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Humanized Mice, Personalized Therapies and Big Data – Course and Conference Office

EMBO Practical Course

Humanized Mice, Personalized Therapies and Big Data

Overview

Registration is not yet open for this event. If you are interested in receiving more information please register your interest.

Course Overview

Humanized mouse engraftment models (human immune system and/or human tissue) are an integral part of basic and translational research for the understanding of human diseases and for development of new therapies. The Ebola Virus outbreak has demonstrated the relevance of humanized mouse models for the understanding of emerging diseases and testing new medicines. The same can apply for the Coronavirus (COVID-19) pandemic. “Big pharma” and biotech companies include humanized mice in their pre-clinical development portfolio to test efficacy and safety of anti-cancer drugs. These platforms provide researchers and drug developers with human specific targets, physiological pathways and mechanisms of disease not found in traditional mouse models of disease. These aspects of the humanized models allow direct testing of human versus mouse specific therapies enabling more rapid drug development and the generation of more clinically relevant data. During the last decade these models have substantially diverged among laboratories regarding the mouse strains used, mouse handling, analyses techniques and sources of human material. This experimental variability is expected as the field is dynamic and growing rapidly, but the data documentation and reporting should be better standardized for metadata analyses.

This course will teach the participants the principles of experimental pre-requisites and harmonized analyses (e.g., flow cytometry, RNA sec and genomic analyses).

Audience

This course is aimed at principle investigators, postdocs, clinicians, and PhD students who have already experience with humanized mouse models and would like to refine their analysis methods as well as get an overview of available models that might fit best to their research question.

Modules

  • Conceptual introductory keynote lecture
  • Human immune reconstitution                              
  • Human immuno-oncology                                       
  • Human oncology and genomics                             
  • Human infections and transcriptomics                                
  • Human tissue regeneration                                     
  • Ethics for human material and animal experimentation                
  • Data management and analysis                                                    

Learning Outcomes

Conceptual and practical aspects for generation and uses of humanized models:

  • Single cell preparation and analyzes from humanized mice
  • Multicolor flow cytometry from human-mouse chimeras
  • RNA/protein/gene analyzes from tissue of (infected) humanized mice
  • Microscopy to define immune invasion and pathological changes during infection, tumor development, and therapy
  • Practical class for (neonatal) transplantation, implantation, and sample collection

Speakers and Trainers

Speakers

Simon Haas

Berlin Institute of Health at Charité

Germany

Angela Wahl

The University of North Carolina at Chapel Hill

USA

Trainers

Simon Haas

Berlin Institute of Health at Charité Universitätsmedizin

Germany

Scientific Organisers

Course Organisers

Raili Pall

Course and Conference Officer

EMBL Heidelberg

Germany

Irena Provaznikova

Training Lab Technician

EMBL Heidelberg

Germany

Sponsors

Sponsorship Opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Date: 12 - 17 Jun 2022

Location: EMBL Heidelberg

Organisers:

  • Karl-Dimiter Bissig
    Duke University Medical Center, USA
    • Christian Münz
      University of Zurich, Switzerland
      • Isabel Rollan
        EMBL Heidelberg, Germany
        • J.J. Schuringa
          University of Groningen, The Netherlands
          • Leonard Shultz
            The Jackson Laboratory, USA
            • Brian Soper
              The Jackson Laboratory, USA

EMBL Courses and Conferences are kindly supported by our Corporate Partnership Programme

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