Gene expression
Enabling functional genomics studies in individual cells
Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
How chromosome structure influences development
EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo…
Tissue dynamics provide clues to human disease
EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and ribs…
New insights into gene regulation
EMBL researchers investigate the role of a histone protein in regulating gene expression…
Transcriptional hubs confer phenotypic robustness
Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions…
Rearranging chromosomes
Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.…
The scientific origins of Edith Heard
EMBL’s next Director General reflects on the questions that drive her research…
Welcome: Arnaud Krebs
EMBL’s new group leader studies how gene expression is controlled…
Multipurpose enhancers and promoters in embryonic development
EMBL scientists show that some promoters can act as enhancers and vice versa…
Solving the nucleosome: twenty years on
Tim Richmond looks back on the work that revealed the high-resolution structure of the nucleosome…
