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genomics

Year
1 August 2024 Open Targets logo

Why clinical trials stop: the role of genetics

Science & Technology Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.

2024

research-highlightsscience-technology

25 July 2024

DECIPHER v11.27 release

The v11.27 DECIPHER release is out now. Find out about the new features and improvements.

2024

updates-from-data-resources

21 June 2024

Welcome: Mallory Freeberg

People & Perspectives The new Team Leader for Human Genomics at EMBL-EBI shares how curiosity and maths shaped her career and what it takes to be a community builder.

2024

people-perspectivesperspectives

28 May 2024 An illustration of cells in a mosaic context, demonstrating the idea of genetic mosaicism in blood stem cells.

Genetic mosaicism more common than thought

Science & Technology Blood stem cells from healthy people carry major chromosomal alterations, a study in Nature Genetics by researchers at the Max Delbrück Center and the European Molecular Biology Laboratory (EMBL) finds. The discovery suggests that we are all genetic mosaics, which may contribute to ageing-related…

2024

science-technology

28 May 2024 DECIPHER logo

DECIPHER v11.26 release

The latest DECIPHER release includes AlphaMissense scores, links to the Open Targets Platform and more.

2024

updates-from-data-resources

13 May 2024 Ensembl logo in white circle on blue and green background

Ensembl 112 has been released

Ensembl 112 and the corresponding release of Ensembl Genomes 59 has released. This includes exciting new fish species, many more drosophila species and new VEP updates.

2024

updates-from-data-resources

30 April 2024 Open Targets logo

MSD joins the Open Targets consortium

EMBL Announcements MSD joins as the latest partner in the Open Targets consortium, enhancing the initiative’s collaborative efforts in drug discovery.

2024

announcementsembl-announcements

27 March 2024

Using Data Hubs to analyse SARS-CoV-2 and other pathogen sequences

The SARS-CoV-2 Data Hubs are a set of tools coupled with infrastructure that support four components: the submission, analysis, presentation and visualisation of SARS-CoV-2 raw read data, and its resulting analyses. What makes Data Hubs attractive is a unique set of features: A new publication in…

2024

updates-from-data-resources

28 February 2024 DECIPHER logo

DECIPHER v11.24 Released

Version 11.24 of DECIPHER introduces a new ACMG/AMP pathogenicity interface for sequence variant predictions, displays ClinGen Variant Curation Expert Panel recommendations on gene pages, and updates ACMG secondary finding information to v3.2.

2024

updates-from-data-resources

12 January 2024 Ensembl logo in white circle on blue and green background

Ensembl 111 has been released

The Ensembl 111 features a range of new Ensembl VEP plugins and updated agricultural, fish, plant and metazoa species.

2024

updates-from-data-resources

15 November 2023 Two male scientists in lab coats looking at.a computer screen

Embracing the genome sequencing revolution

EMBLetc EMBL’s Genomics Core Facility provides end-to-end support to researchers across Europe and beyond and stands at the forefront of scientific breakthroughs.

2023

21 September 2023

Understanding the mechanisms of enzyme catalysis

Science & Technology Enzymes constitute a large fraction of genomes – 20% in humans – which makes them a very important part of life. Despite decades of studies and a rich literature dedicated to understanding the reaction mechanisms of enzymes, the rules of enzyme catalysis are still not fully clear. A new…

2023

science-technologytechnology-and-innovation

21 September 2023 Man standing outside

Welcome: David Hulcoop

Lab MattersPeople & Perspectives David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets.

2023

announcementslab-matterspeople-perspectives

17 July 2023 Ensembl logo in white circle on blue and green background

Ensembl 110 has been released

Ensembl 100 release brings exciting updates, such as the addition of regulation data to 5 animal genomes studied extensively in agriculture.

2023

updates-from-data-resources

16 May 2023

Managing a bioinformatics core facility

BioImage Archive Team Leader Matthew Hartley shares his experience and tips for people interested in managing a bioinformatics core facility.

2023

technology-and-innovation

10 May 2023 Globe with genome data from multiple people

A more diverse human reference genome

Science & Technology The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.

2023

announcementssciencescience-technology

18 April 2023 Decorative image showing WormBase ParaSite logo

WormBase ParaSite 18 released

Science & Technology WormBase ParaSite release 18 adds largest number of new genomes and annotations since launch, as well as full integration with AlphaFold.

2023

science-technologyupdates-from-data-resources

11 April 2023 Phylogenetic tree with beams of light to represent data

MAPLE: a phylogenetic tool for pandemic-scale genome data

Science & Technology EMBL-EBI researchers have developed a new tool capable of performing state-of-the-art phylogenetic inference on larger datasets than previously thought possible.

2023

research-highlightssciencescience-technology

22 March 2023 Artistic representation that features a long, winding helix joining together a doughnut-figure to a small shaggy ball to indicate the connections long-read sequencing can make about DNA mutations.

The ‘long read’ for cancer

Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.

2023

science

23 February 2023 Decorative image

New Job Dispatcher website launched

EMBL-EBI’s Software Development and Operations team is delighted to announce the launch of a brand-new Job Dispatcher website, currently in development.  The updated website provides a landing page for the Job Dispatcher services, making it easier for users to find and navigate services…

2023

updates-from-data-resources

13 February 2023 Female scientist stands in front of lab bench

Welcome: Hanh Vu

Lab MattersPeople & Perspectives Group Leader Hanh Vu studies ‘immortal’ flatworms that can grow and de-grow to understand better factors that determine organisms’ sizes.

2023

lab-matterspeople-perspectives

8 February 2023 Ensembl logo in white circle on blue and green background

Ensembl 109 has been released

Latest Ensembl and Ensembl Genomes releases bring updates to donkey and horse assemblies, and lots of new plants and metazoa.

2023

updates-from-data-resources

11 November 2022 Photos of four panel discussion speakers

Open science for climate justice

Our experts discuss the importance of open science for food security and preserving global biodiversity.

2022

perspectivesscience

21 October 2022 Ensembl logo in white circle on blue and green background

Ensembl 108 has been released

We are pleased to announce the release of Ensembl 108, and the corresponding release of Ensembl Genomes 55 featuring changes in the human default tracks, new genomes in Ensembl Plants and Ensembl Metazoa, and the addition of mitochondrial annotation for Tasmanian devil. Genome assemblies and…

2022

updates-from-data-resources

20 September 2022 8 representatives of both the Dieter Schwarz Foundation and EMBL are standing in the EMBL Imaging Centre foyer facing the camera

Life Science Alliance starts new chapter

ConnectionsLab Matters Dieter Schwarz Foundation renews 3-year funding to EMBL for the EMBL | Stanford Life Science Alliance, a unique international collaboration bringing together researchers from the two leading institutions to develop transformative technologies and accelerate biomedical research.

2022

connectionslab-matters

13 July 2022 Decorative image showing a double helix DNA road and with what look like road signs.

Uncharted territories in the human genome

Science & Technology Scientists identify previously unexplored gene segments to be added to human genome databases.

2022

research-highlightssciencescience-technology

12 July 2022 Ensembl logo in white circle on blue and green background

Ensembl 107 has been released

The Ensembl 107 release contains updates to regulatory annotations and updated vertebrate and metazoan species.

2022

updates-from-data-resources

7 July 2022 Single Cell Expression Atlas logo on green background

Interactive data visualisation for Single Cell Expression Atlas

Using powerful data visualisation and interactive search results across datasets allows users to explore hypotheses across a range of metadata, and discover new insights backed by expertly curated, consistently reanalysed single cell sequencing data. Searching for metadata, allows a powerful…

2022

updates-from-data-resources

11 May 2022 Man standing on a balcony

Peter Harrison – Genome Analysis Team Leader

Lab MattersPeople & Perspectives Peter Harrison discusses the importance of data accessibility and his passion for biodiversity and agricultural genomics.

2022

lab-matterspeople-perspectives

30 March 2022 Man standing in front of a wall with scientific imagery including protein structures

Welcome: John Lees

Lab MattersPeople & Perspectives John Lees joins EMBL-EBI as a Group Leader in Pathogen informatics and modelling.

2022

lab-matterspeople-perspectives

10 February 2022 Pfizer logo with pipette tips in the background

Pfizer joins the Open Targets consortium

Connections Open Targets, a consortium focused on drug target identification, prioritisation, and validation, announced today that Pfizer has joined as a partner.

2022

announcementsconnectionsscience

16 November 2021 Collage showing different species that play an essential part in global food security, including cattle, pollinators and plants

Can data help feed a hungry world?

Science & Technology How genomics, open data, and multidisciplinary science can improve food security.

2021

sciencescience-technology

15 September 2021 A dark blue classic star map view is overlaid upon scientific data

Charting a multi-omic universe

Science & Technology A research collaboration used machine learning to map tumour molecular make-up, potentially paving way to more customised cancer treatment.

2021

sciencescience-technology

8 September 2021 Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.

Common medications accumulate in gut bacteria

Science & Technology A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.

2021

sciencescience-technology

5 July 2021

Welcome: Sarah Dyer

Lab MattersPeople & Perspectives EMBL welcomes Sarah Dyer, the new Non-Vertebrate Genomics Team Leader at EMBL-EBI.

2021

lab-matterspeople-perspectives

31 May 2021 Collage showing injection needle, coronavirus and vaccine vials

Genomic surveillance of SARS-CoV-2 in England

Science & Technology The largest in-depth analysis of genomic surveillance data mapping out the dynamics of 62 lineages of the SARS-CoV-2 virus.

2021

sciencescience-technology

7 September 2020 Human silhouette showing internal organs including oesophagus and stomach. Circle with DNA bases A,T, C and G superimposed.

Genome sequencing accelerates cancer detection

Science & Technology The Gerstung Group at EMBL-EBI and collaborators have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing oesophageal cancer.

2020

sciencescience-technology

19 August 2020 A human heart sits at the centre of the illustration. The left ventricle is see-through, showing patterns of trabeculae. Around the heart are some notes from Leonardo da Vinci.

New clues to a 500-year old mystery about the human heart

Science & Technology An international team of scientists involving Ewan Birney's group has investigated the function of a complex mesh of muscle fibres that line the inner surface of the heart.

2020

sciencescience-technology

5 August 2020 The tuatara, an iguana-like reptile with a crest of spikes, sits on a forest floor.

The curious genome of the tuatara, an ancient reptile in peril

Science & Technology A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.

2020

sciencescience-technology

20 July 2020 A magnifying glass hovers over the human gut, revealing its biodiversity.

Unparalleled inventory of the human gut ecosystem

Science & Technology An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health.

2020

sciencescience-technology

8 July 2020 Alexander Aulehla on the left and Paul Flicek on the Right

Two EMBL scientists become EMBO Members

EMBL AnnouncementsLab Matters This year, EMBO elected 63 new members, including Alexander Aulehla, Group Leader and Senior Scientist at EMBL Heidelberg, and Paul Flicek, Associate Director of EMBL-EBI Services, Senior Scientist, Group and Team Leader at EMBL-EBI.

2020

embl-announcementslab-matters

1 July 2020 New Informatics Science Director at Open Targets, Ellie McDonagh

Welcome: Ellie McDonagh

Lab MattersPeople & Perspectives Open Targets welcomes new Informatics Science Director

2020

lab-matterspeople-perspectives

24 June 2020 Artist's impression of DNA lesions. Credit: Petra Korlevic

Unpicking the complexity of DNA mutations

Science & Technology DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.

2020

sciencescience-technology

26 May 2020 Bioinformatic analysis of over 4700 SARS-CoV-2 genomes revealed that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.

Distinguishing coronavirus genome mutations from inadvertent errors

Science & Technology EMBL scientists have performed a large-scale analysis of over 4700 SARS-CoV-2 genome sequences. They found that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.

2020

sciencescience-technology

13 May 2020 Close-up photograph of servers at EMBL Heidelberg's data centre.

Understanding the role of our genes in SARS-CoV-2 infections

Science & Technology EMBL scientists will contribute to the new German COVID-19 OMICS Initiative to study the biological mechanisms contributing to coronavirus infections. EMBL group leaders Jan Korbel and Oliver Stegle, who is also affiliated with the DKFZ Heidelberg, will coordinate the set-up of IT infrastructures…

2020

sciencescience-technology

30 October 2018 Sanofi logo on blue background

Sanofi joins Open Targets

ConnectionsLab Matters Pharmaceutical company Sanofi strengthens drug targets discovery collaboration Open Targets

2018

connectionslab-matters

13 November 2017

Research highlights

Science & Technology A summary of recent research highlights from EMBL

2017

sciencescience-technology

13 March 2017

Futures: Genome regulation

Science & Technology ERC grantee Eileen Furlong shares her vision for the next ten years

2017

sciencescience-technology

13 February 2017

Genetic switches can change shape

Science & Technology EMBL scientists discovered that common mutations can change the shape of gene promoters

2017

sciencescience-technology

4 November 2016 Sequence bundles: screen shot

Collaboration is beautiful

Science & Technology Where design meets bioinformatics, new scientific perspectives abound.

2016

sciencescience-technology

7 July 2016

Mapping early development

Science & Technology “Like getting hold of a microscope for the first time”

2016

sciencescience-technology

30 June 2016

Scientific twins

Science & Technology Collaborations shorten distance between EMBL Heidelberg, Germany, and CEITEC in Brno, Czech Republic

2016

sciencescience-technology

24 March 2016 Zernicka-Goetz lab, University of Cambridge

Foetus, or placenta?

Science & Technology Subtle genetic differences destine cells to placenta or animal, very early in embryo development

2016

sciencescience-technology

3 March 2016 Colorised scanning electron micrograph of red blood cell infected with malaria parasites (blue); uninfected cells with a smooth red surface. IMAGE: (CC BY 2.0)

Mapping malaria

Science & Technology First detailed atlas of start points for genes expression in malaria-causing parasite

2016

sciencescience-technology

2 December 2015 Gut bacteria are more affected by metformin than by the type-2 diabetes it is prescribed to treat. IMAGE: Courtesy of Pacific Northwest National Laboratory (BY-NC-SA)

Drugging bacteria

Science & Technology Commonly used diabetes drug metformin impacts gut bacteria more than disease itself

2015

sciencescience-technology

25 November 2015 IMAGE: EMBL-EBI/Spencer Phillips

What makes us human? Or not…

Science & Technology From jumping genes to organ transplants, the non-human features that make us human.

2015

sciencescience-technology

24 November 2015

Awards & Honours

EMBL AnnouncementsLab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2015

embl-announcementslab-matters

9 November 2015 Bertone and Smith: Unpacking embryonic pluripotency

Unpacking embryonic pluripotency

Science & Technology Embryology, genomics and bioinformatics combine to identify factors regulating mammalian pluripotency.

2015

sciencescience-technology

15 October 2015 MinION™ USB-attached miniature sensing device.

Mini DNA sequencer tests true

Science & Technology Evaluation of MinION™ sequencer finds performance and reliability consistently good.

2015

sciencescience-technology

14 October 2015 single-cell transcriptomics reveals biologically relevant heterogeneity in expression

A snapshot of stem cell expression

Science & Technology Study of mouse embryonic stem cells reveals new genes involved in the stem-cell regulatory network.

2015

sciencescience-technology

2 October 2015 The 1000 Genomes Project: a timeline

A lasting legacy

Science & Technology 1000 Genomes Project pushed technologies and knowledge forward to understand what is 'normal' human genetic variation

2015

sciencescience-technology

1 October 2015 What do diatoms really do? Chris Bowler would like to know. IMAGE: Sebastien Colin

Marine mysteries

Science & Technology From the role of diatoms to how life evolved - scientists' pressing questions about life in the sea.

2015

sciencescience-technology

30 September 2015 The 1000 Genomes Project tracked genetic variation across the globe. EMBL-EBI/Spencer Phillips

Finding links and missing genes

Science & Technology Missing a gene may not be a big deal – a conclusion from global catalogue of genetic changes.

2015

sciencescience-technology

17 September 2015 The scientists combined data from a variety of techniques to better understand how rats – and humans – age. IMAGE: Brandon Toyama/Salk Institute

Ages apart

Science & Technology Multifaceted approach reveals how brain and liver age, helps explain why ageing brain loses plasticity.

2015

sciencescience-technology

24 August 2015

Awards & Honours

EMBL AnnouncementsLab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2015

embl-announcementslab-matters

24 August 2015 Fay Christodoulou, together with EMBL’s Vladimir Benes and Miroculus’ João Pereira de Lima

Decoding disease

Science & Technology Behind the scenes of start-up Miroculus, developing a non-invasive test for early-stage disease.

2015

alumniscience-technology

24 August 2015

An ocean odyssey

Science & Technology A journalist who spent six weeks aboard Tara reflects on the expedition’s extraordinary outcomes.

2015

sciencescience-technology

20 August 2015

The French connection

ConnectionsLab Matters EMBL Core Facilities collaborate with French research programme Signalife to revive training visit.

2015

connectionslab-matters

12 August 2015 Organiser Lars Steinmetz invites young researchers to the conference. PHOTO: EMBL Photolab/Claudiu Grozea

Make it personal

Connections Leading scientists will gather in Heidelberg this November to discuss the potential of personalised health.

2015

connectionsevents

4 August 2015 Healthy bone marrow (left) vs. bone marrow of leukaemia patient (right). IMAGE: MEDIZINISCHEN HOCHSCHULE HANNOVER

From patients to the lab (and back)

Science & Technology Multidisciplinary research provides clues to new treatments for deadly form of leukaemia in children

2015

sciencescience-technology

3 August 2015 To train T-cells to recognise our own body, cells in the thymus express different combinations of 'extra' genes. IMAGE: EMBL/P.RIEDINGER

Know your cells

Science & Technology How T-cells are trained on what not to kill

2015

sciencescience-technology

9 July 2015

DNA protection, inch by inch

Science & Technology European team identify mechanism for producing piRNAs that silence jumping genes in germline cells.

2015

sciencescience-technology

29 April 2015 Riccardo Cortese, former head of the Genome Biology Unit

Inside industry: Part I

Career insights from Riccardo Cortese, whose start-up is developing an Ebola vaccine candidate.

2015

alumni

29 April 2015

Element of surprise

Radiocarbon studies are helping researchers shine light on how neurons stay stable yet adaptable.

2015

science

28 January 2015 Gene expression in 20 mammals

Why is a dolphin not a cat?

How repurposing non-coding elements in the genome gave rise to the great ‘mammalian radiation’.

2015

science

26 January 2015

Awards & Honours

Lab Matters EMBL scientists regularly receive prestigious awards – meet the latest honourees.

2015

lab-matters

16 January 2015

Christian Boulin Fellowship

Lab Matters New Christian Boulin Fellowship: 15 awards of up to €1500 for visitors to EMBL’s Core Facilities.

2015

lab-matters

18 December 2014

Alumni awards

Announcing winners of the John Kendrew Young Scientist Award, and inaugural Lennart Philipson Award.

2014

alumni

15 December 2014

Luxembourg collaboration

Lab Matters Third round of calls for joint research projects between EMBL and Luxembourg in 2015

2014

lab-matters

28 November 2014 WormBase Parasite

Record parasitic worm dataset

Largest collection of helminth genomic data ever assembled, in new open-access WormBase ParaSite.

2014

science

18 November 2014 Kyung-Min Noh. PHOTO: EMBL/M.SCHUPP

Welcome: Kyung-Min Noh

The important thing is forming good biological questions, says new group leader in Genome Biology.

2014

science

17 November 2014 Judith Zaugg. PHOTO: EMBL/M. SCHUPP

Welcome: Judith Zaugg

Whether it’s information or people, the art of connecting is key to new group leader Judith Zaugg

2014

science

14 November 2014 Participants at an EMBL-Illumina training course. PHOTO: EMBL/M. SCHUPP

Next generation training

First series of training courses jointly organised by EMBL and Illumina is a resounding success.

2014

events

10 September 2014 Gibbon genome sequenced

Gibbon genome joins Ensembl

Gibbon genome gives insights into evolution of this singing, swinging, tree-dwelling ape.

2014

science

11 August 2014

From students to mentors

PhD students reap rewards and rave reviews as Summer School of Science organisers

2014

events

8 August 2014

New, improved human genome

Ensembl has incorporated a vast amount of knowledge into a fully annotated reference human genome

2014

science

31 July 2014 Global Alliance for Genomics and Health

New genomics API

Lab Matters New genomics API allows researchers to share anonymised genetic data seamlessly across platforms.

2014

lab-matters

1 July 2014 Vasily Sysoev

Back to school

Lab Matters School ambassadors show next generation that scientists are more ‘role model’ than ‘mad professor’

2014

lab-matters

1 July 2014 Illustration: Aad Goudappel, Rotterdam

Five for the future

Lab Matters Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead

2014

lab-matters

25 June 2014

Taken out of context

Science & Technology Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA

2014

sciencescience-technology

21 June 2014 Ocean Sampling Day 2014

Capturing marine biodiversity

Science & Technology Data from first ever worldwide Ocean Sampling Day will be shared via EMBL-EBI resources this autumn.

2014

sciencescience-technology

24 April 2014

Tsetse fly genome sequenced

Science & Technology Tsetse fly genome sequenced; scientists hope to find new ways to control sleeping sickness.

2014

sciencescience-technology

2 March 2006

A new tree of life allows a closer look at the origin of species

In 1870 the German scientist Ernst Haeckel mapped the evolutionary relationships of plants and animals in the first ‘tree of life’. Since then scientists have continuously redrawn and expanded the tree adding microorganisms and using modern molecular data, yet, many parts of the tree…

2006

science

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