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crystallography

Year
10 October 2024 A multi-coloured donut representing the structure of an NPC.

“Structurally” sound

Science & Technology The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.

2024

science-technology

7 July 2023 Cartoon of a molecule, formed by sticks and spheres.

Facilitating drug discovery against COVID-19

Science & Technology A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.

2023

sciencescience-technology

15 May 2023 Two scientists in a laboratory

Behind the scenes of innovation

EMBLetc EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.

2023

20 March 2023 Team leader Gergely Papp.

Welcome: Gergely Papp

Lab MattersPeople & Perspectives Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.

2023

lab-matterspeople-perspectives

9 January 2023

New molecular insights on medical cannabis

Science & Technology EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.

2023

sciencescience-technology

20 October 2022 Two EMBL staff members looking at a piece of equipment

Teaming up to drive forward time-resolved crystallography

Lab MattersScience & Technology The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities

2022

lab-mattersscience-technology

30 March 2021 A close-up photo of a shiny droplet of liquid that has been placed into one of the wells of a crystallisation plate.

Droplet beauty

Science & Technology Scientists at EMBL Hamburg use droplets of protein solution to grow protein crystals. By exposing the crystals to X-rays, they are able to determine the protein’s molecular structure.

2021

picture-of-the-weekscience-technology

9 February 2021 Crystal cubes seen through a microscope

Purity, beauty, and perfection

Science & Technology The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.

2021

picture-of-the-weekscience-technology

8 July 2020 The Logo of the ALPX company.

ALPX – smart crystallography

Lab Matters The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.

2020

lab-matters

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Science & Technology Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

2020

sciencescience-technology

5 May 2020 Liquid handling robot transfering protein crystalisation solutions

Responding to health threats posed by coronaviruses

Science & Technology By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.

2020

sciencescience-technology

28 April 2020 Close-up view of the interior of a protein analytics system

Exploring synthetic antibodies to stop coronavirus

Science & Technology Scientists at EMBL Hamburg and Karolinska Institutet Stockholm aim to find synthetic antibodies – known as nanobodies – that bind a surface protein of the novel SARS-CoV-2 coronavirus. Nanobodies could prevent the virus from entering human cells and causing COVID-19.

2020

sciencescience-technology

26 September 2019 The Old Port of Marseille.

EMBL and Tara: Marseille

EMBL Announcements From 27–30 September, Tara will be docked in the port of Marseille, France’s second largest city.

2019

embl-announcementsevents

17 June 2019 A photo of the Hamburg harbour at dusk

EMBL and Tara: Hamburg

EMBL Announcements EMBL Hamburg and Tara raise awareness of the risks of microplastic pollution and global infection

2019

embl-announcementsevents

22 October 2018 An 88% complete model of human hemoglobin (PDB id 5ni1) built de novo by ARP/wARP into a 3.2 Å cryo-EM map. IMAGE: Victor Lamzin/EMBL

ARP/wARP 8.0 released

Lab MattersScience & Technology Researchers at EMBL Hamburg have released the next generation of their ARP/wARP software

2018

lab-mattersscience-technology

29 January 2018 General view of the ID23-2 sample environment showing the MD3-Up diffractometer and FlexHCD sample changer. PHOTO: EMBL/J. Sinoir

Beamline ID23-2 tools up for ESRF upgrade

Lab MattersScience & Technology EMBL instrumentation teams adapting tech to run biological experiments on the synchrotron after its upgrade

2018

lab-mattersscience-technology

4 January 2018 Schematic reconstruction of the Robo1 structure. IMAGE: Andrew McCarthy / Structure

One way crossing across the midline

Science & Technology EMBL researchers solve a decades-long debate on a key process for brain and embryo-development

2018

sciencescience-technology

20 December 2017 In this representation of influenza polymerase, a molecule (white) that strongly inhibits the enzyme’s activity is shown bound to the region of the enzyme (red) that usually binds the cap section of mRNA. IMAGE: EMBL/Cusack Group

Futures: Unravelling influenza

Science & Technology ERC grantee Stephen Cusack shares his vision for the next ten years

2017

sciencescience-technology

16 February 2017

Beamline 14’s legacy

Lab MattersScience & Technology Beamline BM14 in Grenoble shuts down, continues collaboration with India

2017

lab-mattersscience-technology

25 January 2017 Wojciech Galej, new group leader at EMBL

Welcome: Wojciech Galej

People & Perspectives New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression

2017

people-perspectivesscience

20 December 2016 A 3D print-out of beta-galactosidase

Happy anniversary, PDBe!

Lab MattersScience & Technology Ewan Birney's nine "Structures of Christmas" celebrate 20 years of PDBe

2016

lab-mattersscience-technology

14 December 2016

New Crystallography platform inaugurated

EMBL AnnouncementsLab Matters A new crystallography platform in Grenoble opens the door to new technological developments

2016

embl-announcementslab-matters

2 December 2016

Catching the chaperone in the act

Science & Technology How Christian Löw’s failed experiment led to an unexpected scientific journey

2016

sciencescience-technology

13 September 2016

New drug candidate unleashed for TB

Science & Technology EMBL researchers help to design a lead compound active against four different pathogens

2016

sciencescience-technology

13 September 2016

Opinion: 2006, a year of champagne

Lab MattersPeople & Perspectives Stephen Cusack looks back on the early days of his collaboration with Anacor developing anti-infectives

2016

lab-matterspeople-perspectives

30 August 2016

Atomic proportions

Connections EMBL and ESRF scientists and mechanics work together on upgrade for one of Europe’s big X-ray sources

2016

connectionsscience

10 May 2016 A small loop (green) of the atomic structure of DAPK shown to be crucial for dimer formation and binding with its signaling partner Calmodulin. IMAGE: Petra Riedinger/EMBL

Enzyme with a dual-purpose loop

Science & Technology Unexpected results: structure of DAPK enzyme reveals dual-purpose loop

2016

sciencescience-technology

21 April 2016 Florent Cipriani (right) developed CrystalDirect™ together with Josan Marquez (left) PHOTO: EMBL

The man behind the machine

Science & Technology Florent Cipriani talks about his passion for developing beamline instrumentation

2016

sciencescience-technology

21 April 2016 CrystalDirect robot control software: signal from a video camera monitoring the laser working area within a microplate (centre), used to locate the aperture (green trace) and cutting shape (red line), and to select final position of pin tip relative to the crystal (red oval). IMAGE: Zander, U, et al.

Crystals in the beamlight

Science & Technology CrystalDirect, developed at EMBL, automates crystal preparation for X-ray analysis

2016

sciencescience-technology

7 March 2016 During cell division, DNA (purple) must be correctly grouped and divided between daughter cells. IMAGE: Nasser Rusan, National Institutes of Health (NIH)

A cohesive structure

Science & Technology Structural insights into how cohesin keeps DNA together during the cell cycle

2016

sciencescience-technology

11 February 2016 The 3D structure shows how two transcription factors influence one another’s binding to a specific stretch of DNA – an interaction that is crucial for a heart to develop healthily. IMAGE: EMBL/C.Müller

True Love

Science & Technology How transcription factors interact to create a heart

2016

sciencescience-technology

4 February 2016 Rob Meijers and Stephane Boivin at the Sample Preparation and Characterisation facility. PHOTO: EMBL/Rosemary Wilson

How to make a protein happy

Science & Technology Protein screens developed at EMBL Hamburg now commercially available

2016

sciencescience-technology

18 January 2016 A peroxisome containing protein crystals is hit by a free-electron laser. IMAGE: EMBL/CFEL, Thomas Seine

The cellular crystal factory

Science & Technology Hamburg collaborators analyse protein crystals inside the cells that made them.

2016

sciencescience-technology

15 January 2016 Full length CTP1L protein (green) in complex with truncated C-terminal domain (violet). IMAGE: Rob Meijers

One gene, two proteins, one complex

Science & Technology Further insights into how viral enzymes degrade the cell walls of Clostridia bacteria.

2016

sciencescience-technology

23 November 2015 More than 600 'diplomas' were awarded to budding crystallographers for successfully fishing crystals! PHOTO: DESY 2015

High-throughput event

Lab Matters Energy, enthusiasm and endurance on tap as thousands attend 12-hour Hamburg Night of Science.

2015

eventslab-matters

22 September 2015

MASSIFly efficient

Science & Technology MASSIF-1 processes its 10,000th crystal, less than one year after the beamline became operational.

2015

sciencescience-technology

16 July 2015

Oskar’s structure revealed

Science & Technology 3D structure of Oskar protein gives first molecular insight into how it functions.

2015

sciencescience-technology

18 June 2015

From mountains to molecules

Staff, alumni, partners and more meet at EMBL Grenoble to celebrate Outstation's 40th anniversary.

2015

events

21 May 2015

It runs in the family

Science & Technology Detailed structural study shows distantly related viruses share a common machinery for replication.

2015

sciencescience-technology

26 January 2015

Light years ahead

Science & Technology As EMBL Hamburg celebrates 40 years, we explore the past, present and future of crystallography.

2015

sciencescience-technology

26 January 2015

It all started with muscle…

Lab Matters Ken Holmes, one of the visionaries behind EMBL and EMBL Hamburg, looks back to where it all began.

2015

alumnilab-matters

9 January 2015

Welcome: Marco Marcia

Science & Technology New group leader Marco Marcia aims to broaden horizons while mapping molecules.

2015

sciencescience-technology

11 December 2014

Lighting the way

EMBL Hamburg celebrates four decades of vision, pioneering research and beamline services.

2014

events

28 November 2014

MASSIF step forward

Science & Technology In two months, 2.3 million diffraction images collected on new, fully automated ESRF/EMBL beamline.

2014

sciencescience-technology

19 November 2014

20 years in the making

Science & Technology First complete picture of flu virus polymerase. A story of two decades of blood, sweat and sneezes.

2014

sciencescience-technology

4 November 2014

Zombies and crystals

Open Day in Grenoble celebrates crystallography for the Fête de la Science.

2014

events

3 November 2014

PEPC recipe for success

How to make good quality samples for good quality structural biology experiments.

2014

events

20 August 2014

Binding bracelet

Science & Technology Vasa protein preserves pieces of 'enemy' DNA to help protect the genes of future generations.

2014

sciencescience-technology

8 August 2014

International connections

Science & Technology How a single molecule can attract and repel growing brain connections

2014

sciencescience-technology

24 July 2014 C. diff bacterium

Fighting bacteria – with viruses

Science & Technology Molecular switch enables viruses to destroy C.diff bacteria – potential alternative to antibiotics

2014

sciencescience-technology

1 July 2014

The future’s bright

Science & Technology Surprising protein from a flu-like virus is 10 000th ESRF structure

2014

sciencescience-technology

1 July 2014

The shape of things to come

Science & Technology New ways of handling and distributing data at PDBe to tackle ever larger and more complex proteins

2014

sciencescience-technology

1 July 2014 Illustration: Aad Goudappel, Rotterdam

Five for the future

Lab Matters Scientists from EMBL's five sites reflect on the opportunities and challenges that might lie ahead

2014

lab-matters

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