomesSarah Moody Wellcome Sanger Institute UK09 40 10 05Impact of chromatin architecture on somatic mutational processesSabarinathan Radhakrishnan National Centre for Biological Sciences India10 05 10 20CpG TpG mutagenesis DNA polymerase errors as a new culprit of an old crimeMarketa Tomkova University of Oxford UK10 20 10 50Coffee break meet the speakers10 50 11 15Forecasting oncogene amplicationGeoff Macintyre Spanish National Cancer Research Center CNIO Spain11 15 11 30Single cell evaluation of DNA damage in neonatal hematopoietic cells after prenatal exposure to chemotherapyIlana Struys KU Leuven Belgium11 30 11 45Mutation risk redistribution in cancer genomes linked to alterations in cell cycle genesMarina Salvadores Ferreiro Institute for Research in Biomedicine Barcelona IRB Barcelona SpainLive stream only11 45 12 00Mechanisms of APOBEC3 mutagenesis in human cancer cellsMia Petljak NYU Grossman School of Medicine USALive stream only12 00 13 00Meet the speakers and lunchSession 6 Cancer ecosystems microenvironmentChairs Sarah Aitken University of Cambridge UKMaria Andrianova Institute for Research in Biomedicine Spain13 00 13 25Widespread somatic L1 retrotransposition in normal colorectal epitheliumYoung Seok Ju Korea Advanced Institute of Science and Technology Republic of Korea13 25 13 40Homopolymer on off switches mediate adaptive mutability in mismatch repair deficient colorectal cancerMarnix Jansen UCL Cancer Institute UK13 40 14 05Insights into lung cancer evolution and metastases in TRACERx and PEACEMariam Jamal Hanjani UCL Cancer Institute UK This talk is now virtual 14 05 14 50Keynote lecture Deciphering cancer and aging usinghaplotype resolved single cell genomic sequencingJan Korbel EMBL Heidelberg GermanyLive stream only14 50 15 00Closing Remarks and Poster Prize15 30Departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 710On site PhD Student 610On site Industry 910Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact christopher stocks embl de for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Financial assistance Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Wednesday 18 November 2023 in some cases at special rates Please email the hotel directly quoting the booking code CAN23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergHotel Holl nder Hof Hotel Bayrischer Hof ISG Hotel Hotel MonptiB B HotelLeonardo Hotel Heidelberg City CentreStaycity Aparthotel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten Heidelberg Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings You can now find the conference bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions Where is the nearest Covid test centre Wo ist das n chste Covid Testzentrum HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Silver sponsor Bronze sponsor Event sponsor Active Motif BGI Genomics VectorBuilder VIZGEN Watchmaker Genomics Media partners Molecular Oncology a FEBS Press journal International Union of Biochemistry and Molecular Biology Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 Pre conference workshop For on site participants only This industry webinar will be hosted by our sponsor Scale Biosciences prior to the EMBL Conference Cancer genomics on Wednesday 15 November 2023 10 45 11 45 Participation in this workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served All registered conference attendees will receive an email with a registration link in the beginning of August ABSTRACT Single Cell Genomics at scale Unlock single cell workflows with combinatorial indexing Katharina DanielskiSenior Field Applications Specialist ScaleBio At ScaleBio we leverage the cell as the compartment to employ combinatorial indexing single cell profiling solutions This method enables increased levels of sample multiplexing increased cell throughput and support for a broad range of single cell genomics applications Numbers of cells or nuclei can be scaled exponentially to enable single cell experiments with 100s of thousands to millions of cells at a fraction of the cost of on market single cell isolation instruments In this workshop we will introduce you to the technology and outline our current kits which support scRNAseq scATACseq single cell methylation and CRISPR guide enrichment We will also discuss our data analysis pipeline and some relevant data examples...

Isidro Cortes Ciriano, Christina Curtis, Nuria Lopez-Bigas, Young Seok Ju

13 November - 17 November 2023

Hands-on flow cytometry: learning by doing!

Description OverviewSpeakers and trainersFinal programmePractical informationSponsorsMedia kit Overview Course overview Flow cytometry is a highly effective method for analysing individual cells that has become widely used in the fields of life sciences and medicine By utilising flow cytometry researchers can accurately identify and measure specific cell populations within complex mixtures as well as assess cell cycle progression proliferation status and expression of fluorescent markers Our course aims to provide a comprehensive understanding of the underlying principles of flow cytometry while also emphasising practical considerations related to the most frequently used assays Through a combination of theoretical instruction and hands on training students will gain the knowledge and skills necessary to effectively design execute and interpret flow cytometry experiments Audience The course is designed for researchers at any step of their career and will cover the subject from basic principles to complex assays Prior basic working knowledge of flow cytometry data acquisition or analysis software DIVA FlowJo is of advantage but not strictly a must Modules resources In depth principles of Flow Cytometry Quality assessment and instrument validation Analysis of cell cycle profiles in fixed cells Particles counting Apoptosis assays Tissue staining of cell surface and intracellular antigens Principles and guidelines for experimental design especially for multi colour Flow Cytometry Essential of gating and gating controls Detailed multi sessions on analysing data from Flow Cytometers in cooperation with FlowJo Guidelines to prepare flow cytometry data for publication Learning outcomes Our goal for this course is to teach the basic of this technology with a very big emphasis on practical work at the instruments Nothing is better than learning by doing We have a great set of experienced trainers in this technology delivering lectures and accompanying you into the lab doing flow on your own We will have support from FlowJo delivering the basics and some advanced features in multiple sessions This in depth five day course will push your knowledge and skills preparing you for any flow projects ahead on your research path What past participants say about the course My experience at EMBL was lovely and stimulating The knowledge I acquired through this short time has improved my learning and practical skills EMBL is a great place for scientific resources a friendly environment both socially and professionally Ibrahim Malami Usmanu Danfodiyo University Sokoto The course was excellently organized with high quality theoretical and practical sessions It is a must for everyone interested in basic and more specific aspects of flow cytometry techniques Filipe Olim University of Madeira I enjoyed the course a lot and learned what I was looking for an opportunity to learn the principles of flow cytometry that are important for planning and performing experiments Besides the theoretical part I was able to run samples at the instruments by myself which was a great starting point to perform experiments by myself in the future Maya Funk German Cancer Research Center Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers and trainers Speakers trainers and staff Jochen Barths ProSort France Michael Bonadonna EMBL Heidelberg Germany Daniel Gimenez EMBL Heidelberg Germany Gelo dela Cruz University of Copenhagen Denmark Marcus Eich German Cancer Research Center Germany Diana Ordonez EMBL Heidelberg Germany Ioannis Panetas FlowJo Informatics BD Germany Gerald Pfister EMBL Rome Italy Beata Ramasz EMBL Heidelberg Germany Steffen Schmitt German Cancer Research Center Germany Neda Tafrishi Sony Biotechnology Inc Germany Moritz Winker EMBL Heidelberg Germany Scientific organisers Daniel Gimenes EMBL Heidelberg Germany Diana Ordonez EMBL Heidelberg Germany Steffen Schmitt German Cancer Research Center Germany Course organisers Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Nathalie Sneider Course and Conference Manager EMBL Heidelberg Germany Final programme Are you on social media Post using EMBLCytometry and don t forget to tag EMBLEvents Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 13 November 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 30Welcome Introduction and Safety briefingATC Flex Lab09 30 10 45Participants flash talksATC Flex Lab10 45 11 15Coffee BreakATC Flex Lab11 15 12 00Lecture Fluidics and opticsGelo dela Cruz Novo Nordisk Foundation Center for Stem Cell Medicine reNEW DenmarkATC Flex Lab12 00 12 45Lecture Fluorescence and PMTs detectorsSteffen Schmitt German Cancer Research Center GermanyATC Flex Lab12 45 13 45LunchEMBL Canteen13 45 14 30Lecture Data generation and data displayGelo dela Cruz Novo Nordisk Foundation Center for Stem Cell Medicine reNEW DenmarkATC Flex Lab14 45 15 45Lecture The Essentials of gating FMO and gating controlsBeata Ramasz EMBL Heidelberg GermanyATC Flex Lab15 45 16 15Coffee BreakFlex Lab A B16 15 18 00Practical Session 1 Assessing instrument performanceTraining Lab B18 00 19 00DinnerEMBL Canteen19 00Departure to HotelATC Entrance Day 2 Tuesday 14 November 2023 Time Europe Berlin SessionLocation08 40 Bus from hotel to EMBL ATC Entrance09 00 10 00Lecture Fluorescence spillover and compensationGerald Pfister EMBL Heidelberg RomeATC Flex Lab10 00 10 30Coffee BreakATC Flex Lab10 30 12 00Practical Session 2 Absolute countingTraining Lab B12 00 13 00LunchEMBL Canteen13 00 14 00Lecture Experimental design for multi color flowDiana Ordonez EMBL Heidelberg Germany14 00 16 00Practical 3 Multi color staining Group 1 Practical 4 Data analysis with FlowJo Group 2 Group 1 Training Lab BGroup 2 Computer Training Lab16 00 16 30Coffee BreakATC Flex Lab16 30 18 30Practical 4 Data analysis with FlowJo Group 1 Practical 3 Multi color staining Group 2 Group 1 Computer Training LabGroup 2 Training Lab B18 30Departure to hotel19 00 21 30Offsite dinner Day 3 Wednesday 15 November 2023 Time Europe Berlin SessionLocation08 40 Bus from hotel to EMBL ATC Entrance09 00 09 30Q A sessionATC Flex Lab09 30 10 30Lecture Spectral Flow CytometryNeda Tafrishi Sony Biotechnology Inc GermanyATC Flex Lab10 30 11 00Coffee breakATC Flex Lab11 00 12 00Lecture Cell Cycle AnalysisDiana Ordonez EMBL Heidelberg GermanyATC Flex Lab12 00 13 00LunchEMBL Canteen13 00 15 00Practical 5 Cell cycle samples Group 1 Practical 6 Data analysis with FlowJo session 2 Group 2 Group 1 Training Lab BGroup 2 Computer Training Lab15 00 15 30Coffee breakATC Flex Lab15 30 17 30Practical 6 Data analysis with FlowJo session 2 Group 1 Practical 5 Cell cycle samples Group 2 Group 1 Computer Training LabGroup 2 Training Lab B17 30 18 30DinnerEMBL Canteen18 30Departure to hotel and free evening Day 4 Thursday 16 November 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC Entrance09 00 10 00Lecture Publishing your flow cytometry dataMarcus Eich German Cancer Research Center GermanyATC Flex Lab10 00 10 30Coffee BreakFlex Lab A B10 30 12 00Practical 7 Preparing Flow Data for Publication FlowJoComputer Training Lab12 00 13 00Lunch13 00 14 00Lecture Assessing cell deathSteffen Schmitt German Cancer Research Center GermanyATC Flex Lab14 00 15 30Practical 8 Measuring apoptosisTraining Lab B15 30 16 00Coffee BreakFlex Lab A B16 00 17 30Practical 9 Data acquisition Data AnalysisTraining Lab B Computer Training Lab17 45Departure to restaurantATC Entrance18 00 22 00Social Activity and Dinner Day 5 Friday 17 November 2023 Time Europe Berlin SessionLocation08 40Bus from hotel to EMBL ATC Entrance09 00 10 00Lecture Basics of cell sortingJochen Barths ProSort FranceATC Flex Lab10 00 10 30Coffee BreakFlex Lab A B10 30 12 30Practical 10 Cell sorting and reanalysis of sorted cellsTraining Lab A B12 30 13 30Lunch13 30 14 30Lecture High dimensional data analysis with FlowJoIoannis Panetas BD GermanyATC Flex Lab14 30 15 00Feedback and GoodbyeATC Flex Lab15 00 Departure to Heidelberg Train StationATC Entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 600PhD Student 600Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights Sunday 12 November to Friday 17 November 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code CYT23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event Partners Event Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Daniel Gimenes, Diana Ordonez, Steffen Schmitt

12 November - 14 November 2023

Protein Structure Determination in Industry 2023

Description Overview Overview 31st Protein Structure Determination in Industry PSDI meeting On behalf of the executive committee we are delighted to invite you to the 31st Protein Structure Determination in Industry Meeting which will be held at the Wellcome Genome Campus Hinxton Cambridge between November 12 14 2023 This year s PSDI meeting is organised jointly by EMBL EBI and GSK supported by Hg3 Conferences For the latest details on the Programme Abstracts Registration details Accommodation Exhibition Venue please visit the dedicated conference microsite If you have any queries regarding the upcoming PSDI 2023 Conference then please do not hesitate to contact Hg3 Conferences By email events hg3 co uk By phone 44 0 1423 529333...

8 November 2023

Exploring protein families and domains using InterPro

Description InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites using predictive models provided by 13 different databases This webinar will take you through the different ways to search the InterPro website and its API to identify protein families and domains We will explore different use cases including how to use the InterPro sequence search functionality to identify the protein family membership the different domains and potentially the protein function of unknown proteins We will also explain how InterPro can be used to identify new protein domains using AlphaFold structure predictions...

8 November - 11 November 2023

The mobile genome: genetic and physiological impacts of transposable elements

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety recommendations if attending the on site event Conference overview This conference assembles world leading experts from diverse fields including genomics epigenetics structural biology developmental biology immunology cancer biology and neurobiology to discuss the broad impacts of transposable elements TEs on organismal biology The meeting provides a venue for cross disciplinary discussions with the goal of catalysing inter disciplinary collaborations to address emerging questions in these scientific fields Although often disparaged as junk DNA it is now undeniable that TE activity has significantly shaped the structure and function of all genomes ranging from bacteria to humans TEs are major drivers of genetic diversity and contribute to human disease Remarkably TE derived sequences are also often co opted by the host to play important roles in gene expression early development immunity neuronal diversification and perhaps aging Session topics Genomics and evolution Transposon regulation Transposition mechanisms Physiological impacts I Physiological impacts II Speakers Keynote speakers John Moran University of Michigan USA Anne Ferguson Smith University of Cambridge UK Speakers Joan Barau Institute of Molecular Biology Germany Jef Boeke NYU Grossman School of Medicine USA Virtual speaker Miguel Branco Queen Mary University of London UK Alejandro Burga Institute of Molecular Biotechnology Austria Daniel Croll University of Neuch tel Switzerland Ang lique Deleris Institute of Integrative Biology of the Cell I2BC France Sandra Duharcourt Institut Jacques Monod France Geoff Faulkner The University of Queensland Australia Yukiko Yamashita Massachusetts Institute of Technology USA Cl ment Gilbert Universit Paris Saclay France Vera Gorbunova University of Rochester USA Virtual speaker Michael Imbeault University of Cambridge UK Johan Jakobsson Lund University Sweden Claudia K hler Max Planck Institute of Molecular Plant Physiology Germany Virtual speaker Eric Miska University of Cambridge UK Tomoichiro Miyoshi Kyoto University Japan Coleen Murphy Princeton University USA Virtual speaker Jos Penad s Imperial College London UK Joseph Peters Cornell University USA Femi Olorunniji Liverpool John Moores University UK Sandra Richardson Mater Research Institute Australia Martin Taylor Harvard Medical School USA Phillip Zamore UMass Chan Medical School USA Scientific organisers D borah Bourc his Institut Curie France Julius Brennecke Institute of Molecular Biotechnology Austria Jose L Garcia Perez The University of Edinburgh UK Virtual Susan Wessler University of California Riverside USA Virtual Conference organiser Diah Yulianti EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOMobileGenome For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 8 November 2023 Time Europe Berlin Speaker 11 00 12 45Registration and light lunchShuttle Bus schedule12 45 13 00Opening remarksScientific organisers D borah Bourc his Institute Curie France and Julius Brennecke Institute of Molecular Biotechnology Austria13 00 18 15Session 1 Genomics and evolutionChaired by Julius Fabian Brennecke Institute of Molecular Biotechnology AustriaMarianne Yoth Aarhus University France13 00 13 30Escapee L1s promote parvalbumin interneuron developmentGeoff Faulkner University of Queensland Australia13 30 13 45Evolution of gene regulation by species specific transposable elements in primatesMari Ohnuki Kyoto University Japan13 45 14 00Protein domains from multigene families recurrently associate with domains derived from transposable elements and virusesMiguel Vasconcelos Almeida University of Cambridge UK14 00 14 30A Devil s Bargain with TEs for crop pathogen adaptationDaniel Croll University of Neuchatel Switzerland14 30 15 00Locus resolution analysis of L1 regulation and retrotransposition potential in mouse embryonic developmentSandra Richardson Mater Institute Australia15 00 15 30The role of the Cer1 transposon in horizontal transfer of transgenerational memoryColeen Murphy Princeton University USAVirtual talk15 30 16 00Coffee break and Meet the speakers withGeoff Faulkner Daniel Croll and Sandra Richardson16 00 16 15Exploring the contribution of transposable elements to the evolution of salamander developmental and regenerative programsDiego Rodriguez Terrones Research Institute of Molecular Pathology Austria16 15 16 30The silent architects of yeast genomeAleksandras Konovalovas Vilnius University Life Sciences Centre Institute of Biosciences Lithuania16 30 16 45The transcriptional repertoire of transposable elements during mammalian preimplantation developmentMarlies Oomen Helmholtz Zentrum Munich GermanyNot available on demand16 45 17 15Horizontal transfer of transposable elements in animalsCl ment Gilbert Paris Saclay University France17 15 18 15Keynote speaker 1 The genetics of epigenetic variation at transposable elements Anne Ferguson Smith University of Cambridge UK18 15 19 45Dinner19 45 21 15Science pub quiz optional EMBL Canteen19 45 21 45After dinner drinks optional ATC Rooftop Lounge Day 2 Thursday 9 November 2023 Time Europe Berlin Speaker 09 00 20 00Session 2 Transposon regulationChaired by D borah Bourc his Institut Curie FranceJuliane Glaser Max Planck Institute for Molecular Genetics Germany09 00 09 30Architects of genomic harmony KRAB zinc finger proteins expand the domestication potential of mobile elementsMichael Imbeault University of Cambridge UK09 30 09 45Novel actors involved in chromatin associated TE control in embryonic stem cellsEmeline Roger Institut Curie FranceNot available on demand09 45 10 15H3K27me3 recruitment at Transposable Elements in ArabidopsisAng lique Deleris I2BC Gif sur Yvette France10 15 10 30Comprehensive investigation of de novo insertions in piRNA clusters reveals dual functions of Panoramix in the piRNA pathwayYicheng Luo California Institute of Technology USA10 30 11 00Coffee break and Meet the speakers withAnne Ferguson Smith and Michael Imbeault11 00 11 30Transposable elements drive hybrid incompatibility in plantsClaudia K hler Max Planck Institute of Molecular Plant Physiology GermanyVirtual talk11 30 12 00Regulation of TEs in the mammalian germlineJoan Barau IMB Mainz Germany12 00 12 15Young hot L1s in the human genome evade the host restriction factor TEX19Ricky Padilla Del Valle University of Washington USANot available on demand12 15 12 30Flash Talks 1 odd numbers 53 54 101 141 15312 30 14 00Lunch and Meet the speakers withJoan Barau14 00 16 00Poster session 1 odd numbers 16 00 16 30Catalytic and non catalytic functions of PRC2 in the control of transposable elements in ParameciumSandra Duharcourt Institut Jacques Monod France16 30 16 45Recurrent molecular adaptation revealed by systematic cross species protein interaction analyses of the Drosophila piRNA pathwaySebastian Riedelbauch Aarhus University Denmark16 45 17 00A direct protein protein interaction network of cytoplasmic Drosophila piRNA pathway factorsMandy Jeske Heidelberg University Germany17 00 17 30PiRNA mediated TE control in mammalsPhilip Zamore University of Massachusetts Medical School USA17 30 17 45A co opted retroviral capsid defines a rapidly evolving architectural protein family that binds to transposable elementsWayo Matsushima cole Polytechnique F d rale de Lausanne EPFL Switzerland17 45 18 00Flash Talks 2 even numbers 92 118 162 16418 00 18 30Coffee break and Meet the speakers withSandra Duharcourt and Philip Zamore 18 30 19 00Genetics of cheating of geneticsYukiko Yamashita MIT Cambridge USA19 00 19 30The role of L1 elements in promoting agingVera Gorbunova University of Rochester USAVirtual talk19 30 19 45Transposon silencing in duckweeds lessons from non model organismsArturo Mari Ordonez Gregor Mendel Institute of Molecular Plant Biology Austria19 45 20 00Structural and biochemical insights on the role of HUSH component MPP8 in transposon regulationYorgo Modis University of Cambridge UK20 00 21 30Dinner21 00 22 30After dinner drinks Day 3 Friday 10 November 2023 Time Europe Berlin Speaker 09 00 14 00Session 3 Transposition mechanismsChaired by Orsolya Barabas University of Geneva SwitzerlandTomoichiro Miyoshi RIKEN Japan09 00 09 30Redefining mobility in bacterial geneticsJose Penad s Imperial College London UK09 30 09 45Structure function analysis of mammalian tRNA derived SINEsEmily Koch University of Michigan USA09 45 10 15A network of interferon stimulated genes inhibits human LINE 1 retrotranspositionTomoichiro Miyoshi RIKEN Japan10 15 10 30Extrachromosomal circular DNA reveals helitron activity in wheatEtienne Bucher Agroscope Switzerland10 30 11 00Coffee break and Meet the speakers withYukiko Yamashita Jose Penad s and Tomoichiro Miyoshi11 00 11 30Regulation of site specific recombination by serine integrasesFemi Olorunniji Liverpool John Moores University UK11 30 11 45From retroelements to retroviruses the evolutionary plasticity of reverse transcribing RNA virusesHaoming Zhai University of Cambridge UK11 45 12 15Diversity of target selection systems with Tn7 like elements from CRISPR guided transposons to bacterial telomere elementsJoseph Peters Cornell University USA12 15 12 30The genetic and environmental basis of heritable transposition in Arabidopsis thalianaMireia Bueno Merino IPS2 Paris Saclay University France12 30 12 45Genomic integration of SARS CoV 2 sequences in virus infected and viral RNA transfected human cells and infection of bat iPS cells with virusRudolf Jaenisch Whitehead Institute USA12 45 14 00Lunch and Meet the speakers withFemi Olorunniji and Joseph Peters14 00 16 30Session 4 Physiological impactsChaired by John Moran University of Michigan USAStephanie Workman Mater Research Institute Australia14 00 14 30Structural analysis and inhibition of human LINE 1 ORF2 protein reveals novel adaptations and functionsMartin Taylor Harvard Medical School USA14 30 15 00Giant virus like transposons mediate widespread horizontal gene transfer in nematodesAlejandro Burga IMBA Austria15 00 15 30Coffee break and Meet the speakers withMartin Taylor and Alejandro Burga15 30 16 30Keynote speaker 2 Studies of a human retrotransposable elementJohn Moran University of Michigan Ann Arbor USA16 30 17 30Panel Discussion on emerging topics in TE biologyNot available on demand17 30 19 30Poster session 2 even numbers 19 30 21 00Conference dinner21 00 00 00Conference party Day 4 Saturday 11 November 2023 Time Europe Berlin Speaker 09 00 13 15 Session 4 Physiological impacts continued Chaired by John Moran University of Michigan USAStephanie Workman Mater Research Institute Australia 09 00 09 15Co opted endogenous retrovirus governed Pregnancy Specific Glycoprotein 9 PSG9 locus coordinates trophoblast differentiation in human placentationZsuzsanna Izsvak Max Delbr ck Center Germany09 15 09 45Species specific regulation of trophoblast gene expression by endogenous retroviruses Miguel Branco Queen Mary University of London UKNot available on demand09 45 10 00Helitron derived repeat structures regulate transgenerational inheritance in C elegansFaisal Alkhaldi King Abdullah University of Science and Technology KAUST Saudi Arabia10 00 10 30Transposable elements and human brain disordersJohan Jakobsson Lund University Sweden10 30 10 45Reverse transcriptase related genes at the intersection of environmental stress responsesIrina Arkhipova Marine Biological Laboratory USANot available on demand10 45 11 00Somatic LINE retrotransposition in motorneurons has functional consequencesThomas Widmann FIBAO Fundaci n de Investigaci n Biosanitaria GENYO Centre for Genomics and Oncological Research Spain11 00 11 30Coffee break and Meet the speakers withJohn Moran Miguel Branco Johan Jakobsson and Eric Miska11 30 11 45Retroviral like particles inducing cell death drive a limb developmental malformationJuliane Glaser Max Planck Institute for Molecular Genetics Germany11 45 12 15Great GEMMs reveal dramatic human phenotypes conferred by intronic retrotransposon insertionsJef Boeke NYU Grossman School of Medicine USAVirtual talkNot available on demand12 15 12 30The Drosophila retrotransposable element Copia regulates larval neuromuscular junction physiologyPeter M Angale University of Massachusetts Chan Medical School USA12 30 12 45Endogenous retroviruses wrestle with epigenetic surveillance to drive host pathophysiologyYejing Ge MD Anderson Cancer Center USANot available on demand12 45 13 15piRNA dynamics in mammalian genomesEric Miska University of Cambridge UK13 15 13 30Closing remarks13 30 14 00Packed lunch and departure14 00Shuttle bus to Frankfurt airport tickets 30 Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Diah Yulianti for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel Here are the shuttle bus times for this conference View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event hashtag as the password The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeTsch ssGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie geht s I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual Participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners EMBO reports an EMBO Press journal International Union of Biochemistry and Molecular Biology FEBS Open Bio a FEBS Press journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Déborah Bourc’his, Julius Brennecke, Jose L. Garcia-Perez, Susan Wessler

7 November 2023

Multiscale model of the different modes of invasion: a PhysiBoSS application

Description The tumour microenvironment encompasses many different cell types including cancer cells stromal cells immune cells and the extracellular matrix ECM that interact and collectively influence cancer progression and treatment outcomes Recently computational mathematical models have been proved efficient in testing hypotheses and giving insights about tumour microenvironment functionalities Among those hybrid multiscale models combine different techniques that simulate both inter and intra cellular interactions In this context we present a 3D model of cancer cell invasion aiming to study the different modes of cell migration through the extracellular matrix and to predict means to block it by considering spatial information molecules diffusion and intracellular regulation The model was constructed using PhysiBoSS a multiscale framework which combines agent based modelling and continuous time Markov processes applied on Boolean network models Our multiscale model successfully reproduces single and collective migration processes reported in published experiments on cell invasion These experiments include various aspects such as the role of p63 expression in regulating MT1 MMP the spatio temporal activation of SRC triggering collective migration and the influence of different collagen densities on invasion modes In silico experiments can be performed to suggest potential targets capable of inhibiting highly invasive tumour phenotypes About the speakerMarco Ruscone is a PhD student in the Computation Systems Biology of Cancer group at Institut Curie Paris He started his academic career in Turin Italy where he pursued his bachelor degree in Physics and master degree in Physics of Complex Systems for the Biology at Universit degli Studi di Torino Currently his work focuses on developing multiscale models of cancer using a mixed approach of agent based modelling and simulation on Boolean networks...

Marco Ruscone

7 November 2023

How to make your research open with Europe PMC

Description Europe PMC is an open global database of life science publications and preprints hosted by European Bioinformatics Institute EMBL EBI Europe PMC is endorsed and supported by a group of international science funders including Wellcome World Health Organisation European Research Council and many others as their repository of choice The Europe PMC funders expect research outputs arising from research they support to be made freely and readily available In this webinar we will explain how researchers can make their research open using Europe PMC and cover the benefits of including publications and preprints in Europe PMC for authors and readers We will provide guidance on open access policies of Europe PMC funders and demonstrate how to include research publications in Europe PMC and PubMed Central USA...

7 November - 9 November 2023

Managing a bioinformatics core facility

Description This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL EBI s service teams and from each other These facilities play an essential role in enabling research in the molecular life sciences The landscape is constantly evolving as new research tools emerge as experiments become increasingly data intensive and as their clients experimental researchers become more exposed to the power of data driven biology This course will allow participants to share experiences discuss challenges and solutions that they face and plan ways to cope with the ever changing demands raised by the molecular life science field It will include sessions to learn from bioinformatics service providers hear how others have tackled common problems and work together to design core services resource them and measure their impact A limited number or travel bursaries are available Please see the Additional information tab for conditions...

Juanita Riveros

6 November - 9 November 2023

Preparation of genomics libraries for an emerging next-gen sequencing platform

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This course will focus on the latest state of the art sequencing platform technology and novel library preparation protocols We will start with experimental design focusing on the hands on library preparation including best practices standards and potential pitfalls concluding with sequencing of libraries bioinformatic evaluation best practice For this purpose we will use for the first time ever in the settings of the practical course the cutting edge sequencing platform AVITI https www elementbiosciences com products aviti which was developed by Element Biosciences and is currently entering the next gen sequencing NGS field An evaluation of the technology in conjunction with the newly developed library preparation reagents by New England Biolabs NEB will be important for the scientific community and course participants to assist their decision if to adopt the new sequencing technology The course will cover a complete workflow such as library preparation and sequencing The course participants will also learn about its tips and tricks and will also use bioinformatics tools required for data processing quality control and initial data analysis Beside the practical exercises lectures and discussion sessions the course will offer the opportunity to learn more about transferring the knowledge gained during the course to the home institute of the participants as well as the implementation of this new technology into the environment of genomics core facilities During the course participants will prepare two types of NGS libraries gDNA Seq and mRNA Seq We offer the opportunity to provide a maximum of 2 samples Those samples must be shipped to Heidelberg prior to the course and must meet quality criteria of EMBL GeneCore Generated libraries will be used for shallow sequencing Audience This course is directed towards wet lab molecular biologists scientists and technicians who want to assess and use the AVITI technology A focus will be on applicants from member states and their genomics core facilities This audience can best disseminate the knowledge gained during the course and serve scientists at their home institutes Modules resources Presentation of the latest state of the art sequencing technology Element Biosciences the AVITI system Hands on training on genomic library preparation with upcoming state of the art reagents Setting up an AVITI sequencing run Basics in data handling and analysis Learning outcomes The NGS field is entering a new phase of sequencing platforms available to the community and for their various applications One crucial eplatform is the Aviti sytem by Element Bioscinces During the course its participants will be exposed to the cutting edge sequencing technology learn to apply novel NEBNext NGS library preparation reagents and protocols learn about the benefits and bottlenecks of different systems be provided with guidance on the implementation of sequencing technologies into the core facility environment What past participants say about this course I truly recommend this course to anyone interested in RNASeq We were pushed to go below the limits of RNA input to construct libraries and it was an exciting challenge The spirit of science go beyond our limits was present through all of the course The knowledge sharing environment with all the participants trainers and speakers made this one of the best courses I have ever attended Anna Sofia Varanda University of Aveiro Portugal Speakers Speakers trainers and staff Stefaan Derveaux VIB Nucleomics Core Belgium Lim De Swert VIB Nucleomics Core Belgium Max Fritsch New England Biolabs Inc UK Samina Kaufmann Agilent Technologies Germany Jonathan Landry EMBL Heidelberg Germany Chris Mason Weill Cornell Medicine USA Virtual Speaker Pingfang Liu New England Biolabs USA Chris Mason Weill Cornell Medicine USA Virtual Speaker Matthias Meister Agilent Technologies The Netherlands Mireia Osuna Lopez EMBL Heidelberg Germany Hilal Ozgur EMBL Heidelberg Germany Michael Petridis New England Biolabs Inc USA Jan Provaznik EMBL Heidelberg Germany Tobias Rausch EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg Germany Scientific organisers John Baeten Element Biosciences The Netherlands Vladimir Benes EMBL Heidelberg Germany Bj rn Textor New England Biolabs Germany Pingfang Liu New England Biolabs USA Laura Villacorta EMBL Heidelberg Germany Course organisers Luana Ribeiro EMBL Heidelberg Germany Catherine Casas EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLSeqLibPrep Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 6 November 2023 Time Europe Berlin SessionLocation12 40Bus from ISG Hotel to EMBLHotel Entrance13 15 13 30Welcome of participants registrationFlex Lab A B13 30 14 00EMBL introduction house notes and lab safetyVladimir Benes EMBL Heidelberg GermanyBjoern Textor New England Biolabs USA John Baeten Element Biosciences The Netherlands Laura Villacorta EMBL Heidelberg GermanyLuana Ribeiro EMBL Heidelberg GermanyIrena Provaznikova EMBL Heidelberg GermanyFlex Lab A B14 00 14 30Lecture 1 Get familiar with the lab and introduction into the NEBNext Ultra II FS DNA workflow for Element BiosciencesPingfang Liu New England Biolabs USAVladimir Benes EMBL Heidelberg GermanyFlex Lab A B14 30 14 45Practical session Fragmentation End PrepPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USA Lim de Swert VIB Nucleomics Core Belgium Hilal Ozgur EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg GermanyTraining Lab B14 45 16 00Icebreaking activity Introduction round each participant 2 slides Flex Lab A B16 00 17 45Practical session Adaptor ligation Cleanup of adaptor ligated DNA size selection of adaptor ligated DNA and setup enrichment PCRPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USA Lim de Swert VIB Nucleomics Core Belgium Hilal Ozgur EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg GermanyTraining Lab B17 45 18 30Lecture 2 NEBNext protocol discussion and performance on the Aviti systemPingfang Liu New England Biolabs USAVladimir Benes EMBL Heidelberg GermanyFlex Lab A B18 30 19 30Practical session Clean UpPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USA Lim de Swert VIB Nucleomics Core Belgium Hilal Ozgur EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg GermanyTraining Lab B19 30 20 30Dinner at EMBLEMBL Canteen20 30Departure to hotelEMBL Bus Stop Day 2 Tuesday 7 November 2023 Time Europe Berlin SessionLocation08 40Bus from ISG Hotel to EMBLHotel entrance09 00 09 10Overview of the dayFlex Lab A B09 10 10 00Lecture 3 The Aviti platform at the VIB Nucleomics Core from implementation to routine usage Stefaan Derveaux VIB Nucleomics BelgiumFlex Lab A B10 00 10 15Introduction into RNA library preparation protocolPingfang Liu New England Biolabs USAVladimir Benes EMBL Heidelberg GermanyFlex Lab A B10 15 12 30Practical session polyA First Second Strand SynthesisPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USALim de Swert VIB Nucleomics Core Belgium Laura Villacorta EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg GermanyTraining Lab B12 30 13 30LunchEMBL Canteen13 30 14 30Practical session cDNA continuesPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USALim de Swert VIB Nucleomics Core Belgium Laura Villacorta EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg GermanyTraining Lab B14 30 15 00Practical session Set Up of End Prep dA TailingPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USALim de Swert VIB Nucleomics Core Belgium Laura Villacorta EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg GermanyTraining Lab B15 00 16 30Practical session Ligation and Clean Up PCR Set UpPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USALim de Swert VIB Nucleomics Core Belgium Laura Villacorta EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg GermanyTraining Lab B16 30 17 30Lecture 4 Multi omic profiling methods for astronauts and spaceflight virtual Chris Mason Weill Cornell USAFlex Lab A B17 30 18 30Practical session Clean UpPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USAMax Fritsch New England Biolabs USALim de Swert VIB Nucleomics Core Belgium Laura Villacorta EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg GermanyTraining Lab B18 30 19 45Tips Tricks with concurrent Pizza DinnerATC Rooftop Lounge19 45Departure to HotelEMBL Bus Stop Day 3 Wednesday 8 November 2023 Time Europe Berlin SessionLocation08 40 Bus from ISG Hotel to EMBLHotel Entrance09 00 09 10Overview of the dayFlex Lab A B09 10 10 00Practical session Library QCPingfang Liu New England Biolabs USAMichael Petridis New England Biolabs USA Max Fritsch New England Biolabs USA Lim de Swert VIB Nucleomics Core Belgium Hilal Ozgur EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg GermanyTraining Lab B10 00 11 00Lecture 5 Library QC A perspective from Agilent TechnologiesSamina Kaufmann Agilent Technologies GermanyFlex Lab A B11 00 12 30Lecture 6 Aviti System by Element Biosciences John Baeten Element Biosciences The NetherlandsFlex Lab A B12 30 13 15LunchEMBL Canteen13 15 13 30Group Photo13 30 15 00Set up of the Aviti Sequencer Tour through GeneCore FacilityJohn Baeten Element Biosciences The NetherlandsVladimir Benes EMBL Heidelberg GermanyGeneCore Facility15 00 15 30Coffee Break15 30 17 00Lecture 7 Considerations on experimental design and NGS implementation the Core FacilityVladimir Benes EMBL Heidelberg GermanyFlex Lab A B17 00Bus Heidelberg downtown and sightseeingATC Entrance19 30Dinner Networking NEB sponsored Oskar Vinothek and Restaurant Day 4 Thursday 9 November 2023 Time Europe Berlin SessionLocation08 40 Bus from ISG Hotel to EMBL Hotel Entrance09 00 09 10Overview of the dayComputer Training Lab09 10 10 00Practical Lecture Introduction to NGS Data formats and QC Jan Provaznik EMBL Heidelberg GermanyJonathan Landry EMBL Heidelberg GermanyComputer Training Lab10 00 10 30Coffee break10 30 12 00Practical Lecture Review Generated Raw Data Element Cloud Solution John Beaten Element Biosciences The NetherlandsComputer Training Lab12 00 13 00Lunch EMBL Canteen13 00 14 30Practical session Light Intro to Genome Mapping Variant Calling Jan Provaznik EMBL Heidelberg GermanyJonathan Landry EMBL Heidelberg GermanyTobias Rausch EMBL Heidelberg GermanyComputer Training Lab14 30 15 00Feedback round and closing remarksFlex Lab A B15 30Bus to Heidelberg train station and city centerEMBL Bus Stop Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration fees include admission course materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia575 PhD Student575 Industry1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights 5 10 November 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code NEB23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants 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de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 x 9...

John Baeten, Vladimir Benes, Björn Textor, Pingfang Liu, Laura Villacorta

6 November - 10 November 2023

Solution scattering from biological macromolecules

Description OverviewSpeakersVirtual programme 6 10 November 2023 On site programme 27 Nov 1 December 2023 Practical informationSponsorsMedia kit Overview Course overview This course consists of two parts a virtual module and an on site module The series of online lectures will take place from 6 10 November 2023 In addition to this a small number of selected students that have completed the virtual module will be offered to take part in the practical component of this course that will take place in Hamburg from 27 November 1 December 2023 We encourage advanced PhD students postdocs and junior researchers to apply The virtual module lectures will cover the basics of SAXS SANS instrumentation data collection modelling techniques and complementary use with other methods The students are also encouraged to sign up for a self paced practical tutorial that covers basic and advanced SAXS data processing steps including quizzes to keep track of successful participation In the on site module there will be 2 tracks offered focusing on different aspects of SAXS data collection Applicants will be able to select a preferred track during motivation letter submission Students that are not taking part in the on site module will be able to sign up for small online discussion groups These discussion groups will be led by one of the course speakers tutors and you will be given the chance to discuss your own data SAXS experiments with your peers Audience The course is aimed at young biochemists biophysicists and researchers active in related structural methods with little or no experience in solution scattering The virtual module is aimed at early career scientists interested in expanding their knowledge in SAXS On site track 1 X ray beamline operation is aimed at advanced pre docs early stage postdocs interested in working with synchrotron radiation and technical aspects of scattering experiments During the practical you will learn different steps for commissioning and calibrating a beamline how to streamline workflows and what to consider for data collection and management On site track 2 sample preparation and optimization for SAXS is aimed at pre doctoral and postdoctoral fellows with a background and or an interest in biochemistry In this track we will be looking at best practices in sample preparation and data collection as well as various tools for data quality assessment Students are encouraged to bring their own samples Modules resources SAXS data collection Data processing Basic analysis Novel SAXS data analysis methods Integrative structural biology Reporting and quality assessment Learning outcomes During the virtual module of the course we will take a look at all essential steps of SAXS data analysis from applying for beamtime collecting processing and analysing SAXS data as well as proper reporting and quality assessment At the on site module deeper insights into beamline operation or optimization of measurements can be gained Speakers Speakers and tutors Pau Bernado University of Montpellier France Stefano DaVela Bremerhaven University of Applied Sciences Germany Kristina Djinovi Carugo EMBL Grenoble France Stefan Fiedler EMBL Hamburg Germany Frank Gabel IBS Grenoble France Maria Garcia Alai EMBL Hamburg Germany Richard Gillilan Cornell University USA Tobias Gr wert BIOSAXS GmbH Germany Cy Jeffries EMBL Hamburg Germany Al Kikhney Xenocs Grenoble France Annette Langkilde University of Copenhagen Denmark Anne Martel ILL Grenoble France Dima Molodenskiy EMBL Hamburg Germany Sylvian Prevost ILL Grenoble France Zehra Sayers Sabanc niversitesi Turkey Martin Schroer University of Duisburg Essen Germany Dmytro Soloviov EMBL Hamburg Germany Dmitri Svergun EMBL Hamburg Germany Jill Trewhella University of Sydney Australia Charlotte Uetrecht University of Siegen Germany Scientific organizers Clement Blanchet EMBL Hamburg Germany Melissa Gr wert EMBL Hamburg Germany Virtual programme 6 10 November 2023 Day 0 Thursday 2 November 2023 TimeSpeaker14 00 15 00Onboarding Day 1 Monday 6 November 2023 Time Europe Berlin Speaker14 00 14 10WelcomeMelissa Gr wert EMBL Hamburg Germany14 10 15 10Lecture SAXS TheoryRichard Gillian Chess University Cornell USA15 10 16 10Lecture SAXS and SANSFrank Gabel IBS Grenoble France16 10 16 30Coffee Break16 30 17 30Lecture SAXS InstrumentationClement Blanchet EMBL Hamburg Germany17 30 18 15SPECIAL P12 virtual beamline tour optional OngoingStudent Presentation Wall show us your SAXS project mini video or poster Day 2 Tuesday 7 November 2023 Time Europe Berlin Speaker14 00 14 10WelcomeClement Blanchet EMBL Hamburg Germany14 10 15 10Lecture SAXS samplesMelissa Gr wert EMBL Hamburg Germany15 10 16 10Lecture Practical SAXS basic analysisAl Kikhney Xenocs Grenoble France16 10 16 30Break16 30 17 30Tutorial Introduction to self paced programMelissa Gr wert EMBL Hamburg Germany17 30 18 15SPECIAL Meet former students optional OngoingStudent Presentation Wall show us your SAXS project mini video or poster Day 3 Wednesday 8 November 2023 Time Europe Berlin Speaker14 00 14 10Overview of the dayMelissa Gr wert EMBL Hamburg Germany14 10 15 10Lecture SAXS hybrid modellingCy Jeffries EMBL Hamburg Germany15 10 16 10Lecture SAXS AI based modelsDima Molodenskiy EMBL Hamburg Germany16 10 16 30Break16 30 17 30Lecture SAXS flexible systemsPau Bernado EMBL Hamburg Germany17 30 18 15Optional Q A to self paced studyMelissa Gr wert EMBL Hamburg GermanyOngoingStudent Presentation Wall show us your SAXS project mini video or poster Day 4 Thursday 9 November 2023 Time Europe Berlin Speaker14 00 14 10Overview of the dayClement Blanchet EMBL Hamburg Germany14 10 14 50Lecture SAXS Integrated Structural BiologyKristina Djinovic EMBL Grenoble France14 50 15 30Lecture SAXS Fibrillation StudiesAnnette Langkilde University of Copenhagen Denmark15 30 16 10Lecture SAXS Studies on VirusesCharlotte Utrecht HPI Hamburg Germany16 10 16 30Break16 30 17 30Keynote Lecture SAXS for IndustryDmitri Svergun BIOSAXS GmbH Germany17 30 18 15Optional Q A to self paced studyMelissa Gr wert EMBL Hamburg GermanyOngoingShow us your results post a quick feed back on the progress of your data analysis Day 5 Friday 10 November 2023 Time Europe Berlin Speaker14 00 14 10Overview of the dayMelissa Gr wert EMBL Hamburg Germany14 10 15 10Lecture SAXS Beyond ProteinsMartin Schroer University of Duisburg Essen Germany15 10 16 10Lecture SAXS StandardsJill Trewhella University of Sydney Australia16 10 16 30Break16 30 16 50Tutoria SASBDB for SAXSCy Jeffries EMBL Hamburg Germany16 50 17 30Course wrap upNext Steps prize ceremonyOngoingShow us your results post a quick feed back on the progress of your data analysis On site programme 27 Nov 1 December 2023 Got something to say Tweet it EMBLSolutionScattering Some pre course work such as watching pre recordings protocol reading and computational exercises will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change All times in the programme below are shown as the time in Europe Berlin Day 1 Monday 27 November 2023 Time Europe Berlin SpeakerLocation10 00 11 00Welcome and course overviewClement Blanchet EMBL Hamburg GermanyMelissa Gr wert EMBL Hamburg GermanySeminar Room11 00 12 30Facility TourClement Blanchet EMBL Hamburg GermanyMelissa Gr wert EMBL Hamburg GermanyPetra III12 30 13 30LunchCoffee Room13 30 16 30Practical 1A 1B1A Hardware overview Data collection stratgies1B Measurement strategies Sample preparation I P12Seminar room User Lab SPC16 30 17 00BreakCoffee Room17 00 18 30Student presentationsSeminar Room18 30 19 00Q ACoffee Room19 00 20 30DinnerCoffee Room Day 2 Tuesday 28 November 2023 Time Europe Berlin SpeakerLocation09 30 12 30Practical 2A 2B2A Commissioning Calibration2B Sample preparation I Buffer preparationP12Seminar room User Lab SPC12 30 13 30LunchCoffee Room13 30 14 00Track ExchangeStudents provide updates to each otherSeminar room14 00 17 00Practical 3A 3B3A Pipelines for data collection strategies VC SANS instrumentation3B Data collectionP12Seminar room User Lab SPC17 00 17 30BreakCoffee Room17 30 19 00Buffer Time data collection data analysis sample prepP12 seminar room SPC19 00 20 30DinnerCoffee Room Day 3 Wednesday 29 November 2023 Time Europe Berlin SpeakerLocation09 30 11 30Practical 4A 4B4A Optical components Stefan Fiedler 4B Data quality assessmentP12Seminar room11 30 12 30Special tutorial SAXS and AlfafoldSeminar room12 30 13 30LunchCoffee room13 30 14 30Buffer Time data collection data analysis sample prepP12 seminar room SPC14 30 15 00Departureside entrance15 00 18 00EXCURSION VISIT the EuXFELEuXFEL18 00 18 30DepartureXFEL main gate18 30 20 30Course dinnert b d Day 4 Thursday 30 November 2023 Time Europe Berlin SpeakerLocation09 30 12 30Practical 7A 7B5A Specialized sample environments5B Preparation of non protein samples Stefano DaVela Organizing Beamtime Trips Annette Langkilde P12User Lab SPC12 30 13 30LunchCoffee Room13 30 14 30TIPPS TRICKS Session beamtime application samples for industry beyond solution SAXS advanced SAXS analysisSeminar room14 30 17 30Practical 6A 6B6A Pipelines for data analysisVC Working with lab sources Al Kikhney Soren Skou 6B Data collection AF4 SAXSP12Seminar room User Lab SPC17 30 18 00BreakCoffee Room18 00 19 00Special Lecture Dmitri SvergunSeminar room19 00 21 00Dinnerwith Meet GreetCoffee Room Day 5 Friday 1 December 2023 Time Europe Berlin SpeakerLocation09 30 12 30Buffer Time data collection data analysis sample characterizationP12User Lab SPC12 30 13 30LunchCoffee Room13 30 14 00Last reminder Reporting beamline settings data quality Beamline accessSeminar room14 00 14 45Special Lecture Zehra SayersSeminar room14 45 15 15Course Wrap UpSeminar room15 15 15 45departureCoffee Room Practical information Registration fees and motivation letter The number of participants will be limited to 60 virtual participants and 10 participants for the on site module When applying for this course you will have the possibility to apply for only the virtual module or for both virtual and on site modules Please note that only students that have completed the virtual module will be taken into consideration in the selection for an on site module Registration Registration fees for the virtual module include access to online lectures and other course materials Academia 75PhD Student 75Industry 250 Registration fees for the on site module include accommodation in single rooms at the DESY guesthouse all meals throughout the duration of the course and course materials Travel expenses are NOT covered with the registration fee Academia 400PhD Student 400Industry 1000 Please note that students selected for the on site module will have their virtual module registration fee waived and will only have to pay the on site registration fee A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For more detailed information follow the instructions provided in our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Limited financial assistance in the form of both registration fee waivers for virtual module and travel grants for the on site module is available for this course You will be able to apply for the financial assistance during the motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and transport Reservations for single room accommodation at the DESY hostel have been made Note accommodation is included in the registration fee The guest house is within a few minutes walk from the EMBL laboratories and P12 beamline Further information Address EMBL Hamburg Notkestra e 85 Buliding 48e 22607 Hamburg GermanyFrom Hamburg airport take line S1 to Othmarschen 18 stops 45 min change to bus number 1 towards Rissen or Schenefelder Holt to Zum H nengrab DESY 5 stops 10 min From Hamburg Altona train station take bus number 1 to Zum H nengrab DESY 15 stops 25 min Ticket costs Public Transport ca 3 60 and a taxi will be around 45 Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus At the mandatory on boarding session on Thursday 2 November the functionalities of the platform and course content will be further explained Technical requirements Information will be provided for installation of the newest ATSAS package in advance This will be needed to accomplish the SAXS Quest that will be offered in parallel to the SAXS virtual module COVID 19 related questions Updated information will be provided closer to the time of the on site module Sponsors Sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsoring embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Melissa Gräwert, Clement Blanchet

1 November 2023

Exploring protein sequences and functional annotations with UniProt

Description UniProt provides the scientific community with a comprehensive high quality and freely accessible resource of protein sequence and functional information This webinar will guide you through ways in which students and researchers at all career stages may take a structured approach to access the data in the UniProt KnowledgeBase UniProtKB section of the UniProt protein function database We will discuss the types of protein data that can be accessed and using sequence analysis tools how this data can be analysed to answer biological questions We will demonstrate how to find the function of a protein how the protein components of a pathway may be identified features of proteins of interest can be compared similar sections of sequence can be sought in other species and how whole data sets containing all the proteins expressed in an organism can be obtained By accessing sequence structural and functional data through UniProt we want researchers to be part of a journey through biology and support further work and adventures along the way...

25 October - 27 October 2023

Proteomics in cell biology and disease mechanisms

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPre conference workshop Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Even after a few decades of great accomplishments the field of proteomics remains to develop further fueled by continued technological and computational advances in high throughput methods and multi omics big data integration The Proteomics in cell biology and disease mechanisms conference will provide attendees with a program that provides the current state of affairs in proteomics including a future perspective It will be held at a pioneering hot spot for proteomics in Europe in association with EMBL in Heidelberg Germany This year s programme will focus on the latest technological advances with a focus on medical and clinical applications of proteomics as well as fundamental and mechanistic aspects of cell biology including intra and inter cellular communication through interactions and post translational modifications This is a cross disciplinary meeting that will bring together proteomics technology experts of all ages from academia and industry life science specialists and medical communities who are interested in systems biology cell signalling as well as disease and clinical proteomics EMBL Heidelberg will be hosting the final event of this very successful series that has been alternating between Heidelberg Germany and Wellcome Genome Campus UK Session topics Cellular communication and interactions Proteomics technologies Hot now single cells and spatial proteomics Proteomics for precision medicine Computational proteomics and data analysis What past participants say about the conference I really enjoyed the EMBL Wellcome Genome Campus Conference Proteomics in Cell Biology and Disease Mechanisms It was an exciting and very stimulating opportunity for me and it gave me the opportunity to network and establish novel collaborations I look forward to participating in the next edition Giovanni Cuda M D Department of Experimental and Clinical Medicine University of Magna Graecia Medical School Catanzaro Italy An excellent conference great for networking and the exchange of knowledge perfectly organised in the beautiful city of Heidelberg Dina Schuster Department of Analytical Chemistry Faculty of Chemistry Vienna Austria Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speakers Nevan Krogan University of California San Francisco USA Paola Picotti ETH Z rich Switzerland Speakers David Baker University of Washington USA Virtual speaker Marcus Bantscheff Cellzome Germany Yu Ju Chen Academia Sinica Taiwan Vadim Demichev Charit Germany Rong Fan Yale University USA Tami Geiger Weizmann Institute of Science Israel Albert Heck Utrecht University The Netherlands Marco Hein Max Perutz Labs Medical University of Vienna Austria Ruth Huttenhain Stanford University School of Medicine USA Matthias Mann Max Planck Institute of Biochemistry Germany Jesper V Olsen University of Copenhagen Denmark Maria Tanzer Walter and Eliza Hall Institute Australia Namrata Udeshi Broad Institute USA Mathias Uhl n SciLifeLab Sweden Jing Yang National Center for Protein Sciences China Scientific organisers Yu Ju Chen Institute of Chemistry Academia Sinica Taiwan Ileana Cristea Princeton University USA Albert Heck Utrecht University The Netherlands Matthias Mann Max Planck Institute of Biochemistry Germany Conference organiser Catherine Casas Course and Conference Officer EMBL Heidelberg Germany Programme Are you on social media Post using EWCSProteomics and don t forget to tag EMBLEvents Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk Recorded talks will be accessible on demand for 2 weeks after the end of the event Programme is preliminary and subject to change Day 1 Wednesday 25 October Time Europe Berlin Session11 00 12 30 Registration and light refreshments11 15 12 15 Pre conference workshop Protein Interaction Coupling PICO A Novel Platform Technology for Ultra sensitive Detection and Quantification of Proteins Protein Interactions and PTMs by ACTOME registration required 12 30 12 45Opening remarks12 45 13 30Keynote speaker Using systems approaches to understand mechanisms in diseaseNevan Krogan University of California San Francisco USANot available on demandSession 1 Cellular communication and interactionsChair Marco Hein Max Perutz Labs Medical University of Vienna Austria13 30 13 55A proteomic perspective on the removal of dying cellsMaria Tanzer Walter and Eliza Hall Institute Australia13 55 14 10Mapping genetic determinants of phosphorylation identifies upstream signalling regulators Elise Needham University of Cambridge United Kingdom14 10 14 25Intercellular communication within a virus microenvironment dictates cellular resistance to secondary infections in a proximity dependent mannerJames Kostas Princeton University United States of America14 25 14 50Flash talksPoster numbers 37 Aljohara Alotaibi39 Miguel Rosado41 Christian Blum43 Lucia Buccioli45 German Rosano47 Joel Christie49 Francesca Conte51 Miguel Cosenza Contreras55 Matthias Fahrner57 Joris Frenz59 Biplab Ghosh61 Christian Gnann65 Nisha Hemandhar Kumar67 Shelley Jager71 Sonja Kabatnik73 Hasmik Keshishian75 Bianca Kuhn77 Ming Tong81 Nadja Gebert14 50 15 20Coffee Break15 20 15 45Next generation pan cancer blood proteome profiling using proximity extension assay and mass spectrometryMathias Uhl n SciLifeLab Sweden virtual speaker 15 45 16 00Phosphoprotein dynamics of interacting tumor and T cells by HySicKelly Stecker Utrecht University The Netherlands16 00 16 15Structural systems biology by crosslinking mass spectrometry and deep learningAndrea Graziadei Fondazione Human Technopole Italy16 15 16 40Mapping the diversity in spatiotemporal regulation of G protein coupled receptorsRuth Huttenhain Stanford University School of Medicine USA16 40 17 05Flash talksPoster numbers 83 Giorgia Massacci85 Andreas Metousis87 Ivan Mikicic89 Sophia M ller Dott91 Marie Neu93 Denys Oliinyk97 Stefan Ebner99 Benjamin Raymond101 Hendrik Weisser103 Valeriia Sapozhnikova105 Felix Schneidmadel107 Adrianna Seredynska111 Sophia Steigerwald113 Pranay Talla115 Marvin Thielert121 Katharina Waury125 Marius Wrona17 05 18 35Poster session 1 odd numbers with refreshments18 35 20 05Dinner in Canteen20 05 21 35Social event Day 2 Thursday 26 October Time Europe Berlin Session Session 2 Proteomics technologiesChair Ruth Huttenhain Stanford University School of Medicine USA09 00 09 25Narrow window DIA for ultra fast quantitative analysis of comprehensive proteomes with high sequencing depthJesper V Olsen University of Copenhagen Denmark09 25 09 40A nongenetic optochemical method for proximity labeling in the live mouse brain Mikiko Takato Kyoto University Japan09 40 09 55Deep quantitative glycoproteomics reveals gut microbiome induced remodeling of the brain glycoproteomeCl ment Potel EMBL Heidelberg Germany09 55 10 25Coffee Break10 25 10 50Mapping nanoscale proteome landscape and beyond by highly streamlined microfluidics based strategyYu Ju Chen Academia Sinica Taiwan10 50 11 05Advances in sensitive high throughput single shot HLA I and HLA II immunopeptidomicsSteven Carr Broad Institute of MIT and Harvard United States of America11 05 11 20Hydrogel based tissue transformation methods for spatially resolved untargeted proteomicsKiryl Piatkevich Westlake University China11 20 11 45Advances in subcellular and cell surface proteomics using proximity and chemical labeling approachesNamrata Udeshi Broad Institute USA11 45 13 15Meet the speakers and LunchSession 3 Hot now Single cells and spatial proteomicsChair Vadim Demichev Charit Germany13 15 13 40Spatially resolved proteogenomic profiling via deterministic barcoding in tissueRong Fan Yale USA13 40 13 55Single cell proteomics and transcriptomics of the human hematopoietic stem and progenitor hierarchy enables modelling of protein expression dynamicsBenjamin Furtw ngler Copenhagen University Denmark13 55 14 10Spatial proteomics reveals regional proteomic heterogeneity in the mouse brain upon circadian disruptionFrederike Sch fer Ludwig Maximilians Universit t M nchen Germany14 10 14 55Coffee Break14 55 15 20Design of new protein functions using deep learning David Baker University of Washington USA pre recorded talk 15 20 15 35Pooled multicolor tagging for visualizing subcellular proteome dynamicsAndreas Reicher CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Austria15 35 16 00Spatial proteomics with single cell resolution to study functional heterogeneity in tumor tissuesMatthias Mann Max Planck Institute of Biochemistry Germany16 00Free evening Day 3 Friday 27 October Time Europe Berlin Session Session 4 Proteomics for precision medicineChair Namrata Udeshi Broad Institute USA09 00 09 25Immunoglobulins the not to be ignored proteins in the plasma proteomeAlbert Heck Utrecht University the Netherlands09 25 09 40New proteomics approach to identify tissue leakage proteins in liquid biopsiesEsperanza Fernandez VIB University of Ghent Belgium09 40 09 55Systemic analysis of the pathological effects of a snake venom and of the impact of antivenom in a murine model of envenomingSolange Maria de Toledo Serrano Butantan Institute Brazil09 55 10 25Coffee Break10 25 10 50Proteomic analysis of cancer internal heterogeneityTami Geiger Weizmann Institute of Science Israel10 50 11 05Revealing the commonalities of monomeric and polymeric IgA1 clonal repertoires from human serum and milk with LC MS methodsAmber Rolland Utrecht University The Netherlands11 05 11 20Plasma immunopeptidomic profiling by ultra high sensitive mass spectrometryMaria Wahle Max Planck Institute of Biochemistry Germany11 20 11 45Phamacoproteomic profiling identifies secreted markers for aberrant drug actionMarcus Bantscheff Cellzome Heidelberg Germany11 45 12 10Flash talksPoster numbers 36 Rim Abderrahim38 Constantin Ammar40 Franziska Traube42 Susanne Breitkopf44 Mira Burtscher48 Emilio Cirri50 Miguel Cosenza Contreras52 Alexandra Davies54 Katrin Stuber56 Tobias Feilen58 Vijayalakshmi Gangadhara60 Ursula Glocker62 Nawal Hajj Sleiman64 Jennifer Heck66 Ericka Itang68 Agnete Jensen70 Anette Johansen72 Sabita Kawan74 Hasan Basri Kilic76 Shibojyoti Lahiri78 Mujia Li12 10 13 40Meet the speakers and LunchSession 5 Computational proteomics and data analysisChair Maria Tanzer Walter and Eliza Hall Institute Australia13 40 14 05Fast and sensitive DIA proteomics and its applicationsVadim Demichev Charit Germany14 05 14 20Tapioca an ensemble machine learning framework for studying global protein protein interaction network dynamics identifies NUCKS1 as a pan herpesvirus proviral factor Tavis Reed Princeton University United States of America14 20 14 35Hierarchical Gaussian process models uncover the dark meltome of thermal proteome profiling experimentsCecile Le Sueur EMBL Heidelberg Germany14 35 15 05Coffee Break15 05 15 30Democractizing proteomics for chemistsJing Yang National Center for Protein Sciences China15 30 15 45Enhancing network methods for the systematic analysis of signaling from phosphoproteomics dataMartin Garrido Rodriguez EMBL Heidelberg and Heidelberg University Germany15 45 16 10Systematic immuno capture of native organelles defines a spatial map of the human proteomeMarco Hein Max Perutz Labs Medical University of Vienna Austria16 10 16 35Flash talksPoster numbers 80 Maximilian Maldacker82 Barbara Kracher86 Alina Meyer90 Johannes Bruno M ller Reif92 Kendra Njo94 Dimitris Papagiannidis95 Iwan Parfentev96 Kuan Chih Peng98 Sandra Pihlstr m100 Alicia Reyes104 Julia Schessner106 Luisa Schwarzm ller108 Tatiana Shamorkina110 Bachuki Shashikadze112 Oliver Schilling114 Neil Taylor116 Annika Topitsch122 Caroline Weiss124 Tilman Werner126 Maximilian Zwiebel16 35 18 05Poster session 2 even numbers with refreshments18 05 18 50Keynote speaker Decoding the protein dancePaola Picotti ETH Zurich SwitzerlandNot available on demand18 50 19 05Closing Remarks and Poster Prize19 05 20 35Conference dinner20 35 22 35Conference Party Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 710On site PhD Student 610On site Industry 910Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Catherine Casas for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact Catherine Casas for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Wednesday 27 September 2023 in some cases at special rates Please email the hotel directly quoting the booking code PRO23 02 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions Where is the nearest Covid test centre Wo ist das n chste Covid Testzentrum HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Where is the nearest COVID 19 test centre Wo ist das n chste COVID 19 Testzentrum Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Silver sponsor Bronze sponsor Event sponsorCell Research Media partners Disease Models Mechanisms The Company of Biologists Journal FEBS Journal a FEBS Press journal International Union of Biochemistry and Molecular Biology Journal of Cell Science a The Company of Biologists journal Molecular Systems Biology an EMBO Press journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 x 90 Pre conference workshop For on site participants only This pre conference workshop will be hosted by our sponsor ACTOME GmbH prior to the EMBL Wellcome Connecting Science Conference Proteomics in cell biology and disease mechanisms on Wednesday 25 October 2023 11 15 12 15 Participation in this workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served All registered conference attendees will receive an email with a registration link soon ABSTRACT Protein Interaction Coupling PICO A Novel Platform Technology for Ultra sensitive Detection and Quantification of Proteins Protein Interactions and PTMs Tam s Sz r di Marius Pollet and Csaba JeneyActome GmbH Freiburg Germany The Protein Interaction Coupling PICO technology is a novel ultra sensitive immunoassay for the detection and absolute quantification of native proteins protein interactions and post translational modifications PTMs PICO combines the advantages of immunoassays with digital PCR technology by employing DNA labeled antibodies The PICO workflow involves labeling of antibodies with unique DNA oligonucleotides PICO Labels the lysis of the biological sample the mixing and incubation of the lysed sample with the DNA labeled antibodies the amplification and readout with QIAGEN s QIAcuity dPCR System and the data analysis with AMULATOR Actome s web based analysis software PICO has a broad range of applications in basic research biomarker and drug discovery and is particularly useful for studying low abundance proteins and transient interactions In addition PICO enables the absolute quantification of proteins without the need of an external standard With its unparalleled sensitivity and absolute quantitative feature PICO is poised to transform the field of protein analysis and quantification and enables detailed insight into biological signal transduction...

Yu-Ju Chen, Ileana Cristea, Albert Heck, Matthias Mann

23 October - 27 October 2023

Systems biology: from large datasets to biological insight

Description This course covers the use of computational tools to extract biological insight from omics datasets The content will explore a range of approaches ranging from network inference and data integration to machine learning and logic modelling that can be used to extract biological insights from varied data types Together these techniques will provide participants with a useful toolkit for designing new strategies to extract relevant information and understanding from large scale biological data The motivation for running this course is a result of advances in computer science and high performance computing that have led to groundbreaking developments in systems biology model inference With the comparable increase of publicly available large scale biological data the challenge now lies in interpreting them in a biologically valuable manner Likewise machine learning approaches are making a significant impact in our analysis of large omics datasets and the extraction of useful biological knowledge Additional information Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic...

Jane Reynolds

22 October - 27 October 2023

FISHing for RNAs: classical to single molecule approaches

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Over the past decades it became evident that the specific amount and localisation of an RNA transcript are important to understand the biological function of its non coding gene Whereby state of the art in situ hybridisation ISH technologies are key to visualise these RNAs in a given tissue or cell This course will teach participants to apply three powerful RNA visualisation techniques all in histological tissue samples conventional in situ hybridisation ISH hybridisation chain reaction ISH HCR ISH and the cutting edge single molecule fluorescent ISH smFISH In addition essential tissues embedding protocols adapted to facilitate visual interrogation of RNA transcripts will also be covered Benefit from our excellent trainer to participant ratio for personalised training in addition to world class research facilities and networking opportunities with leading experts in the field Audience This course is targeted to early stage scientists PhD and postdocs across the field of molecular biology with an interest in application of these techniques for their research Onboarding day This hybrid course will begin on 6 October 2023 with a joint onboarding session for on site and virtual participants where access to pre course study materials exercises and pre recorded lectures will be provided through an introduction to our collaboration platform EMBL eCampus This will prepare the participants for the course start on 22 October 2023 Full time attendance is required for both virtual and on site components of this course Information on the live stream and access to the virtual course platform will be provided shortly before the start of the event and will be available for 2 weeks after the course Lectures All lectures will be delivered on site and live streamed to all virtual participants via Zoom Please see the preliminary programme for details on all lectures On site practicals These are the practicals for the course all of the content will be delivered on site in the training laboratories and the microscopy rooms at EMBL The practicals will not be live streamed to virtual participants please see below for the virtual practical information which will take place in tandem to the on site practicals Practical session 1 Introduction and theory of conventional ISH Practical session 2 Probe preparation ddUTP dye conjugation Practical 3a and 3b Introduction and theory smFISH and HCR Practical 4 Imaging in groups smFISH and HCR ISH Practical session 5 Basics ISH image analysis Virtual practicals The content of the virtual practicals will be delivered in the form of interactive protocols as well as video tutorials recorded by the trainers The following content will be available for virtual participants during the above on site practical sessions Please see the preliminary programme for when these will take place Overview of the complete workflow smFISH probe design 40 min video Material HCR split initiator design 45 min video Material Dye conjugation of amino 11 ddUTP 12 min video material Probe labelling for smFISH 30 min video Material smFISH and HCR 30 min video material Image analysis 60 min video material The interactive protocol will cover NcRNA or microRNA in situ hybridisation on paraffin sections of mouse tissues We will also include Q A sessions with trainers to give participants the opportunity to ask questions about the procedures of the material given Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Monica Ballarino University of Rome La Sapienza Italy Marie Laure Baudet University of Trento Italy Dr Florence Besse University of Nice Institut de Biologie Valrose iBV France Mainak Bose EMBL Heidelberg Germany Chiara Capponi University of Rome La Sapienza Italy Jeffrey A Chao Friedrich Miescher Institute for Biomedical Research Switzerland Marina Chekulaeva Max Delbr ck Center for Molecular Medicine Germany Eleonora D Ambra Center for Life Nano Neuro Science of Istituto Italiano di Tecnologia IIT Italy Sara Di Persio M nster University Hospital Germany Michael Feldbruegge Institute of Microbiology Heinrich Heine University Germany Imre Gaspar Turbine ai Hungary Johanna Gassler Max Planck Institute of Biochemistry Germany Elizabeth Gavis Princeton University USA Aissam Ikmi EMBL Heidelberg Germany Ralf Jungmann Max Planck Institute of Biochemistry Germany Emerald Perlas EMBL Rome Italy Tiziana Santini University of Rome La Sapienza Italy Tim Weil University of Cambridge UK Scientific organisers Monica Ballarino University of Rome La Sapienza Italy Imre Gaspar Turbine ai Hungary Emerald Perlas EMBL Rome Italy Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Please note This programme is preliminary at the moment and is subject to change Got something to say Tweet it EMBOFISHingRNAs Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Friday 6 October 2023 Time Europe Berlin ProgrammeMilestones of the dayMilestones of the day How to use eCampus Explain milestones How to follow the workflow How to use the protocol How to use the resources VMs Watch pre recorded lectures by Sunday 22nd October 2023 the start of the course eCampus lectures 1 2 3 13 00 13 20Welcome virtual onboarding13 20 13 40Practical parts Online Protocols13 40 14 40Ice breaker14 40 15 00Wrap up Day 1 Sunday 22 October 2023 Time Europe Berlin Onsite ProgrammeVirtual ProgrammeMilestones of the dayMilestones of the day None13 45 14 00Bus from ISG hotel to EMBLLog on and check connection14 00 14 30Welcome and house notes and course overviewWelcome and house notes and course overview14 30 16 30Ice breaking activity Flash talks and activity in groupswith concurrent coffee breakIce breaking activity Flash talks and activity in groups16 30 17 15Keynote Lecture 1 Applying RNA imaging methodologies to tackle ncRNAs in brain Marie Laure Baudet University of Trento ItalyKeynote Lecture 1 Applying RNA imaging methodologies to tackle ncRNAs in brain Marie Laure Baudet University of Trento Italy17 15 18 00Keynote Lecture 2 Transcriptional profiling of spermatogenesis in human and issues in infertility Sara Di Persio M nster University Hospital GermanyKeynote Lecture 2 Transcriptional profiling of spermatogenesis in human and issues in infertility Sara Di Persio M nster University Hospital Germany18 00 18 45Comfort breakComfort break18 00 21 00Moderated discussion rounds with concurrent dinner in the canteenModerated discussion rounds The onsite participants will also eat during the time please feel free to do this too 18 45 19 30Discussion to Prerecorded LECTURE 1 Topic Histology overview and applicationsModerated by Emerald Perlas EMBL Rome ItalyDiscussion to Prerecorded LECTURE 1 Topic Histology overview and applicationsModerated by Emerald Perlas EMBL Rome Italy19 30 20 15Discussion to Prerecorded LECTURE 2 Topic RNA detection methodsModerated by Imre Gaspar Turbine ai HungaryDiscussion to Prerecorded LECTURE 2 Topic RNA detection methodsModerated by Imre Gaspar Turbine ai Hungary20 15 21 00Discussion to Prerecorded LECTURE 3 Topic ncRNA Charme in cardiac and skeletal muscleModerated by Monica Ballarino University of Rome La Sapienza ItalyDiscussion to Prerecorded LECTURE 3 Topic ncRNA Charme in cardiac and skeletal muscleModerated by Monica Ballarino University of Rome La Sapienza Italy21 00 21 15Wrap upWrap up21 15Departure to Hotel Day 2 Monday 23 October 2023 Time Europe Berlin Onsite ProgrammeOnsite locationVirtual ProgrammeMilestones of the dayMilestones of the day Practical 1 Introduction and Preparation for practical e g buffer prepPractical 1 Protocol steps 1 5Practical 2 Protocol and Video Dye conjugation of amino 11 ddUTP 12 min 08 30 09 00Arrival and coffee09 00 09 10Overview of the dayFlex labsOverview of the day09 10 09 30Lab safety instructions Flex labsLab safety instructions 9 30 10 45Interactive lecture demo Specimen section preparationEmerald Perlas EMBL Rome ItalyTraining Lab A BLIVESTREAM PRACTICAL Interactive lecture demo Specimen section preparationEmerald Perlas EMBL Rome Italy10 45 11 00Coffee breakFlex labsEmerald continues and gives intro to conventional ISH for virtual participants Imre gives an overview too11 00 11 45Keynote Lecture 7 Neuronal sorting of RNA Marina Chekulaeva Max Delbr ck Center for Molecular Medicine GermanyFlex labsKeynote Lecture 7 Neuronal sorting of RNA Marina Chekulaeva Max Delbr ck Center for Molecular Medicine Germany11 45 12 30Keynote Lecture 4 Interplay between genetic and environmental factors in shaping body plans Aissam Ikmi EMBL Heidelberg GermanyFlex labsKeynote Lecture 4 Interplay between genetic and environmental factors in shaping body plans Aissam Ikmi EMBL Heidelberg Germany12 30 13 30Lunch breakEMBL Canteen13 30 14 15Practical session 1 Introduction and theory of conventional ISH Protocol Overview Emerald Perlas assisted by Chiara Capponi Sara Di Persio and Tiziana SantiniTraining Lab A B14 15 14 45Practical session 2 Probe preparation ddUTP dye conjugation Imre Gaspar assisted by 3 helpersTraining Lab A B14 45 16 45Practical session 1 Conventional ISH section pre treatment Proteinase K digest acetylation hybridization set up Emerald Perlas assisted by Chiara Capponi Sara Di Persio and Tiziana SantiniTraining Lab A B16 45 17 00Coffee breakFlex labs17 00 17 45Keynote Lecture 5 Phase separation in RNA localization Mainak Bose EMBL Heidelberg GermanyFlex labsKeynote Lecture 5 Phase separation in RNA localization Mainak Bose EMBL Heidelberg Germany17 45 18 00Comfort break18 00 19 30DinnerEMBL Canteen19 30 21 30Student presentations 10 student presentations each 5 min presentation plus 6 min discussion Flex labsStudent presentations 10 student presentations each 5 min presentation plus 6 min discussion 21 40Departure to HotelATC Entrance Day 3 Tuesday 24 October 2023 Time Europe Berlin Onsite ProgrammeVirtual ProgrammeMilestones of the dayMilestones of the day Practical 3a and 3b Video smFISH probe design part1 part 2 part3 36 min Video HCR design part1 part2 43 min OPTIONAL Preparation of buffers for lab Protocol steps probe labelling for smFISH Video probe labelling smFsFISH part 1 part 2 part 3 22 min Video sm FISH and HCR ISH specimen pre work and hybridisation set up 8 min Practical 1 Protocol steps 6 end08 30 09 00Arrival and coffee09 00 09 10Overview of the day09 10 10 15Practical session 1 conventional ISH post hybridisation washesEmerald Perlas assisted by Chiara Capponi Sara Di Persio and Tiziana Santini10 15 11 00Keynote Lecture 3 RNP granule dynamicsFlorence Besse University of Nice Institut de Biologie Valrose iBV FranceKeynote Lecture 3 RNP granule dynamicsFlorence Besse University of Nice Institut de Biologie Valrose iBV France11 00 11 15Coffee break11 15 12 00Practical session 1 Conventional ISH staining set upEmerald Perlas assisted by Chiara Capponi Sara Di Persio and Tiziana Santini12 00 13 00Lunch at EMBL canteen13 00 13 30Practical session 2 Theory and demo of probe designImre Gaspar assisted by 3 helpersLIVESTREAM PRACTICAL Practical session 2 Theory and demo of probe designImre Gaspar assisted by 3 helpers13 30 14 30Practical 3a and 3b Introduction and theory smFISH and HCRMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana SantiniLIVESTREAM PRACTICAL Practical 3a and 3b Introduction and theory smFISH and HCRMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana Santini14 30 15 00Coffee break15 00 16 00Practical session 1 Conventional ISH washing and mounting of specimenEmerald Perlas assisted by Chiara Capponi Sara Di Persio and Tiziana Santini16 00 16 30Practical 3a and 3b sm FISH and HCR ISH specimen pre work and hybridisation set upMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana Santini16 30 17 00Practical 3a sm FISH Probe labeling set upMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana SantiniON incubation sm labeling 17 00 18 00Practical 3a and 3b continued HCR ISH specimen pre work and hybridisation set upMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana Santini18 00 19 00Dinner at EMBL19 00 21 1011 student presentation each 5 min presentation plus 6 min discussion 11 student presentation each 5 min presentation plus 6 min discussion 21 15Departure to Hotel Day 4 Wednesday 25 October 2023 Time Europe Berlin Onsite ProgrammeVirtual ProgrammeMilestonesMilestones of the day Practical 3a and 3b Protocol parts smFISH in myotubes and HCR Video smFISH and HCR generics part 1 part2 23 min Video Mounting 08 30 09 00Arrival and coffee09 00 09 10Overview of the day09 10 11 30Practical 3a and 3b smFISH Probe purifications and measurementsHCR ISH washessmFISH pre hybridisation set up for incubationHCR ISH Amplification set up for reactionsmFISH hybridisationMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana SantiniWith concurrent coffee break11 30 12 15Keynote Lecture 8 Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila developmentTim Weil University of Cambridge UKKeynote Lecture 8 Adaptable P body physical states differentially regulate bicoid mRNA storage during early Drosophila developmentTim Weil University of Cambridge UK12 15 13 15Lunch break at EMBL canteen13 15 15 45Practical session 1 Conventional ISH imagingEmerald Perlas assisted by Chiara Capponi Sara Di Persio and Tiziana SantiniWith concurrent coffee breakLIVESTREAM Practical with Emerald and Trainers15 45 16 30Keynote Lecture 9 Membrane associated RNA transportMichael Feldbruegge Institute of Microbiology Heinrich Heine University GermanyKeynote Lecture 9 Membrane associated RNA transportMichael Feldbruegge Institute of Microbiology Heinrich Heine University Germany16 30 18 00Practical 3a and 3b smFISH HCR ISH washes and specimen mountingMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana SantiniWith concurrent coffee break18 00 19 00Dinner at EMBL19 00 20 30DISCUSSION ROUND responsible conduct of research Experimental designStandards and controls in the ISH fieldDISCUSSION ROUND responsible conduct of research Experimental designStandards and controls in the ISH field20 40Departure to Hotel Day 5 Thursday 26 October 2023 Time Europe Berlin Onsite ProgrammeVirtual ProgrammeMilestones of the dayMilestones of the day Prepare for discussion rounds with Emerald Monica and co 08 30 09 00Arrival and coffee09 00 09 10Overview of the day09 10 10 30Practical 4 Imaging in groups smFISH and HCR ISH Monica Ballarino Imre Gaspar Eleonora D Ambra Tiziana Santini10 30 10 45Coffee break and group photoGroup photo Please take a screen shot of yourselves on Zoom we will add this to the group photo 10 45 12 15Practical 4 Imaging in groups smFISH and HCR ISH Monica Ballarino Imre Gaspar Eleonora D Ambra Tiziana SantiniMeet the speaker for the virtual participants12 15 13 15Lunch at EMBL canteen table set up based on next career steps13 15 14 00Keynote Lecture 10 RNP assembly for transport and translational controlElizabeth Gavis Princeton University USAKeynote Lecture 10 RNP assembly for transport and translational controlElizabeth Gavis Princeton University USA14 00 14 45Keynote Lecture 6 Dynamics of localized translation of mRNAJeffrey Chao Friedrich Miescher Institute for Biomedical Research SwitzerlandKeynote Lecture 6 Dynamics of localized translation of mRNAJeffrey Chao Friedrich Miescher Institute for Biomedical Research Switzerland14 45 16 15Meet the speakers for the on site participantsLIVESTREAM Practical 4 Imaging smFISH and HCR ISH with Imre Gaspar16 15 16 30Coffee breakCoffee break16 30 17 15Keynote Lecture 11 PAINT superresolution imaging of nucleic acidsRalf Jungmann Max Planck Institute of Biochemistry GermanyKeynote Lecture 11 PAINT superresolution imaging of nucleic acidsRalf Jungmann Max Planck Institute of Biochemistry Germany17 30 18 00Bus to Heidelberg18 00 19 30Heidelberg Guided City tour19 30 22 30Dinner at Kulturbrauerei in downtown Heidelberg Day 6 Friday 27 October 2023 Time Europe Berlin Onsite ProgrammeVirtual ProgrammeMilestones of the dayMilestones of the day None08 30 09 0009 00 10 00Discussion on Practical 4 Summary of Image taking including best practices and standardsMonica Ballarino Imre Gaspar Eleonora D Ambra Tiziana Santini10 00 10 30Coffee break 10 30 11 50Practical session 5 Basics ISH image analysisImre Gaspar assisted by 3 helpersLIVESTREAM Practical 5 Basics ISH image analysiswith Imre Gaspar11 50 13 20Practical session 5 ISH image analysis incl standards in the field Imre Gaspar assisted by 3 helpersLIVESTREAM Practical 5 ISH image analysiswith Imre Gaspar13 20 14 20Lunch at EMBL canteen14 20 15 20Group work Participants preparing group presentationssupported by trainers with concurrent coffee breakVirtual participants welcome to join but no virtual presentation possible15 20 16 20Discussion Group Data Presentations incl Discussions with concurrent coffee breakDiscussion Group Data Presentations incl Discussions16 20 17 20Wrap upWrap up17 45Bus to Heidelberg train station and city center Post course day Friday 3rd November 2023 Time Europe Berlin Onsite ProgrammeVirtual Programme13 00 15 00Postcourse day Virtual session Open discussion round on questions to practicals first questions will be collected via EMBL eCampus All main trainersPostcourse day Virtual session Open discussion round on questions to practicals first questions will be collected via EMBL eCampus All main trainers Practical information Registration fees and motivation letter The course is limited to 16 onsite participants and 5 virtual For selection purposes please note that your application will not be considered without a letter of motivation Registration On site registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Virtual registration fees include access to live streamed course content lectures Q A sessions with speakers and trainers discussion rounds as well as virtual learning activities in the learning platform On site Academia 500On site PhD Student 500On site Industry 1200Virtual Academia 190Virtual PhD Student 190Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which 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Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset childcare costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of Sunday 22 October to Friday 27 October 2023 5 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 24 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details 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Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partner Event sponsor Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com 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Monica Ballarino, Imre Gaspar, Emerald Perlas, Elisabeth Zielonka

18 October 2023

Finding and interpreting protein structure and function data using PDBe-KB

Description Proteins are the workhorses of the cell responsible for most biological functions Though we can group related proteins through sequence similarity it is the 3 dimensional structure of these proteins that determines the functions of these molecules of life Therefore knowledge of protein structure and its relation to additional biological context can help us create a more complete understanding of how a protein works PDBe KB https pdbe kb org is an open collaborative data resource which aims to support the access and integration of structural biology data helping users to easily generate biological insights The Aggregated Views of Proteins provided through PDBe KB provide a unique way to display all the relevant structure and function data for a specific protein in one place This allows us to determine trends across these structures including common binding and interaction sites and identification of different conformations of the protein This webinar will give an introduction to the PDBe KB Aggregated Views of Proteins and how they can be used to access and interpret structure and function data...

18 October - 21 October 2023

Organoids: modelling organ development and disease in 3D culture

Description OverviewSpeakersProgrammePractical informatonSponsorsAboutMedia kitPre conference workshops Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview The ability to grow human tissues from stem cells in 3D culture has the potential to revolutionise the drug discovery process and regenerative medicine Building on a long tradition of cell and developmental biology knowledge organoids resembling a variety of human tissues have been generated This conference will bring together the leading researchers in this field to establish a new research community and reveal parallels between various tissue models The aim of this meeting is to bring together researchers from different fields to enhance our understanding of how organoids can be formed and maintained how they can be used to study disease and how we might eventually use them to regenerate and replace human organ tissue Session topics Concepts from development and evolution Building organoid complexity Organoids from adult stem cells Organoids in regenerative medicine therapy Organoids in disease modeling What past participants say about the symposium Organoid biology is all about interaction across multiple disciplines and methods TheEMBO EMBL Symposium has been a wonderful venue for hosting such cross talks Francesco Cambuli Columbia University USA This conference was a great oppotunity to bring together experts on the organoid field creating an important network for future collaborations Veronica Foletto University of Trento Italy This symposium was one of the best conferences I attended so far Beside the location and networking possibilities I would like to emphasize the great choice of speakers and posters The presented data and new applications were astonishing and represented the development of organoid field very nicely Thank you very much for the organization of such a great symposium Thomas D ullary Julius Maximilians Universit t of W rzburg Germany Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speaker Melissa Little Murdoch Children s Research Institute Australia Magdalena Zernicka Goetz University of Cambridge and California Institute of Technology UK and USA Speakers Cantas Alev Remote speaker Kyoto University Japan Gray Camp University of Basel Switzerland Silvia Cappello Max Planck Institute of Psychiatry Germany Hans Clevers F Hoffmann La Roche Ltd Switzerland Switzerland Penney Gilbert University of Toronto Canada Anne Grapin Botton Max Planck Institute of Molecular Cell Biology and Genetics Germany Muzlifah Haniffa Newcastle University and Wellcome Sanger Institute UK Kim Bak Jensen University of Copenhagen Denmark J rgen Knoblich Institute of Molecular Biotechnology IMBA Austria Joo Hyeon Lee University of Cambridge UK Sasha Mendjan Institute of Molecular Biotechnology Austria Christine Mummery Leiden University The Netherlands Josef Penninger Helmholtz Centre for Infection Research Germany Anne Rios Princess M xima Center The Netherlands Jason Spence University of Michigan USA Takanori Takebe Cincinnati Children s Hospital Medical Center USA Sara Wickstr m Max Planck Institute for Molecular Biomedicine Germany Scientific organisers Meritxell Huch Max Planck Institute of Molecular Cell Biology and Genetics Germany Karl R Koehler Boston Children s Hospital and Harvard Medical School USA Madeline Lancaster MRC Laboratory of Molecular Biology UK Esther Schnapp EMBO Press Germany Conference organiser Lea Hohmann EMBL Heidelberg Germany Programme Got something to say Tweet it EESOrgan Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk and the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 18 October 2023 Time Europe Berlin Speaker14 00 16 00Registration and light refreshments14 30 15 30Pre conference workshops withAmsbio Carl ZEISS Evident STEMCELL TakaraBioMore information will be shared closer to the conference16 00 16 15Opening remarks by Esther Schnapp16 15 18 50Session 1 Concepts from development and evolutionSession Chair Madeleine Lancester MRC Laboratory of Molecular Biology Cambridge UK16 15 16 40Charting human development with organoid single cell technologiesGray Camp University of Basel SwitzerlandNot available on demand16 40 16 55The emergence of actin stars for epithelium coordination and tissue patterningAmlan Barai Institut de Biologie du D veloppement de Marseille IBDM CNRS Aix Marseille University FranceNot available on demand16 55 17 10Morphogen stepwise temporal gradient driven neural induction shapes brain organoid development into a single expanded neuroepithelium with enhanced cortical identityAnna Pagliaro Prinses Maxima Centrum The NetherlandsNot available on demand17 10 17 40Coffee Break and Meet the speakers17 40 18 05Human iPSC Intestine Mimetics co differentiated with Mesenchymal Endothelial and Enteric Nervous TissueJason Spence University of Michigan USANot available on demand18 05 18 20Modulation of human placental development by uterine Natural Killer cells new insights using trophoblast organoidsElisa Magistrati Friedrich Miescher Institute for Biomedical Research SwitzerlandNot available on demand18 20 18 35Multimodal signal integration for tissue scale decision makingCornelia Schwayer Friedrich Miescher Institute for Biomedical Research SwitzerlandNot available on demand18 35 18 50Cell type tracking in intestinal organoids reveals commit then sort differentiation modelSander Tans AMOLF institute The Netherlands18 50 19 35Keynote Lecture Extending what we know about kidney organoids to deliver on disease modelling and tissue engineeringMelissa Little Murdoch Children s Research Institute Australia19 35 21 05Dinner in Canteen21 05 23 00After dinner drinks Day 2 Thursday 19 October 2023 Time Europe Berlin Speaker09 00 12 05Session 1 Concepts from development and evolution cont Session Chair Meritxell Huch Max Planck Institute of Molecular Cell Biology and Genetics Germany09 00 09 25Decoding the developing human immune systemMuzlifah Haniffa Newcastle University and Wellcome Sanger Institute UK09 25 09 40Human Pluripotent Stem Cells Derived Inner Ear Organoids Recapitulate Otic Development In Vitro Marta Roccio University Hospital Zurich SwitzerlandNot available on demand09 40 09 55Fueling Cellular Transformation Insulin s Dynamic Role in Generating Airway and Alveolar Lung Organoids from Endodermal NKX2 1 Cells Mirian Romitti Universit libre de Bruxelles ULB Belgium09 55 10 25Coffee Break and Meet the speakers10 25 10 50Organoids to probe infectionsJosef Penninger Helmholtz Centre for Infection Research Germany10 50 11 05Recapitulation of human early embryonic development in artificial micro environments from notochord to gastrula Zhe Wang Kyoto University Japan11 05 11 20Spatial and temporal regulation of cell cell fusion in human placentaVeronica Farmer Duke University USA11 20 12 05Keynote Lecture To be presented on siteMagdalena Zernicka Goetz California Institute of Technology USANot available on demand12 05 13 30Lunch13 30 16 25Session 2 Building organoid complexitySession Chair Kim Bak Jensen University of Copenhagen Denmark13 30 13 55Self organization in pancreas organoids formation of complex ductal networksAnne Grapin Botton Max Planck Institute of Molecular Cell Biology and Genetics GermanyNot available on demand13 55 14 10Complex intestinal organoid models to study immune epithelial interactions Joana F Neves King s College London United Kingdom14 10 14 35Overcoming challenges of brain organoids to uncover what it means to be pluripotent Madeline Lancaster MRC Cambridge UK14 35 15 05Coffee Break and Meet the speakers15 05 15 30Reconstituting human axial development with axioloidsCantas Alev Kyoto University JapanNot available on demand remote talk15 30 15 45Differentiating stem cells one at a time in 3D reveals how the dynamical build up of local microniches controls tissue organisation in gastruloids and bile duct organoids Virgile Viasnoff National University of Singapore Singapore15 45 16 00Design and control of in vitro microenvironments with simple CUBE device to achieve organoid architecture Masaya Hagiwara RIKEN Japan16 00 16 25Multi chamber cardioids unravel human heart development and cardiac defectsSasha Mendjan Institute of Molecular Biotechnology Austria16 25 16 45Flash talks 52 Reconstructing the development of fetal insulinproducing enteroendocrine cellsAkkerman Ninouk 74 Light dependent modulation of microRNA expression in human retinal organoidsCeliker Canan 91 Developing an immunocompetent in vitro 3D brain model of alzheimer s disease to study the neuroprotective effects of estrogenDemetriou Aphrodite 112 Supracellular contractility of fibroblasts in homeostasis injury and wound healingGlisovic Neda 181 Ex utero cell derived model of the human post implantation embryo developmentBondarenko Vladyslav 183 Microfluidics driven tissue patterning of neural organoidsPark JiSoo 219 Local tissue mechanics controls homeostatic livecell extrusion in the small intestineSpoelstra Willem Kasper 243 Communication of cellular fitness in intestinal organoidsvan Luyk Merel 245 Bacterial infection of intestinal organoidsvon Peinen Kristin16 45 18 45Poster Session 1 odd with beer and snacksView poster listing here18 45Free evening Day 3 Friday 20 October 2023 Time Europe Berlin Speaker09 00 12 00Session 3 Organoids from adult stem cellsSession Chair Penney Gilbert University of Toronto Canada09 00 09 25Organoids to model human diseaseHans Clevers F Hoffmann La Roche Ltd SwitzerlandNot available on demand09 25 09 40PIEZO dependent mechano sensing of the niche is essential for intestinal stem cell fate decision and maintenance Meryem B Baghdadi Institut Curie France09 40 09 55Multilineage liver organoids recapitulate aspects of the liver peri portal region and faithfully model cholestatic liver diseaseAleksandra Sljukic Max Planck Institute of Molecular Cell Biology and Genetics MPI CBG GermanyNot available on demand09 55 10 25Coffee Break and Meet the speakers10 25 10 40Intestinal organoid and organ on chip models to recapitulate celiac disease pathophysiology Sebo Withoff University Medical Center Groningen The NetherlandsRemote speaker10 40 10 55Host response to Pseudomonas aeruginosa and Staphylococcus aureus in an ex vivo human airway model of cystic fibrosisPawan Parajuli Commonwealth Scientific and Industrial Research Organisation CSIRO Australia10 55 11 20Regulation of stem cell dynamics through niche derived signals and forcesSara Wickstr m Max Planck Institute for Molecular Biomedicine GermanyNot available on demand11 20 11 45Esther Schnapp Editor Talk Transparent Publishing at EMBO Press11 45 13 30Lunch13 30 16 25Session 4 Organoids in regenerative medicine therapySession Chair Anne Grapin Botton Max Planck Institute of Molecular Cell Biology and Genetics Germany13 30 13 55Understanding interconnectedness in liver development and diseaseTakanori Takebe Cincinnati Children s Hospital Medical Center USA Not available on demand13 55 14 10Golgi organization is a determinant of stem cell function in the small intestine Sandra Scharaw Karolinska Institutet SwedenNot available on demand14 10 14 35Skin organoids for developmental modeling and therapyKarl Koehler Boston Children s Hospital and Harvard Medical School USANot available on demand14 35 15 05Coffee Break and Meet the editors and Meet the speakers15 05 15 30In silico predictions coupled with the mini IDLE predictive assay identifies myofiber derived biomolecules dictating muscle stem cell return to quiescencePenney Gilbert University of Toronto Canada15 30 15 45Generation of complex human induced pluripotent stem cell derived bone marrow organoids to model hematopoietic development and disease Stephanie Frenz Wiessner Dr von Hauner Children s Hospital Ludwig Maximilians University Munich GermanyNot available on demand15 45 16 00Cerebral organoids display dynamic clonal growth with lineage replenishment Christopher Esk University of Innsbruck Austria16 00 16 25Cardiovascular diseases and drugs where are we with hiPSC models Christine Mummery Leiden University Medical Centre The NetherlandsNot available on demand16 25 16 45Flash talks 106 iPSC derived human organoid based model of intestinal filovirus infectionFlores Elizabeth Yvonne 164 Volumetric compression by heterogeneous scaffold embedding promotes cerebral organoid growth and maturationMa Shaohua 172 Generation and characterization of microgliacontaining human forebrain assembloidsMichels Susanne 220 Covalent tracking of DNMT1 specific activity in lung cancer spheroids Stankevicius Vaidotas 236 Collective organization of circadian rhythms in murine intestinal organoidsTonin Elena 238 Screening gastric cancer patient derived organoids develops the first in class anti invadopodia therapeutic antibodyTsai Kelvin Kunchih 242 Exploring human inner ear organoids Singlecell analysis of oto pharyngeal development and comparative profiling to human inner ear tissue across developmental stagesvan der Valk Wouter 254 Differentiated tubuloids to model human distal nephron Patho PhysiologyPou Casellas Carla16 45 18 45Poster Session 2 even with beer and snacksView poster listing here18 45 21 00Conference dinner in the canteen 21 00 00 00Party with Who2Ladies Day 4 Saturday 21 October 2023 Time Europe Berlin Speaker09 00 12 25Session 5 Organoids in disease modelingSession Chair Karl Koehler Boston Children s Hospital and Harvard Medical School09 00 09 25Guiding Intestinal Stem Cell Fate Kim Bak Jensen University of Copenhagen DenmarkNot available on demand09 25 09 40Salmonella Typhimurium and Shigella flexneri use alternative virulence strategies to colonize the human enteroid and colonoid epithelium Petra Geiser Uppsala University Sweden09 40 09 55Extracellular signaling in neurodevelopmental disordersSilvia Cappello Ludwig Maximilian University of Munich GermanyNot available on demand09 55 10 25Coffee Break and Meet the speakers10 25 10 50Organoid cellular cancer immunity models in motion Anne Rios The Princess Maxima Center of Pediatric Oncology10 50 11 05RFX6 Regulates Human Intestinal Patterning and Function J Guillermo Sanchez Cincinnati Children s Hospital United States of America11 05 11 30Liver organoids to study regeneration and cancer across biological scalesMeritxell Huch Max Planck Institute of Molecular Cell Biology and Genetics GermanyNot available on demand11 30 11 45Isogenic patient derived organoids reveal early neurodevelopmental defects in spinal muscular atrophy initiationNatalia Rodriguez Muela German Center for Neurodegenerative Diseases DZNE Germany11 45 12 10Genetic screening and neural network pathology in cerebral organoids J rgen Knoblich Institute of Molecular Biotechnology IMBA AustriaNot available on demand12 10 12 25Closing Remarks and Poster Prize Announcement12 25 12 45Packed Lunch and departure12 45Airport shuttle to terminal 1 30 EUR tickets may be purchased on site Practical informaton Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Lea Hohmann for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 20 September 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 11 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 CLICK HERE FOR THE BUS SCHEDULE as of 10 October 2023 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Gold Sponsors Silver Sponsors Bronze sponsors Event sponsors Axion BioSystems Bio Techne BIOMEX Cell Research MaxWell Biosystems Molecular Devices Nikon Europe BV Optics11 Life The FEBS Journal World Precision Instruments Xceltis GmbH Event supporter Media partners Disease Models Mechanisms The Company of Biologists Journal Development The Company of Biologists journal EMBO Journal an EMBO Press journal FEBS Journal a FEBS Press journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Open Biology a Royal Society journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 Pre conference workshops For on site participants only The following industry workshops will be hosted by the sponsors of EMBO EMBL Symposium Organoids modelling organ development and disease in 3D culture prior to the start of the event Three Dimensional Reconstitution of Liver Epithelial Tissue Structures ex vivo Enhanced with Animal Origin Free Recombinant Proteins and Culture Media by Prof Tanimizu The University of Tokyo Helix B01 Imaging and Analysis of 3D cell cultures using ZEISS microscope systems and Arivis by Dr Volker D ring and Dr Philipp Seidel Carl Zeiss Microscopy GmbH Main Auditorium Deep live cell imaging with new IXplore SpinSR NIR add on by Stefan Marawske Kristina Mayer EVIDENT Europe FlexLab A Innovations in In Vitro Tissue Modeling Hepatic and Airway Organoids by Riya Sharma and Salvatore Simmini STEMCELL Technologies FlexLab B Newer technologies assisting the sustainable disease modelling by Karthi Rajamani Takara Bio Helix A01 on Wednesday 18 October 2023 14 30 15 30 In order to read the abstract of each workshop please click on the corresponding links above Participation in this workshop is free of charge for registered on site conference attendees The available place is limited first come first served All registered conference attendees will receive an email with a registration link shortly All pre conference workshops will take place simultaneously therefore please choose the one you would be interested in the most...

Meritxell Huch, Karl R. Koehler, Madeline Lancaster, Esther Schnapp

17 October - 19 October 2023

Open Virtual Ensembl REST API Workshop

Description Work with Ensembl to master the Ensembl REST API and flexibly access genome wide data such as genes variants regulatory features homologues and alignments...

Louisse Paola Mirabueno

11 October 2023

Accessing and interpreting predicted protein structures from AlphaFold database

Description AlphaFold database AlphaFold DB provides open access to over 200 million protein structure predictions to accelerate scientific research This webinar aims to provide a comprehensive introduction to AlphaFold DB Participants will gain a clear understanding of the fundamental concepts principles and functionalities of the database They will learn how to access and evaluate predicted protein structures explore the underlying technologies and algorithms used in AlphaFold and identify the potential applications of AlphaFold DB in their research...

11 October - 14 October 2023

The non-coding genome

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Over the past two decades advances in transcriptomic methods have led to the discovery of a very rich and diverse set of RNA transcripts short and long that serve as regulators rather than templates for protein production Many of these transcribed elements are encoded in noncoding regions of the genome with other regulatory and structural DNA elements of known and unknown functions While the catalogs of such elements are very rich and an ever increasing number are implicated in almost every known biological process there are still many key open questions Often these important problems are tackled and discussed within different sub communities including the mature fields of microRNAs miRNAs and piRNAs and the emerging fields focused on longer linear noncoding RNAs lncRNAs circular RNAs circRNAs and other non transcribed yet functional genomic elements This symposium traditionally brings together members of these communities enabling researchers focusing on different classes of non coding elements to interact and learn from each other We are pleased to return to doing this at an in person meeting this year following the virtual edition held in 2021 For 2023 the main pillars of the meeting will remain with sessions on miRNAs piRNAs lncRNAs and circRNAs alongside sessions showcasing less RNA centric fields such as heterochromatin and telomere biology and transcribed regulatory regions Topics that have received relatively limited attention in previous meetings will also feature such as ncRNAs in plants and RNA therapeutics which has become a particularly active field due to the current pandemic Session topics Small RNAs Non coding genome and disease Unconventional RNA structure and mechanisms Transcriptional regulation by non coding RNA and DNA Genome organisation and epigenetic regulation and development Long non coding RNAs What past participants say about the symposium The Non coding Genome was a truly inspiring meeting both in terms of topics and the excellent level of the talks with a good balance of novel and published work Thanks to the organisers for providing me the opportunity to present my latest work at this high profile event which also enabled networking with peers publishers and industries Roberto Simone UCL UK Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speakers Julius Brennecke Institute of Molecular Biotechnology Austria Ling Ling Chen Shanghai Institute of Biochemistry and Cell Biology China Speakers Peter Andersen Aarhus University Denmark David Bartel Massachusetts Institute of Technology USA Fr d ric Berger Gregor Mendel Institute of Molecular Plant Biology Austria Nadya Dimitrova Yale University USA Ines Drinnenberg Institut Curie France Archa Fox The University of Western Australia Australia Maite Huarte Universidad de Navarra Spain Nicola Iovino Max Planck Institute of Immunobiology and Epigenetics Germany Joanna Jachowicz Institute of Molecular Biotechnology Austria Jeannie Lee Harvard Medical School USA Katherine McJunkin National Institute of Diabetes and Digestive and Kidney Diseases USA Eric Miska University of Cambridge UK Shinichi Nakagawa Hokkaido University Japan Michael Nodine Wageningen University Research The Netherlands Claire Rougeulle Epigenetics and Cell Fate Centre France Edda Schulz Max Planck Institute for Molecular Genetics Germany Cynthia Sharma Julius Maximilians Universit t W rzburg Germany Yukihide Tomari The University of Tokyo Japan J rg Vogel Helmholtz Centre for Infection Research Germany Scientific organisers Marc B hler Friedrich Miescher Institute for Biomedical Research Switzerland Ana Eul lio Imperial College London UK Joshua Mendell UT Southwestern Medical Center USA Gisela Storz National Institutes of Health USA Igor Ulitsky Weizmann Institute of Science Israel Conference organiser Inna B sselmann EMBL Heidelberg Germany Programme Got something to say Tweet it EESNoncoding Please note that the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event All times in the programme below are shown as the time in Europe Berlin Programme is preliminary and subject to change Day 1 Wednesday 11 October Time Europe Berlin Title 11 30 13 00 Registration and light refreshments13 00 13 15Opening remarksSession 1 Small RNAsChairs Joshua Mendell and Ana Eulalio13 15 13 40 Argonaute catalyzed slicing and conformational dynamicsDavid Bartel Massachusetts Institute of Technology USA13 40 14 05Changeability of piRNA production patterns negatively correlates with the efficiency of their biogenesisYukihide Tomari The University of Tokyo Japan14 05 14 30 Theme and variations Emerging diversity in mechanisms of miRNA decayKatherine McJunkin National Institute of Diabetes and Digestive and Kidney Diseases USA14 30 14 55Small RNA functions in plant embryosMichael Nodine Wageningen University Research The NetherlandsNot available on demand14 55 15 25Coffee break15 25 15 50Regulation of protein activity by base pairing small RNAsGisela Storz National Institutes of Health USA15 50 16 05Natural and genetically engineered mammalian canonical RNAi in vivoPetr Svoboda Czech Academy of Sciences Czech Republic16 05 16 20agoTRIBE detects microRNA target interactions transcriptome wide in single cells Marc Friedl nder Stockholm University Sweden16 20 16 35Casein kinase 1 and 2 phosphorylate a conserved cluster of argonaute to control microRNA function Vivek Nilesh Shuah Chu de Qu bec Universit Laval Cancer Research Center Canada16 35 16 50Quantitative measurement of RNA protein interactions in vivo Dmitry Kretov Boston University School of Medicine USA16 50 17 20Coffee break17 20 18 05 Keynote talk 1 Biogenesis function and potential application of circular RNAsLing Ling Chen Shanghai Institute of Biochemistry and Cell Biology China18 05 19 30Dinner in canteen19 30 21 00 Drinks in ATC rooftop lounge Day 2 Thursday 12 October Time Europe Berlin Title Session 2 Non coding genome and diseaseChairs Edda Schulz and Nadya Dimitrova09 00 09 25Deregulation of long noncoding RNAs in cancerNadya Dimitrova Yale University USA09 25 09 50CRISPR Cas9 based endogenous RNA targeting in bacteria from discovery to applicationsSahil Sharma University of W rzburg Germany09 50 10 15Leveraging bacterial RNA biology knowledge for the development of programmable RNA antibioticsJ rg Vogel Helmholtz Centre for Infection Research Germany10 15 10 40Unravelling the role of microRNAs in bacterial pathogen host interactionAna Eul lio Imperial College London UKNot available on demand10 40 11 10Coffee break11 10 11 25SINEUP RNA rescues molecular phenotypes associated with CHD8 suppression in Autism Spectrum Disorder model systems Marta Biagioli University of Trento Italy11 25 11 40Haploinsufficiency of human DGCR8 results in primate specific RNAs dysregulation and pluripotency defects Ana Colomer Boronat University of Granada Spain11 40 11 55Positive feedback amplification of antiviral signaling by endogenous double stranded RNAs in autoimmune diseases Doyeong Ku Korea Advanced Institute of Science and Technology Republic of Korea11 55 12 10The Alzheimer s disease risk factor RBFOX1 is a major regulatory hub for Alzheimer associated circRNAs Sambhavi Puri Boston University School of Medicine USA 12 10 13 30Meet the speakers and lunchSession 3 Unconventional RNA structure and mechanismsChairs Gisela Storz and Julius Brennecke13 30 13 55Confined environments induce polarized paraspeckle condensatesArcha Fox The University of Western Australia AustraliaNot available on demand13 55 14 20piRNA dynamics in mammalian genomesEric Miska University of Cambridge UK14 20 14 45Diversity of spatial genome organization Insights from LepidopteraInes Drinnenberg Institut Curie France14 45 15 00Molecular and physiological functions of circRNAs in the brain Sebastian Kadener Brandeis University USA15 00 15 30Coffee break meet the editors15 30 15 45A direct protein protein interaction network of cytoplasmic Drosophila piRNA pathway factors Mandy Jeske Heidelberg University Germany15 45 16 00Unistrand piRNA clusters have repeatedly emerged across the Drosophila genus to control endogenous retroviruses of the Gypsy family Susanne Bornel v University of Cambridge UK16 00 16 15Epstein Barr virus non coding RNA steers ribosomes into virus favorable translation Nara Lee University of Pittsburgh USA 16 15 16 45Flash talks 116 45 18 45Poster session 1 odd numbers 18 50Free evening Day 3 Friday 13 October Time Europe Berlin TitleSession 4 Transcriptional regulation by non coding RNA and DNAChairs Lingling Chen and Maite Huarte09 00 09 25The ChAHP complexesMarc B hler Friedrich Miescher Institute for Biomedical Research Switzerland09 25 09 50Contribution of lncRNAs to the control of X chromosome activity in early human developmentClaire Rougeulle Epigenetics and Cell Fate Centre France09 50 10 15Information processing at the Xist locusEdda Schulz Max Planck Institute for Molecular Genetics Germany10 15 10 40Recurrent innovation of germline genome regulation through paralog adaptationPeter Andersen Aarhus University Denmark10 40 11 10Coffee break11 10 11 35Epigenetic regulation by RNA G QuadruplexesJeannie Lee Harvard Medical School USANot available on demand11 35 11 50Mechanisms of long noncoding RNA dependent chromatin repression Aaron Johnson University of Colorado School of Medicine USA11 50 12 05Inseparable RNA binding and chromatin modification activities of a nucleosome interacting surface in PRC2 Chen Davidovich Monash University EMBL Australia Australia12 05 12 20LINE1 regulate human T cell function by assembling chromatin into condensates Beatrice Bodega University of Milan Italy12 20 13 30Meet the speakers and lunchSession 5 Genome organisation and epigenetic regulation and development Chairs Marc Buehler and Jeannie Lee13 30 13 55Inheritance of H3K9 methylation regulates genome architecture in early embryosNicola Iovino Max Planck Institute of Immunobiology and Epigenetics Germany13 55 14 20Meta analysis of RNA chromatin interaction datasetsIgor Ulitsky Weizmann Institute of Science Israel remote talk 14 20 14 45Short stories about long RNAs during early mammalian developmentJoanna Jachowicz Institute of Molecular Biotechnology Austria14 45 15 10Organization of the epigenetic information and its impact on transcriptionFr d ric Berger Gregor Mendel Institute of Molecular Plant Biology Austria15 10 15 40Coffee break15 40 15 55The lncRNA Sweetheart regulates compensatory cardiac hypertrophy after myocardial injury Sandra Rogala Georg Speyer Haus Germany15 55 16 10Network like condensation of satellite DNA into chromocenters safeguards nuclear mechanostability Franziska Br ndle ETH Zurich Switzerland16 10 16 25The effect of lncRNAs on gene regulation and inter chromosomal topology Philipp Maass SickKids Research Institute Canada remote talk 16 25 16 40Genome organization and lncRNAs synergistically control the dynamics of Hox gene expression during development Philippe Batut Princeton University USA16 40 17 10Flash talks 217 10 19 10Poster session 2 even numbers 19 10 21 00Conference dinner in the canteen21 00 24 00Party in the ATC foyer Day 4 Saturday 14 October Time Europe Berlin TitleSession 6 Long non coding RNAsChairs Archa Fox and Claire Rougeulle09 00 09 25Regulation of alternative splicing by short noncoding RNAShinichi Nakagawa Hokkaido University JapanNot available on demand09 25 09 50Noncoding RNA roles in the coordination of DNA replication and stress signalingMaite Huarte Universidad de Navarra Spain09 50 10 15New functions and regulators of noncoding RNAs in mammalsJoshua Mendell Howard Hughes Medical Institute UT Southwestern Medical Center USANot available on demand10 15 10 30A unified model for the surveillance of translation in diverse noncoding sequences Xuebing Wu Columbia University USA10 30 11 00Coffee break11 00 11 45piRNA guided transcriptional silencingKeynote talk 2 Julius Brennecke Institute of Molecular Biotechnology Austria11 45 12 00The Unexpected Match STAT3 NORAD Interaction a Novel Link in Antiviral Defense Amir Argoetti Yael Mandel Gutfreund Technion Israel Institute for Technology Israel remote talk 12 00 12 15The interplay between lncRNA CHERR and chromatin remodelling complex in cell division and lung cancer developmentGiulia Guiducci Barts Cancer Institute UK12 15 12 30Lncfoxp3 controls cell identity and function of human regulatory t cells Stefano Abbiati IFOM ETS The AIRC Institute of Molecular Oncology Italy12 30 12 45Closing remarks and poster prize12 45 13 30Packed lunch13 30DepartureOptional Bus to Frankfurt airport Terminal 1 Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Inna Boesselmann for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only 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how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting 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HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings You can now find the Conference Bus Schedule here The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event You can find the final bus schedule here Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains 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buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsor Arraystar Inc Cell Research Event supporters Media partners Advanced Biology a Wiley Online Library Bio Essays a Wiley Online Library International Union of Biochemistry and Molecular Biology FEBS Journal a FEBS Press journal FEBS Letters a FEBS Press journal FEBS Open Bio a Febs Press journal Molecular Systems Biology an EMBO Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Marc Bühler, Anna Eulálio, Joshua Mendell, Gisela Storz, Igor Ulitsky

10 October - 12 October 2023

Open Virtual Ensembl Browser Workshop

Description Work with the Ensembl Outreach team to get to grips with the Ensembl browser accessing gene variation comparative genomics and regulation data and mine these data with BioMart...

Benjamin Moore

9 October - 13 October 2023

Liquid biopsies

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course Overview There is an increasing interest and need to analyse biomarkers in liquid biopsies including basic research and clinical applications Liquid biopsies have several advantages including being minimally invasive allowing repeated sampling and sampling is often clinical routine This course will provide an overview of the several techniques to detect and analyse liquid biopsy based analytes such as circulating tumour cells cell free tumor DNA ctDNA miRNA extracellular vesicles mRNA carbohydrates and proteins Participants will be introduced to all aspects ranging from proper sampling through analyte analysis and final data analysis Experimentally we will demonstrate ultrasensitive ctDNA analysis using sequencing and digital PCR In addition targeted miRNA profiling and flow cytometry with single cell analysis will be highlighted We will cover aspects of other analytes by lectures and we will have a strong focus on applications especially cancer applications Aspects of biobanking and clinical implementation will also be highlighted Audience This course targets scientists entering the field of liquid biopsy analysis and wanting to learn about the benefits and limitations of different approaches Modules Resources Ultra sensitive mutation detection using sequencing Flow cytometry and single cell analysis Digital PCR applications in the liquid biopsy workflow Hands on data analysis and interpretations Learning Outcomes Participants will receive an overview of various experimental workflows in liquid biopsies from sample preparation to data analysis The course provides an overview of current theories methods and emerging applications Whereby a strong focus will be on experimental design best practices pitfalls as well as dos and don ts After the course participants should be able to assess the best methods for their application as well as design their experiment What past participants say about the course This was a great course that has helped me understand the basics as well as gain in depth knowledge on liquid biopsies Simply phenomenal M A Bari Siddiqui All India Institute of Medical Sciences Speakers Speakers trainers and staff J rg Bantin Bio Rad Germany Anders Edsj Sk ne University Hospital Sweden Daniel Gimenes EMBL Heidelberg Germany Tony E Godfrey Boston University School of Medicine USA An Hendrix Ghent University Belgium Romy Kirsten University Hospital Mannheim Germany Mikael Kubista Institute of Biotechnology of the Czech Academy of Sciences Czech Republic Ulf Landegren Uppsala University Sweden Manuel Luna Santamar a Sahlgrenska Academy at University of Gothenburg Sweden Tobias sterlund Sahlgrenska University Hospital Sweden Hilal Ozgur EMBL Heidelberg Germany Kim Pettersson University of Turku Finland Michael Pfaffl Technical University of Munich Germany Beata Ramasz EMBL Heidelberg Germany Pia Scheu Bio Rad Germany Anders St hlberg University of Gothenburg Sweden Karin Sundfeldt University of Gothenburg Sweden Jessica Sutter EMBL Heidelberg Germany Val rie Taly Paris Descartes University France Scientific organisers Anders St hlberg University of Gothenburg Sweden Karin Sundfeldt University of Gothenburg Sweden Course organisers Sophie Dutzi Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLLiquidBiopsies Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 9 October 2023 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel08 45 09 00RegistrationFlex Lab A B09 00 09 30Welcome and house notes and course overviewFlex Lab A B09 30 10 30Background SimSen protocol lectureAnders St hlberg Sahlgrenska Academy at University of Gothenburg SwedenKarin Sundfeldt University of Gothenburg SwedenFlex Lab A BFlexible Coffee BreakIn front of Training Lab Area10 30 12 00Practical session 1 DNA extraction Manuel Marceliano Luna Santa Mar a Sahlgrenska Academy at University of Gothenburg Sweden Hilal Ozgur EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg GermanyTraining Lab B12 00 13 00LunchEMBL Canteen13 00 14 30Practical session 2 SiMSen Seq library preparation Manuel Marceliano Luna Santa Mar a Sahlgrenska Academy at University of Gothenburg Sweden Hilal Ozgur EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg GermanyTraining Lab B14 30 15 00Coffee breakIn front of Training Lab Area15 00 16 30Ice breaker Flash talksFlex Lab A B16 30 17 00Q A session to pre recorded lectures Anders St hlberg Sahlgrenska Academy at University of Gothenburg SwedenFlex Lab A B17 00 18 30Practical session 3 SiMSen Seq Clean Up and quality controlManuel Marceliano Luna Santa Mar a Sahlgrenska Academy at University of Gothenburg Sweden Hilal Ozgur EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg GermanyTraining Lab B18 30 20 30Pizza and Poster Session 1ATC Helix B20 30Departure to HotelATC Entrance Day 2 Tuesday 10 October 2023 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 05Overview of the dayFlex Lab A B09 05 10 00Lecture Single Cell Sorting Beata Ramasz EMBL Heidelberg GermanyFACS Facility GeneCore FacilityFlexible Coffee BreakIn front of Training Lab Area10 00 12 00Practical session 4 Single Cell Sorting Beata Ramasz EMBL Heidelberg Germany Daniel Gimenes EMBL Heidelberg Germany GeneCore tourFACS Facility GeneCore Facility12 00 12 30Practical session 5 SiMSen Seq QCLibrary poolingAnders St hlberg Sahlgrenska Academy at University of Gothenburg SwedenHilal Ozgur EMBL Heidelberg GermanyJessica Sutter EMBL Heidelberg GermanyTraining lab B12 30 13 30LunchCanteen13 30 14 30Lecture Exosomal Biomarkers in Liquid Biopsies How to identify valid and better Biomarker Signatures from micro vesicular small RNA SequencingMichael Pfaffl Technical University of Munich GermanyFlex Lab A B14 30 15 00Practical session 6 Single cell RTManuel Marceliano Luna Santa Mar a Sahlgrenska Academy at University of Gothenburg Sweden Hilal Ozgur EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg GermanyTraining lab B15 00 16 00Lecture Introduction to ddPCRJ rg Bantin Bio Rad GermanyFlex Lab A B16 00 16 30Practical session 7 Single cell qPCRManuel Marceliano Luna Santa Mar a Sahlgrenska Academy at University of Gothenburg Sweden Hilal Ozgur EMBL Heidelberg Germany Jessica Sutter EMBL Heidelberg GermanyTraining lab B16 30 16 45Coffee breakIn front of Training Lab Area16 45 18 30Practical session 8 ddPCRJ rg Bantin BioRad GermanyPia Scheu Bio Rad GermanyTraining lab B18 30 19 30Practical session 9 PCR setup droplet generation and cyclingStart reading the experimentJ rg Bantin BioRad GermanyPia Scheu Bio Rad GermanyTraining lab B19 30 21 30Poster session 2 tapasATC Helix B21 30Departure to HotelATC Entrance Day 3 Wednesday 11 October 2023 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayFlex Lab A B09 15 11 15Practical session 10 Data analysis with QX Manager J rg Bantin BioRad Germany Pia Scheu Bio Rad GermanyFlex Lab A B11 15 11 30Coffee breakIn front of Training Lab Area11 30 12 30Lecture Role of biobanks in securing process quality in sample retrieval and storageRomy Kirsten University Hospital Mannheim GermanyFlex Lab A B12 30 13 30Technology lunchRooftop Lounge13 30 14 30Lecture Effect of pre analytical factors on the measurement of Evs in Liquid BiopsiesAn Hendrix Ghent University BelgiumFlex Lab A B14 30 15 30Title to be confirmedNayara Azevedo Roche GermanyFlex Lab A B15 30 16 00Coffee break and Course PictureIn front of Training Lab Area16 00 17 00Lecture Clinical validation of droplet based procedures in the context of liquid biopsiesValerie Taly Paris Descartes University FranceFlex Lab A B17 00Free evening17 00Departure to HotelIn front of ATC entrance17 30Bus to Neckarm nzplatzBus stop in front of ISG Hotel Day 4 Thursday 12 October 2023 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayFlex Lab A B09 15 10 15Lecture Europium nanoparticle based test concept for glycovariants of traditional and novel biomarkers to provide enhanced cancer specifictyKim Pettersson University of Turku FinlandFlex Lab A B10 15 10 45Coffee breakIn front of Training Lab Area10 45 11 45Lecture Protein detection in Liquid BiopsiesUlf Landegren Uppsala University SwedenFlex Lab A B11 45 12 45Poster group discussionFlex Lab A B12 45 13 45LunchEMBL Canteen13 45 14 45Lecture Diagnostic potential of tumor DNA in proximal fluids in gynecologic cancer Karin Sundfeldt Sahlgrenska Academy at University of Gothenburg SwedenFlex Lab A B14 45 16 00Lecture two tailed PCR Mikael Kubista Institute of Biotechnology and TATAA Biocenter Czech RepublicComputer Training Lab16 00 16 30Coffee breakIn front of Training Lab Area16 30 18 00Practical session 11 Single cell analysis Data analysis and complianceMikael Kubista Institute of Biotechnology of the Czech Academy of Sciences Czech RepublicComputer Training Lab18 00 18 30Departure to Hotel and DowntownIn front of ATC entrance18 30 19 30Free Time in the City Centre19 30 22 00Course dinner downtown Day 5 Friday 13 October 2023 Time Europe Berlin ProgrammeLocation08 40 09 00Bus from hotel to EMBL ATC EntranceBus stop in front of ISG Hotel09 00 09 15Overview of the dayFlex Lab A B09 15 10 15Lecture Liquid Biopsies in the clinical contextHigh fidelity sequencingTony E Godfrey Boston University School of Medicine USAFlex Lab A B10 15 10 30Coffee breakComputer Training Lab10 30 12 00Practical session 12 multivariate analysis Mikael Kubista Institute of Biotechnology and TATAA Biocenter Czech RepublicComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 16 00Practical session 13 SiMSen Seq Data analysis Tobias sterlund and Manuel Marceliano Luna Santa Mar a Sahlgrenska Academy at University of Gothenburg SwedenComputer Training Lab16 00 16 30Coffee BreakComputer Training Lab16 30 17 30Lecture Implementing liquid biopsies in the clinic needs obstacles and possibilitiesAnders Edsj Sk ne University Hospital SwedenFlex Lab A B17 30 18 00Course wrap upFlex Lab A B18 00Departure to the HotelIn front of ATC entrance18 30DinnerISG Hotel Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Academia 790PhD Student 790Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights 9 14 October 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code LIQ23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Course partners Course sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Anders Ståhlberg, Karin Sundfeldt

9 October - 13 October 2023

Metagenomics bioinformatics at MGnify

Description Overview Learn about the tools processes and analysis approaches used by MGnify in the field of genome resolved metagenomics This course will cover the use of publicly available resources to manage share analyse and interpret metagenomics data focussing primarily on the assembly based approaches used in MGnify analysis The delivered content will involve participants learning via live lectures and presentations followed by live Q As with the trainers Practical experience will be developed in group activities and in computational exercises run using containerised tools on our training infrastructure...

Meredith Willmott

5 October 2023

Poster winners, PerMedCoE Summer School 2023

Description This special edition of the PerMedCoE webinar series features speakers who were awarded poster prizes at the PerMedCoE Summer School 2023 Find out more about our speakers and their research Towards Tailored Cancer Therapies Robust platform for drug testing in patient specific Boolean models Viviam Berm dezComputational modelling of High Grade Serous Ovarian Cancer HGSOC Marco Fari asDissecting cellular communication in the tumour microenvironment through multiscale dynamical modelling Malvina MarkuAbout the speakerViviam Berm dez is a PhD candidate at the Norwegian University of Science and Technology specialising in Boolean models Her academic journey began in general biology back in her home country Venezuela at Sim n Bol var University Then she hopped over to Norway for a one year student exchange where she unexpectedly found herself staying longer to complete a master s degree in molecular cell biology diving deep into systems biology and cell modelling Now in her Computational Cancer Biology PhD she combines machine learning and modelling to address complex challenges of precision medicine Beyond her coding skills she also has green fingers so she finds peace caring for her plants during her free time Looking ahead she aspires to contribute to the field of precision medicine through her PhD project and continue exploring the fascinating world of digital twins without forgetting the ethical side of things Marco Fari as originally from Ponferrada in north western Spain is an enthusiastic nature lover who enjoys spending free time outdoors His academic journey began with a Bachelor s degree in Biology at the Complutense University of Madrid Following his interest for cellular and molecular biology he moved to Trondheim Norway where he pursued a Master s degree at the Norwegian University of Science and Technology NTNU During this period Marco did his thesis focusing on Boolean modelling of macrophage polarisation and its relevance to acute COVID 19 This research was conducted under the guidance of Martin Kuiper within the DrugLogics group Following the completion of the Master s program Marco moved to Barcelona and joined Marta Cascante s research group at Barcelona University There he delved into the intricate metabolic alterations triggered by SARS CoV 2 infection In his latest pursuit Marco returned to Trondheim to start his PhD journey at NTNU under the supervision of Kaisa Lehti His research leverages Boolean modelling to explore the dynamics of the tumour microenvironment and its influence on the aggressiveness of high grade serous ovarian cancer Malvina Marku studied her undergraduate degree in Physics at the University of Tirana Albania where she pursued her MSci project in the field of Nonlinear Dynamics studying the qualitatively universal behaviour of recursive systems As a PhD student on Computational Physics at the University of Tirana her PhD thesis focused on mathematical modelling of regulatory networks and inference methods of network reaction rates She joined Pancaldi s lab at the Cancer Research Center of Toulouse as a postdoc where she is currently working on multi scale dynamical modelling of the tumour microenvironment The research is focused on Chronic Lymphocytic Leukaemia CLL microenvironment and the crucial role of the cancer cell immune cell interaction in defining the cancer cell survival Her main interest is in applying dynamical modelling and networks theory to study the dynamics and emerging behaviour of complex biological systems and to gain a deeper understanding of systems evolution from the molecular network perspective She is interested in using computational models that are able to capture emerging biological behaviour and evolving patterns in spatially structured tumours for enabling more accurate and clinically relevant predictions regarding disease course and treatment outcome...

Viviam Bermúdez, Marco Fariñas, Malvina Marku

4 October 2023

Studying genes and genomes with Ensembl genome browser

Description The Ensembl genome browser provides data on genes variants comparative genomics and gene regulation for over 300 species Its sister project Ensembl Genomes www ensemblgenomes org consists of five sub portals bacteria fungi protists plants and invertebrate metazoa which contain data for over 2 000 eukaryotic including wheat barley tomato and brassicas and over 30 000 prokaryotic genomes This webinar will provide the participants with an introduction on how to use the Ensembl genome browser navigate the website and export data...

4 October - 7 October 2023

Seeing is believing: imaging the molecular processes of life

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kitPre conference workshopsLunch workshops Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview The molecular processes of life are naturally dynamic in space and time from the atomic to the organismal level The rapid development of imaging methods across the full scale of biological organisation is revolutionising our ability to visualise the inner workings of macromolecular complexes organelles cells tissues organs and whole organisms Being able to see biological processes unfold in real time allows us to understand the mechanisms of life as well as disease The symposium will bring together the leading developers of imaging methods with cutting edge applications that illustrate how imaging can answer biological questions We will emphasize methods that can capture the dynamics of life spanning the whole range from molecular resolution to imaging of whole organisms From its beginning in 2011 Seeing is Believing has embraced novel imaging technologies that open new windows for biological discovery including single molecule and super resolution light sheet and correlative light electron microscopy The symposium provides many opportunities for presentations discussions and interactions between students postdocs junior and senior investigators Session topics Imaging structure and function of single molecules in situ Tissue and organoid imaging Probes biosensors Organismal and intravital imaging Image analysis modelling New approaches to imaging What past participants say about the symposium This conference was very well organised great talks and exciting new tools and techniques were presented I am very happy I attended Highly recommend for everybody interested in microscopy Alina Gavrilov Hoffmann La Roche Switzerland The EMBL symposium was well organised and executed The combination of field expert talk and technical field talk made researchers very much aware about subject research and available advance imaging facility and their applications Dr Vijay K Verma Dept of Microbiology University of Delhi South Campus India I was happy to attend this amazing meeting full of talks showing incredible combinations of the most recent state of the art techniques some of which even looked like being from far future or sci fi Marketa Schmidt Cernohorska Max Perutz Labs Vienna Austria Seeing Is Believing maybe you have to see it to believe me how AMAZING this conference is Three days filled with the latest around microscopy biology and data analysis presented by the big names and the young but rising stars A delight Florian Jug Fondazione Human Technopole ItalyPlease see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Speakers Ibrahim Ciss Max Planck Institute of Immunobiology and Epigenetics Germany Lucy Collinson Francis Crick Institute UK Qionghai Dai Tsinghua University China Xavier Darzacq University of California Berkley USA Meghan Driscoll University of Minnesota USA Jan Ellenberg EMBL Heidelberg Germany Sebastian Eustermann EMBL Heidelberg Germany Ronald Germain National Institute of Allergy and Infectious Diseases USA Anna Kreshuk EMBL Heidelberg Germany Jennifer Lippincott Schwartz HHMI Janelia Research Campus USA Ons M Saad Panluminate USA Satyajit Mayor National centre for Biological Sciences India Atsushi Miyawaki RIKEN Center for Brain Science Japan Jonas Ries EMBL Heidelberg Germany Loic Royer Chan Zuckerberg Biohub USA Andrej Sali University of California San Francisco USA Erdinc Sezgin SciLifeLab Sweden Marvin Tanenbaum Hubrecht Institute The Netherlands Aubrey Weigel Janelia Research Campus USA Scientific organisers Jan Ellenberg EMBL Heidelberg Germany Jennifer Lippincott Schwartz HHMI Janelia Research Campus USA Satyajit Mayor National centre for Biological Sciences India Atsushi Miyawaki RIKEN Center for Brain Science Japan Conference organisers Iva Gavran Course and Conference Officer EMBL Heidelberg Germany Programme Got something to say Tweet it EESImaging For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Programme is subject to change Day 1 Wednesday 4 October 2023 Time Europe Berlin Speaker10 45 11 30Registration for workshop participants11 30 12 30Industry pre conference workshops registration required 11 30 13 00Registration and light refreshments13 00 13 15Opening remarksSession 1 Imaging structure and function of single molecules in situChaired by Xavier Darzacq University of California Berkley USA13 15 13 35Super resolution imaging of transcription in living cellsIbrahim Ciss Max Planck Institute of Immunobiology and Epigenetics Germany13 35 13 55Single molecule tracking using proximity assisted photoactivation to study the dynamics of proteins engaged in multiple macromolecular assembliesXavier Darzacq University of California Berkley USA13 55 14 15Exploring the principles of energy driven chromatin organisationSebastian Eustermann EMBL Heidelberg Germany14 15 14 35Localization influences macromolecular complex composition Origin of Nuclear Pore Complex AsymmetryJenny Sachweh Max Planck Institute of Biophysics Germany14 35 14 55Studying viral infection dynamics and heterogeneity using single molecule microscopyMarvin Tanenbum Hubrecht Institute The Netherlands14 55 15 40Coffee Break in Foyer and Meet the invited speakers in the CTY Foyer with Ibrahim Ciss Xavier Darzacq Sebastian Eustermann and Marvin Tanenbumkindly sponsored by ATTO TEC15 40 16 00Direct observation of motor protein stepping in living cells using MINFLUXJonas Ries EMBL Heidelberg Germany16 00 16 20Motion of single VAPB molecular tethers reveals a metastable structure at ER mitochondria contact sitesChris Obara HHMI Janelia Research Campus USA16 20 16 40Mitochondria move via distinct transport modesJulius Winter EPFL Switzerland16 40 17 00Measuring biophysical properties of cells and bioparticles in health and diseaseErdinc Sezgin Karolinska Institutet Sweden17 00 17 20Unveiling the ultrastructural landscape of native extracellular matrix via lift out cryo FIB and cryo ETBettina Zens Institute of Science and Technology Austria Austria17 20 19 00Poster Sneak peek session 19 00 20 30Conference dinner20 30 22 00Poster Sneak peek session continued Day 2 Thursday 5 October 2023 Time Europe Berlin SpeakerSession 2 Tissue and organoid imagingChaired by Jennifer Lippincott Schwartz HHMI Janelia Research Campus USA09 00 09 20Uncovering brain tissue architecture with super resolution light microscopyJohann Danzl Institute of Science and Technology Austria AustriaNot available on demand09 20 09 40Automated live cell single molecule imaging reveals the molecular dynamics of overexpressed Sox9 associated with a cancerous state transition in intestinal organoidsNike Walther University of California Berkeley USANot available on demand09 40 10 00Imaging of cancer cell dynamics in vitro and in situ from a whole organism to subcellular imaging with self driving multi scale microscopyStephan Daetwyler UT Southwestern Medical Center USA10 00 10 45Coffee Break and Meet the editors in ATC FoyerMeet the speakers in CTY Foyer with Jonas Ries and Erdinc Sezginkindly sponsored by ATTO TEC10 45 11 05Open top dual view light sheet microscope for live imaging of large multicellular systems in multi well formatFranziska Moos Friedrich Miescher Institute Switzerland11 05 11 25Exploring life across scales with volume correlative light and electron microscopyLucy Collinson Francis Crick Institute UK11 25 11 45Do synaptic like mechanisms control insulin secretion in pancreatic cells Kylie Dang University of Sydney Australia11 45 12 05Investigating the spatial distribution dynamics and regulation of translation of mRNAs encoding secretory and membrane proteins by single molecule trackingJennifer Lippincott Schwartz HHMI Janelia Research Campus USA12 05 14 05Lunch break Lunch workshop by Thermo Fisher Scientific12 35 13 35 Courtyard Room AEMBL Imaging centre tours sign in sheets at the registration desk Meeting point registration deskPlease be there a few minutes before the start of tour12 15 12 55 Tour 113 05 13 45 Tour 2Session 3 Probes biosensorsChaired by Atsushi Miyawaki RIKEN Center for Brain Science Japan14 05 14 25Sensitized acceptor anisotropy with dim fluorescent donor to monitor FRET induced angular displacementHideaki Mizuno KU Leuven Belgium14 25 14 45Highly specific and non invasive imaging of Piezo1 dependent activity across scales using GenEPiKonstantinos Kalyviotis Imperial College London UK14 45 15 05Chemigenetic kinase biosensors for multiplexed activity sensing and super resolution imagingMichelle Frei University of California San Diego USANot available on demand15 05 15 50Coffee Break and Meet the editors in ATC FoyerMeet the speakers in CTY Foyer with Lucy Collinson and Jennifer Lippincott Schwartz kindly sponsored by ATTO TEC15 50 16 10Colors by Shape EMcapsulins as multi channel gene reporters for Electron Microscopy and correlative imaging modalitiesGil Westmeyer Technical University of Munich Germany16 10 16 30Chemically programmable bacterial probes for the recognition of cell surface proteinsLeila Motiei Weizmann Institute of Science IsraelNot available on demand16 30 16 50A locally activatable sensor for robust quantification of organellar GSHSarah Emmert University of Z rich Switzerland16 50 17 10Continuity in space and timeAtsushi Miyawaki RIKEN Center for Brain Science Japan17 10 17 40Flash talksPoster numbers odd 63 85 91 109 147 149 155 157 161 163 173 185 195 197 209 21117 40 19 10Poster Session 1 odd with beer and snacks19 10 20 30Conference dinner20 30 22 30Pub quiz in the Canteen Day 3 Friday 6 October 2023 Time Europe Berlin SpeakerSession 4 Organismal intravital imagingChaired by Jan Ellenberg EMBL Heidelberg Germany09 00 09 20Imaging the structure and mechanism of mitotic chromosome folding in human cells and mouse embryosJan Ellenberg EMBL Heidelberg Germany09 20 09 40Programmed disassembly of an Interplanar Amida Network coordinates 3D epithelial growthOsamu Shimmi University of Helsinki Finland09 40 10 00Zebrahub Multimodal Zebrafish Developmental Atlas Reveals the State Transition Dynamics of Late Vertebrate Pluripotent Axial ProgenitorsLoic Royer Chan Zuckerberg Biohub USA10 00 10 45Coffee Break in Foyer and Meet the invited speakers in the CTY Foyer with Lin Tian Atsushi Miyawaki Jan Ellenberg and Loic Royer kindly sponsored by ATTO TEC10 45 11 05Highly Multiplex 2D and 3D Imaging Methods and Analytical Tools for Probing Cell Organization and Function in Complex Tissue SettingsRonald Germain National Institute of Allergy and Infectious Diseases NIH USANot available on demand11 05 11 25Deep Brain Tumor Imaging Through Customized Three Photon Microscopy and AnalysisVarun Venkataramani University Heidelberg GermanyNot available on demand11 25 11 45High resolution line scan Brillouin microscopy for live imaging of mechanical properties during embryo developmentCarlo Bevilacqua EMBL Heidelberg Germany11 45 12 05Computational intravital fluorescence mesoscopyQionghai Dai Tsinghua University ChinaNot available on demand12 05 14 05Lunch break Lunch workshop by BD Life Sciences12 35 13 35 Courtyard Room AEMBL Imaging centre tours sign in sheets at the registration desk Meeting point registration deskPlease be there a few minutes before the start of tour12 15 12 55 Tour 313 05 13 45 Tour 4Session 5 Image analysis modellingChaired by Meghan Driscoll University of Minnesota USA14 05 14 25Life in the cytoplasm computational microscope captures in cell protein dynamicsTaras Pogorelov University of Illinois Urbana Champaign USANot available on demand14 25 14 45From integrative structural biology to cell biologyAndrej Sali University of California San Francisco USA14 45 15 05Exploring the universe of sub and multicellular organizationAubrey Weigel Janelia Research Campus HHMI USA15 05 15 50Coffee Break in Foyer and Meet the invited speakers in the CTY Foyer with Ronald Germain Qionghai Dai Andrej Sali and Aubrey Weigelkindly sponsored by ATTO TEC15 50 16 10Image analysis from the perspective of the 3D cell surfaceMeghan Driscoll University of Minnesota USA16 10 16 30Learning to explore phenotypesAnna Kreshuk EMBL Heidelberg Germany16 30 16 50Deciphering the randomness of lineage decisions in early developing mouse embryosGesa Loof Aix Marseille Universit France16 50 17 10ultrack large scale versatile cell tracking in Python under segmentation uncertaintyJordao Bragatani Chan Zuckerberg Biohub USA17 10 17 40Flash talksPoster numbers even 58 76 108 128 140 166 182 192 200 204 210 21817 40 19 10Poster Session 2 even with beer and snacks19 15Bus departures to Heidelberg Castle please show your dinner ticket when entering the bus and the castle 19 30Bus departures downtown for free evening 19 45 01 00Conference dinner and Party at the Heidelberg castle dinner ticket holders only or Free evening Day 4 Saturday 7 October 2023 Time Europe Berlin SpeakerSession 6 New approaches to imagingChaired by Satyajit Mayor National Centre for Biological Sciences India09 30 09 50 ngstr m resolution fluorescence microscopyIsabell Baudrexel Max Planck Institute of Biochemistry Germany09 50 10 10DNA tracing reveals the nanoscale organization of chromatin loops and domainsKai Beckwith Norwegian University of Science and Technology Norway10 10 10 30HiExM high throughput expansion microscopy enables scalable super resolution imagingJohn Day Massachusetts Institute of Technology USA10 30 11 15Coffee Break in Foyer and Meet the invited speakers in the CTY Foyer with Meghan Driscol Anna Kreshuk Ons M Saad and Satyajit Mayorkindly sponsored by ATTO TEC11 15 11 35 pan OptiX Illuminating the Nanostructural Landscape of Tissues and Cells for Precision MedicineOns M Saad Panluminate USA11 35 11 55Single molecule peptide identification using fluorescence blinking fingerprintsSalome P ntener University of Z rich Switzerland11 55 12 15Examining virus cell interactions via confocal iSCAT microscopyVahid Sandoghdar Max Planck Institute for the Science of Light Germany12 15 12 35Imaging the living cell membrane bilayer leaflet by leafletSatyajit Mayor National Centre for Biological Sciences IndiaNot available on demand12 35 12 50Closing Remarks and Poster Prize12 50 13 20Packed Lunch and departure13 20Shuttle bus to downtown13 30Shuttle bus to Frankfurt airport tickets sold at reception Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Iva Gavran for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Wednesday 6 September 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 09 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergHotel MonptiB B HotelISG Hotel Premier Inn Heidelberg CityExzellenz HotelLeonardo Hotel Heidelberg City CentreStaycity Aparthotel HeidelbergHotel Holl nder Hof Meininger HeidelbergHotel Vier Jahreszeiten Heidelberg Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Conference bus shuttle schedule The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop in front of Monpti hotel ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions and travelling to EMBL on our Information for participants page Sponsors Platinum Sponsor Gold Sponsors Silver Sponsors Bronze Sponsors Event sponsors Abberior Instruments ASI Applied Scientific Instrumentation ATTO TEC BD Life Sciences Biosciences Chip NanoImaging DECTRIS AG MicroscopeHeaters com Hamamatsu Photonics H BNER Photonics Interherence Nikon Europe BV PicoQuant SmarAct GmbH tebu bio GmbH Event supporters Media partners EMBO reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Journal of Cell Science a The Company of Biologists journal Open Biology a Royal Society journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Imaging and Microscopy a Wiley Journal PLOS Biology a PLOS journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 x 9 Leaderboard 728 x 90 Pre conference workshops For on site participants only The following industry workshops will be hosted by the sponsors of EMBO EMBL Symposium Seeing is believing imaging the molecular processes of life prior to the start of the event High throughput light sheet microscopy for delicate and large samples and how to handle the data by Felix WELTZIEN Luxendo GmbH Bruker Fluorescence Microscopy Room Helix B01 Simultaneous multicolor quantitative and auto calibrated TIRF imaging with the new Abbelight TIRF solution by Ipek Altinoglu Abbelight and Buelent Peker EVIDENT Europe Room Flexlab B Rare event detection with Autonomous Microscopy powered by Aivia and Coral Life workflow for Live Cell CLEM by J rgen Reymann and Robert Kirmse Leica Microsystems Room Flexlab A Untying your hands Using optical tweezers to go beyond just imaging by Emma Verver LUMICKS Room Court Yard Room B A benchtop super resolution platform for single molecule imaging and analysis by Ricardo Bastos ONI Room Helix A01 Add a new dimension to live imaging Use your Airyscan detector and uncover spatial molecular dynamics in your current samples by Dr Annette Bergter Carl Zeiss Microscopy GmbH Room Court Yard Room A on Wednesday 4 October 2023 11 30 12 30 In order to read the abstract of each workshop please click on the corresponding links above Participation in this workshop is free of charge for registered on site conference attendees The available place is limited first come first served All registered conference attendees will receive an email with a registration link shortly All pre conference workshops will take place simultaneously therefore please choose the one you would be interested in the most Lunch workshops For on site participants only The following lunch workshops will be hosted by the sponsors of EMBO EMBL Symposium Seeing is believing imaging the molecular processes of life will prior to the start of the event Image acquisition and analysis solutions for volume EM and cryo tomography by Alex Rigort and Maximilian Voll Thermo Fisher Scientific on Thursday 5 October 12 35 13 35 Room Court Yard Room A BD FACSDiscover S8 Cell Sorter See what you sort and sort what you see with BD CellView and BD SpectralFX Technologies by Tim Schenkel BD Life Sciences Biosciences on Friday 6 October 12 35 13 35 Room Court Yard Room A In order to read the abstract of each workshop please click on the corresponding links above Participation in this workshop is free of charge for registered on site conference attendees The available place is limited first come first served All registered conference attendees will receive an email with a registration link shortly...

Jan Ellenberg, Jennifer Lippincott-Schwartz, Satyajit Mayor, Atsushi Miyawaki

2 October - 6 October 2023

Structural bioinformatics

Description This course provides a guide to the commonly used methods and tools in structural bioinformatics to analyse and interpret experimentally determined and AI predicted macromolecular structure data Structural biology determining the three dimensional shapes of biomacromolecules and their complexes can tell us a lot about how these molecules function and the roles they play within a cell Data derived from structure determination experiments and Artificial Intelligence AI assisted structure prediction enables life science researchers to address a wide variety of questions This course explores bioinformatics data resources and tools for the investigation analysis and interpretation of both experimentally determined and predicted biomacromolecular structures It will focus on how best to analyse and interpret available structural data to gain useful information given specific research contexts The course content will also cover predicting function and exploring interactions with other macromolecules Successful participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course...

Sophie Spencer

2 October - 4 October 2023

Signaling through Chromatin: from molecules to ecosystems

Description If you are not redirected please visit the event website...

27 September 2023

Nucleotide sequencing data submission and retrieval at the ENA

Description The European Nucleotide Archive ENA is an open access supported platform for the management sharing integration archiving and dissemination of sequence data The archive provides a comprehensive record of the world s nucleotide sequencing information covering raw sequencing data sequence assembly information and functional annotation This webinar will introduce you to the data and metadata structures for nucleotides at the ENA It will support you in learning about how you can submit data to this archive and retrieve submitted data relevant to your field of work...

21 September 2023

A guided tour of improvements to the UniProt website

Description This webinar will provide an interactive introduction to the UniProt website Developed with our user community in mind the website aims to allow users to access all data provided by the UniProt consortium while being adaptable enough to meet the evolving needs of our users Join us to find out how our website is structured to enable users to better navigate and find content in our various databases Also discover how to use our tools BLAST Align Peptide search and ID mapping and how to organise them in the Tools results dashboard where the user can view and revisit their previous BLAST Align Peptide search or ID mapping jobs save them as favourites or resubmit them We hope that this interactive webinar will introduce you to all the features and show you some of the latest improvements we implemented into the new website...

20 September 2023

Using RNAcentral to explore and investigate non-coding RNA sequences

Description Non coding RNAs ncRNAs are a key molecule for life They are involved in many complex biological processes from gene regulation to translation This complexity has led to an explosion of many different databases with specialised focuses and data RNAcentral provides users a single entry point into the complexity of ncRNA data This webinar will show users how to effectively navigate and search RNAcentral Additionally we will show users how to download data for their own analysis and tooling We will highlight commonly used data formats such as BED GFF3 and FASTA files Finally we will demonstrate how to use the RNAcentral sequence search to quickly explore sequences...

20 September - 23 September 2023

The human microbiome

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPre conference workshop Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Human microbiota the collection of microbes living in and on our body have a significant impact on human health and well being They have been associated with numerous diseases yet we are still far from understanding their role in the context of lifestyle and genetics Various initiatives are underway around the world to survey the human microbiota at several body sites characterise them understand their interactions with the human hosts elucidate their role in diseases and design possible therapeutic or dietary interventions There is a new wave of studies mining the human microbiota for health relevant bioactive compounds for characterising specific microbial strains and for cataloguing the human microbiota from all across the globe This conference will provide plentiful opportunities for researchers to learn about and to connect to important developments in studying the human microbiota The return of this established meeting will bring together the community for a timely in person symposium picking up on developments across the field since the last edition in 2018 For 2023 sessions will focus on the human microbiome across biological time and in nutrition and drugs host microbe interactions integrative approaches in microbiome research and methodological advances in microbiome analysis The final session will look to the future of microbiome research and translation Session topics Methodological advances in microbiome analysis The human microbiome across biological age The human microbiome in nutrition and drugs Host microbe interactions Integrative approaches in microbiome research Future outlook for microbiome research and translation What past participants say about the conference This meeting was in my top 3 of best meetings ever that I attended The atmosphere was very lively with lots of good discussions with diverse scientists The topic microbiome research was covered extremely well I am looking forward to attending the next time this meeting is taking place Peter van Baarlen Wageningen University the Netherlands Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Speakers Yasmine Belkaid remote speaker National Institute of Allergy and Infectious Diseases NIH USA Clara Belzer Wageningen University The Netherlands Maria Carmen Collado Spanish National Research Council Spain Mahesh Desai Luxembourg Institute of Health Luxembourg Kenya Honda Keio University School of Medicine Japan Curtis Huttenhower Harvard University USA Rob Knight University of California San Diego USA Sarah Lebeer University of Antwerp Belgium Ruth Ley Max Planck Institute for Biology Germany Lisa Maier University of T bingen Germany Eric Martens University of Michigan USA Julia Salzman Stanford University USA Eran Segal Weizmann Institute of Science Israel Harry Sokol Saint Antoine Hospital France Gene Tyson Queensland University of Technology Australia Paul Wilmes University of Luxembourg Luxembourg Moran Yassour The Hebrew University of Jerusalem Israel Alexandra Zhernakova University of Groningen The Netherlands Scientific Organisers Manimozhiyan Arumugam University of Copenhagen Denmark Ami Bhatt Stanford University USA Peer Bork EMBL Heidelberg Germany Nicola Segata University of Trento Italy Conference Organiser Lea Hohmann EMBL Heidelberg Germany Aline Schnieder EMBL Heidelberg Germany Programme Got something to say Tweet it EESMicrobiome Programme is preliminary and subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 20 September 2023 Time Europe Berlin Speaker11 15 13 00Registration and light refreshments11 45 12 45Pre conference workshop Robust and versatile ultra high throughput single microbe genome sequencing by Atrandi Biosciences registration required 13 00 13 30Opening remarks and lightning talks by Scientific OrganisersSession 1 Methodological advances in microbiome analysisSession chair Manimozhiyan Arumugam13 30 14 00A pipeline for developing novel therapeutics from the human microbiomeGene Tyson Queensland University of Technology Australia14 00 14 15Ex vivo cultivation model of the complex human gut microbiota for investigating modulation approaches and spatial interactionsAnnelies Geirnaert ETH Zurich Food Biotechnology SwitzerlandNot available on demand14 15 14 30Detecting Natural Selection in the Human MicrobiotaSur Herrera Paredes Universidad Nacional Aut noma de M xico Mexico14 30 15 00Systems ecology of the human expobiomePaul Wilmes University of Luxembourg Luxembourg15 00 15 30Coffee break and meet the speakers15 30 15 45Identification of eukaryotic symbionts and diet as bycatch in human gut microbiome dataOleksandr Maistrenko Royal Netherlands Institute for Sea Research Netherlands15 45 16 Kinetic modeling and in vitro fermentation reveal how gut microbiota impacts bioactivation and bioavailability of phytoestrogensMaja Stevanoska ETH Zurich SwitzerlandNot available on demand16 00 16 30Ultra fast reference free genomics algorithm discover novel genomic regulation in the microbial worldJulia Salzman Stanford University USA Remote speaker 16 30 17 00The Isala project and the vaginal microbiomeSarah Lebeer University of Antwerp Belgium17 00 18 30Global Grants for Gut Health symposium17 00 17 05 Welcome and Introductory RemarksAmi Bhatt Stanford University USA17 05 17 30 Bile Acid Conjugation as a New Mechanism of Host Microbiome CrosstalkRobert Quinn Michigan State University USA17 30 17 55 Using genomics to decode infant dietary diversity and microbiome maturationLawrence David Duke University USA17 55 18 20 Gut microbiome metabolites and growth in children at risk of malnutritionEvans Mudibo Wageningen University KEMRI Wellcome Trust Research Programme18 20 18 25 Concluding RemarksAmi Bhatt Stanford University USA18 30 20 00Dinner in EMBL Canteen20 00 21 00After dinner drinks and speed networking optional 20 00 20 30 Day 2 Thursday 21 September 2023 Time Europe Berlin SpeakerSession 2 The human microbiome across biological ageSession chair Peer Bork09 30 10 00Maternal infant microbiota Factors shaping microbial transfer assembly and evolutionMaria Carmen Collado Spanish National Research Council CSIC Spain10 00 10 15Longitudinal culturing of the developing human microbiome reveals temporal and spatial differentiation between distal body sitesSara Di Simone Hudson Institute of Medical Research Australia10 15 10 30Tracking the transmission of the gut microbiome a one health perspectiveMireia Valles Colomer Pompeu Fabra University Spain10 30 11 00Coffee break and meet the speakers11 00 11 30Toward the development of defined microbial therapeuticsKenya Honda Keio University School of Medicine JapanNot available on demand11 30 11 45Gut metagenomic profiling of 1 800 African women reveals novel microbial diversity and associations with cardiometabolic healthJakob Wirbel Stanford University USA11 45 12 00Unsaturated long chain fatty acids differentially modulate growth of vaginal Lactobacillus speciesMeilin Zhu MIT USANot available on demand12 00 12 30Longitudinal Variability of Bifidobacterium Species in the Infant Gut is Independent of Maternal Milk HMO CompositionMoran Yassour The Hebrew University of Jerusalem IsraelNot available on demand12 30 14 00LunchSession 3 The human microbiome s response to nutrition and drugsSession chair Ami Bhatt14 00 14 30The consequences of drugging the gut microbiome from the individual microbe to the hostLisa Maier University of T bingen GermanyNot available on demand14 30 14 45Baseline gut microbiome predicts the efficacy of randomized oral antihypertensives in patients with essential hypertensionLianmin Chen Nanjing Medical University China14 45 15 00Emergence of community behaviors in the gut microbiota upon drug treatmentSarela Garcia Santamarina ITQB NOVA Portugal15 00 15 30Coffee break and meet the speakers15 30 16 00Dietary fiber and mucin degrading bacteria in inflammatory bowel diseaseEric Martens University of Michigan USA16 00 16 15Investigating microbial dark matter unveils a consistent gut metagenomic biomarker for response to immune checkpoint blockade across diverse cohortsChan Yeong Kim EMBL Heidelberg Germany16 15 16 30Immunotherapy and microbiome unique set of taxa and genes associated with antibiotics useGiacomo Vitali INRAE France16 30 17 00Gut Microbial Synthetic communities to study how microbial ecologic networks collaboratively ferment glycans from diet and mucinClara Belzer Wageningen University The Netherlands17 00 18 30Poster session 1 odd numbers with beer and snacksPlease see the poster overview here Free evening Day 3 Friday 22 September 2023 Time Europe Berlin SpeakerSession 4 Host microbe interactionsSession chair Nicola Segata09 30 10 00Silent flagellins or how the gut immune system turns a blind eyeRuth Ley Max Planck Institute for Biology Germany10 00 10 15Bacterial DNA inversions and functional plasticity during inflammation and encounter with bacteriophagesShaqed Carasso Technion Israel Institute of Technology Israel10 15 10 30Host Microbiome Interactions between Lesional Skin Microbiome and Genomic Profiles in Psoriasis Susceptibility Loci Predisposes to Psoriasis Vulgaris in Indian PatientsSouvik Mukherjee National Institute of Biomedical Genomics India10 30 11 00Coffee break and meet the speakers11 00 11 30Leveraging diet to engineer the gut microbiomeMahesh Desai Luxembourg Institute of Health LuxembourgNot available on demand11 30 11 45A role for the gut microbiome in determining the rate of progression of amyotrophic lateral sclerosisMaria Emilia Panzetta Duke University USA11 45 12 00Extravesicles secreted by human gut GABA producing Bacteroides sp a possible shuttle mechanism for neuroactive metabolitesBasit Yousuf University of Ottawa Canada12 00 12 30Talk title tbcYasmine Belkaid National Institute of Allergy and Infectious Diseases NIH remote speaker12 30 14 00Lunch and Meet the editorsSession 5 Integrative approaches in microbiome researchSession chair Maria Carmen Collado14 00 14 30Microbiome multi omics and the Human Microbiome Bioactives ResourceCurtis Huttenhower Harvard University USA14 30 14 45Microbial sub species diversity and its interactions with host physiologyLiron Zahavi and Saar Shoer Weizmann Institute of Science Israel14 45 15 00Multi view integration of microbiome data for predicting host diseaseEfrat Muller Tel Aviv University Israel15 00 15 30Coffee break and meet the speakers15 30 16 00Development of gut microbiome and virome during the first year of lifeAlexandra Zhernakova University of Groningen The Netherlands16 00 16 15Gut microbial genetic architecture of human healthYue Zhang and Doaming Wang University Medical Center Groningen The NetherlandsNot available on demand16 15 16 30Exploration of 1000 human gut viromes and matched metagenomes discovers phages with unexpected integration potential and broad host rangeLore Van Espen KU Leuven Belgium16 30 17 00Personalized medicine based on deep human phenotypingEran Segal Weizmann Institute of Science Israel17 00 18 30Poster session 2 even numbers with beer and snacksPlease see the poster overview here 18 30 00 00Conference dinner at Heidelberg Castle with band limited seating first come first served Day 4 Saturday 23 September 2023 Time Europe Berlin SpeakerSession 6 Future outlook for microbiome research and translationSession chair Moran Yassour09 30 10 00High throughput approaches for integrated microbiome and metabolome studiesRob Knight University of California San Diego USA10 00 10 15Unraveling the complex interplay between the human gut microbiome diet and cardiometabolic health from the ZOE PREDICT studiesFrancesco Asnicar University of Trento Italy10 15 10 30Revealing the reservoir and spread of antimicrobial resistance in the human gut microbiota using the controlled human infection modelIrina Chelysheva University of Oxford United Kingdom10 30 11 00Coffee Break and Meet the speakers11 00 11 30Host microbiome tryptophan metabolism in IBDHarry Sokol Saint Antoine Hospital France11 30 11 45Fecal metabolic dysbiosis is associated with 30 day mortality of patients on the medical intensive care unitAlexander de Porto University of Chicago USA11 45 12 00Harnessing gut microbiota for risk assessment and therapeutics of NAFLDYueqiong Ni Leibniz Institute for Natural Product Research and Infection Biology Hans Kn ll Institute HKI Germany Remote speaker 12 00 12 15Key metabolic interactions define microbiota response to nutrient changesRemy Young Hudson Institute of Medical Research Australia12 15 12 30Discovery and development of anaerobic microbial choline metabolism inhibitors that target novel proteins beyond the choline utilization gene clusterAmelia Woo Harvard University USANot available on demand12 30 12 45Closing Remarks and Poster Prize12 45 13 15Packed Lunch and departure13 15Buses to downtown Heidelberg and 1 bus to Frankfurt airport terminal 1 30 EUR tickets may be purchased on site Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Aline Schnieder for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 23 August 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 08 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreHotel Vier Jahreszeiten HeidelbergExzellenz HotelMeininger HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings You can now find the Conference Bus Schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop in front of Hotel Monpti ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expression Where is the nearest Covid test centre Wo ist das n chste Covid Testzentrum HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Where is the nearest COVID 19 test centre Wo ist das n chste COVID 19 Testzentrum Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Silver sponsor Bronze sponsors Session sponsor Event sponsor BaseClear CosmosID Don Whitley Scientific MP Biomedicals Media partners Disease Models Mechanisms The Company of Biologists Journal EMBO Molecular Medicine an EMBO Press journal FEBS Journal a FEBS Press journal FEBS Letters a FEBS Press journal FEBS Open Bio a FEBS Press journal International Union of Biochemistry and Molecular Biology PLOS Biology a PLOS journal Open Biology a Royal Society journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PTT slide 16 9 Leaderboard 728 90 Pre conference workshop For on site participants only This industry webinar will be hosted by our sponsor Atrandi Biosciences prior to the EMBO EMBL Symposium The human microbiome on Wednesday 20 September 2023 11 45 12 45 Participation in this workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served All registered conference attendees will receive an email with a registration link ABSTRACT Robust and versatile ultra high throughput single microbe genome sequencing by Linas Pupelis Justyna MazulAtrandi Biosciences Whole genome and targeted sequencing open a window to understanding the function of unculturable microorganisms On one hand metagenomic sequencing is attractive for its straightforward sequencing library preparation from bulk environmental samples but only offers limited resolution into individual species On the other hand single microbe sequencing offers true single clone resolution but can only meaningfully address the high biological diversity expected in environmental samples if performed on thousands of individual cells in parallel To satisfy the need to study such large numbers of single microbes per sample well and droplet based approaches keep evolving in parallel to provide single cell compartmentalization required during sequencing library preparation However these approaches suffer from a fundamental trade off between throughput and versatility Being individually addressable microwells enable multi step processing but are not scalable Droplets offer a throughput of up to a million cells per experiment but only allow a limited number of processing steps to be performed The later limitation is severely felt when it comes to microbial research as harsh conditions typically required for lysis are incompatible with downstream nucleic acid barcoding steps Our Semi Permeable Capsule SPC technology combines the throughput of droplets with the versatility of wells by enabling a virtually unlimited number of processing steps on genetic material from millions of individual microbes in parallel We demonstrate the use of SPCs for barcoding 100 000 individual microbial genomes to obtain single microbe whole genome sequencing data of unprecedented quality...

Manimozhiyan Arumugam, Ami Bhatt, Peer Bork, Nicola Segata

19 September - 22 September 2023

CCPBioSim workshop: structural bioinformatics resources and tools for molecular dynamics simulations

Description This introductory workshop will provide hands on training on protein and structural bioinformatics resources in the context of molecular dynamics biomolecular modelling and simulations The workshop is sponsored by the Collaborative Computational Project for Biomolecular Simulation CCPBioSim Participants will gain knowledge and skills for searching selecting and assessing publicly available protein biodata for use in downstream methods relating to biomolecular modelling and molecular dynamics simulations The workshop will begin with an introduction to basic concepts in genomics and associated resources then to protein resources their uses and limitations and validation of both experimentally and predicted protein structures Finally the workshop will cover variant effect prediction and offer participants hands on group projects to bring together the previous days training with highly experienced mentors During this time participants will work with simulated datasets to answer small research questions then present findings thereafter Participants will also get the chance to network with one another trainers and workshop organisers...

Jane Reynolds

18 September - 22 September 2023

Single cell RNA-seq analysis using Python

Description This course covers the analysis of single cell RNA sequencing scRNA seq data using Python and command line tools Participants will be guided through droplet based scRNA seq analysis pipelines from raw reads to cell clusters You will explore and interpret single cell RNA seq data using Python as well as the Single Cell Expression Atlas Finally you will put their knowledge into practice through a group challenge on the last day Please note that you will not analyse your own data as part of the course There will however be ample opportunity to discuss your research and ideas with other course participants and trainers Virtual course Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning you will not require access to a powerful computer or install complex software on your own machines Participants will need to be available between the hours of 09 00 17 30 BST each day of the course Trainers will be available to assist answer questions and provide further explanations during these times This course is currently under construction and so details are subject to change Please note that we will operate this course virtually Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic...

Juanita Riveros

17 September - 22 September 2023

Genome engineering: CRISPR/Cas from cells to mice

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview Course overview This course will provide training in genome editing and cell engineering in mammalian cells and mouse embryos using the highly efficient CRISPR Cas9 system Participants will learn design of CRISPR targets using bioinformatics tools generation of gene knock outs knock ins and target validation using the most current technologies The course will be split into two groups mammalian cells OR mice based on participants expertise Please note that all participants are expected to engage in all sessions Participants should plan for approximately 1 hour extra per day for self paced learning modules Audience This course is aimed at researchers who are familiar with basic molecular and cell biology techniques and who want to learn how to create an engineered mammalian cell line or mouse model using the most recent and advanced CRISPR Cas9 system No previous experience in genome editing is required Modules resources How to create a CRISPR Cas9 experiment using various design tools Transfection optimisation for efficient gene editing Generation of knock out and knock in cell lines and mouse embryos Validation of genome edited cell lines and embryos Learning outcomes After this course you should be able to Design a CRISPR based project using editing tools for your target gene of interest Choose the right format of gene editing tool and delivery strategy for your cell type or embryos Edit screen and validate the engineered models embryo manipulation What past participants say about the course The EMBL course about CRISPR applications for genome engineering was an incredible experience From the quality of the lectures the availability of the invited speakers to respond to all questions and doubts the openness and diversity of participants to the great organization and the impressive facilities and core facility teams working there It all created a perfect atmosphere for learning about this groundbreaking technique and the inspiring work being done with it as well as great networking I highly recommend this course Sofia Morazzo International Clinical Research Center Czech Republic The course covers all you need to organise your CRISPR experiments in great detail The speakers are fantastic and eager to help with your specific questions The organisation is also fantastic where you only have to think on CRISPR and nothing else Sergio G San Miguel Max Planck Institute for Infection Biology Germany Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Antony Adamson The University of Manchester UK Michela Ascolani EMBL Rome Italy Alessandro Barenghi EMBL Rome Italy Dana Carroll University of Utah School of Medicine USA Silke Deckert Thermo Fisher Scientific Germany Julian Gr newald Technical University of Munich Germany Manuel Kaulich Universit tsklinikum Frankfurt Germany Frank Montoya EMBL Heidelberg Germany Beate Neumann EMBL Heidelberg Germany Alexandre Paix EMBL Heidelberg Germany Kim Remans EMBL Heidelberg Germany Isabel Rollan EMBL Heidelberg Germany Daniel Schraivogel EMBL Heidelberg Germany Maj Simonsen Jackson EMBL Rome Italy Kieran Van Kessel Thermo Fisher Scientific UK Scientific Organisers Neil Humphreys EMBL Rome Italy Kristof Kersse Thermo Fisher Scientific Germany Birgit Koch Max Planck Institute for Medical Research Germany Elisabeth Zielonka EMBL Heidelberg Germany Course Organisers Chris Stocks Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez Training Lab EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLCRISPRcas Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 17 September 2023 Time Europe Berlin SessionLocation 16 00 16 30 Registration ISG Hotel16 30 17 30Arrival WelcomeIntroduction to course design ISG Seminar room 17 30 18 00IcebreakerISG Seminar room 18 00 19 00Live Keynote Lecture Introduction to CRISPR Cas 9Dana Carroll University of Utah School of Medicine USA this talk will be remote ISG Seminar room 19 00Dinner Networking ISG Hotel Day 2 Monday 18 September 2023 Time Europe Berlin Session Location08 30 08 45 Bus from ISG Hotel to EMBL ISG Hotel08 45 09 00 Overview of the dayCourtyard Room09 00 12 15Day 2 Guide RNA Design09 00 09 15Lab SafetySwetlana Kretz EMBL Heidelberg GermanyCourtyard Room09 15 10 15Practical 1 gRNA Donor design Kristof Kersse Thermo Fisher Scientific GermanyTraining Lab A B10 15 11 15Practical 1 gRNA Donor designBirgit Koch Max Planck Institute for Medical Research GermanyTraining Lab A B11 15 11 45Coffee 11 45 12 30 Practical in groups11 45 12 30Mammalian Cell GroupPractical 1 1 TrueTag Donor Template Synthesis PCRSilke Deckert Thermo Fisher Scientific GermanyKristof Kersse Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UKTraining Lab A 11 45 12 30Mouse Embryo GroupGlass transfer pipet prep harvest embryos and short seminar on embryo transfer and demonstration Neil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyAlessandro Barenghi EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Montoya EMBL Heidelberg GermanyTraining Lab B12 30 13 30Lunch 13 30 14 30Lecture A rationale for efficient genome editing using linear repair donorsAlexandre Paix EMBL Heidelberg GermanyCourtyard Room14 30 16 00Practical 1 2Mammalian Cell Group TrueTag Donor Template Synthesis Gel analysis and Clean upSilke Deckert Thermo Fisher Scientific GermanyKristof Kersse Thermo Fisher Scientific Germany Kieran Van Kessel Thermo Fisher Scientific UKTraining Lab A14 30 16 00Practical 1 2Mouse Embryo Group Intro to TLR2 system describe injection mix prep microinjection zygotes electroporation Electroporation Maj Simonsen Jackson EMBL Rome Italy Michela Ascolani EMBL Rome Italy Alessandro Barenghi EMBL Rome ItalyMicroinjection Neil Humphreys EMBL Rome Italy Isabel Rollan EMBL Heidelberg Germany Frank Diego Montoya Castillo EMBL Heidelberg Germany Sandra Stobrawa Biozol Calibre ScientificTraining Lab B16 00 16 30Coffee 16 30 18 00Practical 2 3Mammalian Cell GroupGroup A gRNA efficiency Lipid transfection of 293FT cells with gRNA and Cas9 protein Lipid transfection of 293FT eBFP cells with gRNA Cas9 protein and ssODNSilke Deckert Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UKGroup B Guide RNA design taskBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyCell Culture Flex Lab16 30 18 00Mouse Embryo Group 2nd Microinjection electroporation and AAVElectroporation Maj Simonsen Jackson EMBL Rome Italy Michela Ascolani EMBL Rome Italy Alessandro Barenghi EMBL Rome ItalyMicroinjection Neil Humphreys EMBL Rome Italy Isabel Rollan EMBL Heidelberg Germany Frank Diego Montoya Castillo EMBL Heidelberg Germany Sandra Stobrawa Biozol Calibre ScientificTraining Lab A B18 00 19 00Dinner 19 00 20 30Practical 2 3Mammalian Cell GroupGroup B gRNA efficiency Lipid transfection of 293FT cells with gRNA and Cas9 protein Lipid transfection of 293FT eBFP cells with gRNA Cas9 protein and ssODNSilke Deckert Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UK Group A Guide RNA design taskBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyTraining Lab A B19 00 20 30Practical 2 3Mouse Embryo GroupExtra time with Embryos microinjection and embryos transfer KSOM media O N cultureNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyAlessandro Barenghi EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Montoya EMBL Heidelberg GermanyTraining Lab A B20 30Bus from EMBL to ISG Hotel Day 3 Tuesday 19 September 2023 Time Europe Berlin SessionLocation08 30 08 45 Bus from ISG Hotel to EMBL08 45 09 15Overview of the day09 15 10 15Lecture Gene editing in different experimental modelsAntony Adamson The University of Manchester UKCourtyard Room10 15 11 15Practical Lecture Mammalian Cell Group Generation and validation of endogenously tagged cell lineBirgit Koch Max Planck Institute for Medical Research Germany Courtyard Room10 15 11 15Practical 4 Mouse Embryo Group Assess and clean up 2 cell microinjected embryosNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyIsabel Rollan EMBL Heidelberg Germany Frank Montoya EMBL Heidelberg GermanyTraining Lab A B11 15 11 45Coffee11 45 12 45Lecture CRISPR Prime EditingJulian Gr newald Technical University of Munich GermanyCourtyard Room12 45 13 45Lunch 13 45 15 45Practical 1 3 4Mammalian Cell GroupGroup A Tag Knock in Electroporation of 293FT with gRNA Cas9 protein and TrueTag donor templateSilke Deckert Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UK Group B Project discussionBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyCell Culture Flex LabCourtyard Room13 45 15 45Practical 4Mouse Embryo GroupThaw pre prepared blastocysts assess viability and extract DNANeil Humphreys EMBL Rome Italy Michela Ascolani EMBL Rome Italy Maj Simonsen Jackson EMBL Rome Italy Isabel Rollan EMBL Heidelberg Alessandro Barenghi EMBL Rome ItalyTraining Lab A B 15 45 16 15Coffee 16 15 18 15Practical 1 3 4Mammalian Cell GroupGroup B Tag Knock in Electroporation of 293FT with gRNA Cas9 protein and TrueTag donor templateSilke Deckert Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UK Group A Project discussionBirgit Koch Max Planck Institute for Medical Research GermanyKristof Kersse Thermo Fisher Scientific GermanyCell Culture Flex Lab16 15 18 15Practical 5Mouse Embryo GroupSet up T7 assay and mutant specific PCRsNeil Humphreys EMBL Rome Italy Michela Ascolani EMBL Rome Italy Maj Simonsen Jackson EMBL Rome Italy Alessandro Barenghi EMBL Rome Italy Training Lab A B18 15 19 15DinnerCanteen19 45Bus from EMBL to ISG hotelEMBL Bus stop Day 4 Wednesday 20 September 2023 Time Europe Berlin SessionLocation08 30 08 45 Bus from ISG Hotel to EMBL 08 45 09 15Overview of the dayCourtyard Room09 15 10 15Lecture Daniel SchraivogelEMBL Heidelberg GermanyCourtyard Room10 15 12 15Practical in GroupsMammalian Cell Group Practicals 5 1 5 2 GCD Cell Harvest and lysis set up GCD PCRSilke Deckert Thermo Fisher Scientific GermanyKristof Kersse Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UKTraining Lab B 10 15 12 15Mouse Embryo Group Practicals 5 1 5 22Assess and clean up 4 to 8 cell embryos Run Gels for PCRsSet up T7 assay and digestion assay PCRs Neil Humphreys EMBL Rome Italy Michela Ascolani EMBL Rome Italy Maj Simonsen Jackson EMBL Rome ItalyAlessandro Barenghi EMBL Rome Italy Isabel Rollan EMBL Heidelberg GermanyTraining Lab A 12 30 13 15Lunch 13 15 13 30Group photo13 30 14 30Lecture The 3Cs technology for CRISPR gRNA library generationManuel Kaulich Goethe University GermanyCourtyard Room14 30 16 30Practical in GroupsPractical 5 3 Mammalian Cell GroupCR analysis set up GCD re annealing reactionPractical 5 4 5 5Set up digestion for GCD gel purification sample submission for sanger sequencingGel analysis of GCDSilke Deckert Thermo Fisher Scientific GermanyKristof Kersse Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UKFlex Lab A B 14 30 16 30Mouse Embryo Group Project discussion focus on the analysis of sequencing data and design optionsNeil Humphreys EMBL Rome Italy Michela Ascolani EMBL Rome Italy Alessandro Barenghi EMBL Rome Italy Isabel Rollan EMBL Heidelberg Germany Antony Adamson The University of Manchester UKTraining Lab A B16 30 17 00Coffee 17 00 18 00Lecture Imaged based high throughput screening RNAi vs CRISPRBeate Neumann EMBL Heidelberg Germany Courtyard Room18 00 20 30Pizza Dinner and Discussion round and drinks Ethical issues of CRISPR technology and genome engineeringRoof Top Lounge20 30 Bus from EMBL to ISG hotel EMBL bus stop Day 5 Thursday 21 September 2023 Time Europe Berlin SessionLocation08 30 08 45 Bus from ISG Hotel to EMBL 08 45 09 15Overview of the day 09 15 10 45Practical in GroupsMammalian Cell GroupGroup A Examine BFP cells via microscopy and FACSKristof Kersse Thermo Fisher Scientific GermanyKieran Van Kessel Thermo Fisher Scientific UK FACS Specialist Thermo FisherGroup B Knock In cell validation DNA PreparationBirgit Koch Max Planck Institute for Medical Research Germany Training Lab B09 15 10 45Mouse Embryo GroupThaw TLR2 embryos and examine KO and KI morular blastocysts for florescenceKnock In validation Neil Humphreys EMBL Rome Italy Michela Ascolani EMBL Rome Italy Maj Simonsen Jackson EMBL Rome Italy Isabel Rollan EMBL Heidelberg Germany Beate Neumann EMBL Heidelberg GermanyTraining Lab B10 45 11 15Coffee 11 15 12 45Practical in GroupsMammalian Cell GroupKnock In cell validation FACS AnalysisBirgit Koch Max Planck Institute for Medical Research GermanyCell Culture 116 Training Lab B11 15 12 45Mouse Embryo GroupImage embryosNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyALMF Facility12 45 13 45Lunch 13 45 15 00Practical in groupsMammalian cell groupKnock In cell validation Set up Junction PCRBirgit Koch Max Planck Institute for Medical Research GermanyNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyTraining Lab B 13 45 15 00 Mouse embryo groupTour of LAR Facility 15 00 15 30Break 15 30 16 30Lecture CRISPR Cas genome editing to generate transgenic miceNeil Humphreys EMBL Rome ItalyCourtyard Room16 30 18 30Technology Lounge Genome modification technologiesPresentation by different companies 18 45Bus from EMBL to downtown via ISG Hotel ATC entrance19 00Downtown course dinnerOskars Downtown Day 6 Friday 22 September 2023 Time Europe Berlin SessionLocation08 30 08 45 Bus from ISG Hotel to EMBL ISG Hotel08 45 09 15Overview of the dayCourtyard Room09 15 10 15Lecture Purification of Cas9 proteinKim Remans EMBL Heidelberg GermanyCourtyard Room10 15 11 15Practical in GroupsMammalian Cell GroupGel electrophoresis of junction PCRBirgit Koch Max Planck Institute for Medical Research GermanyTraining Lab B10 15 11 15Mouse Embryo GroupProject discussionNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyAlessandro Barenghi EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Montoya EMBL Heidelberg GermanyFlex Lab A B11 15 11 45Break11 45 12 45Practical in GroupsMammalian Cell GroupAnalysis of gel electrophoresisBirgit Koch Max Planck Institute for Medical Research GermanyTraining Lab B11 45 12 45Mouse Embryo GroupProject discussionNeil Humphreys EMBL Rome ItalyMichela Ascolani EMBL Rome ItalyMaj Simonsen Jackson EMBL Rome ItalyAlessandro Barenghi EMBL Rome ItalyIsabel Rollan EMBL Heidelberg GermanyFrank Montoya EMBL Heidelberg GermanyFlex Lab A B12 45 13 45Lunch13 45 15 00The Solution Room Last chance to ask questions Flex Lab A B 15 00 15 30Final discussions feedback session Flex Lab A B Practical Information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 790PhD Student 790Industry 1200 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events in Heidelberg and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO practical courses and workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Boehringer ingelheim fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Hotel Single rooms have been reserved for 5 nights 17 21 September 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code GEE23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors Event Partner Event Sponsor Event Supporter Media partners Medinformatics a Gold Open Access journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Neil Humphreys, Kristof Kersse, Birgit Koch, Elisabeth Zielonka

13 September 2023

Digital twins for drug repurposing by integrating mathematical modelling and machine learning: bridging the gap between in silico and real-world data

Description The rapid development of computational approaches has revolutionised the field of drug discovery and repurposing Here I will show a practical application of digital twins built by the synergistic combination of mathematical modelling of the cell and machine learning techniques to identify potential drug candidates for repurposing and subsequently validate their efficacy using real world data After discussing the inherent challenges associated with traditional drug discovery methods and the need for alternative approaches I will introduce the concept of digital twins virtual replicas of real biological systems which leverage mathematical models to capture the intricacies of cellular behaviour and response to drugs By integrating machine learning algorithms these digital twins can be trained on vast datasets to predict drug effectiveness and identify promising candidates for repurposing Moreover I will emphasise the importance of validating these predictions with real world data obtained from biomedical databases to ensure reliability and efficacy The presentation aims to showcase the power of integrating mathematical modelling digital twins and machine learning for drug repurposing paving the way for accelerated and cost effective drug discovery processes About the speaker Dr Joaqu n Dopazo is the director of the Computational Medicine Platform of Fundaci n Progreso y Salud He holds a degree in Chemistry and a PhD in Biological Sciences He has previously worked in public centres like the CIPF Valencia CNIO Madrid and companies like GlaxoWellcome SA Tres Cantos His field of work is personalised medicine with an approach that includes systems biology mathematical modelling and artificial intelligence areas in which he has published more than 350 articles...

Joaquín Dopazo

12 September - 15 September 2023

Developmental metabolism: flows of energy, matter, and information

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety recommendations if attending the on site event Overview The fundamental question of the role of metabolism in development has seen a revival in interest This is fueled by recent work shedding new light onto previously unrecognised roles of metabolism This work revealed the intricate relationship between energy flux spatial and temporal control of metabolites the environment and embryogenesis This emerging view is stimulating research designed to answer fundamental questions including How does the cellular machinery process information linked to the flow of energy and matter How does metabolic activity impact and constrain the emergence of form and function What are the physicochemical properties of developing systems Answering these questions requires interdisciplinary approaches including researchers from disparate fields such as developmental biology genetics epigenetics ecology physics and math Currently researchers engaged in the field lack a common platform The workshop Developmental metabolism flows of energy matter and information will create an intellectual space to exchange ideas across disciplines and help form a vibrant diverse community at the interphase between developmental biology molecular metabolism mathematics and physics Session Topics Physical bioenergetics Metabolic constraints in developing systems Metabolic control who got the power Metabolic signalling in time and space metabolites as morphogens Novel approaches and models to study metabolism in time and space Metabolic plasticity facing ever changing internal and external environments Intergenerational metabolic reprogramming the role of metabolism in offspring reprogramming Speakers V ronique Azuara Imperial College London UK Elvan B ke Centre for Genomic Regulation CRG Spain Ana Boskovic EMBL Rome Italy Carlos Carmona Fontaine New York University USA Richard Carthew Northwestern University USA Massimiliano Esposito The University of Luxembourg Luxembourg Nikta Fakhri Massachusetts Institute of Technology USA Virtual speaker Matthias Heinemann University of Groningen The Netherlands Constanze Kuhlisch Weizmann Institute of Science Israel Irene Miguel Aliaga Imperial College London UK Kristi Montooth University of Nebraska Lincoln USA Virtual speaker Samraat Pawar Imperial College London UK Virtual speaker Sider Penkov Technische Universit t Dresden Germany Olivier Pourqui Harvard Medical School USA Vanessa Wahl The James Hutton Institute United Kingdom Xingbo Yang Technische Universit t Dresden Germany Scientific organisers Alexander Aulehla EMBL Heidelberg Germany Heidi Lempradl Van Andel Institute USA Jonathan Rodenfels Max Planck Institute of Molecular Cell Biology and Genetics Germany Conference organiser Nathalie Sneider EMBL Heidelberg Germany Programme Got something to say Tweet it EMBODevMet Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk and the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Please find the poster listing here Day 1 Tuesday 12 September 2023 Time Europe Berlin Speaker12 30 14 00Registration and light refreshments14 00 14 10Opening remarks14 10 17 00Session 1 Chair Heidi Lempradl Van Andel InstituteUSA14 10 14 40Energy metabolism modulates the impact of regulators on developmental gene expressionRichard Carthew Northwestern University USA14 40 14 55Lactate and glycerol 3 phosphate metabolism cooperatively regulate larval growth in a tissue nonautonomous manner Madhulika Rai Indiana University Bloomington USA14 55 15 25How metabolism affects developmental transitions in plantsVanessa Wahl The James Hutton Institute UKNot available on demand15 25 16 00Coffee Break and Meet the speakers16 00 16 30Development of complex metabolic networks in fluctuating environments from ecosystem assembly to ontogenySamraat Pawar Imperial College London UK Virtual speaker 16 30 16 45Fueling the beginning of life the interplay between energy metabolism and cell biology during early developmentAnna K rte Max Planck Institute of Molecular Cell Biology and Genetics Germany16 45 17 00An unexpected metabolic switch occurs during sperm development requiring alternative metabolic fuel Guy Baziza The Hebrew University of Jeusalem Israel17 00 18 00Breakout session 1 Discussion in individual groups17 00 17 15 Scientific organisers meeting with group faciliatators participants to make their way to the section of the Helix reserved for their group 17 15 18 00 Group discussion18 00 19 30Poster Session 1 odd numbers 19 30 21 00Dinner in Canteen21 00 23 00Welcome reception Day 2 Wednesday 13 September 2023 Time Europe Berlin Speaker09 15 12 00Session 2Chair Sider Penkov Technische Universit t DresdenGermany09 15 09 45Non equilibrium physics in living systemsNikta Fakhri Massachusetts Institute of Technology USA Virtual speaker 09 45 10 00Mannose is crucial for mesoderm specification and symmetry breaking in gastruloids Chaitanya Dingare University of Cambridge UK10 00 10 30Thermodynamics of biochemical reaction networksMassimiliano Esposito University of Luxembourg Luxembourg10 30 11 00Coffee Break and Meet the speakers11 00 11 30Biophysics of energy metabolism in developmentXingbo Yang Technische Universit t Dresden Germany11 30 11 45Metabolic rewiring underpins human trophoblast induction Jan Zylicz Novo Nordisk Foundation Center for Stem Cell Medicine University of Copenhagen Denmark11 45 12 00Cellular estimation of morphogen concentration and gradients in developing tissues accurate decoding of molecular information in distributed cellular systems Krishnan Iyer National Centre for Biological Sciences India12 00 13 30Lunch and Meet the Editors13 30 16 00Session 3Chair Constanze Kuhlisch Weizmann Institute of Science Israel13 30 14 00Mechanisms underlying intergenerational metabolic effectsAna Boskovic EMBL Rome Italy14 00 14 15Metabolism dependent growth and limb regeneration in axolotls Moshe Khurgel Bridgewater College USA14 15 14 30Energy consumption and precision in cell cycles insights from a cell free microfluidics system Qiong Yang University of Michigan USANot available on demand14 30 15 15Coffee Break and Meet the speakers15 15 15 30A novel molecular axis consisting of ERK signalling SPIC links one carbon 1C metabolism to epigenetic regulation in embryonic stem cellsYaser Atlasi Queen s University Belfast UK15 30 16 00Metabolic flux dynamics and role on cell cycleMatthias Heinemann University of Groningen The Netherlands16 00 17 00Breakout session 2 Discussion in individual groups17 00 18 30Poster Session 2 even numbers 18 30 20 00Dinner in Canteen20 00 22 00All poster viewing and drinks Day 3 Thursday 14 September 2023 Time Europe Berlin Speaker09 15 12 00Session 4Chair Elvan B ke Centre for Genomic Regulation CRG Spain09 15 09 45How metabolic gradients pattern the tumor microenvironmentCarlos Carmona Fontaine New York University USANot available on demand09 45 10 00The role of metabolism during Hydra tissue patterning and regeneration Maryl ne Bonvin Friedrich Miescher Institute for Biomedical Research FMI University of Basel SwitzerlandNot available on demand10 00 10 30Metabolism and body axis formationOlivier Pourqui Harvard Medical School USA10 30 11 00Coffee Break and Meet the speakers11 00 11 30Eavesdropping on the metabolic crosstalk in marine algal bloomsConstanze Kuhlisch Weizmann Institute of Science Israel11 30 11 45Species specific tempo of neuronal development is driven by mitochondrial metabolism Ryohei Iwata VIB KU Leuven Belgium11 45 12 00Mitochondrial leak metabolism induces the Spemann Mangold Organizer via Hif 1 Alexandra MacColl Garfinkel Yale University USA12 00 13 30Lunch13 30 16 15Session 5Chair Jonathan Rodenfels Max Planck Institute of Molecular Cell Biology and GeneticsGermany 13 30 14 00Lipid storage trafficking and pluripotency during mammalian peri implantation developmentV ronique Azuara Imperial College London UK14 00 14 15Active Organelles How microbes leverage intracellular organelles to adapt migration strategies Anupam Sengupta University of Luxembourg Luxembourg14 15 14 30Understanding mitochondrial metabolism during development using the mitoMammal mitochondrial metabolic network model for human and mouse Bianca Habermann French National Centre for Scientific Research CNRS France14 30 15 00Consequences of mitochondrial nuclear interactions from genome evolution to metabolic plasticity and growthKristi Montooth University of Nebraska Lincoln USA Virtual speaker 15 00 15 30Coffee Break and Meet the speakers15 30 16 00The sex and geometry of inter organ communicationIrene Miguel Aliaga Imperial College London UKNot available on demand16 00 16 15Revealing the glycolysis Wnt signaling axis controlling the tempo of mouse embryonic development Hideonobu Miyazawa EMBL Heidelberg Germany16 15 17 15Breakout session 3 Discussion in individual groups17 15 17 45Coffee Break and Meet the speakers17 45 18 45Discussion Groups Summary18 45 20 15Conference dinner20 15 23 00Conference party with live music Day 4 Friday 15 September 2023 Time Europe Berlin Speaker09 15 11 45Session 6Chair Alexander Aulehla EMBL Heidelberg Germany 09 15 09 45Interwinding metabolic and developmental plasticity in C elegans how worms chose between growth and quiescenceSider Penkov Technische Universit t Dresden Germany09 45 10 00Continuous transcriptome and metabolome analysis reveals the relationship between gene expression and metabolism in early Drosophila embryos Jose Eduardo P rez Mojica Van Andel Institute USA10 00 10 15Interplay of redox and sugar sensing in Drosophila enteroendocrine cells Bohdana Rovenko University of Helsinki Finland10 15 10 45Coffee Break and Meet the speakers10 45 11 00Polyploidy in Xenopus lowers metabolic rate by decreasing total cell surface area Clotilde Cadart University of California Berkeley USANot available on demand11 00 11 15Connections between energy metabolism and morphogenesis in the developing lung Bezia Lemma Princeton University USA11 15 11 45Evading ageing Mitochondrial and proteostatic adaptations in oocytesElvan B ke Centre for Genomic Regulation CRG SpainNot available on demand11 45 12 00 Closing Remarks and Poster Prize12 00 12 15Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Name of CO for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Tuesday 15 August 2023 in some cases at special rates Please email the hotel directly quoting the booking code DMB23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses The bus schedule for this conference can be found here Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event hashtag as the password The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel information page Useful German expressions Where is the nearest Covid test centre Wo ist das n chste Covid Testzentrum HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie geht s I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Where is the nearest COVID 19 test centre Wo ist das n chste COVID 19 Testzentrum Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsor Cell ResearchEvent supporters Media partners International Union of Biochemistry and Molecular Biology Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Development a The Company of Biologists journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set 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Alexander Aulehla, Heidi Lempradl, Jonathan Rodenfels

10 September - 15 September 2023

Advanced methods in bioimage analysis

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This course will take place at EMBL Heidelberg Course overview Bioimage analysis has become a keystone of biological research the deluge of data produced by increasingly advanced microscopes calls for experts able to guide life scientists in the methods and software to be used to produce quantitative knowledge from this data Due to the complexity of the data without such expert guidance it is very likely that image analysis algorithms may be applied incorrectly possibly even producing erroneous results Moreover the diversity of imaging modalities analysis algorithms and software solutions is growing so rapidly that even experts are overwhelmed This advanced course concentrates on teaching cutting edge concepts and tools for quantitative image analysis and will seek to upgrade the competencies of future bioimage analysis experts on both theoretical algorithm advancements as well as on practical implementation skills Audience This course is aimed at early career scientists and staff scientists working in microscopy or image analysis facilities who already have experience in bioimage analysis Moreover participants should already provide or show a clear intent of providing bioimage analysis support to other researchers with less or no experience in bioimage analysis In selecting participants we look for scientific excellence immediate application of the methods learned motivation to disseminate and networking skills We expect a solid background in bioimage analysis and at least basic programming skills Modules resources Microscopy image quality control and image restoration Advanced image segmentation and complex cell phenotyping Handling large microscopy images such as whole slide scans and big N dimensional data Neural networks for image restoration segmentation and object classification Co localisation and spatial statistics Train the trainer how to teach image analysis Learning outcomes Participants should be able to apply what they have learnt to their own image data as well as to image data of their colleagues For each module participants will learn both theoretical and practical aspects of the latest developments in the fields of bio image analysis concepts and tools After this course they are expected to be able to confidently operate and interface with a representative selection of open and closed source image analysis software including Fiji QuPath ilastik morphographX KNIME Imaris and APEER in a reproducible and shareable manner In addition participants will gain new insights about how to set up an image analysis course in their own institution What past participants say about the course The EMBL practical course on Advanced Methods in Bioimage Analysis represents a turning point in my career As a Ph D student having the opportunity to meet network and learn with the most experienced researchers in this topic changed how I analyze my images and speed up my image analysis workflows Fernanda Garcia Fossa Institute of Biology University of Campinas Please see EMBL s COVID 19 safety recommendations for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Alex Bateman EMBL EBI UK Virtual Speaker Fynn Beuttenmueller EMBL Heidelberg Germany John Bogovic Janelia Research Campus USA Estibaliz G mez de Mariscal Instituto Gulbenkian de Ci ncia Portugal Robert Haase Max Planck Institute of Molecular Cell Biology and Genetics Germany Anna Klemm SciLifeLab and Uppsala University Sweden Anna Kreshuk EMBL Heidelberg Germany David Legland INRA France Kota Miura Freelance Image Analyst Japan Josh Moore German BioImaging e V Germany Perrine Paul Gilloteaux University of Nantes France Denis Schapiro Heidelberg University Hospital Germany Virginie Uhlmann EMBL EBI UK Carolina W hlby SciLifeLab and Uppsala University Sweden Jonas Windhager SciLifeLab and Uppsala University Sweden Scientific organisers Ignacio Arganda Carreras University of the Basque Country UPV EHU Spain Anna Klemm SciLifeLab and Uppsala University Sweden Perrine Paul Gilloteaux University of Nantes France Christian Tischer EMBL Heidelberg Germany Course organisers Catherine Casas Saavedra Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Officer EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOBioImage Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 10 September 2023 Time Europe Berlin SessionLocation12 45 13 00Bus from Hotel to EMBL ATC13 00 13 30Welcome and course overviewCourtyard Room A B13 30 15 00Networking activity Flash talks part 1 Courtyard Room A B15 00 15 30Coffee BreakCourtyard Room A B15 30 17 00Networking activity Flash talks part 2 Courtyard Room A B17 00 18 00Pre dinner networking only on site participants Courtyard Room A B18 00 19 00Dinner EMBL Canteen19 00 22 00Poster session only on site participants Helix B22 00Departure to HotelATC Entrance Day 2 Monday 11 September 2023 Time Europe Berlin SessionLocation08 40 08 55Bus from Hotel to EMBL ATC08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Live Q A to pre recorded lecture and introduction to practicalJosh Moore German BioImaging e V GermanyCourtyard Room A B10 00 10 15Coffee BreakCourtyard Room A B10 15 12 30Practical session 1 Image data managementJosh Moore German BioImaging e V GermanyComputer Training Lab12 30 13 00Debrief about the practicalComputer Training Lab13 00 14 30Lunch and short walk in the forestEMBL Canteen14 30 15 30Live Q A to pre recorded lecture Recent developments in the scientific python ecosystem for image analysis Robert Haase Max Planck Institute of Molecular Cell Biology and Genetics GermanyCourtyard Room A B15 30 16 00Coffee BreakCourtyard Room A B16 00 18 15Practical session 2 Recent developments in the scientific python ecosystem for image analysis Robert Haase Max Planck Institute of Molecular Cell Biology and Genetics GermanyComputer Training Lab18 15 18 45Debrief about the practicalComputer Training Lab18 45 20 15Dinner followed by networking only on site participants EMBL Canteen20 15Departure to HotelATC Entrance Day 3 Tuesday 12 September 2023 Time Europe Berlin SessionLocation08 40 08 55Bus from Hotel to EMBL ATC08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Live Q A to pre recorded chatGTP and practical introductionRobert Haase Max Planck Institute of Molecular Cell Biology and Genetics GermanyCourtyard Room A B10 00 10 15Coffee BreakCourtyard Room A B10 15 11 45Practical session 3 chatGTPRobert Haase Max Planck Institute of Molecular Cell Biology and Genetics GermanyComputer Training Lab11 45 12 15Debrief about the practicalComputer Training Lab12 15 13 00LunchEMBL Canteen13 00 13 15Group photoATC entrance13 15 14 15Live Q A to pre recorded lecture Advanced registration of big image data and practical introduction John Bogovic Janelia Research Campus USACourtyard Room A B14 15 14 30Coffee BreakCourtyard Room A B14 30 16 00Practical session 4 Advanced registration of big image dataJohn Bogovic Janelia Research Campus USAComputer Training Lab16 00 16 30Debrief about the practicalComputer Training Lab16 30 17 00Coffee BreakCourtyard Room A B17 00 21 00Software lounge with company booths Pizza sessionATC Rooftop Lounge21 00Departure to HotelATC Entrance Day 4 Wednesday 13 September 2023 Time Europe Berlin SessionLocation08 40 08 55Bus from Hotel to EMBL ATC08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Live Q A to pre recorded lecture Spatial omics data analysis and practical introduction Carolina W hlby Uppsala University SwedenCourtyard Room A B10 00 10 15Coffee BreakCourtyard Room A B10 15 12 30Practical session 5 Spatial omics data analysis Carolina W hlby Uppsala University SwedenComputer Training Lab12 30 13 00Debrief about the practicalComputer Training Lab13 00 14 00Lunch and short walk in the forest14 00 15 30Keynote lecture on spatial omics imagingDenis Schapiro Heidelberg University Hospital GermanyCourtyard Room A B15 30 15 45Coffee BreakCourtyard Room A B15 45 16 15Live Q A to pre recorded lecture National and international image data science networksPerrine Paul Gilloteaux University of Nantes FranceCourtyard Room A B16 15 16 45Live Q A to pre recorded lecture Data science as a service Anna Klemm Uppsala University SwedenCourtyard Room A B16 45 19 00Visit downtown Heidelberg19 00 21 00Course dinner downtownTBC Day 5 Thursday 14 September 2023 Time Europe Berlin SessionLocation08 40 08 55Bus from Hotel to EMBL ATC08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Live Q A to pre recorded lecture Standards for deep learning for segmentation and classification and practical introduction Anna Kreshuk EMBL Heidelberg GermanyCourtyard Room A B10 00 10 15Coffee BreakCourtyard Room A B10 15 12 00Practical session 6 Standards for deep learning for segmentation and classification Anna Kreshuk EMBL Heidelberg GermanyComputer Training Lab12 00 12 30Debrief about the practicalComputer Training Lab12 30 14 00Lunch and short walk in the forestEMBL Canteen14 00 15 00Lecture Deep learning principles pitfalls and perspectivesEstibaliz G mez de Mariscal Instituto Gulbenkian de Ci ncia PortugalCourtyard Room A B15 00 15 30Coffee BreakCourtyard Room A B15 30 16 30Lecture Responsible conduct of bioimage analysis research Kota Miura Freelance Image Analyst JapanCourtyard Room A B16 30 17 00Coffee BreakCourtyard Room A B17 00 18 00Virtual lecture Make your computing more environmentally sustainableAlex Bateman EMBL EBI UKCourtyard Room A B18 00 21 00BBQ at ISG Hotel followed by networking only on site participants ISG Hotel Day 6 Friday 15 September 2023 Time Europe Berlin SessionLocation08 40 08 55Bus from Hotel to EMBL ATC08 55 09 00Overview of the dayCourtyard Room A B09 00 10 00Live Q A to pre recorded lecture Advanced spline based shape quantification and practical introduction Virginie Uhlmann EMBL EBI UKCourtyard Room A B10 00 10 15Coffee BreakCourtyard Room A B10 15 12 00Practical session 7 Advanced spline based shape quantificationVirginie Uhlmann EMBL EBI UKComputer Training Lab12 00 12 30Debrief about the practicalComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 14 00Live Q A to pre recorded lecture Advanced image morphometry and practical demoDavid Legland INRA FranceCourtyard Room A B14 00 16 00Practical session 8 Advanced image morphometryDavid Legland INRA FranceComputer Training Lab16 00 16 30Debrief about the practicalComputer Training Lab16 30 17 00End of course discussionCourtyard Room A B Practical information Registration fees and motivation letter The course is limited to 20 onsite participants and 5 virtual For selection purposes please note that your application will not be considered without a letter of motivation Registration On site registration fees include admission course materials meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Virtual registration fees include access to live streamed course content lectures Q A sessions with speakers and trainers discussion rounds as well as virtual learning activities in the learning platform On site Academia 500On site PhD Student 500On site Industry 1000Virtual Academia 190Virtual PhD Student 190Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of 9 September to 15 September 2023 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room if available please let us know and please note that you will be required to pay an additional cost of 24 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the laboratories Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL Merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus Log in using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 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shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Map to walk from ISG Hotel to EMBL Additional information Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg Germany ATC orientation map Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page Technical requirements and event software delete the technical requirements part if it is not a computer based course in the courtyard room as well as change label of the details section to only Event Software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do 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Ignacio Arganda-Carreras, Anna Klemm, Perrine Paul-Gilloteaux, Christian Tischer

6 September - 10 September 2023

Protein synthesis and translational control

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPre conference workshop Overview For late registrations please contact Diah Yulianti at diah yulianti embl de This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Mechanisms that shape cellular proteomes are critical for life This conference focuses on the process of protein synthesis from the molecular and structural understanding of the translational machinery to its regulation its implications in cell and organismal biology and its alteration in disease The regulation of mRNA translation is critical to maintain cell homeostasis and mediates cellular responses to environmental physiological and pathological cues Given the central importance of protein synthesis it is unsurprising that dysregulation or defects in mRNA translation are widely linked to disease including cancer neurological or metabolic disorders and viral infection In recent years technical advances have challenged hitherto established dogmas uncovered new quality control mechanisms expanded the breath of translation regulators enhanced our understanding of the dynamics of translation in living cells and revealed unexpected interconnections with other cellular processes such as metabolism Advances on these aspects of mRNA translation will be featured as well as new insights into translation regulation in physiology and disease Session Topics Initiation Ribosome Elongation Methods Systems approaches Interconnections Turnover Metabolism Disease Viruses RNP plus RQC This conference is partnered with Cold Spring Harbor Laboratory CSHL Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speakers Rachel Green Johns Hopkins School of Medicine USA Venki Ramakrishnan MRC Laboratory of Molecular Biology UK Anne Willis University of Cambridge UK Speakers and session chairs Julie Aspden University of Leeds UK Hong Jin University of Illinois at Urbana Champaign USA Andr Gerber University of Surrey UK Vicent Pelechano SciLifeLab Karolinska Institutet Sweden Marvin Tanenbaum Hubrecht Institute The Netherlands Gabriella Viero Institute of Biophysics National Research Council CNR Italy Additional speakers will be selected from abstracts Scientific organisers Alfredo Castello University of Glasgow UK F tima Gebauer Centre for Genomic Regulation CRG Spain Matthias W Hentze EMBL Heidelberg Germany Jerry Pelletier McGill University Canada Christian Spahn Charit Berlin Germany Conference organiser Diah Yulianti EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLProtein For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 6 September 2023 Time Europe Berlin Speaker16 00 18 00Arrival Registration with light refreshmentsConference Bus schedule updated 31 Aug 16 30 17 30Pre conference workshop Ribosomes are decision hubs that control human embryonic cell fate trajectories by Immagina BioTechnology srl registration required 18 00 18 10Welcome remarks by the scientific organisers18 10 18 20John Hershey TributeChristopher S Fraser University of California USA18 20 19 05Keynote talk 1To be introduced by Alfredo Castello University of Glasgow UKFrom stress adaptation to off target immune response the physiological consequences of modified mRNAAnne Willis University of Cambridge UK19 05 19 50Keynote talk 2To be introduced by Christian Spahn Charit Berlin GermanyThe colliding ribosome as a hub for translational regulation and signaling activationRachel Green Johns Hopkins School of Medicine USA19 50 20 15Coffee break20 15 21 00Keynote talk 3To be introduced by Matthias W Hentze EMBL Heidelberg GermanyA human translational initiation complex suggests two independent roles for the helicase eIF4AVenki Ramakrishnan MRC Laboratory of Molecular Biology UK21 00 22 30Welcome reception with light refreshments Day 2 Thursday 7 September 2023 Time Europe Berlin Speaker09 00 12 30Session 1 Initiation09 00 09 10Introduction overview from session chairJulie Aspden University of Leeds UK09 10 09 30Head and Embryo 80S monosomes are much more translationally active than 80S in other tissuesJulie Aspden University of Leeds UKNot available on demand09 30 09 45Fine tuning the Integrated Stress Response through eIF2B regulation with small moleculesAlisa Zyryanova University of Cambridge UK09 45 10 00Human tumor suppressor protein Pdcd4 binds to the 40S to inhibit translation initiationJay Brito Querido University of Michigan Medical School USANot available on demand10 00 10 15eIF4F activity is specifically regulated to maintain stem cell self renewal in the Drosophila testis downstream of JAK STATRuoxu Wang UCL UK10 15 10 30Uncovering the rules between the translation of specific mRNAs and their requirements of eIF4A1 activity and functionTobias Schmidt Beatson Institute for Cancer Research UK10 30 11 00Coffee break11 00 11 15Translation Initiation in Hypoxia the case of the oncogene cateninAngelita Simonetti Universit de Strasbourg France11 15 11 30Ribosome queuing induced by a stem loop in the uORF2 ATF4 overlap represents yet another level of ATF4 translational controlAnna Smirnova Institute of Microbiology of the CAS Czech Republic11 30 11 45Mechanism of transcript specific translation repression by eIF3Fatima Alghoul Dana Farber Cancer Institute Harvard Medical School USA11 45 12 00Translating the translation process developing eIF1A inhibitors as a research tool and potential cancer therapyDaniel Hayat Weizmann Institute Israel12 00 12 15Structural pathway of human translation initiation from 43S PIC assembly to multi step 48S IC remodelingNiels Fischer Max Planck Institute for Multidisciplinary Sciences GermanyNot available on demand12 15 12 30Translation initiation at ambiguous start sites setting the right frameMatthias Erlacher Medical University of Innsbruck Austria12 30 14 00Lunch14 00 17 30Session 2 Ribosome Elongation14 00 14 10Introduction overview from session chairHong Jin University of Illinois at Urbana Champaign USA14 10 14 30From an ancient GTPase promoting protein synthesis in an evolutionarily conserved way to reconsidering translation pauses for control Hong Jin University of Illinois at Urbana Champaign USA14 30 14 45Elucidating novel mechanisms coordinating ribosome biogenesis across cellular compartmentsEliana Bianco ETH Z rich Switzerland14 45 15 00Mechanism of ribosome associated mRNA degradation during tubulin autoregulationMarkus H pfler MRC Laboratory of Molecular Biology UK15 00 15 15Nascent chain folding and transient polysome rearrangements orchestrate co translational protein complex assembly in bacteriaJir Koubek University of Heidelberg Germany15 15 15 30Co translational ribosome pairing enables native assembly of misfolding prone subunitsSander Tans AMOLF institute The NetherlandsNot available on demand15 30 16 00Coffee break Meet the speakers of Day 1 and Day 216 00 16 15Identification and characterization of novel quality control factors safeguarding co translational assembly pathwaysAyala Shiber Technion Israel Institute of Technology IsraelNot available on demand16 15 16 30rRNA expansion segments evolutionary tools to enhance translation accuracyRobert Rauscher University of Bern Switzerland16 30 16 45The molecular basis of tRNA selectivity by human pseudouridine synthase 3 PUS3 and its impact on mRNA translationLeon Kleemann University of Bern Switzerland16 45 17 00Ribosomal protein paralogues in germline developmentKatarina Grobicki University of Cambridge UK17 00 17 15mRNA selective functions of eIF3 in mRNA translation and cancerDieter Wolf Westlake University China17 15 17 30Translation factor eIF5A is the sensor and effector for autoregulation polyamine synthesisIvaylo Ivanov National Institutes of Health USA17 30 18 00Pre dinner drinks18 00 19 30Dinner19 30 21 30Poster session 1 odd numbers in ATC HelicesList of posters21 30 22 30Wine Cheese in ATC Rooftop Lounge Day 3 Friday 8 September 2023 Time Europe Berlin Speaker09 00 11 30Session 3 Methods Systems approaches09 00 09 10Introduction overview from session chairVicent Pelechano SciLifeLab Karolinska Institutet Sweden09 10 09 30Genomic dissection of co translational mRNA decay from metadegradome sequencing to genome wide frameshiftsVicent Pelechano SciLifeLab Karolinska Institutet Sweden09 30 09 45In vivo single cell ribosome profiling to investigate translational regulation in aged epidermal stem cellsClara Dur University of Zurich Switzerland09 45 10 00Measuring changes in translation efficiency with single cell ribosome profilingMichael VanInsberghe Hubrecht Institute KNAW Oncode Institute and University Medical Center Utrecht The Netherlands10 00 10 15CITePuro seq unlocking the secrets of immune cells plasticity with an innovative translatomic techniqueStefania Oliveto INGM Unimi ItalyNot available on demand10 15 10 45Coffee break10 45 11 00Comparative CRISPRi screens reveal cell context dependent quality control during mRNA translationGeraldine Rodschinka Max Planck Institute of Biochemistry GermanyNot available on demand11 00 11 15NaP TRAP seq uncovers changes in the regulatory activity of 5 UTRs on translation during early vertebrate developmentJean Denis Beaudoin University of Connecticut Health Center USA11 15 11 30Modeling tRNA determinants of codon translation efficiency in human cellsXavier Hernandez Alias Centre for Genomic Regulation Spain11 30 16 00Free time SightseeingSession 4 Interconnections Turnover16 00 16 10Introduction overview from session chairMarvin Tanenbaum Hubrecht Institute The Netherlands16 10 16 30Dissecting the translation elongation phase through ultra long tracking of individual ribosomesMarvin Tanenbaum Hubrecht Institute The Netherlands16 30 16 45Old dogmas revisited and reshaped A new view of the landscape of bacterial coupled transcription translationMikel Irastorza The Hebrew University of Jerusalem IsraelNot available on demand16 45 17 00Real time tracking of transcription translation couplingOlivier Duss EMBL Heidelberg GermanyNot available on demand17 00 17 15Structural basis of ribosomal 30S subunit degradation by RNase RHelge Paternoga University of Hamburg GermanyNot available on demand17 15 17 30Co translational intactions of importins with nascent nuclear cargoMaximilian Seidel Max Planck Institute of Biophysics Germany17 30 18 00Coffee break18 00 18 15Variant in EPRS1 mRNA from Hypomyelinating Leukodystrophy Patients Blocks m6A Modification at Variant distal Sites and Inhibits Nuclear Export and TranslationPaul Fox Lerner Research Institute Cleveland Clinic USA18 15 18 30LARP1 senses free ribosomal subunits to coordinate supply and demand of ribosomal proteinsJames Saba Johns Hopkins University School of Medicine USA18 30 18 45Hypoxia induced epigenetic changes coordinate transcription start site selection and translational control through remodeling of 5 UTRsKathleen Watt Karolinska Institutet Sweden18 45 19 00mRNA Location and Translation Rate Determine Protein Targeting to Dual DestinationsStavroula Mili National Cancer Institute NIH USA19 00 19 30Pre dinner drinks19 30 20 30Dinner20 30 22 30Poster session 2 even numbers in ATC HelicesList of posters22 30 23 30Wine Cheese in the ATC Foyer Day 4 Saturday 9 September 2023 Time Europe Berlin Speaker09 00 12 30Session 5 Metabolism Disease Viruses09 00 09 10Introduction overview from session chairGabriella Viero Institute of Biophysics National Research Council CNR Italy09 10 09 30Loss of interactions between SMN and ribosomes leads to the disruption of a multifunctional translation platform implications for Spinal Muscular AtrophyGabriella Viero Institute of Biophysics National Research Council CNR Italy09 30 09 45Regulation of poly A tail length and translation in oocytes and early embryosKehui Xiang Whitehead Institute for Biomedical Research USANot available on demand09 45 10 0028S rRNA fragment serves as biomarker for early cancer detectionRastislav Horos Hummingbird Diagnostics GmbH GermanyNot available on demand10 00 10 15Mitochondrial import of the F1 ATP synthase subunit ATP5A1 is enhanced by RNAAindrila Chatterjee EMBL Heidelberg Germany10 15 10 30Regulation of PINK1 translation via modulation of insulin and AMPK signaling to support mitophagy in neuronsJara Tabitha Hees Max Planck Institute for Biological Intelligence Germany10 30 11 00Coffee break11 00 11 15Discovery of factorless internal ribosome entry sites through metagenomic data miningNicolas Salcedo Porras The University of British Columbia Canada11 15 11 30Activation of an antiviral endonuclease RNase L alters the transcriptional landscape through changes in translation during innate immunityAgnes Karasik National Institutes of Health NIDDK USA11 30 11 45Universal features of Nsp1 mediated translational shutdown by coronavirusesEvangelos Karousis University of Bern Switzerland11 45 12 00Human MCTS1 dependent translation of JAK2is essential for IFN g immunity to mycobacteriaJonathan Bohlen Necker Hospital for Sick Children France12 00 12 15Blocking translation to rescue ALS FTD phenotypes associated with C9ORF72 repeat expansionFranck Martin University of Strasbourg CNRS France12 15 12 30Role of the RNA binding protein YBX3 in MesotheliomaAngela Rubio Tenor MRC Toxicology Unit UK12 30 14 00Lunch14 00 16 00Poster session 3 all numbers in ATC HelicesList of posters16 00 19 00Session 6 RNP plus RQC16 00 16 10Introduction overview from session chairAndr Gerber University of Surrey UK16 10 16 30Phosphofructokinase is a conserved RNA binding protein that modulates cell cycle progressionAndr Gerber University of Surrey UK16 30 16 45Large scale map of RNA binding protein interactomes across the mRNA life cycleLena Street Columbia University USA16 45 17 00eIF4E1b is a non canonical eIF4E required for maternal mRNA dormancyLaura Lorenzo Orts Institute of Molecular Pathology IMP Austria17 00 17 15Real time assembly dynamics of an mRNP translation repression complexMarco Payr EMBL Heidelberg Germany17 15 17 30The multifaceted role of FMRP translational repression ribosome stalling and potential implications for mRNA degradation via the no go decay pathwayMaKenzie Scarpitti The Ohio State University USA17 30 17 45Ribosome collision underlies ZAKalpha mediated inflammation and programmed cell death in UV irradiated skinSimon Bekker Jensen University of Copenhagen Denmark17 45 18 15Coffee Break Meet the speakers of Day 3 and Day 418 15 18 30Sequence context and ribosomal collisions affect the suppressor tRNA efficiencyNikhil Bharti University of Hamburg Germany18 30 18 45Molecular basis of eIF5A dependent CAT tailing in eukaryotic ribosome associated quality controlPetr Tesina CEITEC MU Czech RepublicNot available on demand18 45 19 00Ubiquitin code for helicase driven clearance of colliding ribosomesToshifumi Inada The University of Tokyo Japan19 00 19 15The helicase HrpA splits stalled ribosomes in E coliAnnabelle Campbell Johns Hopkins University USA19 15 19 30Power naps a new mechanism of bacterial ribosome hibernationSergey Melnikov Newcastle University UK19 30 19 45Closing remarks19 45 21 30Conference Dinner21 30 00 30Conference Party Day 5 Sunday 10 September 2023 Departure day Practical information Registration fees and abstract submission For late registrations please contact Diah Yulianti at diah yulianti embl de On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 775On site PhD Student 675On site Industry 975Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact diah yulianti embl de for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until Monday 7 August 2023 in some cases at special rates Please email the hotel directly quoting the booking code TRC23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel Here are the shuttle bus times Updated 31 August for this conference View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual Participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Silver sponsor Media partners EMBO Journal an EMBO Press journal International Union of Biochemistry and Molecular Biology FEBS Journal a FEBS Press journal FEBS Letters a FEBS Press journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 Pre conference workshop For on site participants only This industry webinar will be hosted by our sponsor Immagina BioTechnology srl prior to the EMBL Conference Protein synthesis and translational control on Wednesday 6 September 2023 16 30 17 30 Participation in this workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served All registered conference attendees will receive an email with a registration link in the beginning of August ABSTRACT Ribosomes are decision hubs that control human embryonic cell fate trajectories Prof Leo KurianUniversity of Cologne Germany The blueprints of developing organs are preset at the early stages of embryogenesis Transcriptional and epigenetic mechanisms are proposed to preset developmental trajectories However we reveal that the competence for the future cardiac fate of human embryonic stem cells hESCs is preset in pluripotency by a specialized mRNA translation circuit controlled by RBPMS RBPMS is recruited to active ribosomes in hESCs to control the translation of essential factors needed for cardiac commitment program including Wingless Integrated WNT signaling Consequently RBPMS loss specifically and severely impedes cardiac mesoderm specification leading to patterning and morphogenetic defects in human cardiac organoids Mechanistically RBPMS specializes mRNA translation selectively via 3 UTR binding and globally by promoting translation initiation Accordingly RBPMS loss causes translation initiation defects highlighted by aberrant retention of the EIF3 complex and depletion of EIF5A from mRNAs thereby abrogating ribosome recruitment We demonstrate how future fate trajectories are programmed during embryogenesis by specialized mRNA translation...

Alfredo Castello, Fátima Gebauer, Matthias Hentze, Jerry Pelletier,Christian Spahn

24 July - 4 August 2023

Plasticity in developing systems: time, space, and environment

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course Overview Studying organisms in their original context and environment is one of the current grand challenges in the life sciences and a central goal of modern Developmental Biology The interactions between organisms and their chemical physical and biotic environments have important consequences at the level of form physiology and behaviour To gain an understanding and uncover mechanistic links between these interconnected and dynamic processes novel interdisciplinary approaches and cutting edge technologies are needed The aim of this course is to expose and introduce graduate students and postdoctoral fellows to fundamental questions and challenges related to the study of how the dynamic interplay between organisms and their changing environment impacts developmental processes and evolutionary novelty The participating students will benefit from a well balanced curriculum with lectures and hands on practicals We invite external keynote speakers each day of the course covering different topics related to how environmental factors control development physiology and behaviours and emphasising developmental plasticity timing and metabolism Each afternoon EMBL groups will run lab practicals in a wide range of organisms i e bacterial colonies Dictyostelium algae plants Nematostella worms flies vertebrates Most experiments will be centered around the common theme of Organisms interacting with their environment Audience This course is intended for graduate students and post doctoral fellows with a STEM background We aim to balance the number of participants with hands on experience and theoretical background Modules Studying collective behaviors of soil derived Dictyostelium and Bacilli species Metabolic control of developmental timing in mouse and medaka embryos Studying the role of behaviour in development of Nematostella vectensis 4D imaging of development Single cell sorting of diatom symbiosis from the natural environment Molecular dissection of brain pioneer cell morphogenesis in C Elegans Phenotypic plasticity of the planarian flatworms Exploring animal development and evolution with synthetic biology in Drosophila Melanogaster Imaging of cellular bases of root formation in the model plant Arabidopsis thaliana using a SPIM microscope Biophysical properties of embryonic tissues in zebrafish Learning outcomes The course will provide 1 an introduction to modern developmental biology questions covering a broad spectrum of developing systems 2 hands on experiments and data analysis in a variety of model and non model organisms Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Keynote speakers Susana Coelho Max Planck Institute for Biology T bingen Germany Scott Gilbert Swarthmore College USA Alexander Jones University of Cambridge UK Ant nia Monteiro National University of Singapore Singapore Manu Prakash Stanford University USA Jonathan Rodenfels Max Planck Institute of Molecular Cell Biology and Genetics Germany Kristin Tessmar Max Perutz Labs Vienna Austria Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research and Carl von Ossietzky University Germany Speakers and trainers Alexander Aulehla EMBL Heidelberg Germany Justin Crocker EMBL Heidelberg Germany Thomas Greb Heidelberg University Germany Aissam Ikmi EMBL Heidelberg Germany Nicoletta Petridou EMBL Heidelberg Germany Robert Prevedel EMBL Heidelberg Germany Georgia Rapti EMBL Heidelberg Germany Jordi van Gestel EMBL Heidelberg Germany Flora Vincent EMBL Heidelberg Germany Hanh Vu EMBL Heidelberg Germany Timo Zimmermann EMBL Heidelberg Germany Trainers LabPeopleAulehla Sapna Chhabra EMBL Heidelberg GermanySimon Knoblich EMBL Heidelberg Germany CrockerLautaro Gandara EMBL Heidelberg GermanyNikolaus Vlachopoulos EMBL Heidelberg GermanyGrebPascal Hunziker Heidelberg University GermanyKiara Kaeufer Heidelberg University GermanyJiao Zhao Heidelberg University GermanyIkmiFlorian Gabler EMBL Heidelberg GermanyLevin Riedel EMBL Heidelberg GermanyPetridouCristina Pallares Cartes EMBL Heidelberg GermanyCamilla Autorino EMBL Heidelberg GermanyLaura Rustarazo Calvo EMBL Heidelberg GermanyMagdalena Schindler EMBL Heidelberg GermanyPrevedel ZimmermannSamuel Davis EMBL Heidelberg GermanyRory Power EMBL Heidelberg GermanyRaptiFrancesca Caroti EMBL Heidelberg GermanyLaura Sabou EMBL Heidelberg Germanyvan GestelMireia Garriga Canut EMBL Heidelberg GermanyAndrea Zanon EMBL Heidelberg GermanyVincentKevin Moog EMBL Heidelberg GermanyThomas Beavis EMBL Heidelberg GermanyMoritz Winker EMBL Heidelberg GermanySoraya Zwahlen EMBL Heidelberg GermanyVuKristina Mirkes EMBL Heidelberg GermanyAna Mellado Fuentes EMBL Heidelberg GermanyAmrutha Palavalli EMBL Heidelberg GermanyGaurav Vaidya EMBL Heidelberg GermanyDB unit Microscopy supportMatt Benton Scientific organisers Alexander Aulehla EMBL Heidelberg Germany Aissam Ikmi EMBL Heidelberg Germany Nicoletta Petridou EMBL Heidelberg Germany Alessandra Reversi EMBL Heidelberg Germany Course organiser Swetlana Krez EMBL Heidelberg Germany Nathalie Sneider EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOPlasticity Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Monday 24 July 2023 Time Europe Berlin SpeakerLocation08 40 Bus from ISG Hotel to EMBL Operon entranceISG Hotel bus stop09 00 09 30Welcome house notes and safety instructionsLarge Operon09 30 10 30Networking activityLarge Operon10 30 11 00Coffee BreakOperon Foyer11 00 12 00Introduction to practical 1Jordi van Gestel EMBL Heidelberg GermanyLarge Operon12 00 13 00LunchEMBL Canteen13 00 14 00Field trip to collect samplesDepart Operon Foyer14 00 17 00Practical 1 Studying collective behaviors of soil derived Dictyostelium and Bacilli speciesJordi van Gestel and members of his lab EMBL Heidelberg GermanyTraining Lab B17 00 18 00Keynote Lecture 1 Environment and the origins of complex behaviour in biological systemsManu Prakash Stanford University USALarge Operon16 00 19 00Networking Meet the speaker with Manu Prakash Stanford University USAOperon Foyer19 00 20 00DinnerEMBL Canteen20 00 22 00Poster session 1Operon Foyer22 00Departure to ISG Hotel and end of Day 1ATC entrance Day 2 Tuesday 25 July 2023 Time Europe Berlin SpeakerLocation09 15Bus from ISG to EMBLISG Hotel bus stop09 30 09 35Overview of the dayCourtyard A 09 35 10 30Keynote Lecture 2 The developmental biology of holobiontsScott Gilbert Swarthmore College USALarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Networking Meet the speaker Scott Gilbert Swarthmore College USAOperon Foyer12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 2Flora Vincent EMBL Heidelberg GermanyCourtyard Room A B14 00 18 00Practical 2 Single cell sorting of diatom symbiosis from the natural environmentFlora Vincent and members of her lab EMBL Heidelberg GermanyTraining Lab B18 00 19 00DinnerEMBL Canteen19 00 21 00Poster session 2Operon Foyer21 00Departure to ISG Hotel and end of Day 2ATC entrance Day 3 Wednesday 26 July 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop09 30 09 35Overview of the dayLarge Operon09 35 10 30Keynote Lecture 3 Evolution of a mechanism of plasticity in eyespot wing patternsAntonia Monteiro National University of Singapore SingaporeLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Networking Meet the speaker with Antonia Monteiro National University of Singapore SingaporeLarge Operon12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 3Justin Crocker EMBL Heidelberg GermanyCourtyard Room A B14 00 18 00Practical 3 Exploring animal development and evolution with synthetic biology in Drosophila MelanogasterJustin Crocker and members of his lab EMBL Heidelberg GermanyTraining Lab B18 00 19 00DinnerEMBL Canteen19 00Continued networking Operon Foyer19 45Departure to ISG Hotel end of Day 4ATC entrance Day 4 Thursday 27 July 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop09 30 09 35Overview of the dayLarge Operon09 35 10 30Keynote Lecture 4 The effect of variation in light in the biological processesKristin Tessmar Max Perutz Labs Vienna AustriaLarge Operon10 30 11 00Coffee BreakOperon Foyer11 00 12 00Networking Meet the speaker with Kristin Tessmar Max Perutz Labs Vienna AustriaLarge Operon12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 4Hanh Vu EMBL Heidelberg GermanyLarge Operon14 00 18 00Practical 4 Phenotypic plasticity of the planarian flatwormsHanh Vu and members of her lab EMBL Heidelberg GermanyTraining Lab B18 00 19 00Dinner19 00 21 00Round Table discussion Responsible conduct of researchATC Rooftop Lounge21 00Departure to ISG Hotel end of Day 4ATC entrance Day 5 Friday 28 July 2023 Time Europe Berlin SpeakerLocation08 40 Bus from the ISG Hotel to EMBLISG Hotel bus stop09 00 09 05Overview of the dayCourtyard Room A B09 05 10 00Introduction to practical 5Nicoletta Petridou EMBL Heidelberg GermanyCourtyard Room A B10 00 12 00Practical 5 part 1 Biophysical properties of embryonic tissues in ZebrafishNicoletta Petridou and members of her lab EMBL HeidelbergTraining Lab B12 00 13 00LunchEMBL Canteen13 00 18 00Practical 5 part 2 Biophysical properties of embryonic tissues in ZebrafishNicoletta Petridou and members of her lab EMBL HeidelbergTraining Lab B18 00 19 00Dinner19 00 21 00Data analysis practical 5Computer Training Lab21 00Departure to ISG Hotel end of Day 5ATC entrance Day 6 Saturday 29 July 2023 Time Europe Berlin SpeakerLocation09 15Bus from ISG to EMBLISG Hotel bus stop09 30 09 35Overview of the dayLarge Operon09 35 10 30Keynote Lecture 5 The energetic cost of early development in their environmentJonathan Rodenfels Max Planck Institute of Molecular Cell Biology and Genetics GermanyLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Networking Meet the speaker with Jonathan Rodenfels Max Planck Institute of Molecular Cell Biology and Genetics GermanyOperon Foyer12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 6Alexander Aulehla EMBL Heidelberg GermanyAissam Ikmi EMBL Heidelberg GermanyCourtyard Room A B14 00 18 00Practical 6 Metabolic control of developmental timingAlexander Aulehla and members of his lab EMBL Heidelberg GermanyAissam Ikmi and members of his lab EMBL Heidelberg GermanyTraining Lab B18 00 19 00DinnerEMBL Canteen19 00 19 45Continued networkingOperon Foyer19 45Departure to ISG Hotel end of Day 6ATC entrance Day 7 Sunday 30 July 2023 Free Day Day 8 Monday 31 July 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop09 30 09 35Overview of the dayLarge Operon09 35 10 30Keynote Lecture 6 The life cycle and reproduction of brown algaeSusana Coehlo Max Planck Institute for Biology T bingenLarge Operon10 30 11 00Coffee BreakOperon Foyer11 00 12 00Networking Meet the speaker with Susana Coehlo Max Planck Institute for Biology T bingenLarge Operon12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 7Georgia Rapti EMBL Heidelberg GermanyCourtyard Room A B14 00 18 00Practical 7 Molecular dissection of brain pioneer cell morphogenesis in C ElegansGeorgia Rapti and members of her lab EMBL Heidelberg GermanyTraining Lab B18 00 19 00DinnerEMBL Canteen19 00 19 45Continued networking Operon Foyer19 45Departure to ISG Hotel end of Day 8ATC entrance Day 9 Tuesday 1 August 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop09 30 09 35Overview of the dayComputer Training Lab09 35 10 30Data Analysis Practical 6 7Computer Training Lab10 30 11 00Coffee BreakOperon Foyer11 00 12 00Data Analysis Practical 6 7Computer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 8Robert Prevedel EMBL Heidelberg GermanyCourtyard Room A B14 00 18 00Practical 8 4D imaging of developmentRobert Prevedel and Timo Zimmermann EMBL Heidelberg GermanyTraining Lab B18 00 19 00Dinner19 00 21 00Round Table discussion Responsible conduct of researchATC Rooftop Lounge21 00Departure to ISG Hotel end of Day 9ATC entrance Day 10 Wednesday 2 August 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop 09 30 09 35Overview of the dayLarge Operon09 35 10 30Keynote Lecture 7 Plant development and physiologyAlexander Jones University of Cambridge UKLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Networking Meet the speaker with Alexander Jones University of Cambridge UKLarge Operon12 00 13 00LunchEMBL Canteen13 00 14 00Introduction to practical 9Thomas Greb Centre for Organismal Studies Uni Heidelberg HeidelbergCourtyard Room A B14 00 18 00Practical 9 Plant development and physiologyThomas Greb and member of his lab Centre for Organismal Studies Uni Heidelberg HeidelbergTraining Lab B18 00 19 00Dinner19 00 21 00Group activity Data analysis of practicals 9Computer Training Lab21 00Departure to ISG Hotel end of Day 10ATC entrance Day 11 Thursday 3 August 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop09 30 09 35Overview of the dayCourtyard Room A B09 35 10 30Follow up on the field trip samplesCourtyard Room A B10 30 11 00Coffee BreakCourtyard Room A B11 00 12 00Time to prepare the presentationCourtyard Room A B12 00 13 00LunchEMBL Canteen13 00 15 00Time to prepare the presentationsCourtyard Room A B15 00 15 30Coffee BreakCourtyard Room A B15 30 17 30Presentations by the participantsLarge Operon18 00 22 00BBQ and PartyOperon Foyer and Terrace22 00Departure to ISG Hotel end of Day 11ATC entrance Day 12 Friday 4 August 2023 Time Europe Berlin SpeakerLocation09 15Bus from the ISG Hotel to EMBLISG Hotel bus stop09 30 09 35Overview of the dayLarge Operon09 35 10 30Final remarksLarge Operon10 30 11 00Coffee breakOperon Foyer11 00 12 00Closing wrap up and feedback sessionLarge Operon12 00 13 00LunchEMBL Canteen13 00Departure ATC entrance Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of Sunday 23 July to 4 August 12 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 24 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event Sponsor Event Supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations PPT Slide 16 9 Social 1080 1920 Social 1080 1080 Social 1600 900...

Alexander Aulehla, Aissam Ikmi, Nicoletta Petridou, Alessandra Reversi

18 July - 21 July 2023

Theory and concepts in biology

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Recent progress in biology has led to an explosion of factual knowledge about the living world over a huge range of scales in space and time Yet many questions about how to make sense of this data remain across the entire diversity of the living world from the smallest bacterium to the ecosystems of the Serengeti This meeting aims to bring together a diverse collection of researchers interested in finding ways to parlay this ever increasing factual knowledge into a corresponding array of conceptual knowledge The goal of this symposium is to assemble an interdisciplinary community and to provide a platform to discuss perspectives on the role of theory in biology and importantly also vice versa the impact that biology can have on theory Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Francis Corson Laboratoire de Physique de l Ecole Normale Sup rieure France J rn Dunkel Massachusetts Institute of Technology USA Anna Erzberger EMBL Heidelberg Germany Paul Fran ois Universit de Montr al Canada Raymond Goldstein University of Cambridge UK Christina Hueschen Stanford University USA Frank J licher Max Planck Institute for the Physics of Complex Systems Germany Jan Kondev Brandeis University USA Aneta Koseska Max Planck Institute for neurobiology of behaviour Caesar Germany Rita Mateus Max Planck Institute of Molecular Cell Biology and Genetics and Cluster of Excellence Physics of Life Germany Yasmine Meroz Tel Aviv University Israel Sriram Rajagopal Ramaswamy Indian Institute of Science India Chao Tang Center for Quantitative Biology Peking University China Evelyn Tang Rice University USA Kirsty Wan University of Exeter UK Scientific organisers Alexander Aulehla EMBL Heidelberg Germany Rob Phillips California Institute of Technology USA Jordi Garcia Ojalvo Pompeu Fabra University UPF Spain Kirsty Wan University of Exeter UK Conference organisers Charlotte Courtney EMBL Heidelberg Germany Programme Got something to say Tweet it EESTCBio Please note that the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 18 July 2023 Time Berlin Europe Speaker11 30 13 00Registration and light refreshments13 00 17 00Chair Jordi Garcia Ojalvo13 00 13 15Opening remarks13 15 13 45Flocking across scales from wildebeest to parasite actinChristina Hueschen Stanford University USA13 45 14 15Fast and cirri ous excitable dynamics in protistsKirsty Wan University of Exeter UKNot available on demand14 15 14 30Coarse grained representations of transcriptional enhancersJoseph Nasser Harvard University USA14 30 14 45A lack of distinct cell identities in single cell measurements revisiting Waddington s landscapeBreanne Sparta University of California Los Angeles USA14 45 15 30Coffee Break and Meet the speakers of Day 1Francis Corson Frank J licher Christina Hueschen Kirsty Wan15 30 16 00Flowing into shape self organized patterning and morphogenesisFrancis Corson Laboratoire de Physique de l Ecole Normale Sup rieure France16 00 16 15Are circadian amplitudes and periods correlated A new twist in the storyMarta del Olmo Humboldt University of Berlin Germany16 15 16 30Anchoring behavior affected by geometrical cues in the ciliate Stentor coeruleusSyun Echigoya Hokkaido University Japan16 30 17 00Active Processes in Cells and TissuesFrank J licher Max Planck Institute for the Physics of Complex Systems Germany17 00 17 30Group activity allocationOn site participants only17 30 18 30Pre dinner drinks18 30 20 00Dinner20 00 22 00Group activity Day 2 Wednesday 19 July 2023 Time Berlin Europe Speaker09 00 09 15Arrival and coffee09 15 10 15Chair Virginie Uhlmann09 15 09 45Growth control across scalesRita Mateus Max Planck Institute of Molecular Cell Biology and Genetics and Cluster of Excellence Physics of Life Germany09 45 10 00A general limit for the sharpness of input output responses grounds the Hill function in biophysical mechanismRosa Martinez Corral Centre for Genomic Regulation Spain10 00 10 15Critical points in embryonic tissue organisationNicoletta Petridou EMBL Heidelberg Germany10 15 10 45Coffee Break and Meet the Editors session10 45 12 15Chair Francis Corson10 45 11 15The Scale Invariant CellJan Kondev Brandeis University USA11 15 11 30A feedback motif to increase sensitivity and information integration in sensory systemsIsabella Graf11 30 11 45Deriving a phase diagram structure of signaling systems with the optimal trade off between sensitivity and precisionKa Kit Kong Peking University China11 45 12 15Topology protects emergent dynamics in biological networksEvelyn Tang Rice University USA12 15 14 15Lunch14 15 16 45Chair Nicoletta Petridou14 15 14 30Theory EMBL bringing theoretical approaches closer to experimental biologyVirginie Uhlman EMBL EBI UK14 30 15 00Non reciprocal interactions and waves without density in flocks on manifoldsSriram Rajagopal Ramaswamy Indian Institute of Science India15 00 15 15Integration of contradictory signals in epithelial to mesenchymal transitionYaron Antebi Weizmann Institute of Science Israel15 15 15 30The Core Periphery hypothesis a conceptual basis for generality in cell and developmental biologyJonas Hartmann University College London UK15 30 16 00Scaling dictates the decoder structureChao Tang16 00 16 45Coffee Break and Meet the speakers of Day 2Rita Mateus Jan Kondev Sriram Ramaswamy Chao Tang Evelyn Tang16 45 17 30Group activity On site participants only17 30 19 00Poster Session 1 odd with beer and snacks19 00 20 30Dinner20 30 22 30After dinner drinks Day 3 Thursday 20 July 2023 Time Berlin Europe Speaker09 00 09 15Arrival and coffee09 15 10 15Chair Jan Kondev09 15 09 45Model inference for living matter from biological data to dynamical equationsJ rn Dunkel Massachusetts Institute of Technology USA09 45 10 00Understanding feedback control in biological systemsMariana G mez Schiavon The National Autonomous University of Mexico Mexico10 00 10 15Inferring the stochastic dynamics of cell shape changes during cellular state transitionsWolfram Ponisch University of Cambridge UK10 15 10 45Coffee Break10 45 12 45Chair Aneta Koseska10 45 11 15Plant Tropisms as a Window on Plant Computational ProcessesYasmine Meroz Tel Aviv University Israel11 15 11 30Topology and Geometry Together in BiologyCarl Modes Max Planck Institute of Molecular Cell Biology and Genetics Germany11 30 11 45The noisy physical cell Vast heterogeneity in cytoplasmic diffusion rates revealed by nanorheology and Doppelg nger simulationsRikki Garner Harvard Medical School USA11 45 12 15Surface dynamics in living systemsAnna Erzberger EMBL Heidelberg Germany12 15 12 45Does Biological Research Require a Hypothesis Raymond Goldstein University of Cambridge UK12 45 14 15Lunch14 15 15 45Group activity HikeOn site participants only15 45 16 15Coffee Break and Meet the speakers of Day 3J rn Dunkel Yasmine Meroz Anna Erzberger Raymond Goldstein16 15 17 30Group activity presentationsOnly for on site participants to present but presentations will be live streamed to virtual participantsChair Kirsty Wan17 30 19 00Poster Session 2 even with beer and snacks19 00 20 30Conference BBQ dinner20 30 23 00Conference party Day 4 Friday 21 July 2023 Time Berlin Europe Speaker09 00 09 15Arrival and coffee09 15 12 15Chair Alexander Aulehla09 15 09 45Basis of natural computationsAneta Koseska Max Planck Institute for neurobiology of behaviour Caesar Germany09 45 10 00Dynamic instability of cell like compartmentsJan Brugues Technische Universit t Dresden Germany10 00 10 30Latent Space modelling of biological dynamicsPaul Francois Universit de Montr al Canada10 30 11 15Coffee Break and Meet the speakers of Day 4Hana El Samad Paul Francois Aneta Koseska11 15 11 30A mechanochemical model for symmetry breaking in regenerating Hydra as alternative to a purely biochemical reaction diffusion modelSera Weevers Friedrich Miescher Institute for Biomedical Research Switzerland11 30 11 45Robust speed of biochemical waves reveals a general scaling relationshipJo Hsi Huang Stanford University School of Medicine USA11 45 12 00Closing Remarks and Poster Prize12 00 13 00Final conference lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Charlotte Courtney for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Tuesday 20th June 2023 in some cases at special rates Please email the hotel directly quoting the booking codeEES23 07 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Here is the conference shuttle bus timetable for this conference Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions Where is the nearest Covid test centre Wo ist das n chste Covid Testzentrum HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Development a The Company of Biologists journal EMBO reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Alexander Aulehla, Jordi Garcia-Ojalvo, Robert Phillips. Kirsty Wan

18 July - 20 July 2023

Open Virtual Ensembl REST API Workshop

Description Work with Ensembl to master the Ensembl REST API and flexibly access genome wide data such as genes variants regulatory features homologues and alignments...

Louisse Paola Mirabueno

16 July - 21 July 2023

Drosophila genetics and genomics

Description OverviewSpeakersOnsite programmeVirtual programmePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview The fruit fly Drosophila has played a leading role in the discovery and dissection of basic biological processes uncovering general principles of development evolution and disease Almost a century of research has generated a powerful genetic toolbox that provides a unique arsenal of methods that can tackle almost any biological question This combined with exciting new technologies developed in recent years have changed the way Drosophila research is conducted enabling biologists to address questions that were impossible to study before The course has three main objectives First to educate and inspire the next generation of scientists by providing an up to date overview and hands on training of contemporary and classic topics spanning state of the art techniques in genetics imaging and genomics Participants will obtain an essential knowledge base combined with practical training forming a launch pad for their research Second to stimulate the exchange of ideas between established and early career scientists enabling participants to better direct their research trajectory Third to provide networking opportunities hence fostering collaborations and career development The new course combines 50 interactive theoretical discussions that have been successfully used to train generations of Drosophila researchers for nearly 30 years combined with 50 new practical hands on cutting edge experiments taught by experts in the field Audience The course is aimed at PhD students and early stage post doctoral researchers who want to start using or enhance their knowledge of Drosophila as a model organism Modules Drosophila anatomy development genetics and outreach advocacy CRISPR design in flies Live imaging in the fly Genomics at single cell resolution Drosophila behavioural analysis Analysis of fly infection Drosophila diversity and evolution Learning outcomes Training session will familiarize attendees with classical and modern approaches to fruit fly genetics and genomics including EMS screens and CRISPR gene editing modern imaging methods behavioural analysis immunity assays and handling wild caught species Speakers Speakers trainers and staff Baptiste Alberti Institute of Functional Genomics of Lyon France Saudat Alishayeva The Friedrich Miescher Laboratory Germany Matthew Benton EMBL Heidelberg Germany Noa Borst EMBL Heidelberg Germany Justin Crocker EMBL Heidelberg Germany Marc Freeman Vollum Institute USA Eileen Furlong EMBL Heidelberg Germany Lautaro Gandara EMBL Heidelberg Germany Hernan Garcia University of California Berkeley USA Yad Ghavi Helm Institute of Functional Genomics of Lyon France Nicolas Gompel Ludwig Maximilians Universit t M nchen Germany Scott Gratz Brown University USA Amanda Larracuente University of Rochester USA Xueying Li EMBL Heidelberg Germany Audrey Medeiros Brown University USA Migla Miskinyte Instituto Gulbenkian de Ci ncia Portugal Kate O Connor Giles Brown University USA Luisa Pallares The Friedrich Miescher Laboratory Germany Mindy Perkins EMBL Heidelberg Germany Ella Preger Ben Noon Technion Israel Institute of Technology Israel Andreas Prokop The University of Manchester UK Julie Simpson University of California Santa Barbara USA James Tan Sheng Yi The Friedrich Miescher Laboratory Germany Lu s Teixeira Cat lica Biomedical Research Centre and Instituto Gulbenkian de Ci ncia Portugal Natascha Turetzek Ludwig Maximilians Universit t M nchen Germany Harald V hringer EMBL Heidelberg Germany Robert Patrick Zinzen Max Delbr ck Center Germany Scientific organisers Justin Crocker EMBL Heidelberg Germany Kate O Connor Giles Brown University USA Ella Preger Ben Noon Technion Israel Institute of Technology Israel Andreas Prokop The University of Manchester UK Course organisers Catherine Casas Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Officer EMBL Heidelberg Germany Onsite programme Got something to say Tweet it EMBODrosophila Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 16 July 2023 Time Europe Berlin SessionLocation14 30 15 00Bus from hotel to EMBL ATC entranceB B Hotel15 00 15 30Registration and light refreshmentsCourtyard Room A B15 30 15 40Welcome introduction and housenotesJustin Crocker EMBL Heidelberg GermanyKate O Connor Giles Brown University USAElla Preger Ben Noon Technion Israel Institute of Technology IsraelAndreas Prokop The University of Manchester UKCourtyard Room A B15 40 15 45Overview of the day The power of Drosophila as a model organismCourtyard Room A B15 45 16 45Ice breaking activity Flash talksCourtyard Room A B16 45 17 05Coffee breakCourtyard Room A B17 05 17 50Lecture Drosophila functional evolutionary genomicsAmanda Larracuente University of Rochester USACourtyard Room A B17 50 18 05Q ACourtyard Room A B18 05 19 35Practical session Drosophila anatomy development genetics and outreach advocacyMatthew Benton EMBL Heidelberg GermanyLautaro Gandara EMBL Heidelberg GermanyAndreas Prokop The University of Manchester UKCourtyard Room A B19 35 21 35Dinner and networkingEMBL Canteen21 35Bus to hotelEMBL Bus Stop Day 2 Monday 17 July 2023 Time Europe Berlin SessionLocation08 30 09 00Bus from hotel to EMBL ATC entranceB B Hotel09 00 09 10Overview of the day Discerning function through perturbationCourtyard Room A B09 10 09 30Lab safety instructionsIrena Provaznikova EMBL Heidelberg GermanyCourtyard Room A B09 30 10 15Lecture Screen design in fliesMarc Freeman Vollum Institute USACourtyard Room A B10 15 10 30Q ACourtyard Room A B10 30 11 00Coffee break and meet the speakersCourtyard Room A B11 00 11 45Lecture Fly behavioural screensJulie Simpson University of California Santa Barbara USACourtyard Room A B11 45 12 00Q ACourtyard Room A B12 00 13 00Lunch breakEMBL Canteen13 00 14 45Practical session CRISPR design in fliesTrainers Noa Borts EMBL Heidelberg GermanyKate O Connor Giles Brown University USAScott Graz Brown University USAAudrey Medeiros Brown University USAComputer Training Lab14 45 15 15Coffee break and meet the speakersfor virtual participantsFlex Lab A B15 15 17 00Practical session CRISPR design in flies continued Trainers Noa Borts EMBL Heidelberg GermanyKate O Connor Giles Brown University USAScott Graz Brown University USAAudrey Medeiros Brown University USAComputer Training Lab17 00 19 30Poster session I 10 students Helix A19 30 20 30Vegetarian dinnerEMBL Canteen20 30Bus to hotelEMBL Bus Stop Day 3 Tuesday 18 July 2023 Time Europe Berlin SessionLocation08 30 09 00Bus from hotel to EMBL ATC entranceB B Hotel09 00 09 10Overview of the day Revealing new insights through live imagingCourtyard Room A B09 10 09 55Lecture Imaging across scalesJustin Crocker EMBL Heidelberg GermanyCourtyard Room A B09 55 10 10Q ACourtyard Room A B10 10 10 40Coffee break and meet the speakersCourtyard Room A B10 40 11 25Lecture Quantitative imaging of transcriptionHernan Garcia University of Berkeley USACourtyard Room A B11 25 11 40Q ACourtyard Room A B11 40 12 40Lecture Intro to live imagingJustin Crocker EMBL Heidelberg GermanyHernan Garcia University of Berkeley USACourtyard Room A B12 40 13 40Lunch BreakEMBL Canteen13 40 14 10Embryo mounting for imagingTraining Lab A B14 10 15 40Practical session Imaging in the flyTrainers Matthew Benton EMBL Heidelberg GermanyNoa Borst EMBL Heidelberg GermanyJustin Crocker EMBL Heidelberg GermanyHernan Garcia University of Berkeley USAMindy Perkins EMBL Heidelberg GermanyTraining Lab A B15 40 16 10Coffee break and meet the speakersfor virtual participantsTraining Lab A B16 10 17 40Practical session Imaging in the fly continued Trainers Matthew Benton EMBL Heidelberg GermanyNoa Borst EMBL Heidelberg GermanyJustin Crocker EMBL Heidelberg GermanyHernan Garcia University of Berkeley USAMindy Perkins EMBL Heidelberg GermanyTraining Lab A B17 40 20 10Poster session II 10 students Helix A20 10 21 10Pizza dinnerATC Rooftop Lounge21 10 22 10Career chatATC Rooftop Lounge22 10Bus to HotelEMBL Bus Stop Day 4 Wednesday 19 July 2023 Time Europe Berlin SessionLocation08 15 09 00Bus from hotel to EMBL ATC entranceB B Hotel09 00 09 10Overview of the dayNew views from single cell genomicsCourtyard Room A B09 10 09 55Lecture Systems biology of neural tissue differentiationRobert Zinzen Max Delbr ck Center for Molecular Medicine GermanyCourtyard Room A B09 55 10 10Q ACourtyard Room A B10 10 10 40Coffee break and meet the speakersCourtyard Room A B10 40 11 25Lecture Three dimensional organization of the genomeYad Ghavi Helm Institute Genomics Functional De Lyon FranceCourtyard Room A B11 25 11 40Q ACourtyard Room A B11 40 12 25Lecture Genome regulation during developmental transitionsEileen Furlong EMBL Heidelberg GermanyCourtyard Room A B12 25 12 40Q ACourtyard Room A B12 40 13 30Lunch BreakEMBL Canteen13 30 13 40Group photoATC Entrance13 40 15 10Practical session Genomics at single cell resolutionTrainers Baptiste Alberti Institute Genomics Functional De Lyon FranceYad Ghavi Helm Institute Genomics Functional De Lyon FranceRobert Zinzen Max Delbr ck Center for Molecular Medicine GermanyTraining Lab A B15 10 15 40Coffee break and meet the speakersfor virtual participantsComputer Training Lab15 40 17 10Practical session Genomics at single cell resolution continued Trainers Baptiste Alberti Institute Genomics Functional De Lyon FranceYad Ghavi Helm Institute Genomics Functional De Lyon FranceHarald V hringer EMBL Heidelberg GermanyRobert Zinzen Max Delbr ck Center for Molecular Medicine GermanyComputer Training Lab17 10 19 10Poster session III 6 virtual students Courtyard Room A B19 10 20 10DinnerEMBL Canteen20 10Bus to hotelEMBL Bus Stop Day 5 Thursday 20 July 2023 Time Europe Berlin SessionLocation08 15 09 00Bus from hotel to EMBL ATC entranceB B Hotel09 00 09 10Overview of the dayDrosophila diversity and evolutionCourtyard Room A B09 10 09 40Lecture The genetic basis of complex traitsLuisa Pallares The Friedrich Miescher Laboratory GermanyCourtyard Room A B09 40 09 55Q ACourtyard Room A B09 55 10 25Coffee break and meet the speakersCourtyard Room A B10 25 10 55Lecture Genetics of phenotype evolutionNicolas Gompel Ludwig Maximilians Universit t M nchen GermanyCourtyard Room A B10 55 11 10Q ACourtyard Room A B11 10 11 55Lecture The evolution of a complex morphology at a single cell resolutionElla Preger Ben Noon Technion Israel Institute of Technology IsraelCourtyard Room A B11 55 12 10Q ACourtyard Room A B12 10 13 10Lunch BreakEMBL Canteen13 10 15 10Practical session Drosophila behavioral analysisTrainers Saudat Alishayeva The Friedrich Miescher Laboratory GermanyNicolas Gompel Ludwig Maximilians Universit t M nchen GermanyLuisa Pallares The Friedrich Miescher Laboratory GermanyJames Tan Sheng Yi The Friedrich Miescher Laboratory GermanyNatascha Turetzek Ludwig Maximilians Universit t M nchen GermanyTraining Lab A B15 10 15 40Coffee break and meet the speakersfor virtual participantsCourtyard Room A B15 40 17 40Practical session Drosophila behavioral analysis continued Trainers Saudat Alishayeva The Friedrich Miescher Laboratory GermanyNicolas Gompel Ludwig Maximilians Universit t M nchen GermanyLuisa Pallares The Friedrich Miescher Laboratory GermanyJames Tan Sheng Yi The Friedrich Miescher Laboratory GermanyNatascha Turetzek Ludwig Maximilians Universit t M nchen GermanyTraining Lab A B17 40 18 25Bus to city centre with 10 min stop at hotel EMBL Bus Stop18 25 19 30Free afternoon City Centre19 30 21 30Downtown dinnerUrban Kitchen Day 6 Friday 21 July 2023 Time Europe Berlin SessionLocation08 15 09 00Bus from hotel to EMBL ATC entranceB B Hotel09 00 09 10Overview of the dayOrganismal interactionsCourtyard Room A B09 10 09 55Lecture The interaction of Drosophilamelanogaster with microorganismsLu s Teixeira Cat lica Biomedical Research Centre and Instituto Gulbenkian de Ci ncia PortugalCourtyard Room A B09 55 10 10Q ACourtyard Room A B10 10 10 40Coffee break and meet the speakersCourtyard Room A B10 40 12 10Practical session Analysis of fly infectionTrainer Matthew Benton EMBL Heidelberg GermanyLautaro Gandara EMBL Heidelberg GermanyMigla Miskinyte Instituto Gulbenkian de Ci ncia PortugalLu s Teixeira Cat lica Biomedical Research Centre and Instituto Gulbenkian de Ci ncia PortugalTraining Lab A B12 10 13 10Lunch BreakEMBL Canteen13 10 14 10Wrap up of practicals and final data analysisCourtyard Room A B14 10 15 10Feedback round and departureCourtyard Room A B Virtual programme Got something to say Tweet it EMBODrosophila All lectures panels and discussions will be live streamed facilitating enhanced informal discussions Pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Virtual participants will have access to the practical sessions in the form of virtual learning activities in the EMBL eCampus platform and live Q A with the trainers Some practical sessions may be delivered in a fully hybrid mode Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change The course will be live streamed in CET time zone and lectures will not be recorded Day 1 Sunday 16 July 2023 Time Europe Berlin Session15 30 15 40Welcome introduction and housenotesJustin Crocker EMBL Heidelberg GermanyKate O Connor Giles Brown University USAElla Preger Ben Noon Technion Israel Institute of Technology IsraelAndreas Prokop The University of Manchester UK15 40 15 45Overview of the day The power of Drosophila as a model organism15 45 16 45Ice breaking activity Flash talks16 45 17 05Break17 05 17 50Lecture Drosophila functional evolutionary genomicsAmanda Larracuente University of Rochester USA17 50 18 05Q A18 05 19 35Practical session Drosophila anatomy development genetics and outreach advocacyMatthew Benton EMBL Heidelberg GermanyLautaro Gandara EMBL Heidelberg GermanyAndreas Prokop The University of Manchester UK Day 2 Monday 17 July 2023 Time Europe Berlin Session09 00 09 10Overview of the day Discerning function through perturbation09 10 09 30Lab safety instructionsIrena Provaznikova EMBL Heidelberg Germany09 30 10 15Lecture Screen design in fliesMarc Freeman Vollum Institute USA10 15 10 30Q A10 30 11 00Break11 00 11 45Lecture Fly behavioural screensJulie Simpson University of California Santa Barbara USA11 45 12 00Q A12 00 13 00Break13 00 14 45Practical session CRISPR design in fliesTrainers Noa Borts EMBL Heidelberg GermanyKate O Connor Giles Brown University USAScott Graz Brown University USAAudrey Medeiros Brown University USA14 45 15 15Meet the speakers for virtual participants15 15 17 00Practical session CRISPR design in flies continued Trainers Noa Borts EMBL Heidelberg GermanyKate O Connor Giles Brown University USAScott Graz Brown University USAAudrey Medeiros Brown University USA Day 3 Tuesday 18 July 2023 Time Europe Berlin Session09 00 09 10Overview of the dayRevealing new insights through live imaging09 10 09 55Lecture Imaging across scalesJustin Crocker EMBL Heidelberg Germany09 55 10 10Q A10 10 10 40Break10 40 11 25Lecture Quantitative imaging of transcriptionHernan Garcia University of Berkeley USA11 25 11 40Q A11 40 12 40Lecture Intro to live imaging Justin Crocker EMBL Heidelberg GermanyHernan Garcia University of Berkeley USA12 40 13 40Break13 40 14 10Embryo mounting for imaging14 10 15 40Practical session Imaging in the flyTrainers Matthew Benton EMBL Heidelberg GermanyNoa Borst EMBL Heidelberg GermanyJustin Crocker EMBL Heidelberg GermanyHernan Garcia University of Berkeley USAMindy Perkins EMBL Heidelberg Germany15 40 16 10Meet the speakers for virtual participants16 10 17 40Practical session Imaging in the fly continued Trainers Matthew Benton EMBL Heidelberg GermanyNoa Borst EMBL Heidelberg GermanyJustin Crocker EMBL Heidelberg GermanyHernan Garcia University of Berkeley USAMindy Perkins EMBL Heidelberg Germany Day 4 Wednesday 19 July 2023 Time Europe Berlin Session09 00 09 10Overview of the day New views from single cell genomics09 10 09 55Lecture Systems Biology of Neural Tissue DifferentiationRobert Zinzen Max Delbr ck Center for Molecular Medicine Germany09 55 10 10Q A10 10 10 40Break10 40 11 25Lecture Three dimensional organization of the genomeYad Ghavi Helm Institute Genomics Functional De Lyon France11 25 11 40Q A11 40 12 25Lecture Genome regulation during developmental transitionsEileen Furlong EMBL Heidelberg Germany12 25 12 40Q A12 40 15 10Break15 10 15 40Meet the speakers for virtual participants15 40 17 10Practical session Genomics at single cell resolutionTrainers Baptiste Alberti Institute Genomics Functional De Lyon FranceYad Ghavi Helm Institute Genomics Functional De Lyon FranceHarald V hringer EMBL Heidelberg GermanyRobert Zinzen Max Delbr ck Center for Molecular Medicine Germany17 10 19 10Poster session III 6 virtual students Day 5 Thursday July 2023 Time Europe Berlin Session09 00 09 10Overview of the dayDrosophila diversity and evolution09 10 09 40Lecture The genetic basis of complex traitsLuisa Pallares The Friedrich Miescher Laboratory Germany09 40 09 55Q A09 55 10 25Break10 25 10 55Lecture Genetics of phenotype evolutionNicolas Gompel Ludwig Maximilians Universit t M nchen Germany10 55 11 10Q A11 10 11 55Lecture The evolution of a complex morphology at a single cell resolutionElla Preger Ben Noon Technion Israel Institute of Technology Israel11 55 12 10Q A12 10 13 10Break13 10 15 10Practical session Q A Genomics at single cell resolution15 10 15 40Meet the speakers for virtual participants Day 6 Friday 21 July 2023 Time Europe Berlin Session09 00 09 10Overview of the day Organismal interactions09 10 09 55Lecture The interaction of Drosophila melanogaster with microorganismsLu s Teixeira Cat lica Biomedical Research Centre and Instituto Gulbenkian de Ci ncia Portugal09 55 10 10Q A10 10 10 40Break10 40 12 10Practical session Q A Drosophila behavioral analysis12 10 13 10Break13 10 14 10Wrap up of practicals and final data analysis14 10 15 10Feedback round Practical information Registration fees and motivation letter The course is limited to 20 onsite and 5 virtual participants For selection purposes please note that your application will not be considered without a letter of motivation Registration On site registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Virtual registration fees include access to live streamed course content lectures Q A sessions with speakers and trainers discussion rounds as well as virtual learning activities in the learning platform On site Academia 500On site PhD Student 500On site Industry 1000Virtual Academia 190Virtual PhD Student 190Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the B B Hotel for the default dates of 16 to 21 July 5 nights Please note that the onsite course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the B B Hotel In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 31 50 per night This should be paid by you directly to the Hotel during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the B B Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the B B Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Technical Requirements Virtual participants Below you will find the software and technical requirements for this course You will need admin rights to be able to install the software on your computer and we recommend you try this before the course If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed Internet requirements Client computer with fast and stable internet access for the live virtual sessions Minimum 50 mbit download and 10 mbit upload suitable for pre recorded lectures Preferred 100 mbit download and upload at your host institute While using the software during the course please make sure you have nothing else using your bandwidth We recommend using a wired connection Other Information A classroom application like Zoom will be used for the live talks and Q A sessions More information will be provided closer to the start of the course Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partner Event sponsor Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 PPT Slide 16 9...

Justin Crocker, Kate O'Connor-Giles, Ella Preger-Ben Noon, Andreas Prokop

11 July - 13 July 2023

Open Virtual Ensembl Browser Workshop

Description Work with the Ensembl Outreach team to get to grips with the Ensembl browser accessing gene variation comparative genomics and regulation data and mine these data with BioMart...

Louisse Paola Mirabueno

11 July - 14 July 2023

Predicting evolution

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Advances in genome sequencing and gene editing tools are providing unprecedented insights into biological mechanisms and evolutionary processes In parallel computational and theoretical approaches are providing new insights into our understanding of these new data A goal for this conference is to unite people across theoretical and experimental backgrounds into a coherent focus on predicting evolution The conference will explore the evolution of biological systems at different levels from genes and molecules to organism development and ecology As such we have invited leaders in their respective fields across various scales of evolution molecular network microbial developmental and community Particular emphasis for this conference will be placed on understanding evolution through mechanistic biology We will explore recent advances in experimental and theoretical approaches to study how genetic and non genetic changes drive and constrain evolution The meeting will offer a training ground and productive learning experience for attendees and provide networking opportunities for scientists across disciplines relevant to evolutionary biology It should be of particular interest to those working at the interface of evolution quantitative genetics development and systems biology Session topics Predicting the evolution of molecules part 1 Predicting regulatory network evolution Predicting cellular evolution Prediction developmental evolution Predicting population and community evolution Predicting the evolution of molecules part 2 Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Naama Barkai Weizmann Institute of Science Israel Camille Berthelot Institut Pasteur France Virginie Courtier Orgogozo Institut Jacques Monod Paris France Justin Crocker EMBL Heidelberg Germany Carl de Boer University of British Columbia Vancouver Canada Gautam Dey EMBL Heidelberg Germany Maitreya Dunham University of Washington Seattle USA Georg Hochberg Max Planck Institute for Terrestrial Microbiology Germany Hopi E Hoekstra Harvard University HHMI Cambridge USA Amanda Larracuente University of Rochester USA Michael L ssig University of Cologne Germany Mia Levine University of Pennsylvania USA Peter Lind Ume University Sweden Zachary Lippman CSHL HHMI New York USA Duncan Odom German Cancer Research Center Germany Brandon Ogbunu Yale University New Haven USA Joshua Payne ETH Zurich Switzerland Catherine Peichel University of Bern Switzerland Tzachi Pilpel Weizmann Institute of Science Israel Patricia Wittkopp University of Michigan USA Pedro Beltrao ETH Zurich Switzerland Christian Landry Institute of Integrative and Systems Biology Canada Scientific organisers Justin Crocker EMBL Heidelberg Germany Gautam Dey EMBL Heidelberg Germany Joshua Payne ETH Zurich Switzerland Patricia Wittkopp University of Michigan USA Conference organiser Inna B sselmann EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOPredictEvo Programme is preliminary and subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event All times in the programme below are shown as the time in Europe Berlin Day 1 Tuesday 11 July 2023 Time Europe Berlin Speaker11 30 13 00Registration and light refreshments13 00 13 15Opening remarksSession 1 Predicting the evolution of molecules part 1Chairs Patricia Wittkopp Frank Albert13 15 13 40Meiotic drive and satellite DNA in DrosophilaAmanda Larracuente University of Rochester USA 13 40 14 05Epistasis between promoter activity and coding mutations shapes gene evolvabilityChristian Landry Institute of Integrative and Systems Biology CanadaNot available on demand14 05 14 30Towards a mechanistic basis of evolvabilityTzachi Pilpel Weizmann Institute of Science Israel14 30 14 45Evolutionary playgrounds and how to find them Alexandra Dallaire Royal Botanic Gardens Kew UK14 45 15 00Mutational hotspots of T G in bacteria can be constructed by manipulating local nucleotide context James Horton University of Bath UK15 00 15 30Coffee Break and meet the speakers15 30 15 55Clustering structures at the scale of the known protein universe to study protein evolutionPedro Beltrao ETH Zurich Switzerland15 55 16 10Epistasis facilitates functional evolution in an ancient transcription factor Brian Metzger Purdue University USA16 10 16 25B subtilis underground metabolic richness hinders evolutionary predictability Lianet Noda Garc a The Hebrew University of Jerusalem Israel16 25 16 50The evolution of transcription factor binding specificity a role for disordered regionsNaama Barkai Weizmann Institute of Science Israel16 50 17 15 Antagonistic coevolution preserves genome integrityMia Levine University of Pennsylvania USANot available on demand17 15 17 30Flash talks 117 30 19 00Dinner in canteen19 00 21 00Pub quiz after dinner drinks in canteen Day 2 Wednesday 12 July 2023 Time Europe Berlin SpeakerSession 2 Predicting regulatory network evolutionChairs Joshua Payne Tamar Friedlander09 15 09 40 Evolutionary changes in gene regulatory networks inferred from patterns of co expressionPatricia Wittkopp University of Michigan USA09 40 09 55Predictive genotype phenotype fitness mapping of tetracycline resistance Mato Lagator University of Manchester UK09 55 10 10The contribution of alternative splicing to adaptation in threespine stickleback Carlos Ramirez University of Bern Switzerland10 10 10 35Predicting the evolution of Sars CoV 2Michael L ssig University of Cologne Germany10 35 11 05Coffee break and meet the speakers11 05 11 30Predicting cis regulatory evolution using a deep learning oracleCarl de Boer University of British Columbia Canada11 30 11 45Towards interpretable genomic predictions effect propagation in gene regulatory networks Natalia Ruzickova Institute of Science and Technology Austria11 45 12 00Origin and evolution of dynamic properties of gene regulatory circuits in fluctuating environments Mariana G mez Schiavon Universidad Nacional Aut noma de M xico Mexico12 00 12 25Does lab yeast evolution predict wild yeast evolution Maitreya Dunham University of Washington Seattle USA12 25 14 00LunchSession 3 Predicting cellular evolution Chairs Gautam Dey Tim Fuqua14 00 14 25A foray into convergent mechanisms of embryo implantationCamille Berthelot Institut Pasteur France14 25 14 40Genetic variation in the ubiquitin proteasome system Frank Albert University of Minnesota USA14 40 14 55The Evolution of Biomolecular Condensates Why is it an exciting and fundamental problem Pouria Dasmeh University of Marburg Germany14 55 15 10Simple rules govern metabolome evolution in animals Balazs Papp Biological Research Centre Szeged Hungary 15 10 15 40Coffee break and meet the speakers15 40 15 55Acquired antimicrobial resistance affects the evolvability of resistance to further antibiotic exposure Maria Rosa Domingo Sananes Nottingham Trent University UK15 55 16 10Bacterial evolved resistance against host targeting drugs culminates in predictable antibiotic cross resistance Amir Mitchell University of Massachusetts Medical School USANot available on demand16 10 16 35Predicting experimental evolution in PseudomonasPeter Lind Ume University SwedenNot available on demand16 35 17 00A tail of tales convergent phenotypes driven by divergent genotypesHopi E Hoekstra Harvard University HHMI Cambridge USA remote talk 17 00 17 15Flash talks 217 15 19 00Poster session 1 odd numbers 19 00Free evening Day 3 Thursday 13 July 2023 Time Europe Berlin SpeakerSession 4 Prediction developmental evolutionPatricia Wittkopp Virginie Courtier Orgogozo09 15 09 40 Multidimensional Approach to Decoding the Mysteries of Animal DevelopmentJustin Crocker EMBL Heidelberg Germany09 40 09 55Studying enhancer evolution in Drosophila trichome development using neural networks Tatiana Gaitan Stowers Institute for Medical Research USA 09 55 10 10Polyploidization can we predict its evolutionary pathway David Peris CSIC University of Oslo Spain10 10 10 35Genetic and nongenetic evolutionary determinants of cancer driver choiceDuncan Odom German Cancer Research Center Germany10 35 11 05Coffee break and meet the speakers11 05 11 30Replaying the tape of life how predictable is evolutionCatherine Peichel University of Bern Switzerland11 30 11 45Exploring the mechanisms of adaptation to altered glucose homeostasis in blind Mexican cavefish Ansa Cobham Stowers Institute for Medical Research USA11 45 12 00Evolution of the capability for regulation of gene expression in the symbionts of reed beetles Ana Carvalho Max Planck Institute for Chemical Ecology Germany12 00 12 25Diversification of duplicated genes and their cis regulatory control in shaping natural and engineered plant phenotypesZachary Lippman CSHL HHMI New York USANot available on demand12 25 14 00LunchSession 5 Prediction population and community evolutionJustin Crocker Joe Thornton14 00 14 25The predictability of protein evolution under rewired genetic codesJoshua Payne ETH Zurich SwitzerlandNot available on demand14 25 14 40Strong environmental memory revealed by experimental evolution in static and fluctuating environmentsClare Abreu Stanford University USA14 40 14 55Evolutionary adaptations in microbial microcosms are largely independent of the presence of coevolving species Jonathan Friedman Hebrew University of Jerusalem Israel14 55 15 10Developmental selection and its impact on evolutionary trajectories Paco Majic ETH Zurich Switzerland15 10 15 40Coffee break and meet the speakers15 40 15 55Evolving insertion sequences into promotersTimothy Fuqua University of Zurich Switzerland15 55 16 10The role of promiscuous molecular recognition in the evolution of RNase based self incompatibility Tamar Friedlander Hebrew University of Jerusalem IsraelNot available on demand16 10 16 25The rise Patterns of recombination in snakes reveal a tug of war between PRDM9 and promoter like featuresCarla Hoge Columbia University New York USA16 25 16 40Broad Explorations of SARS CoV 2 Omicron Lineage Protein LandscapesThomas Dupic Harvard University USA16 40 16 55Flash talks 316 55 19 00Poster session 2 even numbers 19 00 21 00Conference dinner in the canteen21 00 23 00Conference party Day 4 Friday 14 July 2023 Time Europe Berlin SpeakerSession 6 Predicting the evolution of molecules part 2Chairs Joshua Payne and Balazs Papp 09 15 09 40The evolutionary road to complexity of earth s most important CO2 fixing enzymeGeorg Hochberg MPI Marburg Germany09 40 09 55A rugged yet easily navigable fitness landscape of antibiotic resistance Andrei Papkou University of Zurich Switzerland09 55 10 10The global simplicity of protein sequence function relationships Joe Thornton University of Chicago USA10 10 10 35Provisional parcels for predicting evolutionBrandon Ogbunu Yale University New Haven USA remote talk 10 35 11 05Coffee break and meet the speakers11 05 11 30Predicting the mutations underlying phenotypic evolution using GephebaseVirginie Courtier Orgogozo Institut Jacques Monod Paris France11 30 11 45How does temperature adaptation influence the evolvability of proteins David Schnettler ETH Zurich Switzerland11 45 12 00Genomic analysis predicts the emergence of de novo Oxalate Metabolism in E coli during Lab Evolution Avihu Yona The Hebrew University Jerusalem Israel12 00 12 15Closing remarks and poster prizeJustin Crocker12 15 13 00Packed lunch and departure13 00Optional Bus to Frankfurt airport Terminal 1 Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for a reduced press rate or in some cases for complimentary registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Inna B sselmann for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 13 June 2023 in some cases at special rates Please email the hotel directly quoting the booking code PEV23 01 to confirm the exact price of the room Hotel AnlageHotel Holl nder Hof Hotel MonptiHotel Bayrischer Hof Hotel ibis HeidelbergPremier Inn Heidelberg CityB B HotelISG Hotel Staycity Aparthotel HeidelbergExzellenz Hotel Leonardo Hotel Heidelberg City CentreSteffi s Hostel Heidelberg Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings You can find the final bus schedule here The bus stops for this conference are Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event You can find the final bus schedule here Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual Participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Media partners International Union of Biochemistry and Molecular Biology Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Justin Crocker, Gautam Dey, Joshua Payne, Patricia Wittkopp

10 July - 14 July 2023

Fluorescence imaging beyond intensity

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This course is organised in cooperation with Leica Microsystems Course overview As fluorescence lifetime based readouts become more accessible this course aims to provide a broad understanding of how the lifetime based information can be leveraged to solve biological questions This application centred course will provide insights into how this additional dimension of fluorescence information can help unveil functional and mechanistic information Audience This course is aimed at PhD students and Post Docs with experience in fluorescence microscopy It will enable them to better apply confocal fluorescence microscopy and in particular lifetime based readouts to their cutting edge research disseminate their gained expertise to colleagues at their home institution and eventually to develop imaging methods beyond the state of the art Modules resources Measuring protein protein interactions Environmental sensing with FRET based and non FRET based biosensors Using fluorescence lifetime for multiplexing Increasing the resolution with tauSTED Endogenous fluorescence harnessing additional information and removing unwanted fluorescence like autofluorescence and background fluorescence Sessions at the microscopes to practice using lifetime imaging in exemplary workflows Analysis of the lifetime based information and applicative conclusions Learning outcomes Understand the basics of fluorescence lifetime Identify which types of research questions and approaches can benefit from lifetime related measurements and how to design such experiments Learn to use common biosensors probes and fluorophores and understand the additional information and contrast provided by fluorescence lifetime Understand the basis of endogenous fluorescence in particular in tissue and animal models and how fluorescence lifetime can help to exploit or cope with their signals Acquire and analyze lifetime related information in different experimental setups Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Luiz Alvarez Leica Microsystems CMS GmbH Germany Marie Erard Universit Paris Saclay France Dorus Gadella Swammerdam Institute for Life Sciences The Netherlands Mariano Gonzalez Pisfil Biomedical Center Munich LMU Munich Germany Manuel Gunkel EMBL Heidelberg Germany Elizabeth Hinde University of Melbourne Australia Kees Jalink The Netherlands Cancer Institute The Netherlands Zhongxiang Jiang Leica Microsystems CMS GmbH Germany Kai Johnsson Max Planck Institute for Medical Research Germany Birgit Koch Max Planck Institute for Medical Research Germany Marko Lampe EMBL Heidelberg Germany Giulia Ossato Leica Microsystems CMS GmbH Germany Sergi Padilla Parra King s College London UK Julia Roberti Leica Microsystems CMS GmbH Germany Ulf Schwarz Leica Microsystems CMS GmbH Germany Irmtraud Steinmetz Leica Microsystems CMS GmbH Germany Timo Zimmermann EMBL Heidelberg Germany Scientific organisers Luis Alvarez Leica Microsystems CMS GmbH Germany Manuel Gunkel EMBL Heidelberg Germany Birgit Koch Max Planck Institute for Medical Research Germany Andrea M lter Leica Microsystems CMS GmbH Germany Course organisers Chris Stocks Course and Conference Team Lead EMBL Heidelberg Germany Swetlana Krez Training Lab Manager EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLFluorescenceLifetime Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change All participants will attend all practicals in turns Day 1 Monday 10 July 2023 Time SpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 09 15 Welcome registrationEMBL Imaging Centre09 15 09 45Icebreaking activityEMBL Imaging Centre09 45 10 45 Lecture Introduction to fluorescence lifetime based readoutsKees Jalink Dorus Gadella EMBL Imaging Centre10 45 11 00Coffee BreakEMBL Imaging Centre11 00 12 00Lecture Visualization and analysis of lifetime based informationGiulia Ossato Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre12 00 13 00LunchEMBL Canteen13 00 14 00Lecture The application of FRET FLIM to study protein protein interactions and spatial organization of proteins in the cells Marie Erard Universit Paris Saclay FranceEMBL Imaging Centre14 00 16 00Practical sessions 1 2EMBL Imaging Centre16 00 16 15Coffee breakEMBL Imaging Centre16 15 17 45Practical sessions 1 2EMBL Imaging Centre17 45 18 00Wrap up sessionEMBL Imaging Centre18 00 19 00DinnerEMBL canteen19 45 Bus from EMBL to ISG HotelEMBL bus stop Day 2 Tuesday 11 July 2023 TimeSpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 11 00 Participants flash talksEMBL Imaging Centre11 00 11 15Coffee breakEMBL Imaging Centre11 15 12 15 Lecture Time Domain Fluorescence lifetime Imaging of cAMP Levels with EPAC Based FRET SensorsKees Jalink The Netherlands Cancer Institute The NetherlandsEMBL Imaging Centre12 15 13 15 LunchEMBL Canteen13 15 14 00 Lecture Fluorescence lifetime based biosensorsDorus Gadella Swammerdam Institute for Life Sciences The NetherlandsEMBL Imaging Centre14 00 16 00Practical sessions 1 2EMBL Imaging Centre16 00 16 15Coffee breakEMBL Imaging Centre16 15 17 45Practical sessions 1 2EMBL Imaging Centre17 45 18 00Wrap up sessionEMBL Imaging Centre18 00 19 30Tips Tricks with concurrent Pizza dinnerEMBL Imaging Centre19 45Bus from EMBL to ISG HotelEMBL bus stop Day 3 Wednesday 12 July 2023 TimeSpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 10 00 Lecture Introduction to STED microscopy and tauSTEDUlf Schwarz Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre10 00 11 00 Lecture STED microscopy with a single depletion laser using five fluorochromes and fluorescence lifetime phasor separationMariano Gonzalez Pisfil Biomedical Center Munich GermanyEMBL Imaging Centre11 00 11 15 Coffee breakEMBL Imaging Centre11 15 12 00 Lecture Label free imaging and endogenous fluorescence Giulia Ossato Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre12 00 12 15Group photoEMBL Imaging Centre12 15 13 15LunchEMBL canteen13 15 15 45 Practical sessions 3 6EMBL Imaging Centre15 45 16 15Coffee breakEMBL Imaging Centre16 15 18 45Practical sessions 3 6EMBL Imaging Centre18 45 19 00Wrap up sessionEMBL Imaging Centre19 00 20 30Dinner discussionsEMBL canteen20 35Bus from EMBL to ISG HotelEMBL bus stop Day 4 Thursday 13 July 2023 TimeSpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 10 00 Lecture TauSense Tools making lifetime based readouts easily accessibleJulia Roberti Leica Microsystems CMS GmbH GermanyEMBL Imaging Centre10 00 11 00Lecture Synthetic fluorescent probes for live cell imagingKai Jonsson Max Planck Institute for Medical Research GermanyEMBL Imaging Centre11 00 11 15Coffee breakEMBL Imaging Centre11 15 12 15Lecture FP based Multicolour experiments with FLIMSergi Padilla Parra King s College UKEMBL Imaging Centre12 15 13 15LunchEMBL Imaging Centre13 15 15 45Practical sessions 3 6EMBL Imaging Centre15 45 16 15Coffee breakEMBL Imaging Centre16 15 18 45Practical sessions 3 6EMBL Imaging Centre18 45 19 15Wrap up sessionEMBL Imaging Centre19 45Bus to Heidelberg downtownEMBL bus stop20 00 22 00Course dinner downtown Day 5 Friday 14 July 2023 TimeSpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 10 00 Lecture The phasor approach to fluorescence lifetime analysis of biosensor F rster resonance energy transfer FRET Elisabeth Hinde University of Melbourne AustraliaEMBL Imaging Centre10 00 11 00Lecture Open discussionEMBL Imaging Centre11 00 11 15Coffee breakEMBL Imaging Centre11 15 12 15Practical session Lifetime based readout analysis and interpretationEMBL Imaging Centre12 15 13 15Lunch EMBL Imaging Centre13 15 15 15Practical session Lifetime based readout analysis and interpretationEMBL Imaging Centre15 15 15 30Coffee breakEMBL Imaging Centre15 30 16 15Round Table The future of lifetime based read outs16 15 16 30Feedback round and Wrap up16 30Bus to Heidelberg train station and city centerEMBL bus stop Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 500PhD Student 500Industry 1000 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 6 nights Sunday 9 July to Saturday 15 July 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code MIC23 03 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Co organisers Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Luis Alvarez, Manuel Gunkel, Birgit Koch, Andrea Mülter

10 July - 14 July 2023

Cancer genomics and transcriptomics

Description This course will focus on the analysis of data from genomic studies of cancer It will also highlight the application of transcriptomic analysis and single cell technologies in cancer Talks and interactive sessions will give an insight into the bioinformatic concepts required to analyse such data whilst practical sessions will enable the participants to apply statistical methods to the analysis of cancer genomics data under the guidance of the trainers In person course We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing...

Sophie Spencer

5 July 2023

A guide to sequence analysis resources in Job Dispatcher

Description The Job Dispatcher team at EMBL EBI provides access to various bioinformatics sequence analysis tools and biological datasets This webinar will introduce different tool categories and explain how to find access and use these tools for your sequence analysis It will cover the latest features and user documentation of the sequence analysis tools and also demonstrate how to access these tools programmatically...

3 July - 7 July 2023

Proteomics bioinformatics

Description This course provides hands on training in the basics of mass spectrometry MS and proteomics bioinformatics Participants will receive training on how to use search engines and post processing software quantitative approaches MS data repositories the use of public databases for protein analysis annotation of subsequent protein lists and incorporation of information from molecular interaction and pathway databases This course is organised in association with the Vlaams Instituut voor Biotechnologie VIB In person course The course fee is inclusive of four nights of accommodation and catering including dinner We plan to deliver this course in person onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website...

Shereen Pethania

3 July - 4 July 2023

Development and morphogenesis: Symposium in honour of Maria Leptin

Description If you are not redirected please visit the event website...

Fiona Watt

28 June 2023

Developing community resources for bioimage analysis training

Description Bioimage analysis is becoming an established field in bioinformatics however consolidated curricula and reusable training material are still hard to come by This webinar will showcase the development of an open website for hosting bioimage analysis training materials where everyone can use and contribute to the material...

27 June - 30 June 2023

New approaches and concepts in microbiology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety recommendations if attending the on site event Symposium overview This symposium will cover a broad range of topics in microbiology featuring diverse research on bacterial physiology bacterial communities and microbiomes bacterial host and phage interactions and bacteria in their natural ecological contexts Emphasis will be placed on novel approaches and technologies from systems based to single cell that drive each field or have the potential to revolutionise future research in microbiology This meeting is the sixth of its kind part of a successful series which started in 2013 and held biannually since becoming a must attend event for scientists working with bacteria and new technologies The focus remains on the interface of new technologies and new biology in bacteria but the thematic areas change and speaker line ups do not overlap between consecutive symposia This symposium aims at bridging the gap between traditional microbiology and novel technologies by exposing microbiologists to new ways of addressing their hypotheses At the same time it provides a platform for systems or technology experts to get a better understanding of the important questions in the field Session topics Bacterial systems biology Cell biology and protein machineries Regulation signalling and transcriptional networks Pathogenesis and anti infectives Phage Microbiomes and microbial interactions Environment and evolution What past participants say about the conference The conference tackled all the important topics in current microbiology with an adequate length and a good variety of presenters The networking sessions were good as they can be online without food and drinks and the discussion panels may have been the highlight for me Julia Sanchez Garrido Imperial College London UK Speakers Speakers Helge Bode Max Planck Institute for Terrestrial Microbiology Germany Zemer Gitai Princeton University USA Carol Gross University of California San Fransisco USA Stephan Kamrad University of Cambridge UK Nicole Koropatkin University of Michigan USA Ruth Ley Max Planck Institute for Developmental Biology Germany Gene Wei Li Massachusetts Institute of Technology USA Daniel Lopez Spanish National Centre for Biotechnology CNB Spain Julia Mahamid EMBL Heidelberg Germany Luciano Marraffini The Rockefeller University USA Karen Maxwell University of Toronto Canada T m Mignot CNRS Aix Marseille University France Sara Mitri Universit de Lausanne Switzerland Charlotte Odendall King s College London UK Kim Orth The University of Texas Southwestern Medical Center USA Alvaro Sanchez Centro Nacional de Biotecnolog a Spain Mohammad Seyedsayamdost Princeton University USA Feng Shao National Institute of Biological Sciences China Rotem Sorek Weizmann Institute of Science Israel Natalia Tschowri Leibniz University Hannover Germany Waldemar Vollmer Newcastle University UK Michael Zimmermann EMBL Heidelberg Germany Scientific Organisers Pascale Cossart Institute Pasteur France Sophie Helaine Harvard Medical School USA KC Huang Stanford Universtity USA Michael Laub Massachusetts Institute of Technology USA Nassos Typas EMBL Heidelberg Germany Conference Organiser Lea Hohmann EMBL Heidelberg Germany Programme Got something to say Tweet it EESMicrobiology Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk and the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 27 June 2023 Time Europe Berlin Speaker12 00 13 30Registration and Light refreshments13 30 13 45Opening remarks13 45 14 45Panel discussion 10 years after future evolution of microbiology meeting s at EMBLModerator Pascale Cossart14 45 15 15Coffee Break15 15 19 00Session 1 Systems biologySession chairs Christian Ahrens and Jason Peters 15 15 15 45Speeding up access and function of microbial natural productsHelge Bode Max Planck Institute for Terrestrial Microbiology GermanyNot available on demand15 45 16 15Unravelling metabolic heterogeneity and cross feeding using metaproteomics and stable isotope labelling Stephan Kamrad University of Cambridge UK16 15 16 30Co seq easy identification of single cell inherited variability unveils the co existence of distinct phenotypes in pathogenic E coliRaya Faigenbaum Romm The Hebrew University of Jerusalem IsraelNot available on demand16 30 17 00Genome wide CRISPRi based functional genomic analyses in model Gram positive bacteria Terrabacteria Carol Gross University of California San Francisco USA17 00 17 30Coffee Break17 30 18 00Systematic strategies to uncover the Achilles heels of AMRNassos Typas EMBL Heidelberg GermanyNot available on demand18 00 18 15Multiomics profiling provides insights into niche adaptation and alternative carbon source preference in Streptococcus pneumoniaeVincent de Bakker University of Lausanne Switzerland18 15 18 45Runaway transcription and its genome wide impactGene Li Massachusetts Institute of Technology USANot available on demand18 45 19 00Genetic interaction landscape of Streptococcus pneumoniaeLok To Chris Sham National University of Singapore Singapore19 00 20 30Dinner in Canteen20 30 23 00Drinks in ATC Roof top lounge Meet the speakers only from 20 30 21 00 andMeet the speakers of the day and editors Lavinia Arseni FEBS Letters Achim Breiling EMBO reports Ieva Gailite EMBO Paula Jauregui PLOS Francois Mayer Nature Ruby Ponnudurai Review Commons Cesar Sanchez Nature Christina Tobin Kahrstrom Nature Day 2 Wednesday 28 June 2023 Time Europe Berlin Speaker09 00 12 30Session 2 Cell biology and protein machineriesSession chairs Despoina Mavridou and Kai Thormann09 00 09 30Universal properties of the intrinsic microbial response to temperature fluctuations KC Huang Stanford University USA09 30 09 45Live tracking of Pseudomonas aeruginosa infections in lung organoids reveals strong metabolic and biophysical fitness trade offsLucas Meirelles EPFL SwitzerlandNot available on demand09 45 10 15Towards a mechanistic understanding of multicellular behaviors in bacteriaT m Mignot CNRS Aix Marseille University France10 15 10 30Physiological adaptation in flagellar architecture improves bacterial chemotaxis in complex environmentsMarianne Grognot RWTH Aachen Germany Rowland Institute at Harvard USA10 30 11 00Coffee Break11 00 11 30Enabling discovery by in cell structural biology Julia Mahamid EMBL Heidelberg Germany11 30 11 45Multi scale imaging of an Asgard archaeon illuminates the origin of the eukaryotic cytoskeletonFlorian Wollweber ETH Z rich SwitzerlandLivestream only11 45 12 15How E coli maintains robust cell envelope growthWaldemar Vollmer Newcastle University UKNot available on demand12 15 12 30Resurrecting ancestral membranes with minimal bacterial cellsJames Saenz TU Dresden Germany12 30 14 00Lunch 13 30 14 00Meet the speakers of the day14 00 15 30Poster Session 1 odd numbers Please see the poster overview here 15 30 19 00Session 3 Regulation signalling and transcriptional networksSession chairs Kirsten Jung and Benjamin Ezraty15 30 16 00Structural and functional characterization of bacterial membrane microdomainsDaniel Lopez Spanish National Centre for Biotechnology CNB Spain16 00 16 15Robust Coherent and Synchronized Circadian Clock Controlled Oscillations along Multicellular Filaments of Anabaena cyanobacteriaRinat Arbel Goren Weizmann Institute of Science IsraelNot available on demand16 15 16 45Bridging c di GMP signalling and biopolymer metabolism in StreptomycesNatalia Tschowri Leibniz University Hannover Germany16 45 17 00How a metabolic thermometer and a transcriptional feedback loop maintain a fluid membrane in Escherichia coliGreg Bokinsky TU Delft The Netherlands17 00 17 30Coffee Break17 30 18 00Mechanisms and Evolutionary Dynamics of Bacterial Anti Phage Defense SystemsMichael Laub Massachusetts Institute of Technology USANot available on demand18 00 18 15Atlas of mRNA translation and decay for bacteriaLilit Nersisyan Karolinska Institutet Sweden18 15 18 45New tools for new antibiotics Machine learning imaging and single cell sequencingZemer Gitai Princeton University USA18 45 19 00High throughput expression analysis reveals evolution of key virulence pathways in MtbPeter Culviner Harvard School of Public Health USANot available on demand19 00 20 30Dinner in Canteen20 30 22 30Drinks in ATC Roof top lounge Day 3 Thursday 29 June 2023 Time Europe Berlin Speaker09 00 12 30Session 4 Phage bacterial interactionsSession chairs Ditlev Brodersen and Francois Rousset09 00 09 30New mechanisms of anti phage defense and counter defenseRotem Sorek Weizmann Institute of Science IsraelNot available on demand09 30 09 45Genomics based predictions of phage bacteria interactions at the species levelAude Bernheim Pasteur Institute France09 45 10 00A multitude of diverse anti retron proteins in phagesJacob Bobonis EMBL Heidelberg Germany10 00 10 30Luciano Marraffini The Rockefeller University USA10 30 11 00Coffee Break11 00 11 15Bacteriophages use noncontiguous operons to avoid autoimmunity from cognate immune systemsJakob Rost l Imperial College London UK11 15 11 30Identification of factors required for protein import into a bacteriophage nucleusClaire Kokontis University of California San Francisco USA11 30 12 00Pseudomonas prophages exploit bacterial signaling to modulate phage receptor activityKaren Maxwell University of Toronto Canada12 00 12 15A discovery pipeline for prophage induction mediated antagonism between natural Vibrio isolatesJulie Chen Broad Institute MIT USA12 15 12 30It s parasites all the way down Discovery and characterization of phage satellites in bacterial genomesJorge Moura de Sousa Institut Pasteur France12 30 15 30Lunch 13 30 14 00Meet the speakers of the day14 00 15 30Poster Session 2 even numbers Please see the poster overview here 15 30 19 00Session 5 Pathogenesis Anti infectivesSession chairs Alexandre Persat and Karin Strijbis15 30 16 00Unlocking antibiotic persisters during infectionSophie Helaine Harvard Medical School USANot available on demand16 00 16 15The antiphage defense system CBASS controls resistance and enables killing by antifolate antibiotics in Vibrio choleraeAna Rita Brochado University of W rzburg GermanyNot available on demand16 15 16 30Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual targeting antibioticAnupama Khare National Cancer Institute USANot available on demand16 30 17 00Vibrio parahaemolyticus is a facultative intracellular pathogen survival proliferation and escape from host cellKim Orth The University of Texas Southwestern Medical Center USA17 00 17 30Coffee Break17 30 18 00Shigella evades pyroptosis by arginine ADP riboxanation of caspase 11 Feng Shao National Institute of Biological Sciences China18 00 18 15Infection induced membrane ruffling initiates danger and immune signalling via the mechanosensor PIEZO1Andrea Puhar The Laboratory for Molecular Infection Medicine Sweden MIMS Ume University Sweden18 15 18 45Interferon tug of war between host and pathogenCharlotte Odendall King s College London UKNot available on demand18 45 19 00Temporal single cell RNA sequencing captures macrophage reprogramming by SalmonellaChristoph Toussaint Helmholtz Centre for Infection Research Germany19 00 21 00Dinner21 00 00 00DJ and party Day 4 Friday 30 June 2023 09 00 12 30Session 6 Microbiomes Microbial InteractionsSession chairs Lisa Maier and Caroline Taouk09 00 09 30Codiversification of humans with gut and oral microbiota and their characteristicsRuth Ley Max Planck Institute for Developmental Biology Germany09 30 09 45Gut bacteria wrestle with SUMO in the intestinal arenaDavid Ribet University of Rouen France09 45 10 15Nicole Koropatkin10 15 10 30FISHing for more visualising the tumour microbiomeShraddha Shitut EMBL Heidelberg GermanyNot available on demand10 30 11 00Coffee Break11 00 11 30Assessing interpersonal differences in gut microbiota metabolism of medical drugs and organic carcinogensMichael Zimmermann EMBL Heidelberg Germany11 30 11 45Mechanisms of gut microbiome remodelling by dietary xenobioticsElizabeth Culp Yale University USA11 45 12 15Natural Product Antibiotics Past Present FutureMohammad Seyedsayamdost Princeton University USA12 15 12 30The marine vitamin marketplace B vitamin auxotrophies shape particle associated microbial communitiesRachel Gregor Massachusetts Institute of Technology USA12 30 14 00Lunch 13 30 14 00Meet the speakers of the day14 00 15 00Poster Session 3 further networking Please see the poster overview here 15 00 17 00Session 7 Environment EvolutionSession chairs Jordi van Gestel and Shaul Pollak15 00 15 30Evolutionary insights to engineering microbial communitiesAlvaro Sanchez Centro Nacional de Biotecnolog a CNB CSIC Spain15 30 15 45Bridging Scales Correlative Measurements of Mass and Metabolism in Single Cell MicroorganismsLars Behrendt Uppsala University Sweden15 45 16 15Using artificial selection to optimise microbial community function Sara Mitri Universit de Lausanne Switzerland16 15 16 30Pre antibiotic era plasmids reveal insights into the historical spread of antimicrobial resistanceAndrian Cazares EMBL EBI UKNot available on demand16 30 16 40Poster Awards and Closing Remarks 16 40 17 00Farewell17 00 NEW TIMES Optional Bus to Frankfurt airport Terminal 1 Tickets may be purchased onsite for 30 EUR 17 00Departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Lea Hohmann for more information Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 30 May 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 06 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergStaycity Aparthotel HeidelbergHotel Bayrischer Hof Leonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergB B HotelHotel MonptiHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Premier Inn Heidelberg City Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop View Conference shuttle bus stops and hotels in a larger map Final bus schedule HERE please note that the buses on the last day will leave now at 17 00 instead of 17 30 17 45 Updated 16 June Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsors Event sponsor Abberior Instruments Biolog Inc Event supporter The FEBS Letters Media partners EMBO reports an EMBO Press journal FEBS Letters a FEBS Press journal PLOS Biology a PLOS journal International Union of Biochemistry and Molecular Biology Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Pascale Cossart, Sophie Helaine, KC Huang, Michael Laub, Nassos Typas

25 June - 30 June 2023

PerMedCoE summer school: from pathway modelling tools to cell-level simulations

Description The course will combine lectures and hands on exercises to Introduce attendees to key practicalities of working with high performance computing HPC clusters Build first hand experience in using PerMedCoE modelling tools CellNOpt CARNIVAL COBREXA MaBoSS PhysiCell and PhysiBoSS Develop a practical appreciation of using workflow managers and containerised PerMedCoE modelling tools to execute biomedical workflows It will also include poster sessions where participants can present their work and plenty of time for interaction between participants and between participants and trainers This course will take place at the Hotel Montany in Seva less than an hour away from Barcelona Visit the PerMedCoE summer school website for more information...

Juanita Riveros

25 June - 30 June 2023

Imaging-based spatial-omics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The aim of the course is to provide participants a comprehensive introduction to the various methods of spatial omics and in particular those of multiplex immunofluorescence and spatial transcriptomics We want to provide a general overview of the methods and assist researchers choose the right method for their needs With hands on practicals the course will teach participants how to carry out open source imaging based methods for cost effective spatial transcriptomics and multiplex immunofluorescence The course will cover all experimental stages including custom reagent preparation sample preparation and data acquisition with various microscopy modalities as well as image processing and data analysis Audience This course is open to PhD students postdocs and staff We seek participants from the following backgrounds tissue biology or biomedicine with experience in basic tissue handling immunofluorescence and basic microscopy Modules Tissue sample preparation In situ sequencing Oligo probe design Oligos and concatemer synthesis by PER In situ sequencing sample imaging Antibody conjugation Immuno SABER imaging Data analysis Speakers Speakers trainers and staff Omer Bayraktar Wellcome Sanger Institute UK Brian Beliveau University of Washington USA virtual Conor Camplisson University of Washington USA Alvaro Crevenna EMBL Rome Italy Yulia Ermakova EMBL Heidelberg Germany Sergio Espinola EMBL Heidelberg Germany Anita Gola The Rockefeller University USA Sebastian Gonzalez Tirado EMBL Heidelberg Germany Tong Li Wellcome Sanger Institute UK Elizabeth Neuman University of California Davis USA virtual Valeriy Pak EMBL Heidelberg Germany Emerald Perlas EMBL Rome Italy Andrea Radtke NIAID NIH USA Robert Reinhardt EMBL Heidelberg Germany Kenny Roberts Wellcome Sanger Institute UK Sinem Saka EMBL Heidelberg Germany Denis Schapiro Heidelberg University Hospital Germany Carolina W hlby SciLifeLab Sweden Scientific organisers Alvaro Crevenna EMBL Rome Italy Emerald Perlas EMBL Rome Italy Sinem Saka EMBL Heidelberg Germany Course organisers Iva Gavran Course and Conference Officer EMBL Heidelberg Germany Programme Got something to say Tweet it Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers will need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 25 June 2023 Time Rome Italy SpeakersLocation12 30 12 45Bus from hotel to Monterotondo train stationAlbergo Leoni12 45 13 00Bus from Monterotondo train station to EMBL RomeMonterotondo train station13 00 13 15Welcome to EMBL RomeBuilding 1413 15 13 45Refreshments light lunch Foyer13 45 14 00Introduction and house notes Alvaro Crevenna EMBL Rome ItalyMain lecture hall14 00 15 00Students flash talksMain lecture hall15 00 15 15Coffee breaktbc15 15 16 00 Introduction to spatial omics Sinem Saka EMBL Heidelberg Germany Main lecture hall16 00 16 15BreakMain lecture hall16 15 17 00Student presentations part 1 Main lecture hall17 00 18 00Practical session Tissue sample preparation Laboratory18 00 19 00Practical session IBEX block stainLaboratory19 00 19 45Bus to hotel and free time20 00 Dinner at local restaurantkindly sponsored by Alpenglow Biosciences Day 2 Monday 26 June 2023 Time Rome Italy SpeakerLocation08 30Bus from hotel to EMBL Rome08 45 09 00Overview of the dayMain lecture hall09 00 10 00Practical session IBEX wash mountLaboratory10 00 10 15 Coffee break Foyer10 15 11 00Multiplex immunofluorescence using iterative bleachingAndrea Radtke NIAID NIH USAMain lecture hall11 00 12 00 Practical session IBEX microscopyLaboratory12 00 13 00 Lunch breakCanteen13 00 14 00 Student presentations part 2 Main lecture hall14 00 15 00Practical session IBEX bleach restainLaboratory15 00 15 15 Coffee break Foyer15 15 16 15Practical session SABER stain overnight antibody Laboratory16 15 18 15Practical session oligo hands onLaboratory18 15 19 00Oligo probe designBrian Beliveau University of Washington USA virtual Main lecture hall19 00 20 00Bus to hotel and free time20 00 Dinner at hotelkindly sponsored by VIZGEN Day 3 Tuesday 27 June 2023 Time Rome Italy SpeakerLocation08 30Bus from hotel to EMBL Rome08 45 09 00Overview of the dayMain lecture hall09 00 10 00Practical session SABER wash and concatemer hybLaboratory10 00 10 15Coffee breakkindly sponsored by Evident EuropeFoyer10 15 11 00Research presentation integrated single cell and spatial transcriptomics Omer Bayraktar Wellcome Sanger Institute UKMain lecture hall11 00 12 00Practical session SABER wash and imager hybLaboratory12 00 13 00Lunch breakCanteen13 00 14 00Practical session Wash mount SABER imaging and restainLaboratory14 00 14 45Student presentations part 3 Main lecture hall14 45 15 15Coffee breakkindly sponsored by Evident EuropeFoyer15 15 17 00Practical session Wash and SABER imagingLaboratory17 00 18 00Multimodal Imaging Approaches for Constructing a Molecular and Cellular Organ Atlas Elizabeth K Neuman Vanderbilt University USA virtual Main lecture hall18 00 19 00Practical session ISS hyb padlockLaboratory19 00 20 00Bus to hotel and free time20 00 Dinner at hotelkindly sponsored by NIKON Europe Day 4 Wednesday 28 June 2023 Time Rome Italy SpeakerLocation08 30Bus from hotel to EMBL Rome08 45 09 00 Overview of the day Main lecture hall09 00 10 00Practical session ISS ligationLaboratory10 00 10 15Coffee break Foyer10 15 10 45Student presentations part 4 Main lecture hall10 45 11 00Antibody conjugation presentationMain lecture hall11 00 12 00Practical session ISS RCALaboratory12 00 13 00Lunch breakCanteen13 00 14 00Practical session PERLaboratory14 00 15 00Decoding and visualizing spatial transcriptomics datasets Carolina Wahlby SciLifeLab SwedenMain lecture hall15 00 15 15Coffee break Foyer15 15 17 00Practical session Antibody conjugationLaboratory17 00 18 00Bus to Rome city centre18 00 20 00Free time20 00Dinnerkindly sponsored by Evident Europe Day 5 Thursday 29 June 2023 Time Rome Italy SpeakerLocation09 30Bus from hotel to EMBL Rome09 45 10 00Overview of the dayMain lecture hall10 00 11 00Practical session ISS L probeLaboratory11 00 11 15Coffee breakkindly sponsored by Canopy BiosciencesFoyer11 15 12 00User case discussionMain lecture hall12 00 13 00Lunch breakCanteen13 00 14 00Practical session ISS imagerLaboratory14 00 15 00Practical session Antibody conjugation continued Laboratory15 00 15 15Coffee breakkindly sponsored by Canopy BiosciencesFoyer15 15 16 30Practical session ISS microscopyLaboratory16 30 18 00Practical session PER continued and PAGE gel imagingLaboratory18 00 18 15BreakMain lecture hall18 15 19 00Student presentations part 5 Main lecture hall19 00 19 45Bus to hotel and free time20 00Dinner at local restaurantkindly sponsored by Canopy Biosciences Day 6 Friday 30 June 2023 Time Rome Italy SpeakerLocation08 30Bus from hotel to EMBL Rome08 45 09 00Overview of the dayMain lecture hall09 00 10 00Image analysis for spatial omics Denis Schapiro University Hospital Heidelberg GermanyMain lecture hall10 00 10 15Coffee breakFoyer10 15 11 00Practical session Visualization ILaboratory11 00 12 00Practical session Visualization IILaboratory12 00 13 00Lunch breakCanteen13 00 15 00Data analysis exercises ISSLaboratory15 00 15 15Coffee breakFoyer15 15 17 00Data analysis exercises ProteinLaboratory17 00 17 45Panel discussionMain lecture hall17 45 18 00Feedback round and closing remarksMain lecture hall18 00 19 45Bus to hotel and free time20 00Dinner at a local restaurant Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses and Workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at a nearby hotel for the default dates of 25 June to 1 July 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfast Local transport Shuttle buses will go from the hotel to EMBL Rome and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address Via Ercole Ramarini 32 00015 Monterotondo RM Italy Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors Event sponsors Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsoring embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Alvaro Crevenna, Emerald Perlas, Sinem Saka

21 June 2023

A guide to identifying suitable patient-derived cancer models in CancerModels.Org

Description Patient derived cancer models PDCMs have become an essential tool in both cancer research and preclinical studies Each model type offers unique advantages and is better suited for specific research areas cell lines are low cost and allow high throughput assays organoids model the impact of intratumour heterogeneity tumour evolution and drug response and patient derived xenografts PDXs retain the tumour architecture to better predict patient response to treatment Seamless access to PDCMs is however hindered by the lack of shared data standards As such PDCMs stakeholders i e researchers clinicians bioinformaticians and analytical tool developers are faced with the challenge to navigate a complex and siloed landscape across multiple commercial and academic resources CancerModels Org is a new cancer research platform that aggregates clinical genomic and functional data from PDXs organoids and cell lines The platform addresses the needs of the stakeholders by standardising harmonising and integrating the complex and diverse data associated with patient derived cancer models Its foundation is underpinned by our efforts to develop and promote the use of descriptive standards e g PDX MI PMID 29092942 to facilitate data interoperability and global sharing of models Further value is provided by enriching the models and data with concepts from well established terminologies e g NCI Thesaurus and links to external resources such as publication platforms raw data archives and cancer specific annotation tools enabling exploration and prioritisation of cancer model variation data CancerModels Org is freely available under an Apache 2 0 license https github com PDCMFinder...

19 June - 21 June 2023

Bioinformatics for principal investigators

Description This course has been designed to provide principal investigators PI s working in the life sciences with an introduction to the challenges of working with biological data as a research leader Starting with a look at where bioinformatics and data science fits into their research teams the course will enable PI s to take a strategic look at the requirements for undertaking such work and how bioinformatics capacity can be developed from personnel through to computational needs It will additionally provide guidance on strategies for managing data the importance of data sharing how to work with computational collaborators and what resources are available across the life sciences to support such work During this course we will not be teaching hands on bioinformatics analysis but we will be signposting appropriate training resources to upskill you and your team In person course We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Additional information This course is currently under construction and so details are subject to change Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic...

Jane Reynolds

19 June - 20 June 2023

Terra incognita: navigating ethical boundaries in the life sciences

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview EMBL is committed to sharing research advances and sustaining scientific interaction through onsite and virtual courses and conferences We are delighted to announce that this conference will be held as a virtual event and invite you to join us online The virtual conference includes talks from invited speakers short talk presenters and networking opportunities Conference overview The 23rd Science and Society Conference will examine the breadth of ethical issues present in the life sciences through the lens of molecular biology research It will explore both the historical context of the intersection between research and ethics and the fast pace of emerging ethical challenges in the life sciences through two case studies technology ethics and organoid research It will present different stakeholder perspectives on navigating ethical boundaries in molecular biology research as well as featuring a live debate on ethics in research issues around dual use and beyond Session topics Technology ethics Ethics and organoids Involving the public in discussions about ethics and science The future of ethics and science how do we go forward What past participants say about the conference The excellent EMBL Science Society conferences are a terrific opportunity for scientists at all career stages and from anywhere in the world to join wide ranging debates on the practical ethical and social implications of today s research Chris Dye University of Oxford UK The conference was awesome I enjoyed the interesting topics covered by experts from reputable institutions from all top universities in the world I felt like I physically attended the conference although it was only virtual Nickson Sananka University of Nairobi Kenya Speakers Keynote Insoo Hyun Harvard Medical School USA Biography Abstract Richard Milne Wellcome Connecting Science UK Biography Sandra Wachter University of Oxford UK Biography Abstract Speakers Nikola Biller Andorno University of Zurich Switzerland Biography Abstract Matthew Cobb The University of Manchester UK Biography Abstract Talya Dayton EMBL Barcelona Spain Biography Abstract Alina Gales Technical University of Munich Germany Biography Abstract Jan Korbel EMBL Heidelberg Germany Biography Abstract Angus Lamond University of Dundee UK Biography Abstract Madeline Lancaster MRC Laboratory of Molecular Biology UK Biography Abstract Fruzsina Moln r G bor BioQuant Zentrum Germany Biography Abstract Barbara Redman New York University USA Biography Abstract Markus Schmidt BioFaction Austria Biography Abstract Mark Sheehan University of Oxford UK Biography Abstract Michelle Garfinkel Independent Policy Researcher USA Biography Abstract Scientific organisers Lucia von Bredow EMBL Heidelberg Germany Conference organiser Diah Yulianti EMBL Heidelberg Germany Giorgia Renne EMBL Heidelberg Germany Programme Got something to say Tweet it SciSoc2023 For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 19 June 2023 Time Europe Berlin Speaker09 45 10 00Opening remarks and housekeeping notesLucia von Bredow EMBL Heidelberg GermanyWelcome remarks Edith Heard EMBL Heidelberg Germany10 00 10 45KEYNOTE LECTURE 1The unfairness of fair machine learningSandra Wachter University of Oxford UK10 45 11 00BreakVirtual Session 1 Technology ethicsSession chair Jan Korbel EMBL Heidelberg Germany11 00 11 15Introduction exploring new and emerging technologies in the life sciencesJan Korbel EMBL Heidelberg Germany11 15 11 45Examining the history of ethics in scientific and technological innovationMatthew Cobb University of Manchester UK11 45 12 00Break12 00 12 30AI in Medicine and the Life Sciences time for a new Hippocratic Oath Nikola Biller Andorno University of Zurich Switzerland12 30 13 15Panel discussionChair Jan Korbel EMBL Heidelberg GermanyPanelists Matthew Cobb University of Manchester UKNikola Biller Andorno University of Zurich SwitzerlandSandra Wachter University of Oxford UK13 15 13 45Break13 45 14 30KEYNOTE LECTURE 2How can ethics help organoid and embryoid research Insoo Hyun Harvard Medical School USAVirtual Session 2 Ethics and organoidsSession chair Talya Dayton EMBL Barcelona Spain14 30 14 45Introduction what are organoids and why are they important in molecular biology research Talya Dayton EMBL Barcelona Spain14 45 15 15Ethical and legal considerations of using organoids in scientific researchFruzsina Moln r G bor BioQuant Zentrum Germany15 15 15 30Break15 30 16 00Opportunities and challenges associated with using organoids in researchMadeline Lancaster MRC Laboratory of Molecular Biology UK16 00 16 45Group DiscussionChair Talya Dayton EMBL Barcelona SpainPanelists Insoo Hyun Harvard Medical School USAFruzsina Moln r G bor BioQuant Zentrum GermanyMadeline Lancaster MRC Laboratory of Molecular Biology UK16 45 17 00Closing remarks day oneLucia von Bredow EMBL Heidelberg Germany Day 2 Tuesday 20 June 2023 Time Europe Berlin Speaker09 45 10 00Welcome back from day one and introduction to Session 3Lucia von Bredow EMBL Heidelberg Germany10 00 10 45KEYNOTE LECTURE 3What role for the public in the ethics of science Richard Milne Kavli Centre for Ethics Science and the Public University of Cambridge UKVirtual Session 3 The Future of Ethics and ScienceSession chair Lucia von Bredow EMBL Heidelberg Germany10 45 11 15Not the Usual Suspects Involving underrepresented groups in research and research ethicsMark Sheehan University of Oxford UK11 15 11 45Panel discussionChair Michele Garfinkel Independent Policy Researcher USAPanelists Richard Milne Kavli Centre for Ethics Science and the Public University of Cambridge UKMark Sheehan University of Oxford UKAlina Gales Technical University of Munich Germany11 45 12 00Break12 00 13 30RoundtableWhat role could should scientists play in discussions and decisions about ethical aspects related to their work Chair Lucia von Bredow EMBL Heidelberg GermanyPanelists Markus Schmidt BioFaction AustriaAngus Lamond University of Dundee UKBarbara Redman New York University UK13 30 13 45Closing remarksLucia von Bredow EMBL Heidelberg Germany Practical information This conference will be virtual and free to all attendees For this reason we invite you to register only if you are certain you will attend the event and to use the cancellation option should you register but realise that you cannot attend in the end Registration system supports additional registrations Note for teachers registering multiple students Please contact us by email to receive a separate link for registering students and yourself By signing up to this platform you hereby confirm that you your students and or their legal guardians consent that their data will be processed by EMBL which is an international organisation as defined in Art 4 Nr 26 GDPR If you have any doubts please contact us by email For further information please refer to the FAQ page Virtual Participation Guidelines Guidelines Please do Use the event specific hashtag as communicated during the event for any related tweets Tweet unless the speaker specifically says otherwise Be mindful of unpublished data Be respectful in tone and content Please don t Capture transmit or redistribute data presented at the meeting unless presenter gives explicit consent Use offensive language in your posts Engage in rudeness or personal attacks Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos You can find these under resources on the conference platform How to ask questions Please use the Q A function It is possible to send a direct message to participants poster presenters and speakers within the conference platform If you have any other questions you can go to the Help Desk on the conference platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on Central European Summer Time CEST unless otherwise stated As many virtual participants are attending from around the world we do our best to accommodate as many timezones as possible when creating the programme Please take your time zone into consideration when planning your attendance Remember to set your time zone in your account Virtual event platforms We are using a virtual event platform for this conference More information about the platform will be shared ahead of the conference Sponsors Media partners FEBS Press International Union of Biochemistry and Molecular Biology Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations...

Lucia von Bredow

18 June - 23 June 2023

Computational modelling of multicellular systems

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview Overview It is a hands on course with 60 of the time devoted to students working on laptops performing exercises designed to give a practical familiarity with different types of computational modelling The course focuses on the dynamics of multicellular systems from embryos to organoids covering both the molecular side how gene regulatory networks perform pattern formation and also the mechanical side in 2D and 3D how the movements and activities of many cells together leads to tissue level morphogenesis and organisation Attendees will also work through the week in small groups on group projects which will be presented on the last day to the whole class Each day will end with a keynote lecture by a prominent researcher in the field putting the topic of the day into context through an example of relevant biological research The week is organised to maximise networking between the students and the teachers and speakers Audience This practical course is aimed at experimental biologists including those with little or no experience in computer modelling to become confident and familiar with these approaches and tools We encourage applicants interested in exploring whether their current projects might benefit from computational modelling Modules resources Pattern formation I gradients interpretation Pattern formation II self organisation 2D vertex models of epithelia Finite Element Modelling of 3D tissues Agent based Modelling of complex tissues Speakers Speakers trainers and staff Katie Bentley The Francis Crick Institute King s College London UK Javier Buceta Institute for Integrative Systems Biology I2SysBio CSIC UV Spain Alex Fletcher Sheffield University UK Jordi Garcia Ojalvo Pompeu Fabra University Spain Tom Hiscock Aberdeen University UK Yanlan Mao University College London UK James Sharpe EMBL Barcelona Spain Alejandro Torres Sanchez EMBL Barcelona Spain Berta Verd Oxford University UK Alexandria Volkening Purdue University USA Scientific organisers Katie Bentley The Francis Crick Institute Kings College London UK James Sharpe EMBL Barcelona Spain Alejandro Torres Sanchez EMBL Barcelona Spain Course organisers Chris Stocks Course and Conference Team Lead EMBL Heidelberg Silvia Autet Balcells Operations Officer EMBL Barcelona Spain Julia Pi Lopez Collaboratorium Project Manager EMBL Barcelona Spain Programme Got something to say Tweet it EMBOMulticellModelling Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 18 June 2023 Time Europe Berlin Speaker Location18 00 19 00Course Overview and Meet and GreetH10 Marina19 30 21 30DinnerH10 Marina Day 2 Monday 19 June 2023 Time Europe Berlin SpeakerLocation08 30 09 00Welcome to Collaboratorium Barcelona CollaboratoriumTopic for Day 2 Agent based modelling Primary trainer Katie BentleyCollaboratorium Edifici Pasqual Maragall 2nd Floor09 00 10 45Lecture 1 Practical 1 Introduction to designing ABMSSeminar Room Aula de Seminari 10 45 11 15Coffee breakBreakout Area11 15 13 00Lecture Practical 2 calibrating validating and analysing ABMs Seminar Room Aula de Seminari 13 00 14 00Lunch breakUPF Canteen14 00 15 45Lecture Practical 3 advanced concepts Seminar Room Aula de Seminari 15 45 16 15Coffee breakBreakout Area16 15 19 00Practical Group Project Session1 ABM project 2 Vertex model project 3 Pattern Formation in tissues 4 Patterning on moving cells 5 FEM project1 Aula Seminari2 Sala de Reunions 13 Sala de Reunions 2 4 Break Out Area 1 right wing 5 Break Out Area 2 left wing 19 00 20 00Keynote lecture 1 Using Agent based Models to explain stripe formation in zebrafishAlexandria Volkening Purdue University USA this talk is remote 20 30 22 00Dinner at Flax Kale Day 3 Tuesday 20 June 2023 Time Europe Berlin SpeakerLocationTopic for Day 3 Vertex Models Primary trainer Alex Fletcher09 00 10 45Lecture Practical 1 Basics Seminar Room Aula de Seminari 10 45 11 15Coffee breakBreakout Area11 15 13 00Lecture Practical 2 Morphogenesis Seminar Room Aula de Seminari 13 00 14 00Lunch breakUPF Canteen14 00 15 45Lecture Practical 3 Combining molecules with mechanics Seminar Room Aula de Seminari 15 45 16 15Coffee breakBreakout Area16 15 19 00Practical Group Project Session1 ABM project 2 Vertex model project 3 Pattern Formation in tissues 4 Patterning on moving cells 5 FEM project1 Aula Seminari2 Sala de Reunions 13 Sala de Reunions 2 4 Break Out Area 1 right wing 5 Break Out Area 2 left wing 19 00 20 00Keynote lecture 2 Vertex modelling to explain epithelial development Javier Buceta Alicante University SpainSeminar Room Aula de Seminari 20 00 22 30Dinner at Caf Menssana Day 4 Wednesday 21 June 2023 Time Europe Berlin SpeakerLocationTopic for Day 4 Pattern FormationPrimary trainer James Sharpe09 00 10 45Lecture Practical 1 Introduction to molecular patterning and the LimbNET toolSeminar Room Aula de Seminari 10 45 11 15Coffee breakBreakout Area11 15 13 00Lecture Practical 2 Morphogen gradients and downstream targetsSeminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 14 45Lecture Practical 3 Regionalisation in a 2D domainSeminar Room Aula de Seminari 14 45 15 45Lecture Practical 4 Periodic patterns from reaction diffusion circuitsSeminar Room Aula de Seminari 15 45 16 15Coffee breakBreakout Area16 15 19 00Networking Flash talks Seminar Room Aula de Seminari 19 00 20 00Keynote lecture 3 Title to be confirmed Tom Hiscock Aberdeen University UK Seminar Room Aula de Seminari 20 00Free evening Day 5 Thursday 22 June 2023 Time Europe Berlin SpeakerLocationTopic for Day 5 GRN Dynamics and cellular movements Primary trainer Berta Verd09 00 10 45Lecture Practical 1 Exploring the relationship between network topology network parameters phase space geometry initial conditions and expression dynamicsSeminar Room Aula de Seminari 10 45 11 15Coffee breakBreakout Area11 15 13 00Lecture Practical 2 Dynamical systems and simulating on moving cellsSeminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 00 15 45Lecture Practical on VEDO A python module for scientific analysis and visualization of 3D objectsSeminar Room Aula de Seminari 14 45 15 45Practical 12 Practical exercises on laptops Seminar Room Aula de Seminari 15 45 16 15Coffee breakBreakout Area16 15 19 00Practical Group Project Session1 ABM project 2 Vertex model project 3 Pattern Formation in tissues 4 Patterning on moving cells 5 FEM project1 Aula Seminari2 Sala de Reunions 13 Sala de Reunions 2 4 Break Out Area 1 right wing 5 Break Out Area 2 left wing 19 00 20 00Informal discussions networking19 00 20 00Keynote lecture 4 Using FEM to model how non uniform proliferation rates lead to controlled buckling and bending of wing disc epithliumYanlan Mao University College London UK This talk is virtual 20 30 22 00Dinner at Ovella Negra Day 6 Friday 23 June 2023 Time Europe Berlin SpeakerLocationTopic for Day 6 Finite element models Primary trainer Alejandro Torres S nchez09 00 10 45Lecture Practical 1 Introduction to elasticity viscosity and plasticity in cell and tissue mechanicsSeminar Room Aula de Seminari 10 45 11 15Coffee breakBreakout Area11 15 13 00Lecture Practical 2 Continuum modelling Stress strain stress rate strain rate Finite element simulations Indentation test Seminar Room Aula de Seminari 13 00 14 00LunchUPF Canteen14 45 15 45Lecture Practical 3 Modelling activity active gel models Finite element simulations of mechanical patterning Seminar Room Aula de Seminari 15 45 16 15Coffee breakBreakout Area16 15 19 00Group Project PresentationsSeminar Room Aula de Seminari 19 00 20 00Final wrap up discussionSeminar Room Aula de Seminari 21 00 22 30Dinner FarewellH10 Marina Practical Information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the hotel to the venue Academia 450PhD Student 450Industry 1000 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses and Workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at a nearby hotel for the default dates of 18 June to 23 June 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfast Local transport The hotel is just an 8 minute walk from the Collaboratorium space where the practical course will be held Further details Address Hotel H10 Marina Olympic Village Av del Bogatell 64 68 08005 Barcelona Spain Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Katie Bentley, James Sharpe, Alejandro Torres-Sánchez

15 June 2023

Utilising GPUs in scientific algorithms

Description Nowadays GPU programming plays an important role in software development The massive parallel hardware enables us to analyze bigger datasets process data in finer details or visualize simulations in real time Still due to the programming complexity and the lack of knowledge GPUs are not regularly used in many scientific fields Thankfully GPU programming matures and provides simpler tools to utilize GPU hardware In this presentation we describe multiple GPU programming frameworks ranging from high level to low level and showcase them on selected bioinformatics algorithms About the speaker Adam melko is a third year doctoral student in the Department of Distributed and Dependable Systems at Charles University in Prague with the dissertation topic of Employing parallel computing in data intensive tasks He specializes in GPU programming and in the analysis of memory accesses in programs His current research topic involves development of tools for effective memory layouts and traversals of data structures...

Adam Smelko

12 June - 15 June 2023

Life at the periphery: mechanobiology of the cell surface

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview After a very engaging virtual first edition in 2021 this hybrid symposium on cell surface mechanics will bring together researchers across kingdoms of life interested in dynamic processes occurring at the cell surface The focus will be on new technologies that empower studies of cell wall cytoskeleton and membrane biology such as advanced imaging in in vitro and in vivo systems as well as approaches combining molecular biology with computational and biophysical approaches The first edition started building a much needed bridge between the wall and wall less fields This edition will cement that bridge but turn the focus to the balance between keeping a particular cell morphology necessary for function while allowing the dynamic processes that must occur at the cell surface The goal is to inspire and induce collaborations across these communities to reach a comprehensive understanding of the biology at the cell surface integrating cell wall actin and membrane biochemistry and biophysics with cell mechanics Topics In vitro reconstitution of the cell surface Cell surface in a single cell Planetary mechanobiology Cell surface mechanics in multicellular systems Modelling the cell surface What past participants say about the symposium Life at the Periphery was a rewarding opportunity to connect with people across the world and see some amazing science I really appreciated in the different sessions how the organizers worked hard to pair seemingly different topics fields of research together it made us see the common threads of interest we have in different domains of biology Michael Henderson Institut Curie Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Patricia Bassereau Institut Curie France Buzz Baum MRC Laboratory of Molecular Biology UK Peter Bieling Max Planck Institute of Molecular Physiology Germany Sandra Citi University of Geneva Switzerland Alba Diz Mu oz EMBL Heidelberg Germany Anna Erzberger EMBL Heidelberg Germany Lillian Fritz Laylin University of Massachusetts Amherst USA Anja Geitmann McGill University Canada KC Huang Stanford University USA Chien Jung Lo National Central University Taiwan Satyajit Mayor National Centre for Biological Sciences India Bela Mulder AMOLF Netherlands Dyche Mullins University of California San Francisco USA Alexandre Persat EPFL Switzerland Hawa Racine Thiam Stanford University USA Virtual Pere Roca Cusachs Soulere Institute for Bioengineering of Catalonia IBEC Spain Enrique Rojas New York University USA Katja R per MRC Laboratory of Molecular Biology UK Jakub Sedzinski Novo Nordisk Foundation Center for Stem Cell Medicine reNEW Denmark Carolina Tropini The University of British Columbia Canada Viola Vogel ETH Z rich Switzerland Kirsty Wan University of Exeter UK Scientific organisers Alba Diz Mu oz EMBL Heidelberg Germany Zemer Gitai Princeton University USA KC Huang Stanford University USA Ewa Paluch University of Cambridge UK Conference organiser Maria Mercedes Bacadare Goitia EMBL Heidelberg Germany Programme Got something to say Tweet it EESCellSurface Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk and the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 12 June 2023 Time Europe Berlin Speaker12 30 14 00Registration and light refreshments14 00 14 15Opening remarks14 15 18 30Session 1Chair Alexandre Persat EPFL Switzerland14 15 14 45Cell adhesion and spreading on fluid membranes through microtubules dependent mechanotransductionPatricia Bassereau Institut Curie France14 45 15 15Physical and embodied intelligence at the ciliated surfaceKirsty Wan University of Exeter UK15 15 15 30Plasma membrane shape homeostasis in response to cell stretchAnabel Lise Le Roux Institute for Bioengineering of Catalonia Spain15 30 16 00Chytrid fungi differentiate from cell types with an animal like actin cortex to cells with actin patches and a fungal cell wallLillian Fritz Laylin University of Massachusetts Amherst USA16 00 16 45Coffee Break and Meet the speakers 16 45 17 15Getting stressed versus going with the flow the mechanical and diffusive properties of the bacterial cell envelopeKC Huang Stanford University USA17 15 17 30Hydrogel based Molecular Tension Fluorescence Microscopy for Investigating Integrin mediated Rigidity SensingZheng Liu Wuhan University China17 30 17 45Waves on the surface of rewired oocytes membrane patterning and cytoskeletal biomechanicsAndrew Goryachev University of Edinburgh United Kingdom17 45 18 00Aberrant cortex contractions impact mammalian oocyte qualityElvira Nikalayevich Center for Interdisciplinary Research in Biology Coll ge de France France18 00 18 30From the cell surface to the nucleus through integrins and intermediate filamentsPere Roca Cusachs Soulere Institute for Bioengineering of Catalonia and University of Barcelona Spain18 30 20 00Dinner in Canteen 20 00 21 30Drinks in ATC Roof top lounge Day 2 Tuesday 13 June 2023 Time Europe Berlin Speaker09 00 12 00Session 2Chair Lillian Fritz Laylin University of Massachusetts Amherst USA09 00 09 30Probing bacterial cell wall growth by tracing wall anchored protein complexesChien Jung Lo National Central University Taiwan09 30 09 45Mechanical polarity of the cell cortexAnumita Jawahar PMMH ESPCI Institut Curie France09 45 10 00Membrane to cortex attachment determines different mechanical phenotypes in LGR5 and LGR5 colorectal cancer cellsSefora Conti Institute for Bioengineering of Catalonia Spain10 00 10 30Coffee Break and Meet the speakers 10 30 11 00Multi scale control of structural functionality in plantsAnja Geitmann McGill University Canada11 00 11 15Contribution of cell mechanics in promoting supracellular migrationSelena Gupta New York University United States of America11 15 11 30Hepatocyte apical bulkheads provide a mechanical means to oppose bile pressureMatthew Bovyn Max Planck Institute for Cellular Biology and Genetics Germany11 30 12 00A molecular view on the control of actin turnover by phosphate releasePeter Bieling Max Planck Institute of Molecular Physiology Germany12 00 12 25Flash talks 2 minutes 1 slide per talk 49 Sebastian Aland 51 Raul Aparicio Yuste 53Natalia Baranova 55 Catherine Villard 57 Andrea Disanza 59 Jaime Fernandez Sobaberas 61 Carolin Gierse 63 Xiangfu Guo 65 Saurabh Kaushik and 69 Jesus Lopz Gay Orts12 25 13 25Lunch13 25 14 25Panel Discussion ChatGPT or Family and science discussion14 25 17 25Session 3Chair Carolina Tropini The University of British Columbia Canada14 25 14 55Sub surface activities the role of the cortical microtubule cytoskeleton in regulating plant cell growth and divisionBela Mulder AMOLF Netherlands14 55 15 10ERK activation waves are key drivers in the mechanical cell competition that leads to collective onslaught of bacterially infected cellsLara Hundsdorfer University of T bingen Germany15 10 15 25Bacterial adhesion on the apical cell surface modifies the traction force field on the basal side through a new actomyosin structure called ancreopodiaDaria Bonazzi Institut Pasteur France15 25 15 55Coffee Break and Meet the speakers 15 55 16 25Multiciliated cells use filopodia to probe tissue mechanics during epithelial integration in vivoJakub Sedzinski Novo Nordisk Foundation Center for Stem Cell Medicine reNEW Denmark16 25 16 40Dual roles of catenin in signaling and cell cell junction maintenance in the intestinal epitheliumAndrew Clark University of Stuttgart Germany16 40 16 55The stability of Arp2 3 nucleated actin filamentsLuYan Cao The Francis Crick Institute United Kingdom16 55 17 25Cellular Biophysics of Membranes Remodeling and Rupture Lessons from NETosisHawa Racine Thiam Stanford University USA Remote speaker 17 25 17 55Flash talks 2 minutes 1 slide per talk 71 Xinwen Miao 73 Alexander Dulebo 75 Priyanka Roy 77 Jan Sabo 79 Gautham Hari Sankara Narayana 81 Lan Jiang 83 Oscar Stassen 85 Joseph Vermeil 87 Hannes Vogler 89 Arash Yahyazadeh Shourabi and 91 Andrew Zhao17 55 19 25Poster Session 1 odd numbers 19 25 20 25Dinner in Canteen20 25 21 30Drinks in ATC Roof top lounge Day 3 Wednesday 14 June 2023 Time Europe Berlin Speaker09 00 12 00Session 4Chair Jakub Sedzinski Novo Nordisk Foundation Center for Stem Cell Medicine reNEW Denmark09 00 09 30Molecular mechanobiology of the extracellular matrixViola Vogel ETH Z rich Switzerland09 30 09 45Polarity driven three dimensional spontaneous rotation of a cell doubletQuentin Vagne University of Geneva Switzerland09 45 10 15Mechanobiology of tight junctionsSandra Citi University of Geneva SwitzerlandNot available on demand10 15 10 45Coffee Break and Meet the speakers10 45 11 00Interacting systems for complex cell wall patterns with special functionsEva Deinum Wageningen University Research The Netherlands11 00 11 15Membrane reshaping across the tree of lifeFelix Frey Institute of Science and Technology Austria Austria11 15 11 30Modelling macropinocytic cup formation and closure informed by lattice light sheet microscopy dataJudith Lutton University of Warwick United Kingdom11 30 12 00Inoviruses in the gut microbiota release without bacterial lysisCarolina Tropini The University of British Columbia Canada12 00 12 25Flash talks 2 minutes 1 slide per talk 50 Luca Andronico 52 Bin Qu 54 Golnar Kolahgar 56 Srishti Dar 58 Jenna Elliott 60 Sherman Foo 62 David Gomez 64 Kyojiro N Ikeda 66 Mengya Kong and 68 Jia Hui Li12 25 13 25Lunch13 25 16 55Session 5Chair Peter Bieling Max Planck Institute of Molecular Physiology Germany13 25 13 55The skin of a living cell a mechanoresponsive membraneSatyajit Mayor National Centre for Biological Sciences India13 55 14 10Cytoskeleton mediated spatial accommodation shapes lateral root morphogenesisDorothee St ckle University of Zurich Switzerland14 10 14 25Mechanisms and mechanics at the cell surface driving epithelial tube formationMatteo Rauzi University C te d Azur CNRS Inserm iBV Nice France14 25 14 55Bacteria mechanosense surfaces to guide motility and biofilm formationAlexandre Persat EPFL Switzerland14 55 15 25Coffee Break and Meet the speakers15 25 15 55The evolutionary mechanics of microbial morphogenesisEnrique Rojas New York University USA15 55 16 10Fast remodeling of surface cytoskeleton underlie phenotypic switches in the closest relatives of animalsThibaut Brunet Institut Pasteur FranceNot available on demand16 10 16 25Nanoscale Membrane Topography Engineering in cells in vitro and in between Wenting Zhao Nanyang Technological University Singapore16 25 16 55Interplay between cell surface mechanics and contact dependent signalingAnna Erzberger EMBL Heidelberg Germany16 55 17 20Flash talks 2 minutes 1 slide per talk 72 Marie Muenkel 74 Nicolas Roby 76 Francois Fagotto 78 Julio Cesar Sanchez Rendon 80 Annika Sa 82 Vui Yin Seow 84 Abdul Basith Tanari 86 Filipe Vicente 88 Steve Caplan and 90 Cheng han Yu17 20 18 50Poster Session 2 even numbers 18 50 20 20Conference Dinner20 20 23 00Conference Party Day 4 Thursday 15 June 2023 Time Europe Berlin Speaker09 15 14 15Session 6Chair Anna Erzberger EMBL Heidelberg Germany and Ewa Paluch University of Cambridge UK09 15 09 45More than the sum How does a composite interface govern function at the cell surface Alba Diz Mu oz EMBL Heidelberg GermanyNot available on demand09 45 10 00PPP2R1A Regulates Migration Persistence through the NHSL1 containing WAVE Shell ComplexYanan Wang cole Polytechnique France10 00 10 15Chitosan glycerol blended micro structured membranes for the enhancement of peripheral nerve regenerationLuca Scaccini Scuola Normale Superiore Italy10 15 10 30Organic semiconductors for modulation of mechano sensitive channels in MDCK cellsVanessa Spagnolo Istituto Italiano di Tecnologia Italy10 30 10 45Staying in touch septate junctions and epithelial sampling in the Drosophila cropJason Millington Stanford University United States of America10 45 11 15Coffee Break and Meet the speakers 11 15 11 45The final cut ESCRT III in cell division from archaea to eukaryotesBuzz Baum MRC Laboratory of Molecular Biology UK11 45 12 00 Cracking the gut epithelium junctional rupture at the interface of two different cell typesJustine Creff Molecular Cellular and Developmental Biology France12 00 13 00Lunch13 00 13 30Coordinating morphogenetic events supracellular actomyosin cables as mechanical insulatorsKatja R per MRC Laboratory of Molecular Biology UK13 30 13 45Hechtian strands The threads for mechanosensing in plant cells Denise Arico Laboratoire de Recherche en Sciences V g tales Universit de Toulouse CNRS Laboratoire Reproduction et D veloppement des Plantes ENS Lyon INRAe France13 45 14 15The molecular mechanism of force feedback in lamellipodial actin networksDyche Mullins University of California San Francisco USA14 15 14 30Closing Remarks and Poster Prize14 30 14 45Departures Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Maria Bacadare for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Monday 15 May 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 05 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Boarding HouseMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Conference shuttle bus schedule The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Where is the nearest COVID 19 test centre Wo ist das n chste COVID 19 Testzentrum Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsor Molecular Machines Industries MMI Media partners EMBO Journal an EMBO Press journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Journal of Cell Science a The Company of Biologists journal Open Biology a Royal Society journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 x90...

Alba Diz Muñoz, Zemer Gitai, KC Huang, Ewa Paluch

12 June - 16 June 2023

Summer school in bioinformatics

Description This course provides an introduction to the use of bioinformatics in biological research giving participants guidance for using bioinformatics in their work whilst also providing hands on training in tools and resources appropriate to their research Participants will initially be introduced to bioinformatics theory and practice including best practices for undertaking bioinformatics analysis data management and reproducibility To enable specific exploration of resources in their particular field of interest participants will then be divided into focused groups to work on a project Participants will be required to review some pre recorded material prior to the start of the course Group projects A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI and external institutes This allows people to explore the bioinformatics tools and resources available in their area of interest and apply them to a set problem providing participants with hands on experience relevant to their own research The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of working with biological data Groups are mentored and supported by the trainers who set the initial challenge but the groups will be responsible for driving their projects forward with all members expected to take an active role Groups are pre organised before the course and all group members will be sent some short homework in preparation for their project work prior to the start of the course Basic outlines of the projects on offer this year are given below In your application you must indicate your first and second choice of project based on which you think would benefit your research most Not all projects may be offered and final decisions on which projects will be run during the course will be made based on the number of applicants per project Most of the projects cover mammalian data sets however in many cases the methods and approaches taught are transferable to data from various species Group project one Genome variation across human populations Natural variation between individuals or between different human populations is a result of genome mutations throughout evolutionary history Some mutations may become fixed because of their beneficial effect while most drift among individuals During this project you will investigate genomic variation between two separate human populations of European and Asian descent Using sequence data from a number of individuals from each population you will use a range of bioinformatics tools to discover variants that exist between them In the second section of the project you will attempt to analyse the functional consequences of the variants you have identified attempting to find clinical association and linking them to phenotypes Project mentor Baron Koylass EMBL EBI Group project two Interpreting functional information from large scale protein structure data This project will introduce you to the wealth of publicly available data in the Protein Data Bank PDB and give you the opportunity to investigate how large subsets of structure data can be used to analyse protein features and determine function In the project you will learn how to identify relevant protein structures collate and interpret functional information and implement this process programmatically Project mentor Preeti Choudhary EMBL EBI Marcus Bage EMBL EBI Group project three Modelling cell signalling pathways Curating models of biological processes is an effective training in computational systems biology where the curators gain an integrative knowledge of biological systems modelling and bioinformatics You will learn to encode and simulate ordinary differential equation models of signalling pathways from a recent publication using user friendly software such as COPASI even without extensive mathematical background You will learn to perform in silico experiments new predictions and develop hypotheses Furthermore you will learn how to annotate models and re use pre existing models from open repositories such as BioModels Project mentors Rahuman Sheriff EMBL EBI Krishna Tiwari EMBL EBI Group project four Networks and pathways This project will cover typical bioinformatics analysis steps needed to put differentially expressed genes into a wider biological context You will start with gene expression data RNA seq to build an initial interaction network Next you will learn to combine public network datasets identify key regulators of biological pathways and explore biological function through network analysis You will get first hand experience in integration and co visualising with additional data and functional enrichment analysis All this helps to put the initial results into a previously known context and provide hypotheses for potential follow up experiments We will use Cytoscape Expression Atlas g Profiler StringDb among other tools We also may give a few R packages a try Project mentor Priit Adler University of Tartu Group project five Reusing FAIR Bioimage data an AI application Biological imaging is a rapidly growing field with a vast potential of re use for further scientific research and development Re use of bioimage data requires FAIR Findable Accessible Interoperable Reusable data by public repositories that support FAIR sharing such as the BioImage Archive This project aims to showcase one of many ways of reusing bioimage data by applying artificial intelligence AI models on selected datasets in the BioImage Archive In this project you will learn to search and download the extensive variety of data that is held in this publicly available data resource You will also use Jupyter Python notebooks to visualise image data in the archive and deploy AI models on selected datasets Project mentors Aybuke Kupcu Yoldas EMBL EBI Teresa Zulueta Coarasa EMBL EBI Additional information Please note that we will operate this course face to face at EMBL EBI in Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic...

Sophie Spencer

11 June - 16 June 2023

Quantitative proteomics: strategies and tools to probe biology

Description OverviewSpeakersProgrammePractical InformationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview This course will provide both theoretical and practical training in the use of quantitative proteomics Participants will learn the principles of the most frequently used data acquisition methods DDA DIA and targeted proteomics and proteomic quantification approaches label free SILAC and TMT The major aim of this course is to practically train the participants in the use of readily available bioinformatic tools as well as in the statistical interpretation of proteomic data in order to empower them to make informed decisions in their own research Audience This course is aimed at researchers who know the basics of proteomics and who want to get a deeper understanding of quantitative methodologies and at those who are familiar with wet lab proteomic experimentation but want to gain experience in bioinformatic data interpretation To enter the course a basic understanding of mass spectrometry based proteomics is beneficial Modules resources The principles of proteome quantification by stable isotope labeling SILAC and TMT label free and targeted proteomics Introduction how various types of mass spectrometers can be used for proteome quantification Computer training sessions using software tools for the analysis of various quantitative proteomic data types Lectures demonstrating the application of quantitative proteomics in biology clinical research and drug discovery Learning outcomes Understand the principles and use cases of quantitative proteomic methods Ability to design quantitative proteomic experiments including selection of the most appropriate hardware and software Ability to analyse quantitative proteomic data by various software tools Speakers Speakers trainers and staff Miriam Abele Technical University Munich Germany Tine Claeys Ghent University Belgium Dominic Helm German Cancer Research Center Germany Devon Kohler Northeastern University USA Jeroen Krijgsveld German Cancer Research Center and Heidelberg University Germany Janne Lehti Karolinska Institute Sweden Kathryn Lilley University of Cambridge UK Fan Liu Leibniz Forschungsinstitut f r Molekulare Pharmakologie Germany Christina Ludwig Technical University Munich Germany Lennart Martens Ghent University Belgium Julia Mergner Technical University Munich Germany Shabaz Mohammed University of Oxford UK Alexey Nesvizhskii University of Michigan Medical School USA Ilaria Piazza Max Delbr ck Center Germany Daniel Polasky University of Michigan Medical School USA Pablo Andres Rivera Mej as EMBL Heidelberg Germany Mikhail Savitski EMBL Heidelberg Germany Frank Stein EMBL Heidelberg Germany Olga Vitek Northeastern University USA Scientific organisers Jeroen Krijgsveld German Cancer Research Center and Heidelberg University Germany Christina Ludwig Technical University Munich Germany Mikhail Savitski EMBL Heidelberg Germany Course organisers Aline Schnieder Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it with EMBOQuantPro Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 11 June 2023 Time Europe Berlin SessionLocation13 00Bus to EMBL ATCISG Hotel13 30 14 00Registration welcome and housenotesCourtyard Room A B14 00 14 45Introduction Quantitative proteomics for biologyJeroen Krijgsveld German Cancer Research Center DKFZ University of Heidelberg GermanyChristina Ludwig Technical University Munich GermanyMikhail Savitski EMBL Heidelberg GermanyCourtyard Room A B14 45 16 00Lecture Peptide chromatography in proteomics remote lecture Shabaz Mohammed University of Oxford UKCourtyard Room A B16 00 16 30Coffee BreakCourtyard Room A B16 30 17 30Flash talks 1 odd numbers Courtyard Room A B17 30 19 00Poster Session odd numbers with drinks and snacksHelix B19 00 20 00DinnerEMBL Canteen20 00Bus to ISG HotelATC entrance Day 2 Monday 12 June 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Lecture MS technologiesDominic Helm German Cancer Research Center DKFZ GermanyCourtyard Room A B10 05 11 20Lecture Peptide and protein identificationLennart Martens Ghent University BelgiumCourtyard Room A B11 20 11 35Coffee BreakCourtyard Room A B11 35 12 35Practical session 1 Peptide and protein identificationLennart Martens Ghent University BelgiumMiriam Abele Technical University Munich GermanyTine Claeys Ghent University BelgiumChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab12 35 13 35LunchEMBL Canteen13 35 15 05Practical session 1 cont Peptide and protein identificationLennart Martens Ghent University BelgiumMiriam Abele Technical University Munich GermanyTine Claeys Ghent University BelgiumChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab15 05 16 20Coffee break and Lab tourCourtyard Room A B Proteomics Core Facility16 20 17 20Flash talks 2 even numbers Courtyard Room A B17 20 18 20Application talk 1 Cancer proteogenomicsJanne Lehti Karolinska Institute SwedenCourtyard Room A B18 20 19 20DinnerEMBL Canteen19 20 20 50Poster Session even numbers with drinks and snacksHelix B20 50Bus to ISG HotelATC entrance Day 3 Tuesday 13 June 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 35Lecture Introduction to label free quantification by DIA SWATHChristina Ludwig Technical University Munich GermanyCourtyard Room A B10 35 11 05Coffee BreakCourtyard Room A B11 05 12 35Practical session 2 Label free protein quantification by DIA SWATHMiriam Abele Technical University Munich Germany Jeroen Krijgsveld German Cancer Research Center DKFZ University of Heidelberg Germany Christina Ludwig Technical University Munich Germany Julia Mergner Technical University Munich Germany Mikhail Savitski EMBL Heidelberg GermanyComputer Training Lab12 35 13 35LunchEMBL Canteen13 35 15 35Practical session 2 cont Label free protein quantification by DIA SWATHMiriam Abele Technical University Munich Germany Jeroen Krijgsveld German Cancer Research Center DKFZ University of Heidelberg Germany Christina Ludwig Technical University Munich Germany Julia Mergner Technical University Munich Germany Mikhail Savitski EMBL Heidelberg GermanyComputer Training Lab15 35 16 05Coffee BreakCourtyard Room A B16 05 17 05Application talk 2 Spatial and sub cellular proteomicsKathryn Lilley University of Cambridge UKCourtyard Room A B17 05 18 05Application talk 3 Versatility of SILAC labeling to understand proteome dynamicsJeroen Krijgsveld German Cancer Research Center DKFZ University of Heidelberg GermanyCourtyard Room A B18 05 19 00DinnerEMBL Canteen19 00Bus to ISG HotelATC entrance Day 4 Wednesday 14 June 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Lecture Introduction of MSFragger for analysis of TMT dataAlexey Nesvizhskii University of Michigan USACourtyard Room A B10 05 12 05Practical session 3 Analysis of TMT and PTM data with MSFraggerAlexey Nesvizhskii University of Michigan USADaniel Polasky University of Michigan USAChristina Ludwig Technical University Munich GermanyMikhail Savitski EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyComputer Training Lab12 05 13 05LunchEMBL Canteen13 05 14 35Practical session 3 cont Analysis of TMT and PTM data with MSFraggerAlexey Nesvizhskii University of Michigan USADaniel Polasky University of Michigan USAChristina Ludwig Technical University Munich GermanyMikhail Savitski EMBL Heidelberg GermanyFrank Stein EMBL Heidelberg GermanyComputer Training Lab14 35 15 05Coffee BreakCourtyard Room A B15 05 16 05Open discussion Agenda to be set by course participantsCourtyard Room A B16 05 17 05Application talk 4 Stability proteomicsMikhail Savitski EMBL Heidelberg GermanyCourtyard Room A B17 05 18 05Meet the speaker session with drinks and snacksCourtyard Room A B18 05Free eveningBus downtown via ISG HotelEMBL bus stop Day 5 Thursday 15 June 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 35Lecture Introduction to statistical analysis of proteomics dataOlga Vitek Northeastern University USACourtyard Room A B10 35 11 05Coffee BreakCourtyard Room A B11 05 12 35Practical session 4 Statistical analysis of proteomics data using MSStatsOlga Vitek Northeastern University USAMiriam Abele Technical University Munich GermanyDevon Kohler Northeastern University USAChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab12 35 13 35LunchEMBL Canteen13 35 15 35Practical session 4 cont Statistical analysis of proteomics data using MSStatsOlga Vitek Northeastern University USAMiriam Abele Technical University Munich GermanyDevon Kohler Northeastern University USAChristina Ludwig Technical University Munich GermanyJulia Mergner Technical University Munich GermanyComputer Training Lab15 35 16 05Coffee breakCourtyard Room A B16 05 17 05Application talk 5 Allosteric proteomicsIlaria Piazza MDC Berlin GermanyCourtyard Room A B17 05 17 45Bus downtown via ISGEMBL bus stop17 45 19 15Guided city tour19 30 21 30Course dinner Day 6 Friday 16 June 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Application talk 6 Structural interactomicsFan Liu Leibniz Forschungsinstitut f r Molekulare Pharmakologie FMP GermanyCourtyard Room A B10 05 12 35Breakout sessions Discussion in groupsCourtyard Room A B Flex Lab A B12 35 13 35LunchEMBL Canteen13 35 15 35Presentations from breakout session Panel discussionCourtyard Room A B15 35 16 05Recap and FarewellCourtyard Room A B16 05Bus to train station via ISGATC entrance Practical Information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of 11 to 16 June 2023 5 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 31 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Jeroen Krijgsveld, Christina Ludwig, Mikhail Savitski

8 June 2023

Improving the accessibility of the EMBL-EBI website: background, process, and lessons

Description In the last couple of years there has been an increased interest in digital accessibility at EMBL EBI and our parent organisation EMBL In this webinar we will share how we have been making the case for accessibility and how we have made the EMBL EBI home page move to the top 1 for accessibility among the 1 000 000 most visited home pages in 2023 We will include practical tips on how to incorporate accessibility in the design and development process and share the lessons that we learned For more information please read this article written by Nikiforos Karamanis About the speakers Dr Nikiforos Karamanis is a Senior User Experience UX Designer at EMBL EBI who enjoys spending time with users developers and other stakeholders and helping them work together to achieve their goals using Lean UX methods He is the Product Owner of EMBL s Design System which provides components to build life science websites that follow best UX practices and meet accessibility standards Carla Oliveira is a UX Designer currently working at EMBL EBI in the Web development team In her role she applies her expertise to help design intuitive and user friendly interfaces for scientific and bioinformatics applications Carla s work involves collaborating with scientists researchers and developers to ensure that the complex data and tools provided by the institute are easily accessible and understandable to users...

5 June - 9 June 2023

Deep learning for image analysis

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview The advent of deep learning has brought a revolution in the field of computer vision including most tasks and research questions concerned with microscopy image analysis Neural networks have been successfully used for image restoration classification and segmentation for the detection of objects and characterisation of their morphology for high throughput imaging and large scale processing in 3D Despite these advances training and deployment of such neural networks remains difficult for practitioners of image analysis The aim of our course is to close this gap and teach the participants in the most hands on way possible to apply deep learning based methods to their own data and image analysis problems Participants are invited to bring their own data sets that can be used in the practical sessions Audience This course is aimed at both core facility staff and research scientists Prerequisites for this workshop are programming skills in Python and ideally Tensorflow Keras or Pytorch as well as basic knowledge of machine learning theory Learning outcomes After this course you should be able to Understand the fundamentals of machine learning methods suitable for image analysis Advise users colleagues in strategies to obtain ground truth Train and use a CNN for a bioimage analysis task studied in the course Perform simple quality control on the results What past participants say about the course I enjoyed every single day of this course not only have I learned so much on how to approach an image analysis problem using Deep Learning but also I had a great great great time coding and discussing with the other participants and the instructors Lucrezia Ferme Instituto Gulbenkian de Ci ncia Portugal What is the greatest benefit of the course for the scientific community and what could the techniques in this course be used for in the bigger picture Find out more and meet organiser Anna Kreshuk in our 2019 Meet the trainer series interview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Anwai Archit University of G ttingen Germany Elena Buglakova EMBL Heidelberg Germany Benjamin Gallusser EPFL Switzerland Valentin Gilet University of Angers France Jean Karim H rich EMBL Heidelberg Germany Anna Kreshuk EMBL Heidelberg Germany Constantin Pape University of G ttingen Germany Pejman Rasti University of Angers and ESAIP France David Rousseau University of Angers France Uwe Schmidt Independent researcher Germany Yi Sun EMBL Heidelberg Germany Martin Weigert EPFL Switzerland Valentyna Zinchenko EMBL Heidelberg Germany Scientific organisers Anna Kreshuk EMBL Heidelberg Germany Constantin Pape University of G ttingen Germany Pejman Rasti University of Angers and ESAIP France David Rousseau University of Angers France Martin Weigert EPFL Switzerland Course organisers Catherine Casas Course and Conference Officer EMBL Heidelberg Germany Irena Provaznikova Training Laboratory Officer EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLDeepLearning Pre course work will be needed ahead of the three mandatory webinars that will take place before the course Further details will be shared in advance of the course and materials will be available on the EMBL eCampus platform Some speakers may need to join virtually to give their lecture or Q A Programme is preliminary and subject to change The course programme includes three mandatory virtual pre course webinars The purpose of the webinars is to get everyone to the level from which we can start trying things on real data Pre course webinar 1 Monday 8 May 2023 11 00 12 00 CET Pre course webinar 2 Monday 15 May 2023 11 00 12 00 CET Pre course webinar 3 Monday 22 May 2023 11 00 12 00 CET Day 1 Monday 5 June 2023 Time Europe Berlin SessionLocation11 45 12 00Bus from hotel to EMBL ATC entranceISG Hotel12 00 12 30Arrival and registrationCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 14 00Welcome and house notes and course overviewCourtyard Room A B14 00 15 00Participants present their data and problem at hand 2 min each Courtyard Room A B15 00 15 30Coffee BreakCourtyard Room A B15 30 16 30Lecture Semantic segmentationAnna Kreshuk EMBL Heidelberg GermanyCourtyard Room A B16 30 17 00Meet the instructors and introduction to the practicalsCourtyard Room A B17 00 19 00Practical session Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab19 00 19 15Departure to HotelEMBL Bus Stop19 15 20 15DinnerISG Hotel Day 2 Tuesday 6 June 2023 Time Europe Berlin SessionLocation08 40 09 00Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Lecture Instance segmentationConstantin Pape University of G ttingen GermanyCourtyard Room A B10 05 10 15Coffee breakCourtyard Room A B10 15 11 15Lecture Data augmentation strategiesDavid Rousseau University of Angers FranceCourtyard Room A B11 15 11 35Coffee breakCourtyard Room A B11 35 12 35Practical session Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab12 35 13 35Lunch breakEMBL Canteen13 35 15 35Practical session Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab15 35 16 00Coffee breakCourtyard Room A B16 00 18 00Practical session Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab18 00 19 00DinnerEMBL Canteen19 00 19 15Bus to ISG HotelEMBL Bus Stop Day 3 Wednesday 7 June 2023 Time Europe Berlin SessionLocation08 40 09 00Bus from hotel to EMBL ATC Entrance ISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Lecture Image Denoising Martin Weigert EPFL SwitzerlandCourtyard Room A B10 05 10 15Coffee breakCourtyard Room A B10 15 11 15Lecture How to approach a deep learning project speaking from experienceDavid Rousseau University of Angers FranceCourtyard Room A B11 15 11 35Coffee breakCourtyard Room A B11 35 12 35Practical Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab12 35 13 35LunchEMBL Canteen13 35 13 50Group photo13 50 17 45Practical Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab17 45 18 10Bus to DowntownEMBL Bus Stop18 10 20 00Free time20 00 23 00Dinner DowntownKulturbrauerei Heidelberg Day 4 Thursday 8 June 2023 Time Europe Berlin SessionLocation08 40 09 00Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 10 05Lecture Overview of GUI based deep learning tools and how you can make use of themPejman Rasti University of Angers FranceCourtyard Room A B10 05 10 15Coffee breakCourtyard Room A B10 15 11 15Practical Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab11 15 11 35Coffee breakCourtyard Room A B11 35 12 35Practical Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab12 35 13 35Lunch breakEMBL Canteen13 35 16 05Practical Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab16 05 16 35Coffee breakCourtyard Room A B16 35 19 05Practical Focus on own dataCourtyard Room A B FlexLabs A B and Computer Training Lab19 05 21 05Pizza dinner and roundtable discussionEMBL ATC Rooftop Lounge21 05 21 15Bus to ISG HotelEMBL Bus Stop Day 5 Friday 9 June 2023 Time Europe Berlin SessionLocation08 40 09 00Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 05Overview of the dayCourtyard Room A B09 05 11 45Group activity Finish practicals preparation of presentationsCourtyard Room A B11 45 12 45Lunch breakEMBL Canteen12 45 14 10Group activity Presentations by the participants what worked what didn t what could be done next I Courtyard Room A B14 10 14 20Coffee breakCourtyard Room A B14 20 15 45Group activity Presentations by the participants what worked what didn t what could be done next II Courtyard Room A B15 45 16 00Wrap up and DeparturesCourtyard Room A B16 00 16 30Bus to Heidelberg Train StationEMBL Bus Stop Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 690PhD Student 690Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights 4 9 June 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code MAC23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed Participants are invited to bring their own data sets that can be used in the practical sessions Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event Supporters Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Anna Kreshuk, Constanin Pape, Pejman Rasti, Daid Rousseau, Martin Weigert

4 June - 7 June 2023

The ageing genome: from mechanisms to disease

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Time stands still for no one or for no molecule for that matter Of the molecules that undergo changes over time it is chromosomal alterations that may have some of the most profound and long lasting cellular and organismal effects In contrast to any other macromolecule the genome is irreplaceable and requires constant repair Despite sophisticated genome maintenance mechanisms DNA damage accumulates over time and hence with age The ensuing chromosomal alterations may lead to genome instability somatic mutations impaired gene expression and DNA replication alterations of the epigenetic code and chromatin structure These molecular processes can impair cell function and alter cell fate thus contributing to disease tissue and organ dysfunction thus driving the ageing process of the organism Therefore to promote lifelong health it is critical to gain a better understanding of how DNA damage contributes to the ageing process and age related disease Similarly it will be vital to understand how the regulation of DNA repair and genome maintenance changes over the course of ageing Finally we need to consider how time dependent DNA alterations can impinge in gene expression and chromatin structure Together a more complete understanding of these interactions will open doors for therapeutic interventions aimed to promote healthy ageing This symposium brings together a diverse group of researchers using a breadth of experimental model systems and organisms with a focus on genome maintenance from DNA repair to chromatin regulation We hope that by looking at the genome maintenance specifically in the context of ageing we will gain insights into how chromosomal defects can be avoided or even repaired during the aging process to ensure optimal cellular function and to promote lifelong health Topics Endogenous and metabolic genotoxins Aneuploidy Loss of proteostasis Telomere dysfunction Age related disease Model systems for ageing research Senescence responses DNA repair during the ageing process Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speakers Mar a A Blasco Spanish National Cancer Research Center Spain Virtual speaker Jan H J Hoeijmakers Erasmus Medical Center Princess Maxima Center for Pediatric Oncology The Netherlands University of Cologne Germany Speakers Andrea Ablasser EPFL Switzerland Virtual speaker Vilhelm Bohr University of Copenhagen Denmark Anne Brunet Stanford University USA Anthony Cesare Children s Medical Research Institute University of Sydney Australia Fabrizio d Adda di Fagagna IFOM ETS The AIRC Institute of Molecular Oncology IGM CNR Centro Nazionale delle Ricerche Italy George Garinis Foundation of Research and Technology Hellas and the University of Crete Greece Miguel Godinho Ferreira Institute for Research on Cancer and Aging of Nice France Vera Gorbunova University of Rochester USA Brian Kennedy National University of Singapore Singapore Nils G ran Larsson Karolinska Institutet Sweden Martijn Luijsterburg Leiden University Medical Center The Netherlands Laura Niedernhofer University of Minnesota USA Stephanie Panier Max Planck Institute for Biology of Aging Germany K J Patel University of Oxford UK Agnel Sfeir Sloan Kettering Institute MSKCC USA Deborah Toiber Ben Gurion University of the Negev Israel Helle Ulrich Institute of Molecular Biology Germany Jan Vijg Albert Einstein College of Medicine USA Scientific organisers Jacqueline Jacobs The Netherlands Cancer Institute The Netherlands Ga lle Legube CBI CNRS University of Toulouse France Brian Luke Johannes Gutenberg University and Institute of Molecular Biology Germany Bj rn Schumacher University of Cologne Germany Conference organiser Nathalie Sneider EMBL Heidelberg Germany Programme Got something to say Tweet it EESAgeing Programme is preliminary and subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Please find the poster listing here Day 1 Sunday 4 June 2023 Time Europe Berlin Speaker11 45 13 15Registration and light refreshments13 15 13 30Opening remarks 13 30 14 30Keynote lecture DNA damage repair understanding aging and nutritional applications for medicine in generalJan Hoeijmakers Erasmus Medical Center Princess Maxima Center for Pediatric Oncology The Netherlands University of Cologne Germany14 30 18 00Session 1 Chair Bj rn Schumacher University of CologneGermany14 30 15 00Molecular mechanisms in transcription coupled DNA repairMartijn Luijsterburg Leiden University Medical Center The Netherlands15 00 15 15The Yin Yang sides of retrotransposons in aging and related pathologies from deleterious to target and tools for antiaging and tissue regeneration Valerio Orlando King Abdullah University of Science and Technology KAUST Saudi ArabiaNot available on demand15 15 15 30Changes in DNA double strand break repair during aging correlate with increased genomic mutations Jennifer Cobb University of Victoria Canada15 30 16 00Coffee Break and Meet the Speakers 16 00 16 30Sensing DNA as a danger signal through the cGAS STING pathwayAndrea Ablasser EPFL Switzerland Remote speaker 16 30 16 45The DREAM complex functions as master regulator of somatic DNA repair capacities Arturo Bujarrabal Dueso University of Cologne Germany16 45 17 00DBF4 Dependent Kinase DDK promotes resection of DNA double stand breaks and repair via homologous recombination Boris Pfander German Aerospace Center DLR Germany17 00 17 30The dynamic network of DSB in chromatinDeborah Toiber Ben Gurion University of the NegevIsrael17 30 18 30Speed Networking 18 30 20 00Dinner20 00 22 00After dinner drinks Day 2 Monday 5 June 2023 Time Europe Berlin Speaker09 00 12 00Session 2Chair Gaelle Legube Universit Paul SabatierFrance09 00 09 30DNA repair and anti cancer mechanisms in the longest living mammal the bowhead whale Vera Gorbunova University of Rochester USA09 30 09 45The FIGNL1 interacting protein C1orf112 is synthetic lethal with PICH and mediates RAD51 retention on chromatin Marcel van Vugt University of Groningen The NetherlandsNot available on demand09 45 10 00Post transcriptional characterization of the vertebrate aging brain shed insight on the origin of protein transcript decoupling Domenico Di Fraia Leibniz Institute on Aging Fritz Lipmann Institute FLI GermanyNot available on demand10 00 10 30Translating Longevity Interventions and DiagnosticsBrian Kennedy National University of Singapore Singapore10 30 11 00Coffee Break and Meet the Speakers11 00 11 30cGAS STING is required for senescence and aging in telomerase deficient zebrafishMiguel Godinho Ferreira Institute for Research on Cancer and Aging of Nice France11 30 11 45Characterization of epigenetic changes and genome integrity in arrested and aging oocytes across female lifespan Michael Klutstein The Hebrew University of Jerusalem Israel11 45 12 00Aging associated changes in transcriptional elongation influence longevity Andreas Beyer University of Cologne Germany 12 00 13 30Lunch13 30 16 45Session 3Chair Jacqueline Jacobs The Netherlands Cancer Institute The Netherlands13 30 14 00Telomere loops and chromosome end protectionAnthony Cesare Children s Medical Research Institute University of Sydney Australia14 00 14 15Regulation of RNA Polymerase II arrest prevents genome instability and cell death Esperanza Lisha Granado Calle Universidad de Sevilla Spain14 15 14 30Persistent TFIIH binding to DNA damage impairs in vivo neuron functionality Hannes Lans Erasmus MC The Netherlands14 30 15 00Understanding and modeling aging Anne Brunet Stanford University USANot available on demand15 00 15 30Coffee Break and Meet the Speakers 15 30 16 00Formaldehyde induced endogenous DNA damage disrupts blood regeneration nutritional homeostasis and promotes ageingK J Patel University of Oxford UK16 00 16 15Single cell whole genome sequencing after chemotherapeutic treatment reveals cell type specific mutational patterns and clonal dynamics of the regenerating blood system Lucca Derks Princess M xima Center for Pediatric Oncology Oncode Institute The Netherlands 16 15 16 30Accurate aging clocks based on accumulating stochastic variation David Meyer University of Cologne Germany16 30 16 45Programmed neuronal DNA damage and neuronal physiologyBjoern Schwer University of California San FranciscoNot available on demand16 45 17 15Flash talks odd and even numbers Edwige Belotti 51 Ronald Cutler 63 Michelle Harwood 72 Johanna Heid 73 Gabriel Neuohr 85 Cecile Otten 89 Francesca Rossiello 95 Marjolein van Sluis 10717 15 19 15Poster Session 1 odd with beer and snacksFree evening Day 3 Tuesday 6 June 2023 Time Europe Berlin Speaker09 00 12 00Session 4Chair Jacqueline Jacobs The Netherlands Cancer Institute The Netherlands09 00 09 30RHINO restricts MMEJ activity to mitosis Agnel Sfeir Sloan Kettering Institute MSKCC USA09 30 09 45Biological age of Down syndrome via IgG glycome profiles reveals 19 1 years acceleration and iPSC modelling reveals a causative mechanism Dean Nizetic Queen Mary University of London UK Not available on demand09 45 10 00Transcription coupled DNA Protein Crosslink repair by non canonical TC NER Jurgen Marteijn Erasmus MC The Netherlands 10 00 10 30Therapeutic opportunities in age related disordersFabrizio d Adda di Fagagna IFOM ETS The AIRC Institute of Molecular Oncology IGM CNR Centro Nazionale delle Ricerche Italy10 30 11 00Coffee Break and Meet the Speakers 11 00 11 30DNA damage and innate immune responses during ageingGeorge Garinis Foundation for Research and Technology Hellas University of Crete Greece11 30 11 45Investigating centromere organization during senescence and the role of innate immune activator cGAS at centromeres Camelia Chakraborty Institut Curie France 11 45 12 00G quadruplex DNA structure an epigenetic alteration of accelerated aging Robert H nsel Hertsch University of Cologne Germany Not available on demand12 00 13 30Lunch12 30 13 15Career Workshop ATC Auditorium Moderator Rachel GrafPanelists Anthony Cesare Children s Medical Research Institute University of Sydney AustraliaAgnel Sfeir Sloan Kettering Institute MSKCC USAHelle Ulrich Institute of Molecular Biology Germany13 30 16 30Session 5Chair Gaelle Legube Universit Paul SabatierFrance13 30 14 00DNA damage signaling to mitochondria in neurodegeneration and agingVilhelm Bohr University of Copenhagen Denmark14 00 14 15BTG3 participates in the GG NER pathway by regulating XPC for efficient repair of UV induced DNA lesions Sheau Yann Shieh Academia Sinica Taiwan14 15 14 30Study of the dynamic changes of double strand break sensor proteins interactome during DNA damage response Alfredo Garcia Venzor Ben Gurion University of the Negev IsraelNot available on demand14 30 15 00The contribution of endogenous DNA damage to age related diseasesLaura Niederhofer University of Minnesota USA15 00 15 30Coffee Break and Meet the Speakers 15 30 16 00Potential functions of the cytoskeleton in DNA repair and the replication stress responseHelle Ulrich Institute of Molecular Biology GermanyNot available on demand16 00 16 15Aging is associated with a systemic length associated transcriptome imbalance Thomas Stoeger Northwestern University USA16 15 16 30Single cell multiomics unveils heterogeneous landscape of mosaic structural variants associated with myeloid and primitive CD34 cells Jan Korbel EMBL Heidelberg GermanyNot available on demand16 30 17 00Break17 00 19 00Poster Session 2 even with beer and snacks19 00 21 00Conference Dinner21 00 23 00Conference Party Day 4 Wednesday 7 June 2023 Time Europe Berlin Speaker09 00 12 45Session 6Chair Brian Luke Mainz UniversityGermany09 00 09 30Drugging mtDNA transcription to treat cancer and metabolic diseaseNils G ran Larsson Karolinska Institutet SwedenNot available on demand09 30 09 45G quadruplex binding protein Zuo1 is involved in telomere protection in S cerevisiae Mona Hajikazemi University Hospital Bonn GermanyNot available on demand09 45 10 00Regulation of ribosomal DNA repair by protein UFMylation Pudchalaluck Panichnantakul McGill University CanadaNot available on demand10 00 10 30The good the bad and the ugly SLX4IP dependent regulation of the Alternative Lengthening of Telomeres pathwayStephanie Panier Max Planck Institute for Biology of Aging GermanyNot available on demand10 30 11 00Coffee Break and Meet the Speakers11 00 11 30Aging of the genomeJan Vijg Albert Einstein College of Medicine USA11 30 11 45DNA damage induces nuclear envelope rupture through ATR mediated phosphorylation of Lamin Marton Kovacs Institut Curie France11 45 12 45Keynote lecture Telomere originated genomic instability at the origin of cancer and aging Maria Blasco Spanish National Cancer Research Center Spain Remote speaker 12 45 13 00Closing Remarks and Poster Prize13 00 13 30Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or 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Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

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BioMalPar XIX: biology and pathology of the malaria parasite

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Late registrations for onsite participation is possible Please contact Diah Yulianti to get the registration link Conference overview Malaria remains one of the most significant global public health challenges with more than 200 million clinical cases worldwide each year The lack of a vaccine that provides effective long term protection and the continual emergence of drug resistant malaria parasites emphasises the need for new control and prevention strategies This need for innovation has become even more apparent with the disruption of global malaria control programs due to the COVID 19 pandemic and potential reversal of gains made over the last few decades highlighted through a marked increase in malaria deaths in recent years The generation of fundamental knowledge lies at the heart of developing new tools and innovations for malaria intervention The malaria research community has a long history of being a highly collaborative field reliant on diverse technologies sharing of resources and dissemination of biological advances made Now more than ever it is important that we take advantage of the full diversity of the malaria scientific community to share the advances of cross disciplinary work that are vital for the translation of new ideas into public health impact BioMalPar XIX will showcase the multidisciplinary nature of malaria research with a programme that welcomes clinical malaria epidemiological studies immunology and evolution and ecology alongside core BioMalPar topics The programme focuses on early mid career researchers to help mitigate the effects of the COVID 19 pandemic which have been particularly acute for these stages Session topics Clinical and field studies Systems biology from molecules to cells physiology and pathobiology Evolution and ecology Immunology and vaccinology Transmission and vector parasite interactions New topics and tools for malaria research and future innovation What past participants say about the conference Just what I needed great speakers and I got a lot out of it If you are passionate about parasite biology this is one event you should not miss Special thanks to EMBL Advanced Training Centre Corporate Partnership Programme for providing financial assistance to attend the meeting Sunil Narwal CSIR Central Drug Research Institute Lucknow India Biomalpar 2021 was an excellent platform for a fresh PhD student like me to get exposure to various interesting research topics in malaria I am very happy and grateful to join and totally pumped with ideas after this year conference Thank you EMBL for this precious opportunity and see you again next year Tra Nguyen National University of Singapore Singapore Speakers Keynote speakers Sarah Auburn Menzies School of Health Research Australia Maria Bernabeu EMBL Barcelona Spain St phanie Blandin National Institute for Health and Medical Research Inserm and Institute of Molecular and Cell Biology France Aubrey Cunnington Imperial College London UK Elizabeth Egan Stanford University USA Melissa Kapulu University of Oxford and KEMRI Wellcome Trust UK Virtual speaker Geoff McFadden University of Melbourne Australia Jacquin Niles Massachusetts Institute of Technology USA Kamija Phiri University of Malawi Malawi Olivier Silvie National Institute for Health and Medical Research INSERM and Sorbonne University France Rita Tewari University of Nottingham UK Tuan Tran Indiana University School of Medicine USA Workshop trainers Sabrina Absalon Indiana University School of Medicine USA Hannah Bialic Wellcome Centre for Integrative Parasitology UK Mathieu Brochet University of Geneva Switzerland Julien Guizetti Heidelberg University Hospital Germany Franziska Hentzschel Heidelberg University Medical School Germany Thomas Otto University of Glasgow UK Scientific organiser Borko Amulic University of Bristol UK Michelle Boyle QIMR Berghofer Medical Research Institute Australia Emily Derbyshire Duke University USA Markus Ganter Heidelberg University Germany Emeritus steering group member Julian Rayner University of Cambridge UK Andy Waters University of Glasgow UK Conference organisers Diah Yulianti EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLMalaria Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk and the programme is subject to change For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 23 May 2023 Time Europe Berlin Speaker09 30 10 45Arrival Registration and refreshments10 45 11 00Opening remarks by scientific organisersScientific session 1 Evolution and ecologyChairs Tra Nguyen National University of Singapore SingaporeJes s Alvarado Valverde EMBL Heidelberg Germany11 00 11 30Drug resistance in malaria parasites inheritance of resistance genesGeoff McFadden University of Melbourne Australia11 30 11 45Insecticide resistance and vector competenceVictoria Ingham Heidelberg University Hospital Germany11 45 12 00Unpacking the EIP how mosquito resources affect parasite development and infectivity to vertebrate hosts Catherine Oke University of Edinburgh UK12 00 12 30Molecular surveillance of Plasmodium vivax new developments in the vivax Genomic Epidemiology NetworkSarah Auburn Menzies School of Health Research Australia12 30 12 45Widely varying switching rates of var genes in Plasmodium falciparum are evolutionary optimizedGayathri Iragavarapu IIIT H IndiaVIRTUAL TALK12 45 14 00Lunch and Meet the speakers virtual and onsite Scientific session 2 Clinical and field studiesChairs Giulia Siciliano Istituto Superiore di Sanit ItalyMayimuna Nalubega QIMR Berghofer Medical Research Institute Australia14 00 14 30Gift that keeps giving lessons learned about malaria from CHMI studiesMelissa Kapulu University of Oxford and KEMRI Wellcome Trust UKVIRTUAL TALK14 30 14 45Exploring neutrophils in cerebral malaria plasmodium falciparum in malawian children Watipenge Nyasulu Malawi Liverpool Welcome Clinical Research Programme UK14 45 15 00Recent increase in low complexity polygenomic infections and sialic acid independent invasion pathways in Plasmodium falciparum from Western Gambia Nora Nghochuzie Nganyewo Medical Research Council Unit The Gambia at London School of Hygiene and Tropical Medicine Gambia15 00 15 30Translational applications of the blood transcriptome in malariaAubrey Cunnington Imperial College London UK15 30 15 45Reversible host cell surface remodeling of Plasmodium falciparum gametocytes limits immune recognition and maximizes transmissionPriscilla Ngotho University of Glasgow UKVIRTUAL TALK15 45 16 15Coffee break and Meet the speakers 16 15 16 50Flash talks session 1Poster number 39 Dimuthu AngagePoster number 41 Shany AssarafPoster number 53 Casilda CastellanoPoster number 63 Bijayeeta DebPoster number 115 Francisco MartinezPoster number 137 Samuel PazickyPoster number 139 Joana SantosPoster number 147 Gala Ramon ZamoranoPoster number 169 Tatyana TavellaPoster number 171 Liana TheodoridisPoster number 183 Lasse Votborg Nov l16 50 18 50Poster session 1 odd numbers List of posters is available here 18 50 20 30Dinner EMBL canteen 20 30 22 00Science pub quiz optional 21 30 22 30Welcome drinks optional 20 30 21 30 22 30Buses downtown Day 2 Wednesday 24 May 2023 Time Europe Berlin SpeakerScientific session 3 Immunology and vaccinesChairs Anna Bachmann Bernhard Nocht Institute for Tropical Medicine GermanyVincent Geoghegan University of York USA09 00 09 30Severe malarial anaemia pathogenesis to preventionKamija Phiri University of Malawi Malawi09 30 09 45Structure of the malaria vaccine candidate Pfs48 45 and its recognition by transmission blocking antibodies Kuang Ting Ko University of Oxford UK 09 45 10 00Plasmodium falciparum exoerythrocytic forms require the PTEX translocon for development in human hepatocytes Robyn McConville Walter and Eliza Hall Institute Australia10 00 10 30Single cell multiomic characterization of peripheral immune cells in children who remain aparasitemic despite intensive exposure to Plasmodium falciparum malariaTuan M Tran Indiana University School of Medicine USANot available on demand live only10 30 11 00Coffee break11 00 11 45Lifetime achievement award Recipient Leann Tilley University of Melbourne Australia11 45 13 00Lunch and Meet the speakersScientific session 4 Transmission and vector parasite interactionsChairs Franziska Hentzschel Heidelberg University GermanySabrina Absalon Indiana University School of Medicine USA13 00 13 30Manipulating mosquito parasite interactions to decrease malaria transmissionStephanie Blandin National Institute for Health and Medical Research Inserm and Institute of Molecular and Cell Biology France13 30 13 45Investigating sporozoite development through the mosquito Ben Liffner Indiana University School of Medicine USA13 45 14 15Functional heterogeneity of microneme proteins in Plasmodium sporozoitesOlivier Silvie National Institute for Health and Medical Research INSERM and Sorbonne University France14 15 14 30A microtubule binding protein is critical for male gamete fertility in Plasmodium falciparumSudhir Kumar Seattle Children s Research Institute USAVIRTUAL TALK14 30 15 00Coffee break and Meet the speakers 15 00 15 35Flash talks session 2 Poster number 68 Melanie H DietrichPoster number 72 Nick DooleyPoster number 70 Giulia SicilianoPoster number 158 Mohini Anjna Shibu15 35 17 30Places are limited Registration required Available for onsite participants Workshop 1 Expansion microscopyTrainers Sabrina Absalon Indiana University School of Medicine USA Mathieu Brochet University of Geneva Switzerland Julien Guizetti Heidelberg University Hospital GermanyRoom Courtyard RoomPlease register here Workshop 2 Malaria single cell transcriptomics analysis Trainers Franziska Hentzschel Heidelberg University Medical School Germany Thomas Otto University of Glasgow UKRoom Flex LabsPlease register here Workshop 3 Public engagement Trainer Hannah Bialic Wellcome Centre for Integrative Parasitology UKRoom Helix Seminar Room APlease register here 17 30 19 30Poster session 2 even numbers List of posters is available here 19 30 20 45Dinner EMBL canteen 20 45 23 30Social event with live DJ drinks 21 00 22 00 00 00Buses downtown Day 3 Thursday 25 May 2023 Time Europe Berlin SpeakerScientific session 5 Systems biology of malaria molecules cells physiology and pathobiologyChairs Michaela Bulloch University of Melbourne AustraliaClinton Lau University of Oxford UK09 00 09 30Deciphering the role of the red cell in Plasmodium falciparum malariaElisabeth Egan Stanford University USA09 30 09 45Structure of the PfRCR complex which bridges the malaria parasite and erythrocyte during invasion Brendan Farrell University of Oxford UK09 45 10 00Exploring the role of uncoupled MCT1 basigin interaction and host membrane receptor context in Plasmodium falciparum merozoite invasion Tim Satchwell University of Bristol UK10 00 10 15Covalent probe reveals Ubc13 interactome in the malaria parasite Anna Truong Duke University USA10 15 10 45Coffee break and Meet the speakers 11 00 11 30Divide and Rule Unravelling atypical cell division in PlasmodiumRita Tewari University of Nottingham UK11 30 11 45A Plasmodium specific AP2 P regulates multiple pathogenicity factors with dual expression peaks during the intraerythrocytic developmental cycle Amit Kumar Subudhi King Abdullah University of Science and Technology Saudi Arabia11 45 12 00The Plasmodium falciparum artemisinin resistance protein Kelch 13 is required for formation of normal cytostomes and parasite feeding Stuart Ralph The University of Melbourne Australia12 00 13 15Lunch and Meet the speakers Scientific session 6 New topics and tools for malaria research and future innovationChairs Kodzo Atchou University of Bern SwitzerlandNick Dooley QIMR Berghofer Medical Research Institute Australia13 15 13 45Understanding cerebral malaria pathogenesis in a 3D blood brain barrier modelMaria Barnebeu EMBL Barcelona SpainNot available on demand live only13 45 14 00Culture adapted Plasmodium cynomolgi Berok transgenic parasites open up new avenues to accelerate drug discovery approaches for relapsing malaria Alexandra Probst Novartis Institute for Tropical Diseases USA14 00 14 15Aptamers targeting Plasmodium falciparum ESCRT III proteins as a potential antiplasmodial tool Yunuen Avalos Padilla Institute for Bioengineering of Catalonia Spain14 15 14 30Towards a multimodal 3D cell atlas of Plasmodium mosquito stages Nedal Darif EMBL Heidelberg Germany14 30 15 00A chemogenetics platform for antimalarial drug target identification and hit discoveryJacquin Niles Massachusetts Institute of Technology USA15 15 15 30Closing remarks by scientific organisers 16 00Buses departing Practical information Choosing onsite vs virtual participation You can choose to attend the conference either onsite in Heidelberg or virtually If you hope to present your research you need to decide which mode suits you best before the abstract submission deadline considering the below If you plan to attend the conference onsite you can register and apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline Please note that once you have registered for onsite attendance and submitted an abstract for an oral presentation you will still have the opportunity to present a poster onsite even if not selected for an onsite oral presentation However it is not possible to switch and apply for a virtual oral presentation after the submission deadline If you plan to attend the conference virtually you can only apply for a virtual oral presentation as there will be no virtual posters If your abstract is not selected for a virtual oral presentation you can still participate in the conference with access to all the live streamed talks a video library of the recorded talks and a facility to submit questions Only participants attending the event onsite can present a poster Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 710On site PhD Student 610On site Industry 910Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Raili Pall for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually Types of payments accepted are international bank transfers and credit card payments Abstract submission Both onsite and virtual participants are eligible to submit an abstract After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation for onsite participation and for oral presentation only for virtual participation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme in the form of both registration fee waivers and travel grants For the BioMalPar conference some additional Merck registration fee waivers are available These enable the attendance of doctoral students and post doctoral fellows from malaria endemic countries with the purpose of adding to the diversity of experiences represented by participants at the meeting Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the conference Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Travel grant The travel grant can be used to cover the cost of travel airfare train bus taxi accommodation visa and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants The financial assistance for onsite participation 7 December 2022 Please note that the deadline for applying for financial assistance for BioMalPar is earlier than the abstract submission deadline This is to allow successful applicants more time to apply for a travel visa to enter Germany if needed In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Your abstract will still be considered if you are not awarded financial help and you may still attend on a self funding basis if you wish Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Monday 24 April 2023 in some cases at special rates Please email the hotel directly quoting the booking code BMP23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel Here are the shuttle bus times for this conference View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual Participation Event platform We are using EMBL s event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners EMBO Molecular Medicine an EMBO Press journal International Union of Biochemistry and Molecular Biology Meet the MESA Correspondents that will cover the BioMalPar XIX Conference The MESA Correspondents are volunteers who report on the latest malaria research from conferences worldwide The synopses are shared online enabling people who could not attend the meeting to read about the research discussed The MESA Correspondents program is a collaboration between MESA and the conference organizers Faith Hungwe Aaron Lartey and Rinter Karimi will cover the sessions Summaries will be cross posted online on the MESA Correspondents page and MalariaWorld website Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

22 May - 26 May 2023

Expansion microscopy

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Expansion microscopy ExM physically magnifies specimens allowing to obtain super resolution images using a conventional diffraction limited microscope such as confocal microscopy This powerful technique is easy to implement but it requires some hands on training This workshop aims at disseminating and discussing expansion microscopy protocols and is intended for cell biologists parasitologists etc with applications ranging from tissue to cells Audience This course is intended for researchers ranging from PhD students to post docs and senior scientists as well as staff from bioimaging platforms who wish to establish expansion microscopy in their respective institutes Modules Resources Principles of expansion microscopy techniques U ExM Cryo ExM iU ExM Learning outcomes After this course you should be able to Apply expansion microscopy on your own samples once back in your laboratory sample preparation and imaging Spread the technique to your colleagues in their respective laboratories Choose the most appropriate expansion microscopy protocols for your needs Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Cali Anderson Proteintech Europe Ltd UK Ed Boyden Massachusetts Institute of Technology USA Virtual Speaker Lor ne Bournonville University of Geneva Switzerland Gautam Dey EMBL Heidelberg Germany Omaya Dudin Swiss Federal Institute of Technology Lausanne Switzerland Ruixuan Gao University of Illinois Chicago USA Virtual Speaker Paul Guichard University of Geneva Switzerland Sonia Gomes Pereira University of Geneva Switzerland Virginie Hamel University of Geneva Switzerland Lukas Kapitein Utrecht University The Netherlands Vincent Louvel University of Geneva Switzerland Rachel Mellwig EMBL Heidelberg Germany Felix Mikus EMBL Heidelberg Germany Markus Sauer Julius Maximilian University of W rzburg Germany Hiral Shah EMBL Heidelberg Germany Caroline Simon EMBL Heidelberg Germany Johanna Tocci EMBL Heidelberg Germany Joshua C Vaughan University of Washington USA Virtual Speaker Dietrich Walsh EMBL Heidelberg Germany Timo Zimmermann EMBL Heildeberg Germany Scientific Organizers Niccolo Banterle EMBL Heidelberg Germany Gautam Dey EMBL Heidelberg Germany Paul Guichard University of Geneva Switzerland Virginie Hamel University of Geneva Switzerland Marine Laporte University of Geneva Switzerland Course Organizers Maria Mercedes Bacadare Goitia Course and Conference Manager EMBL Heidelberg Germany Catherine Casas Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLExM Some pre course work such as watching pre recordings protocol reading and computational exercises will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change All times in the programme below are shown as the time in Europe Berlin Day 1 Monday 22 May 2023 Time Europe Berlin ProgrammeLocation08 15 08 45Bus departure from Premier Inn City Center Hotel to EMBL HeidelbergPremier Inn City Center Hotel bus stop08 45 09 30Arrival welcome and safety introductionsLecture Hall 10309 30 09 45Course overviewVirginie Hamel University of Geneva SwitzerlandLecture Hall 10309 45 10 45Lecture U ExM Cryo ExM iU ExMPaul Guichard University of Geneva SwitzerlandLecture Hall 10310 45 11 15Coffee breakLecture Hall 10311 15 12 45Participants Flash TalksLecture Hall 10312 45 13 30Lunch BreakCanteen13 30 15 00Workstations by groups13 30 14 15Workstation 1 Cryo fixation Group 1Lor ne Bournonville University of Geneva SwitzerlandOmaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandSonia Gomes Pereira University of Geneva SwitzerlandIC practical roomWorkstation 2 HPF Group 2Rachel Mellwig EMBL Heidelberg GermanyFelix Mikus EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg GermanyIC practical roomPractical lectures Expansion protocols Group 3 and Group 4Vincent Louvel University of Geneva SwitzerlandIC seminar rooms 2x 14 15 15 00Workstation 1 Cryo fixation Group 2Lor ne Bournonville University of Geneva SwitzerlandOmaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandSonia Gomes Pereira University of Geneva SwitzerlandIC practical roomWorkstation 2 HPF Group 1Rachel Mellwig EMBL Heidelberg GermanyFelix Mikus EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg GermanyIC practical roomPractical lectures Expansion protocols Group 3 and Group 4Vincent Louvel University of Geneva SwitzerlandIC seminar rooms 2x 15 00 15 45Lecture ExM for emerging and unconventional model systemsGautam Dey EMBL Heidelberg GermanyLecture Hall 10315 45 16 15Coffee BreakLecture Hall 10316 15 17 45Workstations by groups16 15 17 00Workstation 1 Cryo fixation Group 3Lor ne Bournonville University of Geneva SwitzerlandOmaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandSonia Gomes Pereira University of Geneva SwitzerlandIC practical roomWorkstation 2 HPF Group 4Rachel Mellwig EMBL Heidelberg GermanyFelix Mikus EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg GermanyIC practical roomPractical lectures Expansion protocols Group 1 and Group 2Vincent Louvel University of Geneva SwitzerlandIC seminar rooms 2x 17 00 17 45Workstation 1 Cryo fixation Group 4Lor ne Bournonville University of Geneva SwitzerlandOmaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandSonia Gomes Pereira University of Geneva SwitzerlandIC practical roomWorkstation 2 HPF Group 3Rachel Mellwig EMBL Heidelberg GermanyFelix Mikus EMBL Heidelberg GermanyCaroline Simon EMBL Heidelberg GermanyIC practical roomPractical lectures Expansion protocols Group 1 and Group 2Vincent Louvel University of Geneva SwitzerlandIC seminar rooms 2x 17 45 18 00Move samples to cell culture TLTraining Lab A B18 00 19 40Dinner and drinksCanteen19 40Bus departure to Premier Inn City Center HotelEMBL bus stop Day 2 Tuesday 23 May 2023 Time Europe Berlin ProgrammeLocation08 15 08 45Bus departure from Premier Inn City Center Hotel to EMBL HeidelbergPremier Inn City Center Hotel bus stop08 45 09 15Workstation Freeze substitution all groups HPF carrier processingTraining Lab A B09 15 10 00Project discussionFlex Lab A B10 00 10 45Workstation Sample rehydration all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A BWorkstation U ExM 10 unfixed and 10 cryo fixed and iU ExM coverslips prepared already by Vincent pre extraction one gel group STEP 1 all groups yeast U ExM Group 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B10 45 11 30Lecture Molecular Resolution Expansion MicroscopyMarkus Sauer Julius Maximilian University of W rzburg GermanyFlex Lab A B11 30 12 00Coffee breakFlex Lab A B12 00 12 45Virtual lecture A structurally homogeneous polymer for high isotropy expansion microscopyRuixuan Gao University of Illinois Chicago USAFlex Lab A B12 45 13 45Lunch breakCanteen13 45 15 00Workstation gelation chamber and U ExM and iU ExM first gelation chamber prepared by Vincent STEP 2 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A Bflexible coffee break15 00 15 30Workstation U ExM and iU ExM STEP 3 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg Germany15 30 16 30Project discussionFlex Lab A B16 30 17 00Coffee breakFlex Lab A B17 00 17 30Workstation U ExM and iU ExM STEP 4 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B17 30 18 15Virtual lecture Practical Overview of Expansion Microscopy and Simple Labeling StrategiesJoshua C Vaughan University of Washington USAFlex Lab A B18 15 19 45Tips Tricks with Pizza Dinner Rooftop lounge19 45Bus departure to Premier Inn City Center HotelEMBL bus stop Day 3 Wednesday 24 May 2023 Time Europe Berlin ProgrammeLocation08 15 08 45Bus departure from Premier Inn City Center Hotel to EMBL HeidelbergPremier Inn City Center Hotel bus stop09 00 10 00Workstation Immunostaining STEP 1 secondary WGA for iU ExM all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B10 00 10 45Lecture TREx and GelMap Tenfold expansion combined with intrinsic calibration and deformation mappingLukas Kapitein Utrecht University The NetherlandsIC Lecture Hall 10310 45 11 15Coffee breakIC Lecture Hall 10311 15 12 00Lecture Ichthyosporeans and the evolution of animal embryogenesisOmaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandIC Lecture Hall 10312 00 13 00Lunch breakCanteen13 00 13 45Workstation Immunostaining STEP 2 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B13 45 14 00Coffee breakIC Lecture Hall 10314 00 14 45Lecture Applications of U ExM from centriole architecture to retinopathiesVirgine Hamel University of Geneva SwitzerlandIC Lecture Hall 10314 45 15 45Sponsor talk 30min Zeiss IC tourImaging Centre15 45 16 00Sponsor talk 15 min Proteintech IC Lecture Hall 10316 00 17 15Workstation Immunostaining STEP 3 iU ExM washes all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B18 00 18 30Bus departure to downtownEMBL bus stop18 30 20 00Heidelberg Old Town tourNeckarm nzplatz20 00Downtown dinner Day 4 Thursday 25 May 2023 Time Europe Berlin ProgrammeLocation08 15 08 45Bus departure from Premier Inn City Center Hotel to EMBL HeidelbergPremier Inn City Center Hotel bus stop09 00 10 00Workstation iU ExM STEP 5 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B10 00 10 30Coffee breakFlex lab A B10 30 11 45Workstation iU ExM STEP 6 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B11 45 12 45Imaging session U ExM Widefield microscopes Group 1 and Group 2Group 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyZeiss Group 3Group 3 Hiral Shah EMBL Heidelberg GermanyNetworking and discussionGroup 4 organisers and speakersImaging Centre Microscopy rooms ATC IC seminar rooms12 45 13 45Lunch breakCanteen13 45 14 15Workstation iU ExM STEP 7 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B14 15 15 15Imaging session U ExM Widefield microscopes Group 3 and Group 4Group 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Caroline Simon EMBL Heidelberg GermanyZeiss Group 1Group 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandNetworking and discussionGroup 2 organisers and speakersImaging Centre Microscopy rooms ATC IC seminar rooms15 15 15 30Workstation iU ExM STEP 8 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B15 30 16 30Imaging session U ExM STED Group 2 and Group 3Group 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyZeiss Group 4Group 4 Caroline Simon EMBL Heidelberg GermanyNetworking and discussionGroup 1 organisers and speakersImaging Centre16 30 17 00Workstation iU ExM STEP 9 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B17 00 17 30Workstation iU ExM STEP 10 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B17 30 18 30Imaging session U ExM STED Group 1 and Group 4Group 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyZeiss Group 2Group 2 Johanna Tocci EMBL Heidelberg GermanyNetworking and discussionGroup 3 organisers and speakersImaging Centre18 30 19 30Workstation iU ExM STEP 11 all groupsGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyTraining Lab A B19 30 20 30DinnerCanteen20 30Bus departure to Premier Inn City Center HotelEMBL bus stop Day 5 Friday 26 May 2023 Time Europe Berlin ProgrammeLocation08 15 08 45Bus departure from Premier Inn City Center Hotel to EMBL HeidelbergPremier Inn City Center Hotel bus stop09 00 11 00Imaging session iU ExM all groups widefield and sted confocalGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyImaging Centre11 00 11 30flexible coffee breakCourtyard room A B11 30 13 00Imaging session iU ExM all groups widefield and sted confocalGroup 1 Lor ne Bournonville University of Geneva SwitzerlandGroup 1 Omaya Dudin Swiss Federal Institute of Technology Lausanne SwitzerlandGroup 2 Sonia Gomes Pereira University of Geneva SwitzerlandGroup 2 Johanna Tocci EMBL Heidelberg GermanyGroup 3 Felix Mikus EMBL Heidelberg GermanyGroup 3 Hiral Shah EMBL Heidelberg GermanyGroup 4 Vincent Louvel University of Geneva SwitzerlandGroup 4 Caroline Simon EMBL Heidelberg GermanyImaging Centre13 00 14 00Lunch breakCanteen14 00 15 00Course wrap upCourtyard room A B15 00 16 00Virtual keynote lecture Expansion Microscopy Development and ApplicationEd Boyden Massachusetts Institute of Technology USACourtyard room A B16 00 16 30Closing remarks and farewellCourtyard room A B16 30Bus departure to Heidelberg train station and city centerEMBL bus stop Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 675PhD Student 675Industry 1200 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights 21 26 May at the Premier Inn Heidelberg City Centre Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code EIC23 02 We recommend that all course participants stay at the Premier Inn City Center Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the Premier Inn Heidelberg City Centre Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partner Event sponsors Event supporters Media partners FocalPlane a The Company of Biologists microscopy community site Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 x 90...

Niccolo Banterle, Gautam Dey, Paul Guichard, Virginie Hamel, Marine Laporte

22 May - 26 May 2023

Microscopy data analysis: machine learning and the BioImage Archive

Description This virtual course will show how public bioimaging data resources centred around the BioImage Archive enable and enhance machine learning based image analysis The content will explore a variety of data types including electron and light microscopy and miscellaneous or multi modal imaging data at the cell and tissue scale Participants will cover contemporary biological image analysis with an emphasis on machine learning methods as well as how to access and use images from databases Further instruction will be offered using applications such as ZeroCostDL4Mic ilastik ImJoy the BioImage Model Zoo and CellProfiler Virtual course This course will be a virtual event delivered via a mixture of live streamed sessions pre recorded lectures and tutorials with live support We will be using Zoom to run the live sessions all fully password protected with automated English closed captioning and transcription with support and both scientific and social networking opportunities provided by Slack and other methods taking different time zones into account In order to make the most out of the course you should make sure to have a stable internet connection throughout the week and are available between 08 00 18 00 BST each day In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Selected participants may be sent materials prior to the course These might include pre recorded talks and required reading or online training that will be essential to fully engage with the course...

Shereen Pethania

21 May - 26 May 2023

Whole transcriptome data analysis

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview This course will teach the biological researchers how to analyse biological data sets using open source software Most of the analysis will be performed with docker4seq and rCASC packages which was developed to facilitate the use of computing demanding applications in the field of NGS data analysis Docker4seq and rCASC packages use docker containers that embed demanding computing tasks e g short reads mapping into isolated containers This approach provides multiple advantages the user does not need to install all the software on its local server the results generated by different containers can be organised in pipelines and reproducible research is guarantee by the possibility of sharing the docker images used for the analysis Computers for hands on exercises will be provided along with demo data sets Audience This course was developed for biological researchers as the intended audience Basic knowledge of massively parallel sequencing MPS is desirable however R coding skills and deep knowledge of statistics are not necessary Modules Resources Tools for RNA seq and single cell RNA seq data analysis Experimental design RNAseq scRNAseq Quality control RNAseq scRNAseq Normalisation and data reformatting RNAseq scRNAseq Basic statistics RNAseq Selecting differentially regulated genes microRNAs RNAseq Multiple testing RNAseq Dimensionality reduction scRNAseq Clustering RNAseq scRNAseq Biological interpretation RNAseq scRNAseq Learning outcomes Understand the importance of experimental design in order to ask sensible biological questions Assess the quality of your data Perform normalisation and reformatting procedures Complete basic statistical tests on Next Generation Sequencing NGS data Understand some of the problems encountered when analysing data What past participants say about this course My research focus is on RNA sequencing infectious diseases and next generation sequencing Attending this course helped me understand the basics got me career advice and extended my network Overall it made me a better researcher Abhay Deep Pandey Translational Health Science And Technology Institute India Excellent course on the complete spectrum of RNA Seq I would highly recommend this course to all biologists Issaac Rajan King Abdullah University of Science and Technology Saudi Arabia Speakers Speakers trainers and staff Marco Beccuti University of Turin Italy Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Maria L Ratto University of Turin Italy Scientific organisers Marco Beccuti University of Turin Italy Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Course organisers Inna B sselmann Course and Conference Manager EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it with EMBLDataAnalysis Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change All times in the programme below are shown as the time in Europe Berlin The preliminary programme is a draft and is subject to change Day 1 Sunday 21 May 2023 Time Berlin Europe SpeakerLocation13 30EMBL shuttle bus from ISG to EMBLISG Hotel entrance14 00 14 30Arrival welcome course overview and safety briefingVladimir Benes EMBL Heidelberg GermanyInna B sselmann EMBL Heidelberg GermanyIrena Provaznikova EMBL Heidelberg GermanyCourtyard Room A B14 30 15 00Participants flash talksCourtyard Room A B15 00 16 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard Room A B16 00 16 30Coffee BreakCourtyard Foyer16 30 18 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard Room A B18 00 19 00DinnerEMBL Canteen19 00EMBL shuttle bus to ISG HotelATC Entrance Day 2 Monday 22 May 2023 Time Berlin Europe SpeakerLocation08 40Embl shuttle bus from ISG to EMBLISG Hotel entrance09 00 10 00R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab10 00 10 30Coffee BreakATC Foyer10 30 11 00Experimental designRaffaele Calogero University of Turin ItalyComputer Training Lab11 00 12 00Docker4seq rCASC 4SeqGUI overviewRaffaele Calogero University of Turin ItalyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 13 30Docker container and reproducibilityMarco Beccuti University of Turin ItalyComputer Training Lab13 30 14 30QC bulkRaffaele Calogero University of Turin ItalyComputer Training Lab14 30 15 00Coffee BreakATC Foyer15 00 16 00QC single cellsRaffaele Calogero University of Turin ItalyComputer Training Lab16 00 17 30R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab17 30 18 30Social programme Facility tour18 30 20 10DinnerEMBL Canteen20 15EMBL shuttle bus to ISG HotelATC Entrance Day 3 Tuesday 23 May 2023 Time Berlin Europe SpeakerLocation08 40EMBL shuttle bus from ISG to EMBLISG Hotel entrance09 00 10 30R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab10 30 11 00Coffee BreakATC Foyer11 00 12 30Counting reads and data reductionRaffaele Calogero University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 00Counting reads and data reductionRaffaele Calogero University of Turin ItalyComputer Training Lab15 00 16 00Counting reads miRNAFrancesca Cordero University of Turin ItalyComputer Training Lab16 00 16 30Coffee BreakATC Foyer16 30 18 00ExercisesComputer Training Lab18 00 19 00R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab19 00 20 30DinnerEMBL Canteen20 30EMBL shuttle bus to ISG HotelATC Entrance Day 4 Wednesday 24 May 2023 Time Berlin Europe SpeakerLocation08 40Hoffmann Bus from ISG to EMBLISG Hotel entrance09 00 10 00Differential expression analysis for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab10 00 11 00Sub population discovery in single cell RNAseq clusteringRaffaele Calogero University of Turin ItalyComputer Training Lab11 00 11 30Coffee BreakATC Foyer11 30 12 30Differential expression analysis for multiple groups ANOVA likeRaffaele Calogero University of TurinComputer Training Lab12 30 13 30Lunch and group photoEMBL Canteen13 30 15 00Exercises Bulk RNAseqComputer Training Lab15 00 16 00Exercises single cell RNAseqComputer Training Lab16 00 16 30Coffee BreakATC Foyer16 30 18 00R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab18 00EMBL shuttle bus to restaurantATC Entrance19 00Social Dinner at Oskar Restaurant Day 5 Thursday 25 May 2023 Time Berlin Europe SpeakerLocation08 40Hoffmann Bus from ISG to EMBLISG Hotel entrance09 00 10 00R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab10 00 11 00Mining differential expression results for bulk RNAseqRaffaele Calogero University of Turin ItalyComputer Training Lab11 00 11 30Coffee BreakATC Foyer11 30 12 30Depicting clusters specific biomarkers in single cell RNAseq dataFrancesca Cordero University of Turin ItalyComputer Training Lab12 30 13 30Lunch EMBL Canteen13 30 16 00ExercisesComputer Training Lab16 00 16 30Coffee BreakATC Foyer16 30 17 30ExercisesComputer Training Lab17 30 18 30R pills theory and practiceMarco Beccuti University of Turin ItalyComputer Training Lab18 30 20 00DinnerEMBL Canteen20 00EMBL shuttle bus to ISG HotelATC Entrance Day 6 Friday 26 May 2023 Time Berlin Europe SpeakerLocation08 40EMBL shuttle bus from ISG to EMBLISG Hotel entrance09 00 11 00 Individual exercises on bulk or single cell RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab11 00 11 30Coffee BreakATC Foyer11 30 12 30Individual exercises on bulk or single cell RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Individual exercises on bulk or single cell RNAseqRaffaele Calogero University of Turin ItalyMarco Beccuti University of Turin ItalyComputer Training Lab16 00 16 20Final remarksVladimir Benes Raffaele Calogero Marco BeccutiComputer Training Lab16 30Hoffmann shuttle bus to Heidelberg Train StationATC Entrance Practical information Registration fees and motivation letter The course is limited to 28 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration Fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 690PhD Student 690Industry 1200 Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For more detailed information follow the instructions provided in our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Single rooms have been reserved for 6 nights 20 26 May 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code DAT23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course All software and hardware required for this course will be ready for you to use in our Computer Training Lab You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional Information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Marco Beccuti, Vladimir Benes, Raffaele Calogero, Francesca Cordero

18 May - 19 May 2023

EMBL in Italy 2023: Chance and necessity-the indispensable role of curiosity-driven life sciences

Description If you are not redirected please visit the event website...

17 May 2023

Annotating genomes with non-coding RNAs using Rfam and Infernal

Description Rfam is a database of RNA families that currently contains over 4 000 families Together with the Infernal software Rfam is commonly used to annotate non coding RNAs in newly sequenced genomes In this webinar we will give an overview of the data available in Rfam and give a live demo of annotating a genome with non coding RNAs using Rfam and the Infernal software We will also discuss recent efforts to synchronise Rfam and miRBase...

16 May - 18 May 2023

Practical biocuration

Description This three day course will introduce concepts vital to biocuration including metadata and ontologies the role of identifiers and extracting data from literature During the course there will be a focus on practical skills required by biocurators including programming for handling large biological datasets and querying databases Participants will have the opportunity to use these skills in a real life practical biocuration exercise during the group projects There will also be an opportunity to network with biocurators and learn more about their roles and data resources Group projects A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI and external institutes This allows people to explore the role of biocurators and provide participants with hands on experience in biocuration The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion in the whole course group Groups are mentored and supported by the trainers who set the initial challenge but the groups will be responsible for driving their projects forward with all members expected to take an active role Groups are pre organised before the course Basic outlines of the projects on offer this year are given below In your registration you must indicate your first and second choice of project Not all projects may be offered and final decisions on which projects will be run during the course will be made based on the number of applicants per project Group project Curating a protein complex In this project a new protein complex has been published and it is your role to find out as much information as possible about the complex Using literature and bioinformatics resources you will provide an overview of the protein complex including a full list of the complex members a description of the role of each protein and an overview of the role of the complex You will use resources such as UniProt PDB and EuropePMC Project mentor Michele Magrane Group project Exploring data and metadata from a genome wide association study The GWAS Catalog is a richly annotated database of human genome wide association studies which analyse associations between genetic variants and a disease or other trait of interest in a sample of individuals from a particular population In this mini project you will examine a GWAS publication in detail to extract information about the traits and samples under investigation and decide how to represent these metadata using standardised vocabularies and ontologies You will also use simple command line tools to look at a GWAS dataset and explore the role of standard formats and quality control in biocuration Project mentor Elliot Sollis Group project Using alignments to improve Rfam families a case of curating non coding RNA families Rfam is the database of non coding RNAs ncRNAs families These families are built out of a sequence alignment metadata describing the family and an infernal model Each family is built by curating alignments from publications or user submitted alignments In this project we will demonstrate the process of updating an existing family with an improved alignment We will examine the reports generated during curation In this process we will examine the phylogenetic distribution sequence alignment and model results to determine how the family should be updated to reflect the improved alignment Additionally we will show how to connect this information to resources like Wikipedia Project mentor Nancy Ontiveros...

Sophie Spencer

15 May - 18 May 2023

Chromatin and epigenetics

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPre conference workshop Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Conference overview Epigenetics refers to heritable changes in gene expression that do not involve changes to the underlying DNA sequence At least three systems including DNA methylation histone modifications and non coding RNAs ncRNA are considered to play fundamental roles in epigenetic regulation Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases Moreover influence of age environment lifestyle and disease state on epigenetic states is being increasingly appreciated and actively studied This conference provides an international forum for cutting edge research in chromatin and epigenetics It provides the focal hub for people to present their research and exchange ideas Renowned speakers will cover the latest advances in the field Session topics Heterochromatin Developmental epigenetics Chromatin regulation Transcription and chromatin defects and diseases Nuclear architecture Single cell genomics What past participants say about the conference The conference was very thoughtfully organised and the subject matter allowed me to deepen my knowledge on many interesting levels It was a valuable experience that I would like to repeat in the future Magdalena University of Lodz Poland The training provided by EMBL was very fruitful and productive I would like to be a part of such training in future too and also like to recommend others to be part of it Dr Laxman Khanal BPKIHS Nepal Although online this conference was well organised with an overall great quality of talks about many novelties If I can I will definitely attend the next time maybe already on site Tobias Hohl Max Planck Institute of Immunology and Epigenetics Germany Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote Speaker Genevi ve Almouzni Institut Curie France Speakers Asifa Akhtar Max Planck Institute of Immunobiology and Epigenetics Germany Robin Allshire The University of Edinburgh UK Yehudit Bergman The Hebrew University of Jerusalem Israel Wendy Bickmore The University of Edinburgh UK Marc B hler Friedrich Miescher Institute for Biomedical Research Switzerland L Stirling Churchman Harvard Medical School USA Ibrahim Ciss Max Planck Institute of Immunobiology and Epigenetics Germany Rong Fan Yale University USA Mary Gehring Whitehead Institute for Biomedical Research USA Steven Henikoff Fred Hutchinson Cancer Research Center USA Nicola Iovino Max Planck Institute of Immunobiology and Epigenetics Germany Gary H Karpen University of California Berkeley USA Haruhiko Koseki RIKEN Japan Cornelis Murre University of California San Diego USA Paola Scaffidi Francis Crick Institute UK Anne Sch fer Max Planck Institute for Biology of Ageing Germany Efrat Shema Weizmann Institute of Science Israel Yang Shi Ludwig Cancer Research UK Alexander Stark Research Institute of Molecular Pathology Austria Sarah Teichmann Wellcome Sanger Institute UK Yi Zhang Howard Hughes Medical Institute Harvard Medical School and Boston Children s Hospital USA Scientific organisers Asifa Akhtar Max Planck Institute of Immunobiology and Epigenetics Germany Yehudit Bergman The Hebrew University of Jerusalem Israel Nicola Iovino Max Planck Institute of Immunobiology and Epigenetics Germany Gary H Karpen University of California Berkeley USA Sarah Teichmann Wellcome Sanger Institute UK Conference organiser Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLChromatin Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Monday 15th May 2023 Time Berlin Europe SpeakerLocation12 30 14 30Arrival and RegistrationATC Registration Desk13 00 14 00Pre conference workshop Single molecule biology democratizing optical tweezers to enable your breakthrough discoveries in chromatin biology and epigenetics by LUMICKS B V registration required Courtyard room14 30 16 50Session 1 Chromatin RegulationChairs Yang Shi and Wendy Bickmore14 30 14 45Opening remarksNicola Iovino Max Planck Institute of Immunobiology and Epigenetics GermanyKlaus Tschira Auditorium14 45 15 10Genome wide mapping of chromatin dynamicsSteven Henifkoff Fred Hutchinson Cancer Research Center USAKlaus Tschira Auditorium15 10 15 25Repair of double strand breaks in Drosophila polycomb bodiesAniek Janssen University Medical Center Utrecht The NetherlandsKlaus Tschira Auditorium15 25 15 40A regulator of RNA Polymerase III embedded in the tDNA chromatin proteomeFred van Leeuwen Netherlands Cancer Institute The NetherlandsKlaus Tschira Auditorium15 40 16 05Epigenetic dynamics during plant reproductionMary Gehring Whitehead Institute for Biomedical Research USAKlaus Tschira Auditorium16 05 16 50Coffee Break Meet the Speakers of Day 1Steven Henikoff Mary Gehring Gary Karpen Robin Allshire Marc B hlerAuditorium Foyer16 50 19 05Session 2 HeterochromatinChairs Yehudit Bergman and Alexander Stark16 50 17 15New insights into formation organization and function of heterochromatin condensatesGary Karpen University of California Berkeley USAKlaus Tschira Auditorium17 15 17 30Coordination of chromatin functions and genome stability by the nuclear membrane protein Lem2Sigurd Braun Justus Liebig Universit t Gie en GermanyKlaus Tschira Auditorium17 30 17 45The bromodomain inhibitor JQ1 is a molecular glue targeting BRD4 to centromeric chromatinSamuel Corless Karlsruhe Institute of Technology KIT GermanyKlaus Tschira Auditorium17 45 18 10Epigenetic Regulation Heterochromatin and Antifungal ResistanceRobin Allshire University of Edinburgh UKNot available on demandKlaus Tschira Auditorium18 10 18 25VIRTUALLinker histone H1 differentially impacts the Polycomb chromatin landscape at genes and telomeric repeats in ArabidopsisFredy Barneche Ecole Normale Sup rieure France remote speaker Klaus Tschira Auditorium18 25 18 40DiMeLo seq mapping protein DNA interactions and DNA modifications on single chromatin fibers using long read sequencingNicolas Altemose Stanford University USAKlaus Tschira Auditorium18 40 19 05The ChAHP complexesMarc B hler Friedrich Miescher Institute for Biomedical Research SwitzerlandNot available on demandKlaus Tschira Auditorium19 05 20 30DinnerEMBL Canteen20 30 22 00Drinks and poster previewATC Foyer and Helix A B Day 2 Tuesday 16th May 2023 Time Berlin Europe SpeakerLocation8 30 9 00Coffee and light refreshmentsAuditorium Foyer9 00 12 30Session 3 Developmental epigeneticsChairs Gary Karpen and Raffaella Santoro9 00 9 25Epigenetic regulation by the MSLs old complex new factsAsifa Akhtar Max Planck Institute of Immunobiology and Epigenetics GermanyNot available on demandKlaus Tschira Auditorium9 25 9 50Mechanism and function of PRC1 and PRC2 in mouse gastrulationYi Zhang Howard Hughes Medical Institute Harvard Medical School and Boston Children s Hospital USANot available on demandKlaus Tschira Auditorium9 50 10 05The Tbx factor Eomes instructs global chromatin dynamics during pluripotency exit to initiate first lineage specificationSebastian Arnold University of Freiburg GermanyKlaus Tschira Auditorium10 05 10 20Signal decoding at the Xist locusEdda Schulz Max Planck Institute for Molecular Genetics GermanyKlaus Tschira Auditorium10 20 11 05Coffee Break Meet the Speakers of Day 2Asifa Akhtar Yi Zhang Nicola Iovino Rong Fan Yehudit Bergman Ibrahim Ciss Efrat ShemaAuditorium Foyer11 05 11 30Epigenetics of early developmentNicola Iovino Max Planck Institute of Immunobiology and Epigenetics GermanyNot available on demandKlaus Tschira Auditorium11 30 11 45Molecular timetable of differentiation in human pluripotent stem cellsMaria Rostovskaya Babraham Institute UKKlaus Tschira Auditorium11 45 12 00Uncovering how the genome directs development mother to daughter cell regulation of chromatin and gene expression in C elegans embryogenesisJulie Ahringer University of Cambridge UKKlaus Tschira Auditorium12 00 12 15Soma to germline small RNA transfer promotes intragenerational survival to environmental stressGermano Cecere Institut Pasteur FranceKlaus Tschira Auditorium12 15 12 30RNA pol I shapes the large scale chromatin architecture in response to nutrients in C elegansDaphne Cabianca Helmholtz Zentrum Munich GermanyNot available on demandKlaus Tschira Auditorium12 30 14 30Lunch Auditorium Foyer13 30 15 30Poster Session I odd numbers Helix A B15 30 18 25Session 4 Single cell genomics and microscopyChairs Asifa Akhtar and Cornelis Murre15 30 15 55Epigenetic programming of allelic extinctionYehudit Bergman Hebrew University of Jerusalem IsraelKlaus Tschira Auditorium15 55 16 10Genome wide profiling of DNA repair detects higher order coordination in single cellsJop Kind Hubrecht Institute The NetherlandsKlaus Tschira Auditorium16 10 16 40Coffee Break Meet the EditorsTiago Faial Linda Koch Sara Osman Sabrya Carim Lavinia Arseni Vitor SousaAuditorium Foyer16 40 17 05Spatial Epigenome Sequencing of Mouse and Human BrainRong Fan Yale University USAKlaus Tschira Auditorium17 05 17 30Single molecule and single cell epigenetics Decoding the epigenome for cancer research and diagnosticsEfrat Shema Weizmann Institute of Science IsraelKlaus Tschira Auditorium17 30 17 55Super resolution imaging of transcription in living cellsIbrahim Ciss Max Planck Institute of Immunobiology and Epigenetics GermanyKlaus Tschira Auditorium17 55 18 10TET activity propagates cellular memory through embryonic dormancyAydan Bulut Karslioglu Max Planck Institute for Molecular Genetics GermanyKlaus Tschira Auditorium18 10 18 25The Drosophila acetyltransferase chameau chm promotes starvation resilience at the expense of a shortened life spanAxel Imhof Ludwig Maximilians University of Munich GermanyKlaus Tschira Auditorium18 25 20 00DinnerEMBL Canteen20 00 22 00Pub quiz with after dinner drinksEMBL Canteen Day 3 Wednesday 17th May 2023 Time Berlin Europe SpeakerLocation8 30 9 00Coffee and light refreshmentsAuditorium Foyer9 00 17 25Session 5 Transcription and chromatin and diseasesMorning Chairs L Stirling Churchman and Robin AllshireAfternoon Chairs Steven Henifkoff and Julie Ahringer9 00 9 25Chromatin regulation in immuno oncologyYang Shi Ludwig Cancer Research UKNot available on demandKlaus Tschira Auditorium9 25 9 40Transcription restart stimulates chromatin reassembly following DNA replicationConstance Alabert University of Dundee UKKlaus Tschira Auditorium9 40 9 55Nucleosomal Asymmetry Regulates Reader Recruitment and Poising at Bivalent DomainsPhilipp Voigt Babraham Institute UKKlaus Tschira Auditorium9 55 10 20Decoding regulatory networks in human development one cell at a timeSarah Teichmann Wellcome Sanger Institute UKKlaus Tschira Auditorium10 20 11 05Coffee Break Meet the Speakers of Day 3Yang Shi Paola Scaffidi L Stirling Churchman Sarah TeichmannAuditorium Foyer11 05 11 30Epigenetic dysregulation and cancer evolutionPaola Scaffidi Francis Crick Institute UKKlaus Tschira Auditorium11 30 11 45Intrinsic transcription factor cooperativity in reconstituted na ve embryonic chromatinPeter B Becker Ludwig Maximilians University of Munich GermanyKlaus Tschira Auditorium11 45 12 00H4K16ac activates the transcription of transposable elements and contributes to their cis regulatory functionPradeepa Madapura Queen Mary University of London UKKlaus Tschira Auditorium12 00 14 00LunchAuditorium Foyer13 00 15 00Poster Session II even numbers Helix A B15 00 15 25RNA Polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiationL Stirling Churchman Harvard Medical School USANot available on demandKlaus Tschira Auditorium15 25 15 40An RNA dependent and phase separated active subnuclear compartment safeguards repressive chromatin domainsRaffaella Santoro University of Zurich SwitzerlandKlaus Tschira Auditorium15 40 15 55Chromatin ubiquitylation in development and diseasePeter Verrijzer Erasmus University Medical Center The NetherlandsKlaus Tschira Auditorium15 55 16 20Epigenetic mechanisms of microglia driven neurodegenerationAnne Sch fer Max Planck Institute for Biology of Ageing Germany remote speaker Klaus Tschira Auditorium16 20 16 35Chem map profiles drug binding to chromatin in cellsZutao Yu University of Cambridge UKKlaus Tschira Auditorium16 35 16 50The Sex specific Factor SOA Establishes X Chromosome Dosage Compensation in Anopheles MosquitosClaudia Keller Valsecchi Institute of Molecular Biology IMB Mainz GermanyKlaus Tschira Auditorium16 50 17 00Poster Prize AnnouncementsKlaus Tschira Auditorium17 00 17 20Coffee BreakAuditorium FoyerFree evening Day 4 Thursday 18th May 2023 Time Berlin Europe SpeakerLocation8 30 9 00Coffee and light refreshmentsAuditorium Foyer9 00 16 40Session 6 Nuclear architectureMorning Chairs Ibrahim Ciss and Paola ScaffidiAfternoon Chairs Nicola Iovino and Yi Zhang9 00 9 25Enhancer promoter contacts depends how you look at itWendy Bickmore The University of Edinburgh UKKlaus Tschira Auditorium9 25 9 40Chromosome scale organization of the regulatory genome in the Drosophila nervous systemMaria Cristina Gambetta University of Lausanne SwitzerlandNot available on demandKlaus Tschira Auditorium9 40 9 55In vitro reconstitution of chromatin domainsMarieke Oudelaar Max Planck Institute for Multidisciplinary Sciences GermanyKlaus Tschira Auditorium9 55 10 20Decoding transcriptional regulationAlexander Stark Research Institute of Molecular Pathology AustriaNot available on demandKlaus Tschira Auditorium10 20 11 05Coffee Break Meet the Speakers of Day 4Wendy Bickmore Alexander Stark Cornelis Murre Haruhiko Koseki Genevieve AlmouzniAuditorium Foyer11 05 11 20Structural basis of H3K36 trimethylation by SETD2 during chromatin transcriptionLucas Farnung Harvard Medical School USAKlaus Tschira Auditorium11 20 11 35Recycling of modified H2A H2B provides short term memory of chromatin statesValentin Flury University of Copenhagen DenmarkKlaus Tschira Auditorium11 35 11 50Poster Prize Short talk 1 Alternative splicing decouples local from global PRC2 activityNiccol Arecco Centre for Genomic Regulation CRG Spain Klaus Tschira Auditorium11 50 12 05Poster Prize Short talk 2 Histone divergence in Trypanosoma brucei results in uniquealterations in nucleosome structureGauri Deak University of Edinburgh UK Klaus Tschira Auditorium12 05 13 35LunchCanteen13 35 14 00Molecular Mechanisms that Instruct Nuclear ShapeCornelis Murre University of California San Diego USANot available on demandKlaus Tschira Auditorium14 00 14 15DNA elements tether Polycomb Repressive Complex 1 to translate histone methylation into chromatin foldingYuri Schwartz Ume University SwedenKlaus Tschira Auditorium14 15 14 30Genome access is transcription factor specific and defined by nucleosome positionRalph Grand Center for Molecular Biology of Heidelberg University ZMBH DKFZ ZMBH Alliance GermanyKlaus Tschira Auditorium14 30 14 55SKP1A links Polycomb repressed genes with proteasomeHaruhiko Koseki RIKEN JapanKlaus Tschira Auditorium14 55 15 25Coffee BreakAuditorium Foyer15 25 15 40Nucleosome sliding in condensed chromatinFelix Mueller Planitz Institute for physiological chemistry TU Dresden GermanyKlaus Tschira Auditorium15 40 15 55Chromosome structure regulated by a transcription dependent RNA polymer gelNick Gilbert The University of Edinburgh UKKlaus Tschira Auditorium15 55 16 40Histones variants and friends a state of play for shaping chromatin and cell fateKeynote speaker Genevi ve Almouzni Institut Curie FranceNot available on demandKlaus Tschira Auditorium16 40 17 00Closing remarksKlaus Tschira Auditorium17 00 18 00Ap ritifATC Foyer18 00 20 30Conference DinnerEMBL Canteen20 30 00 00Conference Party Live DJ and drinksAuditorium Foyer Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks live streamed and on demand and the facility to submit questions On site Academia 775On site PhD Student 675On site Industry 975Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Charlotte Courtney for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 14th April 2023 in some cases at special rates Please email the hotel directly quoting the booking code CHR23 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel Staycity Aparthotels Here are the shuttle bus times for EMBL Conference Chromatin and epigenetics View Conference shuttle bus stops and hotels on a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless 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in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Silver sponsor Bronze sponsors Event sponsor Arima Genomics Cell Research New England Biolabs GmbH Media partners Development a The Company of Biologists journal EMBO reports an EMBO Press journal International Union of Biochemistry and Molecular Biology FEBS Letters a FEBS Press journal FEBS Open Bio a FEBS Press journal FEBS Journal a FEBS Press journal Open Biology a Royal Society journal Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Nature a Nature Portfolio journal Nature Genetics a Nature Portfolio journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90 Pre conference workshop Pre conference workshop For on site participants only This industry webinar will be hosted by our sponsor LUMICKS B V prior to the EMBL Conference Chromatin and Epigenetics on Monday 15 May 2023 13 00 14 00 Participation in this workshop is free of charge for registered on site conference attendees The number of available places is limited first come first served All registered conference attendees will receive an email with a registration link towards the end of April ABSTRACT Single molecule biology democratizing optical tweezers to enable your breakthrough discoveries in chromatin biology and epigenetics Roman Renger Emma Verver Philipp RauchLUMICKS B V Amsterdam The Netherlands The structure regulation maintenance and organization of chromatin is critical to cellular function Errors in the underlying molecular mechanisms play a major role in diseases such as cancer Hence insights into the molecular details are needed to advance our understanding improve biological models and develop novel therapeutics Dynamic single molecule technologies offer an exciting opportunity to meet these challenges and to study protein dynamics function and activity in real time In this workshop we present our efforts for enabling discoveries in the field of chromatin and epigenetics research With the C Trap we provide an easy to use instrument that combines optical tweezers fluorescence microscopy and microfluidics It allows to visualize the interaction and activity of individual protein complexes with and on chromatin in real time assemble chromatin structures in situ and to directly measure the mechanical forces that determine chromatin architecture We will cover several example studies in which our technology biochemistry and data analysis solutions enhanced the understanding of chromatin biology ranging from DNA damage repair to CRISPR Cas based gene editing to nucleosome remodeling and even the mechanical properties of individual chromatin fibers to complete chromosomes...

Asifa Akhtar, Yehudit Bergman, Nicola Iovino, Gary Karpen, Sarah Teichmann

10 May 2023

Developing an improved understanding of the structure and function of the wheat root microbiome

Description The root microbiome is selected by plants and can benefit crop plants in several ways including improved plant nutritional status as well as protection against biotic and abiotic stresses There are various factors which determine the wheat root microbiome community structure and developing a robust understanding of these is imperative for the development of sustainable agricultural systems This webinar explores the relative importance of factors such as fertilisation regime land management and plant genotype in shaping the structure and function of the wheat root microbiome and how this knowledge can be taken forward to develop microbiome facilitated agriculture...

Tim Mauchline

10 May 2023

Data protection and privacy preservation in software development

Description When writing software to process health genetic or other sensitive data in High Performance Computing HPC clusters software developers and researchers must consider the requirements of the General Data Protection Regulation including the principle of privacy by design and the duties of data protection In this webinar we will highlight the risks of working with sensitive data on an HPC cluster and what are common software vulnerabilities We will discuss general best practices in software development and provide guidelines on how to handle data in applications We will also raise awareness of outside factors that affect data security and briefly mention important generic organisational measures that should be in place About the speaker Sarah Peter studied Bioinformatics and worked for a few years as a researcher and data manager at the Max Planck Institute Now she works at the Luxembourg Centre for Systems Biomedicine UNILU as an Infrastructure Engineer in the R3 and IT Infrastructure team She is also the liaison for the HPC team Since GDPR has come into effect she spends some of her time doing risk analysis for the institute s IT infrastructure and the HPC cluster...

9 May - 12 May 2023

The organism and its environment

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview We are at the dawn of a new era of biology where we will start to understand how organisms function together and react or adapt to changes at different molecular levels This includes the multitude of stressors that organisms are exposed to from malnutrition and adverse climate events to many other biological chemical and physical insults Progress in biological analyses at both a single scale and across scales have allowed us to further understand organisms in the context of dynamic environments These can be environments which are changed by disease commensal cohabitation or competition as well as abiotic factors With the molecular understanding we already have at the cellular and organismal levels and new tools and quantitative approaches this symposium will address how genotype and the environment bring about phenotypes at the population level Topics Biodiversity Marine symbiosis Terrestrial Symbiosis Theory of organismal interactions Enviromental adptation in model organisims Paleogenomics What past participants say about the symposium An excellent meeting covering important topics for future research with outstanding speakers and excellent enthusiastic students Isabel Gordo Instituto Gulbenkian de Ci ncia Portugal I really enjoyed the quality and diversity of the talks all related but different Enriching and awesomely organized conference Julie Zaworski New England Biolabs USA One of the most enriching conferences in the recent past Great venue great food great support team and outstanding speakers and presentations Kudos to the AV team for the glitch free remote presentations A great platform for young researchers and emerging scientists Anupam Sengupta University of Luxembourg Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Keynote speaker Richard Durbin University of Cambridge UK Speakers Yasmine Belkaid National Institutes of Health USA Virtual speaker Silvia Bulgheresi University of Vienna Austria Maria Dzunkova University of Valencia Spain Kate Farquharson University of Sydney Australia Aissam Ikmi EMBL Heidelberg Germany Martin Kaltenpoth Max Planck Institute for Chemical Ecology Germany Jos Maria Montoya Teran CNRS France Raquel Peixoto King Abdullah University Saudi Arabia Virtual speaker Emma Rocke University of Cape Town South Africa Wenying Shou University College London United Kingdom Raffaele Siano IFREMER France Sk li Sk lason H lar University and the Icelandic Museum of Natural History Iceland Ricard Sol Catalan Institute for research and Advanced Studies Spain Flora Vincent EMBL Heidelberg Germany Detlef Weigel Max Planck Institute for Biology T bingen Germany Phillip Wilcox University of Otago New Zealand Anna Zaidman Remy INSA Lyon France Virtual speaker Scientific organisers Detlev Arendt EMBL Heidelberg Germany Edith Heard EMBL Heidelberg Germany Maria Leptin European Research Council Belgium Fiona Watt EMBO Germany Detlef Weigel Max Planck Institute for Biology T bingen Germany Conference organiser Maria Mercedes Bacadare Goitia EMBL Heidelberg Germany Programme Got something to say Tweet it EESOrganism For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Tuesday 9 May 2023 Time Europe Berlin Speaker14 00 15 00Registration and light refreshments15 00 15 15Opening remarks15 15 18 30Session 1 BiodiversityChair Tobias Gerber EMBL Heidelberg Germany15 15 15 45In what way does the organism environment association drive the development and evolution of biological diversity Sk li Sk lason H lar University College Iceland15 45 16 00A Diatoms tale from the sea to lab and back Antonella Ruggiero EMBL Stazione Zoologica A Dohrn Germany16 00 16 15Evolution of canalization lessons from a classic case of resource polymorphismKalina Kapralova University of Iceland Iceland16 15 17 00Coffee break17 00 17 30Australian genomes saving us and saving themKate Farquharson The University of Sydney Australia17 30 17 45Functional analysis of dna methylation in the marbled crayfish as a model to study rapid adaptation and invasivenessJaime Diaz Larrosa German Cancer Research Center DKFZ Germany17 45 18 00Targeted volume Correlative Light and Electron Microscopy of an environmental marine microorganismKarel Mocaer EMBL Heidelberg GermanyNot available on demand18 00 18 30Plant ParanoiaDetlef Weigel Max Planck Institute for Biology T bingen Germany18 30 19 30Dinner in Canteen19 30 20 30Drinks in ATC Rooftop lounge Day 2 Wednesday 10 May 2023 Time Europe Berlin Speaker09 30 12 00Session 2 Marine symbiosisChair Antonella Ruggiero EMBL Heidelberg Germany Stazione Zoologica Anton Dohrn Italy09 30 10 00Microbial communities driving nutrient and carbon cycling in the Southern Benguela upwelling regionEmma Rocke University of Cape Town South Africa10 00 10 15Interactions between marine picocyanobacteria and particulate chitinGiovanna Capovilla Massachusetts Institute of Technology MIT United States of America10 15 10 30The genetic mechanisms underlying the transition to piscivoryMarina de la C mara University of Iceland Iceland10 30 11 00Coffee break11 00 11 30Synthase selected single cell genomics for discovering symbiotic microbes providing chemical defense for soft bodied marine animalsMaria Dzunkova Univeristy of Valencia Spain11 30 11 45Bacterial physiology in an environmental ContextEinat Segev Weizmann Institute of Science Israel11 45 12 00Nitric oxide signaling controls collective contractions in a colonial choanoflagellateJosean Reyes Rivera University of California Berkeley Howard Hughes Medical Institute United States of AmericaNot available on demand12 00 13 00Lunch13 00 17 00Session 2 Marine symbiosis cont Chair Detleft Weigel Max Planck Institute for Biology T bingen Germany13 00 13 30Viral impacts in the marine world from single cells to planktonic ecosystemsFlora Vincent EMBL Heidelberg Germany13 30 13 45Unravelling the role of venom in predator prey interactions using natural populations and transgenic approaches in Nematostella vectensisJoachim Surm The Hebrew University of Jerusalem Israel13 45 14 00Determining hotspots of cellular adaptation in the marine ragworm Platynereis dumeriliiTobias Gerber EMBL Heidelberg Germany14 00 14 30Coffee break14 30 15 00Cell biology of bacteria that live on the surface of animalsSilvia Bulgheresi University of Vienna Austria15 00 15 30Restoration and rehabilitation of coral microbiomesRaquel Peixoto King Abdullah University of Science and Technology Saudi Arabia Remote speaker 15 30 16 00Flash talks 2 minutes 1 slide per talk 36 James Cleland 37 Bechara Saade 38 Markus Ulrich 39 Bettina Welz and 40 Frederic Zimmer16 00 17 00Poster Session17 00Free evening Day 3 Thursday 11 May 2023 Time Europe Berlin Speaker10 00 13 00Session 3 Terrestrial SymbiosisChair Einat Segev Weizmann Institute of Science Israel10 00 10 30When the environment is another organism deciphering the insect bacteria molecular dialogue in a nutritional mutualistic endosymbiosisAnna Zaidman Remy BF2i Lab UMR INRAE INSA Lyon France Remote speaker Not available on demand10 30 10 45Caenorhabditis elegans susceptibility to virus infection is modulated by its naturally associated bacteriaRuben Gonzalez French National Center for Scientific Research CNRS France10 45 11 00Indicators and partner specificity in plant fungal interactionsLeho Tedersoo University of Tartu Estonia11 00 11 45Coffee break11 45 12 15Outsourcing immunity Symbiont mediated defense of immature life stages in beetlesMartin Kaltenpoth MPI Chemical Ecology Jena GermanyNot available on demand12 15 12 30When noise is regulation and regulation is noise how bacteria adapt their phenotypes in an uncertain environmentErik van Nimwegen University of Basel Switzerland12 30 13 00Microbiome Control of Host ImmunityYasmine Belkaid NIH National Institute of Allergy and Infectious Diseases USA Remote speaker 13 00 14 00Lunch14 00 18 00Session 4 TheoryChair Raphael Aguillon Bar Ilan University Israel 14 00 14 30Quantitative biology of microbial phenotypes in changing environmentsWenying Shou University College London UK14 30 14 45Selective capture at phenotypic boundaries enhances population evolvability in a changing environmentBhaskar Kumawat University of Michigan United States of America Remote speaker 14 45 15 00Zooming in and back out again Biochemical reflections of intergenerational environmental history across the life course with examples in ADHDSu Chu Brigham and Women s Hospital and Harvard Medical School United States of AmericaNot available on demand15 00 15 30Terraforming ecosystems from synthetic biology to community ecologyRicard Sol Catalan Institute for research and Advanced Studies Spain15 30 16 15Coffee break16 15 16 45When less isn t more the value of indigenous knowledge in understanding the relationship between the organism and its environmentPhillip Wilcox University of Otago New Zeland16 45 17 15Ecology and evolution of host microbiome networksJose Maria Montoya Teran CNRS France17 15 18 00Keynote Exploring ancient ecosystems using environmental DNARichard Durbin University of Cambridge UK18 00 19 00Dinner in Canteen19 00 21 00Drinks in ATC Rooftop lounge Day 4 Friday 12 May 2023 Time Europe Berlin Speaker09 00 10 45Session 5 Environmental adaptation in model organismsChair Giovanna Capovilla Massachusetts Institute of Technology MIT United States of America09 00 09 30Linking animal behavior to life history transition in CnidariaAissam Ikmi EMBL Heidelberg Germany09 30 09 45Clockwise adaptation CLOCK s role in nematostella s circadian response to environmental cuesRaphael Aguillon Bar Ilan University Israel09 45 10 00Short heat stress has a long term effect on mesenchymal stem cells transcriptome and their differentiation propertiesIvana Ribarski Chorev The Hebrew University Israel10 00 10 30Coffee break10 30 10 45Exposure to elevated temperature fatally disrupts nuclear divisions in the early Drosophila embryo Girish Kale Centre for Organismal Studies Heidelberg University Germany10 45 11 00Session 6 PaleogenomicsChair Giovanna Capovilla Massachusetts Institute of Technology MIT United States of America10 45 11 15Marine dinoflagellate phenology variations in a changing environmentRaffaele Siano IFREMER France11 15 11 30Closing Remarks11 30 11 45Packed Lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Maria Bacadare for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Tuesday 11 April 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 03 to confirm the exact price of the room Exzellenz HotelMeininger HeidelbergStaycity Aparthotel HeidelbergHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Vier Jahreszeiten HeidelbergLeonardo Hotel Heidelberg City Centre Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Conference shuttle bus schedule The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Bahnhofstr 9 near Penny supermarket View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Media partners Disease Models Mechanisms The Company of Biologists Journal EMBO Journal an EMBO Press journal International Union of Biochemistry and Molecular Biology Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 Leaderboard 728 90...

Detlev Arendt, Edith Heard, Maria Leptin, Fiona Watt, Detlef Weigel

8 May - 12 May 2023

Data visualisation for biology

Description This course will give insights into and practical experience in data visualisation for exploring complex and multi dimensional biological data Biological and life sciences data often consists of multiple dimensions a combination of numerical values ordered data categories and time series To make sense of this data simple plots like scatterplots barcharts and boxplots are often not enough Still visualisation is critical in gaining deep insight into the data This is why many custom visualisations originated in the biological field In this course we will dive into the topic of visualisation of complex biological data and how it can be used to gain insight into and get a feel for a dataset so that targeted analyses can be defined It will be delivered through a mixture of lectures and workshop sessions and will provide hands on experience in developing visualisations The course will focus on working with omics e g genomics transcriptomics data rather than e g imaging data Additional information The course fee is inclusive of four nights accommodation and catering including dinner We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Hybrid options are not currently available Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Monday 8 May will be a bank holiday in the UK to mark the Coronation of King Charles III The course will take place as outlined in the programme including sessions as planned on Monday 8 May Should you be selected as a participant please take extra care planning your travel to the course as public transport may be affected by the Coronation Saturday 6 May and bank holiday Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website...

Jane Reynolds

7 May - 12 May 2023

Advanced fluorescence imaging techniques

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview This practical course will cover advanced light microscopy techniques and participants will learn how to derive qualitative and quantitative insights on molecular mechanisms in cells and developing organisms Invited guest researchers together with microscopy experts from EMBL will foster an intense information flow with a balance of lectures and practical workshops The focus of the course will be on the use of fluorescence microscopy to obtain information about localisation and functions of proteins and other bio molecules at different spatial scales Audience This course is directed towards researchers in the life sciences with access to light microscopy equipment who have an immediate need to apply the techniques they will learn to solve biological problems at the cellular and molecular level in vivo As the course will be primarily focused on the advanced techniques we expect participants to have basic knowledge of light microscopy Modules resources The topics will include fluorescence microscopy techniques such as fast time lapse microscopy of living cells spinning disk and point scanning confocal microscopy light sheet microscopy of cleared samples photo manipulation as a tool multicolour single molecule localization microscopy SMLM with spectral demixing expansion microscopy FRET based techniques For demanding applications we will cover the aspects of image processing and analysis and the possibilities of microscope automation The modules will cover all necessary knowledge and demonstrate tools to conduct similar pipelines at your home lab enabling you to answer emerging biological questions Learning outcomes Get an overview of advanced fluorescence imaging techniques Obtain hands on experience setting up and running advanced experiments on modern fluorescence microscopes Discuss the possibilities and drawbacks of experiment planning and data interpretation with experts in the field This course is kindly supported by the EMBL Advanced Light Microscopy Facility This course is organised in cooperation with Evident What past participants say I highly recommend this course if you are looking to take your fluorescence microscopy experiments to the next level Josefina Marin Rojas Universidad de Chile Chile Speakers Speakers trainers and staff Alexander Aulehla EMBL Heidelberg Germany Ipek Altinoglu Abbelight France Joana Delgado Martins University of Zurich Switzerland Ulrike Endesfelder University of Bonn Germany Manuel Alexander Peter Gunkel EMBL Heidelberg Germany Aliaksandr Halavatyi EMBL Heidleberg Germany Mark Hink University of Amsterdam The Netherlands Ines H fer Evident Germany Robert Kasper Evident Germany Debora Keller Olivier Abbelight France Simone K hler EMBL Heidelberg Germany Marko Lampe EMBL Heidelberg Germany Stefan Marawske Evident Germany Felix Mikus EMBL Heidelberg Germany Pedro Pereira ITQB NOVA Portugal Marianna Poli EMBL Heidelberg Germany Irina Rakotoson PhaseView France Anjalie Schlaeppi EPFL Switzerland Stefan Terjung EMBL Heidelberg Germany Urs Ziegler University of Zurich Switzerland Scientific organisers Joana Delgado Martins University of Zurich Switzerland Manuel Alexander Peter Gunkel EMBL Heidelberg Germany Aliaksandr Halavatyi EMBL Heidleberg Germany Debora Keller Olivier Abbelight France Stefan Marawske Evident Germany Irina Rakotoson PhaseView France Course Organisers Lea Hohmann Course and Conference Manager EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Day 1 7 May 2023 Time Europe Berlin SpeakerLocation15 30 16 00RegistrationISG Hotel Seminar Room Berlin16 00 16 30WelcomeISG Hotel Seminar Room Berlin16 30 19 30Flash talks by participantsISG Hotel Seminar Room Berlin19 30 21 00DinnerISG Hotel Day 2 8 May 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG Hotel to EMBLHotel entrance08 55 09 00Safety briefing by Swetlana Krez EMBL HeidelbergCourtyard Room A B09 00 10 00Lecture Q A Concepts in Light microscopyUrs Ziegler University of Zurich SwitzerlandCourtyard Room A B10 00 11 00Lecture Q A DIY super resolution Expanding biology above diffractionPedro Matos Pereira ITQB PortugalCourtyard Room A B11 00 11 10Coffee BreakCourtyard Room A B11 10 11 30Lecture How Euro BioImaging can support your research with access to the best imaging Marianna Poli EMBL Heidelberg GermanyCourtyard Room A B11 30 12 30Lecture Q A Light sheet microscopyRobert Kasper Evident GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 1 Live cell imagingJoana Delgado University of Zurich SwitzerlandUrs Ziegler University of Zurich Switzerland Groups 1 2 3D imaging of model organisms with CLSMStefan Terjung EMBL Heidelberg GermanyStefan Marawske Evident Groups 3 4 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 45Hands on practical 2 3D imaging of model organisms with CLSMStefan Terjung EMBL Heidelberg GermanyStefan Marawske Evident Groups 1 2 DeconvolutionUrs Ziegler University of Zurich Switzerland Groups 3 4 Microscopy rooms 116 117Computer training lab18 45 19 45DinnerEMBL Canteen19 45Bus to HotelATC Entrance Day 3 9 May 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG Hotel to EMBLHotel entrance09 00 10 00Lecture Q A Adaptive Feedback MicroscopyAliaksandr Halavatyi EMBL Heidelberg GermanyCourtyard Room A B10 00 11 00Lecture Q A Visualizing chromosomes during meiosis Simone K hler EMBL Heidelberg GermanyCourtyard Room A B11 00 11 30Coffee breakCourtyard Room A B11 30 12 30Practical Setting and debugging adaptive feedback microscopy pipelinesManuel Gunkel EMBL Heidelberg GermanyComputer training lab12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 3 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyManuel Gunkel EMBL Heidelberg Germany Group 1 TBCGroup 2Deconvolution Urs Ziegler University of Zurich Switzerland Groups 3 4 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 45Hands on practical 4 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypes Aliaksandr Halavatyi EMBL Heidelberg Germany Manuel Gunkel EMBL Heidelberg Germany Groups 3 TBC Group 4 Deconvolution Urs Ziegler University of Zurich Switzerland Groups 1 2 Computer training labMicroscopy rooms 116 11718 45 20 00Pizza dinner and informal discussion20 00Bus to HotelATC entrance Day 4 10 May 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG Hotel to EMBLHotel entrance09 00 09 45Lecture Q A Introduction to SMLM from concepts to samples Debora Keller Olivier Abbelight FranceCourtyard Room A B09 45 10 45Lecture Q A Measuring interactions and biosensors using FRETMark Hink University of Amsterdam The NetherlandsCourtyard Room A B10 45 11 15Coffee break11 15 12 30Practical Preparation of expansion microscopy samplesPedro Matos Pereira ITQB PortugalTraining Lab12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 5 Multicolor Single molecule Localization Microscopy with Spectral DemixingDebora Keller Olivier Abbelight France Group 1 Ultra thin light sheet microscope with automated multi scale imaging capabilitiesRobert Kasper Evident Germany Group 2 FRETMark Hink University of Amsterdam The Netherlands Group 3 Imaging expanded samplesPedro Matos Pereira ITQB Portugal Group 4 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 30Hands on practical 6 Ultra thin light sheet microscope with automated multi scale imaging capabilitiesRobert Kasper Evident Germany Group 1 Multicolor Single molecule Localization Microscopy with Spectral DemixingDebora Keller Olivier Abbelight France Group 2 Imaging expanded samplesPedro Matos Pereira ITQB Portugal Group 3 FRETMark Hink University of Amsterdam The Netherlands Group 4 Microscopy rooms 116 11718 30Bus to dinner downtownATC entrance Day 5 11 May 2023 Time Europe Berlin SpeakerLocation09 00 10 00Lecture Q A Visualizing chromosomes during meiosisSimone K hler EMBL Heidelberg Germany Q A Courtyard Room A B10 00 11 00Lecture Q A We can start testing next month practical considerations for spatial transcriptomics and multiplexing Anjalie Schlaeppi EPFLCourtyard Room A B11 00 11 30Coffee breakCourtyard Room A B11 30 12 30Lecture Q A Visualizing cellular life From single cell imaging to in vivo single molecule biophysics biochemistry and structural micro biologyUlrike Endesfelder University of Bonn GermanyCourtyard Room A B12 30 13 30LunchEMBL Canteen13 30 16 00Hands on practical 7 FRETMark Hink University of Amsterdam The Netherlands Group 1 Imaging expanded samplesPedro Matos Pereira ITQB Portugal Group 2 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyManuel Gunkel EMBL Heidelberg Germany Group 3 Multicolor Single molecule Localization Microscopy with Spectral DemixingDebora Keller Olivier Abbelight France Group 4 Microscopy rooms 116 11716 00 16 15Coffee breakCourtyard Room A B16 15 18 45Hands on practical 8 Imaging expanded samplesPedro Matos Pereira ITQB Portugal Group 1 FRETMark Hink University of Amsterdam The Netherlands Group 2 Multicolor Single molecule Localization Microscopy with Spectral DemixingDebora Keller Olivier Abbelight France Group 3 Applying adaptive feedback microscopy for high throughput photoactivation of specific cell phenotypesAliaksandr Halavatyi EMBL Heidelberg GermanyManuel Gunkel EMBL Heidelberg Germany Group 4 Microscopy rooms 116 11718 45 19 45DinnerEMBL Canteen19 45 20 45Informal Q A discussion and drinksCourtyard Room A B20 45Departure to HotelATC entrance Day 6 12 May 2023 Time Europe Berlin SpeakerLocation09 00 10 30Practical FRET data analysisMark Hink University of Amsterdam The NetherlandsComputer training lab10 30 11 00Coffee breakoutside Computer training lab11 00 12 30Practical SMLM data analysisMarko Lampe EMBL Heidelberg GermanyComputer training lab12 30 13 30LunchEMBL Canteen13 30 14 45Preparation of student presentationsComputer training lab14 45 16 15Student presentationsComputer training lab16 15 16 40Wrap up of course and departure16 40Bus to Heidelberg main stationATC entrance Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 550PhD Student 550Industry 1100 A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 5 nights 7 12 May 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code MIC23 02 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings Please see the bus schedule here Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Aliaksandr Halavatyi, Stefan Marawske, Rainer Pepperkok, Stefan Terjung

3 May 2023

Historical perspectives on plant science databases

Description This webinar will discuss the history of database development in the plant sciences with a focus on European efforts to build international cross institutional genebank databases Although accounts of these often focus on the need for well curated and cross linked databases to adequately serve research communities it is equally important to consider the political and economic motivations behind database development Exploring the history of data management in the plant sciences can potentially help researchers recognise and navigate contemporary challenges...

Helen Anne Curry

26 April 2023

Applications and impacts of the BrAPI project on plant breeding

Description Modern genomic breeding methods rely heavily on very large amounts of phenotypic and genotypic data presenting new challenges in effective data management and integration The datasets are often large and complex and the data is often stored on multiple systems sometimes separated by country and organisation As the common analyses methods increasingly require aggregation of datasets from diverse sources data exchange between disparate systems becomes a challenge This webinar will be an introduction to The Breeding API BrAPI Project The BrAPI Project began in 2014 when a small group of plant breeding and technology experts came together to try to standardise their data Since then BrAPI has become internationally accepted as one of the primary data exchange standards in the plant breeding domain This webinar will give an overview of what BrAPI is how it works what it is capable of and the impact the project has had so far on the community...

Peter Selby

25 April - 28 April 2023

Brain genome: regulation, evolution, and function

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety recommendations if attending the on site event Symposium overview This symposium explores the many ways by which the genome is regulated in the brain in order to support neural function and plasticity The extraordinary complexity of the brain places unique demands on the genome How are several hundreds of different neural types specified by the same genetic instructions Does the genome provide information that guides their connectivity How is neural activity regulated by and how does it affect genome output We will explore these fundamental questions from the standpoint of transcriptional regulation and chromatin based processes including but not limited to histone marks and variants chromatin topology and folding coding and noncoding RNAs transposable elements and DNA modifications The conference aims to bring together neuroscientists and experts in genome regulation It will cover a broad range of experimental approaches and model systems from biochemistry to single cell genomics from worms to human organoids Overall the conference will address the impact of genome regulation on unique features of the brain its excitable nature exquisite response to the environment and parallel processing capacity with the longer term vision of understanding how defective genome regulation can give rise to brain disease Session topics Interplay between gene regulation and neuronal activity Genomic regulation of brain plasticity and behaviour Chromatin variations in the brain From one genome to many neurons neurodevelopment and neural diversity Speakers Angel Barco Instituto de Neurociencias UMH CSIC Spain Brenda Bloodgood University of California San Diego USA Roberto Bonasio University of Pennsylvania USA remotely Claude Desplan New York University USA Yukiko Gotoh University of Tokyo Japan Magdalena G tz Ludwig Maximilian University of Munich and Helmholtz Zentrum M nchen Germany Johannes Gr ff EPFL Switzerland Elizabeth Heller University of Pennsylvania USA Johan Jakobsson Lund University Sweden Daniel Kronauer The Rockefeller University USA Ryan Lister The University of Western Australia Australia Stavros Lomvardas Columbia University USA Ana Martin Villalba German Cancer Research Center Germany Ian Maze Icahn School of Medicine at Mount Sinai USA Lindy McBride Princeton University USA Kyung Min Noh EMBL Heidelberg Germany Coleen T Murphy Princeton University USA Gaia Novarino Institute of Science and Technology Austria Austria Sergiu Pasca Stanford University USA Ana Pombo Max Delbr ck Center for Molecular Medicine Germany Anne Sch fer Max Planck Institute for Biology of Ageing Germany Alex Schier University of Basel Switzerland Pelin Cayirlioglu Volkan Duke University USA Scientific organisers Roberto Bonasio University of Pennsylvania USA remotely Matthieu Boulard EMBL Rome Italy Magdalena G tz Ludwig Maximilian University of Munich and Helmholtz Zentrum M nchen Germany Kyung Min Noh EMBL Heidelberg Germany Conference organiser Iva Gavran EMBL Heidelberg Germany Programme Got something to say Tweet it EESBrainGenome For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Programme is subject to change Day 1 Tuesday 25 April 2023 Time Europe Berlin Speaker12 00 13 30Registration and refreshments light lunch 13 30 13 45Opening remarks13 45 18 00Session 1 From one genome to many neurons neurodevelopment and neural diversityChair Gaia Novarino Institute of Science and Technology Austria Austria13 45 14 15Chromatin level regulation of neural stem cell fate during mouse neocortical developmentYukiko Gotoh The University of Tokyo JapanNot available on demand14 15 14 45Epigenetic etiology of intellectual disabilityAngel Barco Instituto de Neurociencias UMH CSIC SpainNot available on demand14 45 15 00Joint epigenome profiling reveals cell type specific gene regulatory programs in human cortical organoidsBoyan Bonev Helmholtz Zentrum M nchen Germany15 00 15 15Deep learning from scMultiomes suggests conserved gene regulatory codes for mammalian and avian brain cell typesNikolai Hecker VIB KU Leuven Center for Brain Disease Research Belgium15 15 15 45Transposable elements and the evolution of the human brainJohan Jakobsson Lund University Sweden15 45 16 15Coffee Break and Meet the speakers with Yukiko Gotoh Angel Barco Johan Jakobsson16 15 16 45From Stem Cells to Organoids to Assembloids and Toward Building Human Circuits in Living SystemsSergiu Pasca Stanford University USA16 45 17 00Mapping Neuronal Networks in Cerebral Organoids with Single cell Transcriptional ResolutionRamsey Najm Institute of Molecular Biotechnology Austria17 00 17 15Primate expressed EPIREGULIN promotes basal progenitor proliferation in the developing neocortexMareike Albert Technical University Dresden GermanyNot available on demand17 15 17 45Reconstructing cellular biographiesAlex Schier Biozentrum University of Basel Switzerland17 45 18 00Development and evolution of the mammalian cerebellum at single cell resolutionMari Sepp Heidelberg University GermanyNot available on demand18 00 19 00Poster previews and Meet the speakers with Sergiu Pasca and Alex Schier19 00 20 30Canteen dinner20 30 22 00Networking in the ATC Rooftop lounge Day 2 Wednesday 26 April 2023 Time Europe Berlin Speaker09 15 12 15Session 2 Genomic regulation of brain plasticity and behaviorChair Boyan Bonev Helmholtz Zentrum M nchen Germany09 15 09 45Autism associated chromatin dysregulation hinders synaptic plasticityGaia Novarino Institute of Science and Technology Austria Austria09 45 10 00Sites of transcription initiation drive mRNA isoform selection in the brainValerie Hilgers Max Planck Institute of Immunobiology and Epigenetics Germany10 00 10 15Adaptation phenotypic plasticity and the brain in a changing worldCelia Schunter University of Hong Kong Hong Kong10 15 10 45Coffee Break and Meet the speakers with Gaia Novarino10 45 11 15Protein monoaminylation in brain novel mechanisms of neural development plasticity and diseaseIan Maze Howard Hughes Medical Institute Icahn School of Medicine at Mount Sinai United States of America11 15 11 30Manipulation of neural stem cell fates through activation of global protein translation rates using a novel CRISPR approachStefan Stricker Ludwig Maximilians University of Munich Helmholtz Zentrum Germany11 30 11 45The regulatory determinants of modern human brain development and evolutionAlessandro Vitriolo Human Technopole Italy11 45 12 15Epigenetic editing for the study of addictionElizabeth Heller University of Pennsylvania USA12 15 13 45Lunch and Meet the speakers with Ian Maze and Elizabeth Heller13 45 17 00Session 2 Genomic regulation of brain plasticity and behavior continued Chair Ryan Lister The University of Western Australia Australia13 45 14 15Pheromone communication in antsDaniel Kronauer The Rockefeller University USANot available on demand14 15 14 30Convergent and complementary selection shaped the evolution of social behavior in beesSarah Kocher Princeton University United States of America14 30 14 45L1 retrotransposons drive human neuronal transcriptome complexity and functional diversificationDiahann Atacho Lund University Sweden14 45 15 15EGL 30 GNAQ activation rejuvenates age related cognitive decline in worms and mammals Coleen T Murphy Princeton University USA15 15 15 45Coffee Break and Meet the speakers with Daniel Kronauer Coleen Murphy and Carolyn McBride15 45 16 15Socially induced brain plasticity and behavioral reprogramming in antsRoberto Bonasio University of Pennsylvania USA remote talk 16 15 16 30Nup153 regulates activity dependent gene expression in neuronsAbhinav Soni German Center for Neurodegenrative Diseases Dresden GermanyNot available on demand16 30 17 00A map of neuronal diversity on mosquito antennae reveals rampant co expression and co option of olfactory receptorsCarolyn McBride Princeton University USA17 00 17 30Flash talksBonefas Katherine 53 Porrua Odil 65 Kentro James 71 Martelli Carlotta 81 Rowland Megan 93 Soliman Azza 99 Winter Julia 111 Yip Kwok Yui Reymond Tony 11317 30 19 00Poster Session 1 odd with beer and light refreshments19 15Free evening bus downtown Day 3 Thursday 27 April 2023 Time Europe Berlin Speaker09 30 12 45Session 3 Interplay between gene regulation and neuronal activity Chair Lindy McBride Princeton University USA09 30 09 45Histone H3K79 methylation demarcates an epigenetic barrier of progenitor differentiation and neuronal maturation in cerebral cortex and hippocampus developmentTanja Vogel University of Freiburg Germany 09 45 10 00Condensins restrict retrotransposable element expression and activity in neural stem cells to promote Drosophila brain developmentMichelle Longworth Cleveland Clinic Lerner Research Institute United States of America10 00 10 30Novel mechanisms of endogenous and induced neurogenesisMagdalena G tz Ludwig Maximilian University of Munich and Helmholtz Zentrum M nchen Germany10 30 11 00Coffee Break and Meet the speakers with Magdalena G tz11 00 11 30Transcriptional regulation of inhibitory synapses impacts place field coding and stabilityBrenda Bloodgood University of California San Diego USA11 30 11 45Spatial enhancer activation determines inhibitory neuron identityElena Dvoretskova Max Planck Institute for Biological Intelligence GermanyNot available on demand11 45 12 15Chromatin plasticity predetermines neuronal eligibility for memory trace allocationJohannes Gr ff EPFL Switzerland12 15 12 45Evolution of neural diversityClaude Desplan New York University USA12 45 14 15Lunch and Meet the speakers14 15 17 15Session 4 Chromatin variations in the brainChair Stefan Stricker Ludwig Maximilians University of Munich Helmholtz Zentrum Germany14 15 14 45The effect of social experience on gene expression circuit function and behaviorsPelin Volkan Duke University USA14 45 15 00linc mipep and linc wrb encode micropeptides that regulate chromatin accessibility in vertebrate specific neural cellsValerie Tornini Yale University United States of America15 00 15 15Regulatory genomics of primate astrocyte evolutionAleksandra Pekowska Nencki Institute of Experimental Biology Polish Academy of Sciences Poland15 15 15 45Olfactory receptor mRNAs as selfish lnRNAs that promote transcriptional singularityStavros Lomvardas Columbia University USA15 45 16 15Coffee Break and Meet the speakers with Pelin Volkan Stavros Lomvardas and Ana Martin Villalba16 15 16 45The molecular secrets of stemness in the adult healthy and injured brain Ana Martin Villalba German Cancer Research Center DKFZ Germany16 45 17 00HP1 Deficiency Results in De Repression of Endogenous Retroviruses and Induction of Neurodegeneration via Complement Andrew Newman Charit Universit tsmedizin Berlin Germany17 00 17 15Epigenetically distinct synaptic architecture in clonal compartments in the teleostean dorsal palliumYasuko Isoe Harvard University United States of America17 15 17 45Flash talksBurgos Ruiz Ana Mar a 54 Castilla Vallmanya Laura 56 Gracia Diaz Carolina 66 Horvath Vivien 68 Jacobs Jelle 70 Kitanishi Yuki 72 Krick Keegan 74 Mall Moritz 80 Schofield Mia 96 Villamor Paya Marina 108 Wiseglass Gil 11217 45 19 15Poster Session 2 even with beer and snacks19 15 21 00Conference dinner21 00 23 00Live music and drinks Day 4 Friday 28 April 2023 Time Europe Berlin Speaker09 15 12 30Session 4 continued Chromatin variations in the brainChair Elizabeth Heller University of Pennsylvania USA09 15 09 45Specialization of 3D genome structure in different brain cells and cell stateAna Pombo Max Delbr ck Center for Molecular Medicine Germany09 45 10 00L1 RNAs regulate cortical development by tuning PRC2 activityDamiano Mangoni Istituto Italiano di Tecnologia Italy10 00 10 30The operational principles of neuron microglia circuitsAnne Schaefer Max Planck Institute for Biology of Ageing Germany10 30 11 00Coffee Break and Meet the speakers with Ana Pombo Anne Schaefer Ryan Lister and Kyung Min Noh11 00 11 30Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single cell resolutionRyan Lister The University of Western Australia Australia11 30 11 45SATB2 organizes the 3D genome architecture of cognition in cortical neuronsGalina Apostolova Medical University of Innsbruck Austria11 45 12 00A PRC2 network controls neural progenitor death division and differentiationJamy Peng St Jude Children s Research Hospital United States of America12 00 12 30Functional single cell genomics of transcription factors and chromatin regulators associated with neurodevelopmental disordersKyung Min Noh EMBL Heidelberg Germany12 30 12 45Closing Remarks and Poster prize12 45 13 15Packed lunch and departure Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600 On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Iva Gavran for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO as well as other partner institutions in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference CPP and EMBO travel grants The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops Boehringer Ingelheim Stiftung travel grants up to 800 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe as well as the cost of registration up to 1 800 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe as well as the cost of registration The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 27 March 2023 in some cases at special rates Please email the hotel directly quoting the booking code EES23 02 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz HotelMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Conference shuttle bus schedule The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual Participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsorsAAAS Science Advances Active Motif BGI Genomics Cell ResearchEvent supporters Media partners EMBO reports an EMBO Press journal FEBS Journal a FEBS Press journal FEBS Letters a FEBS Press journal International Union of Biochemistry and Molecular Biology Bio Essays a Wiley Online Library Advanced Biology a Wiley Online Library Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Roberto Bonasio, Matthieu Boulard, Magdalena Götz, Kyung-Min Noh

25 April - 27 April 2023

Bioinformatics resources for protein biology

Description Are you aware of the wide range of protein data resources that can easily be accessed and explored to enhance your research Do you want to know more about the sequence of your protein and its functions Wondered whether a structure of your protein exists and how to explore it Want to know more about the potential complexes and reaction pathways your protein of interest is involved in giving you a better overview of its biological context This short virtual course will introduce you to data resources and tools developed by EMBL EBI that can help you in your protein studies During the first three days you will learn about how to browse retrieve and use EMBL EBI protein data in theory Those who are interested in learning more about programmatic access to EMBL EBI protein resources can attend an optional section on this topic on 25 April 2023 For an introduction to the concept of web services and how you can use them to access the tools and data available at EMBL EBI please watch our webinar You will then be provided exercises for each resource you will work through on your own in the following week with remote trainer support available if needed We will meet again on 3 May 2023 to discuss issues that occurred while working through the material in more detail Additional information Please note that we will operate this course virtually Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic Virtual course Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there may be a brief induction session Participants will need to be available between the hours of 09 45 16 30 GMT each day of the course Trainers will be available to assist answer questions and provide further explanations during these times...

Juanita Riveros

19 April 2023

Kew tree of life project: discovering the phylogeny of all flowering plants

Description High throughput sequencing has transformed approaches to phylogenetic analysis allowing the construction of trees based on multiple loci and consideration of incongruence between nuclear and plastid data This webinar will highlight how the Hyb Seq method enriches whole genome sequence data for target genes and can be used on preserved specimens enabling a cost effective and practicable strategy for the rigorous investigation of plant evolutionary relationships over a broad taxonomic scope The Royal Botanic Gardens Kew has already generated a phylogeny covering over half of all flowering plant genera and aims to complete the tree at the generic level by 2025...

Bill Baker

18 April 2023

From transcriptomics to mechanistic models of signalling

Description Event registration is now full Cellular signalling networks are the communication pathways that govern the behaviour of cells They allow cells to receive and process external signals such as growth factors and hormones and respond appropriately by activating specific gene expression programs or inducing cellular behaviours like proliferation migration and differentiation Disruptions in these signalling networks can lead to various diseases including cancer metabolic disorders and immune disorders Understanding the regulatory mechanisms of signalling networks is critical to developing effective therapies for these diseases One approach to discover signalling network alterations from omics data is through the use of upstream regulatory pathway analysis which aims to identify the transcription factors and upstream signalling regulators that control the expression of downstream genes This can be achieved through the joint analysis of omics data and the signalling network structure using methods such as CARNIVAL By using powerful algorithms and general purpose integer optimization solvers CARNIVAL explores the vast space of potential signalling alterations to identify a parsimonious signalling network that explains the measurements In this course participants will learn how to process differential gene expression data to estimate transcription factor activities with DecoupleR obtain and process prior knowledge networks with OmniPath and pypath and use CARNIVAL to infer signalling networks...

Daniel V. Thomas Lopez

17 April - 24 April 2023

Microbial metagenomics: a 360º approach

Description OverviewSpeakersPreliminary programmePractical informationSponsorsMedia kit Overview Course overview The course focuses on the highly interdisciplinary topic of metagenomics During the course participants will receive an overview of state of the art genomic technologies and bioinformatic tools A balanced approach of lectures and practical sessions will provide a general background and the latest advancements in the field as well as its relationship with other disciplines The course will start with training the participants about experimental design and the preparation of their own metagenomic libraries with soil or their environmental samples The metagenomic DNA will be sequenced onsite using third generation sequencing technologies and subsequent data analysis Thus the students have a unique opportunity to work on the complete workflow from sample preparation to data analysis This updated course version will also address cutting edge single cell microbial genomics during practical Bioinformatics analysis is a key part of the course where students will learn how to process data from raw sequences to the application of algorithms for analysing metagenomic datasets Trainers will provide short lectures with follow up hands on exercises in order to have the participants learning and assessing their knowledge Audience This course is aimed at advanced PhD students and post doctoral researchers who are doing or planning to start research in the field of metagenomics Modules resources Experimental design Extraction of metagenomic DNA Construction of metagenomic libraries Single cell microbial genomics 3rd generation sequencing Nanopore Bioinformatic analysis of metagenomic data data standards and submission processing of raw data assembly functional annotation overview of databases retrieval and analysis tools Learning outcomes Construct your own metagenomic library Analyse and organise your data Interpret results explore different databases use different retrieval and analysis tools Sequence analysis What past participants say about the course This course gave me the opportunity to learn from my coursemates and understand the software used in metagenomics The speakers were friendly and are always ready to answer our research questions and provide us with valuable advice and comments Lee Hwei Huih The University of Hong Kong Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Vladimir Benes EMBL Heidelberg Germany Josefa Ant n Botella University of Alicante Spain Giuseppe D Auria FISABIO Sequencing and Bioinformatics Spain Jos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA Spain Daniel Huson University of T bingen Germany Kostas Konstantinidis Georgia Institute of Technology USA Eugeni Belda IRD UMMISCO INSERM NutriOmique France Arantxa L pez L pez Hospital Can Misses Spain Gabrielle Potocki Veronese French National Institute for Agricultural Research INRA France Mariana Reyes Prieto FISABIO Sequencing and Bioinformatics Spain Lorna Richardson EMBL EBI UK Kristian Vlahovicek University of Zagreb Croatia Tobias Wenzel Pontificia Universidad Cat lica de Chile Chile Georg Zeller EMBL Heidelberg Germany Daphne Welter EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg Germany Luis Miguel Rodriguez R University of Innsbruck Austria Dienty Hendrina Maria Johanna Hazenbrink EMBL Heidelberg Germany Lukas Mathur EMBL Heidelberg Germany Jean Karim H rich EMBL Heidelberg Germany Yi Sun EMBL Heidelberg Germany Scientific organisers Vladimir Benes EMBL Heidelberg Germany Giuseppe D Auria FISABIO Sequencing and Bioinformatics Spain Jos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA Spain Elisabeth Zielonka EMBL Heideilberg Germany Course organisers Diah Yulianti EMBL Heidelberg Germany Swetlana Krez EMBL Heidelberg Germany Preliminary programme Got something to say Tweet it EMBOMetaG Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Onboarding day Monday 3 April 2023 TimeSpeakerLocation16 00 17 00 Overview of pre course work introduction to course content on EMBL eCampus Virtual Day 1 Monday 17 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Welcome and EMBL overviewElisabeth Zielonka EMBL Heidelberg Germany Courtyard Room A B09 15 09 30 Introduction to Training Lab and House notesEMBL Heidelberg Germany Courtyard Room A B09 30 09 45Welcome and IntroductionsJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA Spain Courtyard Room A B09 45 10 45 Flash talks participantsElisabeth Zielonka EMBL Heidelberg Germany Courtyard Room A B10 45 11 00 BREAK11 00 12 00 Metagenomics Concepts historical milestones and next advanceJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA Spain Courtyard Room A B12 00 13 00 LUNCH EMBL Canteen13 00 14 00 Metagenomics library preparation for NGSVladimir Benes EMBL Heidelberg GermanyCourtyard Room A B14 00 15 00 Group ActivityChallenges and Expectations Courtyard Room A B15 00 16 00 The impact of Metagenomics on genes and genomes discoveryGabrielle Potock i Veronese INRA LISBP FranceCourtyard Room A B16 00 16 30 BREAK 16 30 17 30 What brings a metagenomic approach in cardiometabolic and nutrition related disorders Eugeni Belda IRD UMMISCO INSERM NutriOmique France Courtyard Room A B17 30 20 00 Poster Session 1 and Pizza dinnerHelix A and Rooftop Lounge Day 2 Tuesday 18 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Quick overview of the dayJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA Spain Courtyard Room A B09 15 10 30 PRACTICAL 1 Extraction of metagenomic DNA in groups from soil samplesJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses Spain Training Lab A B10 30 11 00 BREAK 11 00 12 30 PRACTICAL 2Quality control of DNA samples and Nanopore 16S PCR set upDaphne Welter EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyTraining Lab A B12 30 13 30 LUNCHEMBL Canteen13 30 14 30Discussion of metagenomic DNA Extraction ResultsJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainCourtyard Room A B14 30 15 30Metagenomics and other culture independent tools to study virus communitiesJosefa Ant n Botella University of Alicante SpainCourtyard Room A B15 30 16 45PRACTICAL 2Nanopore 16S PCR cleanup finishing library preparation and starting sequencing run followed by Genomics Core Facility TourDaphne Welter EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyTraining Lab A B16 45 17 15BREAK17 15 19 15PRACTICAL 2Nanopore 16S analysis DNA cleanup and Sequencing startDaphne Welter EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyTraining Lab A BGeneCore Facility19 15 19 30Group activity Description of Case StudiesElisabeth Zielonka EMBL Heidelberg GermanyJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainGiuseppe D Auria FISABIO SpainCourtyard Room A B19 40DINNER Hotel ISG Day 3 Wednesday 19 April 2023 Time Europe Berlin Speaker Location 09 00 09 15Quick overview of the dayJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainCourtyard Room A B09 15 09 45PRACTICAL 1Test digestion conditions for metagenomic DNA and preparation of agarose gelsJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainTraining Lab A B 09 45 11 00PRACTICAL 3Practical introduction Single cells genomics in dropletsTobias Wenzel EMBL Heidelberg GermanyTraining Lab A B11 00 11 15BREAK11 15 12 30PRACTICAL 1Digestion of metagenomic DNA for cloning in the libraries once that digestion conditions are determined Jos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainTraining Lab A B12 30 13 30LUNCHEMBL Canteen13 30 14 30PRACTICAL 1Purification from gel of the digested metagenomic DNAJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainTraining Lab A B14 30 15 00BREAK15 00 17 00PRACTICAL 1Cloning of the metagenomic DNA overnight ligationEduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainTraining Lab A B 17 00 19 30 PRACTICAL 3Practical single cell microbial genomics Droplet generation for single cell genomics and PCR set upTobias Wenzel EMBL Heidelberg GermanyTraining Lab A B19 30 20 30DINNER Hotel ISG Day 4 Thursday 20 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Quick overview of the dayJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainCourtyard Room A B09 15 11 00 PRACTICAL 1Transformation in E coli of the libraryJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainTraining Lab A B11 00 12 00 Methodological discussion of practical session 1 Metagenomics experimental design Common shortcoming and pitfallsJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainCourtyard Room A B12 00 13 00 LUNCHEMBL Canteen13 00 14 30PRACTICAL 4Solving problems and questions Introduction to Linux and R based on pre recorded lecture 1 and 2Giuseppe D Auria FISABIO SpainTraining Lab A B14 30 15 30Metabolomic profiling of microbial communitiesMariana Reyes Prieto FISABIO SpainCourtyard Room A B15 30 16 00 BREAK16 00 17 00 Pacific Bioscience PacBio sequencing for metagenomicsVladimir Benes EMBL Heidelberg GermanyCourtyard Room A B18 15Bus leaves at 17 45Free evening with tour of Heidelberg Day 5 Friday 21 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Quick overview of the dayGiuseppe D Auria FISABIO SpainCourtyard Room A B09 15 10 00 PRACTICAL 1Analysis of some colonies from the metagenomic libraries Interpretation of resultsJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainArantxa Lopez Hospital Can Misses SpainTraining Lab A B 10 00 10 30 BREAK10 30 11 15 Metatranscriptomics applied to the study microbial communitiesJos Eduardo Gonz lez Pastor Center of Astrobiology CSIC INTA SpainCourtyard Room A B11 15 12 00Case studiesCourtyard Room A B12 00 13 30 LUNCHEMBL Canteen13 30 14 30 Functional and taxonomic analysis with MgnifyLorna Richardson EMBL EBI Hinxton UKCourtyard Room A B14 30 16 30PRACTICAL 5Functional and taxonomic analysis with MgnifyGrisel Alejandra Escobar Zepeda EMBL EBI Hinxton UKLorna Richardson EMBL EBI Hinxton UKComputer Training Lab16 30 19 30 PRACTICAL 3Visualization of droplets and single cell analysis with flexible coffee breakTobias Wenzel EMBL Heidelberg GermanyTraining Lab A B19 30 22 00 BBQ DINNER Hotel ISG Day 6 Saturday 22 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Quick overview of the dayGiuseppe D Auria FISABIO SpainCourtyard Room A B09 15 11 00Introduction to 16S rDNA profiling Illumina PacBio Giuseppe D Auria FISABIO SpainComputer Training Lab11 00 11 15 BREAK11 15 12 15PRACTICAL 6Practical to 16S rDNA profiling Illumina PacBio Giuseppe D Auria FISABIO SpainComputer Training Lab12 15 13 15 LUNCHEMBL Canteen13 15 14 15PRACTICAL 6Practice to 16S rDNA profiling Illumina PacBio Giuseppe D Auria FISABIO SpainComputer Training Lab14 15 16 00PRACTICAL 7The microbial species definition and its challenges The MiGA web server for species identification the genome equivalent of RDP SilvaSSU web serversKostas Konstantinidis Georgia Institute of Technology USALuis Miguel Rodriguez R University of Innsbruck AustriaComputer Training Lab16 00 16 30 BREAK16 30 18 30 PRACTICAL 8Analysis of 100s of metagenomes shows that bacterial species existTools for specialized analyses of metagenomesKostas Konstantinidis Georgia Institute of Technology USALuis Miguel Rodriguez R University of Innsbruck AustriaComputer Training Lab18 30 20 00 Poster session 2 and dinnerHelix A and Rooftop Lounge Day 7 Sunday 23 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Quick overview of the dayKristian Vlahovicek University of Zagreb CroatiaCourtyard Room A B09 15 11 15 PRACTICAL 9Metagenomic assembly ORF finding functional annotationGiuseppe D Auria FISABIO SpainComputer Training Lab11 15 11 30 BREAK11 30 12 30 Analysis Tools Overview INCA MILC and MELPKristian Vlahovicek University of Zagreb CroatiaComputer Training Lab12 30 13 30 LUNCHEMBL Canteen13 30 15 30 PRACTICAL 10INCAKristian Vlahovicek University of Zagreb CroatiaComputer Training Lab15 30 16 00 BREAK16 00 18 00 Student presentation preparation time Case StudiesAll trainers and speakersCourtyard Room A B19 00DINNERDowntown Day 8 Monday 24 April 2023 Time Europe Berlin Speaker Location 09 00 09 15 Quick overview of the dayGiuseppe D Auria FISABIO SpainCourtyard Room A B09 15 10 15 Nanopore 16S sequencing results EPI2ME Laura Villacorta EMBL Heidelberg GermanyCourtyard Room A B10 15 10 45BREAK10 45 12 00 PRACTICAL 11MEGANDaniel Huson University of T bingen GermanyComputer Training Lab12 00 13 00LUNCHEMBL Canteen 13 00 14 00PRACTICAL 11MEGANDaniel Huson University of T bingen GermanyComputer Training Lab14 00 16 30Group activity and presentations Case StudiesCourtyard Room A B16 30 16 45BREAK16 45 17 15Wrap up and conclusionsCourtyard Room A B18 00DINNERHotel ISG Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of 16 April to 24 April 2023 9 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 31 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings Please see the schedule here Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partners Event sponsors Event supporters Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Giuseppe D´Auria, José Eduardo González-Pastor, Elisabeth Zielonka

17 April - 18 April 2023

EuroFAANG AQUA-FAANG workshop: methods to use and reuse the AQUA-FAANG data and Ensembl resources to advance science

Description This one and a half day workshop will provide detailed training on methods to use and reuse the wealth of data generated by the EuroFAANG AQUA FAANG project AQUA FAANG aims to improve understanding the genome function and usage of genotype to phenotype prediction in the six most important European farmed fish species EUROPEAN SEABASS GILTHEAD SEABREAM RAINBOW TROUT ATLANTIC SALMON COMMON CARP TURBOT The workshop will primarily focus on the comprehensive and integrated annotation of these six species by the Ensembl genome browser The course will also include a deeper dive from the Ensembl analysis teams into gene annotation and regulation and demonstrations of the specific analyses and research conducted by AQUA FAANG scientists...

Peter Harrison

12 April 2023

Pangenomics and machine learning for crop improvement

Description The changing climate and increasing human population mean that we need to accelerate the production of improved crop varieties Advances in genomics and phenomics are helping to accelerate crop improvement but the quantity and diversity of data being generated is vast and needs new methods for integrated analysis Artificial intelligence AI approaches provide one solution to this analysis challenge This webinar will provide an overview on recent advances in pangenomics and application of machine learning and deep learning for crop genomic and phenomic data analysis...

Dave Edwards

28 March - 31 March 2023

Visualizing biological data (VIZBI 2023)

Description This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety recommendations if attending the on site event Conference overview Visualisation is increasingly important in life science as data grows rapidly in volume and complexity The VIZBI initiative is an international conference series bringing together researchers developing and using computational visualisation to address a broad range of biological research areas the conference also attracts participation from medical illustrators graphic designers and graphic artists VIZBI is held annually usually alternating between Europe and the USA More information on VIZBI can be found at https vizbi org...

Barbora Kozlikova, Marc A. Marti-Renom, Andrea Schafferhans, Nico Scherf, Michelle Scott, Srigokul Upadhyayula

28 March - 31 March 2023

Introduction to metabolomics analysis

Description This course will provide an introduction to metabolomics through lectures and hands on sessions using publicly available data software and tools Participants will become familiar with the current state of experimental design data acquisition LC MS MS imaging processing and modelling In addition they will learn about community standards and sharing in metabolomics particularly through using the EMBL EBI s MetaboLights repository and Galaxy infrastructure Participants will learn through hands on tutorials to use tools available for data analysis and data submission Additionally case studies will be used to discuss and show how to employ the week s learning In person course We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Additional information The course fee is inclusive of three nights accommodation and catering including dinner Please note that we will operate this course face to face at EMBL EBI Hinxton Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website...

Jane Reynolds

26 March - 1 April 2023

Measuring translational dynamics by ribosome profiling

Description OverviewSpeakers trainers and staffProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview Regulation of translation is key in the control of gene expression playing a critical role in many biological and pathophysiological settings In the last decade methodological advances have provided comprehensive insights into cellular transcriptomes and proteomes however the systems wide analysis of translation remained an unsolved experimental challenge The advent of ribosome profiling provided the methodological basis for comprehensive transcriptome wide analyses of translation at sub codon resolution by the precise and high throughput determination of ribosomal positions on mRNA Its application in a variety of organisms yielded novel insights into protein synthesis and its dynamic regulation significantly advancing our understanding of the post transcriptional regulation of gene expression Audience The course is aimed at PhD students and early post doctoral researchers who are entering the field of posttranscriptional regulation of gene expression Learning outcomes The practical course Measuring translational dynamics by ribosome profiling aims to a generate a detailed theoretical understanding of ribosome profiling its variations to address specific aspects of translation and its experimental strengths and limitations b provide hands on wet lab training to perform ribosome profiling experiments with the aim to understand and master the critical steps of the experimental workflow and to train the participants to independently perform and adapt similar experiments in their own laboratories c provide hands on bioinformatics training on processing the high throughput sequencing data the quality control and on the use of specialised tools for data generated by ribosome profiling Speakers trainers and staff Pavel Baranov University College Cork Ireland Vladimir Benes EMBL Heidelberg Germany Alla Fedorova University College Cork Ireland Rachel Green Johns Hopkins University School of Medicine USA Nicholas Ingolia University of California Berkeley USA Yeji Kim University of Bern Switzerland Leon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Marina Rodnina Max Planck Institute for Biophysical Chemistry Germany Noam Stern Ginossar Weizmann Institute of Science Israel Jack Tierney University College Cork Ireland Michael VanInsberghe Hubrecht Institute KNAW Netherlands Anne Willis MRC Toxicology UK Oza Zaheed University College Cork Ireland Elisabeth Zielonka EMBL Heidelberg Germany Scientific organisers Pavel Baranov University College Cork Ireland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Aline Schnieder Course and Conference Officer EMBL Heidelberg Germany Programme Got something to say Tweet it with EMBORiboProf Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Monday 13 March 2023 Time Europe Berlin SessionLocation14 00 15 30Onboarding session Welcome introduction to material and software testing Virtual Day 1 Sunday 26 March 2023 Time Europe Berlin SessionLocation13 15Bus to EMBL ATCISG Hotel13 30 14 00Registration and light refreshmentsCourtyard A B14 00 14 30Welcome and house notes and course overviewPavel Baranov University College Cork IrelandSebastian Leidel University of Bern SwitzerlandJan Medenbach University of Regensburg GermanyElisabeth Zielonka EMBL Heidelberg GermanyCourtyard A B14 30 15 00Ice Breaking activityCourtyard A B15 00 15 30Coffee BreakCourtyard A B15 30 16 00Introduction Lecture Overview of the course and technology backgroundPavel Baranov University College Cork IrelandSebastian Leidel University of Bern SwitzerlandJan Medenbach University of Regensburg GermanyCourtyard A B16 00 17 00LectureJan Medenbach University of Regensburg GermanyCourtyard A B17 00 18 00LectureSebastian Leidel University of Bern SwitzerlandCourtyard A B18 00 20 00Flash talks by participants speakers and trainersCourtyard A B20 00Bus to ISG HotelATC Entrance20 15 21 30Dinner NetworkingISG Hotel Day 2 Monday 27 March 2023 Time Europe Berlin SessionLocation08 10Bus to EMBL ATCISG Hotel08 30 08 45Laboratory Safety InstructionsCourtyard A B08 45 09 00Overview of the day introduction to practical workCourtyard A B09 00 10 00Practical work preparation of RPFs Native extract preparationLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg GermanyTraining Lab A B10 00 10 30Coffee BreakCourtyard A B10 30 11 30Practical work preparation of RPFs Extract quantification ribonuclease digestion preparation of gradientsLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B11 30 12 00Practical work preparation of RPFs Start of ultracentrifugationLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B12 00 13 00Lunch breakEMBL Canteen13 00 15 30Computer Class Raw Data processing assessment of sequence data quality adaptors removal removal of rRNA and tRNA reads PCR duplicates removal using UMIs read mapping to genomes and transcriptomesPavel Baranov University College Cork IrelandAlla Fedorova University College Cork IrelandJack Tierney University College Cork IrelandOza Zaheed University College Cork Ireland Computer Training Lab15 30 16 00Coffee BreakCourtyard A B16 00 17 00Lecture remote Nicholas Ingolia University of California Berkeley USACourtyard A B17 00 19 00Practical work preparation of RPFsGradient fractionation and RNA preparationLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B19 00 21 00Poster Session Discussion concurrent finger food dinner and drinksATC Helix A Rooftop Lounge21 00Bus to ISG HotelATC Entrance Day 3 Tuesday 28 March 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 15Overview of the dayCourtyard A B09 15 11 00Practical work preparation of RPFsSize selection of RPFs by PAGELeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B11 00 11 30Coffee breakCourtyard A B11 30 12 30Lecture Translation A tug war during viral infectionNoam Stern Ginossar Weizmann Institute of Science IsraelCourtyard A B12 30 13 00Practical work preparation of RPFsGel extraction setup over night incubation Leon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B13 00 14 00Lunch breakEMBL Canteen14 00 16 00Computer Class Quality Assessments Analysis of read mapping across different functional regions read length distribution and triplet periodicity metagen profiles for the assessment of global translationPavel Baranov University College Cork IrelandAlla Fedorova University College Cork IrelandJack Tierney University College Cork IrelandOza Zaheed University College Cork Ireland Computer Training Lab16 00 16 30Coffee breakCourtyard A B16 30 17 30Lecture remote Rachel Green Johns Hopkins University School of Medicine USACourtyard A B17 30 19 00Interactive discussion round Responsible conduct of research sources of experimental artifacts the technology in different species what are the key quality controls parameter space for optimizationCourtyard A B19 00 21 00Poster Session Discussion concurrent finger food dinner and drinksATC Helix A Rooftop Lounge21 00Bus to ISG HotelATC Entrance Day 4 Wednesday 29 March 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 15Overview of the dayCourtyard A B09 15 10 45Practical work Library Preparation Dephosphorylation linker ligationLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B10 45 11 15Coffee breakCourtyard A B11 15 13 15Computer Class Goal oriented data analysis Differential gene expression detection of translated ORFs translational pauses codon specific decoding ratesPavel Baranov University College Cork IrelandAlla Fedorova University College Cork IrelandJack Tierney University College Cork IrelandOza Zaheed University College Cork Ireland Computer Training Lab13 15 14 15Lunch breakEMBL Canteen14 15 15 15Lecture Junk translation translation of junk and translation that does not make proteinsPavel Baranov University College Cork IrelandCourtyard A B15 15 16 15LectureVladimir Benes EMBL Heidelberg GermanyCourtyard A B16 15 16 45Bus downtownATC Entrance16 45 18 45Guided tour of Heidelberg free time downtown18 45 21 15Course dinner Day 5 Thursday 30 March 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 15Overview of the dayCourtyard A B09 15 11 15Practical work Library preparationsubtractive hybridization 1st purification solid phase extraction reverse transcriptionLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B11 15 11 45Coffee breakCourtyard A B11 45 13 15Practical Work Library preparation2nd purification solid phase extraction circularization of RT productLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B13 15 14 15Lunch breakEMBL Canteen14 15 15 15Guided tour of the EMBL genomics core facility Genecore Genecore15 15 16 15Practical Work Library preparation3rd purification solid phase extraction pre amplification PCRLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B16 15 16 45Coffee breakCourtyard A B16 45 17 45Lecture remote Anne Willis MRC Toxicology UKCourtyard A B17 45 18 15Practical Work Library preparation purification of PCR productLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B18 15 19 15DinnerEMBL Canteen19 15 20 45Discussion round Responsible conduct of research protocol optimization the technology in different model organisms future applicationsCourtyard A B20 45Bus to ISG HotelATC Entrance Day 6 Friday 31 March 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 15Overview of the dayCourtyard A B09 15 10 15Lecture Translation dynamics and protein folding Marina Rodnina MPI Biophysical Chemistry GermanyCourtyard A B10 15 10 45Coffee breakCourtyard A B10 45 11 30Practical Work Library preparation Scouting PCR preparation of gelsLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B11 30 13 00Computer Class The use of public data resources riboSeq Org and beyondPavel Baranov University College Cork IrelandAlla Fedorova University College Cork IrelandJack Tierney University College Cork IrelandOza Zaheed University College Cork Ireland Computer Training Lab13 00 14 00Lunch breakEMBL Canteen14 00 15 30Discussion round Data analyses artifactsCourtyard A B15 30 16 00Practical Work Library preparationAnalysis of PCR products by PAGELeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B16 00 16 30Coffee breakCourtyard A B16 30 18 00Practical Work Library preparation Analysis of PCR products by PAGE continued final discussion on library preparationLeon Kleemann University of Bern Switzerland Sebastian Leidel University of Bern Switzerland Jan Medenbach University of Regensburg Germany Andreas Meindl University of Regensburg Germany Elisabeth Zielonka EMBL Heidelberg Germany Training Lab A B18 00 19 00Open discussion Responsible conduct of research data analysis bottlenecks and artifacts data management FAIR principle user defined questionsCourtyard A B19 00Bus to ISG HotelATC Entrance19 15 21 15Dinner and networkingISG Hotel Day 7 Saturday 1 April 2023 Time Europe Berlin SessionLocation08 40Bus to EMBL ATCISG Hotel09 00 09 15Overview of the dayCourtyard A B09 15 10 15Lecture Ribosome profiling in single cellsMichael VanInsberghe Hubrecht Institute KNAWCourtyard A B10 15 10 45Coffee breakComputer Training Lab10 45 11 45Computer Class Datamining competition I Identifying evidence of non standard translation mechanisms student presentations of results Pavel Baranov University College Cork IrelandAlla Fedorova University College Cork IrelandJack Tierney University College Cork IrelandOza Zaheed University College Cork Ireland Computer Training Lab11 45 12 45Lunch breakEMBL Canteen12 45 15 15Computer Class Datamining competition II Identifying evidence of non standard translation mechanisms student presentations of results Pavel Baranov University College Cork IrelandAlla Fedorova University College Cork IrelandJack Tierney University College Cork IrelandOza Zaheed University College Cork Ireland Computer Training Lab15 15 16 15Open discussion and feedbackCourtyard A B16 15End of course bus to main stationATC Entrance Practical information Registration fees and motivation letter The course is limited to 18 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of 26 March to 1 April 2023 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG but that you will be required to pay an additional cost of 31 EUR per night for a single room This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partners Event sponsors Event supporters Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Pavel Baranov, Sebastian Leidel, Jan Medenbach, Elisabeth Zielonka

23 March 2023

Development of a virtual Rheumatoid Arthritis synovial fibroblast for large-scale dynamic analysis and efficient drug-target identification

Description Rheumatoid arthritis RA is a complex systemic autoimmune disease that primarily affects the lining of the synovial joints and involves an intricate interplay among genotype and environmental triggers Early RA starts with the infiltration of the synovial compartment by leukocytes Then the synovial fluid is inundated with pro inflammatory mediators inducing an inflammatory cascade characterised by fibroblast like synoviocytes FLS interactions with cells of the innate and adaptive immune system Cytokines are key mediators whereas drugs inhibiting these cytokines lead to RA therapies Unfortunately 40 of patients fail to respond to therapy Recently many studies have shown that RA FLS activation and the subsequent joint damage they perpetuate are associated with an altered metabolism that may be therapeutically targetable Thus RA FLS directed therapies could become a complementary approach to immune directed therapies I will present our efforts to construct a virtual RA FLS and develop a computational method to simulate large scale coupled logical and metabolic models using Boolean and constraint based modelling The digital RA FLS can be used to predict intervention points for minimising the sustained inflammation bone erosion and cartilage destruction and identify druggable metabolic switches that could help us reprogram these cells to acquire an anti inflammatory phenotype About the speaker Dr Anna Niarakis is an Associate Professor HDR at UEVE Paris Saclay affiliated with GenHotel European Research Laboratory for Rheumatoid Arthritis Genopole She holds a 3 year delegation for research at INRIA in the group Lifeware She has a broad scientific background in Biochemistry Biology and Pharmaceutical Technology and post doctoral studies in Computational Systems Biology Bioinformatics with expertise in complex human diseases She is a co leader of the Disease Maps consortium an active member of CoLoMoTo Consortium for Logical Modelling Tools and a former coordinator of SysMod Systems Modelling...

Anna Niarakis

22 March 2023

Single-cell and spatial omics technologies in plant science

Description Recent technological advances in single cell and spatial omics have revolutionised how we study biology by enabling researchers to see what used to be hidden behind the heterogeneity within the tissue Such technologies have been readily applied to study plants recently This webinar will showcase the application of single cell multiomics transcriptome and epigenome and spatial transcriptomics in plant research focusing on the development of a plant cell atlas and the understanding of plant microbe interactions...

Tatsuya Nobori

21 March 2023

Discover drug targets with Europe PMC Machine Learning Dataset and Open Targets

Description This webinar introduces the Europe PMC human annotated full text corpus for Gene Proteins Diseases and Organisms and highlights how it has been used to train machine learning models for systematic identification and prioritisation of potential therapeutic drugs by the Open Targets Platform This webinar will explain how to access and reuse the annotated corpus as an open community resource and provide an overview of the Open Targets Platform Europe PMC is an open access life science database of journal articles and preprints containing over 41 million abstracts and 8 7 million full text articles Open Targets Platform is an innovative public private partnership that uses human genetics and genomics data for systematic drug target identification and prioritisation Speakers Santosh Tirunagari is a Senior Machine Learning Developer at EMBL EBI with a PhD in Computer Science from the University of Surrey In 2018 Santosh was recognised with the prestigious Outstanding AI post doc research award from CogX The focus of his research is machine learning applied to problems of predictive analytics data driven modelling feature extraction and natural language processing Helena Cornu is the Communications Lead for Open Targets In this role she is responsible for both internal and external communications including running the Open Targets social media accounts writing and commissioning content for the blog and external outreach events She is always looking for opportunities to collaborate so please don t hesitate to get in touch Annalisa Buniello is the Product Manager for Open Targets In her role she oversees development and delivery of the Open Targets bioinformatics resources whilst liaising with users and stakeholders to ensure the products meet their needs...

21 March - 30 March 2023

Exploring human genetic variation

Description Do you want to learn more about genetic variation Are you aware of the resources available for finding viewing and exploring variant data Are you trying to link variant data to phenotypes This four day workshop will demonstrate resources and bioinformatics tools available at EMBL EBI and the Wellcome Sanger Institute that will aid understanding of human genetic variation During the first three days you will learn how to browse retrieve and use human genetic variation data via talks demos and tutorials You will then be provided with exercises to work through the resources on your own with remote trainer support available if needed and provided space to meet other participants if you wish to do so We will meet again on 30 March for a Q A session and discussion about any questions or issues that occurred while working on the materials provided Virtual course Participants will learn via a mix of live talks demos hands on exercises and trainer Q A sessions Practical experience will be developed through homework activities with remote trainer support Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Participants will need to be available between the hours of 09 30 15 30 GMT each day of the course from 21 23 March 2023 and from 09 30 12 00 BST on 30 March 2023 Trainers will be available to assist answer questions and provide further explanations during these times...

Juanita Riveros

15 March 2023

Applying mathematical modelling to biological problems in plant science

Description This webinar will give an overview of the ways in which mathematical models closely integrated with experimental data can be used to give new insights into biological problems We will discuss models for various biological processes and problems at different spatial resolutions and timescales from subcellular to whole plants We will also describe the challenges in integrating models and experimental data and suggest strategies for successful interdisciplinary collaborations...

Rea Laila Antoniou-Kourounioti, John Fozard

14 March - 16 March 2023

Open Virtual Ensembl REST API Workshop

Description Work with Ensembl to master the Ensembl REST API and flexibly access genome wide data such as genes variants regulatory features homologues and alignments...

Aleena Mushtaq

12 March - 17 March 2023

Extracellular vesicles: from biology to biomedical applications

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview A rapidly increasing number of researchers aim to purify and identify extracellular vesicles and many methodologies to isolate and analyse these vesicles are available and have been implemented This course will cover the basics possibilities and limitations of different purification and characterisation techniques and will address strategies to understand their role in biomedical applications Audience This course is intended for PhD students and Postdoctoral researchers who are interested in learning how to work with extracellular vesicles and know more about their biomedical applications Modules resources Extracellular vesicles continuous and discontinuous density gradient ultracentrifugation ultrafiltration techniques bead capture and precipitation techniques size exclusion chromatography SEC Extracellular vesicles characterisation Immunoblot and electron microscopy fluorescent labeling quantitative and qualitative analysis by flow cytometry nanoparticle tracking analysis in vivo imaging proteomic and transcriptomic analysis of EV Extracellular vesicles composition lipidomics proteomics transcriptomics Extracellular vesicles and function molecular players for extracellular vesicle biogenesis extracellular vesicle targeting to cells extracellular vesicles as diagnostics and or therapeutics in pathophysiology Learning outcomes In this course we intend to make PhD students and post doctoral researchers familiar with good practice guidelines and methods for purification and identification of extracellular vesicles with practical sessions included What past participants say about the course This course was very informative and covers all the major aspects of EV research It addresses questions of what level of quality is required for good publications but also offers relevant approaches towards analysing data and critical thinking in the EV field Whether you are taking your first steps in this field or more experienced this course applies to you Dr Berglind Eva Benediktsd ttir University of Iceland Iceland My research is focused on understanding the role of exosomes in the progression of glioblastoma While working on exosome mediated regulation of angiogenesis in glioblastoma I found significant difficulties in getting a pure population of exosomes as it is often contaminated with other biomolecules As a result we were in delusion whether the data which we were getting was the effect of exosomes or other biomolecules Fortunately I found the EMBO Practical Course on extracellular vesicles focusing on the isolation and purification of extracellular vesicles which was extremely important for my research work We were trained to use cutting edge research tools for extracellular vesicles and learned bioinformatic analysis of biomolecules that are present in exosomes I also got an opportunity to interact with world leading researchers and discuss my research Abir Mondal National Centre for Cell Science India Speakers Speakers trainers and staff Edit Buz s Semmelweis University Hungary Ana s B cot Institute of Psychiatry and Neuroscience of Paris France Sarah Deville Ghent University Belgium Virtual trainer Olivier De Wever Ghent University Belgium Mario Gimona Paracelsus Medical University Austria Andr G rgens Karolinska Institutet Sweden An Hendrix Ghent University Belgium Maribel Lara Corona Institute of Psychiatry and Neuroscience of Paris France Cecilia L sser University of Gothenburg Sweden Virtual speaker Estefan a Lozano Andr s Utrecht University The Netherlands Suresh Mathivanan La Trobe University Australia Esther Nolte t Hoen Utrecht University The Netherlands Michiel Pegtel Amsterdam UMC The Netherlands Cl udio Pinheiro Ghent University Belgium Johan Swinnen KU Leuven Belgium Guillaume Van Niel Institute of Psychiatry and Neuroscience of Paris France Marca Wauben Utrecht University The Netherlands Scientific organisers An Hendrix Ghent University Belgium Esther Nolte t Hoen Utrecht University The Netherlands Guillaume Van Niel Institute of Psychiatry and Neuroscience of Paris France Course organisers Raili Pall Course and Conference Officer EMBL Heidelberg Germany Swetlana Krez Training Lab Manager EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOEVs Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 12 March 2023 Time Europe Berlin SpeakerLocation16 00 16 30Registration ISG Hotel16 30 17 00Welcome house notesISG Hotel17 00 19 00Flash talks by participants Ice breaker exerciseISG Hotel19 00Buffer dinner NetworkingISG Hotel Day 2 Monday 13 March 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop08 50 09 00Safety instructionsSwetlana Krez EMBL Heidelberg GermanyCourtyard Room A B09 00 09 15 Outline of the dayAn Hendrix Ghent University BelgiumCourtyard Room A B09 15 10 00Lecture Heterogeneity in EV methodsAn Hendrix Ghent University BelgiumCourtyard Room A B 10 00 10 30Coffee break10 30 11 15Lecture Heterogeneity in EV subtypesEdit Buzas Semmelweis University HungaryCourtyard Room A B 11 15 11 45Introduction to practicals andseparation methodsAn Hendrix Ghent University Belgium Courtyard Room A B 11 45 12 45Lunch break EMBL Canteen12 45 13 45Practical 1 Preparation of EVs by differential ultracentrifugationTraining Lab A B 13 45 14 30Lecture Fluorescent labeling of EVsEsther Nolte t Hoen Utrecht University The NetherlandsCourtyard Room A B 14 30 15 30Practical 1 Fluorescent labelingTrainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara CoronaTraining Lab A B 15 30 16 15Lecture EV biogenesisGuillaume Van Niel Institute of Psychiatry and Neuroscience of Paris FranceCourtyard Room A B 16 15 16 45Coffee break16 45 17 30Lecture RNA sorting in EVsEsther Nolte t Hoen Utrecht University The NetherlandsCourtyard Room A B 17 30 19 45Practical 2 EV separation using Optiprep density gradient centrifugationTrainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara CoronaTraining Lab A B19 45 20 45DinnerEMBL canteen20 45Bus from EMBL to ISG hotelEMBL bus stop Day 3 Tuesday 14 March 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG hotel to EMBLISG hotelbus stop09 00 09 15Outline of the dayGuillaume Van Niel Institute of Psychiatry and Neuroscience of Paris France Courtyard Room A B 09 15 10 25 Practical 3 EV separation using size exclusion chromatographyTrainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara CoronaTraining Lab A B 10 25 10 35Practical ONI CHIP demonstration and addition of EVs Training Lab A B 10 35 10 55 Coffee break10 55 12 00 Practical 2 continuation Collect and process fractions from density gradientsTrainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara Corona Training Lab A B 12 00 12 45Lecture Quantitative and qualitative EV analysis by flow cytometryMarca Wauben Utrecht University The Netherlands Virtual Speaker Courtyard Room A B 12 45 13 45Lunch breakEMBL Canteen13 45 14 30Lecture Single EV analysisAndr G rgens Karolinska Institutet SwedenCourtyard Room A B 14 30 15 45 Practical 4 Particle analysis rotation 1 Trainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara CoronaTraining Lab A B15 45 16 15 Coffee break16 15 17 30 Practical 4 continuation Particle analysis rotation 2 Trainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara CoronaTraining Lab A B17 30 18 45Practical 4 continuation Particle analysis rotation 3 Trainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara CoronaTraining Lab A B18 45 19 30 Tapas dinner ATC Foyer 19 30 21 30Poster session I ODD numbers with drinksATC Foyer21 30Bus from EMBL to ISG hotelEMBL bus stop Day 4 Wednesday 15 March 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 09 15Outline of the dayEsther Nolte t Hoen Utrecht University The NetherlandsCourtyard Room A B 09 15 10 15Practical 8 Data Analysis in 3 groups Trainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara Corona Guillaume Van NielCourtyard Room A B Flexlab A B Seminar room ATC B1110 15 10 45Coffee break 10 45 11 45Lecture EV characterization by transmission electron microscopy and western blot analysis Guillaume Van Niel Institute of Psychiatry and Neuroscience of Paris France Courtyard Room A B 11 45 12 00Intro to practical session Guillaume Van Niel Institute of Psychiatry and Neuroscience of Paris France Courtyard Room A B 12 00 12 45Group activity Tour of electron microscopy core facility with Q A session12 45 13 45Lunch breakEMBL Canteen13 45 17 15Practical sessions 5 6 7 in parallel with flexible coffee break Group 1 EM Prep Maribel Lara CoronaGroup 2 EM remote Guillaume Van NielGroup 3 EV Track An Hendrix Cl udio Pinheiro Sarah Deville virtual Training Lab A B EM Facility Courtyard Room A B Group 1 EM Prep Maribel Lara CoronaGroup 2 EM remote Guillaume Van NielGroup 3 EV Track An Hendrix Cl udio Pinheiro Sarah Deville virtual Training Lab A B EM Facility Courtyard Room A B Group 1 EM Prep Maribel Lara CoronaGroup 2 EM remote Guillaume Van NielGroup 3 EV Track An Hendrix Cl udio Pinheiro Sarah Deville virtual Training Lab A B EM Facility Courtyard Room A B 17 15 18 15Q A SessionCourtyard Room A B 18 15 19 00Pizza dinnerATC Foyer19 00 21 00Poster session II EVEN numbers with drinksATC Foyer21 00Bus from EMBL to ISG hotelEMBL bus stop Day 5 Thursday 16 March 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG hotel to EMBLISG hotel bus stop09 00 09 15Outline of the dayEsther Nolte t Hoen Utrecht University The Netherlands Courtyard Room A B 09 15 10 00Lecture Impact of pre analytical factors on EV separation Cecilia L sser University of Gothenburg Sweden Virtual Speaker Courtyard Room A B 10 00 11 15Practical 8 Data Analysis in 3 groups Trainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara Corona Guillaume Van NielCourtyard Room A B Flexlab A B Seminar room ATC B1111 15 11 45Coffee break11 45 12 45Practical 8 continuation Data Analysis in 3 groups Trainers An Hendrix Esther Nolte t Hoen Ana s B cot Cl udio Pinheiro Estefania Lozano Andr s Maribel Lara Corona Guillaume Van NielCourtyard Room A B Flexlab A B Seminar room ATC B1112 45 12 55Group photo12 55 13 45Lunch break EMBL Canteen13 45 15 45Practical 8 continuation Presentation data analysis and discussionCourtyard Room A B 15 45 16 15Coffee break16 15 17 00Lecture Functional EV analysis in vivoMichiel Pegtel Amsterdam UMC The NetherlandsCourtyard Room A B 17 00Bus from EMBL to ISG HotelEMBL bus stopFree evening Day 6 Friday 17 March 2023 Time Europe Berlin SpeakerLocation08 40Bus from ISG hotel to EMBLISG hotelbus stop09 00 09 15 Outline of the dayAn Hendrix Ghent University BelgiumCourtyard RoomA B 09 15 10 00Lecture TranscriptomicsCl udio Pinheiro Ghent University BelgiumCourtyard Room A B 10 00 10 45Lecture Separation of EVs from different biofluidsOlivier De Wever Ghent University BelgiumCourtyard Room A B 10 45 11 15Coffee break11 15 12 00Lecture ProteomicsSuresh Mathivanan La Trobe University AustraliaCourtyard Room A B 12 00 13 00Lunch breakEMBL Canteen13 00 15 30Practical 9 Practical BioinformaticsSuresh Mathivanan La Trobe University AustraliaComputer Training Lab15 30 16 00Coffee break16 00 16 45Lecture LipidomicsJohan Swinnen KU Leuven BelgiumCourtyard Room A B 16 45 17 30Lecture Clinical applicationMario Gimona Paracelsus Medical University AustriaCourtyard Room A B 17 30 18 30 Meet the speakers sessionCourtyard Room A B ATC Foyer 18 30 19 00Wrap up sessionCourtyard Room A B 19 00Bus from EMBL to Neckarm nzplatz via ISG Hotel EMBL bus stop19 45Course dinner downtown Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of Sunday 12 March to Saturday 18 March 6 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 31 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Participants need to bring their own laptops which will be used to remotely access EMBL virtual machines with pre installed software You will need admin rights to install the software required to access the virtual machines If you do not have admin rights please contact your technical support team in advance to make sure the software can be installed If you have a non standard HDMI port other than type A you need to bring an adaptor Keyboard and PC mouse are available for use with a standard USB port If you have a different port type such as USB C you will need to bring your own Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event partners Event sponsors Event supporters Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

An Hendrix, Cecilia Lässer, Esther Noltet Hoen, Guillaume Van Niel

9 March 2023

Supercomputer-based modelling and simulation for advanced biomedical applications

Description In this talk we will show advancements on the usage of supercomputer based modelling and simulation in advanced biomedical applications including tools for creating virtual populations of Virtual Human Twins and Twinoids In particular we will showcase computational achievements on coupled multi scale and multi physics problems to create in silico clinical trials to understand physiology and to improve old and create new and better therapies Regarding the application problems we will present contributions on blood circulatory system cardiac hemodynamics bioprosthetic heart valves implants and valve reparation surgical procedures respiratory fluid mechanics from upper airways down to alveoli inhalers and nebulizers lung models spinal intrathecal fluid mechanics etc About the speaker Mariano V zquez is CTO CSO of the company ELEM Biotech which develops and commercialises supercomputer based applications for the biomedical sector and researcher of the Barcelona Supercomputing Center from which ELEM spun off in 2018 He has a PhD from the Technical University of Catalunya UPC with postdocs in Dassault Aviation and in INRIA Sophia Antipolis in France...

Mariano Vázquez

8 March 2023

Non-invasive phenotyping to quantify the dynamics of plant-environment interaction

Description Genes provide a toolbox by which plants can interact with their spatially and temporally highly dynamic environment The environment of shoots and roots are distinctly different in their spatial and temporal structures State of the art phenotyping allows deep analysis of these interactions using imaging and even tomographic devices above and below ground This webinar will introduce the concept of plant environment interaction in different spatial and temporal domains and will describe some case studies with modern technologies to study these interactions It will also define the ESFRI Plant Phenotyping Research Infrastructure EMPHASIS and the opportunities for accessing these globally unique facilities for deep phenotyping as well as high throughput and field phenotyping...

Ulrich Schurr, Roland Pieruschka, Sven Fahrner

8 March - 11 March 2023

The cellular mechanics of symbiosis

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Symposium overview Host microbe interactions can be positive or negative for both a host organism and its symbiotic microbes Interacting with microbes can allow eukaryotes to acquire crucial functions like nutrient production but interactions can also be pathogenic in nature This cross disciplinary meeting will bring together scientists using cellular molecular ecological physiological and theory based approaches to explore the evolution of intimate species species interactions Our aim is to understand the cellular systems and pathways that drive transitions in symbiotic states for example as partnerships move from pathogenesis to beneficial and back again Session topics Partners in conflict immunity and pathogenesis in symbiosis Partners in less conflict how are symbionts harnessed for benefit Living in on and around others when is a symbiosis a symbiosis Shared lessons across systems commonalities in symbiosis Please see EMBL s COVID 19 safety recommendations if attending the on site event Speakers Michael Brockhurst University of Manchester United Kingdom Amy Buck University of Edinburgh United Kingdom Virtual Speaker Nicole Dubilier Max Planck Institute for Marine Microbiology Germany Annika Guse Ludwig Maximilian University of Munich Germany Hailing Jin University of California Riverside USA Martin Kaltenpoth Max Planck Institute for Chemical Ecology Germany Patrick Keeling University of British Columbia Canada Virtual Speaker Nancy Moran University of Texas at Austin USA Maria Mota Instituto de Medicina Molecular Biomedical Institute Portugal Shaeri Mukherjee University of California San Francisco USA Victoria Orphan California Institute of Technology USA Teresa Pawlowska Cornell University USA Jillian Petersen University of Vienna Austria Toby Spribille University of Alberta Canada Norio Takeshita University of Tsukuba Japan Assaf Vardi Weizmann Institute of Science Israel Virtual Speaker Scientific Organizers Toby Kiers Vrije Universiteit Amsterdam The Netherlands John McCutcheon Arizona State University USA Thomas Richards University of Oxford United Kingdom Conference Organizer Lina Nikolajeva EMBL Heidelberg Germany Programme Got something to say Tweet it EESSymbiosis For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Day 1 Wednesday 8 March 2023 Time Berlin Europe Speaker11 30 13 00Registration Light Refreshments13 00 13 15Opening remarks13 15 14 35Session 1 Partners in conflict immunity and pathogenesis in symbiosisChair John McCutcheon Arizona State University USA13 15 13 40Host plasmodium interaction a tale of symbiosis and pathogenesisMaria Mota Instituto de Medicina Molecular Biomedical Institute Portugal13 40 13 55Short talk The interaction between T rotula and its phycosphere companion A macleodii The story about the three little glass coated diatoms and the bad parasitic bacteriumUria Alcolombri ETH Z rich SwitzerlandNot available on demand13 55 14 10Short talk Bacterial symbionts giant viruses and protists exploring the mutualism parasitism continuumMatthias Horn University of Vienna Austria14 10 14 35Cross kingdom RNA trafficking between plants and fungal pathogensHailing Jin University of California Riverside USANot available on demand14 35 15 20Coffee break Meet the speakers of Day 1Maria Mota Hailing Jin and Shaeri Mukherjee15 20 17 05Session 1 Partners in conflict immunity and pathogenesis in symbiosis continued Chair John McCutcheon Arizona State University USA15 20 15 45Virtual talk RNA in communication new insights into host helminth interactions in the gutAmy Buck University of Edinburgh United KingdomNot available on demand15 45 16 00Short talk Transcription activator like effector protects bacterial endosymbionts from entrapment within fungal hyphaeIngrid Richter Leibniz Institute for Natural Product Research and Infection Biology Jena Germany16 00 16 15Short talk FISHing for more spatial mapping of the tumour microbiomeShraddha Shitut EMBL Heidelberg Germany16 15 16 40Pathogens as cell biology toolsShaeri Mukherjee University of California San Francisco USA16 40 17 00Break17 00 19 00EMBL pub quiz19 00 20 30Dinner20 30 21 30After dinner drinks Day 2 Thursday 9 March 2023 Time Berlin Europe Speaker08 30 09 15Arrival Coffee09 15 10 35Session 2 Partners in less conflict how are symbionts harnessed for benefitChair Toby Kiers Vrije Universiteit Amsterdam the Netherlands09 15 09 40Virtual talk Cui bono When mutualism is not what it seemsPatrick Keeling University of British Columbia CanadaNot available on demand09 40 09 55Short talk Population and comparative genomics uncover the processes impacting strain level variation in marine endosymbiontsRoxanne Beinart University of Rhode Island USA09 55 10 10Short talk Immune like glycan processing facilitates host control of a facultative endosymbiosisBen Jenkins University of Cambridge University of Oxford United Kingdom10 10 10 35The ecology evolution and metabolic mechanisms of a microbial symbiosisMichael Brockhurst University of Manchester United Kingdom10 35 11 20Coffee break Meet the speakers of Day 2Annika Guse Michael Brockhurst and Martin Kaltenpoth11 20 12 40Session 2 Partners in less conflict how are symbionts harnessed for benefit continued Chair Toby Kiers Vrije Universiteit Amsterdam the Netherlands11 20 11 45Evolution ecology and molecular regulation of tyrosine supplementing symbioses in beetlesMartin Kaltenpoth Max Planck Institute for Chemical Ecology GermanyNot available on demand11 45 12 00Short talk A novel symbiosome in an anaerobic single celled eukaryoteJon Jerlstr m Hultqvist Uppsala University Sweden12 00 12 15Short talk Ticks not only vectors of pathogenic bacteria but also beneficiaries of bacterial symbiosisJan Perner Biology Centre CAS Czech Republic12 15 12 40Adaptation to the environment by symbiosis a model systems approachAnnika Guse Ludwig Maximilian University of Munich Germany12 40 14 10Lunch14 10 15 05Session 2 Partners in less conflict how are symbionts harnessed for benefit continued Chair Annika Guse Ludwig Maximilian University of Munich Germany14 10 14 25Short talk Quid pro quo Leaf beetle propagates a phytopathgen in exchange for pupal protectionHassan Salem Max Planck Institute for Biology Germany14 25 14 40Short talk Nutritional rewards can mediate higher level homeostasis in a tightly integrated leafcutter ant fungus cultivar symbiosisJonathan Shik University of Copenhagen Denmark14 40 15 05Virtual talk Partners in crime controlling algal blooms by mutualism and pathogenicity of viruses and bacteria Assaf Vardi Weizmann Institute of Science Israel15 05 15 45Flash talks 1Ellen Cameron 43 Phoebe Cunningham 47 Erbil Gungor 55 Camille Puginier 67 Johana Rotterova 69 Dayana Salas 71 Giovanni Scarinci 73 Daan Speth 79 Taoping Wu 83 Daniel Yee 85 and Linus Matz Zeller 87 15 45 17 30Poster session 1 odd with beer and snacksPoster numbers17 30Free evening18 15 19 45Optional Heidelberg Old Town tour with an English speaking tour guide Day 3 Friday 10 March 2023 Time Berlin Europe Speaker08 30 09 15Arrival Coffee09 15 10 35Session 3 Living in on and around others when is a symbiosis a symbiosis Chair Martin Kaltenpoth Max Planck Institute for Chemical Ecology Germany09 15 09 40Searching for keys to symbiosis between Buchnera and its aphid hostNancy Moran University of Texas at Austin USA09 40 09 55Short talk Sweet and fat symbionts tracking the carbon metabolism of microalgae within a hostAndrea Catacora Grundy Grenoble Alpes University France09 55 10 10Short talk Metabolic compatibility and the rarity of prokaryote endosymbiosesEric Libby Ume University Sweden10 10 10 35400 million years of symbiosis between marine lucinid clams and their intracellular sulfur oxidizing symbiontsJillian Petersen University of Vienna Austria10 35 11 20Coffee break Meet the speakers of Day 3Nancy Moran Jillian Petersen Nicole Dubilier and Toby Spribille11 20 12 40Session 3 Living in on and around others when is a symbiosis a symbiosis continued Chair Martin Kaltenpoth Max Planck Institute for Chemical Ecology Germany11 20 11 45The ins and outs of beneficial associations between marine invertebrates and their chemosynthetic symbiontsNicole Dubilier Max Planck Institute for Marine Microbiology Germany11 45 12 00Short talk Diplonemid protists and a panoply of their bacterial endosymbiontsJulius Lukes Biology Centre CAS Czech Republic12 00 12 15Short talk Evolution of a host derived endosymbiont division machinery in the trypanosomatid Angomonas deaneiAnay Kumar Maurya Heinrich Heine University D sseldorf Germany12 15 12 40Do we really know what lichen symbionts get from each other Toby Spribille University of Alberta Canada12 40 14 10Lunch14 10 15 05Session 3 Living in on and around others when is a symbiosis a symbiosis continued Chair Jillian Petersen University of Vienna Austria14 10 14 35The role of fungal innate immunity in symbioses between fungi and bacteriaTeresa Pawlowska Cornell University USA14 35 14 50Short talk A dynamic epibiont community associated with the bone eating worm OsedaxBalig Panossian Queen Mary University of London United Kingdom14 50 15 05Short talk Integrins promote the specific uptake of dinoflagellate symbionts in coral algal symbiosisSebastian Rupp Ludwig Maximilian University of Munich Germany15 05 15 50Coffee break Meet the speakers of Day 3 4Teresa Pawlowska Victoria Orphan and Norio Takeshita15 50 17 00Session 3 Living in on and around others when is a symbiosis a symbiosis continued Chair Jillian Petersen University of Vienna Austria15 50 16 15Deep sea electric syntrophy powered by methaneVictoria Orphan California Institute of Technology USA16 15 16 30Short talk Fungi and algae the intimacy and diversity of lichen partnershipsKlara Scharnagl University of California Berkeley USA16 30 16 45Short talk A systematic inventory of lichen symbioses using metagenomicsGulnara Tagirdzhanova The Sainsbury Laboratory United Kingdom16 45 17 00Short talk Translation at the end of the endosymbiotic timelineJessica Warren Arizona State University USA17 00 17 30Flash talks 2Erika Corretto 46 Liam Friar 50 Terezia Horvathova 56 Valentina Margarita 60 Om Patange 64 Line Roager 68 Max Emil Sch n 74 Noah Spencer 78 and Shunta Yorimoto 86 17 30 19 00Poster session 2 even with beer and snacksPoster numbers19 00 20 30Conference dinner20 30 22 30Conference party Day 4 Saturday 11 March 2023 Time Berlin Europe Speaker08 30 09 15Arrival Coffee09 15 10 10Session 4 Shared lessons across systems commonalities in symbiosisChair Thomas Richards University of Oxford UK09 15 09 40Mutual bacterial fungal relationship fungal highways let bacteria travel in exchange for thiamineNorio Takeshita University of Tsukuba Japan09 40 09 55Short talk Who s in control The evolution of invertebrate microbiomes is driven by the bacteria not the hostsVittorio Boscaro University of British Columbia Canada09 55 10 10Short talk Placement of bacteria into the cytosol of mammalian cells allows real time analysis of bacterial growth and host responsesChantal Ernst ETH Z rich SwitzerlandNot available on demand10 10 10 55Coffee break 10 55 11 40Session 4 Shared lessons across systems commonalities in symbiosis continued Chair Thomas Richards University of Oxford UK 10 55 11 10Short talk Phagocytosis underpins the biotrophic lifestyle of intracellular parasites in the class Phytomyxea Rhizaria Andrea Garvetto University of Innsbruck AustriaNot available on demand11 10 11 25Short talk Expanding the host range for a fungal endosymbiont through implantation by FluidFMGabriel Giger ETH Z rich Switzerland11 25 11 40Short talk A 450 million year old mechanism of interaction control in arbuscular mycorrhiza symbiosisM lanie Rich LRSV Toulouse FranceNot available on demand11 40 12 00Closing remarks Poster prize12 15Packed lunch and departure12 30Bus to ISG Hotel and hotels downtownOptional Shuttle bus to Frankfurt Airport Terminal 1 Tickets can be purchased during the conference Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 700On site PhD Student 600 On site Industry 900Virtual Academia 200Virtual PhD Student 150Virtual Industry 250 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Lina Nikolajeva for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme EMBO and Gordon and Betty Moore Foundation in the form of both registration fee waivers and travel grants Availability of travel grants is limited to participants attending on site events in Heidelberg and will be indicated during the abstract submission process Both on site and virtual participants can apply for registration fee waivers Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 7 February 2023 in some cases at special rates Please quote the booking code EES23 01 and confirm the exact price of the room with the hotel directly Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Download the bus schedule here The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Bergheimer Str Neckarmuenzplatz Peterskirche ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event sponsor Cell Research Event supporter Media partners EMBO Journal an EMBO Press journal International Union of Biochemistry and Molecular Biology PLOS Biology a PLOS journal FEBS Open Bio a FEBS Press journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Toby Kiers, John McCutcheon, Thomas Richards

7 March 2023

Data submission for genome-wide association studies at the GWAS Catalog

Description The GWAS Catalog is a major repository for full summary statistics from genome wide association studies We encourage authors to submit their data to us to make them accessible and reusable by the wider GWAS community In 2023 we are introducing some improvements to the submission process to enhance the precision and reusability of the data we collect This webinar provides a step by step guide to the submission process including recent changes to the standard summary statistics format...

Elliot Sollis

7 March - 9 March 2023

Open Virtual Ensembl Browser Workshop

Description Work with the Ensembl Outreach team to get to grips with the Ensembl browser accessing gene variation comparative genomics and regulation data and mine these data with BioMart...

Aleena Mushtaq

7 March - 8 March 2023

Introduction to HPC for Life Scientists

Description High performance computing HPC is a fundamental technology used to solve a wide range of scientific research problems Many important challenges in science such as protein folding drug discovery and tumour evolution all depend on simulations models and analyses run on HPC facilities to make progress This course introduces HPC to life science researchers focusing on the aspects that are most important for those new to this technology to understand It will help you judge how HPC can best benefit your research and equip you to go on to successfully and efficiently make use of HPC facilities in future The course will cover basic concepts in HPC hardware software user environments filesystems and programming models It also provides an opportunity to gain hands on practical experience and assistance using an HPC system MARENOSTRUM through examples drawn from the life sciences such as biomolecular simulation GROMACS and multicellular simulations PhysiCell The course is organised and funded by PerMedCoE the HPC Exascale Centre of Excellence in Personalised Medicine https permedcoe eu and BioExcel the Centre of Excellence for Computational Biomolecular Research http bioexcel eu using the HPC infrastructure at the Barcelona Supercomputing Centre This course will take place face to face on the premises of the Universitat Polit cnica de Catalunya BarcelonaTech UPC...

Marta Lloret Llinares

6 March - 10 March 2023

Introduction to multi-omics data integration and visualisation

Description With the increase in the volume of data across the whole spectrum of biology more opportunities as well as challenges have been created to identify novel perspectives and answer questions in life sciences This may also include public domain data which can provide added value to data derived through researcher s own work and inform experimental design This introductory course will highlight the challenges that researchers face in integrating multi omics data sets using biological examples The course will focus on the use of public data resources and open access tools for enabling integrated working with an emphasis on data visualisation This course will not include systems biology modelling or machine learning A major element of this course is a group project where participants will be placed in small groups to work together on a challenge set by trainers from EMBL EBI data resource and research teams This allows people to explore the bioinformatics tools and resources introduced in the course and to apply these to a set problem providing hands on experience of relevance to their own research The group work will culminate in a presentation session involving all participants on the final day of the course giving an opportunity for wider discussion on the benefits and challenges of integrating data You may refer to the previous group projects that were organised for this course in March 2022 Additional information The course fee is inclusive of four nights accommodation and catering including dinner We plan to deliver this course in an in person manner onsite at our training suite at EMBL EBI Hinxton Hybrid options are not currently available Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing Please also note that there are delays in the issuing of visas from the UK Government We encourage you to check if you need a visa and apply in plenty of time before travelling Current waiting times are more than six weeks For more information please visit the UK Government website...

Shereen Pethania

5 March - 10 March 2023

Techniques for mammary gland research

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview The mammary epithelium is a unique organ in that the majority of its development occurs postnatally This combined with ease of experimental access and a stereotypical growth pattern make it an ideal tissue for studying cellular homeostasis branching morphogenesis hormonal effects stem cell biology and breast cancer This theoretical and practical course will present techniques for the dissection and dissociation of different subpopulations of both mouse and human mammary cells including stem progenitor cells It will also include flow cytometry to separate single cell populations for the consequent in vitro mammosphere and 3D cultures and in vivo mouse mammary fat pad clearing and cell transplantation analysis to assess stem cell activity and gene function Audience This course targets PhD students post docs and other scientists entering the field of mammary gland biology and breast cancer or those who wish to complement their knowledge using mouse or human methods Modules resources Introduction to mouse and human mammary gland biology including experimental techniques e g histology mammosphere cultures imaging Fat pad clearing and transplantations mouse demonstration and hands on Mammary gland harvest and Carmine staining mouse demonstration and hands on Mammary gland digestion and 2D 3D culture mouse demonstration and hands on FACS staining analysis mouse and human demonstration and hands on Intraductal injections mouse demonstration and hands on Learning outcomes The participants will learn about the complete workflow for mammary gland studies and gain an understanding about possibilities and limitations of working with mouse and human systems Speakers Keynote speaker Jane Visvader The Walter and Eliza Hall Institute of Medical Research Australia Virtual Speaker Speakers trainers and staff Richard Iggo Bordeaux Institute of Oncology France Martin Jechlinger EMBL Heidelberg and MOLIT Institute Germany Bethan Lloyd Lewis University of Bristol UK Monika L schinger Luxendo Bruker Fluorescence Microscopy Germany Philip Mbonu MOLIT Institute Germany Diana Ordonez EMBL Heidelberg Germany Matthew Smalley Cardiff University UK Virtual Speaker Stefan Terjung EMBL Heidelberg Germany Ren e van Amerongen University of Amsterdam The Netherlands Maria dM Vivanco CIC bioGUNE Center for Cooperative Research in Biosciences Spain Malte Wachsmuth Luxendo Bruker Fluorescence Microscopy Germany Scientific organisers Martin Jechlinger EMBL Heidelberg and MOLIT Institute Germany Ren e van Amerongen University of Amsterdam The Netherlands Maria dM Vivanco CIC bioGUNE Center for Cooperative Research in Biosciences Spain Course organisers Charlotte Courtney Course and Conference Officer EMBL Heidelberg Germany Ernesto de la Cueva Head of Laboratory Animal Resources EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOMammaryGland Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours may be required and if so will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Sunday 5 March 2023 Time Europe Berlin Session and speakersLocation15 30 16 00RegistrationISG Hotel16 00 16 15Welcome and house notesEMBL Course and Conference Office TeamISG Hotel 16 15 17 00Course OverviewMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyISG Hotel 17 00 19 30PresentationsShort talks by participants 4 mins each ISG Hotel19 30 20 30DinnerISG Hotel restaurant20 30 21 00Networking and drinksISG Hotel restaurant Day 2 Monday 6 March 2023 Time Europe Berlin Session and speakersLocation08 40Bus departure from ISG Hotel to EMBL HeidelbergISG Hotel entrance 09 00 09 10Overview of the dayMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyCourtyard Room A B09 10 09 20Introduction to lab safetyEMBL Course and Conference Office TeamCourtyard Room A B09 20 10 00Lecture 1 Introduction to mouse mammarygland techniquesRen e van Amerongen University of Amsterdam The NetherlandsCourtyard Room A B10 00 10 40Lecture 2 Introduction to human mammary glandMar a dM Vivanco CIC bioGUNE SpainCourtyard Room A B10 40 12 40Practical session 1 Demo mammary fat pad clearingRichard Iggo Bordeaux Institute of Oncology FranceRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B12 40 13 40Lunch EMBL Canteen13 40 14 25Lecture 3 FACS introductionMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsCourtyard Room A B14 25 15 55Practical Session 2 Mammary gland harvest for Carmine stain and overnight digestion for FACS 3D cultureRichard Iggo Bordeaux Institute of Oncology FranceRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B15 55 16 10Coffee breakCourtyard Room A B16 10 17 40Practical Session 2 Mammary gland harvest for Carmine stain and overnight digestion continuation Richard Iggo Bordeaux Institute of Oncology FranceRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B17 40 18 10Practical discussion with discussion leader Richard Iggo Bordeaux Institute of Oncology FranceRen e van Amerongen University of Amsterdam The NetherlandsCourtyard Room A B18 10 19 10Organisation of the grant writing exerciseMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyCourtyard Room A B19 10 20 10DinnerEMBL ATC Rooftop Lounge20 10 22 10Poster session 1 odd numbers Helix B near the EMBL ATC Rooftop Lounge22 15Bus departure from EMBL Heidelberg to ISG HotelEMBL ATC Entrance Day 3 Tuesday 7 March 2023 Time Europe Berlin Session and speakersLocation08 40Bus departure from ISG Hotel to EMBL HeidelbergISG Hotel09 00 09 10Overview of the dayMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyCourtyard Room A B09 10 10 25Virtual Lecture 4 Keynote lecture on Stem cells mammary gland development and breast cancerJane Visvader VIRTUAL SPEAKER The Walter and Eliza Hall Institute of Medical Research AustraliaCourtyard Room A B10 25 12 10Practical session 3 Digest organoids to single cells and seeding on 2D Philip Mbonu MOLIT Institute GermanyMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B12 10 13 10LunchEMBL Canteen13 10 13 55Lecture 5 FACS analysis for practicals Mar a dM Vivanco CIC bioGUNE SpainCourtyard Room A B13 55 15 55Practical session 4 Mouse stain for FACS Martin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyDiana Ordonez EMBL Heidelberg GermanyPractical Session 5 Human staining for ALDH and FACS Mar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsTraining Lab A B15 55 16 05Coffee breakCourtyard Room A B16 05 18 05Practical session 4 Mouse stain for FACS continued Martin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyDiana Ordonez EMBL Heidelberg GermanyPractical session 5 Human staining for ALDH and FACS continued Mar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsTraining Lab A B18 05 19 05Lecture 6 MIND intro Richard Iggo Bordeaux Institute of Oncology FranceCourtyard Room A B19 05 19 35Practical discussion with discussion leaderMartin Jechlinger EMBL Heidelberg and MOLIT Institute Germany Mar a dM Vivanco CIC bioGUNE Spain Ren e van Amerongen University of Amsterdam The NetherlandsCourtyard Room A B19 35 20 35DinnerEMBL Canteen20 45Bus departure from EMBL Heidelberg to ISG HotelEMBL ATC Entrance Day 4 Wednesday 8 March 2023 Time Europe Berlin Session and speakersLocation08 40Bus departure from ISG Hotel to EMBL HeidelbergISG Hotel09 00 09 10Overview of the dayMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyCourtyard Room A B09 10 11 10Practical session 6 Seeding 3D culturesPhilip Mbonu MOLIT Institute GermanyMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyPractical session 7 MIND practicals and Mammary gland Carmine processing Richard Iggo Bordeaux Institute of Oncology France Ren e van Amerongen University of Amsterdam The Netherlands Martin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B11 10 11 20Group photoMeet at Courtyard Room A B11 20 13 20Practical session 6 Seeding 3D cultures continued Philip Mbonu MOLIT Institute GermanyMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyPractical session 7 MIND practicals and Mammary gland Carmine processing continued Richard Iggo Bordeaux Institute of Oncology France Ren e van Amerongen University of Amsterdam The Netherlands Martin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B13 20 14 20Lunch EMBL Canteen14 20 14 50Lecture 7 3D cultures Martin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyCourtyard Room A B14 50 15 20Lecture 8 Mammosphere cultures Mar a dM Vivanco CIC bioGUNE SpainCourtyard Room A B15 20 15 50Coffee breakCourtyard Room A B15 50 16 20Practical discussion with discussion leaders Richard Iggo Bordeaux Institute of Oncology France Ren e van Amerongen University of Amsterdam The Netherlands Martin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B16 20 17 20Group activity Group work on grant writingCourtyard Room A B17 20 19 20Poster session 2 even numbers Helix B near the EMBL ATC Rooftop Lounge19 20 20 20DinnerEMBL Canteen20 35Bus departure from EMBL Heidelberg to ISG HotelATC Entrance Day 5 Thursday 9 March 2023 Time Europe Berlin Session and speakersLocation08 40Bus departure from ISG Hotel to EMBL HeidelbergISG Hotel entrance09 10 09 55Lecture 9 Lecture on tumour histology Matt Smalley VIRTUAL SPEAKER Cardiff University UKCourtyard Room A B09 55 11 25Practical session 8 Mounting Carmine Analysing group work on grant writing Ren e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyTraining Lab A B11 25 12 10Lecture 10 Imaging Bethan Lloyd Lewis University of Bristol UKCourtyard Room A B12 10 12 40Lecture 11 Microscopy Stefan Terjung EMBL Heidelberg GermanyCourtyard Room A B12 40 13 10LunchCourtyard Room A B13 10 13 40Lecture 12 SPIM imaging Malte Wachsmuth Bruker and Luxendo GermanyCourtyard Room A B13 40 17 10Practical Session 9 SPIM Malte Wachsmuth Bruker and Luxendo GermanyMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyPractical Session 10 Continuation analysis and discussion Mar a dM Vivanco CIC bioGUNE Spain Richard Iggo Bordeaux Institute of Oncology FranceGroup activity Group work on grant writingALMF facility tourTraining Lab A B13 40 17 10Coffee break available throughout rotationsCourtyard Room A B13 40 17 10Rotations continued Practical Session 9 SPIM Malte Wachsmuth Bruker and Luxendo GermanyMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyPractical Session 10 Continuation analysis and discussion Mar a dM Vivanco CIC bioGUNE Spain Richard Iggo Bordeaux Institute of Oncology FranceGroup activity Group work on grant writingALMF facility tourTraining Lab A B17 10 18 50Presentation of the group projectsCourtyard Room A B18 55 19 05Bus departure from EMBL Heidelberg to ISG HotelEMBL ATC Entrance19 05 19 20Time at ISG Hotel to drop personal items changeISG Hotel19 20Bus to city centreISG Hotel entrance19 45Final course dinnerOskar restaurantTaxis back to the ISG hotel after dinnerCity centre Day 6 Friday 10 March 2023 Time Europe Berlin Session and speakersLocation08 40Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 10Overview of the dayMar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyCourtyard Room A B09 10 10 40Practical Session 11 Analyzing and photographing 3D cultures wrap up carmine staining analysis if needed Mar a dM Vivanco CIC bioGUNE SpainRen e van Amerongen University of Amsterdam The NetherlandsMartin Jechlinger EMBL Heidelberg and MOLIT Institute GermanyRichard Iggo Bordeaux Institute of Oncology FranceTraining Lab A B10 40 11 10Group activity Results of grant writing projectsCourtyard Room A B11 10 12 10Final panel discussion Analysis troubleshooting for projects with trainers wrap upCourtyard Room A B12 10 13 10LunchEMBL Canteen13 30 14 00Bus departure to Heidelberg main train station city centreEMBL ATC Entrance Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel The registration fee includes accommodation for 5 nights checking in 5 March 2023 checking out 10 March 2023 at the ISG Hotel in a single room including breakfast Any additional nights need to be booked and paid for by you to the hotel We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Martin Jechlinger, Renée van Amerongen, María dM Vivanco

2 March 2023

UniProt for proteomics scientists

Description UniProt is a comprehensive expert led publicly available database of protein sequence function and variation information This webinar will give a brief introduction to the UniProt website and then highlight resources available that proteomics scientists or users with large protein datasets may find useful in analysing their data This will encompass our proteomes service how to convert and retrieve ID mappings how to carry out a peptide search and how to visualise new large scale proteomics derived PTM data The webinar will then go on to introduce the UniProt Proteins API which allows researchers to access and download UniProt data alongside large scale genomic proteomics and variation data without needing prior in depth knowledge of programmatic languages Data is available for download and querying in a range of formats including XML FASTA and PEFF The API multi query search functions will be demonstrated and useful features such as searching entries by peptide and the new functionality of searching for proteomic peptides and modifications will be explained The UniProt Proteins API is available at www ebi ac uk proteins api doc...

Emily Bowler-Barnett

1 March 2023

Exploring plant genes and genomes with Ensembl

Description The Ensembl Plants genome browser provides visualisation and analysis of integrated genomic data including genes variants comparative genomics and gene regulation for over 100 plant species and cultivars This webinar will provide an overview of the range of available data and through Ensembl Plants and use examples to explore the various interfaces for visualising and exporting data...

Guy Naamati

1 March - 4 March 2023

2025 TEMPLATE_Symposium_Onsite_with_Virtual

Description OverviewSpeakersProgrammePractical informationSponsorsAboutMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Symposium overview SHORT summary about the event and why delegates should attend could also be merged with the aims Please send final summary to marketing team for proofing before publishing Session topics Topic 1 Topic 2 Topic 3 Topic 4 Topic 5 Topic 6 What past participants say about the Symposium Quote Name affiliation Country only if applicable Speakers Keynote speakers Speakers Scientific organisers Conference organisers Programme Are you on social media Post using xxx Event hashtag and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 1 Day Month Year Day 2 Day Month Year Day 3 Day Month Year Day 4 Day Month Year Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia XXXOn site PhD Student XXXOn site Industry XXXOn site Journal Editor XXXVirtual Academia XXXVirtual PhD Student XXXVirtual Industry XXX Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Name of CO for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee As further changes in our events are possible you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until Day Month Year in some cases at special rates Please email the hotel directly quoting the booking code XXX20 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergHotel MonptiHotel Bayrischer Hof InterCity Hotel HeidelbergPremier Inn Heidelberg CityB B HotelISG Hotel Staycity Aparthotel HeidelbergExzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Hotel Staycity Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Hotel Premier Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarmuenzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page Onsite information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen Sie How are you Wie gehts I m fine thanks And you Mir geht es gut danke Und dir Ihnen What is your nameWie hei en Sie formal Wie hei t du informal My name is Ich hei e Do you speak English Sprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Wei wein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks English Ich brauche einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for onsite events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de About EMBO EMBL Symposia promote scientific communication and collaboration in the European research area They provide scientists with a platform to discuss and exchange ideas on forward looking topics and new developments in the life sciences Topics emphasise upcoming developments and the interdisciplinary nature of related fields Jointly funded and organised by EMBO and EMBL and complementary to their respective courses workshops and conference programmes the symposia promote scientific communication and collaboration All symposia are held in the EMBL Advanced Training Centre ATC in Heidelberg Germany or virtually Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

1 March - 4 March 2023

2025 TEMPLATE_Conference_Onsite_with_Virtual

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kitPreliminary Programme TEST Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Registration is not yet open for this event If you are interested in receiving more information please register your interest Conference overview SHORT summary about the event and why delegates should attend could also be merged with the aims Please send final summary to marketing team for proofing before publishing Session topics Topic 1 Topic 2 Topic 3 Topic 4 Topic 5 Topic 6 What past participants say about the conference Quote Name affiliation Country only if applicable Speakers Keynote speakers Speakers Scientific organisers Conference organiser Programme Are you on social media Post using xxx Event hashtag and don t forget to tag EMBLEvents Please note that the programme is subject to change Some speakers may need to join virtually to give their talk For registered participants recorded talks will be accessible on demand for 4 weeks after the end of the event unless indicated otherwise Day 1 Day Month Year Day 2 Day Month Year Day 3 Day Month Year Day 4 Day Month Year Practical information Registration fees and abstract submission On site registration fees include admission conference materials meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia XXXOn site PhD Student XXXOn site Industry XXXOn site Journal Editors XXXVirtual Academia XXXVirtual PhD Student XXXVirtual Industry XXX Editors from scientific journals are allowed to attend at a reduced rate but asked to contribute to the conference in return by taking part in meet the editors sessions or other planned activities within the programme A letter to support your visa application will be issued on request once payment of the registration fee is confirmed We recommend that you book your visa appointment as soon as possible to avoid any delay with your visa application Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Name of CO for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of registration fee waivers travel grants and childcare grants Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant There is the possibility to apply for a childcare grant to offset child care costs incurred by participants speakers and organisers when attending a conference Eligible costs include but are not limited to fees for a baby sitter or child care facility and travel costs for a caregiver Please note that priority will be given to early stage researchers In order to apply for this grant you must be registered by the abstract submission deadline There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of registration fee waivers and travel grants during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection for registration fee waivers and travel grants is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Childcare grants will be allocated in the same timeframe 6 8 weeks before the event start date Please note that priority will be given to early stage researchers Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and travel Accommodation is not included in the conference registration fee The hotels below have rooms on hold for participants until 4 weeks before check in date in some cases at special rates Please email the hotel directly quoting the booking code XXX24 01 to confirm the exact price of the room Hotel AnlageHotel ibis HeidelbergHotel MonptiHotel Bayrischer Hof InterCity Hotel HeidelbergPremier Inn Heidelberg City ZentrumB B HotelISG Hotel Staycity Aparthotel HeidelbergThe Heidelberg Exzellenz HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergHilton HeidelbergMeininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Travel information For travel information please see here If you are travelling to the conference within Germany then you are eligible for the Deutsche Bahn Event Ticket called the Veranstaltungsticket in German This will result in a lower ticket price if your travel distance to Heidelberg is more than 100 km You need to provide proof of your event attendance when purchasing the ticket For more information in English see here or in German see here You can book your ticket here Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn City Zentrum Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop Hilton Hotel Kurf rsten Anlage 1 ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For more information about accommodation and travel please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing EMBL merchandise products presented in the glass display in the registration area please email the EMBL shop to place an order or get in contact with your Course Organiser Kindly note the EMBL shop is only open upon request and all purchases must be made in cash Euros only Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available on campus using the EMBL Events network and the event specific password which will be provided on site The eduroam network secure worldwide roaming access service developed for the international research and education community is also available Lost and found Lost and Found items are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photos If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help to print your boarding pass train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer meditation and yoga located on level E0 behind the Auditorium Please be respectful of others using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf Wiedersehen formal Tsch ss informal Good morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryEs tut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke Und Dir Ihnen What is your nameWie hei en Sie formal Wie hei t Du informal My name isIch hei e Do you speak EnglishSprechen Sie englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m vegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishIch brauche einen Arzt der englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during the event and for 4 weeks afterwards Please note at the request of individual speakers some talks are not recorded Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9PPT Slide 16 9 Leaderboard 728 90 Preliminary Programme TEST The programme is still in development and will be announced before the conference Please note that times vary per day usually starting around 09 00 Europe Berlin and finishing in the evening after a dinner and a social activity party For now take a look at the list of confirmed speakers and their proposed talks Confirmed speakerPreliminary title of talkJohn University of Meh Country The effects of Bla on Bleh Trisha Awesome College Country Why pineapple on pizza is good for your microbiome Moritz Institute of Molecular Foot Research Country Why we should all buy socks Lara University of Tardiness CountryTitle to be announced soonFrieda Science Club Country Neurons are the new fidget spinners...

26 February - 3 March 2023

Analysis and integration of transcriptome and proteome data

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview Systems biology is a still expanding field of research aiming to understand at the molecular level how cells tissues and organisms operate in their biological context Among the key technologies driving this forward are next generation sequencing and proteomics as they provide powerful means to determine global expression levels of genes and proteins Both fields have matured to a degree that they have now become accessible to researchers in many areas of biology During this course participants will gain theoretical insight in the structure of sequencing and proteomic data and they will receive training in data analysis for the annotation quantification and statistical analysis of gene and protein expression using various computational tools In addition training will be provided in the use of Cytoscape to derive biological insights from the integration of both data types Audience This course is targeted at biologists and biochemists who are starting to be involved in both next generation sequencing and mass spectrometry based proteomics but who are not experts in these fields Modules resources Principles of mRNA quantification Principles of protein identification and quantification Principles and application of bioinformatic tools for mining of transcriptome and proteome data Data integration by Cytoscape Learning outcomes The aim of this practical course is to provide insight in techniques that are frequently used for transcriptome and proteome analysis and to provide hands on experience turning primary data into information that can be used for further biological interpretation To achieve these goals participants will gain insight in the basic principles of gene expression analysis RNAseq data quantification and differential expression analysis protein identification and quantification and they will be trained in the use of software tools to analyse sequencing and proteomic data SearchGUI PeptideShaker MaxQuant In addition the course will provide insight in the complementarity of transcriptome and proteome data by their integrative analysis via Cytoscape What past participants say about the course This course organised by EMBL is an excellent opportunity for wet lab biologists to gain skills and understand the necessary bioinformatic background for both designing experiments and performing data analysis Katarzyna Tutak Institute of Human Genetics Polish Academy of Science Speakers Speakers trainers and staff Vladimir Benes EMBL Heidelberg Germany Hyungwon Choi National University of Singapore Singapore Daria Fijalkowska Ghent University Belgium Jeroen Krijgsveld German Cancer Research Centre DKFZ Germany Manjeet Kumar EMBL Heidelberg Germany Jonathan Landry EMBL Heidelberg Germany Lennart Martens VIB University of Ghent Belgium Gerben Menschaert University of Ghent Belgium Scooter Morris University of California San Francisco USA Santhust EMBL Heidelberg Germany Mikhail Savitski EMBL Heidelberg Germany Jan Provaznik EMBL Heidelberg Germany Kristina Roucova Univerzita Karlova Czech Republic Scientific organisers Vladimir Benes EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Jeroen Krijgsveld German Cancer Research Centre DKFZ Germany Lennart Martens VIB University of Ghent Belgium Course organisers Maria Mercedes Bacadare Goitia Course and Conference Manager EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it EMBLDataIntegration Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change The preliminary programme below is a draft and is subject to change Day 1 Sunday 26 February 2023 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 09 15Arrival welcome and safety introductionsCourtyard room09 15 11 00RNA seq cool but is it that simple Vladimir Benes EMBL Heidelberg GermanyCourtyard room11 00 11 30Coffee breakATC Foyer11 30 12 30RNAseq Reads to genesJonathan Landry EMBL Heidelberg GermanyJan Provaznik EMBL Hiedleberg GermanyKristina Roucova Univerzita Karlova Czech RepublicCourtyard room12 30 13 30LunchEMBL Canteen13 30 16 00Practical From Reads to Genes Bulk and single cell Jonathan Landry EMBL Heidelberg GermanyJan Provaznik EMBL Hiedleberg GermanyKristina Roucova Univerzita Karlova Czech RepublicComputer Training Lab16 00 16 30Coffee breakComputer Training Lab16 30 18 00Q A on RNAseq and scRNAseqComputer Training Lab18 00Departure to ISG HotelATC entrance18 30DinnerISG Hotel Day 2 Monday 27 February 2023 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00Flash talk presentationsComputer Training Lab10 00 12 30Practical theory Differential expression analysis Jonathan Landry EMBL Heidelberg GermanyJan Provaznik EMBL Hiedleberg GermanyKristina Roucova Univerzita Karlova Czech Republicwith flexible coffee breakComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Practical session Ribosome profilingGerben Menschaert University of Ghent BelgiumComputer Training Lab16 00 16 30Coffee breakComputer Training Lab16 30 18 30Lecture practicals Ribosome profilingGerben Menschaert University of Ghent BelgiumComputer Training Lab18 30 19 40DinnerEMBL Canteen19 40Departure to ISG HotelATC entrance Day 3 Tuesday 28 February 2023 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 11 00Introduction to ProteomicsJeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab11 00 11 30Coffee breakComputer Training Lab11 30 12 30Lecture Quantitative proteomics TMTMikhail Savitski EMBL Heidelberg GermanyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 15 00Lecture Bioinformatics for proteomicsLennart Martens University of Ghent BelgiumComputer Training Lab15 00 16 00Practical Session Turning data into information peptide and protein identification database searchingLennart Martens University of Ghent BelgiumComputer Training Lab16 00 16 30Coffee BreakComputer Training Lab16 30 18 00Q A to Bioinformatics for proteomicsLennart Martens University of Ghent BelgiumComputer Training Lab18 00 19 00DinnerEMBL Canteen19 00Departure to ISG HotelATC entrance Day 4 Wednesday 1 March 2023 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00Lecture Quantitative proteomics SILAC and other MS1 based approachesJeroen Krijgsveld German Cancer Research Centre DKFZ GermanyComputer Training Lab10 00 10 30Coffee break10 30 12 00Lecture Introduction to MaxQuant analysis of MS dataDaria Fijalkowska University of Ghent BelgiumComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Practical Session Proteomics data interpretationDaria Fijalkowska University of Ghent BelgiumComputer Training Lab14 30 16 15Lecture P values and multiple testing correctionHyungwon Choi National University of Singapore SingaporeComputer Training Lab16 15 Free afternoon16 15Departure to ISG Hotel and downtown Day 5 Thursday 2 March 2023 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00Q A to Bioinformatic tools for data comparison and integrationJohn Scooter Morris University of California San Francisco USAComputer Training Lab10 00 10 30Coffee break10 30 12 30Practical Introduction to CytoscapeJohn Scooter Morris University of California San Francisco USAManjeet Kumar EMBL Heidelberg GermanySanthust EMBL Heidelberg GermanyComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Practical Introduction to CytoscapeJohn Scooter Morris University of California San Francisco USAManjeet Kumar EMBL Heidelberg GermanySanthust EMBL Heidelberg GermanyComputer Training Lab16 00 16 30Coffee breakComputer Training Lab16 30 17 45Lecture and Practical Enrichment analysisJohn Scooter Morris University of California San Francisco USAManjeet Kumar EMBL Heidelberg GermanySanthust EMBL Heidelberg GermanyComputer Training Lab17 45Departure to ISG Hotel and downtownATC entrance18 30Downtown Dinner Day 6 Friday 3 March 2023 Time Europe Berlin SpeakerLocation08 40 09 00Bus from ISG Hotel to EMBL ATC entranceISG Hotel bus stop09 00 10 00Application talk Network oriented integrative multi omics analysis of tissues and fluids case studies in cancer and cardiovascular diseasesHyungwon Choi National University of Singapore SingaporeComputer Training Lab10 00 10 30Coffee break10 00 12 30Practical Session Data integrationJohn Scooter Morris University of California San Francisco USAComputer Training Lab12 30 13 30LunchEMBL Canteen13 30 16 00Practical Session Data integrationJohn Scooter Morris University of California San Francisco USAManjeet Kumar EMBL Heidelberg GermanySanthust EMBL Heidelberg Germanywith flexible coffee breakComputer Training Lab16 00 16 30Course wrap up and farewellComputer Training Lab16 30Departure to Train Station and DowntownATC entrance Practical information Registration fees and motivation letter The course is limited to 24 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 690PhD Student 690Industry 1200 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 6 nights 25 Feb 3 March 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code PRO23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Vladimir Benes, Raffaele Calogero, Jeroen Krijgsveld, Lennart Martens

22 February 2023

Accessing variant data at the European Variation Archive

Description The European Variation Archive EVA is a primary open repository for archiving accessioning and distributing genome variation including single nucleotide variants short insertions and deletions indels and larger structural variants SVs in any species This webinar will demonstrate how to access the latest EVA release consisting of submitted variants clustered into RS IDs It will also provide an overview of the recent updates to this data including what species have had their variant data remapped and how we annotate remapped variant data...

Baron Koylass

22 February 2023

Interrogating the effect of enzyme kinetics on metabolism using differentiable constraint-based models

Description Metabolic models are typically characterised by a large number of parameters Traditionally metabolic control analysis has been applied to differential equation based models to investigate the sensitivity of predictions to parameters A corresponding theory for constraint based metabolic models is lacking due to their formulation as optimization problems In this webinar we will show several applications of differentiating optimal solutions of constraint based models and show how it connects to classic metabolic control analysis Efficient differentiation of constraint based models can be used to calculate the sensitivities of predicted reaction fluxes and enzyme concentrations to turnover number parameters in an enzyme constrained metabolic model of Escherichia coli Further it unlocks the ability to use gradient information for parameter estimation We demonstrate this by improving genome wide the state of the art turnover number estimates for E coli Finally this technique can be used to differentiate the optimal solution of a model incorporating both thermodynamic and kinetic rate equations The predicted growth rate sensitivity to metabolite concentrations was shown to align well against experimentally measured metabolome changes subject to gene knockouts About the speaker St Elmo Wilken completed his undergraduate degree in Chemical Engineering at the University of Pretoria His Ph D at the University of California Santa Barbara leveraged both computational and wet lab aspects to investigate and understand the metabolism of anaerobic gut fungi His current postdoc at the Institute of Quantitative and Theoretical Biology at the Heinrich Heine University in D sseldorf is focused on using quantitative models to elucidate the contribution of metabolism to the stability and composition of microbial consortia He partnered with PerMedCoE researchers including Dr Miroslav Kratochvil to develop a way to differentiate constraint based models to conduct sensitivity analyses efficiently...

St. Elmo Wilken

20 February - 24 February 2023

Introduction to RNA-seq and functional interpretation

Description Gain an introduction to the technology data analysis tools and resources used in RNA sequencing and transcriptomics The content will provide a broad overview of the subject area and introduce participants to basic analysis of transcriptomics data using the command line It will also highlight key public data repositories and methodologies that can be used to start the biological interpretation of expression data Topics will be delivered using a mixture of lectures practical exercises and open discussions Computational work during the course will use small example data sets and there will be no opportunity to analyse personal data In person course We plan to deliver this course in person in our training suite at EMBL EBI Hinxton Please be aware that we are continually evaluating the ongoing pandemic situation and as such may need to change the format of courses at short notice Your safety is paramount to us you can read our COVID guidance policy for more information All information is correct at time of publishing...

Sophie Spencer

12 February - 17 February 2023

In situ CLEM at room temperature and in cryo

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Course overview Correlative Light and Electron Microscopy CLEM allows precise localisation of an event of interest within cells and tissues During this course we will focus on a specific method that has been developed at EMBL that enables the localisation of fluorescent proteins with high accuracy at the ultrastructural level The course will cover both the theory and practicals of high precision CLEM as well as opportunities to discuss their research with CLEM experts and receive practical and troubleshooting advice Audience This course is intended for scientists with experience in EM who want to further develop their skills in high accuracy correlated microscopy Modules resources The course will combine lectures and hands on practical work covering all steps in the work flow including cryogenic sample preparation ultramicroscopy image registration and electron tomography Learning outcomes Participants will gain hands on experience with the CLEM methods and learn tips from the people who developed the methods Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Speakers Speakers trainers and staff Ori Avinoam Weizmann Institute of Science Israel Johanna Bischof EMBL Heidelberg Germany Mandy B rmel EMBL Heidelberg Germany Petr Chlanda University of Heidelberg Germany Kar Ho Herman Fung EMBL Heidelberg Germany Helmut Gnaegi Diatome Ltd Switzerland Alexandra Elli ZEISS Research Microscopy Solutions Germany Martin Fritsch EMBL Heidelberg Germany Michael Hons EMBL Grenoble France Pedro Machado Oxford Instruments NanoAnalysis UK Julia Mahamid EMBL Heidelberg Germany Rachel Mellwig EMBL Heidelberg Germany Giulia Mizzon Heidelberg University Hospital Germany Viola Oorschot EMBL Heidelberg Germany Perrine Paul Gilloteaux University of Nantes France Virginia Pierini EMBL Heidelberg Germany Andreia Pinto Leica Microsystems Germany Paolo Ronchi EMBL Heidelberg Germany Anna Sartori Rupp Institut Pasteur France Martin Schorb EMBL Heidelberg Germany Christian Tischer EMBL Heidelberg Germany Zhengyi Yang EMBL Heidelberg Germany Ievgeniia Zagoriy EMBL Heidelberg Germany Scientific Organisers Ori Avinoam Weizmann Institute of Science Israel Rachel Mellwig EMBL Heidelberg Germany Martin Schorb EMBL Heidelberg Germany Course Organisers Lea Hohmann EMBL Heidelberg Germany Irena Provaznikova EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOCLEM Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 12 February 2023 Time Europe Berlin SpeakerLocation14 00 14 30RegistrationISG Hotel 14 30 15 00Welcome and house notes and course overviewISG Hotel 15 00 16 00EMBO Young Investigator Lecture How to choose your CLEM approach Ori Avinoam Weizmann Institute of Science IsraelISG Hotel 16 00 16 30Coffee breakISG Hotel 16 30 19 00Flash talks by speakers trainer and participantsISG Hotel 19 00 Open endDinnerISG Hotel Day 2 13 February 2023 Time Europe Berlin SpeakerLocation09 00 09 15Safety briefing Courtyard Room A B 09 15 10 15Keynote lecture History of Cryo CLEMAnna Sartori Rupp Institut Pasteur FranceCourtyard Room A B10 15 10 30Coffee breakCourtyard Room A B 10 30 11 30Lecture Strategies to culture cells for cryoEM Ievgeniia Zagoriy EMBL Heidelberg GermanyCourtyard Room A B11 30 12 15Lecture Technical aspects of the RT and Cryo CLEM workflowMandy Boermel EMBL Heidelberg Germany Martin Schorb EMBL Heidelberg GermanyCourtyard Room A B 12 15 13 15LunchATC Foyer13 15 18 30Practical Sample preparation RT and cryo parallel sessions for 3 sub groups Training Lab A B18 30 19 40DinnerEMBL Canteen Day 3 14 February 2023 Time Europe Berlin SpeakerLocation09 00 10 00Lecture Tips and tricks to adapt on section CLEM to diverse biological questionsPaolo Ronchi EMBL Heidelberg GermanyCourtyard Room A B 10 00 11 00Lecture Tricks and pitfalls in ultramicrotomyHelmut Gnaegi Diatome Ltd SwitzerlandCourtyard Room A B 11 00 11 15Coffee breakCourtyard Room A B 11 15 12 15Lecture Site Specific Cryo FIB PreparationJulia Mahamid EMBL Heidelberg GermanyCourtyard Room A B 12 15 13 00LunchEMBL Canteen13 00 19 00Practicals RT sectioning light microscopy at RT and cryo parallel sessions for 4 sub groups Training Lab A B19 00 20 00DinnerEMBL Canteen Day 4 15 February 2023 Time Europe Berlin SpeakerLocation09 00 10 15Computer practical SerialEM hands on with Remote TEM sessionMartin Schorb EMBL Heidelberg GermanyComputer Training Lab10 15 10 30Coffee breakComputer Training Lab10 30 12 00Computer practical SerialEM hands onMartin Schorb EMBL Heidelberg GermanyComputer Training Lab12 00 13 00LunchEMBL Canteen13 00 14 30Introduction Computer practical Icy and ec CLEM Perrine Paul Gilloteaux University of Nantes FranceComputer Training Lab14 30 15 00Coffee breakComputer Training Lab15 00 16 30Computer practical Icy and ec CLEMPerrine Paul Gilloteaux University of Nantes FranceComputer Training Lab16 30 17 00Wrap up of first round of practicals that have introduced the entire workflow Q AComputer Training Lab17 00 open endSocial Event Guided city tour and dinner in old town HeidelbergDowntown Heidelberg Day 5 16 February 2023 Time Europe Berlin SpeakerLocation09 00 10 00Keynote Lecture Cryo CLEM to study virusesPetr Chlanda University of Heidelberg GermanyCourtyard Room A B 10 00 10 30Coffee breakCourtyard Room A B 10 30 11 00Lecture Practical considerations for 3D cryo CLEMHerman Fung EMBL Heidelberg GermanyCourtyard Room A B 11 00 11 30Lecture EasyGrid Advancing cryo EM sample preparationMichael Hons EMBL Grenoble FranceCourtyard Room A B11 30 12 15Lecture Volume CLEM and 3DCLEMPedro Machado Oxford Instruments NanoAnalysis UKPaolo Ronchi EMBL Heidelberg GermanyCourtyard Room A B 12 15 13 00LunchEMBL Canteen13 00 19 00Practicals In depth PRACTICALS on specific topics based on students selection subgroups Training Lab A B 19 00 20 00DinnerEMBL Canteen Day 6 17 February 2023 Time Europe Berlin SpeakerLocation09 00 09 45Lecture Multimodal image data handling visualization etc Christian Tischer EMBL Heidelberg GermanyCourtyard Room A B 09 45 10 30Roundtable discussion on open questions students explain implementations for their own projectsCourtyard Room A B 10 30 11 00Coffee breakCourtyard Room A B 11 00 12 30Discussion Call for Help Discussion on specific questions concerning the participants projectsCourtyard Room A B 12 30 12 45Lecture Introduction to relevant networks EuroBioImaging access to imaging resources EMBL IC Aastha Mathur EMBL Heidelberg GermanyVirginia Pierini EMBL Heidelberg GermanyCourtyard Room A B 12 45 13 00Wrap up FeedbackCourtyard Room A B 13 00 13 15Packed lunch FarewellCourtyard Room A B Practical information Registration fees and motivation letter The course is limited to 20 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1200 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Accommodation has been pre booked for you at the ISG Hotel for the default dates of 12 to 17 February 5 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG In case you would like to have a single room please let us know and please note that you will be required to pay an additional cost of 31 per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings The bus schedule can be found here Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Event supporter Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Ori Avinoam, Rachel Mellwig, Martin Schorb

10 February 2023

Accessing human disease and protein variant information in UniProtKB

Description UniProt knowledgebase UniProtKB supports biomedical research by providing a comprehensive high quality and freely accessible resource of protein sequence and functional information This webinar will provide an overview on how to access human disease and protein variant information available in UniProtKB The annotation of protein molecular function involvement in human disease as well as disease associated variant positions variant characterisation and their impact on protein structure and function will be outlined Protein variant information will be presented in tabular view or in the feature viewer and shown how the feature viewer facilitates visualising the impact of variants on protein features and 3D structure Cross links to human specific databases and other relevant resources will be briefly discussed In addition it will be demonstrated how to access and download human variation datasets available in UniProtKB We hope that this introduction will give you an understanding of how to access disease related protein data in UniProtKB and how to make use of the different protein molecular data to analyse protein variant impact on protein function and structure...

Yvonne Lussi

9 February 2023

The case of data reuse: ethical, legal, and societal issues in international genomic data access and sharing

Description Health data collected in cohort studies are valuable sources for knowledge generation and the advance of biomedical research However the use of these data for research projects beyond the initial purpose raises several ethical legal and societal questions regarding the sensitivity of genomic data sourced from vulnerable and ethnic groups such as African genetic data and material The webinar addresses these challenges regarding reuse of health genomic data in CINECA from the ELSI perspective and FAIR principles and highlights GDPR provisions and their institutional sources of interpretation national laws the corresponding legal ethical and social science literature as well as outcomes from stakeholder engagement workshops with patient representatives African researchers and CINECA technical experts The webinar provides ethical and legal recommendations that take societal implications into account for data access to European Canadian and African cohorts and responsible sharing mainly on four key areas 1 Engagement and benefit sharing as prerequisites for data sharing 2 Informed consent and reuse of data 3 Safeguards and respect for privacy and 4 Further uses and data access The webinar concludes with an outlook on upcoming ELSI developments regarding data reuse synthetic data and artificial intelligence AI...

Melanie Goisauf, Emmanuelle Rial-Sebbag

8 February - 11 February 2023

In situ structural biology: from cryo-EM to multi-scale modelling

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Workshop overview There is an increasing awareness that mechanistic structural information on molecular machines is ideally generated within the context of intact cells in order to fully grasp how they function in a complex native environment Recent technological advances have nurtured the development of such in situ structural biology approaches in several disciplines including cryo EM mass spectrometry super resolution microscopy NMR computational modelling and others This conference will bring together experts and early stage researchers from the separate fields to provide a platform for structural biology within the cellular context to stimulate discussions about how to meaningfully integrate data from different methods to define what types of biological questions can already be addressed using in situ structural biology and which might be approached in the future NEW your chance to attend a job fair and have a 1 1 meeting to discuss job opportunities Further details to be announced Session topics In situ cryo EM Super resolution light microscopy Modelling across scales Emerging technologies Advances in instrumentation Proteomics Imaging across scales What past participants say about the conference The conference was fantastic with an amazing list of speakers As an early career researcher I found these events very inspirational and broadening for research opportunities later Kamila Kamuda University College London UK I immensely benefited from the workshop organized by EMBL through talks of so many brilliant scientists who had explained the fast evolving technique to capture the whole cell structure at the near atomic resolution Samar Ballabha Mohapatra Indian Institute of Technology India Speakers Keynote speakers Rommie Amaro University of California San Diego USA Juergen Plitzko Max Planck Institute of Biochemistry Germany Speakers Francisco Balzarotti Research Institute of Molecular Pathology IMP Austria Peter Dahlberg SLAC National Accelerator Laboratory USA Ben Engel University of Basel Switzerland Ana Garc a S ez University of Cologne Germany Trey Ideker University of California San Diego USA Janet Iwasa University of Utah USA Melike Lakadamyali University of Pennsylvania USA Fan Liu Leibniz Forschungsinstitut for Molecular Pharmacology FMP Germany Bronwyn Lucas UMass Chan Medical School USA Holger M ller University of California Berkeley USA Weria Pezeshkian Niels Bohr Institute Denmark Ilaria Piazza Max Delbr ck Center for Molecular Medicine Germany Susanne Rafelski Allen Institute for Cell Science USA Dina Schneidman Duhovny The Hebrew University of Jerusalem Israel Philipp Selenko Weizmann Institute of Science Israel Ilaria Testa SciLifeLab Sweden Aubrey Weigel HHMI Janelia Research USA Peijun Zhang University of Oxford UK Scientific organisers Martin Beck Max Planck Institute of Biophysics Germany Jan Kosinski EMBL Hamburg Germany Julia Mahamid EMBL Heidelberg Germany Suliana Manley EPFL Switzerland Conference organiser Chris Stocks Course and Conference Team Lead EMBL Heidelberg Programme Got something to say Tweet it EMBOinsitu Please note that due to the ongoing pandemic situation some speakers may need to join virtually to give their talk and the programme is subject to change Recorded talks will be accessible on demand for 2 weeks after the end of the event Day 1 Wednesday 8 February 2023 Time Europe Berlin Title 11 30 13 00 Registration and light refreshments13 00 13 15Opening remarks by scientific organisers13 15 14 00KeynoteRommie Amaro University of California USAIntroduced by Jan Kosiski 14 00 17 00Session 1 in situ cryo EMSession chair Julia Mahamid14 00 14 25In situ multi scale structural analysis of virus infection by cellular cryo tomographyPeijun Zhang University of Oxford UK Live stream only 14 25 14 40Cryo electron tomography and deep learning denoising reveal native chromatin landscapes of interphase nucleiMikhail Elfsov IGBMC France14 40 14 55Plate like guanine biocrystals form via templated nucleation of crystal leaflets on preassembled scaffoldsZohar Eyal Weizmann Institute of Science Israel14 55 15 40Coffee Break and Meet the speakers15 40 16 05Visualizing ribosome biogenesis in cells with 2DTMBronwyn Lucas University of Massachusetts USA16 05 16 20Enabling discovery with in cell cryo ET alphaFold identification of a novel translocation complexRasmus Jensen EMBL Heidelberg Germany16 20 16 35Structural insight into the Ebola virus nucleocapsid assembly cascade by in cell cryo correlative light and electron microscopyMelina Vallbracht Heidelberg University Hospital Germany16 35 17 00Exploring photosynthesis and carbon fixation across scales with cryo electron tomographyBen Engel University of Basel Switzerland17 00 17 40Flash talks 46 G lberk Bayraktar 48 Tiana Behr 52 Daksh Daksh 60 Chinenye Ekemezie 74 Andreja Kezar 77 Matthew Lycas 82 Evangelia Nathanail 84 Alexander Rau 85 Karolina Roganowicz 89 Simon Schaefer 94 Eva Maria Soriano Jerez 95 Marie Christin Spindler 97 Reiya Taniguchi 102 Renjing Wang 103 Helena Watson 106 Davide Zabeo 110 Michael Zimmermann 17 40 19 00Dinner in Canteen19 00 20 30Welcome reception and tour of Imaging Centre Day 2 Thursday 9 February 2023 Time Europe Berlin Title 08 15 09 15 Arrival09 15 12 00Session 2 Advances in super resolution light microscopySession chair Suliana Manley09 15 09 40Visualizing the inner life of cells with super resolution microscopyMelike Lakadamyali University of Pennsylvania USA09 40 09 554Pi STORM visualization of nuclear pore complex architectureMark Bates Institute for Nanophotonics Germany Live stream only 09 55 10 10Visualization of loop extrusion by nanoscale 3D DNA tracing in single human cellsKai Beckwith EMBL Heidelberg Germany10 10 10 40Coffee Break and Meet the speakers10 40 11 05Accessing nanoscale structure and dynamics with lightFrancisco Balzarotti Research Institute of Molecular Pathology Austria Live stream only 11 05 11 20Toward correlative cryogenic super resolution light and electron microscopyHisham Mazal Max Planck Institute Germany11 20 11 35Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosisAline Tschanz EMBL Heidelberg Germany11 35 12 00Bringing light to mitochondrial apoptosisAna Garcia Saez University of Cologne Germany Live stream only 12 00 13 30Lunch including job fair 13 30 16 30Session 3 Modeling across scalesSession chair Rommie Amaro13 30 13 55Integrative structure modeling of protein complexes in the age of deep learning Dina Schneidman Duhovny The Hebrew University of Jerusalem Israel13 55 14 10Towards visual proteomics In situ detection of macromolecular complexes by high resolution template matchingSergio Cuz Leon Max Planck Institute of Biophysics Germany14 10 14 25Combining computation and microscopy to reveal mechanisms in bacterial transport machinesAngela Kirykowicz University of Cambridge UK14 25 15 10Coffee break and meet the speakers15 10 15 35Computational microscopy of biomembrane shapesWeria Pezeshkian Niels Bohr Institute Denmark15 35 15 50Predicting lipid protein interactions in the age of integrative structural biologyStefano Vanni University of Fribourg Switzerland15 50 16 05Validation of integrative structures in PDB Dev based on SAXS CX MS and 3DEM dataArthur Zalevsky University of California USA16 05 16 30Animating Data Rich Molecular Mechanisms Janet Iwasa University of Utah USA16 30 17 05Flash talks 54 Sofia De Felice 55 Takahiro Deguchi 67 Jan Philipp Kreysing 69 Nazia Hussain 79 Johannes Rudolph 87 Jenny Sachweh 101 Christian Tueting 109 Liv Zimmermann 47 Paul Becker 49 Harald Bernhard 51 Cristina Capitanio 93 Deniz Daviran 57 Joe Dobbs 61 Bronwen Foster 73 Mukthi Iyer17 00 18 30Poster Session 1 odd with beer and snacksThe poster listing can be found here18 30 20 00Dinner in Canteen20 00 22 00Pub Quiz and social drinks Day 3 Friday 10 February 2023 Time Europe Berlin Title08 15 09 15 Arrival09 15 12 00Session 4 Emerging technologiesSession chair Martin Beck09 15 09 40What in cell NMR can teach us about intracellular protein structures and dynamics Phil Selenko Weizmann Institute of Science Israel09 40 09 55Live cell imaging and integrative modeling to explore the functionality of protein assembliesAltair Chinchilla Hernandez Pompeu Fabra University Spain09 55 10 10Cryo EM snapshots of eukaryotic membrane proteins in native lipid bilayer nanodiscsKevin Janson Martin Luther University Halle Wittenberg Germany10 10 10 40Coffee Break and meet the speakers10 40 11 05Integrated intracellular organization and its variations in human iPS cells Susanne Rafelski Allen Institute for Cell Science11 05 11 20Linking cellular ultrastructure to gene expression with correlative cryo ET scRNA seqAndre Schwarz Max Planck Institute for Brain Research Germany11 20 11 35Exploiting OMVs for the in situ characterization of bacterial envelope proteinsJohannes Thoma University of Gothenburg Sweden live stream only 11 35 12 00Protein structures in context with proteome wide biophysicsIlaria Piazza Max Delbr ck Center for Molecular Medicine Germany Live stream only 12 00 13 30Lunch13 30 16 45Session 5 InstrumentationSession chair Jurgen Plitzko13 30 14 15Keynote The long and winding road to in situ structural biology with cryo ETJuergen Plitzko Max Planck Institute of Biochemistry GermanyIntroduced by Julia Mahamid14 15 14 30Plasma FIB milling for the determination of structures in situCasper Berger Rosalind Franklin Institute UK14 30 14 45Cryo FIB milling and cryo ET of vertically trapped dividing E coli bacteriaVictoria Hale MRC Laboratory of Molecular Biology UK14 45 15 30Coffee Break and Meet the speakers15 30 15 55Dynamics of molecules at the nanoscale with photo switching Ilaria Testa SciLifeLab Sweden remote talk 15 55 16 20Super resolved cryogenic correlative light and electron microscopy Specific labelling with cellular contextPeter Dahlberg Stanford USA16 20 16 45Laser phase plate Advancing beyond proof of conceptHolger M ller University of California Berkeley USA16 45 17 20Flash talks 44 Milan Aleksic 56 Natalie Diepenhorst 58 Wioleta Dudka 62 Herman Fung 66 Miguel Hernandez Gonzalez 76 Sven Klumpe 68 Neil Mcdonald 83 Alessandro Passera 86 Max Ruwolt 88 Veijo Salo 92 Ioannis Skalidis 96 Frosina Stojanovska 100 Zuzana Trebichalsk 104 Yu Le Wu 108 Christian Zimmerli17 20 18 45Poster Session 2 even with beer and snacksThe poster listing can be found here18 45 20 15CONFERENCE DINNER in the canteen20 15 22 45Live music Day 4 Saturday 11 February 2023 Time Europe Berlin Title08 15 09 15 Arrival09 15 12 30Session 6 Across scalesSession chair Philipp Selenko09 15 09 40Developing structural interactomics and its application in cell biologyFan Liu Leibniz Forschungsinstitut for Molecular Pharmacology Germany09 40 09 55Integrative structural studies of thyroid homeostasis a first look into cellular and organoids organisationFrancesca Coscia Human Technopole Italy09 55 10 20Towards automated segmentation in volume electron microscopyAubrey Weigel Institute of Genetics and Molecular and Cellular Biology USA remote talk 10 20 10 50Coffee Break and Meet the speakers10 50 11 05Bacterial nano compartments their function in metal homeostasis and role in the cellular response mechanisms against stressC lia Maria Rom o Universidade Nova de Lisboa Portugal11 05 11 20How influenza A virus solves the nuclear escape roomDaniel Ziemianowicz EMBL Hamburg Germany11 20 11 45Building a mind for cancerTrey Ideker University of California USA11 45 12 30Round table discussion12 30 12 45Closing remarks and poster prize Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks livestreamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 175Virtual PhD Student 125Virtual Industry 225 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for a reduced press rate or in some cases for complimentary registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Christopher Stocks for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only participants registering to attend the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After registration you can submit your abstract via a separate link that will be provided in the email confirmation Alternatively you can access the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Abstract body The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest should be lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory fields are First Name Last Name Organisation Name Affiliation or Company Country and Email Kindly mark only one author in the role of First Author and please don t forget to indicate who will be the Presenter Please enter your co authors correctly via the system by adding accounts together with their organisation institute Do not copy paste them into the body of the abstract text as they will not be indexed in the abstract book Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline For detailed instructions on how to submit a conference abstract follow the instructions provided in this video Please check our FAQs pages for further information on how to submit an abstract Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants These are available for on site participants at EMBL Conferences and EMBO EMBL Symposia and for on site and virtual participants at EMBO Workshops We are currently working on securing funding for all virtual participants and ask that you please apply for financial assistance for both on site and virtual participation Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel to an on site event airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Workshop up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Workshop Registration fees are only covered for EMBO Workshops The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Workshops only For EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference Eligible costs include fees for a baby sitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application On site participants You may apply for financial assistance when submitting your abstract In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Virtual participants If you are attending virtually you can apply for financial assistance in the submission portal by the abstract deadline Read the instructions on how to apply for financial assistance Only submissions for financial assistance will be accepted Presentation abstracts cannot be submitted here and will be declined In your application you will be asked to summarise your current work answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreSteffi s Hostel HeidelbergExzellenz Hotel Meininger HeidelbergHotel Vier Jahreszeiten HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage Opposite Main Train Station Premier Inn Kurf rsten Anlage 23 Leonardo Hotel Heidelberg City Center Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel Im Eichwald 19 View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Download the conference bus schedule here If you miss the bus you can call a taxi at 49 6221 302030 Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting points Do not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions HelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie gehts I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDankesch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talks Video library of the recorded talks during and after the event Facility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Event sponsors DECTRIS AG Single Particle LLC Event supporters Media partners EMBO reports an EMBO Press journal International Union of Biochemistry and Molecular Biology Open Biology a Royal Society journal Journal of Structural Biology an Elsevier journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9 Leaderboard 728 90...

Martin Beck, Jan Kosinski, Julia Mahamid, Suliana Manley

6 February - 10 February 2023

Single-cell RNA-seq analysis using Galaxy

Description This course utilises Galaxy pipelines an online open access resource that allows even the most computer phobic bench scientists to analyse their biological data Participants will be guided through the droplet based scRNA seq analysis pipelines from raw reads to trajectories Please note that although participants will not be able to use their own data during the course practicals there will be ample time to discuss their research and ideas with both course participants and trainers As part of this participants will present posters on their research topics Virtual course This course will now be held virtually it was previously advertised as an on site course Hybrid options are not currently available We reserve the right to change the format of this course or cancel it due to the ongoing coronavirus pandemic Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and asynchronous communication via Slack Pre recorded material may be provided before the course starts that participants will need to watch read or work through to gain the most out of the actual training event In the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Trainers will be available to assist answer questions and provide further explanations during the course...

Jane Reynolds

1 February 2023

Exploring reproducible and reusable systems biology models with BioModels

Description This webinar will give an overview of BioModels a popular repository of curated systems biology models This will include a recent update on model content and features It will also briefly introduce BioModels Parameters a sub resource within BioModels that provides model parts It will show how modellers can easily find access and reuse interoperable systems biology models We will also discuss how curation efforts in BioModels tackle the reproducibility crisis...

Rahuman Sheriff Malik Sheriff

31 January 2023

Federated analysis for polygenic risk score calculations

Description Polygenic risk scores PRS provide an estimate of an individual s disposition to a trait or complex disease which are calculated as the sum of the risk alleles weighted by the effect size estimate of the genome wide association study data on the phenotype PRS scores help in understanding the shared aetiology of certain traits and also in risk prediction and prevention of certain diseases As a part of the CINECA project we have been working on the development of a demonstrator of federated genetic analyses utilising a computational pipeline for PRS analysis We have implemented this workflow using Nextflow a modular and reproducible workflow manager that can be deployed and autoscaled to many different working environments including Slurm based clusters and Kubernetes deployed using AWS amongst other computing environments In this webinar we will provide an overview of this PRS pipeline utilising the CINECA UK1 synthetic dataset derived from the 1000 genomes project as a demonstrator As part of the work we will further extend the demonstrator to other datasets and GWAS workflows and integrate it to be run in a federated setting utilising the GA4GH guidelines on using Beacons for data discovery along with AAI passports for data access authorisation and deployments The CINECA Common Infrastructure for National Cohorts in Europe Canada and Africa project aims to develop a federated cloud enabled infrastructure to make population scale genomic and biomolecular data accessible across international borders to accelerate research and improve the health of individuals across continents About the speakers Will Rayner is the head of the Data and Analytics group at the Institute of Translational Genomics in the Computational Health Department at Helmholtz Munich He is interested in all aspects of data management and data privacy and has been leading the CINECA WP4 PRS use case Anshika Chowdhary is a Data informatician at the Institute of translational genomics in Helmholtz Zentrum Munich She has been working on the development of the workflows in WP4 of the PRS use case and analysis of the eQTL catalog on the datasets at HMGU...

Will Rayner, Anshika Chowdhary

31 January - 1 February 2023

EuroFAANG GENE-SWitCH workshop: utilisation of GENE-SWitCH data in Ensembl and beyond

Description This one and a half day workshop will provide detailed training on the utilisation of the wealth of data generated by the EuroFAANG GENE SWitCH project that is delivering new underpinning knowledge for pig and chicken agriculture The workshop will primarily focus on the comprehensive and integrated annotation of the chicken and pig genomes by the Ensembl Genome Browser The course will also include a deeper dive from the Ensembl analysis teams into gene annotation and regulation and demonstrations of the specific analyses and genomic prediction models generated by GENE SWitCH researchers...

Peter Harrison

26 January - 27 January 2023

Amity University EMBL-EBI workshop 2023

Description Amity University EMBL EBI workshop 2023...

Ben Moore

25 January 2023

Accessing fine-grained Molecular Interactions data with IntAct

Description This webinar will provide an introduction to molecular interactions and how to find these through the molecular interaction database IntAct We will demonstrate examples of how you can search for interaction data using advanced filter options how to create molecular interaction networks using our network viewer based on Cytoscape js and how to download the data for further analysis We will show how to access mutation data affecting the outcome of molecular interactions We will also provide a brief overview of two other resources PSICQUIC and IMEx that integrate molecular interactions from several sources...

Kalpana Panneerselvam

25 January 2023

Data-driven modelling of intercellular interactions in the tumour microenvironment

Description Monocyte derived macrophages help maintain tissue homeostasis and defend the organism against pathogens In tumours recent studies have uncovered complex macrophage populations including tumour associated macrophages which support tumorigenesis through cancer hallmarks such as immunosuppression angiogenesis or matrix remodelling In the case of chronic lymphocytic leukaemia these macrophages are known as nurse like cells and they protect leukemic cells from spontaneous apoptosis contributing to their chemoresistance We propose an agent based model of monocyte differentiation into nurse like cells upon contact with leukemic B cells in vitro We performed patient specific model calibrations using cultures of peripheral blood mononuclear cells from patients Using our model we were able to reproduce temporal survival dynamics of cancer cells in a patient specific manner and to identify patient groups related to distinct macrophage phenotypes Our results show a potentially important role of phagocytosis in the polarization process of nurse like cells and in promoting cancer cells enhanced survival About the speaker Dr Vera Pancaldi was trained as a physicist and soon found her way in systems and computational biology Since 2018 she leads a computational biology team at the Cancer Research Center of Toulouse CRCT working on modelling cancer and its interactions with the immune system Her main current focus is understanding the relationship between genome architecture and heterogeneity at various levels and relating heterogeneity in the phenotype of tumour infiltrating immune cells to patient s response to immunotherapy...

Vera Pancaldi

24 January - 27 January 2023

Computing skills for reproducible research: data carpentry

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview The missing step between data collection and research progress is a lack of training for researchers in crucial skills for effectively managing and analysing large amounts of data This hands on workshop teaches researchers the fundamental data skills they need to conduct their work and provides high quality domain specific training covering the full lifecycle of data driven research The domain specific approach allows participants to tailor the data content and tools to reflect the specific data and analysis needs of different areas Audience The course is aimed at graduate students and other researchers in the life sciences who would like to learn good practices in project and data organisation and computational data analysis with R The course is ideally suited to students without prior experience in computational research but some familiarity with working with tabular data on a computer is welcome Modules resources Data organisation and cleaning Versioning with Git Introduction to R Data analysis and visualisation in R Data analysis with applications to genomics Learning outcomes How to organise data and some practices for more effective data handling To effectively clean and format data and automatically track any changes To use R to handle filter and summarise tabular data To use the split apply combine concept for data analysis To visualise the results of these analyses in R using the ggplot2 library To apply all of the concepts in an exploratory analysis of a typical biological dataset What past participants say about the course The best course to take first steps in data analysis I learned a lot and wholeheartedly recommend it to everyone learning programming for scientific purposes Magdalena Ziemianska Maj Institute of Pharmacology Polish Academy of Sciences Poland I have to thank all the instructors and organisers that made this course a success Very intuitive and everyone was very helpful leaving no doubts unanswered I highly recommend this course to anyone who wants to start learning R Soraia Vieira University of vora Portugal Speakers Speakers trainers and staff Renato Alves EMBL Heidelberg Germany Gaurav Diwan University of Heidelberg Germany Florian Huber EMBL Heidelberg Germany Lisanna Paladin EMBL Heidelberg Germany Fotis Psomopoulos Center for Research and Technology Hellas CERTH Greece Supriya Khedkar EMBL Heidelberg Germany Eleonora Mastrorilli EMBL Heidelberg Germany Scientific organisers Renato Alves EMBL Heidelberg Germany Lisanna Paladin EMBL Heidelberg Germany Fotis Psomopoulos Center for Research and Technology Hellas CERTH Greece Christian Schudoma EMBL Heidelberg Germany Course organisers Inna B sselmann Course and Conference Manager EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it with EMBLDataCarpentry On Monday 16 January at 11 am CET participants will be required to attend a virtual onboarding and software installation check via eCampus The course will continue on site on Tuesday 24 January and finish on Friday 27 January following the regular programme Participants need to bring their own laptops They will be requested to install software at a later stage Day 1 Tuesday 24 January 2023 Time Europe Berlin SpeakerLocation08 40Shuttle bus from ISG Hotel to EMBLISG Hotel entrance09 00 09 30Arrival welcome course overview and safety briefingCourtyard room A B09 30 10 30Flash talks and setup checkLisanna Paladin EMBL Heidelberg GermanyCourtyard room A B10 30 11 00Coffee BreakCourtyard foyer11 00 12 30Data Organization in SpreadsheetsLisanna Paladin EMBL Heidelberg GermanyCourtyard room A B12 30 13 30Lunch breakEMBL Canteen13 30 15 00OpenRefine for Data Cleaning Social NetworkingLisanna Paladin EMBL Heidelberg GermanyCourtyard room A B15 00 15 30 Coffee Break Courtyard foyer 15 30 17 30OpenRefine for Data Cleaning Social Networking Lisanna Paladin EMBL Heidelberg GermanyCourtyard room A B 17 30 18 30DinnerEMBL Canteen18 45Shuttle bus to ISG HotelATC entrance Day 2 Wednesday 25 January 2023 Time Europe Berlin SpeakerLocation08 40Shuttle bus from ISG Hotel to EMBL ISG Hotel entrance 09 00 11 00Versioning with GitRenato Alves EMBL Heidelberg Germany Courtyard Room A B 11 00 11 30Coffee Break Courtyard foyer 11 30 12 30Versioning with GitRenato Alves EMBL Heidelberg GermanyCourtyard Room A B 12 30 13 30Lunch breakEMBL Canteen13 30 15 00Introduction to RGaurav Diwan University of Heidelberg Germany Courtyard Room A B 15 00 15 30Coffee Break Courtyard foyer 15 30 18 00Introduction to RGaurav Diwan University of Heidelberg GermanyCourtyard Room A B 18 00 19 00DinnerEMBL Canteen19 00 Shuttle bus to ISG Hotel ATC entrance Day 3 Thursday 26 January 2023 Time Europe Berlin SpeakerLocation08 40Shuttle bus from ISG Hotel to EMBL ISG Hotel entrance 09 00 10 30Data manipulation with dplyrSupriya Khedkar EMBL Heidelberg Germany Courtyard room A B 10 30 11 00Coffee Break Courtyard Foyer 11 00 12 30Data manipulation with dplyrSupriya Khedkar EMBL Heidelberg GermanyCourtyard room A B 12 30 13 30Group photo and lunch breakEMBL Canteen13 30 17 00Data visualisation with ggplot2Eleonora Mastrorilli EMBL Heidelberg GermanyCourtyard room A B 15 00 15 30Coffee Break Courtyard foyer 15 30 17 30Data visualisation with ggplot2Eleonora Mastrorilli EMBL Heidelberg Germany Courtyard room A B 17 45Shuttle bus to downtownATC entrance18 30Social Course Dinner Downtown Day 4 Friday 27 January 2023 Time Europe Berlin SpeakerLocation08 40 Shuttle bus from ISG Hotel to EMBL ISG Hotel entrance 09 00 10 30Data analysis with applications to genomicsFotis Psomopoulos Center for Research and Technology Hellas CERTH GreeceCourtyard room A B 10 30 11 00Coffee BreakCourtyard foyer 11 00 12 30Data analysis with applications to genomicsFotis Psomopoulos Center for Research and Technology Hellas CERTH GreeceCourtyard room A B 12 30 13 30Lunch breakEMBL Canteen13 30 15 00Data analysis with applications to genomicsFlorian Huber EMBL Heidelberg GermanyCourtyard room A B 15 00 15 30Coffee BreakCourtyard foyer 15 30 17 00Data analysis with applications to genomicsFlorian Huber EMBL Heidelberg GermanyCourtyard room A B 17 00 17 30Debrief and wrap upCourtyard room A B 17 45Shuttle bus to Heidelberg main train station ATC entrance Practical information Registration fees and motivation letter The course is limited to 28 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 320PhD Student 320Industry 530 NO visa support letters will be issued until payment of the registration fee is confirmed Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For detailed instructions please watch our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site EMBL Courses and virtual or on site EMBO Practical Courses in Heidelberg and will be indicated during the motivation letter submission process Your place in the course is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course within Europe up to 1000 for participants travelling to an EMBL Course from outside Europe up to 500 for any participant travelling to an EMBO Practical Course up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course up to 700 for any participant working in Croatia Czech Republic Estonia Greece Hungary Italy Lithuania Luxembourg Poland Slovenia and Turkey travelling to an EMBO Practical Course Registration fees are only covered for EMBO Practical Courses The organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO Practical Courses only For EMBO Practical Course participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course Eligible costs include fees for a babysitter or child care facility travel costs for a caregiver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 can be awarded per participant applying for an EMBO childcare grant Application You may apply for financial assistance when submitting your motivation letter for courses In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the course Selection is based on scientific merit your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and for further information about financial assistance please refer to the FAQ page Accommodation and shuttles HotelHotel rooms have been reserved for 4 nights 23 27 January 2023 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code DTC23 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings The bus schedule can be found here Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Technical requirements Below you will find the software and technical requirements for this course Please bring your own laptop You will be requested to install software at a later stage for which you will need admin rights on your laptop Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Request a sponsorship brochure Warning EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials One current scam campaign of which we are aware is conducted using the name Judy Eastman judy gopcontact a2hosted com and entails approaches to sponsors offering sponsorship opportunities on EMBL s behalf Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences symposia and courses is handled by EMBL directly and is sent from an official EMBL account EMBL does not work with any external providers on sponsorship acquisition Please also note that EMBL never provides attendee lists for purchase Any offers of such are fraudulent EMBL will never call or email you to ask for your credit card details or to request a payment All payments are on invoice Suspicious communications purportedly from for or on behalf of EMBL should be reported to EMBL at the following email address sponsorship embl de Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Renato Alves, Lisanna Paladin, Fotis Psomopoulos, Christian Schudoma

18 January 2023

Introduction to EMBL-EBI for teachers and trainers

Description EMBL EBI is the home of the world s most comprehensive range of freely available molecular databases and resources Our resources help researchers share and analyse data and perform complex queries in many different ways EMBL EBI also provides open access on demand training materials which are usable by teachers lecturers or trainers for teaching bioinformatics methods and tools During this webinar we will provide an overview of the range of EMBL EBI data resources and the role of EMBL EBI in making data open and accessible and an introduction to the training and materials EMBL EBI provides We will finish the webinar with a panel discussion to highlight the support for teachers that EMBL EBI Training provides which includes a large variety of free to access training material content This will help you identify specific topics in bioinformatics or EMBL EBI databases and tools the on demand training available and how you can access and adapt the training materials in your own teaching session Meet the panel Anna Swan Anna is a scientific training officer for e Learning at EMBL EBI She has a PhD in Bioinformatics from the University of Nottingham where she focused on the bioinformatic identification of biomarkers of osteoarthritis Following her PhD Anna worked as a medical writer spanning many therapeutic areas and working both on promotional and educational content for clinicians She has also worked as a data wrangler for the International Mouse Phenotyping Consortium at the project s data coordination centre based in the Medical Research Council s Harwell Institute Benjamin Moore Ben is Ensembl outreach manager and he organises workshops and other training events for Ensembl resources Ben has a PhD in Biological Sciences from the MRC Laboratory of Molecular Biology at the University of Cambridge Summer Rosonovski Summer is a Community Outreach Officer for Europe PMC an open literature database for life sciences developed by the European Bioinformatics Institute EMBL EBI Europe PMC indexes over 300 000 preprints abstracts and full text COVID 19 preprints from 20 life sciences preprint servers alongside published journal articles Before joining Europe PMC Summer obtained a PhD in Biophysics from The University of East Anglia investigating the alternative DNA structure the i motif Summer is passionate about accessibility in science believing that everyone should have access to research results and have the tools and training to understand scientific literature...

Anna Swan, Benjamin Moore, Summer Rosonovski

15 December 2022

Introducing PerMedCoE Building Blocks and Workflows to streamline biological analysis pipelines

Description Analysing biological datasets is nearly always a multi step process involving many interconnected stages Even so the lack of transparent approaches to managing complex data analysis pipelines remains a common challenge in the life sciences Another limiting factor is that completing such pipelines often requires in depth knowledge of many data analysis tools and programming languages There is therefore a continued need for methodologies that make complex biological data analysis pipelines easier to implement This webinar will present some of the main practical ways through which PerMedCoE seeks to make data analysis pipelines more manageable and accessible to researchers In particular the webinar will provide an overview of how the project addresses many biological use cases using a single shared approach in which semi automated workflows are constructed using purpose designed building blocks About the speaker Dr Jesse Harrison is a Senior Data Scientist and Project Manager at CSC IT Center for Science Ltd where he currently leads the Horizon EU BioDT project His other tasks have included R environment design maintenance and support on CSC computing platforms bioinformatics tool development and teaching Prior to joining CSC in 2019 Jesse held postdoctoral positions in microbial ecology astrobiology and environmental chemistry at the universities of Helsinki Turku Vienna and Edinburgh 2012 2019...

Jesse Harrison

14 December 2022

Exploring somatic mutations in cancer with the COSMIC database and analysis tools

Description COSMIC the Catalogue of Somatic Mutations in Cancer helps the global cancer research community conduct their science faster and better by presenting easy to understand streamlined and quality filtered data on cancer mutations We do this by providing high quality datasets curated by experts over the course of 18 years standardising our data into easily integrable formats and innovating with collaborators to provide analysis tools and actionable insights With 23 million genomic variants expertly curated from nearly 30 000 publications covering 6 800 precise forms of human cancer COSMIC is the world s largest manually curated database of somatic mutation information relating to human cancers This vast breadth and depth of high quality data is the gold standard relied upon by academic research and industry alike including pharmaceutical drug discovery and biotech companies This webinar will provide an introduction to COSMIC our process and demonstrate the vast range of data and analyses available via our multiple tools and projects We will focus particularly on two of our newer projects Cancer Mutation Census and Actionability which will be freely available for non commercial download as of 29 November 2022 We will also provide an opportunity for questions and hope that by the end of the webinar you will feel confident in exploring COSMIC s tools and understand how they can add value to your work...

Rebecca White, Steven Jupe, Jennifer Wilding, Michael Starkey, Helder Pedro

8 December 2022

Automated annotation in UniProt

Description UniProt is a high quality comprehensive protein resource in which the core activity is the expert review and annotation of proteins where the function has been experimentally investigated At the same time the UniProt database contains large numbers of proteins which are predicted to exist from gene models but which do not have associated experimental evidence indicating their function UniProt commits significant resources to developing computational methods for functional annotation of these predicted proteins based on the data in entries that have gone through the expert review process We will describe the two main automated annotation systems currently in use First UniRule which is an established UniProt system in which curators manually develop rules for annotation Second ARBA Association Rule Based Annotator which is a multi class learning system which uses rule mining techniques to generate concise annotation models ARBA employs a data exclusion algorithm that censors data not suitable for computational annotation and generates human readable rules for each UniProt release As part of our interest in engaging with the machine learning community we will also introduce the contribution of ProtNLM Protein Natural Language Model from Google Research which annotates proteins which have uncharacterised names We will also introduce UniFIRE an open source software that enables researchers to annotate their own protein dataset by using the above mentioned annotation systems In order to provide an easy and straightforward way to download and set up this tool we have containerised UniFIRE together with all its dependencies and the latest set of UniRule and ARBA rules In this webinar we will show how to create functional predictions for protein sequences by using this container image...

Pedro Raposo, Elena Speretta

7 December 2022

Chemical biology Q&A session

Description This Q A question and answer webinar will provide an opportunity for anyone who has completed Chemical biology A curated set of EMBL EBI online courses to join some of EMBL EBI s experts and ask their own questions This session will focus on exploring chemical compounds or drug molecules finding drug targets and target disease associations using resources such as ChEMBL and Open Targets The questions covered during the Q A webinar will depend on those asked by attendees however we will likely cover topics such as Curation and maintenance of chemical compounds database Chemogenomics Finding data about interactions between drugs or drug like molecules and their targets Drug discovery and target identification...

7 December - 9 December 2022

The spectra of life: dimensional breadth in biological research

Description...

2022 EMBL PhD Symposium Organising Committee

30 November 2022

Biocuration Q&A session

Description This Q A question and answer webinar will provide an opportunity for anyone who has completed Biocuration A curated set of EMBL EBI online courses to join some of EMBL EBI s experts and ask their own questions This session will focus on the role of biocuration in maintaining life science data and general data management It will also highlight the application of programming and text mining in biocuration The questions covered during the Q A webinar will depend on those asked by attendees however we will likely cover topics such as Biocuration principles Data management of biological data and open data Programming and text mining for biocurators Finding the right EMBL EBI resource for accessing or submitting data...

29 November - 2 December 2022

Protein quality control for downstream processes

Description OverviewSpeakers ProgrammePractical informationSponsorsMedia kit Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview Purified proteins are used in various types of scientific experiments and fields For example in structural biology insights into the functional mechanisms can be obtained by elucidating the 3D molecular structure of proteins and protein complexes using technologies such as X ray crystallography cryo EM and NMR In biochemistry and biophysics interactions with other proteins nucleic acids and small molecules can be studied by determining affinities and specificities Proteins can function as antigens to generate specific antibodies or as reagents in cell biology experiments Furthermore recombinant proteins can be used as tool molecules in genomics chemical biology and microscopy assays In order for these experiments to produce reliable and biologically relevant results they must be performed using high quality proteins that are active properly folded in the right oligomeric state and contain correctly inserted co factors Ensuring that these parameters are fulfilled requires quality control In this course we want to help the participants to become acquainted with the concept of protein quality control and provide them with an overview of the specific protein requirements for various downstream applications Different techniques that can be applied for this purpose will be introduced and participants will have the opportunity to get hands on experience with these technologies Audience This course is aimed at life science researchers of all levels who are using or plan to use purified proteins in their wet lab experiments but who do not necessarily have a strong background in protein production and characterisation methods We will focus on introducing protein quality control methodologies in order to improve the reliability and reproducibility of data obtained from experiments that make use of purified proteins After this course participants should be familiar with the biochemical and biophysical techniques that can be applied to ensure that they are working with high quality protein samples suitable for the planned downstream experiments Modules resources Isothermal Titration Calorimetry ITC and Dynamic Light Scattering DLS Nano Differential Scanning Fluorimetry nano DSF and MicroScale Thermophoresis MST Size Exclusion Chromatography coupled to Multi Angle Light Scattering and Dynamic Light Scattering SEC MALS DLS and Mass PhotometryCryo Electron Microscopy cryo EM Learning outcomes During the course specialists from both academia and industry will work closely together to introduce technologies frequently used in protein quality control Some of these methodologies can be utilised both to assess protein quality and as stand alone biophysical characterisation techniques One of the highlights of the course that we are very excited about is the cryo electron microscopy cryo EM practical Cryo EM has undergone a revolution in recent years and is becoming increasingly popular in many interdisciplinary projects However in order to attain high resolution data the protein samples need to fulfil quite stringent conditions Our main goals are Teach the participants how to perform proper protein quality control checksIntroduce the participants to various biophysical techniques used for protein characterisation such as SEC MALS DLS mass photometry nano DSF spectroscopy and mass spectrometryShow participants how to characterise protein interactions using ITC and MSTProvide participants with a basic background on cryo EM and show the effects sample quality has on the acquired dataWhere possible allow participants to apply these technologies onto their own protein samples in the practicalsOverall increase the success rate reliability and reproducibility of downstream experiments in which purified proteins are used Speakers Speakers trainers and staff Inessa De BASF Germany Melisse Erasmus Refeyn UK Sebastian Eustermann EMBL Heidelberg Germany Simon Fromm EMBL Heidelberg Germany Maria Garcia Alai EMBL Hamburg Germany Pravin Kumar Ankush Jagtap EMBL Heidelberg Germany Sebastian Joecks Refeyn UK Arpita Kundu NanoTemper Germany Karine Valerie Lapouge EMBL Heidelberg Germany Andr Matagne Universit de Li ge Belgium Melanie McDowell Max Planck Institute of Biophysics Germany Bertrand Raynal Institut Pasteur France Kim Remans EMBL Heidelberg Germany Mandy Rettel EMBL Heidelberg Germany Agatha Rosenthal Malvern Panalytical Germany Jan Schnatwinkel NanoTemper Germany Christian Sieg Wyatt Germany Bernd Tartsch Malvern Panalytical Germany Scientific organisers Karine Valerie Lapouge EMBL Heidelberg Germany Kim Remans EMBL Heidelberg Germany Course organisers Lea Hohmann Course and Conference Manager EMBL Heidelberg Germany Swetlana Krez Training Lab Technician EMBL Heidelberg Germany Programme Got something to say Tweet it with EMBLProteinQC Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 1 Tuesday 29 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus from hotel to EMBL ATC EntranceISG Hotel09 00 09 45Welcome and house notes and course overviewFlex Lab A B09 45 10 45Flash talks 5min Introduction round and Challenges and Expectations Flex Lab A B10 45 11 15Coffee BreakFlex Lab A B11 15 12 15Flash talks 5min Introduction round and Challenges and Expectations cont Flex Lab A B12 15 13 30LunchCanteen13 30 14 15Lecture An overview of protein expression and purification methods for obtaining high quality protein samplesKim Remans EMBL Heidelberg GermanyFlex Lab A B14 15 15 00Lecture An overview of Protein quality control The example of Institut PasteurBertrand Raynal Institut Pasteur FranceFlex Lab A B15 00 15 30Coffee BreakFlex Lab A B15 30 18 304 practicals in parallelPractical 1 Isothermal Titration Calorimetry ITC and Dynamic Light Scattering DLS Agatha Rosenthal Malvern Panalytical GermanyBernd Tartsch Malvern Panalytical GermanyPractical 2 Nano Differential Scanning Fluorimetry nano DSF and MicroScale Thermophoresis MST Arpita Kundu NanoTemper Germany Jan Schnatwinkel NanoTemper Germany Practical 3 Size Exclusion Chromatography coupled to Multi Angle Light Scattering and Dynamic Light Scattering SEC MALS DLS and Mass PhotometryMelisse Erasmus Refeyn UKSebastian Joecks Refeyn UKChristian Sieg Wyatt GermanyPractical 4 Cryo Electron Microscopy cryo EM Simon Fromm EMBL Heidelberg Germany Training Lab BIC building room 12518 30 20 00DinnerRoof top lounge 20 00Departure to HotelATC Entrance Day 2 Wednesday 30 November 2022 Time Europe Berlin SessionLocation09 00 09 10Overview of the dayFlex Lab A B 09 10 12 104 practicals in parallelPractical 1 Isothermal Titration Calorimetry ITC and Dynamic Light Scattering DLS Agatha Rosenthal Malvern Panalytical GermanyBernd Tartsch Malvern Panalytical GermanyPractical 2 Nano Differential Scanning Fluorimetry nano DSF and MicroScale Thermophoresis MST Arpita Kundu NanoTemper GermanyJan Schnatwinkel NanoTemper Germany Practical 3 Size Exclusion Chromatography coupled to Multi Angle Light Scattering and Dynamic Light Scattering SEC MALS DLS and Mass PhotometryMelisse Erasmus Refeyn UKSebastian Joecks Refeyn UKChristian Sieg Wyatt GermanyPractical 4 Cryo Electron Microscopy cryo EM Simon Fromm EMBL Heidelberg Germany Training Lab BIC building room 12512 10 13 15LunchCanteen13 15 14 00Lecture Quality control of protein RNA complexes for structural studiesPravin Kumar Ankush Jagtap EMBL Heidelberg GermanyFlex Lab A B14 00 14 45Lecture Quality control for membrane proteinsMelanie McDowell Max Planck Institute of Biophysics GermanyFlex Lab A B14 45 15 15Coffee breakFlex Lab A B15 15 18 154 practicals in parallelPractical 1 Isothermal Titration Calorimetry ITC and Dynamic Light Scattering DLS Agatha Rosenthal Malvern Panalytical GermanyBernd Tartsch Malvern Panalytical GermanyPractical 2 Nano Differential Scanning Fluorimetry nano DSF and MicroScale Thermophoresis MST Arpita Kundu NanoTemper GermanyJan Schnatwinkel NanoTemper Germany Practical 3 Size Exclusion Chromatography coupled to Multi Angle Light Scattering and Dynamic Light Scattering SEC MALS DLS and Mass PhotometryMelisse Erasmus Refeyn UKSebastian Joecks Refeyn UKChristian Sieg Wyatt GermanyPractical 4 Cryo Electron Microscopy cryo EM Simon Fromm EMBL Heidelberg Germany Training Lab B18 15Dinner downtown Day 3 Thursday 1 December 2022 Time Europe Berlin SessionLocation09 00 09 10Overview of the dayFlex Lab A B09 10 10 40Lecture CD and Optical Spectroscopy for Protein Quality ControlAndr Matagne Universit de Li ge BelgiumFlex Lab A B10 40 11 00Coffee breakFlex Lab A B11 00 11 45Lecture Protein production characterisation and quality control processes in industryInessa De BASF GermanyFlex Lab A B11 45 12 30Lecture Why should we use Proteomics for protein quality controlling Mandy Rettel EMBL Heidelberg GermanyFlex Lab A B12 30 13 30LunchCanteen13 30 14 15Lecture Production of protein complexes for cryo EMSebastian Eustermann EMBL Heidelberg GermanyFlex Lab A B14 15 14 45Lecture Advanced characterisation of membrane proteinBertrand Raynal Institut Pasteur FranceFlex Lab A B14 45 15 15optional Core Facility TourCore Facility15 00 15 30Coffee breakFlex Lab A B15 30 18 304 practicals in parallelPractical 1 Isothermal Titration Calorimetry ITC and Dynamic Light Scattering DLS Agatha Rosenthal Malvern Panalytical GermanyBernd Tartsch Malvern Panalytical GermanyPractical 2 Nano Differential Scanning Fluorimetry nano DSF and MicroScale Thermophoresis MST Arpita Kundu NanoTemper GermanyJan Schnatwinkel NanoTemper Germany Practical 3 Size Exclusion Chromatography coupled to Multi Angle Light Scattering and Dynamic Light Scattering SEC MALS DLS and Mass PhotometryMelisse Erasmus Refeyn UKSebastian Joecks Refeyn UKChristian Sieg Wyatt GermanyPractical 4 Cryo Electron Microscopy cryo EM Simon Fromm EMBL Heidelberg GermanyTraining Lab BIC building room 11418 30 20 00DinnerEMBL Canteen20 00Departure to Hotel Day 4 Friday 2 December 2022 Time Europe Berlin SessionLocation09 30 11 00Round table with speakers instructors and all participantsRooftop lounge11 00 11 30Coffee breakFlex Lab A B 11 30 12 00Feedback and closing remarksFlex Lab A B 12 00 12 15Departure and packed lunch Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Academia 600PhD Student 600Industry 1100 Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For more detailed information follow the instructions provided in our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events in Heidelberg and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Boehringer Ingelheim Fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance at the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details See our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Hotel Single rooms have been reserved for 4 nights 28 November 02 December 2022 at the ISG Hotel After the selection process selected participants should contact the hotel directly to make a booking booking code PQC22 01 We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings The bus schedule can be found here Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other events or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Karine Lapouge, Kim Remans

23 November 2022

The environmental impact of computational biology

Description The environmental impact of scientific computing computational biology in particular is a growing concern in light of the urgency of the climate crisis and there is widespread interest in the research community so what can we all do about it Tackling this issue and making it easier for scientists to engage with sustainable computing is what motivated the Green Algorithms project During this webinar we will discuss what we learned along the way how to estimate the impact of our work and dive into the carbon footprint of common bioinformatic analyses We will also highlight the levers scientists and institutions have to make their research more sustainable debate the ethical implications of these environmental costs and examine what is still needed moving forward About the speaker Dr Lo c Lannelongue is a Research Associate in Biomedical Data Science in the Cardiovascular Epidemiology Unit and the Inouye lab at the University of Cambridge He is also a College Post Doctoral Associate at Jesus College Cambridge and an Associate Fellow of Advance HE Lo c developed the Greener Algorithms project in collaboration with Jason Grealey and Michael Inouye to understand the carbon footprint of analyses and promote best practices in green computing...

Loïc Lannelongue

23 November - 25 November 2022

Managing a bioinformatics core facility

Description This knowledge exchange workshop is an opportunity for managers of bioinformatics core facilities to learn from EMBL EBI s service teams and from each other These facilities play an essential role in enabling research in the molecular life sciences The landscape is constantly evolving as new research tools emerge as experiments become increasingly data intensive and as their clients experimental researchers become more exposed to the power of data driven biology This course will allow participants to share experiences discuss challenges and solutions that they face and plan ways to cope with the ever changing demands raised by the molecular life science field It will include sessions to learn from data providers at EMBL EBI hear how others have tackled common problems and work together to design core services...

Sophie Spencer

22 November - 24 November 2022

Open Virtual Ensembl API Workshop

Description Work with Ensembl to master the Ensembl REST API and flexibly access genome wide data such as genes variants regulatory features homologues and alignments...

Aleena Mushtaq

17 November 2022

Uncovering protein function with UniProt

Description The webinar will cover what functional information is available in UniProt and where that information comes from It will also describe how the information is added to the resource and how to find it on the UniProt website...

Michele Magrane

15 November 2022

Croupier, an user-centric meta-orchestrator for cross-platform workflow delivery and execution

Description The orchestration of complex application workflows executed in the context of High Performance Computing HPC infrastructures requires the joint collaboration of application designers developers HPC engineers and application consumers i e end users In the context of HPC complex workflows can be executed with either HPC schedulers e g Slurm workflow managers e g PyCOMPSs NextFlow with meta orchestrators e g Croupier or with a combination of them While schedulers and workflow managers are restricted to execute applications within a single HPC cluster Croupier supports cross platform application delivery execution monitoring and data management In this webinar we will introduce Croupier from the application designers and consumers perspective and the use of Croupier with a demo on how to deploy execute and monitor one of the PerMedCoE use case applications About the speaker Jes s has been working in diverse ICT companies as Software Analyst and Architect for 20 years In Atos Research Innovation ARI he is Chief Architect and Senior Researcher on the AI Data HLS Unit member of the Advanced Parallel Computing Group where he designs and develops cross platform meta orchestrators for HPC infrastructures in EC R D i projects such as EUXDAT Hidalgo Grapevine or PerMedCoE He is also Atos Technical Team Leader of AI centric project IoT NGIN...

15 November 2022

Systematising complex and combined metabolic analyses with COBREXA.jl

Description Constraint based reconstruction and analysis COBRA refers to a vast collection of methods that build and scrutinise large metabolic networks traditionally using the methodology of linear optimization Many current analysis methods work with models that are personalised or customised to reflect genomic proteomic and other measurements At the same time there is a natural need to simulate more complex phenomena that emerge from combinations of many individual models such as multi organ and multi organism networks The complexity of the computations that need to be organised to run such simulations naturally grows up to a point where the analysis may become infeasible In this course we will introduce COBREXA jl a toolkit for working with large constraint based metabolic models and running very large parallel analysis tasks on these models Its main purpose is to make the COBRA methods scale to problem sizes that require the use of large computer clusters and high performance computing HPC Visit COBREXA jl website to find more information and guides The course will combine lectures and hands on exercises using several new design patterns implemented in COBREXA jl to organise many different model combinations constraints modifications and personalizations in a systematic way allowing short and concise implementations of extremely complex huge scale analyses...

Daniel Thomas López

15 November - 17 November 2022

Open Virtual Ensembl Browser Workshop

Description Work with the Ensembl Outreach team to get to grips with the Ensembl browser accessing gene variation comparative genomics and regulation data and mine these data with BioMart...

Aleena Mushtaq

15 November - 18 November 2022

From functional genomics to systems biology

Description OverviewSpeakersProgrammePractical informationSponsorsMedia kit Overview This conference will take place at EMBL Heidelberg with the option to attend virtually Please see EMBL s COVID 19 safety policy for testing and other requirements if attending the on site event Conference overview Genomics proteomics and quantitative imaging are rapidly moving fields with technological innovations and new biological insights occurring on an almost monthly basis For example mass spectrometry based proteomics is now able to quantitatively assess close to 80 of the proteome which can nowadays be obtained from very low cell numbers An even greater jump in sensitivity has recently revolutionized genomics with the rapid spread of measurements at the resolution of single molecule and single cells Development of new methods and instruments has led to the emergence of high content quantitative microscopy that enables quantification of dozens of phenotypic readouts in single cells A common feature of all these techniques is their ability to generate large amounts of high resolution quantitative data characterizing biological systems at scales ranging from molecular to organismal level A topical challenge is to convert this data into predictive quantitative models of biological systems From functional genomics to systems biology is a venue for scientific leaders to discuss their data beyond their field and promote the emergence of ideas and concepts to bridge the gap between technologies and scales to model complex biological systems Session topics From molecules to cells From cells to organsFrom biological systems to disease What past participants say about the conference Attending this conference revealed ideas of methods and tools that can be applied by my team in some aspects of our planned future research The conference organization and execution skills surpassed the expectation I had of an EMBL event Thank you for this great experience Joy Ehiwuogu Onyibe Federal Institute of Industrial Research Oshodi FIIRO Nigeria A very beautifully organized virtual conference with excellent presentations in a professional environment that encourages young researchers Muhammad Nisar Ali Nigde Omer Halisdemir University Turkey Speakers Speakers Stein Aerts KU Leuven Belgium Pedro Beltrao EMBL EBI Hinxton UK and ETH Zurich Switzerland Lacra Bintu Stanford University USA Bernd Bodenmiller University of Zurich ETH Zurich Switzerland Giovanni D Angelo Swiss Federal Institute of Technology Lausanne Switzerland Carl de Boer University of British Columbia Canada Leeat Keren Weizmann Institute of Science Israel Arnaud Krebs EMBL Heidelberg Germany Anna Kreshuk EMBL Heidelberg Germany Mounia Lagha The Institute of Molecular Genetics of Montpellier France Prisca Liberali Friedrich Miescher Institute for Biomedical Research Switzerland Julia Mahamid EMBL Heidelberg Germany Christine Mayr Memorial Sloan Kettering Cancer Center USA Marcelo Nollmann CNRS INSERM France Athma Pai University of Massachusetts Chan Medical School USA Lucas Pelkmans University of Zurich Switzerland Alexandros Pertsinidis The Sloan Kettering Institute USA Markus Ralser Charit Universit tsmedizin Berlin Germany Juri Rappsilber Technische Universit t Berlin Germany Mikhail Savitski EMBL Heidelberg Germany Georg Seelig University of Washington USA Virtual speaker Hugo Snippert University Medical Center Utrecht The Netherlands Winston Timp John Hopkins University USA Judit Villen University of Washington USA Virtual speaker Scientific organisers Arnaud Krebs EMBL Heidelberg Germany Prisca Liberali Friedrich Miescher Institute for Biomedical Research Switzerland Mikhail Savitski EMBL Heidelberg Germany Georg Seelig University of Washington USA Conference organiser Raili Pall EMBL Heidelberg Germany Programme Got something to say Tweet it EMBOOmics For registered participants recorded talks will be accessible on demand for 2 weeks after the end of the event unless indicated otherwise Please find the poster listing here Day 1 Tuesday 15 November 2022 Time Europe Berlin Speaker12 15 13 30Registration and light refreshments13 30 13 45Opening remarks by Prisca Liberali and Arnaud Krebs13 45 18 00Session 1 From molecules to cellsChairs Mounia Lagha The Institute of Molecular Genetics of Montpellier France and Dan Lu Harvard Medical School USA13 45 14 10High throughput discovery and systematic sequence characterization of human transcriptional regulatorsLacra Bintu Stanford University USA14 10 14 30Deep mutational scanning of entire human protein interaction domain families Guillaume Diss Friedrich Miescher Institute for Biomedical Research Switzerland14 30 14 55Self organization in intestinal organoidsPrisca Liberali Friedrich Miescher Institute for Biomedical Research Switzerland14 55 15 15SPIDR a novel and highly multiplexed method for mapping RNA protein interactions to comprehensively study post transcriptional gene expression regulation Marko Jovanovic Columbia University USA15 15 15 40In cell interaction networks to understand integrated processesJuri Rappsilber Technische Universit t Berlin Germany 15 40 16 10Coffee break16 10 16 35Inspecting roles of 3D chromatin organization in transcription by multiplexed chromatin imagingMarcelo Nollmann CNRS INSERM France16 35 16 55Uncovering the molecular rules of chromatin module formationJudith Kribelbauer Swiss Federal Institute of Technology Lausanne Switzerland16 55 17 15Genomic context and histone marks define pioneer binding to nucleosomes Luca Mariani Brigham and Women s Hospital Harvard Medical School USA17 15 17 35Single molecule live cell imaging shows that DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genesTineke Lenstra Netherlands Cancer Institute Oncode Institute The Netherlands17 35 18 00Analysis of tumor ecosystems by spatial proteomics for precision medicineBernd Bodenmiller University of Zurich ETH Zurich SwitzerlandRecording not available 18 00 18 30Available for onsite participants onlyPanel discussion 1 Understanding genomes current breakthrough in the field with pre dinner drinks at ATC Foyer Panellists Lacra Bintu Stanford University USAJustin Crocker EMBL Heidelberg GermanyMounia Lagha The Institute of Molecular Genetics of Montpellier FranceZohar Shipony Ultima Genomics IsraelModerated by Arnaud Krebs EMBL Heidelberg Germany18 30 20 00Dinner EMBL canteen 20 00 21 30Social event pub quiz EMBL canteen 21 30 22 30Social event networking drinks ATC Rooftop Lounge Day 2 Wednesday 16 November 2022 Time Europe Berlin Speaker09 00 12 10Session 2 From molecules to cells continued Chairs Judith Kribelbauer Swiss Federal Institute of Technology Lausanne Switzerland and Guillaume Diss Friedrich Miescher Institute for Biomedical Research Switzerland09 00 09 25Biochemical activity is the default DNA state in eukaryotesCarl de Boer University of British Columbia Canada09 25 09 45Dynamic p53 post translational modifications regulate cellular fatesDan Lu Harvard Medical School USA09 45 10 05Chromatin accessibility is a two tier process regulated by transcription factor pioneering and enhancer activation Kaelan Brennan Stowers Institute for Medical Research USA10 05 10 30Elucidating mechanisms underlying coupled transcription initiation and 3 end cleavagAthma Pai University of Massachusetts Chan Medical School USA10 30 11 00Coffee break 11 00 11 25Understanding gene regulation using single molecule genomicsArnaud Krebs EMBL Heidelberg Germany11 25 11 45A race to identify the genes that support neutrophil cell migrationNathan Belliveau University of Washington HHMI USA11 45 12 10Revealing promoter enhancer communication mechanisms by high resolution single gene imagingAlexandros Pertsinidis The Sloan Kettering Institute USARecording not available12 10 13 45Lunch13 45 15 45Poster session 1 odd numbers ATC Helix APoster listing15 45 18 55Session 3 From cells to organsChairs Nathan Belliveau University of Washington HHMI USA and Lacra Bintu Stanford University USA15 45 16 10Multimodal perception links cellular state to decision making in single cellsLucas Pelkmans University of Zurich Switzerland16 10 16 30Clonally resolved single cell multi omics identifies routes of cellular differentiation in acute myeloid leukemiaLars Velten Center for Genomic Regulation CRG Spain16 30 16 50CRISPRi screen of schizophrenia risk genes elucidates the role of epigenetic regulators in neurons and progenitorsAnnique Claringbould EMBL Heidelberg Germany16 50 17 15Gene expression dynamics during the awakening of the zygotic genomeMounia Lagha The Institute of Molecular Genetics of Montpellier FranceRecording not available17 15 17 45Coffee break 17 45 18 10Finding biology in microscopy images with machine learningAnna Kreshuk EMBL Heidelberg Germany18 10 18 30Barcode free predictions of cell lineages from single cell transcriptome dataAlmut Eisele EPFL SwitzerlandRecording not available18 30 18 55Learning the rules of mRNA processing from massivelyparallel experiments and machine learningGeorg Seelig University of Washington USA Virtual speaker 18 55 20 30Dinner EMBL canteen Day 3 Thursday 17 November 2022 Time Europe Berlin Speaker09 00 12 05Session 4 From cells to organs continued Chairs Lars Velten Center for Genomic Regulation CRG Spain and Christine Mayr Memorial Sloan Kettering Cancer Center USA09 00 09 25Sphingolipids control dermal fibroblast heterogeneityGiovanni D Angelo Swiss Federal Institute of Technology Lausanne Switzerland09 25 09 45Applications of optimal transport theory to single cell analysesAngela Goncalves German Cancer Research Center DKFZ Germany09 45 10 05Can we accurately estimate gene regulatory networks from single cell data Julio Saez Rodriguez University of Heidelberg Germany10 05 10 35Coffee break 10 35 11 00Unraveling the tumor microenvironment using multiplexed imagingLeeat Keren Weizmann Institute of Science IsraelRecording not available11 00 11 20RANKL dependent ONECUT2 regulation of Enterocyte and Microfold cell differentiation in the small intestine a multi omics studyMaria Victoria Luna Velez Radboud University Nijmegen The Netherlands11 20 11 40Laboratory evolution of flies to morphogen dosage via rapid maternal changes reveals predictable outcomesJustin Crocker EMBL Heidelberg Germany11 40 12 05Heterogeneity in tumors evolving genomes at single cell resolutionHugo Snippert University Medical Center Utrecht The Netherlands12 05 13 30Lunch Optional walk run together registered participants only 13 30 15 30Poster session 2 even numbers ATC Helix APoster listing15 30 18 40Session 5 From biological systems to diseaseChairs Frank Albert University of Minnesota USA and Athma Pai University of Massachusetts Chan Medical School USA15 30 15 55A high dimensional atlas of phosphorylation dependent signalingJudit Villen University of Washington USA Virtual speaker 15 55 16 20Functional proteomics to assess the system scale nature of metabolismMarkus Ralser Charit Universit tsmedizin Berlin Germany16 20 16 40ProteasomeID quantitative mapping of proteasome interactomes and substrates for in vitro and in vivo studiesAlessandro Ori Leibniz Institute on Aging Fritz Lipmann Institute Germany16 40 17 05Towards a tissue specific and structurally resolved human interactomePedro Beltrao EMBL EBI Hinxton UK and ETH Zurich Switzerland17 05 17 35Coffee break 17 35 17 55Correlated light and electron microscopy volume imaging of organoid cell culturesEdoardo D Imprima EMBL Heidelberg GermanyRecording not available17 55 18 15From regulatory landscapes to complex intercellular dependencies using the gastruloid model systemLuca Braccioli The Netherlands Cancer Institute The Netherlands18 15 18 40Enabling discovery by in cell structural biologyJulia Mahamid EMBL Heidelberg Germany18 40 19 10Available for onsite participants onlyPanel discussion 2 From protein identification to function with pre dinner drinks at ATC Foyer Panellists Pedro Beltrao EMBL EBI Hinxton UK and ETH Zurich SwitzerlandGuillaume Diss Friedrich Miescher Institute for Biomedical Research SwitzerlandMarko Jovanovic Columbia University USARodrigo Villase or Biomedical Center Munich GermanyModerated by Mikhail Savitski EMBL Heidelberg Germany19 10 21 00Conference dinner EMBL canteen 21 00 23 00Social evening with live DJ ATC Rooftop Lounge Day 4 Friday 18 November 2022 Time Europe Berlin Speaker09 00 12 30Session 6 From biological systems to disease continued Chairs Pedro Beltrao EMBL EBI Hinxton UK and ETH Zurich Switzerland and Alessandro Ori Leibniz Institute on Aging Fritz Lipmann Institute Germany 09 00 09 25Deciphering gene regulatory networks and enhancer logic from single cell multi omics dataStein Aerts KU Leuven Belgium09 25 09 45Exon resolution functional genomics uncovers critical protein regions for cellular functionThomas Gonatopoulos Pournatzis National Cancer Institute National Institutes of Health USARecording not available09 45 10 05Targeted transcription factor degradation and nascent transcriptomics reveal a new model of core transcriptional regulatory circuitryMaxim Pimkin Dana Farber Cancer Institute and Boston Children s Hospital and Harvard Medical School10 05 10 30Biophysical proteomicsMikhail Savitski EMBL Heidelberg Germany10 30 11 00Coffee break 11 00 11 25Identification of global and gene specific regulators of alternative polyadenylation using Perturb seqChristine Mayr Memorial Sloan Kettering Cancer Center USA 11 25 11 45Exploring the vulnerabilities of EGFR dependent breast cancer cells with single cell lineage tracingMelania Franchini University of Naples Federico II Italy11 45 12 05Genetic variation in ubiquitin system genes creates complex pathway specific effects on proteasomal protein degradation Frank Albert University of Minnesota USA12 05 12 30Decoding the central dogma with single moleculesWinston Timp John Hopkins University USA12 30 12 45Closing remarks and poster prize announcement12 45Packed lunch and departure13 15Optional Shuttle bus to Frankfurt Airport Terminal 1 Tickets can be purchased on site during the conference for 25 EUR Practical information Registration fees and abstract submission On site registration fees include admission conference materials COVID 19 safety measures meals and coffee breaks Participants are expected to book and pay their own accommodation and travel expenses Virtual registration fees include access to all of the talks live streamed and on demand and facility to submit questions On site Academia 450On site PhD Student 350On site Industry 750Virtual Academia 175Virtual PhD Student 125Virtual Industry 225 NO visa support letters will be issued until payment of the registration fee is confirmed Accredited journalists may be eligible to register for complimentary press registration Registrants may be required to provide accreditation or equivalent proof of press membership after registration Please contact Raili Pall for more information Please note that we do not offer complimentary registrations for editors of scientific journals Confirmation and payment Registration will be on a first come first served basis Your place can only be confirmed after payment of the registration fee If you are added to our waiting list please consider taking advantage of our offerings to participate virtually On site participants Types of payments accepted are international bank transfers and credit card payments Virtual participants We are only able to accept card payments In exceptional cases we can accept bank transfers Please contact events embl de for details Abstract submission Only registered participants attending the on site event are eligible to submit an abstract Abstracts will not be accepted from virtual participants After you have logged in and successfully registered you will receive an email asking you to submit your abstract Click on the link provided and enter your abstract in the text box provided Alternatively you can submit your abstract by clicking on the link on the confirmation page directly after registering The same login credentials are used for both processes Please note Title The title should not exceed 20 words Only the first word of the title should start with a capital letter and the rest of the title should be in lowercase Authors and affiliations Please fill in the author s details as requested in the online form The compulsory details are First Name Last Name Organisation Name Affiliation or Company Country and Email Mark only one author as the role of First author and please don t forget to indicate who will be presenting The order of the authors will be listed as follows First Author Co First Author alphabetically if multiple co author s in the order added by the submitter Presentation types When submitting your abstract you can apply for an oral or poster presentation A selection process will take place with the results announced 2 3 weeks after the abstract submission deadline Please check our FAQs pages for further information on how to submit an abstract Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events in Heidelberg and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO practical courses and workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a baby sitter or child care facility travel costs for a care giver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation is not included in the conference registration fee As further changes in our events are possible due to COVID 19 you should book flights trains and hotels with flexible options and favourable cancellation conditions The hotels below have rooms on hold for participants until 14 October 2022 in some cases at special rates Please quote the booking code OMX22 01 and confirm the exact price of the room with the hotel directly Hotel AnlageHotel ibis HeidelbergPremier Inn Heidelberg CityHotel Bayrischer Hof ISG Hotel Staycity Aparthotel HeidelbergB B HotelLeonardo Hotel Heidelberg City CentreHotel Vier Jahreszeiten HeidelbergExzellenz Hotel Meininger HeidelbergHotel Holl nder Hof Hotel Monpti Conference shuttle buses Conference shuttle buses are free of charge for participants and depart from designated bus stops near the hotels to EMBL and back mornings and evenings Download the conference bus schedule here The bus stops for this conference are Staycity Aparthotel Speyerer Str 7 Kurf rsten Anlage opposite Main Train Station Premier Inn Hotel Kurf rsten Anlage 23 Leonardo Hotel City Centre Bergheimer Str 63 Neckarm nzplatz Heidelberg Tourist Information Peterskirche Bus stop ISG Hotel View Conference shuttle bus stops and hotels in a larger map Please note that not every bus stop will be used for every event Further details Address EMBL Meyerhofstra e 1 69117 Heidelberg Germany For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue For information about accommodation and local transportation please refer to the FAQ page On site information Catering All meals and coffee breaks are included in the registration fee Our catering staff will prepare a wide variety of vegetarian meals meat and fish dishes soups pasta fresh fruit and vegetables as well as a variety of desserts Please wear your badge at all times when serving yourself No food or drinks are allowed in the auditorium Charging lockers There are lockers available next to the stairs leading down into the Auditorium You will find some of those equipped with sockets to charge your smartphone tablet etc Electricity and charging station In most places the electricity is 220 volts AC 50 cycles An adaptor and a plug that fits the German socket may be needed for your appliances laptop i e American Japanese etc A USB charging station for electronic devices is available at the registration desk EMBL merchandise EMBL Merchandise is available on Mon Thu 9 am 12 pm If you are interested in purchasing an EMBL souvenir products presented in the glass display in the registration area please ask at the registration desk for more information Health and safety notes Please read EMBL s COVID 19 safety policy for on site events Do not smoke in any EMBL building Eating and drinking is prohibited in the Auditorium and all laboratories Do not enter any restricted areas or the laboratories unless instructed to do so If first aid is required The first aid room is located next to the ATC Registration Desk room 10 205 Dial the Emergency number 222 from any EMBL internal phone only Where is the accident What happened How many injured Emergency number 06221 387 7821 from mobile phones Please report all accidents to the conference officer at the registration desk In case of fire Press the nearest fire alarm button or the Emergency number 222 from any internal phone A loud fire alarm will go off if an evacuation is required On hearing the alarm leave the building immediately following the escape route and fire wardens and head to one of the meeting pointsDo not use the lifts Beyond first aid Please remember to bring your own medication if needed to the conference Note that the next pharmacy is a 4 minute drive from the EMBL but for many medications you will be required to see a doctor to get a prescription Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg In any case the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary Internet Wi Fi is available everywhere on the premises no password required just log on to ATC Guest The eduroam network secure world wide roaming access service developed for the international research and education community is also available Lost and found Lost and Found are kept at the registration desk until the end of the conference Luggage There are lockers available on site to store your luggage which require a 2 EURO coin to operate There is another luggage room on level E0 which is free to use but remains unlocked during the conference Nursing room There is a nursing room available in the ATC Rooftop Lounge on level A29 Photography During the conference an EMBL Photographer may be taking photographs If you would not like to appear in these please inform the photographer or a member of the Course and Conference Office Printing We can help printing your boarding passes train ticket Please send it to events embl de and collect your print outs at the registration desk Room for prayer yoga and meditation There is a room for prayer mediation and yoga located on level E0 behind the Auditorium Please be respectful of other participants using the room Sightseeing A variety of activities in Heidelberg can be found on the website of Heidelberg Marketing Travel to and from the venue During the event we provide conference shuttle buses to and from EMBL In addition there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page Useful German expressions EnglishGermanHelloHalloGoodbyeAuf WiedersehenGood morningGuten MorgenGood afternoonGuten TagGood eveningGuten AbendGood nightGute NachtI m sorryTut mir leidExcuse me Entschuldigen SieHow are you Wie geht s I m fine thanks And you Mir geht es gut danke und dir Ihnen What is your nameWie heisst du Wie heissen Sie My name isIch heisseDo you speak EnglishSprechen Sie Englisch I don t understandIch verstehe nichtPlease speak more slowlyK nnen Sie bitte langsamer sprechenThank youDanke sch nWhere is the toilet Wo ist die Toilette Please call me a taxiBitte rufen Sie mir ein TaxiHow do I get to Wie komme ich zum zur A beer two beers pleaseEin Bier zwei Bier bitteA glass of red white wine pleaseEin Glas Rot Weisswein bitteThe menu pleaseDie Speisekarte bitteIs there a local speciality Gibt es eine Spezialit t aus dieser Gegend I m VegetarianIch bin VegetarierIt was deliciousEs war hervorragendThe bill pleaseDie Rechnung bitteI have a headacheIch habe KopfschmerzenI have a sore throatIch habe HalsschmerzenMy stomach hurtsIch habe MagenschmerzenI m allergic toIch bin allergisch gegenI need a doctor who speaks EnglishGibt es einen Arzt der Englisch spricht Virtual participation What s included Access to all the livestreamed talksVideo library of the recorded talks during and after the eventFacility to submit questions Please note that only on site participants are able to submit abstracts and participate in the poster sessions Event platform We are using an event platform for this conference More information about the platform will be shared ahead of the conference Guidelines Do not broadcast the conference to unregistered participants You are encouraged to tweet and post about the event Tweet unless the speaker specifically says otherwise but be mindful of unpublished data Please do not capture transmit or redistribute data presented at the meeting Additional information can be found in our Code of Conduct Health and well being It is important to stay healthy and move around especially when you are attending an event virtually We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event How to ask questions Please use the Q A function in the event platform If you have any other questions you can go to the Help Desk in the event platform Click on more on the top menu and click Help Desk Time zone The programme is planned based on the Europe Berlin time zone unless otherwise stated Please take your time zone into consideration when planning your attendance Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Bronze sponsor Media partner International Union of Biochemistry and Molecular Biology Molecular Systems Biology an EMBO Press journal Open Biology a Royal Society journal Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information on sponsoring possibilities If you are interested in becoming a media partner of this event please visit our media partnerships webpage Media kit Want to let others know you re attending this event Take a look at our shareable media and feel free to use them in your social media channels or presentations Social 1080 1920 Social 1080 1080 Social 1600 900 PPT Slide 16 9...

Arnaud Krebs, Prisca Liberali, Mikhail Savitski, Georg Seelig

14 November - 18 November 2022

Genome bioinformatics: resequencing and variant calling

Description A guide to the technology analysis workflows tools and resources for next generation sequencing data analysis This virtual course will provide insights and training into how biological knowledge can be derived from genomics experiments and explain different approaches in analysing such data The main focus will be on introducing sequence informatics re sequencing and variant calling during the analysis of higher eukaryotes with an emphasis on human genetic research Throughout the week more advanced topics will introduce the creation of pipelines automation and the scaling up of analysis experiments Practical sessions will enable participants to process training datasets and apply appropriate statistical methods in their analyses There will be no opportunity to work with personal research data during the course Virtual course Participants will learn via a mix of pre recorded lectures live presentations and trainer Q A sessions Practical experience will be developed through group activities and trainer led computational exercises Live sessions will be delivered using Zoom with additional support and communication via Slack Pre recorded material will be made available to registered participants prior to the start of the course and in the week before the course there will be a brief induction session Computational practicals will run on EMBL EBI s virtual training infrastructure meaning participants will not require access to a powerful computer or install complex software on their own machines Participants will need to be available between the hours of 09 30 18 00 GMT each day of the course Trainers will be available to assist answer questions and further explain the analysis during these times...

Juanita Riveros

13 November - 18 November 2022

Single-cell omics: deeper to genomics

Description OverviewSpeakersProgrammePractical informationSponsors Overview Please see EMBL s COVID 19 safety policy for testing and other requirements to attend this on site course Course overview Single cell sequencing is a rapidly evolving technique and is increasingly implemented in various research fields The whole workflow contains several critical and challenging steps from cell sampling over working with minute amounts of sample to data analysis and integration This hands on course will cover latest cutting edge techniques in single cell genomics Strand Seq single cell multiomics single cell DNTR sequencing during the wet lab practical sessions The computational part will address the basics of data analysing of the above mentioned techniques and also illustrate their integration In addition lectures and discussion rounds with key experts and technology developers in the field will provide the participants with a general background on single cell sequencing technologies and its applications Audience This course targets young scientists entering the field of single cell analysis and wanting to learn about the benefits and limitations of the approach by performing a complete single cell analysis workflow Modules resources Single cell isolation with FACS Single cell genomics using Strand Seq Single cell DNTR sequencing Single cell NGS data analysis Learning outcomes After finishing the course attendees will have an overview of available methods in single cell omics and a basic overview of data analysis of single cell NGS data sets genomics epigenetic and transcriptomics Attendees will also be able to set up some methods in their lab with the knowledge of the detailed protocol and troubleshooting What past participants say about the course This course provided clear guidelines and the latest approaches from researchers who have contributed throughout last years to the single cell field A truly enriching experience for single cell users to get knowledgeable about current methods and their capabilities Melissa Leija Salazar University College London Speakers Speakers trainers and staff Marco Beccuti University of Torino Italy Vladimir Benes EMBL Heidelberg Germany Eva Benito Garagorri EMBL Heidelberg Germany Raffaele Calogero University of Turin Italy Huaitao Cheng Karolinska Institutet Sweden Stephen Clark Altos Labs UK Francesca Cordero University of Torino Italy Qiaolin Deng Karolinska Institute Sweden Martin Enge Karolinska Institute Sweden Eileen Furlong EMBL Heidelberg Germany Karen Grimes Novartis Institute for Biomedical Research NIBR Switzerland Nina Habermann EMBL Heidelberg Germany Patrick Hasenfeld EMBL Heidelberg Germany Wolfram Hoeps EMBL Heidelberg Germany Ashok Kumar Jayavelu KiTZ Hopp Children s Cancer Center Heidelberg Germany Hyobin Jeong Hanyang University Republic of Korea Solrun Kolbeinsdottir Karolinska Institute Sweden Jan Korbel EMBL Heidelberg Germany Diana Ordonez EMBL Heidelberg Germany Mireia Osuna Lopez EMBL Heidelberg Germany David Porubsky University of Washington USA Johan Reimeg rd Uppsala University Sweden Kristina Roucova Charles University Czech Republic Sinem Saka EMBL Heidelberg Germany Ashley Sanders MDC Berlin Germany Anders St hlberg University of Gothenburg Sweden Oliver Stegle German Cancer Research Center Germany Catherine Stober Brasseur EMBL Heidelberg Germany C line Vallot Curie Institute France Laura Villacorta EMBL Heidelberg Germany Thomas Weber EMBL Heidelberg Germany Allan Zhao Karolinska Institute Sweden Scientific organisers Qiaolin Deng Karolinska Institute Sweden Jan Korbel EMBL Heidelberg Germany Anders St hlberg University of Gothenburg Sweden Elisabeth Zielonka EMBL Heidelberg Germany Course organisers Maryann Heck Deputy Head of Course and Conference Office EMBL Heidelberg Germany Irena Provaznikova Training Lab Technician EMBL Heidelberg Germany Aline Schnieder Course Conference Officer EMBL Heidelberg Germany Programme Got something to say Tweet it with EMBOSCOmics Some pre course work such as watching pre recordings protocol reading and computational exercises with estimated time 0 10 hours will be required and will be shared in advance of the course Some speakers may need to join virtually to give their lecture or Q A and the programme is subject to change Day 0 Onboarding session Monday 7 November 2022 Time Europe Berlin SessionLocation10 00 10 15On Boarding Day Welcome and short introductionVirtual10 15 10 45Course overview on eCampus introduction to pre course workVirtual10 45 11 00Questions and TroubleshootingVirtual Day 1 Sunday 13 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus to EMBLISG Hotel09 00 09 30Registration09 30 10 00Welcome and course overviewSession Chair Anders St hlbergFlex Lab A B10 00 11 00Networking activity Flash talksFlex Lab A B11 00 11 30Coffee Break 11 30 12 15Live Q A to pre recorded lecture Introduction to single cell analysis and applications opportunities limitations and standards in the fieldAnders St hlberg University of Gothenburg SwedenFlex Lab A B12 15 13 15LunchEMBL Canteen13 15 14 00Lecture Flow Cytometry and single cell samplingDiana Ordo ez EMBL Heidelberg GermanyFlex Lab A B14 00 15 30Practical work in groups and discussion Group a b Single Cell sampling by FACS Practical session 1 Group c d Interactive session SC genomics and transcriptomics Experimental design discussion round Training Lab B Flex Lab A B FACS15 30 17 00Practical work in groups Group a b DNTR Seq nuclear cytosolic fractionation Practical session 2 Interactive session SC genomics and transcriptomics Experimental design discussion round Group c d Single Cell sampling by FACS Practical session 1 Concurrent coffee breakTraining Lab B Flex Lab A B FACS 17 00 17 30Practical work in groups Group a b Interactive session SC genomics and transcriptomics Experimental design discussion roundGroup c d DNTR Seq nuclear cytosolic fractionation Practical session 2 Concurrent coffee breakTraining Lab B Flex Lab A B FACS 17 30 18 00Coffee break 18 00 18 45Lecture Single cell multi omics simultaneous whole genome and transcriptome analysis by DNTR Seq remote lecture Martin Enge Karolinska Institute SwedenFlex Lab A B18 45 19 30Lecture Single cell analysis in tracking embryo developmentQiaolin Deng Karolinska Institute SwedenFlex Lab A B19 30 21 30Poster session 1 1 8 with pizza and drinksATC Helix B Rooftop Lounge21 30Departure to HotelATC Entrance Day 2 Monday 14 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus to EMBLISG Hotel09 00 09 15Overview of the daySession Chair Anders St hlbergFlex Lab A B09 15 11 55Practical session 3 DNTR Seq Transcriptomics with flexible coffee break Introduction and Reverse transcription set upHuaitao Cheng Karolinska Institutet Sweden Solrun Kolbeinsdottir Karolinska Institutet Sweden Mireia Osuna Lopez EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B Flex Lab A B FACS 11 55 12 55LunchEMBL Canteen12 55 13 25Live Q A to pre recorded lectures Single cell protein analysisSingle cell mass spectrometryAshok Kumar Jayavelu KiTZ Hopp Children s Cancer Center Heidelberg GermanyJohan Reimeg rd Uppsala University SwedenFlex Lab A B13 25 14 25Practical session 3 DNTR Seq TranscriptomicscDNA amplificationHuaitao Cheng Karolinska Institutet Sweden Solrun Kolbeinsdottir Karolinska Institutet Sweden Mireia Osuna Lopez EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B14 25 15 10Lecture Innovations in single cell epigenomics remote lecture Stephen Clark Altos Labs UKFlex Lab A B15 10 15 55Lecture Single Cell ATAC Seq and its ApplicationsEileen Furlong EMBL Heidelberg GermanyFlex Lab A B15 55 17 55Practical session 3 DNTR Seq TranscriptomicscDNA cleanup quantification QCHuaitao Cheng Karolinska Institutet Sweden Solrun Kolbeinsdottir Karolinska Institutet Sweden Mireia Osuna Lopez EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B17 55 19 25Practical session 3 DNTR Seq TranscriptomicscDNA dilution and fragmentation and library PCR set upHuaitao Cheng Karolinska Institutet Sweden Solrun Kolbeinsdottir Karolinska Institutet Sweden Mireia Osuna Lopez EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B19 25 19 35Practical session 3 DNTR Seq TranscriptomicsFollow up QC resultsHuaitao Cheng Karolinska Institutet Sweden Solrun Kolbeinsdottir Karolinska Institutet Sweden Mireia Osuna Lopez EMBL Heidelberg Germany Laura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B19 35 21 00Career networking dinnerEMBL Canteen21 00Departure to HotelATC Entrance Day 3 Tuesday 15 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus to EMBLISG Hotel09 00 09 15Overview of the daySession Chair Qiaolin DengFlex Lab A B09 15 10 15Data Integration on Spatial LevelsOliver Stegle German Cancer Research Centre DKFZ EMBL Heidelberg GermanyFlex Lab A B10 15 10 30Live Q A to pre recorded lecture Imaging based spatial analysis in single cellsSinem Saka EMBL HeidelbergFlex Lab A B10 30 12 30Practical session 4 DNTR Seq GenomicsTn5 digestion and PCR amplification set up barcoding Huaitao Cheng Karolinska Institutet SwedenSolrun Kolbeinsdottir Karolinska Institutet SwedenMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B12 30 13 30LunchEMBL Canteen13 30 15 00Practical session 4 DNTR SeqPooling and library clean upHuaitao Cheng Karolinska Institutet SwedenSolrun Kolbeinsdottir Karolinska Institutet SwedenMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B15 00 15 30Practical session 4 DNTR SeqLibrary QCHuaitao Cheng Karolinska Institutet SwedenSolrun Kolbeinsdottir Karolinska Institutet SwedenMireia Osuna Lopez EMBL Heidelberg GermanyLaura Villacorta EMBL Heidelberg GermanyAllan Zhao Karolinska Institutet SwedenTraining Lab B15 30 16 00Coffee break 16 00 17 30Future in sequencing technologies and Genomics Core Facility TourVladimir Benes EMBL Heidelberg GermanyFlex Lab A B17 30 18 30Live Q A to pre recorded lecture Cancer Omics and Data ScienceJan Korbel EMBL Heidelberg GermanyFlex Lab A B18 30 20 00Poster session 2 9 16 with German Zwiebelkuchen and drinksATC Helix B Rooftop Lounge20 00Departure to HotelATC Entrance Day 4 Wednesday 16 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus to EMBLISG Hotel09 00 09 05Overview of the daySession Chair Eva BenitoFlex Lab A B 09 05 09 50Lecture Single cell genomics using Strand Seq and its applicationsAshley Sanders MDC Berlin GermanyFlex Lab A B09 50 10 50Practical session 5 Strand seq genomicsIntroduction and sample prep nuclei isolation and FACS analysis Eva Benito Garagorri EMBL Heidelberg GermanyKaren Grimes Novartis Institute for Biomedical Research NIBR SwitzerlandPatrick Hasenfeld EMBL Heidelberg GermanyAshley Sanders MDC Berlin GermanyCatherine Stober Brasseur EMBL Heidelberg GermanyTraining Lab B10 50 11 05Coffee break 11 05 12 05Practical session 5 Strand seq genomicssample prep FACS analysis robotics part 1 at FACS machine robotics demoEva Benito Garagorri EMBL Heidelberg GermanyKaren Grimes Novartis Institute for Biomedical Research NIBR SwitzerlandPatrick Hasenfeld EMBL Heidelberg GermanyAshley Sanders MDC Berlin GermanyCatherine Stober Brasseur EMBL Heidelberg GermanyGenecore12 05 13 05Group photo and lunch breakEMBL Canteen 13 05 14 15Practical session 5 Strand seq genomicssample prep FACS analysis gating for StrandSeq Working with real data with FlowJoEva Benito Garagorri EMBL Heidelberg GermanyKaren Grimes Novartis Institute for Biomedical Research NIBR SwitzerlandPatrick Hasenfeld EMBL Heidelberg GermanyAshley Sanders MDC Berlin GermanyCatherine Stober Brasseur EMBL Heidelberg GermanyComputer Training Lab14 20 15 35Practical session 5 Strand seq genomicsMNase digestion with sample clean up with flexible coffee breakEva Benito Garagorri EMBL Heidelberg GermanyKaren Grimes Novartis Institute for Biomedical Research NIBR SwitzerlandPatrick Hasenfeld EMBL Heidelberg GermanyAshley Sanders MDC Berlin GermanyCatherine Stober Brasseur EMBL Heidelberg GermanyTraining Lab B15 35 16 50Practical session 5 Strand seq genomics Library cleanup Eva Benito Garagorri EMBL Heidelberg GermanyKaren Grimes Novartis Institute for Biomedical Research NIBR SwitzerlandPatrick Hasenfeld EMBL Heidelberg GermanyAshley Sanders MDC Berlin GermanyCatherine Stober Brasseur EMBL Heidelberg GermanyTraining Lab B16 50 17 20Coffee break 17 20 19 50Lecture and computational practical 1 Data preprocessing QC imputation normalizationRaffaele Calogero University of Turin ItalyComputer Training Lab19 50Departure to HotelATC Entrance20 00 21 30DinnerISG Hotel Day 5 Thursday 17 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus to EMBLISG Hotel09 00 09 05Overview of the daySession Chair Raffaele CalogeroComputer Training Lab09 05 10 30Computational practical 2 Dimensionality reduction Raffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Marco Beccuti University of Turin Italy Kristina Roucova Charles University Czech RepublicComputer Training Lab10 30 10 45Coffee break 10 45 12 30Computational practical 3 Clustering and depicting cluster specific gene markersRaffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Marco Beccuti University of Turin Italy Kristina Roucova Charles University Czech RepublicComputer Training Lab12 30 13 30Technology lunch with tapasATC Rooftop Lounge13 30 15 00Computational practical 3 Clustering and depicting cluster specific gene markersRaffaele Calogero University of Turin Italy Francesca Cordero University of Turin Italy Marco Beccuti University of Turin Italy Kristina Roucova Charles University Czech RepublicComputer Training Lab15 00 15 15Break 15 15 16 00Lecture and demo Multiomics single cell data analysis DNTR Seq analysisMartin Enge Karolinska Institute SwedenFlex Lab A B16 00 18 30Computational practical 2 DNTR Seq data analysisHuaitao Cheng Karolinska Institute SwedenMartin Enge Karolinska Institute SwedenSolrun Kolbeinsdottir Karolinska Institute SwedenComputer Training Lab18 30 19 30Bus downtown HD free time city centre 19 30 21 30Course dinner downtown Day 6 Friday 18 November 2022 Time Europe Berlin SessionLocation08 40 09 00Bus to EMBLISG Hotel09 00 09 05Overview of the daySession Chair Elisabeth ZielonkaComputer Training Lab09 05 10 35Computational practical 2 DNTR Seq data analysisHuaitao Cheng Karolinska Institute SwedenMartin Enge Karolinska Institute SwedenSolrun Kolbeinsdottir Karolinska Institute SwedenComputer Training Lab10 35 11 20Application Lecture Single cell high throughput Chip Seq analysis in breast cancer tumors remote lecture C line Vallot Curie Institute France FranceFlex Lab A B 11 20 11 50Coffee break 11 50 12 45Computational practicals 3 Single cell genomics data analysis Data visualisation library selection ASHLEYS Karen Grimes EMBL Heidelberg GermanyHyobin Jeong Hanyang Universtiy Republic of Korea Ashley Sanders MDC Berlin Germany Thomas Weber EMBL Heidelberg Germany Wolfram Hoeps EMBL Heidelberg Germany Computer Training Lab12 45 13 45Lunch breakEMBL Canteen13 45 15 50Computational practicals 3 Computational practical Single cell genomics data analysis Strand Seq downstream analysis scTRIP breakpointRKaren Grimes EMBL Heidelberg GermanyHyobin Jeong Hanyang Universtiy Republic of Korea Ashley Sanders MDC Berlin Germany Thomas Weber EMBL Heidelberg Germany Wolfram Hoeps EMBL Heidelberg Germany Computer Training Lab15 50 16 05Coffee break 16 05 17 35Computational practicals 3 continued Single cell genomics data analysis Strand Seq more in depth analysis StrandPhaseR Karen Grimes EMBL Heidelberg GermanyHyobin Jeong Hanyang Universtiy Republic of Korea Ashley Sanders MDC Berlin Germany Thomas Weber EMBL Heidelberg Germany Wolfram Hoeps EMBL Heidelberg GermanyComputer Training Lab17 35 17 50Break 17 50 18 35Lecture remote lecture with Q ADavid Porubsky University of Washington USAFlex Lab A B 18 35 19 05Wrap up and feedbackFlex Lab A B 19 05Departure to Hotel train station 19 15 20 45DinnerISG Hotel Practical information Registration fees and motivation letter The course is limited to 16 participants For selection purposes please note that your application will not be considered without a letter of motivation Registration Registration fees include admission course materials COVID 19 safety measures meals and coffee breaks This EMBO course includes accommodation and transportation to and from the ISG Hotel to the venue Academia 500PhD Student 500Industry 1000 Confirmation and payment The registration fee should be paid only after acceptance to the course The results will be announced approximately 2 3 weeks after the application deadline Motivation letter submission After you have logged in and successfully registered you will receive an email asking you to submit your motivation letter Click on the link provided and enter your motivation letter in the text box provided Alternatively you can submit your motivation letter by clicking on the link on the confirmation page directly after registering Instructions Include your relevant skills experience and qualifications showing why you would be suitable for the course Explain why you would like to attend including what you can contribute and how you think you will benefit from the course Please note The limit of 2000 characters refers to manually typed text and excludes spaces If an error occurs try using a different web browser preferably Google Chrome or Mozilla Firefox If you copy paste the text into the form hidden formatting might still be included which may cause the text to exceed the 2 000 character limit resulting in an error message We recommend you clear all formatting before pasting in the text If you have special symbols in your text make sure you are using Unicode characters otherwise these will not be recognised For more detailed information follow the instructions provided in our video on how to submit a course motivation letter Further details For further information about registration and motivation letter submission please refer to the FAQ page Financial assistance Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants Availability is limited to participants attending on site events in Heidelberg and will be indicated during the abstract or motivation letter submission process Your place in the meeting is only confirmed by paying the registration fee which is mandatory even when receiving a fee waiver Registration fee waiver The fee waiver will cover the registration sum that you have paid to attend the course or conference Travel grant The travel grant will cover the cost of travel airfare train bus taxi accommodation visa and or registration fees and is provided up to specified caps which are normally as follows up to 400 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from within Europe up to 1000 for participants travelling to an EMBL Course EMBL Conference or EMBO EMBL Symposium from outside Europe up to 500 for any participant travelling to an EMBO Practical Course or EMBO Workshop up to 1000 for any participant working in Chile India Singapore or Taiwan travelling to an EMBO Practical Course or EMBO Workshop Registration fees are only covered for EMBO Practical Courses or EMBO WorkshopsThe organisers may reduce the grant cap to accommodate more participants Recipients will be notified of their travel cap amount when they are informed of the outcome of their application Original receipts must be provided with your signature for all costs incurred within two months of completion of travel Scanned copies cannot be accepted Childcare grant EMBO practical courses and workshops only For EMBO Practical Course or EMBO Workshop participants with children there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a course or conference Eligible costs include fees for a baby sitter or child care facility travel costs for a care giver or travel costs for taking the child to the meeting etc Please note that priority will be given to early stage researchers A maximum amount of 500 EUR can be awarded per participant applying for an EMBO Childcare Grant In order to apply for this grant for EMBO Workshops you must be registered by the abstract submission deadline Boehringer Ingelheim fonds travel grant Applies to selected courses only Availability will be indicated during the abstract or motivation letter submission process This grant covers costs related to your attendance to the course registration travel and accommodation costs The grant is restricted to PhD students and postdocs who conduct basic biomedical research Whether you are eligible to apply for a travel grant depends on when you received your university entrance qualification e g Abitur A Levels High School Diploma Final State Examination for PhD and MD students as well as graduates the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course for postdocs the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course Application You may apply for financial assistance when submitting your motivation letter for courses and abstract for conferences In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career Application for financial support will not affect the outcome of your registration application For the Boehringer Ingelheim Fonds Travel Grant there is a pre application question during the motivation letter submission process and if selected you will be requested to complete a standard form and documentation consisting of your travel expense estimation Selection The scientific organisers will select the recipients of all financial assistance during the motivation letter or abstract selection process Results will be announced approximately 6 8 weeks before the event start date however for some events this may be delayed Selection results do not impact your admission to the meeting Selection is based on your current work or study location the reasons for needing financial support and the impact this event will have on your career Reimbursement Costs will be reimbursed after the meeting only once a reimbursement form and original receipts from travel costs have been received Further details View our list of external funding opportunities and information on attending a conference as an event reporter For further information about financial assistance please refer to the FAQ page Accommodation and shuttles Accommodation has been pre booked for you at the ISG Hotel for the default dates of Saturday 12 November to Saturday 19 November 2022 7 nights Please note that the course registration fee includes coverage of accommodation costs in twin rooms including breakfasts for your stay at the ISG If you prefer to stay in a single room please let us know and please note that you will be required to pay an additional cost of 21 EUR per night This should be paid by you directly to the ISG during your stay Any additional nights need to be booked and paid for by you We recommend that all course participants stay at the ISG Hotel which is the dedicated hotel for the course Local transport Shuttle buses will go from the ISG Hotel to EMBL and back mornings and evenings A bus schedule and location of the bus stops will be made available prior to the meeting Further details Address EMBL Heidelberg Meyerhofstra e 1 69117 Heidelberg GermanyFor further information on getting to EMBL Heidelberg visit our Travel Information page For enquiries about accommodation and local transportation please refer to the FAQ page Technical requirements and event software Event software The EMBL eCampus learning platform will be used to collaborate communicate and network with all of the course participants All participants will receive information on how to join shortly before the course We recommend using Chrome Safari or Mozilla Firefox browsers for eCampus Additional information Please find additional information including FAQs terms and conditions COVID 19 safety policy and travelling to EMBL on our Information for Participants page COVID 19 related questions COVID 19 information for on site events at EMBL Heidelberg can be found in our COVID 19 FAQs Sponsors Sponsorship opportunities We offer a variety of event sponsoring possibilities with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget Discounts are available for companies sponsoring multiple events at EMBL Heidelberg View other conferences or contact sponsorship embl de for further information If you are interested in becoming a media partner of this event please visit our media partnerships webpage...

Qiaolin Deng, Jan O. Korbel, Anders Ståhlberg, Elisabeth Zielonka

10 November 2022

Modular and reproducible workflows for federated molecular QTL analysis

Description Genetic analysis of molecular traits such as gene expression splicing and chromatin accessibility requires a number of complex analysis steps that can easily take weeks or months for an analyst to implement from scratch In the CINECA project we have developed a number of modular Nextflow workflows that standardise and automate these steps In this webinar we will give an overview of the CINECA workflows for genotype imputation gene expression and splicing quantification data normalisation and association testing and demonstrate how these workflows can be used in a federated setting without transferring identifiable personal data between partners The CINECA Common Infrastructure for National Cohorts in Europe Canada and Africa project aims to develop a federated cloud enabled infrastructure to make population scale genomic and biomolecular data accessible across international borders to accelerate research and improve the health of individuals across continents About the speaker Kaur Alasoo is a Lecturer of Bioinformatics at the University of Tartu His research is focussed on genetic analysis of diverse molecular traits and building data resources to facilitate secondary use of molecular QTL datasets Kaur is also a co lead of the eQTL Catalogue project...

9 November 2022

Improving data reproducibility for chemosensitivity assays using MICHA

Description Chemosensitivity assays are commonly used for preclinical drug discovery and clinical trial optimisation However poor inter and intra laboratory reproducibility has been reported largely attributed to uncharacterised variation in the assay protocols Central to improving the data reproducibility is the standardisation of assay ontologies using minimal information MI To facilitate the open data in chemosensitivity assays we have launched MICHA minimal information for chemosensitivity assays available at http micha protocol org MICHA is an integrative pipeline to annotate chemosensitivity assays based on four major components including 1 compounds 2 samples 3 reagents and 4 data processing references This webinar will demonstrate how MICHA can automatically extract publicly available information for compounds including primary and secondary targets disease indications and physio chemical properties Users may next fill in the annotations including cell line or patient clinical variables assay types detection technologies and other experimental parameters Finally a tabular report can be generated to include the annotation results for the users to download In addition users may also browse the catalogue of drug sensitivity assay protocols which were already FAIRified by MICHA Using the platform of MICHA we aim to increase acceptance and adoption of the principles of FAIR Findable Accessible Interoperable and Reusable by making the assay annotation as smoothly as possible This webinar will showcase the utility of MICHA including FAIRified protocols from several major cancer drug screening studies including CCLE CTRP GDSC as well as recently conducted COVID 19 drug screening studies...

Jing Tang

8 November - 9 November 2022

Bioinformatics tools and data retrieval

Description The Job Dispatcher service at the EMBL EBI provides access to various sequence analysis tools and a database retrieval system Dbfetch This virtual course is split into two sessions running over two days During the first session you will learn how to access and use our sequence analysis tools Eg NCBI BLAST Clustal Omega EMBOSS and retrieve various database entries at the EMBL EBI using Dbfetch This session will also explain how to use sequence alignment and search effectively to find relevant results The second session focuses on alternative ways to access these services beyond the website This session will introduce the Job Dispatcher RESTful API show how to access our tools programmatically and integrate them into workflows...

Nandana Madhusoodanan