When microbiomes collide
Science EMBL researchers used data from over 300 human faecal microbiota transplants to gain an ecological understanding of what happens when two gut microbiomes clash.
2022
science
Cell sorting enters a new dimension
Science EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.
2022
science
The impact of drugs on gut microbes is greater than we thought
Science Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…
2021
science
From stem cells to neurons
Science Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…
2020
science
Unravelling epigenetic reprogramming
Science A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…
2020
science
New insights into epigenetic modifications
Science Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.
2020
science
Genetic cut and paste at atomic resolution
Science Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…
2020
science
Re-trafficking proteins to fight Salmonella infections
Science Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…
2020
science
Enabling functional genomics studies in individual cells
Science Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…
2020
science
New insights into gene regulation
Science EMBL researchers investigate the role of a histone protein in regulating gene expression
2020
science
Finding your way around Platynereis dumerilii
Science EMBL researchers combine multiple datasets to develop expandable atlas of an entire animal
2020
science
How transcription factors work together
Science EMBL researchers have developed a method to observe interactions between transcription factors
2020
science
A classification tool for transcription factors
Science The software diffTF quantifies activity of transcription factors and predicts their mode of action
2019
science
Understanding a key player in melanoma
Science A new paper describes a unique mechanism of partner selectivity in transcription factors.
2019
science
Photo-micropatterning advances structural cell biology
Science A new technique in cryo-EM
2019
science
New perspectives on nuclear pores
Science EMBL researchers have published two new studies involving the nuclear pore complex
2019
science
Transcriptional hubs confer phenotypic robustness
Science Enhancers in Drosophila embryos gather together to preserve phenotypes under stressful conditions
2019
science
A tRNA modifier at work
Science Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.
2019
science
Actin crosslinking plays key role in tissue morphogenesis
Science New insights into mechanisms behind embryonic development
2019
science
Hydraulic force shapes mammalian embryos
Science Uncovering new role of fluid pressure in controlling embryo size and cell fate
2019
science
Breaking the bottleneck in imaging data collection
Science Scientists develop software tools for automated acquisition of electron microscopy data
2019
science
The Arctic Ocean: reservoir of marine viruses
Science Results from the Tara Oceans expedition reveal the Arctic Ocean as a cradle of viral biodiversity
2019
science
Catalogue of structural variants
Science Thorough characterisation of structural variants in human genomes
2019
science
ATP affects proteome-wide solubility
Science Scientists develop technology to measure how ATP concentration affects protein solubility in cells
2019
science
Many gut microbes may originate in the mouth
Science Many microbes traverse the oral-gut barrier
2019
science
Role reversal: RNA controls protein function
Science EMBL scientists identify RNA regulating protein behaviour in switch of normal roles
2019
science
New method to study gene expression in yeast cells
Science Scientists develop high-throughput yeast single-cell RNA sequencing method
2019
science
Structure of prodrug-transporter complex revealed
Science Scientists develop structural model that could help in the development of drugs with increased absorption rates
2019
science
New ways to look at protein-RNA networks
Science Researchers develop new method to analyse the entire protein-RNA network of the cell
2018
science
Time-resolved X-ray crystallography simplified
Science Speeding up time-resolved X-ray crystallography with EMBL beamline P14
2018
science
Transcription factors controlled by DNA sequence
Science EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
2018
science
Solving the structure of retromer
Science Retromer’s 3D structure improves understanding of cellular sorting and packaging
2018
science
X-rays reveal surprising shape of scaffolding protein
Science X-ray experiments show that scaffolding protein PDZK1 has a L-shaped conformation
2018
science
Cohesin: a glue for DNA
Science EMBL scientists discover how a component of the cohesin ring binds DNA
2018
science
The proteins behind hungry cells
Science EMBL researchers visualise the proteins needed to capture molecules and bring them into a cell
2018
science
Algal nuclear pore complex revealed
Science EMBL scientists reveal NPC architecture of algae
2018
science
New way to isolate DNA- and RNA-protein complexes
Science EMBL researchers develop method that simplifies the isolation of DNA- and RNA- protein complexes
2018
science
Reconstructing 3D shapes from unmeasurable data
Science Scientists at EMBL Hamburg determine shapes of intermediate states in dynamic biological systems
2018
science
Protein stability and solubility during cell cycle
Science EMBL scientists uncover large solubility and thermal stability changes of proteins during the cell cycle
2018
science
Counting condensins on chromosomes
Science EMBL scientists count and locate chromosomal proteins during cell duplication
2018
science
Insights into early cell life
Science New technique offers insight into early cell life
2018
science
Insights into the evolution of a signalling molecule
Science EMBL scientists discover how a molecule’s role changes from simple metabolite to instructive signal
2018
science
Your favourite reads of 2017
Lab Matters A look back at some of the most read stories on EMBL’s news website this year
2017
lab-matters
Research highlights
Science A summary of recent research highlights from EMBL
2017
science
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