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EMBL Rome

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10 January 2025 Colourful image of mouse cells

Sweet gene regulation in the mammalian embryo

Researchers in the Boulard group at EMBL Rome demonstrated that the catalytic activity of the OGT enzyme is essential for embryonic development, and that when it’s reduced, embryo development is delayed – especially in males.

SCIENCE & TECHNOLOGY

2025

science-technology

22 November 2024

Celebrating 25 years of EMBL Rome

EMBL Rome celebrates its 25th anniversary this year – some impressions of the symposium and party organised for staff and alumni to mark this special occasion.

LAB MATTERS

2024

lab-matters

16 October 2024

All eyes on science!

EMBL Rome volunteers participated in the European Researchers’ Night organised by the CNR in Montelibretti, attended by over 1,500 visitors. They prepared activities and games reflecting the wide variety of projects conducted at the site and across EMBL.

LAB MATTERS

2024

lab-matters

1 May 2024 Alt Text: An artistic representation of gut microbes and sperm cells

Father’s gut microbes affect the next generation

Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.

SCIENCE & TECHNOLOGY

2024

science-technology

16 November 2023

New evidence on retinal function

A new study from the Asari group at EMBL Rome shows a different retinal function in awake mice compared to isolated retinal samples. These new insights could help to develop prosthetic devices that can act as a retina in the future.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

28 June 2023 Female scientist in white lab coat enjoying camaraderie of colleagues.

After EMBL: Urtė Neniškytė

EMBL Rome alumna Urtė Neniškytė returned to her native Lithuania, helping establish the Vilnius University-EMBL Partnership Institute and advance genome-editing technologies there.

PEOPLE & PERSPECTIVES

2023

alumnipeople-perspectives

1 June 2022

EMBL in Italy event held at GSK Vaccines in Siena

The GSK Vaccines site in Siena hosted the annual EMBL in Italy event. The hybrid meeting brought together industry leaders, representatives from biotech start-ups, data scientists, and researchers from academia.

CONNECTIONS

2022

alumniconnections

8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

8 June 2021 Purple, blue and yellow dots on a black background.

Dream team

At EMBL, we have many dream teams – groups of individuals who support each other, innovate, and work together. One of those dream teams bridges two core facilities at EMBL Rome.

SCIENCE & TECHNOLOGY

2021

picture-of-the-weekscience-technology

28 April 2021 Artistic representation of brain and DNA

Uniting strengths to expand research

The European Molecular Biology Laboratory and the Italian Institute of Technology have signed an agreement to expand the scope of their collaboration to include areas of mutual interest and in the context of EMBL’s 2022-2026 Programme “Molecules to Ecosystems”.

CONNECTIONSLAB MATTERS

2021

connectionslab-matters

16 March 2021 Pink blooming tree in front of functional building.

Italian Spring

EMBL’s site in Monterotondo has recently been blessed with blue skies and sunshine, leading to trees blooming early on campus.

LAB MATTERS

2021

lab-matterspicture-of-the-week

29 January 2021 Flags of EMBL, Italy and CNR

Strengthening collaborations in Italy

EMBL and CNR have signed a memorandum of understanding to strengthen scientific cooperation. The agreement will foster collaborative projects and integrate them within the European and global scientific landscape.

CONNECTIONSLAB MATTERS

2021

connectionslab-matters

8 October 2020 Alvaro Crevenna, heads EMBL Rome’s Microscopy Facility. Credit: EMBL

Beyond the lens – microscopy at EMBL Rome

Research facilities play a crucial role in the advancement of science by supporting scientists with specialised expertise and state-of-the-art equipment. The Microscopy Facility at EMBL Rome exemplifies this role by making a wide variety of light microscopy technologies available to its researchers…

LAB MATTERSSCIENCE & TECHNOLOGY

2020

lab-mattersscience-technology

2 July 2020 epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

29 June 2020 Gene Editing and Embryology Facility at EMBL Rome

Editing the mouse genome to study SARS-CoV-2 infection

To study how SARS-CoV-2 infects cells, the Gene Editing and Embryology Facility (GEEF) at EMBL Rome will generate mice that express a human version of a protein called ACE2. The mouse line will be shared with preclinical research collaborators carrying out vaccine and antibody trials, and with the…

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

9 June 2020 Mouse embryonic fibroblasts and their cell skeletons

Glow-in-the-dark cell skeletons

This image shows mouse embryonic fibroblasts (MEFs), their cell skeletons (green) and nuclei (blue) under a confocal microscope, photographed by Julia Hansen in the lab of Matthieu Boulard at EMBL Rome.

SCIENCE & TECHNOLOGY

2020

picture-of-the-weekscience-technology

31 May 2010 This microscopy image shows that, in a mouse embryo, MiR451 (dark purple) is produced only in the liver, where red blood cells are being formed at this developmental stage. Image credits: Kasper Rasmussen/EMBL

Making enough red blood cells

Red blood cells, the delivery men that take oxygen to cells all around the body, have short lives. To keep enough of them in circulation, the human body produces around 2 million of these cells every second – even more in response to challenges like severe blood loss. In a study published today…

SCIENCE & TECHNOLOGY

2010

sciencescience-technology

10 December 2009 These microscopy images demonstrate the effects of Notch signalling on the hearts of newborn mice (top) and of adult mice after a heart attack (bottom). In a normal neonatal heart (top left), the two major heart chambers (ventricles) are clearly separated by tissue (septum). But when Notch signalling was inactivated in an embryo’s heart muscle cells, the septum between the ventricles of the newborn mouse’s heart was incomplete (asterisk). The same defect commonly occurs in humans with congenital heart disease, often leading to circulatory distress. In the images of adult hearts (bottom), healthy tissue is shown in red and damaged tissue in blue. Normally (bottom left), a heart attack causes extensive tissue damage to the left ventricle (right-hand cavity), but mice in which Notch was re-activated after the heart attack had reduced tissue damage (bottom right) and improved cardiac function. Image credit: EMBL

From fruit fly wings to heart failure. Why Not(ch)?

Almost a century after it was discovered in fruit flies with notches in their wings, the Notch signalling pathway may come to play an important role in the recovery from heart attacks. In a study published today in Circulation Research, scientists at the European Molecular Biology Laboratory (EMBL)…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

21 September 2009 This microscopy image, taken ten days after injury, shows that the muscle fibres of normal mice (left) had re-grown, while in mice which couldn’t boost C/EBPβ production (right) there were still many fibres that had not regenerated (arrowheads), and the tissue had a number of scars (arrows).

To regenerate muscle, cellular garbage men must become builders

For scientists at the European Molecular Biology Laboratory (EMBL) in Monterotondo, Italy, what seemed like a disappointing result turned out to be an important discovery. Their findings, published online this week in the journal Proceedings of the National Academy of Sciences (PNAS), provide…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

13 September 2009 In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

SCIENCE & TECHNOLOGY

2009

sciencescience-technology

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