Machine learning algorithm brings long-read sequencing to the clinic
SAVANA is a new tool designed for accurate detection of structural variations in clinical samples.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
Understanding rare diseases with digital twins
New EMBL-EBI project explores the use of a concept developed in aerospace engineering to support rare disease research, diagnosis, and treatment.
PEOPLE & PERSPECTIVES2025
people-perspectivestechnology-and-innovation
Knowledge exchange between continents supports infection biology research
African scientists awarded the 2024 EMBL-UNESCO residencies share their experience in bioinformatics and virology, emphasising the power of connections and knowledge exchange.
CONNECTIONSPEOPLE & PERSPECTIVES2025
connectionspeople-perspectives
We are EMBL: Francesco Costa on protein design and the EMBL PhD programme
Francesco talks about his work in protein science, fascination for protein design, and how he's finding the EMBL International PhD programme.
PEOPLE & PERSPECTIVES2025
people-perspectivesperspectives
BioChatter: making large language models accessible for biomedical research
Introducing an open-source large language model (LLM) framework designed for custom biomedical research.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
Researchers uncover what drives aggressive bone cancer
Study identifies a novel mechanism driving osteosarcoma and provides insights to help predict patient outcomes.
SCIENCE & TECHNOLOGY2025
research-highlightsscience-technology
Human immune system is ‘ready to go’ long before birth
The most comprehensive map of the developing human thymus sheds light on how immune responses are built and maintained during early life
2024
announcements
Cancer drug resistance causes and categories identified
Researchers uncover that DNA changes that cause cancer drug resistance can be grouped into four categories, and identify possible new therapeutic targets.
2024
announcements
We are EMBL: Iguaracy Pinheiro-de-Sousa on organoids and nanorobot ‘highways’
EMBL-EBI Postdoctoral researcher Iguaracy Pinheiro de Sousa is using bioinformatics to support the development of better organoids.
PEOPLE & PERSPECTIVES2024
people-perspectivesperspectives
Why clinical trials stop: the role of genetics
Using machine learning to analyse the genetic factors behind early clinical trial termination, researchers find a link between genetic evidence and trial outcome.
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
Predicting cancer risk on the basis of national health data
Large-scale study uses data from Danish health registries to predict individual risks of developing cancer
SCIENCE & TECHNOLOGY2024
research-highlightsscience-technology
‘Exhausted’ immune cells in healthy women could be target for breast cancer prevention
New study uncovers the potential of immunotherapy in preventing breast cancer and creates the openly available Human Breast Cell Atlas.
SCIENCE & TECHNOLOGY2024
research-highlightssciencescience-technology
Unveiling the vulnerabilities of pulmonary neuroendocrine tumours
A new organoid model mimics the behaviour of neuroendocrine tumours (NETs), providing a novel and invaluable tool to study the disease in the lab.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
New therapies to improve cardiovascular health
EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
When microbiomes collide
EMBL researchers used data from over 300 human faecal microbiota transplants to gain an ecological understanding of what happens when two gut microbiomes clash.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Cell sorting enters a new dimension
EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
The impact of drugs on gut microbes is greater than we thought
Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…
SCIENCE & TECHNOLOGY2021
sciencescience-technology
From stem cells to neurons
Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Unravelling epigenetic reprogramming
A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
New insights into epigenetic modifications
Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Genetic cut and paste at atomic resolution
Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Re-trafficking proteins to fight Salmonella infections
Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Enabling functional genomics studies in individual cells
Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
New insights into gene regulation
EMBL researchers investigate the role of a histone protein in regulating gene expression
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Finding your way around Platynereis dumerilii
EMBL researchers combine multiple datasets to develop expandable atlas of an entire animal
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How transcription factors work together
EMBL researchers have developed a method to observe interactions between transcription factors
SCIENCE & TECHNOLOGY2020
sciencescience-technology
A classification tool for transcription factors
The software diffTF quantifies activity of transcription factors and predicts their mode of action
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Understanding a key player in melanoma
A new paper describes a unique mechanism of partner selectivity in transcription factors.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Photo-micropatterning advances structural cell biology
A new technique in cryo-EM
SCIENCE & TECHNOLOGY2019
sciencescience-technology
New perspectives on nuclear pores
EMBL researchers have published two new studies involving the nuclear pore complex
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Transcriptional hubs confer phenotypic robustness
Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A tRNA modifier at work
Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Actin crosslinking plays key role in tissue morphogenesis
New insights into mechanisms behind embryonic development
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Hydraulic force shapes mammalian embryos
Uncovering new role of fluid pressure in controlling embryo size and cell fate
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Breaking the bottleneck in imaging data collection
Scientists develop software tools for automated acquisition of electron microscopy data
SCIENCE & TECHNOLOGY2019
sciencescience-technology
The Arctic Ocean: reservoir of marine viruses
Results from the Tara Oceans expedition reveal the Arctic Ocean as a cradle of viral biodiversity
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Catalogue of structural variants
Thorough characterisation of structural variants in human genomes
SCIENCE & TECHNOLOGY2019
sciencescience-technology
ATP affects proteome-wide solubility
Scientists develop technology to measure how ATP concentration affects protein solubility in cells
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Many gut microbes may originate in the mouth
Many microbes traverse the oral-gut barrier
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Role reversal: RNA controls protein function
EMBL scientists identify RNA regulating protein behaviour in switch of normal roles
SCIENCE & TECHNOLOGY2019
sciencescience-technology
New method to study gene expression in yeast cells
Scientists develop high-throughput yeast single-cell RNA sequencing method
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Structure of prodrug-transporter complex revealed
Scientists develop structural model that could help in the development of drugs with increased absorption rates
SCIENCE & TECHNOLOGY2019
sciencescience-technology
New ways to look at protein-RNA networks
Researchers develop new method to analyse the entire protein-RNA network of the cell
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Time-resolved X-ray crystallography simplified
Speeding up time-resolved X-ray crystallography with EMBL beamline P14
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Transcription factors controlled by DNA sequence
EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Solving the structure of retromer
Retromer’s 3D structure improves understanding of cellular sorting and packaging
SCIENCE & TECHNOLOGY2018
sciencescience-technology
X-rays reveal surprising shape of scaffolding protein
X-ray experiments show that scaffolding protein PDZK1 has a L-shaped conformation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Cohesin: a glue for DNA
EMBL scientists discover how a component of the cohesin ring binds DNA
SCIENCE & TECHNOLOGY2018
sciencescience-technology
The proteins behind hungry cells
EMBL researchers visualise the proteins needed to capture molecules and bring them into a cell
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Algal nuclear pore complex revealed
EMBL scientists reveal NPC architecture of algae
SCIENCE & TECHNOLOGY2018
sciencescience-technology
New way to isolate DNA- and RNA-protein complexes
EMBL researchers develop method that simplifies the isolation of DNA- and RNA- protein complexes
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Reconstructing 3D shapes from unmeasurable data
Scientists at EMBL Hamburg determine shapes of intermediate states in dynamic biological systems
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Protein stability and solubility during cell cycle
EMBL scientists uncover large solubility and thermal stability changes of proteins during the cell cycle
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Counting condensins on chromosomes
EMBL scientists count and locate chromosomal proteins during cell duplication
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Insights into early cell life
New technique offers insight into early cell life
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Insights into the evolution of a signalling molecule
EMBL scientists discover how a molecule’s role changes from simple metabolite to instructive signal
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Your favourite reads of 2017
A look back at some of the most read stories on EMBL’s news website this year
LAB MATTERS2017
lab-matters
Research highlights
A summary of recent research highlights from EMBL
SCIENCE & TECHNOLOGY2017
sciencescience-technology
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