gene expression Archives

11 December 2024

Welcome: Christina Ernst

People & Perspectives EMBL-EBI's new Functional Genomics Team Leader will develop standards for new data types and integrate AI into workflows.

2024

people-perspectivesperspectives

29 November 2024 The sea anemone is visible as an elongated shape against a dark background, with gene expression visible in four colours (green – concentrated in the tentacles to the right, orange – at the base of the tentacles, yellow – in a leaf shape near the middle, purple – concentrated in the end opposite the tentacles, to the left)

The sea anemone is visible as an elongated shape against a dark background, with gene expression visible in four colours (green – concentrated in the tentacles to the right, orange – at the base of the tentacles, yellow – in a leaf shape near the middle, purple – concentrated in the end opposite the tentacles, to the left)

Sea anemone study shows how animals stay ‘in shape’

Science & Technology Scientists have shown how regenerating sea anemones restore their shape following a major injury, uncovering novel cellular and molecular mechanisms.

2024

science-technology

24 September 2024 Single Cell Expression Atlas logo on green background

Single Cell Expression Atlas 21 released

New datasets The release has 381 single-cell RNA-Seq experiments, consisting of more than 13.5 million cells from 21 different species to explore in the Single Cell Expression Atlas (SCEA). The resource now includes an entirely new class of data – externally analysed data, marked with an…

2024

updates-from-data-resources

4 September 2024

Alvis Brazma: What I’ve learned

People & Perspectives EMBL-EBI alumnus Alvis Brazma reflects on how mathematics and mountaineering have shaped his life and why keeping things simple in bioinformatics is key.

2024

people-perspectivesperspectives

2 July 2024

IIT-EMBL: New molecules to modulate gene expression

Science & Technology A new research paper published in Nature Communications lays the groundwork for the development of new drugs specific to genetic mutations or alterations responsible for the onset of tumours or genetic diseases.

2024

science-technology

17 May 2024 Expression Atlas logo

Expression Atlas 40 released

The latest Expression Atlas 40 release is now live, containing new RNA-seq datasets, including a featured experiment resulting from a collaboration with Genotype Tissue Expression (GTEx) project as well as new proteomics data derived from our collaboration with PRIDE. In total, this release…

2024

updates-from-data-resources

4 April 2024

Building the cell’s splicing machine

Science & Technology New study from the Galej group provides deeper structural insight into the assembly of a critical molecular machine, that removes non-coding information from genes during their expression.

2024

science-technology

11 March 2024

Casting new light on gene regulation in development

Science & Technology New research from EMBL Heidelberg shows how cells in developing embryos undergo a major shift in the way they regulate gene expression as they mature and differentiate.

2024

sciencescience-technology

23 November 2023 Photographs of two scientists on a decorative background

ERC Consolidator Grants awarded to two EMBL researchers

EMBL AnnouncementsLab Matters Alba Diz-Muñoz and Arnaud Krebs from EMBL Heidelberg have received grants to work on projects that aim, respectively, to understand the cellular mechanics that control cell division and investigate the regulatory networks that govern transcription factor function.

2023

embl-announcementslab-matters

24 July 2023 A stylised heart rhythm created using a DNA strand is superimposed on the image of a human heart. Two inset images show an artistic illustration of gene editing and a fluorescent microscopy image of cardiomyocytes, respectively.

A stylised heart rhythm created using a DNA strand is superimposed on the image of a human heart. Two inset images show an artistic illustration of gene editing and a fluorescent microscopy image of cardiomyocytes, respectively.

New therapies to improve cardiovascular health

Science & Technology EMBL researchers have made new strides into understanding and reversing genetic defects that underlie familial heart disease.

2023

sciencescience-technology

20 July 2023 Expression Atlas logo

Latest release of the Expression Atlas

The latest Expression Atlas release is now live and contains a wider range of RNA-seq and proteomics datasets.

2023

updates-from-data-resources

14 July 2023 A close-up of the flow chamber of an ICS machine, with a scientist’s hand in the foreground.

The power of cell sorting: understanding heart disease, phase separation, plankton, and more

Science & Technology EMBL researchers use a new cell sorting technology to gain new insights into cellular function in health and disease, as well as for other innovative applications.

2023

sciencescience-technology

2 June 2023

ProtVar: understanding missense variation in humans

Science & Technology A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.

2023

sciencescience-technologytechnology-and-innovation

7 February 2023

Solving the structure of a critical molecular editor

EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.

2023

science

19 October 2022 ArrayExpress logo; a red A and green E in a circle with the word ArrayExpress

ArrayExpress interface now retired

Data continues to be available in BioStudies.

2022

updates-from-data-resources

4 August 2022 An illustration provides representation of fingers hovering over a cell phone

Zooming in to get the full picture

Science & Technology EMBL and UW researchers plus additional collaborators have constructed a complete map of fruit fly embryonic development using machine learning. This research is foundational to better understanding overall embryo development in other species, including humans.

2022

sciencescience-technology

4 March 2022 Science art expressing the concept of transcriptional neighbourhoods regulating transcript isoform lengths and expression levels.

Science art expressing the concept of transcriptional neighbourhoods regulating transcript isoform lengths and expression levels.

Understanding genomes, piece by piece

Science & Technology Genomes are made up of thousands of individual pieces – genes – which are expressed at different levels. Researchers at EMBL have shed light on how the placement of a gene affects its expression, as well as that of its neighbours.

2022

sciencescience-technology

25 February 2022 Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Three colourful overlapping circles arranged in a row, a fruit-fly embryo being visible within each. Small circles within the embryos represent cell lineages.

Converging lenses on embryo development

Science & Technology Researchers from the Furlong group at EMBL have come up with a way to observe the development of fruit-fly embryos simultaneously at the genetic and cellular levels, generating a high-resolution and integrated view of how different cell lineages form.

2022

sciencescience-technology

24 February 2022 Expression Atlas database logo - A magnifying glass highlighting a yellow section on a blue background

New Expression Atlas release in collaboration with PRIDE

New Expression Atlas release features differential-proteomics and baseline-proteomics experiments in collaboration with the PRIDE team at EMBL-EBI. This also includes new baseline DIA proteomics experiments as well as new differential proteomics datasets. To improve reproducibility,…

2022

updates-from-data-resources

21 January 2022 The cross-section of a cell expressing a green fluorescently tagged protein and illuminated by a blue laser is visible in the foreground, surrounded by a vortex of cells

The cross-section of a cell expressing a green fluorescently tagged protein and illuminated by a blue laser is visible in the foreground, surrounded by a vortex of cells

Cell sorting enters a new dimension

Science & Technology EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.

2022

sciencescience-technology

18 January 2022 Science illustration composed by a photographic film highlighting three-dimensional structures of a protein complex involved in splicing.

Science illustration composed by a photographic film highlighting three-dimensional structures of a protein complex involved in splicing.

Capturing ‘snapshots’ of a crucial step in RNA splicing

Science & Technology The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.

2022

sciencescience-technology

16 November 2021 Collage showing different species that play an essential part in global food security, including cattle, pollinators and plants

Collage showing different species that play an essential part in global food security, including cattle, pollinators and plants

Can data help feed a hungry world?

Science & Technology How genomics, open data, and multidisciplinary science can improve food security.

2021

sciencescience-technology

5 October 2021 Illustration of a globe with colourful shapes and symbols superimposed.

A cellular atlas of an entire worm

Science & Technology EMBL scientists and colleagues have developed an interactive atlas of the entire marine worm Platynereis dumerilii in its larval stage. The PlatyBrowser resource combines high-resolution gene expression data with volume electron microscopy images.

2021

sciencescience-technology

4 March 2021

Induced pluripotent stem cells reveal causes of disease

Science & Technology Scientists in the Stegle group and colleagues have studied induced pluripotent stem cells from around 1,000 donors to identify correlations between individual genetic variants and altered gene expression. They linked more than 4,000 of the genetic variants responsible for altered expression…

2021

sciencescience-technology

5 February 2021 Artistic representation of the structure of the three proteins forming Integrator’s catalytic core.

At the core of the Integrator complex

Science & Technology A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.

2021

sciencescience-technology

19 August 2020 An embryo of the fruit fly Drosophila.

Predicting how gene expression varies

Science & Technology Discoveries at EMBL will help researchers to interpret one of the most common types of experiments in genomics and medical studies.

2020

sciencescience-technology

14 July 2020

The image shows a larva of Platynereis dumerilii, a marine worm. The body of the worm is shown in grey. Muscle strands are coloured in red. The muscles of one individual strand are highlighted in different, brighter colours.

Muscular worm larva

Science & Technology The image shows a larva of Platynereis dumerilii, a marine worm. The image here was produced by Constantin Pape, a visiting predoctoral fellow in the Kreshuk group at EMBL Heidelberg.

2020

picture-of-the-weekscience-technology

1 June 2020 An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Science & Technology Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

2020

sciencescience-technology

9 April 2020 3D reconstruction of parental chromosomes in the mouse embryo

How chromosome structure influences development

Science & Technology EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo

2020

sciencescience-technology

3 April 2020 oscillations of gene activity

Tissue dynamics provide clues to human disease

Science & Technology EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and ribs

2020

sciencescience-technology

5 March 2020

New insights into gene regulation

Science & Technology EMBL researchers investigate the role of a histone protein in regulating gene expression

2020

sciencescience-technology

24 July 2019 Stripes of colour display gene expression patterns

Transcriptional hubs confer phenotypic robustness

Science & Technology Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions

2019

sciencescience-technology

15 July 2019

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Science & Technology Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

2019

sciencescience-technology

28 May 2018 In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

The scientific origins of Edith Heard

People & Perspectives EMBL’s next Director General reflects on the questions that drive her research

2018

people-perspectivesscience

9 February 2018 Arnaud Krebs, EMBL’s new group leader studies how gene expression is controlled

Welcome: Arnaud Krebs

People & Perspectives EMBL’s new group leader studies how gene expression is controlled

2018

people-perspectivesscience

30 January 2018 Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

Science & Technology EMBL scientists show that some promoters can act as enhancers and vice versa

2018

sciencescience-technology

29 June 2017 high-resolution nucleosome structure

Solving the nucleosome: twenty years on

Science & Technology Tim Richmond looks back on the work that revealed the high-resolution structure of the nucleosome

2017

eventsscience-technology

9 June 2017

Mapping gene expression, cell by cell

Science & Technology EMBL researchers complete a molecular atlas showing gene expression in all cells in an entire animal

2017

sciencescience-technology

6 June 2017

Senses: Silencing noise

Science & Technology Two EMBL researchers are exploring new ways to filter out noise and get to the data they need

2017

sciencescience-technology

13 March 2017

Futures: Genome regulation

Science & Technology ERC grantee Eileen Furlong shares her vision for the next ten years

2017

sciencescience-technology

26 January 2017 Illustration of two mice with different sleeping preferences.

Genetics of ‘room-mate’ influences health

Science & Technology Healing and anxiety are influenced by the genetics of one’s social partners

2017

sciencescience-technology

25 January 2017 Wojciech Galej, new group leader at EMBL

Welcome: Wojciech Galej

People & Perspectives New group leader Wojciech Galej investigates RNA-protein complexes involved in gene expression

2017

people-perspectivesscience

24 November 2016

Chromatin cartographer

People & Perspectives EMBL alumnus Jop Kind reflects on the questions that led him to this year’s John Kendrew Award

2016

alumnipeople-perspectives

9 November 2015 Bertone and Smith: Unpacking embryonic pluripotency

Unpacking embryonic pluripotency

Science & Technology Embryology, genomics and bioinformatics combine to identify factors regulating mammalian pluripotency.

2015

sciencescience-technology

14 October 2015 single-cell transcriptomics reveals biologically relevant heterogeneity in expression

A snapshot of stem cell expression

Science & Technology Study of mouse embryonic stem cells reveals new genes involved in the stem-cell regulatory network.

2015

sciencescience-technology

14 April 2015 Nature Biotechnology, DOI: 10.1038/nbt.3209

Towards an expression atlas for an entire brain

Science & Technology New single-cell genomics techniques bring ‘omics to evolution and development research.

2015

sciencescience-technology

8 January 2012 Diagram of chromatin enhancers

Tracking genes’ remote controls

Science & Technology As an embryo develops, different genes are turned on in different cells, to form muscles, neurons and other bodily parts. Inside each cell’s nucleus, genetic sequences known as enhancers act like remote controls, switching genes on and off. Scientists at the European Molecular Biology Laboratory…

2012

sciencescience-technology

4 November 2009 fluorescence microscopy images of fruit fly embryos

Deciphering the regulatory code

Science & Technology Embryonic development is like a well-organised building project, with the embryo’s DNA serving as the blueprint from which all construction details are derived. Cells carry out different functions according to a developmental plan, by expressing, i.e. turning on, different combinations of genes.…

2009

sciencescience-technology

28 May 2009

Sugarcoating fruit fly development

Science & Technology Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…

2009

sciencescience-technology

6 March 2008

New revelations in epigenetic control shed light on breast cancer

Science & Technology Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…

2008

sciencescience-technology

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EMBLetc.

Issue 101 Winter 2023

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