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Gene expression

An embryo of the fruit fly Drosophila.

Predicting how gene expression varies

Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical…

By Fabian Oswald

Science
The image shows a larva of Platynereis dumerilii, a marine worm. The body of the worm is shown in grey. Muscle strands are coloured in red. The muscles of one individual strand are highlighted in different, brighter colours.

Muscular worm larva

The image shows a larva of Platynereis dumerilii, a marine worm. The image here was produced by Constantin Pape, a visiting predoctoral fellow in the…

By Mathias Jäger

Picture of the week
An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of…

By Marius Bruer

Science
3D reconstruction of parental chromosomes in the mouse embryo

How chromosome structure influences development

EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early…

By Fabian Oswald

Science
oscillations of gene activity

Tissue dynamics provide clues to human disease

EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and…

By Guest author(s)

Science

New insights into gene regulation

EMBL researchers investigate the role of a histone protein in regulating gene…

By Chloe Cross

Science
Stripes of colour display gene expression patterns

Transcriptional hubs confer phenotypic robustness

Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful…

By Josh Tapley

Science
The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene…

By Iris Kruijen

Science
In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

The scientific origins of Edith Heard

EMBL’s next Director General reflects on the questions that drive her…

By Guest author(s)

Science
Arnaud Krebs, EMBL’s new group leader studies how gene expression is controlled

Welcome: Arnaud Krebs

EMBL’s new group leader studies how gene expression is…

By Berta Carreño

Science
Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

EMBL scientists show that some promoters can act as enhancers and vice…

By Iris Kruijen

Science
high-resolution nucleosome structure

Solving the nucleosome: twenty years on

Tim Richmond looks back on the work that revealed the high-resolution structure of the…

By Edward Dadswell

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