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Multiomics to Mechanisms: Challenges in Data Integration – Course and Conference Office

EMBO | EMBL Symposium

Multiomics to Mechanisms: Challenges in Data Integration

Overview

EMBO and EMBL are committed to sharing research advances and sustaining scientific interaction throughout the coronavirus pandemic. We are delighted to announce that the conference is going virtual and invite you to join us online. The virtual conference includes talks from invited speakers, short talk presenters, online group discussions and networking opportunities.

Symposium Overview

The current speed at which high-throughput data are produced and the growing number of studies that use not only one but multiple omics technologies on the same samples offers tremendous opportunities for enhancing our molecular understanding of biological systems. One of the biggest challenges in the era of multiomics is the integration and interpretation of the diverse large-scale omics data in a way that provides biological insights. This requires the development of statistical, mathematical and computational tools and – equally important – experimental strategies to follow up on hypotheses generated by large-scale data. Together, these computational and experimental tools will enable us to address novel questions and identify biological mechanisms.

This is the third in series of EMBL | EMBO symposia focusing on challenges and opportunities in data integration. Our goal is to provide a platform for discussing and presenting strategies for multiomics data integration that go beyond descriptive analyses and aim towards mechanistic, biological interpretation. For this we are inviting scientists from different fields that share their enthusiasm for integrating multi-modal data to understand biological systems. Traditionally, the audience of the meeting has been very diverse in terms of biology, yet very united in their interest in discussing about how to integrate and learn from data. Presenters are therefore asked to specifically highlight the integrative aspect of their work and how it helped in understanding biology.

Session Topics

  • Novel high-throughput technologies
  • Statistical methods for data integration
  • Computational tools for data integration
  • Multiomics in single cells
  • Applications of multiomics
  • Applications of metabolomics
  • Applications of proteomics
  • Applications of genomics
  • Mechanistic studies to follow up omics studies

Speakers

Edda Klipp

Humboldt Universität zu Berlin

Germany

Katie Pollard

Gladstone Institutes and University of California, San Francisco

USA

Scientific Organisers

Conference Officers

Nathalie Sneider

EMBL Heidelberg

Germany

Maria Mercedes Bacadare Goitia

Course and Conference Manager

EMBL Heidelberg

Germany

Programme

Got something to say? Tweet it! #EESOmics

  • The virtual conference includes live-streamed invited speaker talks and live-streamed selected short talks with live Q&A sessions after each talk as well a panel discussion each day and meet the speaker sessions.
  • All digital poster presenters are encouraged to upload a recorded flash talk or narration with their digital poster and to schedule video calls during poster session times.
  • Information on the live stream and access to the discussion platform and digital posters will be provided 1 week before the start of the event.
  • Pre-recorded talks (160 minutes in total) will be made available 1 week before the start of the conference. Presenters of pre-recorded talks will be attending the Meet the Pre-recorded Short Talk Speaker sessions that will take place in parallel with the Day 1 and Day 2 Poster Sessions. Please watch the pre-recorded talks beforehand so that you can ask your questions/discuss the talk.
  • Access to the recorded talks will be available for 2 weeks after the end of the event.

All times in the programme below are shown as the time in Europe/Berlin.

To find out the equivalent time zone in your location, enter Berlin, the programme time and date along with your city into the Time Zone Converter.

Day 1 – Wednesday 15 September 2021
TimeSpeaker
15:00 – 15:10 Opening remarks
15:10 – 18:20Session 1
Chairs: Evangelia Petsalaki and Judith Zaugg
15:10 – 15:35Dissecting the regulation of hematopoiesis by lineage tracing and single-cell omics
Thomas Höfer – German Cancer Research Center, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:35 – 15:50High-throughput metabolome profiling predicts novel TOR signaling-related genes
Duncan Holbrook-Smith – ETH Zürich, Switzerland
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:50 – 16:15The Ups and Downs of Protein Expression Regulation
Christine Vogel – New York University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:15 – 16:30Multiomics landscape of the ageing human mesenchymal stromal cells
Mang Ching Lai – EMBL Heidelberg, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:30 – 16:45Break
16:45 – 17:10To bin or not to bin: analyzing single-cell growth data
Ariel Amir – Harvard University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:10 – 17:25Signature Regulatory Clustering (SiRCle) model to understand cancer regulation through semi-supervised integration
Christina Schmidt – University of Cambridge, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:25 – 17:50Sequence-structure-function modeling for DNA
Katie Pollard – Gladstone Institutes and University of California, San Francisco, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:50 – 18:15Genotype to phenotype mapping of tumorigenesis at single cell resolution
Christina Curtis – Stanford University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
18:15 – 18:50Break
18:50 – 19:50Virtual Poster Session 1 (A-L) and
Meet the Pre-recorded Short Talk Speakers (A-M)
19:50 – 20:35Panel Discussion Day 1
Chairs: Evangelia Petsalaki and Judith Zaugg

Panelists
Ariel Amir – Harvard University, USA
Christina Curtis – Stanford University, USA
Thomas Höfer – German Cancer Research Center, Germany
Katie Pollard – Gladstone Institutes and University of California, San Francisco, USA
Christine Vogel – New York University, USA
20:35 – 20:40Transition to Meet the Speakers Day 1 
20:40 – 21:10Meet the Speakers Day 1
Ariel Amir, Christina Curtis, Thomas Höfer, Katie Pollard, Christine Vogel and short talk speakers Duncan Holbrook-Smith, Mang Ching Lai, Christina Schmidt
21:10 – 21:15Transition over to Virtual Speed Networking
21:15 – 22:00Social programme: Virtual speed networking

Digital posters and pre-recorded talks as well as discussion channels will be available for registered participants throughout the whole virtual meeting.

Day 2 – Thursday 16 September 2021
TimeSpeaker
14:30 – 15:00Social programme: Meet other participants in the Social Lounge and chat ahead of the day’s talks (link available in the conference platform)
15:00 – 18:05Session 2
Chairs: Edda Klipp and Nevan Krogan
15:00 – 15:25 Chromatin conformation during early embryonic development
Juanma Vaquerizas – MRC London Institute of Medical Sciences, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:25 – 15:40The pathobiology of Mycobacterium abscessus revealed through phenogenomic analysis
Lucas Boeck – University of Basel, Switzerland
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:40 – 16:05Harnessing big data for personalized medicine
Eran Segal – Weizmann Institute of Science,
Israel
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:05 – 16:20Computational pharmacogenomics identifies synergistic statin-compound combinations that target the mevalonate pathway for breast cancer treatment
Deena Gendoo – University of Birmingham, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:20 – 16:35Break
16:35 – 17:00Incorporating proteome constraints in genome-scale metabolic models
Bas Teusink – Vrije Universiteit Amsterdam, The Netherlands
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:00 – 17:15Uncovering molecular-aging trajectories in budding yeast through multidimensional proteomics
Mario Leutert – University of Washington, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:15 – 17:40Mechanistic insights into functional effects of point mutations at the systems level
Tanja Kortemme – University of California, San Francisco, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:40 – 18:05Integration of constraint-based models and metabolomics to elucidate tumor-stromal crosstalk in colorectal cancer
Stacey Finley – University of Southern California, San Francisco, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
18:05 – 18:35Break
18:35 – 19:35Virtual Poster Session 2 (M-Z) and
Meet the Pre-recorded Short Talk Speakers (N-Z)
19:35 – 20:20Panel Discussion Day 2
Chairs: Edda Klipp and Nevan Krogan

Panelists:
Stacey Finley – University of Southern California, San Francisco, USA
Tanja Kortemme – University of California, San Francisco, USA
Juanma Vaquerizas – Max Planck Institute for Molecular Biomedicine Muenster, Germany
20:20 – 20:25Transition to Meet the Speakers Day 2
20:25 – 20:55Meet the Speakers Day 2
Stacey Finley, Tanja Kortemme, Juanma Vaquerizas and short talk speakers Lucas Boeck, Deena Gendoo, Mario Leutert
20:55 – 21:00Transition over to Living Room Concert (followed by Bar Mixer)
21:00 – 22:00Social programme:
Living Room Concert with Lazy Fur (30 minutes) followed by Bar Mixer (30 minutes)

Digital posters and pre-recorded talks as well as discussion channels will be available for registered participants throughout the whole virtual meeting.

Day 3 – Friday 17 September 2021
TimeSpeaker
15:00 – 18:40Session 3
Chairs: Thomas Höfer and Uwe Sauer
15:00 – 15:25 Identification of phenotype-specific networks from paired gene expression-cell shape imaging data
Evangelia Petsalaki – EMBL-EBI Hinxton, UK
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:25 – 15:40Integrated multi-omic analysis of a rare inborn error of metabolism
Patrick Forny – University Children’s Hospital, Zurich
AVAILABLE ON DEMAND AFTER LIVE STREAM
15:40 – 16:05Molecular function of chromatin regulators linked to neurodevelopmental disorders
Kyung-Min Noh – EMBL Heidelberg, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:05 – 16:20 Break
16:20 – 16:45Understanding a life – integration of time-resolved population and single cell data for a yeast cell from birth to division
Edda Klipp – Humboldt Universität zu Berlin, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
16:45 – 17:00Multi-omics reveals clinically relevant proliferative drive associated with mTOR-MYC-OXPHOS activity in chronic lymphocytic leukemia
Junyan Lu – EMBL Heidelberg, Germany
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:00 – 17:25Combining genetics and proteomics data for integrative structure determination
Ignacia Echeverria Riesco – University of California, San Francisco, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
17:25 – 17:35Break
17:35 – 18:00Systematic investigation of gene function in gut bacteria using randomly barcoded transposon insertion libraries
KC Huang – Stanford University, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
18:00 – 18:15Extracting Mechanistic Insight into SARS-CoV-2 and Emerging Variants by Integrating Orthogonal Molecular Datasets
Mehdi Bouhaddou – QCRG, University of California, San Francisco, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
18:15 – 18:40Chimeric genes, neogenes and hybrid regulatory elements control infection and cell specification
Ivan Marazzi – Icahn School of Medicine at Mount Sinai, USA
AVAILABLE ON DEMAND AFTER LIVE STREAM
18:40 – 19:10Break
19:10 – 20:10Virtual Poster Session 3 (All)
20:10 – 20:55Panel Discussion Day 3 Speakers
Chairs: Thomas Höfer and Uwe Sauer

Panelists:
Ignacia Echeverria Riesco – University of California, San Francisco, USA
KC Huang – Stanford University, USA
Edda Klipp – Humboldt Universität zu Berlin, Germany
Ivan Marazzi – Icahn School of Medicine at Mount Sinai, USA
Kyung-Min Noh – EMBL Heidelberg, Germany
Evangelia Petsalaki – EMBL-EBI Hinxton, UK
Bas Teusink – Vrije Universiteit Amsterdam, The Netherlands
20:55 – 21:00Transition to Meet the Speakers Day 3
21:00 – 21:30Meet the Speakers Day 3
Ignacia Echeverria Riesco, KC Huang, Edda Klipp, Ivan Marazzi,
Kyung-Min Noh, Evangelia Petsalaki, Bas Teusink and short talk speakers Patrick Forny, Junyan Lu, Mehdi Bouhaddou
21:30 – 21:35Transition over to Closing Remarks
21:35 – 21:45Closing remarks and Poster Prizes

Digital posters and pre-recorded talks as well as discussion channels will be available for registered participants throughout the whole virtual meeting.

Practical Information

Registration Fees and Abstract Submission

Registration Fees (include access to all of the talks, digital poster sessions and online group discussions, and help us cover our costs to run the event. For further information please refer to the FAQ page):

Academia190 Euro
PhD Student140 Euro
Industry240 Euro
EMBL StaffIntranet access

Accredited journalists may be eligible to register for a complimentary registration. Registrants may be required to provide accreditation or equivalent proof of press membership after registration. Please contact Maria Bacadare for more information.

Confirmation and Payment

Registration will be on a first-come first-served basis. Your place can only be confirmed after payment of the registration fee.
Types of payments accepted are international bank transfers and credit card payments.

Abstract submission

Abstract submission for this conference is closed. For enquiries about submitting a late abstract for a poster presentation, please contact Nathalie Sneider.

Financial Assistance

Registration Fee Waivers

All academic and student registrants are invited to apply for a registration fee waiver, provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO. The registration fee waiver covers the registration sum that you have paid to attend the meeting. Conference participants are not required to pre-pay the registration fee to be selected for a fee waiver for a virtual meeting. If you have already paid the registration fee and are awarded a fee waiver, it will be reimbursed after the meeting. Course participants are required to pay the course fee in advance, which will then be reimbursed after the recipient has attended the course.

Childcare Grants

For participants and speakers with childcare responsibilities there is the possibility to apply for a grant, provided by the EMBL Advanced Training Centre Corporate Partnership Programme and EMBO, to offset childcare costs incurred when participating at a virtual event. Eligible costs include fees for a babysitter or childcare facility or travel costs for a care giver. Please note that priority will be given to early stage researchers. Costs will be reimbursed after the meeting only once a reimbursement form and original receipts have been received. Attendance at the event is required in order to be eligible to receive the reimbursement. In order to apply for this grant, you must be registered by the abstract submission deadline.

Application

Applications for financial assistance can be submitted via the submission portal* (for the submission of abstracts for conferences or the submission of motivation letters for courses) by completing the Financial Assistance Application Section (underneath the section for entering abstract/motivation letter information). The link to the portal can be found in the registration confirmation email that you will receive after registering for the conference or course.

For conferences, if you are not submitting an abstract, you can still apply for financial assistance in the submission portal by following the instructions here. Note that priority will be given to those submitting an abstract to present at the conference. In your application you will be asked to answer questions regarding your motivation for applying, and, for registration fee waivers, the reasons why your lab cannot fund your attendance and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

*For some events, applications for Childcare Grants will still be done by email. Information about the grant will be sent out shortly after the abstract/motivation letter deadline. Please contact the event Conference Officer if you have any questions.

Selection

The scientific organisers will select the recipients of registration fee waivers during the abstract selection process for conferences and the participant selection process for courses. Results will be announced approximately 3 – 4 weeks before the event start date. Selection results do not impact your admission to the meeting. Registration fee waiver selection is based on your current work or study location, your motivation for applying, the reasons for needing financial support and the impact this event will have on your career. Childcare grants are allocated based on career stage, with priority given to early stage researchers.

Further details

A list of external funding opportunities can be found here, and information on attending a conference as an event reporter here.

For further information about financial assistance please refer to the FAQ page.

Virtual Participation Guidelines

Guidelines

Please do:

  • Use the event-specific hashtag as communicated during the event for any related tweets
  • Tweet unless the speaker specifically says otherwise
  • Be mindful of unpublished data
  • Be respectful in tone and content

Please don’t:

  • Share your login details to the virtual conference platform with others
  • Broadcast the conference to unregistered participants
  • Capture, transmit or redistribute data presented at the meeting unless presenter gives explicit consent
  • Use offensive language in your posts
  • Engage in rudeness or personal attacks

Additional information can be found in our Code of Conduct.

Health and well-being

It is important to stay healthy and move around, especially when you are attending an event virtually. We have put together a few coffee break stretches and yoga videos in the virtual conference platform for you to enjoy during the event.

How to ask questions

Please use the Q&A function. It is possible to send a direct message to participants, poster presenters, and speakers within the conference platform.

If you have any other questions, you can go to the Help Desk on the conference platform. Click on ‘more’ on the top menu and click Help Desk. 

Time zone

The programme is planned based on the Europe/Berlin time zone, unless otherwise stated. As many virtual participants are attending from around the world, we do our best to accommodate as many time zones as possible when creating the programme. Please take your time zone into consideration when planning your attendance.

Virtual event platforms

We are using a virtual event platform for this conference. More information about the platform will be shared ahead of the conference.

Sponsors

Media Partners

Molecular Systems Biology, an EMBO Press journal

International Union of Biochemistry and Molecular Biology

Open Biology, a Royal Society journal

Sponsorship Opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Warning

EMBL wishes to warn sponsors of EMBL conferences and courses of fraudulent schemes purporting to offer sponsorship opportunities on behalf of EMBL or affiliated with EMBL officials. One current scam campaign of which we are aware is conducted using the name ‘Judy Eastman’ (judy@gopcontact.a2hosted.com) and entails approaches to sponsors offering sponsorship opportunities on EMBL’s behalf. Please be kindly advised that all relevant communication regarding sponsorship of EMBL conferences, symposia and courses is handled by EMBL directly and is sent from an official EMBL account. EMBL does not work with any external providers on sponsorship acquisition.

Please also note that:

  • EMBL never provides attendee lists for purchase. Any offers of such are fraudulent.
  • EMBL will never call or email you to ask for your credit card details or to request a payment.
  • All payments are on invoice.

Suspicious communications purportedly from, for or on behalf of EMBL should be reported to EMBL at the following email address sponsoring@embl.de.

About

EMBO | EMBL Symposia promote scientific communication and collaboration in the European research area. They provide scientists with a platform to discuss and exchange ideas on forward-looking topics and new developments in the life sciences.

Topics emphasise upcoming developments and the interdisciplinary nature of related fields. Jointly funded and organised by EMBO and EMBL – and complementary to their respective courses, workshops, and conference programmes – the symposia promote scientific communication and collaboration.

All symposia are held in the EMBL Advanced Training Centre (ATC) in Heidelberg, Germany, or virtually.

Date: 15 - 17 Sep 2021

Location: Virtual


Deadline(s):

Abstract submission: Closed

Registration: Closed


Organisers:

  • Nevan Krogan
    University of California, San Francisco, USA

EMBL Courses and Conferences are kindly supported by our Corporate Partnership Programme

Founder partners

Corporate partners

Associate partners

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