Müller Group Archives

9 December 2021 Colourful interwoven coils are displayed against a grid of small black and white photographic images.

A gallery of human RNA polymerases

New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

16 February 2021 An assembly of proteins in an enzyme, presented in a cartoon style.

Cellular modern art

This week's Picture of the Week, which could also be a masterpiece of modern art, shows the enzyme RNA polymerase III, an assembly of 17 individual proteins combined into this complex structure.

SCIENCE & TECHNOLOGY

2021

picture-of-the-weekscience-technology

8 February 2021 Illustration of a laboratory flask to the left of a microscope against an orange/grey background with a zoomed-in cut-out of the microscope view, which is colourful molecules.

Illustration of a laboratory flask to the left of a microscope against an orange/grey background with a zoomed-in cut-out of the microscope view, which is colourful molecules.

A better look at a human RNA polymerase

New EMBL research shows where & to what degree a component of cellular machinery known as RNA Pol III is mutated and becomes problematic.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

24 October 2018 Insulin receptor structural biology. IMAGE: Felix Weis and Christoph Müller / EMBL

More effective insulin thanks to first 3D image

New study reveals how to make therapeutic insulins more effective than they currently are

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

17 January 2018 With help from an external transcription factor (lavender, peach, and green), Pol III (grey) and its built-in transcription factor (yellow), create a cage around a cell’s DNA (plum). IMAGE: EMBL/Matthias Vorländer

With help from an external transcription factor (lavender, peach, and green), Pol III (grey) and its built-in transcription factor (yellow), create a cage around a cell’s DNA (plum). IMAGE: EMBL/Matthias Vorländer

Pol III enzyme grips DNA and begins reading fast

EMBL researchers uncover how a key enzyme that helps cells make new proteins starts its work

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

17 November 2016

New insights into RNA Polymerase I

Cryo EM reconstruction of RNA Polymerase I reveals details of how molecule binds and transcribes DNA

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

11 February 2016 The 3D structure shows how two transcription factors influence one another’s binding to a specific stretch of DNA – an interaction that is crucial for a heart to develop healthily. IMAGE: EMBL/C.Müller