A glimpse into the hexasome: 40 years on
Science Research from the Eustermann group at EMBL Heidelberg reveals how the packaging of DNA into hexasomes impacts the function of enzymes involved in gene regulation.
2023
science
Dispensing microscopy expertise
Lab Matters Home to some of Europe’s most cutting-edge tools in molecular biology, EMBL has long shared its expertise and access to these tools through an extensive repertoire of courses, conferences, seminars, and other training. And now included in this mix is a job shadowing programme at EMBL Imaging…
2023
lab-matters
Welcome: Gergely Papp
Lab Matters Together with his team, Gergely Papp pushes the frontiers of technology development in the field of structural biology.
2023
lab-matters
New EU-funded Project: Fragment-Screen
Lab Matters EMBL is one of the partners of this project that aims to accelerate drug discovery and development, bringing in expertise from EMBL Grenoble and EMBL-EBI.
2023
lab-matters
Solving the structure of a critical molecular editor
Science EMBL Grenoble scientists provide new insights into the function of an essential RNA editing enzyme.
2023
science
Ardan Patwardhan and Wim Hagen receive Scientific Achievement Award
Lab Matters The Royal Microscopical Society awarded Ardan Patwardhan and Wim Hagen with Scientific Achievement Award
2022
lab-matters
Ardan Patwardhan receives Scientific Achievement Award
Announcements The Royal Microscopical Society recognises Ardan Patwardhan’s contributions to the field of electron microscopy.
2022
announcements
Seeing antibiotics in action inside a pathogenic bacterium
Science New research by EMBL scientists shows at atomic detail how antibiotics affect the process of protein production inside bacteria.
2022
science
Shaping up the genome for cell division
Science Researchers have discovered the mechanism by which a family of DNA motor proteins packages loosely arranged strands of DNA into compact individual chromosomes during cell division.
2022
science
Capturing ‘snapshots’ of a crucial step in RNA splicing
Science The Galej group at EMBL Grenoble has recently obtained high resolution snapshots of a crucial step in RNA splicing involving the U2 snRNP complex, a crucial component of the human spliceosome.
2022
science
Solving molecular puzzles to find the perfect fit
Science Using cryo-EM and structural biology techniques, EMBL researchers have shown how two proteins of Legionella pneumophila interact. This finding sheds light on a mechanism critical to the infection process and could lead to the development of new drugs to treat pneumonia.
2021
science
A gallery of human RNA polymerases
Science New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.
2021
science
EMBL Imaging Centre launches first open call for users
Lab Matters The new EMBL Imaging Centre has announced its first open user call, and new project evaluation process and training opportunities.
2021
lab-matters
Welcome: Svetlana Dodonova
Lab Matters Svetlana Dodonova is one of EMBL's newest group leaders, leading a team of researchers who will study how genetic material is organised inside cells using structural biology approaches.
2021
lab-matters
Cryo-Electron Microscopy Service Platform supports research on protein transport
Lab Matters Giulia Zanetti from the Institute of Structural and Molecular Biology (ISMB) in London explains how the collaboration with the Cryo-Electron Microscopy Service Platform enabled her group to reveal the structure of protein transport complexes.
2021
lab-matters
Structural biology reveals new opportunities to combat tuberculosis
Science EMBL Hamburg’s Wilmanns and Kosinski groups have determined the detailed structure of a bacterial protein complex critical for tuberculosis infection.
2021
science
Welcome: Matthew Hartley
Lab Matters The challenges and opportunities when setting up a global archive for bioimages
2021
lab-matters
Seeing through a cell
Picture of the week Liang Xue used cryo-electron tomography to capture this detailed image of a Mycoplasma pneumoniae cell.
2021
picture-of-the-week
At the core of the Integrator complex
Science A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.
2021
science
Welcome: Timo Zimmermann
Lab Matters The EMBL Imaging Centre is scheduled to open in 2021 with Timo Zimmermann as Team Leader for advanced light microscopy technology development and service provision.
2021
lab-matters
Seeing deeper inside cells
Science While cryo-electron tomography (cryo-ET) was first envisioned in 1968, the advances the Mahamid group are bringing to this 3D method for studying molecules directly inside cells are new, and are likely to greatly expand its use.
2020
science
Welcome: Simone Mattei
Lab Matters The new team leader offering services in electron microscopy discusses his hopes and plans for the forthcoming EMBL Imaging Centre
2020
lab-matters
Flexible and protected – new findings on SARS-CoV-2 protein shed light on virus’s ability to infect cells
Science Researchers studied the spike protein on the surface of the SARS-CoV-2 virus. With its spikes, the virus binds to human cells and infects them. The study gave surprising insights into the spike protein, including an unexpected freedom of movement and a protective coat to hide it from antibodies.
2020
science
Visualising the cell’s molecular machinery in action
Science A new approach that allows researchers to see molecular machinery at work inside cells has offered a deeper understanding of how bacteria produce proteins and a unique glimpse into how they respond to antibiotics.
2020
science
Understanding chromosome organisation
Science EMBL scientists and collaborators help reveal the process by which enormous quantities of DNA are folded into cells.
2020
science
Investigating the structure and mechanisms of coronavirus biomolecules
Science While global research on coronaviruses has shed light on the function of many SARS-CoV-2 proteins, the role of some crucial components remains unknown. Researchers at EMBL Grenoble will use a range of structural biology methods to try to solve some of the puzzles of the molecular mechanics of…
2020
science
Understanding the influenza virus
Science The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza…
2020
science
Supporting international research on the structure of the coronavirus
Science EMBL Heidelberg reopens the Cryo-Electron Microscopy Service Platform to support coronavirus structural biology research.
2020
science
Photo-micropatterning advances structural cell biology
Science A new technique in cryo-EM
2019
science
A tRNA modifier at work
Science Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.
2019
science
Breaking the bottleneck in imaging data collection
Science Scientists develop software tools for automated acquisition of electron microscopy data
2019
science
Translating blue-sky research into the clinic
Lab Matters What does it take to create a vaccine or improve cancer therapies?
2018
lab-matters
More effective insulin thanks to first 3D image
Science New study reveals how to make therapeutic insulins more effective than they currently are
2018
science
How cells export and embed proteins in the membrane
Science Like an overprotective parent on the first day of school, a targeting factor sometimes needs a little push to let go of its cargo. Scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have visualised one such hand-over. They were the first to determine the structure…
2010
science
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