University of California, San Diego
This conference will take place at EMBL Heidelberg, with the option to attend virtually. Please see EMBL’s COVID-19 safety policy for testing and other requirements if attending the on-site event.
There is an increasing awareness that mechanistic structural information on molecular machines is ideally generated within the context of intact cells in order to fully grasp how they function in a complex native environment. Recent technological advances have nurtured the development of such in situ structural biology approaches in several disciplines, including cryo-EM, mass spectrometry, super-resolution microscopy, NMR, computational modelling and others.
This conference will bring together experts and early stage researchers from the separate fields
“The conference was fantastic, with an amazing list of speakers. As an early career researcher I found these events very inspirational and broadening for research opportunities later.” Kamila Kamuda, University College London, UK
“I immensely benefited from the workshop organized by EMBL through talks of so many brilliant scientists who had explained the fast-evolving technique to capture the whole cell structure at the near-atomic resolution.” – Samar Ballabha Mohapatra, Indian Institute of Technology, India
University of California, San Diego
Max Planck Institute of Biochemistry
Research Institute of Molecular Pathology (IMP)
SLAC National Accelerator Laboratory
University of Basel
University of Cologne
University of California, San Diego
University of Utah
University of Pennsylvania
Leibniz-Forschungsinstitut for Molecular Pharmacology (FMP)
UMass Chan Medical School
University of California, Berkeley
Niels Bohr Institute
Max Delbrück Center for Molecular Medicine
Allen Institute for Cell Science
The Hebrew University of Jerusalem
Weizmann Institute of Science
HHMI Janelia Research
University of Oxford
Max Planck Institute of Biophysics
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|11:30 – 13:00||Registration and light refreshments|
|13:00 – 13:15||Opening remarks by scientific organisers|
|13:15 – 14:00||Keynote|
Rommie Amaro – University of California, USA
Introduced by Jan Kosiski
|14:00 – 17:00||Session 1: in situ cryo-EM|
Session chair: Julia Mahamid
|14:00 – 14:25||In situ multi-scale structural analysis of virus infection by cellular cryo-tomography|
Peijun Zhang – University of Oxford, UK
**Live stream only**
|14:25 – 14:40||Cryo-electron tomography and deep learning denoising reveal native chromatin landscapes of interphase nuclei|
Mikhail Elfsov – IGBMC, France
|14:40 – 14:55||Plate-like guanine biocrystals form via templated nucleation of crystal leaflets on preassembled scaffolds|
Zohar Eyal – Weizmann Institute of Science, Israel
|14:55 – 15:40||Coffee Break and Meet the speakers|
|15:40 – 16:05||Visualizing ribosome biogenesis in cells with 2DTM|
Bronwyn Lucas – University of Massachusetts, USA
|16:05 – 16:20||Enabling discovery with in-cell cryo-ET & alphaFold: identification of a novel translocation complex|
Rasmus Jensen – EMBL Heidelberg, Germany
|16:20 – 16:35||Structural insight into the Ebola virus nucleocapsid assembly cascade by in-cell cryo-correlative light and electron microscopy|
Melina Vallbracht – Heidelberg University Hospital, Germany
|16:35 – 17:00||Exploring photosynthesis and carbon fixation across scales with cryo-electron tomography|
Ben Engel – University of Basel, Switzerland
|17:00 – 17:40||Flash talks|
#46 – Gülberk Bayraktar, #48 – Tiana Behr, #52 – Daksh Daksh, # 60 – Chinenye Ekemezie, #74 – Andreja Kezar, # 77 – Matthew Lycas, #82 – Evangelia Nathanail, #84 – Alexander Rau, #85 – Karolina Roganowicz, #89 – Simon Schaefer, #94 – Eva Maria Soriano Jerez, #95 – Marie-Christin Spindler, #97 – Reiya Taniguchi, #102 – Renjing Wang, #103 – Helena Watson, #106 – Davide Zabeo, #110 – Michael Zimmermann,
|17:40 – 19:00||Dinner in Canteen|
|19:00 – 20:30||Welcome reception and tour of Imaging Centre|
|08:15 – 09:15||Arrival|
|09:15 – 12:00||Session 2: Advances in super-resolution light microscopy|
Session chair: Suliana Manley
|09:15 – 09:40||Visualizing the inner life of cells with super-resolution microscopy|
Melike Lakadamyali – University of Pennsylvania, USA
|09:40 – 09:55||4Pi-STORM visualization of nuclear pore complex architecture|
Mark Bates – Institute for Nanophotonics, Germany
**Live stream only**
|09:55 – 10:10||Visualization of loop extrusion by nanoscale 3D DNA tracing in single human cells|
Kai Beckwith – EMBL Heidelberg, Germany
|10:10 – 10:40||Coffee Break and Meet the speakers|
|10:40 – 11:05||Accessing nanoscale structure and dynamics with light|
Francisco Balzarotti – Research Institute of Molecular Pathology, Austria
**Live stream only**
|11:05 – 11:20||Toward correlative cryogenic super-resolution light and electron microscopy|
Hisham Mazal – Max Planck Institute, Germany
|11:20 – 11:35||Superresolution microscopy reveals partial preassembly and subsequent bending of the clathrin coat during endocytosis|
Aline Tschanz – EMBL Heidelberg, Germany
|11:35 – 12:00||Bringing light to mitochondrial apoptosis|
Ana Garcia-Saez – University of Cologne, Germany
**Live stream only**
|12:00 – 13:30||Lunch, including job fair.|
|13:30-16:30||Session 3: Modeling across scales|
Session chair: Rommie Amaro
|13:30 – 13:55||Integrative structure modeling of protein complexes in the age of deep learning |
Dina Schneidman-Duhovny – The Hebrew University of Jerusalem, Israel
|13:55 – 14:10||Towards visual proteomics: In-situ detection of macromolecular complexes by high-resolution template matching|
Sergio Cuz-Leon – Max Planck Institute of Biophysics, Germany
|14:10 – 14:25||Combining computation and microscopy to reveal mechanisms in bacterial transport machines|
Angela Kirykowicz – University of Cambridge, UK
|14:25 – 15:10||Coffee break and meet the speakers|
|15:10 – 15:35||Computational microscopy of biomembrane shapes|
Weria Pezeshkian – Niels Bohr Institute, Denmark
|15:35 – 15:50||Predicting lipid-protein interactions in the age of integrative structural biology|
Stefano Vanni – University of Fribourg, Switzerland
|15:50 – 16:05||Validation of integrative structures in PDB-Dev based on SAXS, CX-MS, and 3DEM data|
Arthur Zalevsky – University of California, USA
|16:05 – 16:30||Animating Data-Rich Molecular Mechanisms |
Janet Iwasa – University of Utah, USA
|16:30 – 17:05||Flash talks|
#54 – Sofia De Felice, #55 – Takahiro Deguchi, #67 – Jan Philipp Kreysing, #69 – Nazia Hussain, #79 – Johannes Rudolph, #87 – Jenny Sachweh, #101 – Christian Tueting, #109 – Liv Zimmermann, #47 – Paul Becker, #49 – Harald Bernhard, #51 – Cristina Capitanio, #93 – Deniz Daviran, #57 – Joe Dobbs, #61 – Bronwen Foster, #73 – Mukthi Iyer
|17:00 – 18:30||Poster Session 1 (odd) with beer and snacks|
The poster listing can be found here
|18:30 – 20:00||Dinner in Canteen|
|20:00 – 22:00||Pub Quiz and social drinks|
|08:15 – 09:15||Arrival|
|09:15 – 12:00||Session 4: Emerging technologies|
Session chair: Martin Beck
|09:15 – 09:40||What in-cell NMR can teach us about intracellular protein structures and dynamics.|
Phil Selenko – Weizmann Institute of Science, Israel
|09:40 – 09:55||Live-cell imaging and integrative modeling to explore the functionality of protein assemblies|
Altair Chinchilla Hernandez – Pompeu Fabra University, Spain
|09:55 – 10:10||Cryo-EM snapshots of eukaryotic membrane proteins in native lipid-bilayer nanodiscs|
Kevin Janson – Martin Luther University Halle-Wittenberg, Germany
|10:10 – 10:40||Coffee Break and meet the speakers|
|10:40 – 11:05||Integrated intracellular organization and its variations in human iPS cells |
Susanne Rafelski – Allen Institute for Cell Science
|11:05 – 11:20||Linking cellular ultrastructure to gene expression with correlative cryo-ET/scRNA-seq|
Andre Schwarz – Max Planck Institute for Brain Research, Germany
|11:20 – 11:35||Exploiting OMVs for the in-situ characterization of bacterial envelope proteins|
Johannes Thoma – University of Gothenburg, Sweden
**live stream only**
|11:35 – 12:00||Protein structures in context with proteome-wide biophysics|
Ilaria Piazza – Max Delbrück Center for Molecular Medicine, Germany
**Live stream only**
|12:00 – 13:30||Lunch|
|13:30-16:45||Session 5: Instrumentation|
Session chair: Jurgen Plitzko
|13:30 – 14:15||Keynote |
The long and winding road to in situ structural biology with cryo-ET
Juergen Plitzko – Max Planck Institute of Biochemistry, Germany
Introduced by: Julia Mahamid
|14:15 – 14:30||Plasma FIB milling for the determination of structures in situ|
Casper Berger – Rosalind Franklin Institute, UK
|14:30 – 14:45||Cryo-FIB milling and cryo-ET of vertically trapped, dividing E. coli bacteria|
Victoria Hale – MRC Laboratory of Molecular Biology, UK
|14:45 – 15:30||Coffee Break and Meet the speakers|
|15:30 – 15:55||Dynamics of molecules at the nanoscale with photo-switching |
Ilaria Testa – SciLifeLab, Sweden
|15:55 – 16:20||Super-resolved cryogenic correlative light and electron microscopy: Specific labelling with cellular context|
Peter Dahlberg – Stanford, USA
|16:20 – 16:45||Laser phase plate: Advancing beyond proof-of-concept|
Holger Müller – University of California, Berkeley, USA
|16:45 – 17:20||Flash talks|
#44 – Milan Aleksic #56 – Natalie Diepenhorst, #58 – Wioleta Dudka, #62 – Herman Fung, #66 – Miguel Hernandez Gonzalez, #76 – Sven Klumpe, #68 – Neil Mcdonald, #83 – Alessandro Passera, #86 – Max Ruwolt, #88 – Veijo Salo, #92 – Ioannis Skalidis, #96 – Frosina Stojanovska, #100 – Zuzana Trebichalská, #104 – Yu-Le Wu, #108 – Christian Zimmerli
|17:20 – 18:45||Poster Session 2 (even) with beer and snacks|
The poster listing can be found here
|18:45 – 20:15||CONFERENCE DINNER in the canteen|
|20:15 – 22:45||Live music|
|08:15 – 09:15||Arrival|
|09:15 – 12:30||Session 6: Across scales|
Session chair: Philipp Selenko
|09:15 – 09:40||Developing structural interactomics and its application in cell biology|
Fan Liu – Leibniz-Forschungsinstitut for Molecular Pharmacology, Germany
|09:40 – 09:55||Integrative structural studies of thyroid homeostasis: a first look into cellular and organoids organisation|
Francesca Coscia – Human Technopole, Italy
|09:55 – 10:20||Towards automated segmentation in volume electron microscopy|
Aubrey Weigel – Institute of Genetics and Molecular and Cellular Biology, USA
|10:20 – 10:50||Coffee Break and Meet the speakers|
|10:50 – 11:05||Bacterial nano-compartments, their function in metal homeostasis and role in the cellular response mechanisms against stress|
Célia Maria Romão – Universidade Nova de Lisboa, Portugal
|11:05 – 11:20||How influenza A virus solves the nuclear escape room|
Daniel Ziemianowicz – EMBL Hamburg, Germany
|11:20 – 11:45||Building a mind for cancer|
Trey Ideker – University of California, USA
|11:45 – 12:30||Round table discussion|
|12:30 – 12:45||Closing remarks and poster prize|
On-site registration fees include admission, conference materials, COVID-19 safety measures, meals and coffee breaks. Participants are expected to book and pay their own accommodation and travel expenses.
Virtual registration fees include access to all of the talks (livestreamed and on demand) and facility to submit questions.
|On-site PhD Student||€350|
|Virtual PhD Student||€125|
NO visa support letters will be issued until payment of the registration fee is confirmed.
Accredited journalists may be eligible to register for a reduced press rate or in some cases for complimentary registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Christopher Stocks for more information. Please note that we do not offer complimentary registrations for editors of scientific journals.
Registration will be on a first-come first-served basis. Your place can only be confirmed after payment of the registration fee. If you are added to our waiting list, please consider taking advantage of our offerings to participate virtually.
On-site participants: Types of payments accepted are international bank transfers and credit card payments.
Virtual participants: We are only able to accept card payments. In exceptional cases we can accept bank transfers. Please contact firstname.lastname@example.org for details.
Only participants registering to attend the on-site event are eligible to submit an abstract. Abstracts will not be accepted from virtual participants.
After registration you can submit your abstract via a separate link that will be provided in the email confirmation. Alternatively, you can access the link on the confirmation page directly after registering. The same login credentials are used for both processes.
Abstract body: The limit of 2000 characters refers to manually typed text and excludes spaces. If an error occurs try using a different web browser (preferably Google Chrome or Mozilla Firefox).
If you copy-paste the text into the form, hidden formatting might still be included which may cause the text to exceed the 2,000 character limit resulting in an error message. We recommend you clear all formatting before pasting in the text.
If you have special symbols in your text, make sure you are using Unicode characters, otherwise these will not be recognised.
Title: The title should not exceed 20 words. Only the first word of the title should start with a capital letter and the rest should be lowercase.
Authors and affiliations: Please fill in the author’s details as requested in the online form. The compulsory fields are: First Name, Last Name, Organisation Name (Affiliation or Company), Country and Email.
Kindly mark only one author in the role of First Author and please don’t forget to indicate who will be the Presenter.
Please enter your co-authors correctly via the system by adding accounts together with their organisation/institute. Do not copy-paste them into the body of the abstract text, as they will not be indexed in the abstract book.
Presentation types: When submitting your abstract, you can apply for an oral or poster presentation. A selection process will take place with the results announced 2-3 weeks after the abstract submission deadline.
For detailed instructions on how to submit a conference abstract, follow the instructions provided in this video.
Please check our FAQs pages for further information on how to submit an abstract.
Limited financial assistance is provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO in the form of both registration fee waivers and travel grants. These are available for on-site participants at EMBL Conferences and EMBO|EMBL Symposia, and for on-site and virtual participants at EMBO Workshops. We are currently working on securing funding for all virtual participants, and ask that you please apply for financial assistance for both on-site and virtual participation.
Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.
The fee waiver will cover the registration sum that you have paid to attend the course or conference.
The travel grant will cover the cost of travel to an on-site event (airfare, train, bus, taxi, accommodation, visa, and/or registration fees*) and is provided up to specified caps which are normally as follows:
–up to €400 for participants travelling to an EMBL Conference or EMBO|EMBL Symposium from within Europe.
–up to €1000 for participants travelling to an EMBL Conference or EMBO|EMBL Symposium from outside Europe.
–up to €500 for any participant travelling to an EMBO Workshop.
–up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Workshop.
–up to €700 for any participant working in Croatia, Czech Republic, Estonia, Greece, Hungary, Italy, Lithuania, Luxembourg, Poland, Slovenia, and Turkey travelling to an EMBO Workshop.
*Registration fees are only covered for EMBO Workshops
The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel. Scanned copies cannot be accepted.
For EMBO Workshop participants with children, there is the possibility to apply for a childcare grant to offset child care costs incurred by participants or speakers when participating at a conference. Eligible costs include fees for a baby-sitter or child-care facility, travel costs for a caregiver, or travel costs for taking the child to the meeting etc. Please note that priority will be given to early stage researchers. A maximum amount of €500 can be awarded per participant applying for an EMBO childcare grant. In order to apply for this grant for EMBO Workshops, you must be registered by the abstract submission deadline.
You may apply for financial assistance when submitting your abstract. In your application you will be asked to answer questions regarding why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.
If you are attending virtually, you can apply for financial assistance in the submission portal by the abstract deadline. Read the instructions on how to apply for financial assistance. Only submissions for financial assistance will be accepted. Presentation abstracts cannot be submitted here and will be declined.
In your application you will be asked to summarise your current work, answer questions regarding why your lab cannot fund your attendance, and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.
The scientific organisers will select the recipients of all financial assistance during the abstract selection process. Results will be announced approximately 6 – 8 weeks before the event start date, however for some events this may be delayed. Selection results do not impact your admission to the meeting. Selection is based on scientific merit, your current work or study location, the reasons for needing financial support, and the impact this event will have on your career.
Costs will be reimbursed after the meeting only once a reimbursement form and original receipts (from travel costs) have been received.
For further information about financial assistance please refer to the FAQ page.
Accommodation is not included in the conference registration fee.
As further changes in our events are possible due to COVID-19, you should book flights, trains and hotels with flexible options and favourable cancellation conditions.
|Hotel Anlage||Hotel ibis Heidelberg||Premier Inn Heidelberg City|
|Hotel Bayrischer Hof||ISG Hotel||Staycity Aparthotel Heidelberg|
|B&B Hotel||Leonardo Hotel Heidelberg City Centre||Steffi’s Hostel Heidelberg|
|Exzellenz Hotel||Meininger Heidelberg||Hotel Vier Jahreszeiten Heidelberg|
|Hotel Holländer Hof||Hotel Monpti|
Conference shuttle buses are free of charge for participants, and depart from designated bus stops near the hotels to EMBL and back, mornings and evenings.
The bus stops for this conference are:
View Conference shuttle bus stops and hotels in a larger map. Please note that not every bus stop will be used for every event.
Download the conference bus schedule here. If you miss the bus you can call a taxi at +49 6221 302030
Address: EMBL, Meyerhofstraße 1, 69117 Heidelberg, Germany. For further information on getting to EMBL Heidelberg visit Public Transportation to the Venue. For information about accommodation and local transportation please refer to the FAQ page.
All meals and coffee breaks are included in the registration fee. Our catering staff will prepare a wide variety of vegetarian meals, meat and fish dishes, soups, pasta, fresh fruit and vegetables, as well as a variety of desserts.
Please wear your badge at all times when serving yourself.
No food or drinks are allowed in the auditorium.
There are lockers available next to the stairs leading down into the Auditorium. You will find some of those equipped with sockets to charge your smartphone/tablet etc.
In most places the electricity is 220 volts AC (50 cycles). An adaptor and a plug that fits the German socket may be needed for your appliances/laptop (i.e. American, Japanese, etc.). A USB charging station for electronic devices is available at the registration desk.
If you are interested in purchasing an EMBL souvenir (products presented in the glass display in the registration area), please ask at the registration desk for more information.
Please read EMBL’s COVID-19 safety policy for on-site events.
Do not smoke in any EMBL building.
Eating and drinking is prohibited in the Auditorium and all laboratories.
Do not enter any restricted areas or the laboratories unless instructed to do so.
If first aid is required …
In case of fire …
Beyond first aid…
Please remember to bring your own medication, if needed, to the conference. Note that the next pharmacy is a 4-minute drive from the EMBL, but for many medications you will be required to see a doctor to get a prescription.
Ensure in advance that your medical insurance will cover you during your visit in the event that you do need to see a doctor while in Heidelberg. In any case, the EMBL Course and Conference Office will assist you to get to the pharmacy and a doctor of your choice if necessary.
Wi-Fi is available everywhere on the premises (no password required), just log on to ATC-Guest. The eduroam network (secure, world-wide roaming access service developed for the international research and education community) is also available.
‘’Lost and Found’’ are kept at the registration desk until the end of the conference.
There are lockers available on-site to store your luggage, which require a 2 EURO coin to operate. There is another luggage room on level E0, which is free to use but remains unlocked during the conference.
There is a nursing room available in the ATC Rooftop Lounge on level A29.
During the conference an EMBL Photographer may be taking photographs. If you would not like to appear in these, please inform the photographer or a member of the Course and Conference Office.
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There is a room for prayer, mediation and yoga located on level E0 behind the Auditorium. Please be respectful of other participants using the room.
During the event we provide conference shuttle buses to and from EMBL. In addition, there is the public bus 39A that serves the EMBL campus and taxis can be easily booked at any time. Information on the conference shuttle buses can be found on the individual event website and more detailed information on travelling to EMBL can be found on our Travel Information page.
|Good morning||Guten Morgen|
|Good afternoon||Guten Tag|
|Good evening||Guten Abend|
|Good night||Gute Nacht|
|I’m sorry||Tut mir leid|
|Excuse me…||Entschuldigen Sie|
|How are you?||Wie gehts?|
|I’m fine thanks. And you?||Mir geht es gut , danke, und dir/Ihnen?|
|What is your name||Wie heisst du? Wie heissen Sie?|
|My name is||Ich heisse|
|Do you speak English||Sprechen Sie Englisch?|
|I don’t understand||Ich verstehe nicht|
|Please speak more slowly||Können Sie bitte langsamer sprechen|
|Where is the toilet?||Wo ist die Toilette?|
|Please call me a taxi||Bitte rufen Sie mir ein Taxi|
|How do I get to….?||Wie komme ich zum/zur…..?|
|A beer/two beers please||Ein Bier/zwei Bier bitte|
|A glass of red/white wine please||Ein Glas Rot/Weisswein bitte|
|The menu, please||Die Speisekarte, bitte|
|Is there a local speciality?||Gibt es eine Spezialität aus dieser Gegend?|
|I’m Vegetarian||Ich bin Vegetarier|
|It was delicious||Es war hervorragend|
|The bill, please||Die Rechnung, bitte|
|I have a headache||Ich habe Kopfschmerzen|
|I have a sore throat||Ich habe Halsschmerzen|
|My stomach hurts||Ich habe Magenschmerzen|
|I’m allergic to||Ich bin allergisch gegen|
|I need a doctor who speaks English||Gibt es einen Arzt, der Englisch spricht?|
Please note that only on-site participants are able to submit abstracts and participate in the poster sessions.
We are using an event platform for this conference. More information about the platform will be shared ahead of the conference.
Additional information can be found in our Code of Conduct.
It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the conference platform for you to enjoy during the event.
Please use the Q&A function in the event platform.
If you have any other questions, you can go to the Help Desk in the event platform. Click on ‘more’ on the top menu and click Help Desk.
The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. Please take your time zone into consideration when planning your attendance.
Please find additional information including FAQs, terms and conditions, COVID-19 safety policy and travelling to EMBL on our Information for Participants page.
COVID-19 information for on-site events at EMBL Heidelberg can be found in our COVID-19 FAQs.
We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact firstname.lastname@example.org for further information on sponsoring possibilities.
If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.
Want to let others know you’re attending this event? Take a look at our shareable media and feel free to use them in your social media channels or presentations.
Date: 8 - 11 Feb 2023
Location: EMBL Heidelberg and Virtual
Venue: EMBL Advanced Training Centre
Abstract submission: Closed
Registration (On-site): Closed
Registration (Virtual): Closed