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15 September 2022 The foreground shows two yellow pipes representing the human gastrointestinal tract coming together, representing the confluence of donor and recipient gut ecosystems. Bacteria can be seen as green shapes inside the pipes and various kinds of interactions between them are shown symbolically as a mixing of colours.

When microbiomes collide

Science EMBL researchers used data from over 300 human faecal microbiota transplants to gain an ecological understanding of what happens when two gut microbiomes clash.

2022

science

21 January 2022 The cross-section of a cell expressing a green fluorescently tagged protein and illuminated by a blue laser is visible in the foreground, surrounded by a vortex of cells

Cell sorting enters a new dimension

Science EMBL researchers, in collaboration with BD Biosciences, have demonstrated a new technology that allows rapid image-based sorting of cells. The new technology represents a major upgrade to flow cytometry and has applications in diverse life science fields.

2022

science

8 December 2021 An illustration of the human gut, with coloured shapes representing bacteria. Three different drugs and drug combinations are shown affecting the bacteria, represented by changes in colour

The impact of drugs on gut microbes is greater than we thought

Science Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…

2021

science

3 July 2020 stem cells neurons differentiation

From stem cells to neurons

Science Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…

2020

science

2 July 2020 epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

Science A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

2020

science

9 June 2020 This image shows the structure of a bacterial group II intron

Genetic cut and paste at atomic resolution

Science Researchers in the Marcia group at EMBL Grenoble and the De Vivo lab at the Italian Institute of Technology in Genoa have obtained some of the most detailed ever snapshots of the splicing process in systems known as group II self-splicing introns. The new insights will help scientists to develop…

2020

science

8 June 2020 Microscopic image showing a macrophage that has been infected with Salmonella (green), causing cellular cathepsins (red) to locate to the nucels (blue).

Re-trafficking proteins to fight Salmonella infections

Science Scientists including members of EMBL’s Typas group have investigated how immune cells called macrophages respond to infection by the intracellular pathogen Salmonella enterica. They discovered that Salmonella causes newly produced cathepsins to accumulate in the nuclei of infected cells to…

2020

science

1 June 2020 An illustration of single-cell RNA sequencing (scRNA-seq)

Enabling functional genomics studies in individual cells

Science Scientists at EMBL Heidelberg have developed a new method, called Targeted Perturb-seq (TAP-seq), which increases the scale and precision of functional genomics CRISPR–Cas9 screens by orders of magnitude. Their method overcomes limitations in previous applications of single-cell RNA sequencing,…

2020

science

11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Science Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.

2019

science

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