Integrative structural biology: solving molecular puzzles – Course and Conference Office

EMBO Practical Course

Integrative structural biology: solving molecular puzzles


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Course overview

Integrative structural biology has become a key strategy for determining the structure of biological macromolecules and their complexes. This method entails characterising the 3D structure through an array of complementary techniques, subsequently combining the data to form a consensus model using computational methodologies.

This practical course offers a hands-on introduction to integrative structural biology. Participants will delve into the fundamentals of various experimental structure determination techniques including X-ray crystallography, cryo-EM, small-angle X-ray scattering, NMR, and mass spectrometry, through both lectures and practical exercises. Experts in the field will guide participants on how to analyse and interpret experimental data, and construct structural models across different resolution scales. A significant aspect of the course includes exploring how integrative structural biology addresses limitations of Artificial Intelligence-based structure prediction methods in modelling large complexes and their functional conformations. It will also highlight the emerging field of integrative structural biology of biomolecular complexes visualised directly in their cellular context.

The course location at the European Molecular Biology Laboratory in Hamburg and the Center for Structural Systems Biology on the DESY campus will provide on-site synchrotron SAXS and MX beamlines for training. A guided visit to the European XFEL site is also included in the programme.


Sponsorship opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other events, or contact sponsorship@embl.de for further information.

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Date: 17 - 24 Nov 2024

Location: EMBL Hamburg

Venue: Centre for Structural Systems Biology (CSSB)


  • Arjen Jakobi
    Kavli Institute of Nanoscience, TU Delft, The Netherlands
    • Jan Kosinski
      EMBL Hamburg, Germany
      • Maya Topf
        Leibniz Institute of Virology, University Medical Center Hamburg-Eppendorf, and Centre for Structural Systems Biology (CSSB), Germany

      Contact: Luana Ribeiro

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