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SARS-CoV-2

Illustration showing globe, statistics and viruses

Funding to predict the risk of infectious disease outbreaks

European collaboration receives funding to explore risks and impact of future infectious disease outbreaks.

By Oana Stroe

Lab Matters

Artwort illustrating various aspects of infection research. The centre of the image shows a cartoon representation of a coronavirus. The spheric shape has been overlaid with a map of the world to illustrate the global spread of viruses. The edges of the artwork feature images of potential virus hosts (bats, poultry, dromedary), a group of humans, a microscope, pills, a syringe and vaccine vial, protein structures, and an illustration of a human lung. The background is set in yellow and red colour.

What COVID-19 is teaching us

The virtual EMBL Conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ explored the importance of fundamental research, collaboration, and data science in containing the SARS-CoV-2 pandemic, and discussed opportunities to improve our response to pandemics in the future.

By Marius Bruer

Events

Gene Editing and Embryology Facility at EMBL Rome

Editing the mouse genome to study SARS-CoV-2 infection

To study how SARS-CoV-2 infects cells, the Gene Editing and Embryology Facility (GEEF) at EMBL Rome will generate mice that express a human version of a protein called ACE2. The mouse line will be shared with preclinical research collaborators carrying out vaccine and antibody trials, and with the…

By Rossana De Lorenzi

Science

SARS-CoV-2 viruses visible on proteins

Existing drugs can prevent SARS-CoV-2 from hijacking cells

Researchers evaluate how the new coronavirus rewires human proteins for its own replication, and identify several antiviral drugs ready for clinical trials

By Mehdi Khadraoui

Science

Scientists in the Hackett group at EMBL Rome doing lab work

Silencing the SARS-CoV-2 receptor with epigenetic modifications

EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…

By Rossana De Lorenzi

Science

Crystal selection for X-ray diffraction experiments.

Investigating the structure and mechanisms of coronavirus biomolecules

While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…

By Adam Gristwood

Science

Tissue culture plates in an incubator.

Understanding how SARS-CoV-2 behaves in the gut

Scientists at EMBL and Heidelberg University Hospital are studying how the novel coronavirus behaves in the gut to try to better understand its epidemiology and prevent its spread. To do this, they are combining advanced imaging and sequencing technologies to study coronavirus in human intestinal…

By Adam Gristwood

Science

Key visual for the virtual EMBL conference ‘SARS-CoV-2: Towards a New Era in Infection Research’. Credits: Aleksandra Krolik/EMBL

Improving our response to emerging pandemics

The emergence of previously unknown pathogens, such as the novel coronavirus SARS-CoV-2, raises many questions. To explore these questions in an international scientific forum, EMBL will host the virtual conference ‘SARS-CoV-2: Towards a New Era in Infection Research’ on 3 July. Invited…

By Marius Bruer

Events

Beamline Hamburg

Shining high-brilliance beams on coronavirus structure

EMBL researchers are studying COVID-19-related molecules by exposing them to high-brilliance X-ray beams. The Svergun group at EMBL Hamburg is using biological small-angle X-ray scattering (SAXS) as part of a global effort by scientists to elucidate the structural organisation of SARS-CoV-2…

By Adam Gristwood

Science

Automated sample changer and diffractometer at the ID30B X-ray crystallography beamline at ESRF Grenoble.

Facilitating COVID-19 structural biology research

EMBL and the European Synchrotron Radiation Facility (ESRF) restart the activities of the Joint Structural Biology Group in Grenoble to support coronavirus-related projects. A new initiative will allow users to be granted access to the High-Throughput Crystallisation (HTX) lab at EMBL and to a…

By Marius Bruer

Science

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