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Methods for analysis of circRNAs: from discovery to function – Course and Conference Office

EMBO Practical Course

Methods for analysis of circRNAs: from discovery to function

Overview

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Course Overview

Circular RNAs (CircRNAs) are a rediscovered class of RNA species that originate from back-splicing events, which have been reported across all domains of life. Many circular RNAs are stable, abundant and conserved between species. They exhibit context-dependent expression patterns, which are often linked to disease states. Validated circular RNA functions are numerous and range from regulation of transcription and splicing to RNA/protein sponging and scaffolding. However, CircRNAs are by and large the most underexplored class of all non-coding RNAs. This course will meet the specific need to explore complexity, distribution, function and mechanisms of circRNA action experimentally and computationally.
The presented methods and approaches are widely applicable to all organisms beyond standard models. Lectures will cover the technological background of circular RNA research and present the latest advancements from biology, chemistry and medicine. The practical part will include detection and quantification of circRNAs by low- and high-throughput methods, data analysis and integration as well as comprehensive computational assessment of circRNA candidates, function prediction and experimental design of follow-up experiments.

Audience

This course is intended for PhD students and young Postdoctoral researchers.

Modules/Resources

  • RNA splicing
  • Computational biology
  • Gene expression
  • RNA localisation
  • Quantitative biology

Learning Outcomes

Participants will go through all wet-lab steps required for preparation of circRNA-seq libraries and will be introduced to basic bioinformatics required for analyses of circRNA-seq data.

Sponsors

Sponsorship Opportunities

We offer a variety of event sponsoring possibilities, with the flexibility to select a set sponsorship package or combine individual sponsorship options to suit your event budget. Discounts are available for companies sponsoring multiple events at EMBL Heidelberg. View other conferences, or contact sponsorship@embl.de for further information.

If you are interested in becoming a media partner of this event, please visit our media partnerships webpage.

Date: 23 - 29 Apr 2022

Location: EMBL Heidelberg

Organisers:

  • Marie-Laure Baudet
    University of Trento, Italy

EMBL Courses and Conferences are kindly supported by our Corporate Partnership Programme

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