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Gene expression

An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

By Marius Bruer

Science

3D reconstruction of parental chromosomes in the mouse embryo

How chromosome structure influences development

EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early embryo…

By Fabian Oswald

Science

oscillations of gene activity

Tissue dynamics provide clues to human disease

EMBL scientists examine the molecular causes of a rare hereditary disease of the spine and ribs…

By Guest author(s)

Science

New insights into gene regulation

EMBL researchers investigate the role of a histone protein in regulating gene expression…

By Chloe Cross

Science

Stripes of colour display gene expression patterns

Transcriptional hubs confer phenotypic robustness

Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions…

By Josh Tapley

Science

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.…

By Iris Kruijen

Science

In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

The scientific origins of Edith Heard

EMBL’s next Director General reflects on the questions that drive her research…

By Guest author(s)

Science

Arnaud Krebs, EMBL’s new group leader studies how gene expression is controlled

Welcome: Arnaud Krebs

EMBL’s new group leader studies how gene expression is controlled…

By Berta Carreño

Science

Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

EMBL scientists show that some promoters can act as enhancers and vice versa…

By Iris Kruijen

Science

high-resolution nucleosome structure

Solving the nucleosome: twenty years on

Tim Richmond looks back on the work that revealed the high-resolution structure of the nucleosome…

By Edward Dadswell

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