ProtVar: understanding missense variation in humans
Technology and innovation A new tool for the interpretation of missense variation in humans – ProtVar – will help enable drug discovery.
2023
technology-and-innovation
New releases: InterPro 94.0 and InterProScan 5.62-94.0
Updates from data resources InterPro 94.0 features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38,000 entries.
2023
updates-from-data-resources
MGnify just got bigger – new data, new AI opportunities
Updates from data resources EMBL-EBI's metagenomics data resource increases in size and supports groundbreaking AI tools for protein structure prediction.
2023
updates-from-data-resources
New releases: InterPro 93.0 and InterProScan 5.61-93.0
Updates from data resources InterPro now features hundreds of new methods integrated from partner databases, and InterProScan draws on over 38,000 entries. InterPro version 93.0 InterPro 93.0 integrates 300 new methods from the CDD (261), PANTHER (12), PROSITE profiles (17), SMART (9), TIGRFAMs (1) databases, and covers 81.7%…
2023
updates-from-data-resources
AlphaFold applications – a community assessment
Research highlights, Science Researchers use social media to share findings on how useful AlphaFold predictions are for different applications.
2022
research-highlightsscience
Shining a light on how bacteria interact
Research highlights, Science Machine learning has helped researchers uncover new insights into how bacteria infect host cells.
2022
research-highlightsscience
AlphaFold update – neglected tropical diseases
Updates from data resources Latest AlphaFold database update adds 27 new organisms and almost 200,000 new protein structure predictions relevant to neglected tropical diseases and antimicrobial resistance
2022
updates-from-data-resources
Characterising protein phosphosite function at scale
Science Researchers develop a new high-throughput approach to assess the functional significance of protein phosphosites.
2021
science
3D-Beacons Network: protein structure data, all in one place
Science 3D-Beacons Network acts as a one-stop shop for protein structures by combining and standardising data from several providers.
2021
science
Accessible 3D protein models to accelerate scientific discovery
Science DeepMind and EMBL-EBI to make millions of protein structure predictions freely available to the scientific community.
2021
science
The PROTACtable genome – a new route to drug discovery
Science Researchers establish a framework for identifying new drugs capable of exploiting a cell’s own machinery.
2021
science
Twinkle, twinkle, little nuclear pore complex
Picture of the week As perfect as a summer night sky, these nuclear pores help calibrate a customised super-resolution microscope in EMBL’s Ries group.
2021
picture-of-the-week
SARS-CoV-2 curtails immune response in the gut
Science EMBL scientists, together with collaborators from Heidelberg University, have provided further evidence of the gut’s role in COVID-19.
2021
science
EMBL Hamburg lights the way to folding next-level origami
Science Using EMBL Hamburg’s world-class structural biology infrastructure, researchers advance the folding of protein ‘origami’ designed in the lab.
2021
science
Pfam releases structures for every protein family
Science Thousands of new protein structure models, prected using deep learning, now available to explore
2021
science
Heating proteins to understand how genes work
Science A new paper from EMBL’s Savitski team and Typas group describes their work on E. coli and how it brings a greater understanding of the way genes function and interact.
2020
science
Solving the protein structure puzzle
Science How artificial intelligence can help us solve the mysteries of the protein universe
2020
science
A luminous larval love light
Picture of the week Those heart-shaped cells aren't just for show. They help tell the story of two proteins working together
2020
picture-of-the-week
Helping researchers identify host proteins used by coronavirus
Science EMBL scientists working in the groups of Matthias Hentze and Wolfgang Huber have created RBPbase – a database of RNA-binding proteins – to assist the identification of proteins that interact with the SARS-CoV-2 RNA genome.
2020
science
Exploring the beauty of proteins
Science Schoolchildren get creative with 3D protein structures
2019
science
First results from CSSB
Science EMBL scientists collaborate to develop new protocol for screening membrane protein stability
2019
science
Sex and diet affect proteotype
Science EMBL scientists have discovered that the proteome is substantially affected by both sex and diet
2019
science
Comprehensive protein data for drug development
Lab Matters PDBe-KB - new data resource for protein structure and function launches
2019
lab-matters
First interactive model of human cell division
Science Real-time tracking of proteins during mitosis is now possible using a 4D computer model
2018
science
Small code change, big effect
Science Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have developed a new method which enables researchers to label any protein of their choice with any of a wide variety of previously available compounds, in living cells, by introducing a single reactive…
2011
science
Sugarcoating fruit fly development
Science Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…
2009
science
Life savers in the gut
Science Researchers from the European Molecular Biology Laboratory (EMBL) have discovered that proteins that regulate the body’s iron household play a vital role in making sure enough nutrients and water are absorbed in the intestine. Mice lacking these proteins suffer from weight loss and…
2008
science
The closest look ever at native human tissue
Science Seeing proteins in their natural environment and interactions inside cells has been a longstanding goal. Using an advanced microscopy technique called cryo-electron tomography, researchers from the European Molecular Biology Laboratory (EMBL) have visualised proteins responsible for cell-cell…
2007
science
Casting the molecular net
Science Scientists at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital (Canada), the European Molecular Biology Laboratory (Germany), and Massachusetts Institute of Technology (USA) have created a new computational method called NetworKIN. This method uses biological networks to better…
2007
science
Mechanism of microRNAs deciphered
Science Over 30% of our genes are under the control of small molecules called microRNAs. They prevent specific genes from being turned into protein and regulate many crucial processes like cell division and development, but how they do so has remained unclear. Now researchers from the European Molecular…
2007
science
A signal that protects the liver from hepatitis and cancer
Science Liver cancer is one of the deadliest cancers worldwide; every year sees more than 400,000 new cases, and most of the victims die in less than one year. Despite extensive research, the underlying molecular mechanisms of the disease are poorly understood. A new study by researchers from the Mouse…
2007
science
Roadworks on the motorways of the cell
Science A cell is a busy place. In a permanent rush hour, molecules are transported along a dynamic motorway system made up of filaments called microtubules. Microtubules constantly grow and shrink and are rapidly assembled wherever a cargo needs to go, but during this transportation process they need to…
2006
science
Alleviating the burden of Multiple Sclerosis
Science Depression, coordination and speech problems, muscle weakness and disability are just a few of the symptoms of Multiple Sclerosis (MS). Researchers from the Mouse Biology Unit of the European Molecular Biology Laboratory (EMBL) in Italy and the Department of Neuropathology at the Faculty of…
2006
science
Cracking a virus protection shield
Science Ebola, measles and rabies are serious threats to public health in developing countries. Despite different symptoms all of the diseases are caused by the same class of viruses that unlike most other living beings carry their genetic information on a single RNA molecule instead of a double strand of…
2006
science
A balancing act between the sexes
Science Recent research at the European Molecular Biology Laboratory (EMBL) reveals new insights into how cells achieve equality between the sexes. A new link discovered between the membrane surrounding the nucleus and the male X-chromosome in fruit flies may play a crucial role in determining how active…
2006
science
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