Cerelixis: precision phytostimulants for resilient agriculture
A new EMBL spin-off leverages new insights into plant biology for more efficient crop protection
SCIENCE & TECHNOLOGY2025
science-technology
Knowledge exchange between continents supports infection biology research
African scientists awarded the 2024 EMBL-UNESCO residencies share their experience in bioinformatics and virology, emphasising the power of connections and knowledge exchange.
CONNECTIONSPEOPLE & PERSPECTIVES2025
connectionspeople-perspectives
Splicing twins: unravelling the secrets of the minor spliceosome complex
Researchers in the Galej Group at EMBL Grenoble have provided new insights into the structure of the minor spliceosome, an essential RNA-protein complex.
SCIENCE & TECHNOLOGY2025
science-technology
Structural insights reveal drug target in trypanosome parasites
The Kowalinski group at EMBL Grenoble identified significant differences between the trypanosomal and human nuclear cap-binding complex, a key player in cellular RNA metabolism and a potential target for novel anti-parasitic drugs.
SCIENCE & TECHNOLOGY2025
science-technology
Cute molecules and the scientists who adore them: Sarah Gharbi
Sarah Gharbi, technician at EMBL Grenoble, talks about her favourite protein complex, which looks like a poodle. This is part of a series of stories about EMBL scientists and quirky, charming proteins that make them smile.
PEOPLE & PERSPECTIVES2025
people-perspectives
We are EMBL: Romain Linares on the infinitely small and the infinitely large
Romain Linares talks about his role in managing the cryo-electron microscopy facility at EMBL Grenoble, how he sees this technique evolving in the coming years, and his passion for astronomy.
PEOPLE & PERSPECTIVES2024
people-perspectives
Diving into the world of science
EMBL Grenoble took part in a series of activities during the French Science Week, highlighting EMBL’s research and the TREC scientific expedition.
LAB MATTERS2024
lab-matters
Making in situ serial crystallography more accessible
Nicolas Foos, a postdoctoral fellow at EMBL Grenoble, talks about the implementation of a new method for in situ serial crystallography developed during his ARISE fellowship.
SCIENCE & TECHNOLOGY2024
science-technology
“Structurally” sound
The function of biological molecules is intimately linked to their structure. In the 50 years since EMBL was established, its researchers and engineers have constantly provided leadership in structural biology research and services, resulting in many scientific breakthroughs and novel insights.
SCIENCE & TECHNOLOGY2024
science-technology
Computational protein design and protein structure prediction win Nobel Prize in Chemistry
Creators of AI system AlphaFold receive 2024 Nobel Prize for Chemistry.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
Machine learning discoveries honoured with 2024 Nobel Prize for Physics
The prize was awarded to John J. Hopfield, Princeton University, USA, and Geoffrey Hinton, University of Toronto, Canada, for their seminal contributions to the foundational methods that enabled the development of machine learning.
SCIENCE & TECHNOLOGY2024
science-technology
New insights on how bird flu crosses the species barrier
A new publication from the Cusack group sheds light on how a key avian influenza virus enzyme can mutate to allow the virus to replicate in mammals.
SCIENCE & TECHNOLOGY2024
science-technology
Developing a simple, cost-effective method to study an important protein modification
EMBL Grenoble researchers have come up with a new way to identify the targets of a crucial protein-modifying enzyme involved in diverse cellular processes.
SCIENCE & TECHNOLOGY2024
science-technology
We are EMBL: Melanie Schneider on changing career trajectory
ARISE fellow Melanie Schneider shares how she uncovered a new interest in research infrastructures and supporting discovery.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Celebrating 50 years of infinite curiosity
What makes EMBL unique? Among many things, it’s the infinite curiosity of its community.
LAB MATTERS2024
lab-matters
IIT-EMBL: New molecules to modulate gene expression
A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.
SCIENCE & TECHNOLOGY2024
science-technology
An enzyme with a smart friend
EMBL Grenoble’s Kowalinski Group analysed the structure of an enzyme responsible for modifying tRNA molecules to fine-tune protein production. They discovered that to distinguish almost identical, yet different, tRNA molecules, the enzyme uses help from another enzyme – a type of cooperation…
SCIENCE & TECHNOLOGY2024
science-technology
AI approaches in structural biology and drug discovery
EMBL Grenoble and the ESRF hosted a workshop bringing together representatives from research and industry to discuss the ever-growing role of artificial intelligence in the field of structural biology.
CONNECTIONS2024
connections
We are EMBL: Elise Bralet on the importance of connecting people
Elise talks about her role in supporting EMBL Grenoble staff in daily human resources matters and the multiple events she’s been involved in to connect people, both at and outside of work.
PEOPLE & PERSPECTIVES2024
people-perspectives
Stephen Cusack: what I’ve learned
Stephen Cusack, world-renowned structural biologist and former Head of EMBL Grenoble, reflects on his early influences, his achievements, and the lessons he’s learned as he embarks on his next adventure
PEOPLE & PERSPECTIVES2024
people-perspectives
Building the cell’s splicing machine
New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.
SCIENCE & TECHNOLOGY2024
science-technology
Studying the relationship between cancer-promoting proteins
A new study from the Bhogaraju Group at EMBL Grenoble reveals how the cancer-promoting MAGE family of proteins bind to their targets, aiding the development of anti-cancer drugs that target these proteins.
SCIENCE & TECHNOLOGY2024
sciencescience-technology
EMBL and UGA signed the renewal of their agreement for the delivery of a doctoral degree
The two institutions celebrated the renewal of the partnership agreement initiated in 1999 for the delivery of a doctoral degree and a joint training certificate during UGA’s Welcome Day for doctoral students.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
We are EMBL: Victor Armijo on instrumentation in supporting research
Victor Armijo, a mechatronics engineer at EMBL Grenoble, talks about his dream job, highlighted in EMBL’s exhibition ‘The World of Molecular Biology’.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Looking back on 20 years of structural biology collaboration in Grenoble
On this date (15 November), 21 years ago, the EMBL, ESRF, ILL, and IBS directors signed a memorandum of understanding to create the Partnership for Structural Biology (PSB) on the European Photon and Neutron (EPN) science campus in Grenoble.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
Enjoying a science day in Grenoble
EMBL Grenoble was once again present for the science outreach event ‘Parvis des Sciences’ on Saturday 14 October 2023.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
A promising target to fight inflammatory bowel diseases
Researchers from the Cusack group at EMBL Grenoble provide structural insights on the XIAP/RIPK2 complex, a promising drug target to fight inflammatory bowel diseases.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Celebrating Stephen Cusack’s contributions to science
Researchers from across the globe have gathered in Grenoble to celebrate the remarkable lifelong scientific achievements of Stephen Cusack, the former head of EMBL Grenoble.
PEOPLE & PERSPECTIVES2023
eventspeople-perspectives
Switching off the cytokine storm
EMBL Grenoble and University of Geneva researchers shed light on the molecular activation of the MAP kinase p38α, the final ‘switch’ triggering the inflammatory response.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
We are EMBL: Rutuja Yelmar on her life as a PhD student at EMBL Grenoble
Rutuja Yelmar, predoctoral Fellow at EMBL Grenoble in the Kowalinski group, talks about her passion for research, daily inspiration, and the importance of collaboration in achieving her goals.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Spotlight: Shedding light on deadly parasites
This single-celled organism the size of a dust particle is capable of causing deadly tropical diseases in both humans and livestock –Trypanosoma brucei, in an image by Luciano Dolce from EMBL.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-matterspicture-of-the-weekscience-technology
Facilitating drug discovery against COVID-19
A collaboration between EMBL Grenoble and EBRIS scientists led to the characterisation of a new compound with promising activity against SARS-CoV-2 variants.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
IMAGINE-ing next-generation technology to help biologists
EMBL researchers and collaborators have begun an impactful innovation-development journey, thanks to a European Commission ‘IMAGINE’ grant.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
We are EMBL: Martin Pelosse on his role at the Eukaryotic Expression Facility
Martin Pelosse, Scientific Expert at EMBL Grenoble Eukaryotic Expression Facility, explains the platform’s role in supporting the site’s cutting-edge research activities and its future applications.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Behind the scenes of innovation
EMBL Grenoble technology teams provide a sneak peek into their latest collaborative project in structural biology services: the complete automation of an integral step in X-ray crystallography.
EMBLetc2023
We are EMBL: Angelika Thomasson on administrative support to EMBL staff
Angelika Thomasson, administrative assistant at EMBL Grenoble, talks about her role in supporting her colleagues in organising events and travels, what she enjoys about EMBL, and which famous female scientist she would like to have coffee with.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
We are EMBL: Audrey Spielmann on providing lab support
Audrey Spielmann, Lab Support Manager, talks about her role in supporting the research done at EMBL Grenoble.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
Welcome: Gergely Papp
Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.
LAB MATTERSPEOPLE & PERSPECTIVES2023
lab-matterspeople-perspectives
EMBL Grenoble showcased at Biophysical Society Meeting
EMBL’s French site was highlighted in a short film presenting its expertise in structural biology research and services.
CONNECTIONSLAB MATTERS2023
connectionslab-matters
New EU-funded Project: Fragment-Screen
EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Solving the structure of a critical molecular editor
EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
New molecular insights on medical cannabis
EMBL Grenoble researchers have investigated the interaction between THC and some proteins it might bind to. In a recent study, they showed in vitro that THC inhibits an important human enzyme called autotaxin.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Celebrating science in Grenoble
In October 2022, EMBL Grenoble participated in the annual science outreach event Parvis des Sciences, organised by the GIANT campus under the umbrella of the French science week – La Fête de la science.
CONNECTIONSLAB MATTERS2022
connectionslab-matters
Getting closer to stopping toxoplasmosis infection
Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Two in one: combining MASSIF-1 and CrystalDirect
Researchers and engineers have integrated a CrystalDirect harvester into the fully automated beamline MASSIF-1, a unique combination of structural biology technologies that is now open to external academic users.
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Teaming up to drive forward time-resolved crystallography
The recent construction of the new ID29 beamline in Grenoble is pioneering a new way of doing experiments in time-resolved crystallography and opening up technology transfer possibilities
LAB MATTERSSCIENCE & TECHNOLOGY2022
lab-mattersscience-technology
Next Head of EMBL Grenoble appointed
Professor Kristina Djinović-Carugo has been appointed as the next head of EMBL Grenoble. She will join EMBL in July from the Max Perutz Laboratories at the University of Vienna, where she is currently Head of the Department of Structural and Computational Biology and full Professor of Structural…
EMBL ANNOUNCEMENTSLAB MATTERS2022
embl-announcementslab-matters
Meet the next Head of EMBL Grenoble
Slovenian structural biologist Kristina Djinović-Carugo will join EMBL in July as the new Head of EMBL Grenoble. We spoke to her about her background, research interests, and plans for EMBL Grenoble.
LAB MATTERSPEOPLE & PERSPECTIVES2022
lab-matterspeople-perspectives
Capturing ‘snapshots’ of a crucial step in RNA splicing
The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
EMBL-IAB collaboration on the rise
The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Solving molecular puzzles to find the perfect fit
Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Strengthening collaborations in France
EMBL and the French National Centre for Scientific Research (CNRS) signed a memorandum of understanding.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Wrangling an octopus-like viral replication machine
EMBL structural biology is part of an international collaboration addressing zoonotic disease caused by Lassa virus.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL experimental services enable European researchers to tackle global societal challenges
Independent impact review finds EMBL experimental services are ‘critical’ for research and endorses EMBL as a world-class service provider for academia and industry.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
EMBL and Ifremer cooperate to advance ocean sciences
The two organisations have signed a memorandum of understanding to support scientific cooperation in the exploration of coastal and oceanic ecosystems.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Six Ways to Protect the Planet Against Pandemics*
EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.
SCIENCE & TECHNOLOGY2021
eventsscience-technology
MASSIF-1 beamline in Grenoble supports COVID-19 drug discovery
MASSIF-1, run jointly by EMBL Grenoble and the ESRF, is a beamline for macromolecular crystallography. It is used by the research community to study the 3D structure of proteins, which is important for drug development.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
A hidden medal
We all like a story about rediscovering treasures, right? Well, that’s just what happened recently at EMBL Grenoble!
PEOPLE & PERSPECTIVES2021
alumnipeople-perspectives
EMBL and Inserm to join forces
A memorandum of understanding has been signed between EMBL and Inserm to strengthen their scientific cooperation.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
EMBL and Tara Ocean Foundation sail forward with formalised cooperation
The EMBL-Tara Ocean Foundation collaboration will expand opportunities to jointly explore molecular connections between ocean and humankind.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
EMBL strengthens collaborations in the French academic landscape
A memorandum of understanding has been signed between EMBL, Collège de France, and the Institute of Biology of the Ecole Normale Supérieure (IBENS).
CONNECTIONSLAB MATTERS2021
connectionslab-matters
Structural biology at EMBL: driving technology development
Florent Cipriani, who recently retired as Head of the Instrumentation Team after a long career at EMBL Grenoble, is one of the pioneers of instrumentation development in this field.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
From molecules to ecosystems: EMBL and IAB sign memorandum of understanding
This MoU formalises a 15-year collaboration between the two institutes and strengthens Grenoble as a European research centre in the life sciences.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
Touch of springtime in Grenoble
This photo shows the European Photon and Neutron (EPN) science campus where EMBL Grenoble is located. A delightful spring breeze in the air melts the last remaining patches of snow in the mountains.
LAB MATTERS2021
lab-matterspicture-of-the-week
Purity, beauty, and perfection
The regular structures of crystals are a source of inspiration and fascination to us humans. While the crystals in this picture were not grown in nature, but instead by Petra Drncova from EMBL Grenoble, they share the same attributes as those found in nature.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
At the core of the Integrator complex
A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL becomes newest Instruct Centre
EMBL’s sites in Grenoble, Hamburg, and Heidelberg form the newest Instruct Centre. The new centre offers users access to a broad range of state-of-the-art facilities.
CONNECTIONSLAB MATTERS2021
connectionslab-matters
First powder over EMBL Grenoble
The first snowflakes have fallen on the Vercors Mountains, right behind the EMBL Grenoble building, and an almost full moon is showing up during a sunny morning.
LAB MATTERS2020
lab-matterspicture-of-the-week
EMBL forms new collaborations in France
EMBL and CIML have signed a memorandum of understanding that will open up new scientific opportunities.
CONNECTIONSLAB MATTERS2020
connectionslab-matters
EMBL scientists receive prestigious ERC Starting Grants
Maria Bernabeu and Wojciech Galej have each been awarded €1.5 million to research malaria and pre-mRNA splicing, respectively.
EMBL ANNOUNCEMENTSLAB MATTERS2020
embl-announcementslab-matters
Upgraded beamlines at EMBL Grenoble unveiled
The beamlines run jointly by EMBL Grenoble and the ESRF reopen today, unveiling significant upgrades that exploit the brand new fourth generation ESRF synchrotron source.
EMBL ANNOUNCEMENTS2020
embl-announcementsscience
ALPX – smart crystallography
The CrystalDirect® technology, combined with the web-based CRIMS software enable a fully automated, remote-controlled protein-to-structure pipeline.
LAB MATTERS2020
lab-matters
Investigating the structure and mechanisms of coronavirus biomolecules
While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Genetic cut and paste at atomic resolution
Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Facilitating COVID-19 structural biology research
EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…
CONNECTIONS2020
connectionsscience
Responding to health threats posed by coronaviruses
By re-opening the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble, EMBL is supporting structural biology projects to respond to the health threats posed by coronaviruses.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Remote access to EMBL structural biology pipelines to support research on SARS-CoV-2
The Marquez Team has restarted operations at the High-Throughput Crystallisation (HTX) lab at EMBL Grenoble. The team has developed a fully automated protein-to-structure pipeline, which can be operated remotely and provides virtual access to the facilities.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
It’s Lab Ski Day!
This image, taken by Raphaël Cohen-Aberdam from the Cipriani team, shows that the weather for the Grenoble Lab Ski Day 2020 was just perfect!
LAB MATTERS2020
lab-matterspicture-of-the-week
The end of a productive day
It’s evening and the Sun is setting over the mountains surrounding the city of Grenoble – home to one of EMBL’s six sites – bathing the mountaintops in fiery red light. The Picture of the Week, taken by Zuzanna Kaczmarska shows the lab she worked in after a long and busy day. Bottles…
LAB MATTERS2019
lab-matterspicture-of-the-week
New distributed research infrastructure for structural biology
Breakthroughs in biomedical science are a step closer today, with the launch of a new distributed research infrastructure for the science of structural biology: Instruct. The launch of Instruct will give academic and commercial scientists across Europe access to a full portfolio of integrated…
SCIENCE & TECHNOLOGY2012
sciencescience-technology
How cells export and embed proteins in the membrane
Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
One-touch make-up – for our cells
The cells in the different parts of this video are always the same (grey), but, like actors using make-up to highlight different facial features, they have fluorescent labels that mark different cellular components in different colours: blue shows the nucleus, yellow shows tubulin (a component of…
SCIENCE & TECHNOLOGY2010
sciencescience-technology
Putting the squeeze on sperm DNA
In the quest for speed, olympic swimmers shave themselves or squeeze into high-tech super-suits. In the body, sperm are the only cells that swim and, as speed is crucial to fertility, have developed their own ways to become exceptionally streamlined. Scientists at the European Molecular Biology…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
Getting a grip on complexes: EMBL scientists develop first fully automated pipeline for multiprotein complex production
Most cellular processes are carried out by molecular machines that consist of many interacting proteins. These protein complexes lie at the heart of life science research, but they are notoriously hard to study. Their abundance is often too low to extract them directly from cells and generating…
SCIENCE & TECHNOLOGY2009
sciencescience-technology
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