Time-resolved macromolecular serial crystallography

Time (Europe/Berlin)	Speaker
08:00 – 09:20	Registration / Welcome coffee
09:20 – 09:30	Official Welcome Overview of the course
09:30 – 10:30	Serial crystallography – brief history and scientific significance Henry Chapman – DESY, Germany
10:30 – 11:00	Coffee break
11:00 – 12:30	Participant flash talks
12:30 – 13:30	Lunch
13:30 – 14:30	Introduction to beamlines for time-resolved serial crystallography Daniele de Sanctis – ESRF, France
14:30 – 15:00	Detectors for time-resolved serial crystallography Sofia Trampari – Dectris, Switzerland
15:00 – 15:30	Coffee break
15:30 – 16:30	Signal to noise and other challenges in time-resolved serial crystallography James Holton – Lawrence Berkeley National Laboratory / University of California San Francisco, USA
16:30 – 17:30	Radiation damage in serial crystallography Elspeth Garman – University of Oxford, United Kingdom
17:30 – 18:30	Responsible conduct of research session Discussion round FAIR use of data & how this is practically done for serial crystallographic data Experimental design and development of community standards for serial data quality Sustainability in experimental design and data archiving
18:30 – 19:30	Dinner
19:30 – 20:30	Poster session

Time (Europe/Berlin)	Speaker
08:55 – 09:00	Overview of the day
09:00 – 10:00	Crystal quality/homogeneity/density – what is a good sample? Ashwin Chari – Max Planck Institute for Multidisciplinary Sciences, Germany
10:00 – 10:30	How to grow microcrystals John Beale – Paul Scherrer Institute / SwissFEL, Switzerland
10:30 – 11:00	In cell crystallization for serial crystallography Lars Redecke – University of Lübeck, Germany
11:00 – 11:30	Coffee break
11:30 – 12:00	Protein-nucleic acid complexes Claude Sauter – CNRS-IBMC, France
12:00 – 12:30	Time-resolved crystallography using Hadamard encoding (HATRX) Briony Yorke – University of Leeds, United Kingdom
12:30 – 13:00	Serial electron diffraction Robert Bücker – Rigaku Europe, Germany
13:00 – 14:00	Lunch
14:00 – 16:00	Practicals A-D in parallel (one group of 5 participants per practical; 1 h per practical) Practical A: “Fixed target loading and time-resolved data collection using LAMA at T-REXX” Lead trainer: David von Stetten Practical B: “TapeDrive and time-resolved data collection at P11” Lead trainer: Johanna Hakanpää Practical C: “SpitRobot (HARBOR)” Lead trainer: Pedram Mehrabi Practical D: “Batch micro- and nano-crystallization (HARBOR)” Lead trainer: Dominik Oberthür
16:00 – 16:30	Coffee break
16:30 – 18:30	Practicals A-D in parallel (one group of 5 participants per practical; 1 h per practical) Practical A: “Fixed target loading and time-resolved data collection using LAMA at T-REXX” Lead trainer: David von Stetten Practical B: “TapeDrive and time-resolved data collection at P11” Lead trainer: Johanna Hakanpää Practical C: “SpitRobot (HARBOR)” Lead trainer: Pedram Mehrabi Practical D: “Batch micro- and nano-crystallization (HARBOR)” Lead trainer: Dominik Oberthür
18:30 – 19:30	Free time and travel to course dinner
19:30 – 22:30	Course dinner at Fischclub Blankenese

Time (Europe/Berlin)	Speakers
08:55 – 09:00	Overview of the day
09:00 – 10:00	Best practice for time-resolved experiments Arwen Pearson – University of Hamburg, Germany
10:00 – 11:00	Mixing and microfluidics for serial crystallography Alexandra Ros – Arizona State, USA
11:00 – 11:30	Coffee break
11:30 – 12:00	Fixed-target sample delivery & liquid droplets for reaction initiation (LAMA) Pedram Mehrabi – University of Hamburg, Germany
12:00 – 12:30	Photochemistry for time-resolved crystallography Gülbahar Bozan – University of Groningen, The Netherlands
12:30 – 13:00	2D crystals and dynamic retrieval Cecilia Casadei – MAX IV, Sweden
13:00 – 14:00	Transfer to European XFEL & buffet lunch in XFEL foyer
14:00 – 15:30	Robin Schubert: Tours and Live Demos at European XFEL
15:30 – 16:30	Transfer back to SCHB & tea break
16:30 – 18:30	Practicals E and F in parallel (one group of 10 participants per practical; 1 h per practical) Practical E: Serial electron diffraction Lead trainer: Carolin Seuring + 1 tutor Practical F: “Crystal Controller: tracking the early stages of crystallization” Lead trainers: Robin Schubert & Claude Sauter
18:30	Free evening

Time (Europe/Berlin)	Speaker
08:55 – 09:00	Overview of the day
09:00 – 10:00	Best practice for time-resolved experiments Arwen Pearson – University of Hamburg, Germany
10:00 – 11:00	Mixing and microfluidics for serial crystallography Alexandra Ros – Arizona State, USA
11:00 – 11:30	Coffee break
11:30 – 12:00	Fixed-target sample delivery & liquid droplets for reaction initiation (LAMA) Pedram Mehrabi – University of Hamburg, Germany
12:00 – 12:30	Photochemistry for time-resolved crystallography Gülbahar Bozan – University of Groningen, The Netherlands
12:30 – 13:00	2D crystals and dynamic retrieval Cecilia Casadei – MAX IV, Sweden
13:00 – 14:00	Transfer to European XFEL & buffet lunch in XFEL foyer
14:00 – 15:30	Robin Schubert: Tours and Live Demos at European XFEL
15:30 – 16:30	Transfer back to SCHB & tea break
16:30 – 18:30	Practicals E and F in parallel (one group of 10 participants per practical; 1 h per practical) Practical E: Serial electron diffraction Lead trainer: Carolin Seuring + 1 tutor Practical F: “Crystal Controller: tracking the early stages of crystallization” Lead trainers: Robin Schubert & Claude Sauter
18:30	Free evening

Time (Europe/Berlin)	Speaker
08:55 – 09:00	Overview of the day
09:00 – 11:30	Brainstorming session Participant Groups will work together to draft a beamtime proposal for a time-resolved serial crystallographic experiment on one of their own scientific projects at either a synchrotron or XFEL
11:30 – 12:00	Coffee break
12:00 – 12:15	Presentation Group 1 and Feedback
12:15 – 12:30	Presentation Group 2 and Feedback
12:30 – 12:45	Presentation Group 3 and Feedback
12:45 – 13:00	Presentation Group 4 and Feedback
13:00 – 14:00	Course evaluation and closing remarks
14:00 – 14:30	Packed lunch and departure

The course is limited to 20 participants. For selection purposes, please note that your application will not be considered without a letter of motivation.

Registration fees

Your registration for the event includes:

• Admission to the event
• Meals and coffee breaks
• Course materials
• Access to the e-learning platform
• A letter to support your visa application (for more information, check the ‘Travel and accommodation’ tab)

• For this EMBO course, the fees include accommodation

Academia	€500
PhD Student	€500
Industry	€1100

Confirmation and payment

The registration fee should be paid only after acceptance to the course. The results will be announced approximately 2-3 weeks after the application deadline.

Cancellation policy

If you are no longer able to take part in the course, please inform your course contact responsible for this event. Your registration and the submitted motivation letter will be deleted.

Please also check our Terms and Conditions for the cancellation policy.

After you have logged in and successfully registered, you will receive an email asking you to submit your motivation letter. Click on the link provided and enter your motivation letter in the text box provided. Alternatively, you can submit your motivation letter by clicking on the link on the confirmation page directly after registering.

Instructions

1. Include your relevant skills, experience and qualifications showing why you would be suitable for the course.
2. Explain why you would like to attend, including what you can contribute and how you think you will benefit from the course.

Please note:

• The limit of 2,000 characters refers to manually typed text and excludes spaces. If an error occurs, try using a different web browser (preferably Google Chrome or Mozilla Firefox).
• If you copy-paste the text into the form, hidden formatting might still be included which may cause the text to exceed the 2,000 character limit resulting in an error message. We recommend you clear all formatting before pasting in the text.
• If you have special symbols in your text, make sure you are using Unicode characters, otherwise these will not be recognised.

For detailed instructions, please watch our video on how to submit a course motivation letter.

Further details

For further information about registration and motivation letter submission please refer to the FAQ page.

Financial assistance

Limited financial assistance is provided by EMBO in the form of travel grants and childcare grants. 

Your place in the meeting is only confirmed by paying the registration fee, which is mandatory even when receiving a fee waiver.

Travel grant

The travel grant will cover the cost of travel (airfare, train, bus, taxi, and visa) and/or registration fees and is provided up to specified caps which are normally as follows:

– up to €500 for any participant travelling to an EMBO Practical Course.

– up to €1000 for any participant working in Chile, India, Singapore or Taiwan travelling to an EMBO Practical Course.

The organisers may reduce the grant cap to accommodate more participants. Recipients will be notified of their travel cap amount when they are informed of the outcome of their application. Original receipts must be provided with your signature for all costs incurred within two months of completion of travel.

Childcare grants

There is the possibility to apply for a childcare grant to offset child care costs incurred by participants, speakers, trainers and organisers when attending a course. Eligible costs include (but are not limited to) fees for a babysitter or child-care facility and travel costs for a caregiver. Please note that priority will be given to early-stage researchers. There is a limited amount of funding available for the childcare grants and funds will be distributed amongst eligible applicants.

Boehringer Ingelheim Fonds travel grant

Applies to selected courses only. Availability will be indicated during the abstract or motivation letter submission process.

This grant covers costs related to your attendance to the course (registration, travel and accommodation costs). The grant is restricted to PhD students and postdocs who conduct basic biomedical research.
Whether you are eligible to apply for a travel grant, depends on when you received your university entrance qualification (e.g. Abitur, A-Levels, High School Diploma, Final State Examination):

– for PhD and MD students, as well as graduates, the university entrance qualification must not have been obtained more than 11 years ago at the time of the envisaged course
– for postdocs, the university entrance qualification must not have been obtained more than 13 years ago at the time of the envisaged course

EMBO Accessibility Grant

For EMBO Practical Course participants with accessibility needs, there is the possibility to apply for an accessibility grant to offset costs incurred by participants or speakers when participating at a course. Eligible costs include costs incurred for equipment or adaptations to the course environment, or travel costs for an event companion to assist the participant or speaker during the course where necessary, etc. While we do our best to accommodate needs, please note that extensive changes to the conference environment might not be possible.

Please note that priority will be given to early-stage researchers. A maximum amount of €500 can be awarded per participant applying for an EMBO accessibility grant. In order to apply for this grant for EMBO Courses, you must be registered by the application deadline. 

Application

If you are attending virtually, you can apply for financial assistance in the submission portal by the abstract deadline. Read the instructions on how to apply for financial assistance. Only submissions for financial assistance will be accepted. Presentation abstracts cannot be submitted here and will be declined. 

In your application you will be asked to summarise your current work,  answer questions regarding why your lab cannot fund your attendance, and how your attendance will make a difference to your career. Application for financial support will not affect the outcome of your registration application.

Selection

A selection process will take place with the results announced by email to all applicants / submitters. We aim to announce 3 weeks (21 days) after the abstract submission deadline but delays may occur.”

Selection results do not impact your admission to the meeting. Selection for registration fee waivers and travel grants is based on scientific merit, your current work or study location, the reasons for needing financial support, and the impact this event will have on your career.

Childcare grants will be allocated in the same timeframe (6-8 weeks before the event start date). Please note that priority will be given to early-stage researchers.

Further details

Check out this list of external funding opportunities. 

For further information about financial assistance please refer to the FAQ page.

Visa

We can send you a registration confirmation to support your visa procedure (not an official invitation letter). Please contact the Conference Officer responsible for your event. Read our FAQ for more information.

Accommodation and travel

Reservations for single room accommodation at the DESY hostel have been made. Note, accommodation is included in the registration fee. The guest house is within a few minutes’ walk from the EMBL laboratories and P12 beamline.

Further information

Address: EMBL Hamburg, Notkestraße 85, Building 48e, 22607 Hamburg, Germany

From Hamburg airport take line S1 to Othmarschen (18 stops, 45 min), change to bus number 1 towards Rissen or Schenefelder Holt to Zum Hünengrab (DESY) (5 stops, 10 min).

From Hamburg-Altona train station take bus number 1 to Zum Hünengrab (DESY) (15 stops, 25 min). Ticket costs Public Transport: ca. €3.60 and a taxi will be around €45.

The EMBL eCampus learning platform will be used to collaborate, communicate and network with all of the course participants. All participants will receive information on how to join shortly before the course. We recommend using Chrome, Safari or Mozilla Firefox browsers for eCampus. 

Other information

While using the software during the course, please make sure you have nothing else using your bandwidth.

Please find additional information including FAQs and terms and conditions on our Information for Participants page.