Iris Kruijen, Author at EMBL

19 December 2019 Before a biological sample reaches the beamline, a lot of work is put into its preparation. Scientists can use the wide range of services and resources at EMBL to prepare their biological samples for structural studies at the X-ray beamlines in Grenoble and Hamburg. Photo: Marietta Schupp/EMBL

Before a biological sample reaches the beamline, a lot of work is put into its preparation. Scientists can use the wide range of services and resources at EMBL to prepare their biological samples for structural studies at the X-ray beamlines in Grenoble and Hamburg. Photo: Marietta Schupp/EMBL

Empowering European structural biology

Lab Matters EU funding for iNEXT-Discovery consortium unlocks key technologies for structural biology

2019

lab-matters

13 December 2019

Graduation Ceremony 2019

Lab Matters Forty-seven PhD students from all of EMBL’s six sites were celebrated during EMBL’s 2019 Graduation Ceremony on Friday 13 December

2019

lab-matters

23 July 2019 EMBL appoints new Directors and Associate Directors

New Directors and Associate Directors

Lab Matters Promotions for Anne Ephrussi, Rainer Pepperkok, Paul Flicek and Jo McEntyre

2019

lab-matters

15 July 2019

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Science Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.

2019

science

21 June 2019 Tara in the harbour in Hamburg.

EMBL joins Tara stopovers in London and Hamburg

Events Tara schooner welcomes on board journalists, policymakers, funders and scientists

2019

events

16 May 2019 map of tara stops near EMBL sites

The origins of plastic pollution at sea

Science Tara Ocean Foundation launches the exploration of 10 European rivers

2019

science

1 April 2019

Global microbial signatures for colorectal cancer

Science Colorectal cancer characterised by consistent changes in gut bacteria across continents, cultures and diets

2019

science

28 March 2019 Sketch of a building being constructed in a city landscape

Designer organelles bring new functionalities into cells

Science EMBL scientists create membraneless organelle to build proteins in living cell

2019

science

18 February 2019 Toxin-Antitoxin system in tuberculosis

Cell death trigger in tuberculosis bacteria

Science Suicide system in tuberculosis bacteria might hold key to treatment

2019

science

19 December 2018 The robots used during the experiments. The shape of this particular swarm is a hand-made illustration of the technique. PHOTO: reprinted with permission from AAAS

The robots used during the experiments. The shape of this particular swarm is a hand-made illustration of the technique. PHOTO: reprinted with permission from AAAS

Hundreds of tiny robots grow bio-inspired shapes

Science Scientists build self-organising features into robot swarms to study shape formation

2018

science

17 December 2018 Mouse skin samples of the rare genetic skin disease amyloidosis, before light treatment (left) and after treatment (right). The arrows indicate aggregates of debris, which cause the skin to become rough and uncomfortable. Upon treatment these aggregates are reduced, allowing the skin to heal. IMAGES: Paul Heppenstall and Linda Nocchi / EMBL

Mouse skin samples of the rare genetic skin disease amyloidosis, before light treatment (left) and after treatment (right). The arrows indicate aggregates of debris, which cause the skin to become rough and uncomfortable. Upon treatment these aggregates are reduced, allowing the skin to heal. IMAGES: Paul Heppenstall and Linda Nocchi / EMBL

Using light to stop itch

Science EMBL researchers have found a way to stop itch with light in mice

2018

science

24 October 2018 Insulin receptor structural biology. IMAGE: Felix Weis and Christoph Müller / EMBL

More effective insulin thanks to first 3D image

Science New study reveals how to make therapeutic insulins more effective than they currently are

2018

science

1 October 2018 Studying the molecular features of ageing in human blood stem cells showed that as blood stem cells age, their sugar metabolism increases. IMAGE: Campbell Medical Illustration

Studying the molecular features of ageing in human blood stem cells showed that as blood stem cells age, their sugar metabolism increases. IMAGE: Campbell Medical Illustration

Ageing is visible in the way cells use glucose

Science Researchers from EMBL and Heidelberg University unveil the molecular mechanisms of ageing

2018

science

13 September 2018 IMAGE: Manon Boschard

X-rays reveal surprising shape of scaffolding protein

Science X-ray experiments show that scaffolding protein PDZK1 has a L-shaped conformation

2018

science

10 September 2018 A dynamic protein atlas of a human cell. IMAGE: Aleksandra Krolik/EMBL

First interactive model of human cell division

Science Real-time tracking of proteins during mitosis is now possible using a 4D computer model

2018

science

1 August 2018 Global warfare between bacteria and fungi in soil. IMAGE: Hildebrand/Krolik in collaboration with Campbell Medical Illustration/EMBL

Global warfare between bacteria and fungi in soil. IMAGE: Hildebrand/Krolik in collaboration with Campbell Medical Illustration/EMBL

Understanding soil through its microbiome

Science First global survey of soil genomics reveals a war between fungi and bacteria

2018

science

12 July 2018 Artistic 3D rendering of the dual spindle in the mammalian zygote. IMAGE: Cartasiova, Hossain, Reichmann, Ellenberg/EMBL

Parental chromosomes kept apart during first division

Science Mammalian life begins differently than we thought

2018

science

11 July 2018 IMAGE: Aleksandra Krolik, EMBL

Maternal bacteria persistent in newborns

Science Scientists show how bacteria and other microorganisms are passed on from mother to child

2018

science

6 July 2018 E. coli bacteria colored in heat gradient. IMAGE: Aleksandra Krolik / EMBL

Melting bacteria to decipher antibiotic resistance

Science EMBL scientists investigate how bacteria melt to study their reaction to drugs

2018

science

26 June 2018 Mutations at the amino acid shown in orange (isoleucine 38) lead to reduced susceptibility to the drug. IMAGE - Stephen Cusack, EMBL

Flu’s response to new drug explored

Science EMBL scientists investigate how influenza virus responds to new drug treatment

2018

science

18 June 2018 Three examples of the tissue shapes the team created. The black and white square, circle and triangle on the left correspond to the cells that were illuminated. On the right, three fruit fly embryos are shown in cyan, magenta and yellow, demonstrating how the illuminated cells folded inwards after the light-activation. IMAGE: Stefano De Renzis, EMBL

Three examples of the tissue shapes the team created. The black and white square, circle and triangle on the left correspond to the cells that were illuminated. On the right, three fruit fly embryos are shown in cyan, magenta and yellow, demonstrating how the illuminated cells folded inwards after the light-activation. IMAGE: Stefano De Renzis, EMBL

Constructing new tissue shapes with light

Science EMBL researchers guide the shape of cells and tissues with optogenetics

2018

science

29 May 2018 Intermediate detection in capsid formation of the lumazine synthase enzyme. CREDIT: Aleksandra Krolik / EMBL

Reconstructing 3D shapes from unmeasurable data

Science Scientists at EMBL Hamburg determine shapes of intermediate states in dynamic biological systems

2018

science

10 May 2018 MRI image of a medulloblastoma

New risk factors for rare childhood cancer

Science Researchers identify genes that can cause brain tumours in children and other cancers later in life

2018

science

7 May 2018

New Platform Transforms CRISPR Gene Editor Into Precision Tool. IMAGE: Irvine/NIST

CRISPR: from clipping scissors to word processor

Science New platform transforms CRISPR gene editor into precision tool

2018

science

26 April 2018 Dividing cell colored in a heat gradient, highlighting the variation in proteins’ thermal stability within and between different cell cycle stages. IMAGE: Aleksandra Krolik / EMBL

Dividing cell colored in a heat gradient, highlighting the variation in proteins’ thermal stability within and between different cell cycle stages. IMAGE: Aleksandra Krolik / EMBL

Protein stability and solubility during cell cycle

Science EMBL scientists uncover large solubility and thermal stability changes of proteins during the cell cycle

2018

science

24 April 2018

Managing chronic pain with light

Science Scientists at EMBL Rome develop new method that uses light to manage neuropathic pain in mice

2018

science

19 April 2018

Dog microbiome closer to humans’ than expected

Science Dog and human gut microbiomes have more similar genes and responses to diet than previously thought

2018

science

26 March 2018 Multiple synapse heads send out filopodia (green) converging on one microglia (red), as seen by focused ion beam scanning electron microscopy (FIBSEM).

Multiple synapse heads send out filopodia (green) converging on one microglia (red), as seen by focused ion beam scanning electron microscopy (FIBSEM).

Captured: microglia nibbling on brain synapses

Science For the first time, EMBL Rome researchers have captured microglia nibbling on brain synapses on film.

2018

science

19 March 2018

Commonly used drugs affect our gut bacteria

Science One in four drugs with human targets inhibit the growth of bacteria in the human gut, and may promote antibiotic resistance, EMBL researchers report in Nature

2018

science

19 March 2018

Molecular cuisine for gut bacteria

Science EMBL scientists show how to grow a wide range of gut bacteria in the lab

2018

science

15 March 2018 Potential new way to limit antibiotic resistance spreading. IMAGE: Aleksandra Krolik / EMBL

Potential way to limit antibiotic resistance

Science EMBL scientists unravel the molecular basis of a major antibiotic resistance transfer mechanism

2018

science

15 March 2018

How drugs affect the life and death of proteins

Science Scientists at EMBL and Cellzome develop technology to monitor the effects of drug treatments on protein degradation and synthesis

2018

science

14 March 2018 Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

Science EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories

2018

science

7 March 2018 EMBL spinoff Velabs Therapeutics to help antibody discovery. IMAGE: Velabs Therapeutics

EMBL spinoff to help antibody discovery

Lab Matters New EMBL spinoff company Velabs Therapeutics aims to speed up discovery of therapeutic antibodies

2018

lab-matters

22 February 2018 A condensin protein complex creates a loop in DNA. IMAGE: Cees Dekker Lab TU Delft/Scixel

Loops, loops and loops: how DNA gets organised

Science Researchers from Delft University and EMBL crack the mystery of condensin’s neat DNA loop extrusion

2018

science

22 February 2018

Synchronised waves control embryonic patterning

Science EMBL scientists show that the rhythm between Wnt and Notch waves enables patterning in embryos.

2018

science

30 January 2018 Enhancer activity (green) and promoter activity (purple) in the same regulatory element. IMAGE: EMBL / Eileen Furlong

Multipurpose enhancers and promoters in embryonic development

Science EMBL scientists show that some promoters can act as enhancers and vice versa

2018

science

21 December 2017 The colour of the dots on this ATM keypad represents the amount of a molecule that was transferred from the person’s finger to the keypad.