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Splicing twins: unravelling the secrets of the minor spliceosome complex
Researchers in the Galej Group at EMBL Grenoble have provided new insights into the structure of the minor spliceosome, an essential RNA-protein complex.
SCIENCE & TECHNOLOGY2025
science-technology
Structural insights reveal drug target in trypanosome parasites
The Kowalinski group at EMBL Grenoble identified significant differences between the trypanosomal and human nuclear cap-binding complex, a key player in cellular RNA metabolism and a potential target for novel anti-parasitic drugs.
SCIENCE & TECHNOLOGY2025
science-technology
We are EMBL: Romain Linares on the infinitely small and the infinitely large
Romain Linares talks about his role in managing the cryo-electron microscopy facility at EMBL Grenoble, how he sees this technique evolving in the coming years, and his passion for astronomy.
PEOPLE & PERSPECTIVES2024
people-perspectives
Building the cell’s splicing machine
New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.
SCIENCE & TECHNOLOGY2024
science-technology
Five takeaways from ‘Seeing is believing’ in 2023
A recent EMBO | EMBL symposium brought together leading developers of imaging methods with cutting-edge applications that illustrate how imaging can answer biological questions.
SCIENCE & TECHNOLOGY2023
eventsscience-technology
A glimpse into the hexasome: 40 years on
Research from the Eustermann group at EMBL Heidelberg reveals how the packaging of DNA into hexasomes impacts the function of enzymes involved in gene regulation.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
New EU-funded Project: Fragment-Screen
EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
LAB MATTERSSCIENCE & TECHNOLOGY2023
lab-mattersscience-technology
Solving the structure of a critical molecular editor
EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
SCIENCE & TECHNOLOGY2023
sciencescience-technology
Ardan Patwardhan and Wim Hagen receive Scientific Achievement Award
The Royal Microscopical Society awarded Ardan Patwardhan and Wim Hagen with Scientific Achievement Award
EMBL ANNOUNCEMENTSLAB MATTERS2022
embl-announcementslab-matters
Ardan Patwardhan receives Scientific Achievement Award
The Royal Microscopical Society recognises Ardan Patwardhan’s contributions to the field of electron microscopy.
2022
announcements
Shaping up the genome for cell division
Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Capturing ‘snapshots’ of a crucial step in RNA splicing
The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Solving molecular puzzles to find the perfect fit
Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
A gallery of human RNA polymerases
New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
EMBL Imaging Centre launches first open call for users
The new EMBL Imaging Centre has announced its first open user call, and new project evaluation process and training opportunities.
EMBL ANNOUNCEMENTSLAB MATTERS2021
embl-announcementslab-matters
Welcome: Svetlana Dodonova
Svetlana Dodonova is one of EMBL's newest group leaders, leading a team of researchers who will study how genetic material is organised inside cells using structural biology approaches.
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Cryo-Electron Microscopy Service Platform supports research on protein transport
Giulia Zanetti from the Institute of Structural and Molecular Biology (ISMB) in London explains how the collaboration with the Cryo-Electron Microscopy Service Platform enabled her group to reveal the structure of protein transport complexes.
LAB MATTERSSCIENCE & TECHNOLOGY2021
lab-mattersscience-technology
Structural biology reveals new opportunities to combat tuberculosis
EMBL Hamburg’s Wilmanns and Kosinski groups have determined the detailed structure of a bacterial protein complex critical for tuberculosis infection.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Matthew Hartley
The challenges and opportunities when setting up a global archive for bioimages
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Seeing through a cell
Liang Xue used cryo-electron tomography to capture this detailed image of a Mycoplasma pneumoniae cell.
SCIENCE & TECHNOLOGY2021
picture-of-the-weekscience-technology
At the core of the Integrator complex
A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
SCIENCE & TECHNOLOGY2021
sciencescience-technology
Welcome: Timo Zimmermann
The EMBL Imaging Centre is scheduled to open in 2021 with Timo Zimmermann as Team Leader for advanced light microscopy technology development and service provision.
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Welcome: Simone Mattei
The new team leader offering services in electron microscopy discusses his hopes and plans for the forthcoming EMBL Imaging Centre
LAB MATTERSPEOPLE & PERSPECTIVES2020
lab-matterspeople-perspectives
Flexible and protected – new findings on SARS-CoV-2 protein shed light on virus’s ability to infect cells
Researchers studied the spike protein on the surface of the SARS-CoV-2 virus. With its spikes, the virus binds to human cells and infects them. The study gave surprising insights into the spike protein, including an unexpected freedom of movement and a protective coat to hide it from antibodies.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding chromosome organisation
EMBL scientists and collaborators help reveal the process by which enormous quantities of DNA are folded into cells.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Investigating the structure and mechanisms of coronavirus biomolecules
While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding the influenza virus
The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Supporting international research on the structure of the coronavirus
EMBL Heidelberg reopens the Cryo-Electron Microscopy Service Platform to support coronavirus structural biology research.
CONNECTIONS2020
connectionsscience
Empowering European structural biology
EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology
EMBL ANNOUNCEMENTSLAB MATTERS2019
embl-announcementslab-matters
Photo-micropatterning advances structural cell biology
A new technique in cryo-EM
SCIENCE & TECHNOLOGY2019
sciencescience-technology
A tRNA modifier at work
Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Breaking the bottleneck in imaging data collection
Scientists develop software tools for automated acquisition of electron microscopy data
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Translating blue-sky research into the clinic
What does it take to create a vaccine or improve cancer therapies?
LAB MATTERSSCIENCE & TECHNOLOGY2018
lab-mattersscience-technology
More effective insulin thanks to first 3D image
New study reveals how to make therapeutic insulins more effective than they currently are
SCIENCE & TECHNOLOGY2018
sciencescience-technology
How cells export and embed proteins in the membrane
Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…
SCIENCE & TECHNOLOGY2010
sciencescience-technology