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infection biology

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20 December 2022

First linked dataset on Pathogens Portal

Updates from data resources The first  cohort study linking data across categories was recently added on the Pathogens Portal Cohort Browser and is also accessible from the BioSamples browser. This pilot study comes from Erasmus Medical Centre through the ReCoDID project, one of the COVID-19 Data Platform supporting…

2022

updates-from-data-resources

1 December 2022

Getting closer to stopping toxoplasmosis infection

Science Recent studies supported by EMBL Grenoble’s expertise in structural biology research and scientific services have identified Altiratinib as a potential drug to stop toxoplasmosis infection and opened up treatment options against malaria.

2022

science

7 June 2022 Female scientist photographed in a garden

Welcome: Pascale Cossart

Lab Matters Pascale Cossart, one of the world’s foremost authorities on the biology of Listeria, brings four decades of expertise in intracellular bacterial parasitism to EMBL as a visiting scientist.

2022

lab-matters

22 December 2021 Scientific illustrations of MEG3, a very large RNA involved in cell proliferation. IAB and EMBL logos are located in the center of the illustration.

EMBL-IAB collaboration on the rise

Lab Matters The memorandum of understanding (MoU) signed between EMBL and the Institute for Advanced Biosciences (IAB) a year ago has already catalysed new grants for joint research projects related to cancer and infection biology, thereby deepening collaborative activities.

2021

lab-matters

20 December 2021 A detailed structure map shows two proteins interacting in the foreground, each shown in a different colour. The background shows small green dots marking bacteria

Solving molecular puzzles to find the perfect fit

Science Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.

2021

science

15 October 2021 In the middle, there are two molecules of pUL21. One is blurred, to represent the molecule’s flexibility. In the background are two neuronal scenes. The one on the left is healthy and has a smooth surface. The one on the right is infected, which is represented by several green viral particles.

How herpes seizes proteins’ means of production

Science The Graham and Crump groups at the University of Cambridge and the Svergun Group at EMBL Hamburg have discovered a mechanism by which the herpes simplex virus takes control of the molecular machinery of human cells. Their work reveals how a dedicated viral protein hijacks key host proteins, forcing…

2021

science

7 October 2021 SARS-CoV-2 and planet Earth are merged together in this illustration

Six Ways to Protect the Planet Against Pandemics*

Events EMBL will host a conference to look at the state of the pandemic, lessons learned, and ways to improve pandemic preparedness. Here’s a sneak peek into what promises to be another interesting and informative EMBL conference.

2021

events

22 September 2021 Logos of EMBL and Helmholtz Association on white background, over a green-and-blue pattern in the background.

EMBL and Helmholtz Health join forces

Lab Matters EMBL and Helmholtz Association have signed a memorandum of understanding. The expanded collaboration of both institutions will focus on research related to health.

2021

lab-matters

25 May 2021 Microscope image of an engineered human blood vessel, featuring individual cells outlined in pink with blue nuclei.

Barriers against malaria

Picture of the week The Bernabeu Group aims to increase our knowledge of cerebral malaria, using in vitro engineered networks of human blood vessels and brain cells.

2021

picture-of-the-week

21 May 2021 Image of a mosquito on a clear surface

EMBL scientists support malaria research

Science EMBL scientists support research on malaria by providing freely available data resources and using innovative experimental approaches. Our Course and Conference Office facilitates the exchange of knowledge in the field by hosting the annual BioMalPar conference.

2021

science

2 December 2020 Curly-shaped trypanosomes, grey with bright specks of green fluorescent protein, against a grey background.

Tackling tropical diseases

Science Members of the EMBL community are working to improve our understanding of the parasites that cause malaria and sleeping sickness

2020

science

13 October 2020 Molecular structure of essential light chain protein in Plasmodium glideosome. The atoms connected by bonds are symbolised by short connected lines. They are surrounded by electrons – the electron density is depicted as shapes resembling clouds. Water molecules are visible in several places as red spots. The data used to create this 3D model were obtained using X-ray crystallography at Petra III beamline, at EMBL Hamburg.

How deadly parasites ‘glide’ into human cells

Science A group of scientists led by EMBL Hamburg’s Christian Löw provide insights into the molecular structure of proteins involved in the gliding movements through which the parasites causing malaria and toxoplasmosis invade human cells.

2020

science

8 July 2020 Artwort illustrating various aspects of infection research. The centre of the image shows a cartoon representation of a coronavirus. The spheric shape has been overlaid with a map of the world to illustrate the global spread of viruses. The edges of the artwork feature images of potential virus hosts (bats, poultry, dromedary), a group of humans, a microscope, pills, a syringe and vaccine vial, protein structures, and an illustration of a human lung. The background is set in yellow and red colour.

What COVID-19 is teaching us

Events The virtual EMBL Conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future.

2020

events

17 June 2020 Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

Science While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

2020

science

15 June 2020 Key visual for the virtual EMBL conference ‘SARS-CoV-2: Towards a New Era in Infection Research’. Credits: Aleksandra Krolik/EMBL

Improving our response to emerging pandemics

Events The emergence of previously unknown pathogens, such as the novel coronavirus SARS-CoV-2, raises many questions. To explore these questions in an international scientific forum, EMBL will host the virtual conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ on 3 July. Invited…

2020

events

27 May 2020 Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

Science EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

2020

science

29 April 2020 The Influenza virus

Understanding the influenza virus

Science The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…

2020

science

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