Researchers uncover what drives aggressive bone cancer
Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
Sharing scientific expertise to empower European partners
EMBL and its partners have received funding from the European Commission for two new Twinning Projects, which will build expertise and research capacity in its member states.
CONNECTIONS2024
connections
Fuelling discovery together: 2024 user survey learnings
Blog post by Eleni Tzampatzopoulou, EMBL-EBI Impact Manager In summer 2024, EMBL-EBI ran a user survey, inviting our community to let us know how they use the open data resources we jointly manage with our collaborators. With over 2,300 responses from 126 countries, we were delighted by the depth…
2024
announcements
EMBL Agri-Tech Partnership to deliver safe food and environmental health
The partnership will address global food security challenges through optimised agricultural research and data-driven innovation.
CONNECTIONS2024
connections
Complex Portal expands Human Complexome with ML-predicted human protein complexes
The Complex Portal – an encyclopaedic resource of macromolecular complexes from key model organisms – has expanded its coverage of the Human Complexome. This includes: To find out more, read the new paper entitled Complex Portal 2025: Predicted human complexes and enhanced visualisation tools…
2024
uncategorizedupdates-from-data-resources
Sparking a data revolution
The introduction of computational methods in biology opened up an entirely new world of insights and breakthroughs. Over the last several decades, EMBL has been at the forefront of discoveries and innovations that have not only propelled the field forward but also opened up access to bioinformatics…
SCIENCE & TECHNOLOGY2024
science-technology
Human immune system is ‘ready to go’ long before birth
The most comprehensive map of the developing human thymus sheds light on how immune responses are built and maintained during early life
2024
announcements
We are EMBL: Briony Jackson on community-focused public engagement
Public Engagement Officer Briony Jackson is building lasting relationships with local communities to make science accessible and engaging for all.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
DECIPHER v11.28 Released
The v11.28 DECIPHER release is out now. Find out about the new features and improvements.
2024
updates-from-data-resources
BioChemGraph: Unifying structural and bioactivity data to accelerate drug discovery
In the era of data-driven biology, integrating information from different resources is essential yet often challenging. The BioChemGraph project addresses this challenge by creating infrastructure that consolidates structural, functional, and biochemical annotations for small molecules and their…
2024
updates-from-data-resources
InterPro 102.0 released
InterPro version 102.0 and InterProScan 5.70-102.0 are now available.
2024
updates-from-data-resources
Ensembl 113 and Ensembl Genomes 60 have been released
Ensembl 113 brings major gene and regulatory feature annotation updates in Homo sapiens (human) and Mus musculus (mouse).
2024
updates-from-data-resources
Cancer drug resistance causes and categories identified
Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.
2024
announcements
Computational protein design and protein structure prediction win Nobel Prize in Chemistry
Creators of AI system AlphaFold receive 2024 Nobel Prize for Chemistry.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
Machine learning discoveries honoured with 2024 Nobel Prize for Physics
The prize was awarded to John J. Hopfield, Princeton University, USA, and Geoffrey Hinton, University of Toronto, Canada, for their seminal contributions to the foundational methods that enabled the development of machine learning.
SCIENCE & TECHNOLOGY2024
science-technology
New MGnify Proteins web resources launched
EMBL-EBI’s microbiome data resource MGnify produces a valuable trove of protein sequence data through its ongoing analysis of microbiome derived data. Two new MGnify Proteins web resources make this dataset easily accessible and searchable, both for large queries across the entire database…
2024
updates-from-data-resources
Funding awarded to develop a global Pathogen Data Network
EMBL-EBI and colleagues from other 11 institutes commit to pathogen data sharing project.
2024
announcements
Polygenic Score (PGS) Catalog increases diversity and usability of genetic data
Addition of data from more diverse populations to the Polygenic Score (PGS) Catalog and a new software tool for PGS calculation could help produce more equitable disease risk predictions.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
Single Cell Expression Atlas 21 released
New datasets The release has 381 single-cell RNA-Seq experiments, consisting of more than 13.5 million cells from 21 different species to explore in the Single Cell Expression Atlas (SCEA). The resource now includes an entirely new class of data – externally analysed data, marked with an…
2024
updates-from-data-resources
We are EMBL: Iguaracy Pinheiro-de-Sousa on organoids and nanorobot ‘highways’
EMBL-EBI Postdoctoral researcher Iguaracy Pinheiro de Sousa is using bioinformatics to support the development of better organoids.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
EMBL-EBI’s open data resources for biodiversity and climate research
EMBL-EBI data resources help advance biodiversity and climate change research by enabling scientists to study species interactions, evolutionary processes, ecosystem health, and more.
SCIENCE & TECHNOLOGY2024
science-technologytechnology-and-innovation
AlphaFold database empowers researchers with enhanced structural search via Foldseek integration
Traditional sequence search methods are fast and efficient but rely solely on comparing amino acid sequences. This approach can miss crucial insights because proteins with similar functions can have vastly different sequences. Although their sequences have diverged, these proteins often retain 3D…
2024
updates-from-data-resources
Alvis Brazma: What I’ve learned
EMBL-EBI alumnus Alvis Brazma reflects on how mathematics and mountaineering have shaped his life and why keeping things simple in bioinformatics is key.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Welcome: David Ocaña
EMBL-EBI’s new Head of Applications will use his expertise in cloud infrastructure and security to support the institute’s open data resources.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Why clinical trials stop: the role of genetics
Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
DECIPHER v11.27 release
The v11.27 DECIPHER release is out now. Find out about the new features and improvements.
2024
updates-from-data-resources
We are EMBL: Melanie Schneider on changing career trajectory
ARISE fellow Melanie Schneider shares how she uncovered a new interest in research infrastructures and supporting discovery.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
We are EMBL: Kim Gurwitz on working with global partners to support bioinformatics training
Kim Gurwitz talks about her role as Scientific Training Lead at EMBL-EBI and how collaborative projects for bioinformatics training support researchers and service providers in making the most of publicly available data.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Proteomics: a different lens for precision medicine
The dynamic world of proteomics is shaping the future of personalised medicine, but some obstacles stand in the way
SCIENCE & TECHNOLOGY2024
perspectivesscience-technology
Celebrating 50 years of infinite curiosity
What makes EMBL unique? Among many things, it’s the infinite curiosity of its community.
LAB MATTERS2024
lab-matters
The EMBL evolution: Ewan Birney on open data and the ethos of excellence
Ewan Birney reflects on his time at EMBL and the development of the organisation through a commitment to open data and nurturing scientific talent.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Welcome: Mallory Freeberg
The new Team Leader for Human Genomics at EMBL-EBI shares how curiosity and maths shaped her career and what it takes to be a community builder.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Ancient environmental DNA provides solutions for global food security challenges
Researchers explore genetic diversity found in ancient environmental DNA to help modern agricultural practices.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
IntAct reaches 1.5 million binary interaction evidences
IntAct 247 release is now public with over 1.5 million binary interaction evidences
2024
updates-from-data-resources
Case study: Discovering new enzymes to upcycle food waste
EMBL-EBI data resource helps scientists upcycle animal by-products.
SCIENCE & TECHNOLOGY2024
perspectivesscience-technology
The EMBL-EBI File Replication Archive hits 100 petabytes
A behind-the-scenes look at EMBL-EBI's in-house archive that supports major open data resources and ingests record amounts of data
2024
technology-and-innovation
DECIPHER v11.26 release
The latest DECIPHER release includes AlphaMissense scores, links to the Open Targets Platform and more.
2024
updates-from-data-resources
Predicting cancer risk on the basis of national health data
Large-scale study uses data from Danish health registries to predict individual risks of developing cancer
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
AlphaMissense data integrated into Ensembl, UniProt, DECIPHER and AlphaFold DB
The integration enables researchers to easily access AI-generated scores estimating how likely genetic variants are to be pathogenic
2024
technology-and-innovation
Calling data resource users: we need your feedback
EMBL-EBI asks users to fill in a services survey to help shape the future of the open data resources managed by the institute
2024
announcements
Expression Atlas 40 released
The latest Expression Atlas 40 release is now live, containing new RNA-seq datasets, including a featured experiment resulting from a collaboration with Genotype Tissue Expression (GTEx) project as well as new proteomics data derived from our collaboration with PRIDE. In total, this release…
2024
updates-from-data-resources
Welcome: Julio Saez-Rodriguez
EMBL-EBI's new Head of Research shares his plans and priorities.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Ensembl 112 has been released
Ensembl 112 and the corresponding release of Ensembl Genomes 59 has released. This includes exciting new fish species, many more drosophila species and new VEP updates.
2024
updates-from-data-resources
We are EMBL: María Cerezo on balancing two roles and one of EMBL’s proudest achievements
María Cerezo talks about her role as Scientific Curator, how she combines it with her position as co-chair of the Staff Association, and what she believes has been EMBL's biggest achievement in its first 50 years.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Changes to EMBL-EBI’s Senior Management Team
EMBL-EBI's Senior Management Team announces new appointment and title changes.
2024
announcements
MSD joins the Open Targets consortium
MSD joins as the latest partner in the Open Targets consortium, enhancing the initiative’s collaborative efforts in drug discovery.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
Researchers aim to use quantum computing to assemble and analyse pangenomes
Experts in quantum computing and genomics to develop new methods and algorithms to process biological data.
SCIENCE & TECHNOLOGY2024
announcementsscience-technology
Exploring cellular complexity with EMPIAR’s new cryo-electron tomography prototype browser
Data obtained through cryogenic sample electron tomography (cryo-ET) are openly available in the new Electron Microscopy Public Image Archive (EMPIAR) cryo-ET tomography browser.
EMBL ANNOUNCEMENTS2024
announcementsembl-announcements
DECIPHER v11.25 released
The latest DECIPHER update, version 11.25, introduces new key features including the integration of functional data from multiplexed assays of variant effect (MAVEs) and much more.
2024
updates-from-data-resources
‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention
New study uncovers the potential of immunotherapy in preventing breast cancer and creates the openly available Human Breast Cell Atlas.
SCIENCE & TECHNOLOGY2024
research-highlightssciencescience-technology
Using Data Hubs to analyse SARS-CoV-2 and other pathogen sequences
The SARS-CoV-2 Data Hubs are a set of tools coupled with infrastructure that support four components: the submission, analysis, presentation and visualisation of SARS-CoV-2 raw read data, and its resulting analyses. What makes Data Hubs attractive is a unique set of features: A new publication in…
2024
updates-from-data-resources
Sense makers: how standards are enabling data reuse
Data standards that have been silently enabling discovery in the life sciences for decades are now making AI advances possible.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectivesscience
AI annotations increase patent data in SureCheMBL
AI annotations added to the SureChEMBL database increase the depth of data made available to users.
2024
sciencetechnology-and-innovation
The AI revolution hinges on accessible training
Team Leader Sameer Velankar on why accessible training is key for AlphaFold and AI tools more generally.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectivesscience
MGnify Genomes mouse gut catalogue v1.0 released
The MGnify data resource for microbiome data has launched the latest MGnify Genomes catalogue comprising 112,951 genomes derived from mouse gut datasets, represented by 2,847 species-level cluster representative genomes. This catalogue was generated as part of our work with the MRC funded…
2024
updates-from-data-resources
The malaria parasite generates genetic diversity using an evolutionary ‘copy-paste’ tactic
Plasmodium falciparum, a malaria parasite, uses gene conversion to produce genetic diversity in two surface protein genes targeted by the human immune system.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
Team SAMBAI: addressing cancer disparities in recent African heritage populations
An international team of researchers aim to combine social determinants of health with genomics, immune profiling, and exposomics data to tackle cancer inequities at an unprecedented scale.
SCIENCE & TECHNOLOGY2024
announcementssciencescience-technology
First datasets available in the Federated EGA Network
The Federated European Genome-phenome Archive (FEGA) marks a significant milestone with the release of its first datasets.
2024
announcements
DECIPHER v11.24 Released
Version 11.24 of DECIPHER introduces a new ACMG/AMP pathogenicity interface for sequence variant predictions, displays ClinGen Variant Curation Expert Panel recommendations on gene pages, and updates ACMG secondary finding information to v3.2.
2024
updates-from-data-resources
We are EMBL: Jacqueline Toussaint on strange bacteria and bioinformatics
Jacqueline shares her experience of EMBL's international PhD programme.
LAB MATTERSPEOPLE & PERSPECTIVES2024
lab-matterspeople-perspectives
Europe PMC supports preprint peer review
New Europe PMC tools support preprint review discovery
2024
updates-from-data-resources
Welcome: Kyle Morris
Kyle Morris joins EMBL-EBI as Electron Microscopy Data Bank (EMDB) Team Leader.
LAB MATTERSPEOPLE & PERSPECTIVES2024
lab-matterspeople-perspectives
ProteomicsML: empowering proteomics research with machine learning
Streamlining proteomics data access for machine learning applications.
2024
sciencetechnology-and-innovation
Ensembl 111 has been released
The Ensembl 111 features a range of new Ensembl VEP plugins and updated agricultural, fish, plant and metazoa species.
2024
updates-from-data-resources
The Biodiversity Cell Atlas: charting cellular diversity on Earth
A $3.8 million grant from the Gordon and Betty Moore Foundation will help researchers lay groundwork for the Biodiversity Cell Atlas.
2024
announcements
Unravelling the role of immune cells in early lung development
Researchers reveal that healthy lung development hinges on immune-epithelial crosstalk, with implications for respiratory diseases.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
UKRI funding supports EMBL-EBI infrastructure upgrade in response to increasing data demand
UK Research and Innovation (UKRI) has confirmed £80.7 million of funding for EMBL’s European Bioinformatics Institute (EMBL-EBI). The funding comes from the UKRI Infrastructure Fund and will be distributed over the course of six years. It is set to help EMBL-EBI transform its technical…
2023
announcements
The Global Biodiversity Portal: enabling biodiversity research worldwide
The new initiative brings together genomic data from various biodiversity projects to aid conservation and biodiversity efforts.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
Extending the network of infectious disease data portals: developments in Sweden and The Netherlands
Two new data portals are set to support infectious disease monitoring and research across Europe; the Swedish Pathogens Data Portal and the Netherlands COVID-19 Data Portal.
2023
updates-from-data-resources
EMBL-EBI co-leads on research programme to help treat relapsed childhood cancers
Leading charities Children with Cancer UK and Cancer Research UK will co-fund a major £5.5 million research programme to advance precision medicine for relapsed childhood cancers.
2023
announcements
Deciphering the data deluge: how large language models are transforming scientific data curation
Large language models are changing the way we carry out scientific data curation, annotation, and research, setting the stage for a more efficient understanding of scientific literature
2023
technology-and-innovation
Starting is easy, sustaining is hard
Where to start when thinking about the sustainability of informatics projects
2023
perspectives
InterPro 97.0 released
InterPro version 97.0 and InterProScan 5.64-97.0 are now available. InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 40000 entries.
2023
updates-from-data-resources
BioImage Archive democratises access to microscopy data
Users no longer need to download large datasets with the new galleries feature
2023
updates-from-data-resources
Reducing the carbon footprint of scientific computing
As science increasingly relies on big data and AI tools, the carbon footprint of computational work is on the rise
2023
perspectives
A leap in user experience: AlphaFold Database introduces sequence-based search and structure cluster members
In response to user community demands, the AlphaFold Protein Structure database has introduced sequence-based search and cluster members.
2023
updates-from-data-resources
ggCaller: The next step in scaling up bacterial genome annotation
The Lees group develops a tool that can scale up bacterial genome annotation.
2023
research-highlights
EMBL receives German AI prize
EMBL receives the German AI prize awarded for outstanding services to the research and development as well as application and commercialisation of artificial intelligence (AI) in life science research.
EMBL ANNOUNCEMENTS2023
embl-announcementsscience
InterPro 96.0 released
InterPro version 96.0 and InterProScan 5.64-96.0 are now available.
2023
updates-from-data-resources
We are EMBL: Valentina Lorenzi on human reproductive development
PhD student Valentina Lorenzi is using single-cell sequencing data to create a map of the developing human reproductive system.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
Understanding the mechanisms of enzyme catalysis
Enzymes constitute a large fraction of genomes – 20% in humans – which makes them a very important part of life. Despite decades of studies and a rich literature dedicated to understanding the reaction mechanisms of enzymes, the rules of enzyme catalysis are still not fully clear. A new…
SCIENCE & TECHNOLOGY2023
science-technologytechnology-and-innovation
Welcome: David Hulcoop
David Hulcoop discusses how his experience bridging organisational cultures will help address critical challenges in drug discovery and target selection at Open Targets.
LAB MATTERSPEOPLE & PERSPECTIVES2023
announcementslab-matterspeople-perspectives
New predictions of genetic variant pathogenicity using AlphaFold protein structures
Ensembl Variant Effect Predictor integrates Google DeepMind’s new AlphaMissense Database for better predictions of genetic variant pathogenicity.
SCIENCE & TECHNOLOGY2023
science-technologytechnology-and-innovation
Uncovering the mechanisms underlying lack of response to immunotherapy
New research improves understanding of the molecular mechanisms behind why some cancers respond to immunotherapy and others don't.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Revealing the secrets of protein evolution using the AlphaFold database
Researchers use the AlphaFold database and Foldseek Cluster algorithm to analyse millions of predicted protein structures and offer new insights into protein evolution.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Nurturing computational excellence: the unique research culture at EMBL-EBI
EMBL-EBI’s Deputy Head of Research Virginie Uhlmann delves into the institute’s unique research landscape and the essential qualities for effective leadership in this field
2023
perspectives
From data management to AI: an interview with Laura Clarke
Experience in data management and coordination has enabled EMBL alumna Laura Clarke to pursue a career in AI development.
PEOPLE & PERSPECTIVES2023
people-perspectivesperspectivesscience
Open data to power up the blue economy
EMBL-EBI Senior Scientist Rob Finn explains why data coordination and sharing are fundamental for a sustainable blue economy.
PEOPLE & PERSPECTIVES2023
people-perspectivesperspectivesscience
Novel algorithm able to detect mutations in single-cell sequencing data sets
SComatic enables researchers to link genotype to phenotype using only single-cell profiling data
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Filling the skills gap to advance genomic medicine: an interview with Emily Perry
By upskilling researchers on bioinformatics skills and tools, EMBL alumna Emily Perry is helping to make genomic medicine more accessible.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
Ensembl Bacteria releases new annotation for all its genomes
Ensembl 110 and Ensembl Genomes 57 have introduced in-house prokaryotic gene annotation across genomes available in Ensembl Bacteria. Since its inception, Ensembl Bacteria has imported user-submitted annotations from the International Nucleotide Sequence Database Collaboration (INSDC) for…
2023
updates-from-data-resources
Latest release of the Expression Atlas
The latest Expression Atlas release is now live and contains a wider range of RNA-seq and proteomics datasets.
2023
updates-from-data-resources
refget v2.0 links the hidden dictionaries of DNA
The GA4GH standard refget quietly helps decipher millions of genomes sequenced worldwide, and it just got better.
2023
technology-and-innovation
Ensembl 110 has been released
Ensembl 100 release brings exciting updates, such as the addition of regulation data to 5 animal genomes studied extensively in agriculture.
2023
updates-from-data-resources
Latest release of IntAct and Complex Portal
We are excited to announce the latest releases of IntAct and Complex Portal. IntAct 244 highlights Complex Portal 244 highlights
2023
updates-from-data-resources
EMBL-EBI’s new building set to support data growth and innovative partnerships
Construction begins on EMBL-EBI's new building named after Janet Thornton.
EMBL ANNOUNCEMENTSLAB MATTERS2023
announcementsembl-announcementslab-matters
InterPro 95.0 released
InterPro version 95.0 and InterProScan 5.63-95.0 are now available! InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 39000 entries. InterPro version 95.0 – new features include: InterPro 95.0 covers 81.7% of UniProt Knowledgebase…
2023
updates-from-data-resources
DECIPHER database for rare diseases joins EMBL-EBI
Closer collaborations with EMBL-EBI data resources set to further develop and grow this unique rare disease platform.
EMBL ANNOUNCEMENTS2023
announcementsembl-announcementsscience
Pathogens Portal: The new gateway to public pathogen data
Enabling researchers worldwide to share and analyse pathogen data generated across the world
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
David Hulcoop appointed as Open Targets Director
Coming from a pharmaceutical industry background, David Hulcoop is set to take over as Executive Director of the public-private partnership Open Targets.
EMBL ANNOUNCEMENTS2023
announcementsembl-announcements
Europe PMC ROR integration improves grant affiliations
Better search for Europe PMC funder grants with ROR IDs
2023
updates-from-data-resources
FAIRification framework: making your data Findable, Accessible, Interoperable, and Reusable
New framework to improve the FAIRness of clinical and molecular datasets
2023
perspectives
Supporting the development of hologenomic approaches for more sustainable animal feeds
HoloFood, the first consistent collection of multiomic data about chicken and salmon gut microbiomes, set to enable the development of better animal feeds.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Major user experience update in AlphaFold Database
The AlphaFold Database boasts improved user experience, including better search filters and an improved 3D viewer.
2023
updates-from-data-resources
Genomic medicine: ushering in a new era in healthcare
EMBL-EBI data resources are being used to deliver thousands of genetic diagnostics to patients every month.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
Janet Thornton retires: a pioneer in structural bioinformatics
In recognition of Janet Thornton’s retirement, we look back at some of her biggest accomplishments shaping the field of bioinformatics.
LAB MATTERSPEOPLE & PERSPECTIVES2023
announcementslab-matterspeople-perspectives
ProtVar: understanding missense variation in humans
A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
IMAGINE-ing next-generation technology to help biologists
EMBL researchers and collaborators have begun an impactful innovation-development journey, thanks to a European Commission ‘IMAGINE’ grant.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
Cancer cell ‘decathlon’ to help predict tumour aggressiveness and metastasis
The PLAST-CELL project aims to understanding cancer progression by quantifying a cancer cell’s ability to respond to environmental stress that threatens its survival
CONNECTIONS2023
connectionstechnology-and-innovation
We are EMBL: Carolin Sauer on supporting cancer research
Postdoctoral researcher Carolin Sauer is leveraging long-read sequencing to develop new detection methods for various cancers.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesresearch-highlights
New releases: InterPro 94.0 and InterProScan 5.62-94.0
InterPro 94.0 features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38,000 entries.
2023
updates-from-data-resources
Managing a bioinformatics core facility
BioImage Archive Team Leader Matthew Hartley shares his experience and tips for people interested in managing a bioinformatics core facility.
2023
technology-and-innovation
What happens when chromosomes shatter
Understanding chromothripsis offers insights into how cancer develops.
SCIENCE & TECHNOLOGY2023
research-highlightsscience-technology
A more diverse human reference genome
The human pangenome – one of the most complete collections of genome sequences released so far – captures rich human diversity.
SCIENCE & TECHNOLOGY2023
announcementssciencescience-technology
Bioinformatics powers international effort to map gene function
EMBL-EBI is making a key contribution to a historic effort to understand the function of every human gene
LAB MATTERSSCIENCE & TECHNOLOGY2023
announcementslab-mattersscience-technology
The Human Genome Project at 20: interview with Ewan Birney
On the 20th anniversary of the Human Genome Project, we look back at its history, wonder and potential.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
EMBL alumni: Alex Almeida on the unchartered gut microbiome and becoming a principal investigator
As a postdoc Alex Almeida used bioinformatics to push the boundaries of what we know about the gut microbiome. Here, Almeida explains how his time at EMBL-EBI generated new research avenues, and how the skills and connections from his postdoc prepared him for leading his own research group at the…
PEOPLE & PERSPECTIVES2023
people-perspectivesperspectives
WormBase ParaSite 18 released
WormBase ParaSite release 18 adds largest number of new genomes and annotations since launch, as well as full integration with AlphaFold.
SCIENCE & TECHNOLOGY2023
science-technologyupdates-from-data-resources
Human genome editing: regulations, risks, and ethical considerations
Scientists have the technology to edit the human genome. But when should they, and who contributes to these decisions?
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
MAPLE: a phylogenetic tool for pandemic-scale genome data
EMBL-EBI researchers have developed a new tool capable of performing state-of-the-art phylogenetic inference on larger datasets than previously thought possible.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
Building a bioinformatics community at the nf-core hackathon
Darwin Tree of Life project improves bioinformatics tools for biodiversity data analysis
CONNECTIONS2023
connectionstechnology-and-innovation
ENA to introduce mandatory spatiotemporal annotations
The European Nucleotide Archive database introduces mandatory spatiotemporal metadata for data submissions.
2023
updates-from-data-resources
Genomic science to support conservation efforts: an interview with Lara Urban
Using long-read sequencing and machine learning approaches, EMBL alumna Lara Urban is making a difference in the field of One Health.
2023
perspectives
MGnify just got bigger – new data, new AI opportunities
EMBL-EBI's metagenomics data resource increases in size and supports groundbreaking AI tools for protein structure prediction.
2023
updates-from-data-resources
Large-scale study enables new insights into rare eye disorders
EMBL-EBI researchers use UK Biobank data to uncover new information about rare diseases of the eye.
2023
research-highlightsscience
Equality, diversity, and inclusion in science: individuals driving change
Meet some of our equality, diversity, and inclusion champions and find out how they’re making EMBL-EBI a better place to work
2023
announcements
New releases: InterPro 93.0 and InterProScan 5.61-93.0
InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38,000 entries. InterPro version 93.0 InterPro 93.0 integrates 300 new methods from the CDD (261), PANTHER (12), PROSITE profiles (17), SMART (9), TIGRFAMs (1) databases, and covers 81.7%…
2023
updates-from-data-resources
Open data for biodiversity: an EMBL-EBI 2022 round-up
As major biodiversity projects ramp up, EMBL-EBI enables genomic data sharing for all species.
2023
perspectivesscience
Latest Release of the Single Cell Expression Atlas
The Single Cell Expression Atlas (SCEA) now includes more datasets and species.
2023
updates-from-data-resources
Shedding light on rare diseases: open data and model organisms
Why open data from model organisms is essential for rare disease research.
2023
perspectivesscience
Europe PMC contributes to the Open Global Data Citation Corpus
The Open Global Data Citation Corpus will become a central place for research data citations, and include accession numbers supplied by Europe PMC.
2023
announcements
A human interactome to prioritise drug discovery
Researchers create a network of interacting proteins – or interactome – to aid drug discovery.
2023
research-highlightsscience
New Job Dispatcher website launched
EMBL-EBI’s Software Development and Operations team is delighted to announce the launch of a brand-new Job Dispatcher website, currently in development. The updated website provides a landing page for the Job Dispatcher services, making it easier for users to find and navigate services…
2023
updates-from-data-resources
Molecules to Ecosystems: Jo McEntyre on data services
Jo McEntyre talks about data services, open data and a new era for research assessment.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectivesperspectives
New EU-funded Project: Fragment-Screen
EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Congratulations to the new Sanger Institute Director
EMBL-EBI congratulates Matt Hurles on being appointed as the new Director of the Wellcome Sanger Institute.
2023
announcements
Case study: AlphaFold uses open data and AI to discover the 3D protein universe
Open data played a pivotal role in the development of the AlphaFold AI. The same open principles now apply to AlphaFold predictions.
2023
perspectivesscience
Ensembl 109 has been released
Latest Ensembl and Ensembl Genomes releases bring updates to donkey and horse assemblies, and lots of new plants and metazoa.
2023
updates-from-data-resources
BlueRemediomics: harnessing marine microbes to promote a circular bioeconomy
Funding awarded for developing tools to harness marine microbiome data for biotechnological applications and ecosystem services.
2023
announcementsscience
Leveraging long-read sequencing for cancer genomics
Genomic sequencing and big data analysis are two novel technologies driving researchers’ understanding of the complexities of cancer.
2023
perspectivesscience
PDCM Finder – an open global cancer research platform for patient-derived cancer models
Aggregating clinical, genomic and functional data from patient-derived xenografts, organoids and cell lines
2023
updates-from-data-resources
Machine learning to identify and prioritise drug targets
Open Targets is using artificial intelligence and machine learning to identify and prioritise drug targets.
SCIENCE & TECHNOLOGY2023
sciencescience-technologytechnology-and-innovation
Darwin Tree of Life: first 500 genome assemblies released as project creates a buzz
We look back through some of the 2022 highlights from the Darwin Tree of Life project.
SCIENCE & TECHNOLOGY2023
perspectivessciencescience-technology
Molecules to Ecosystems: Rob Finn on the Microbial Ecosystems transversal theme
Rob Finn, one of the co-chairs of the Microbial Ecosystems theme, discusses his work, the challenges of multidisciplinary research, and how the theme is already helping to promote the exchange of scientific ideas.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
New releases: InterPro 92.0 and InterProScan 5.60-92.0
InterPro version 92.0 and InterProScan 5.60-92.0 are now available. InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38000 entries.
2023
updates-from-data-resources
BOSS-RUNS: streamlining dynamic nanopore sequencing
A new method developed by EMBL-EBI researchers helps to streamline nanopore sequencing in real-time.
SCIENCE & TECHNOLOGY2023
research-highlightssciencescience-technology
EMBL-EBI databases considered critical to life sciences
Open data resources that enable global research and development recognised by the Global Biodata Coalition.
2022
announcementsscience
Spatial lung cell atlas offers insights into disease
Researchers have genetically profiled nearly 200,000 cells from lungs, mapping their precise locations in tissue to discover an unexpected new immune niche in our airways.
2022
research-highlights
First linked dataset on Pathogens Portal
The first cohort study linking data across categories was recently added on the Pathogens Portal Cohort Browser and is also accessible from the BioSamples browser. This pilot study comes from Erasmus Medical Centre through the ReCoDID project, one of the COVID-19 Data Platform supporting…
2022
updates-from-data-resources
EMBL-EBI appoints new Head of Technical Services
Andy Cafferkey takes on strategic role to help the institute respond to increasing demands from the global life science community.
2022
announcements
Developmental cell atlas uncovers new cell states
Unveiling a useful tool for understanding human lung development.
2022
research-highlightsscience
Genomic Data Infrastructure – integrating genomics into healthcare
EMBL-EBI supports new European Commission project set to support the use of genomics in research and healthcare.
2022
announcementsscience
Unleashing the biotechnology potential of euglenoids
An ambitious project to sequence the genomes of all known species of euglenoids will drive research on biofuels and sustainable foods.
2022
announcements
Open science for climate justice
Our experts discuss the importance of open science for food security and preserving global biodiversity.
2022
perspectivesscience
New molecular microscopy uncovers how breast cancer spreads
Researchers have created a tool that maps in previously unseen detail how breast cancer develops and spreads.
2022
research-highlightsscience
AlphaFold applications – a community assessment
Researchers use social media to share findings on how useful AlphaFold predictions are for different applications.
2022
research-highlightsscience
AI4LIFE: AI models for bioimaging
Researchers across EMBL are helping to make artificial intelligence (AI) models for bioimaging analysis interoperable and openly available to the scientific community.
2022
announcementsscience
EMBL-EBI appoints Deputy Head of Research
Virginie Uhlmann will support the Interim Head of Research in managing the institute's computational research groups.
2022
announcements
Mapping the human brain: a global collaboration
NIH BRAIN Initiative to fund brain atlases, network coordination, and knowledge sharing to explore brain function research.
2022
announcementsscience
Compare experimental and predicted structures with PDBe-KB
You can now superpose AlphaFold models onto PDB structures at the touch of a button using the PDBe-KB aggregated views of proteins.
2022
updates-from-data-resources
Ensembl 108 has been released
We are pleased to announce the release of Ensembl 108, and the corresponding release of Ensembl Genomes 55 featuring changes in the human default tracks, new genomes in Ensembl Plants and Ensembl Metazoa, and the addition of mitochondrial annotation for Tasmanian devil. Genome assemblies and…
2022
updates-from-data-resources
New releases: InterPro 91.0 and InterProScan 5.59-91.0
We are pleased to announce the release of InterPro 91.0 and InterProScan 5.59-91.0
2022
updates-from-data-resources
ArrayExpress interface now retired
Data continues to be available in BioStudies.
2022
updates-from-data-resources
Natural language processing for rapid protein annotation
Over 40 million protein annotations have been added to the UniProt database using a Google Research natural language processing model.
2022
technology-and-innovation
Funding for researchers working on plastic recycling enzymes
EMBL-EBI’s MGnify data resource helps researchers find enzymes for novel applications.
2022
announcementsscience
Biodiversity Genomics Europe: addressing biodiversity loss through genomics
European experts gather to launch a project that aims to characterise and conserve life on Earth using DNA data.
2022
announcementsscience
Ardan Patwardhan receives Scientific Achievement Award
The Royal Microscopical Society recognises Ardan Patwardhan’s contributions to the field of electron microscopy.
2022
announcements
European institutes commit to data access across borders
The Federated EGA is set to improve access to sensitive human data in a safe and secure way.
CONNECTIONS2022
announcementsconnectionsscience
In tribute to Her Majesty Queen Elizabeth II
The United Kingdom is a founding member of EMBL, and has hosted EMBL’s European Bioinformatics Institute since 1994. We recognise that the passing of Her Majesty Queen Elizabeth II will have a profound impact on the country, and we extend our deepest sympathies to the Royal Family at this…
2022
announcements
Shining a light on how bacteria interact
Machine learning has helped researchers uncover new insights into how bacteria infect host cells.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
AlphaFold predicts structure of almost every catalogued protein known to science
AlphaFold database offers a look at 3D protein universe.
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
Latvian science benefits from prospect membership
The first meeting of the Latvian Bioinformatics Forum points towards an even brighter future for the country’s role in European life sciences
CONNECTIONS2022
connectionsevents
Uncharted territories in the human genome
Scientists identify previously unexplored gene segments to be added to human genome databases.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Interactive data visualisation for Single Cell Expression Atlas
Using powerful data visualisation and interactive search results across datasets allows users to explore hypotheses across a range of metadata, and discover new insights backed by expertly curated, consistently reanalysed single cell sequencing data. Searching for metadata, allows a powerful…
2022
updates-from-data-resources
UKRI allocates funding for EMBL-EBI data resources
Funding set to support data resources for key areas of antimicrobial resistance, sustainable agriculture and biodiversity loss
2022
announcements
ArrayExpress interface to close
On 30 September 2022 the ArrayExpress interface will close. All datasets have now been migrated from ArrayExpress into the BioStudies ArrayExpress collection
2022
updates-from-data-resources
Supporting the African BioGenome Project to build bioinformatics capacity
The African BioGenome Project and EMBL have signed a Memorandum of Understanding to support each other in building genomics and bioinformatics capacity across Africa
CONNECTIONSLAB MATTERS2022
announcementsconnectionslab-matters
Impact of DNA mutations on blood cell production uncovered
Researchers discover how DNA mutations change blood cell production and how this relates to ageing and cancer development.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
A machine learning approach for allocating gene function
Researchers in the Ensembl team are making the most of machine learning methods to speed up genome annotation pipelines
SCIENCE & TECHNOLOGY2022
sciencescience-technologytechnology-and-innovation
Predicted complexes from ModelArchive now on PDBe-KB pages
New dataset of predicted protein complexes accessible through 3D-Beacons Network.
2022
updates-from-data-resources
Interpreting bioimages with deep learning
Virginie Uhlmann shares her tips for using deep learning for bioimage analysis in the life sciences.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
Guy Cochrane appointed Executive Director of Global Biodata Coalition
The GBC is a coalition of life sciences and biomedical research funders that aims to optimise the funding and management of biodata resources worldwide. The organisation has two priority aims: to better coordinate and share approaches for efficient management and growth of the biodata…
2022
announcements
The MANE collaboration: working together to support genome science
Researchers from the MANE collaboration bring you the most comprehensive human genome annotation dataset to date.
SCIENCE & TECHNOLOGY2022
research-highlightssciencescience-technology
Latest Release of the Single Cell Expression Atlas
The latest Single Cell Expression Atlas (SCEA) release is here and features collaborations with DiscovAIR and the Fly Cell Atlas
2022
updates-from-data-resources
Pathogen data sharing – key to pandemic preparedness
Researchers lay out a set of principles for open genomic data sharing or pathogens
SCIENCE & TECHNOLOGY2022
perspectivesscience-technology
Safeguarding African biodiversity through genomics
The African BioGenome Project aims to safeguard biodiversity and build bioinformatics capacity across Africa
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
New Expression Atlas release in collaboration with PRIDE
New Expression Atlas release features differential-proteomics and baseline-proteomics experiments in collaboration with the PRIDE team at EMBL-EBI. This also includes new baseline DIA proteomics experiments as well as new differential proteomics datasets. To improve reproducibility,…
2022
updates-from-data-resources
New genetic data policy must promote biodiversity conservation
Scientists urge the adoption of a sensible international policy for digital sequence information.
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Learning from Deep Learning: the inspirational story behind AlphaFold
DeepMind visits EMBL Heidelberg to discuss current and future implications of Artificial Intelligence for life science research.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
AlphaFold update – neglected tropical diseases
Latest AlphaFold database update adds 27 new organisms and almost 200,000 new protein structure predictions relevant to neglected tropical diseases and antimicrobial resistance
2022
updates-from-data-resources
Genomic data for biodiversity – a global challenge
An exploration of where in the world genomics methods are applied and where the data are used.
SCIENCE & TECHNOLOGY2022
perspectivessciencescience-technology
The Earth Biogenome Project: on track and ready to ramp up
On track to reach an ambitious goal of 3,000 genomes sequenced by the end of 2022, what’s next for the Earth Biogenome Project?
SCIENCE & TECHNOLOGY2022
announcementssciencescience-technology
Welcome: Melissa Harrison
Melissa Harrison joins EMBL-EBI as the new Team Leader of Literature Services. We found out more about her plans for open access publishing and Europe PMC.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Darwin Tree of Life in 2021: tireless fieldwork and the first beautiful genomes
A look back at some of the 2021 highlights from the Darwin Tree of Life partner institutes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Artificial intelligence — a scientific game changer in 2021
The systematic application of AI in life sciences as in the AlphaFold algorithm for predicting protein structures has been named '2021 Breakthrough of the Year' by Science magazine.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Tudor Groza
Tudor Groza joins EMBL-EBI as our new Phenomics Team Lead. We found out from Tudor exactly what this new role will entail
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Can data help feed a hungry world?
How genomics, open data, and multidisciplinary science can improve food security.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
DUO: streamlining access to biomedical datasets
The GA4GH Data Use Ontology (DUO) supports a data authorisation and access framework to streamline consent to use biomedical data
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Making sense of bacterial DNA data
A vast, curated collection of bacterial genomes is now organised, searchable and open to the community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Open data on the rise: the value of EMBL-EBI data resources
Independent study reveals that EMBL-EBI open data resources are critical for the life sciences.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
Genomic sequencing to strengthen biodiversity
The Darwin Tree of Life project is an unprecedented initiative sequencing 70,000 species
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Harnessing the microbiome to improve meat production
International project uses biomolecular data to improve animal feed and make meat production more sustainable
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Novel enzymes for a Green Economy
Using metagenomic data to find novel enzymes for plastic degradation and beyond
SCIENCE & TECHNOLOGY2021
sciencescience-technology
BY-COVID – a new EU project for pandemic preparedness
The BY-COVID project aims to make infectious disease data, including COVID-19, openly available to everyone.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
CRyPTIC: cataloguing drug resistance mutations in M. tuberculosis
Profiling M. tuberculosis strains from 27 countries to reveal causes of drug resistance.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The human genome, data sharing, and drug discovery: a career profile with Ian Dunham
Ian Dunham walks us through his career so far including working on the human genome project, seeing his work on the cover of Nature and his current role as Director of Open Targets.
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Characterising protein phosphosite function at scale
Researchers develop a new high-throughput approach to assess the functional significance of protein phosphosites.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Genomic tracking of the COVID-19 pandemic in England
Largest in-depth analysis of genomic data tracks the spread of SARS-CoV-2 lineages in England.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Proteins, art and seeing the world through a new lens
Hundreds of school children explore the beauty of proteins through art
LAB MATTERS2021
lab-matters
3D-Beacons Network: protein structure data, all in one place
3D-Beacons Network acts as a one-stop shop for protein structures by combining and standardising data from several providers.
CONNECTIONS2021
connectionsscience
The Spatial Mouse Atlas: new insights into cell fate
Researchers have combined spatial gene expression information with single-cell genomics data to create a high-resolution atlas of mouse organogenesis.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
DeepMind and EMBL release the most complete database of predicted 3D structures of human proteins
Partners use AlphaFold, the AI system recognised last year as a solution to the protein structure prediction problem, to release more than 350,000 protein structure predictions including the entire human proteome to the scientific community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Accessible 3D protein models to accelerate scientific discovery
DeepMind and EMBL-EBI to make millions of protein structure predictions freely available to the scientific community.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Great expectations – the potential impacts of AlphaFold DB
A discussion of the applications that AlphaFold DB may enable and the possible impact of the resource on science and society.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The PROTACtable genome – a new route to drug discovery
Researchers establish a framework for identifying new drugs capable of exploiting a cell’s own machinery.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Sarah Dyer
EMBL welcomes Sarah Dyer, the new Non-Vertebrate Genomics Team Leader at EMBL-EBI.
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Visualising RNA structures using R2DT
New software enables scientists to visualise RNA secondary structures using the world’s largest RNA structure dataset.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL scientists elected as EMBO Members
John Marioni, Alex Bateman, and Takashi Hiiragi have been elected to EMBO Membership.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
Genomic surveillance of SARS-CoV-2 in England
The largest in-depth analysis of genomic surveillance data mapping out the dynamics of 62 lineages of the SARS-CoV-2 virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Piecing together the best reference genome
Researchers reveal the best technology for assembling reference genomes.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Different immune responses identified in patients with COVID-19
Researchers identify differences in immune response in asymptomatic COVID-19 cases compared to those with severe symptoms
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Using metagenomic techniques to explore lichens
Researchers have used a metagenomics approach to piece together the genomes of yeasts found in wild lichens.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The value of open data for Latin American science
Scientists from the CABANA project explore how open data is benefiting global research efforts.
CONNECTIONS2021
connectionsscience
Repurposing drugs to manage COVID-19 progression
Researchers use large-scale human genetic studies to identify drug targets important for managing COVID-19 in its early stages
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Linking genetics and age-related diseases
Researchers have used human medical and genetic data from UK Biobank to investigate the genetics of age-related diseases
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Matthew Hartley
The challenges and opportunities when setting up a global archive for bioimages
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Pfam releases structures for every protein family
Thousands of new protein structure models, prected using deep learning, now available to explore
SCIENCE & TECHNOLOGY2021
sciencescience-technology
The thousands of viruses living in your gut
Scientists identify more than 140 000 virus species in the human gut; more than half have never been seen before
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Allyship and support: an interview with Janet Thornton
Professor Dame Janet Thornton discusses work–life balance, the support she has received during her career, and how organisations can help staff during the COVID-19 pandemic
LAB MATTERS2021
lab-matters
Show your support for open COVID-19 data
Open letter galvanises life science community in support of open COVID-19 data
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
Insights into the new B.1.1.7 coronavirus lineage
A new lineage of coronavirus was first identified in the UK, but why is it spreading much more rapidly within the population?
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Monitoring dangerous bacteria in freshwater
Freshwater sports can cause waterborne infections, but real-time DNA sequencing could help.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Opinion: Scientific disagreements aren’t new to COVID
Understanding why disagreement is good for COVID science. EMBL Deputy Director General Ewan Birney offers tips for sorting through the discourse.
PEOPLE & PERSPECTIVES2021
people-perspectivesscience
Discover the wonderful world of proteins: first virtual PDB Art exhibition
Schoolchildren create exquisite protein-inspired artworks
LAB MATTERS2020
lab-matters
Darwin Tree of Life: looking back on 2020
Despite restrictions, 2020 has been a busy year for the Darwin Tree of Life Project. We take a look at some of this year’s achievements and highlights.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Solving the protein structure puzzle
How artificial intelligence can help us solve the mysteries of the protein universe
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Microbiomes help predict the future of the Atlantic
Microbiomes, plastics, and connectivity – AtlantECO aims to understand the fabric of the Atlantic Ocean.
CONNECTIONS2020
connectionsscience
Bringing AI out of the black box
Why should researchers make artificial intelligence more transparent and how can they do it?
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
EOSC: shaping Europe’s digital future
EMBL’s Rupert Lück is engaged in developing the European Open Science Cloud (EOSC): the infrastructure that will support the future of data sharing and analysis in Europe.
CONNECTIONSLAB MATTERS2020
connectionslab-matters
Repurposing drugs for a pan-coronavirus treatment
Scientists from the Beltrao Group at EMBL-EBI and collaborators identified drug targets common to SARS-CoV-2, SARS-CoV-1, and MERS-CoV, three pathogenic coronaviruses. They also found potential drugs that could be repurposed as COVID-19 treatments, and against emerging coronavirus strains in the…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Achieving personalised therapeutics
A decadal roadmap points the way to cell-based medicine for Europe
LAB MATTERSSCIENCE & TECHNOLOGY2020
lab-mattersscience-technology
Genome sequencing accelerates cancer detection
The Gerstung Group at EMBL-EBI and collaborators have developed a statistical model that analyses genomic data to predict whether a patient has a high or low risk of developing oesophageal cancer.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
An organoid cell atlas to enhance biomedical research
EMBL-EBI is one of the eight European institutes involved in the Humanoid Cell Atlas initiative, a new open-access platform that combines single-cell profiling and organoid technology
EMBL ANNOUNCEMENTSLAB MATTERS2020
embl-announcementslab-matters
Welcome: Geetika Malhotra
The Web Development team provides a central source of web design and development for EMBL’s European Bioinformatics Institute (EMBL-EBI). In July, Geetika Malhotra joined the team as their new Head.
LAB MATTERSPEOPLE & PERSPECTIVES2020
lab-matterspeople-perspectives
New clues to a 500-year old mystery about the human heart
An international team of scientists involving Ewan Birney's group has investigated the function of a complex mesh of muscle fibres that line the inner surface of the heart.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
The curious genome of the tuatara, an ancient reptile in peril
A global team of researchers including the Flicek Team at EMBL-EBI has partnered up with the Māori tribe Ngātiwai to sequence the genome of the tuatara, a rare reptile endemic to New Zealand.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Bagpipe and Pokemon, or how not to name a human gene
The human genome harbours about 19 000 protein-coding genes, many of which still have no known function. As scientists unveil the secrets of our DNA, they come across novel genes that they need to refer to using a unique name. The Human Genome Organisation’s Gene Nomenclature Committee (HGNC) at…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Artificial intelligence finds patterns of mutations and survival in tumour images
Researchers have developed an artificial intelligence algorithm that uses computer vision to analyse tissue samples from cancer patients. The algorithm can distinguish between healthy and cancerous tissues, and can also identify patterns DNA and RNA changes in tumours.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unparalleled inventory of the human gut ecosystem
An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Funding to predict the risk of infectious disease outbreaks
European collaboration receives funding to explore risks and impact of future infectious disease outbreaks.
LAB MATTERS2020
lab-matters
Two EMBL scientists become EMBO Members
This year, EMBO elected 63 new members, including Alexander Aulehla, Group Leader and Senior Scientist at EMBL Heidelberg, and Paul Flicek, Associate Director of EMBL-EBI Services, Senior Scientist, Group and Team Leader at EMBL-EBI.
EMBL ANNOUNCEMENTSLAB MATTERS2020
embl-announcementslab-matters
Welcome: Ellie McDonagh
Open Targets welcomes new Informatics Science Director
LAB MATTERSPEOPLE & PERSPECTIVES2020
lab-matterspeople-perspectives
Existing drugs can prevent SARS-CoV-2 from hijacking cells
Researchers evaluate how the new coronavirus rewires human proteins for its own replication, and identify several antiviral drugs ready for clinical trials
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Five things you probably didn’t know about the Human Genome Project
Today we celebrate the 20th anniversary of the first draft of the entire human genome.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unpicking the complexity of DNA mutations
DNA damage caused by chemical mutagens is not repaired immediately and can create more genetic diversity in tumours.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Distinguishing coronavirus genome mutations from inadvertent errors
EMBL scientists have performed a large-scale analysis of over 4700 SARS-CoV-2 genome sequences. They found that many of the most interesting changes in the SARS-CoV-2 genome that have been reported so far are likely to be technical artefacts, rather than biological mutations.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
UK invests £75 million in European research infrastructure to support knowledge-based economy
The European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) and the Biotechnology and Biological Sciences Research Council (BBSRC) warmly welcome today’s announcement from the UK Government of a £75 million commitment from the Department for Business, Innovation…
LAB MATTERS2011
lab-matters
Five countries and EMBL sign Memorandum of Understanding to make ELIXIR a reality
Today marks an important step for ELIXIR, Europe’s emerging research infrastructure for life-science information, as five countries plus the European Molecular Biology Laboratory (EMBL) have signed a Memorandum of Understanding to catalyse the implementation and construction of ELIXIR. The…
LAB MATTERS2011
lab-matters
BBSRC and EMBL-EBI welcome UK funds earmarked for major bioscience data infrastructure project
The Biotechnology and Biological Sciences Research Council (BBSRC) and the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI) welcome news that funding has been earmarked from the UK’s Large Facilities Capital Fund for ELIXIR – the European Life-science…
LAB MATTERS2011
lab-matters
Making enough red blood cells
Red blood cells, the delivery men that take oxygen to cells all around the body, have short lives. To keep enough of them in circulation, the human body produces around 2 million of these cells every second – even more in response to challenges like severe blood loss. In a study published today…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
Variations on the genetic theme
Just like members of an orchestra are active at different times although playing the same piece of music, every cell in our body contains the same genetic sequence but expresses this differently to give rise to cells and tissues with specialised properties. By integrating gene expression data from…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
Open access drug discovery database launches with half a million compounds
ChEMBLdb, a vast online database of information on the properties and activities of drugs and drug-like small molecules and their targets, launches today with information on over half a million compounds. The data lie at the heart of translating information from the human genome into successful new…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
Re-write the textbooks: transcription is bidirectional
Genes that contain instructions for making proteins make up less than 2% of the human genome. Yet, for unknown reasons, most of our genome is transcribed into RNA. The same is true for many other organisms that are easier to study than humans. Researchers in the groups of Lars Steinmetz at the…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
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