EMBL Grenoble showcased at Biophysical Society Meeting
Lab Matters EMBL’s French site was highlighted in a short film presenting its expertise in structural biology research and services.
2023
lab-matters
The retron switch
Science EMBL researchers now understand the function of an elusive small DNA in bacteria and have developed a tool that can be used to better understand what might ‘switch on’ bacterial immune defences.
2022
science
The new heroics of RNA in cell differentiation
Science EMBL research with Enolase 1 (ENO1) points to a possible new way to understand RNA’s leading role in how cells develop.
2022
science
Matthias Hentze receives Centenary Award
Lab Matters EMBL Heidelberg’s Matthias Hentze receives the Biochemical Society’s Centenary Award for his discoveries in RNA biology.
2022
lab-matters
Understanding genomes, piece by piece
Science Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.
2022
science
A gallery of human RNA polymerases
Science New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.
2021
science
How structural biology helps to make RNA vaccines
Science RNA vaccines, such as the ones for COVID-19, represent a new approach in vaccine technology. Cy Jeffries, faculty staff scientist at EMBL Hamburg, explains the clever technology behind RNA vaccines, and how structural biology contributes to its development. EMBL Hamburg collaborated on several…
2021
science
A model of cooperation for transporting mRNA
Science EMBL scientists generate a high-resolution crystal structure of the Kinesin-1/aTm1 transport complex in the fruit fly.
2021
science
Visualising RNA structures using R2DT
Science New software enables scientists to visualise RNA secondary structures using the world’s largest RNA structure dataset.
2021
science
Dream team
Picture of the week At EMBL, we have many dream teams – groups of individuals who support each other, innovate, and work together. One of those dream teams bridges two core facilities at EMBL Rome.
2021
picture-of-the-week
A better look at a human RNA polymerase
Science New EMBL research shows where & to what degree a component of cellular machinery known as RNA Pol III is mutated and becomes problematic.
2021
science
The central dogma of molecular biology
Picture of the week This colourful image shows biological information flow in action: It’s a supramolecular assembly of DNA, RNA and proteins, observed directly inside a bacterial cell while turning genetic information into protein.
2021
picture-of-the-week
Welcome: Olivier Duss
Lab Matters One of EMBL’s newest group leaders, Olivier Duss, will explore how RNA folds into functional structures and how it works with proteins to control a diverse range of activities in the cell.
2021
lab-matters
In kefir, microbial teamwork makes the dream work
Science Researchers discovered the dominant species of bacteria in kefir grains cannot endure without other species that help the 'team' survive.
2021
science
Tackling tropical diseases
Science Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness
2020
science
EMBL facilities support development of RNA vaccines
Science Biotechnology company BioNTech and Johannes Gutenberg University Mainz conduct collaborative research with EMBL scientists at the beamline P12 in Hamburg
2020
science
Investigating the structure and mechanisms of coronavirus biomolecules
Science While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
2020
science
Novel method sheds new light on tumour-suppressing RNA
Science Researchers from EMBL Grenoble have developed a way to visualise large RNAs in 3D using biochemical and structural biology techniques.
2020
science
Understanding the influenza virus
Science The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…
2020
science
Helping researchers identify host proteins used by coronavirus
Science EMBL scientists working in the groups of Matthias Hentze and Wolfgang Huber have created RBPbase – a database of RNA-binding proteins – to assist the identification of proteins that interact with the SARS-CoV-2 RNA genome.
2020
science
Characterising RNA alterations in cancer
Science The largest and most comprehensive catalogue of cancer-specific RNA alterations reveals new insights into the cancer genome.
2020
science
Lifetime Achievement Award for Matthias Hentze
Events EMBL Director honoured by the international RNA Society
2020
events
MEG3 kissing loops essential for tumour suppression
Science MEG3 adopts a complex three-dimensional structure to fulfil its tumour suppressor function.
2019
science
Role reversal: RNA controls protein function
Science EMBL scientists identify RNA regulating protein behaviour in switch of normal roles
2019
science
New ways to look at protein-RNA networks
Science Researchers develop new method to analyse the entire protein-RNA network of the cell
2018
science
Catching up on protein dynamics
Science The Hentze Lab enhanced a RNA-interactome capture technique to pave the way towards medical progress
2018
science
New way to isolate DNA- and RNA-protein complexes
Science EMBL researchers develop method that simplifies the isolation of DNA- and RNA- protein complexes
2018
science
Obituary: Elisa Izaurralde
Alumni Elisa Izaurralde, EMBL alumna, has passed away
2018
alumni
Loops in DNA affect which proteins are coded
Science EMBL scientists unveil how 3D chromatin structure affects RNA splicing
2017
science
Futures: Unravelling influenza
Science ERC grantee Stephen Cusack shares his vision for the next ten years
2017
science
Enzymes’ superimposable structures revealed
Science EMBL scientists superimpose structures of two-metal-ion enzymes and reveal new potential drug targets
2017
science
Discovering protein smartphones
Science New technique reveals uncharted docking sites in RNA-binding proteins
2016
science
DNA protection, inch by inch
Science European team identify mechanism for producing piRNAs that silence jumping genes in germline cells.
2015
science
RNAcentral Station
Science RNAcentral is the first unified resource for all types of non-coding RNA data.
2014
science
Clarity in the cold
Science How fruit flies beat the cold, plus the value of precisely controlled experiments and detailed analysis
2014
science
Nothing but blue skies
Science Focusing on basic research is crucial for the development of more advanced genetics techniques
2014
science
Bigger, better, faster
Science The molecular machine that makes essential components of ribosomes – the cell’s protein factories – is like a Swiss-army knife, researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and the Centro de Investigaciones Biológicas in Madrid, Spain, have found.…
2013
science
Choreographed origami
Science An important step in building ribosomes – the cell’s protein factories – is like a strictly choreographed dance, scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered. To build these factories, other ‘machines’ inside the cell have to…
2013
science
Pushing the boundaries of transcription
Science Like musicians in an orchestra who have the same musical score but start and finish playing at different intervals, cells with the same genes start and finish transcribing them at different points in the genome. For the first time, researchers at EMBL have described the striking diversity of…
2013
science
Zeroing in on heart disease
Science Studies screening the genome of hundreds of thousands of individuals (known as Genome-wide association studies or GWAS) have linked more than 100 regions in the genome to the risk of developing cardiovascular disease. Researchers from the European Molecular Biology Laboratory (EMBL) and the…
2013
science
Protein production: going viral
Science A research team of scientists from EMBL Grenoble and the IGBMC in Strasbourg, France, have, for the first time, described in molecular detail the architecture of the central scaffold of TFIID: the human protein complex essential for transcription from DNA to mRNA. The study, published today…
2013
science
The cell’s ‘New World’
Science In one of the most famous faux pas of exploration, Columbus set sail for India and instead ‘discovered’ America. Similarly, when scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, set out to find enzymes – the proteins that carry out chemical…
2012
science
New findings reveal how influenza virus hijacks human cells
Science Influenza is and remains a disease to reckon with. Seasonal epidemics around the world kill several hundred thousand people every year. In the light of looming pandemics if bird flu strains develop the ability to infect humans easily, new drugs and vaccines are desperately sought. Researchers at…
2009
science
An ambulance man for muscle damage
Science It does not take much to injure a muscle. Sometimes one sudden, inconsiderate movement does the job. Unfortunately, damaged muscles are not as efficient at repair as other tissues such as bone. Researchers of the European Molecular Biology Laboratory’s Mouse Biology Unit (EMBL), Italy, and…
2007
science
A switch between life and death
Science Cells in an embryo divide at an amazing rate to build a whole body, but this growth needs to be controlled. Otherwise the result may be defects in embryonic development or cancer in adults. Controlling growth requires that some cells divide while others die; their fates are determined by signals…
2006
science
Defusing dangerous mutations
Science Mutations in genes are the basis of evolution, so we owe our existence to them. Most mutations are harmful, however, because they cause cells to build defective proteins. So cells have evolved quality control mechanisms that recognize and counteract genetic mistakes. Now scientists of the Molecular…
2005
science
Public collections of DNA and RNA sequence reach 100 gigabases
Lab Matters The world’s three leading public repositories for DNA and RNA sequence information have reached 100 gigabases (100,000,000,000 bases; the ‘letters’ of the genetic code) of sequence. Thanks to their data exchange policy, which has paved the way for the global exchange of many types…
2005
lab-matters
Hunt for human genes involved in cell division under way
Lab Matters A systematic search through human genes has begun at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany. Working within the MitoCheck consortium that includes 10 other institutes throughout Europe, the EMBL scientists will silence all human genes, one-by-one, to find those…
2005
lab-matters
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