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cancer

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22 March 2023 Artistic representation that features a long, winding helix joining together a doughnut-figure to a small shaggy ball to indicate the connections long-read sequencing can make about DNA mutations.

The ‘long read’ for cancer

Science Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.

2023

science

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

Connections, Lab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

2021

connectionslab-matters

1 April 2020

Understanding brain tumours in children

Science, Science & Technology The causes of 40 percent of all cases of certain medulloblastoma – dangerous brain tumours affecting children – are hereditary. These are the findings of a recent genetic analysis carried out by scientists from EMBL and numerous colleagues around the world.

2020

sciencescience-technology

5 February 2020

Protecting data in the cloud

Science, Science & Technology Cloud computing offers unprecedented opportunities for global-scale research collaborations. It also presents a unique set of challenges in terms of data protection and the ethics of data sharing.

2020

sciencescience-technology

5 February 2020

Cancer mutations occur decades before diagnosis

Science, Science & Technology Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI) and the Francis Crick Institute have analysed the whole genomes of over 2600 tumours from 38 different cancer types to determine the chronology of genomic changes during cancer development.

2020

sciencescience-technology

31 December 2019

Tumour takeover

Picture of the week, Science & Technology Breast cancer is the second leading cause of cancer-related deaths in women. It is so deadly because tumours often return after successful cancer treatment. This recurrence is caused by individual dormant cancer cells remaining inside the breast. These cells can develop into active cancer cells…

2019

picture-of-the-weekscience-technology

21 May 2019

From fruit flies to cancer treatment

Picture of the week, Science & Technology This image – resembling a network of rivers and canals – actually shows the tracheal tip cell of a fruit fly. Fruit flies are heavily used in research and they are a common model organism in developmental biology. Researchers at EMBL use the larvae of fruit flies to study tracheal cell…

2019

picture-of-the-weekscience-technology

25 September 2013

Without a trace

Science, Science & Technology Migrating cells, it seems, cover their tracks not for fear of being followed, but to keep moving forward. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have now shown that cells in a zebrafish embryo determine which direction they move in by effectively…

2013

sciencescience-technology

11 August 2013

From fireman to arsonist

Science, Science & Technology Like a fireman who becomes an arsonist, a protein that prevents cells becoming cancerous can also cause tumours, scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered. The finding, published today in Nature Structural and Molecular Biology, stems…

2013

sciencescience-technology

19 January 2012 Artist's impression of a chromosome exploding

Rigged to explode?

Science An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University…

2012

science

12 January 2012

Evolution by ‘copy-paste’

Science A team of geneticists and computational biologists at the European Molecular Biology Laboratory’s European Bioinformatics Institute (EMBL-EBI), the Wellcome Trust Sanger Institute and Cancer Research UK reveal how an ancient mechanism is involved in gene control and continues to drive genome…

2012

science

13 September 2009 In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Science Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

2009

science

8 April 2008

An unexpected way to cause leukaemia

Science Leukaemia – cancer of blood or bone marrow – is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. To devise effective therapies it is crucial to know which mutations cause leukaemia and which cell type gives rise to leukaemic cells. Researchers from…

2008

science

21 October 2007

Scientists uncover how hormones achieve their effects

Science New insights into the cellular signal chain through which pheromones stimulate mating in yeast have been gained by scientists at the European Molecular Biology Laboratory [EMBL]. Similar signal chains are found in humans, where they are involved in many important processes such as the…

2007

science

12 February 2007

A signal that protects the liver from hepatitis and cancer

Science Liver cancer is one of the deadliest cancers worldwide; every year sees more than 400,000 new cases, and most of the victims die in less than one year. Despite extensive research, the underlying molecular mechanisms of the disease are poorly understood. A new study by researchers from the Mouse…

2007

science

3 September 2006

Lost in the labyrinth

Science Blood cells have limited lifespans, which means that they must be continually replaced by calling up reserves and turning these into the blood cell types needed by the body. Claus Nerlov and his colleagues at the European Molecular Biology Laboratory (EMBL) unit in Monterotondo, Italy, in…

2006

science

25 August 2006

A switch between life and death

Science Cells in an embryo divide at an amazing rate to build a whole body, but this growth needs to be controlled. Otherwise the result may be defects in embryonic development or cancer in adults. Controlling growth requires that some cells divide while others die; their fates are determined by signals…

2006

science

9 August 2006

EMBL scientists found start-up company to develop anti-cancer drugs

Lab Matters Today EMBL scientists, EMBL’s commercial affiliate, EMBL Enterprise Management Technology Transfer GmbH (EMBLEM) and EMBL’s venture vehicle, EMBL Ventures GmbH, announce the foundation of Elara Pharmaceuticals GmbH, a start-up company that will translate basic research findings into new…

2006

lab-matters

4 September 2005

A new link between stem cells and tumors

Science Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in…

2005

science

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