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Galej Group

Structure and function of RNA-protein complexes

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Meet the authors Q&A

Wojtek Galej

Molecular Cell published an interview with Wojtek and his colleagues, Max Wilkinson and Sebastian Fica from the Nagai group reflecting on the last 6 years of their work on the spliceosome structure. It is the first paper to go through the Cell Press Community Review pilot scheme, allowing…


Ci spliceosome intermediate

Wojtek Galej

The latest #cryoEM structure from Nagai group at MRC LMB in Cambridge identifying a new spliceosome assembly intermediate (Ci complex) is now published in Molecular Cell. The paper contains the most complete and accurate depiction of the catalytic spliceosome to date and identifies a new functional…


A new paper on the Integrator complex

Wojtek Galej

Our newest paper describing the structure of the catalytic core of the Integrator complex is online now in Molecular Cell. Integrator complex was discovered more than 15 years ago as a specialised endonuclease responsible for the 3’-end processing of spliceosomal snRNAs. More recent studies…


Welcome to the newcomers

Wojtek Galej

A warmly welcome to our 2 newest lab members, Angelique and Sunny! Angelique joined as a research technician, after spending 5 years in Irina Gutsche’s group at IBS in Grenoble. Sunny joined as a new postdoc in November, after completing her PhD in Patrick Cramer’s group at MPI-BPC in…


Prime Minister Award for Michal Razew

Wojtek Galej

Congratulations to Michal Razew, EIPOD4 postdoctoral fellow in the lab, for receiving the Prime Minister of Poland award for his PhD dissertation at the International Institute of Molecular and Cell Biology in Warsaw.


A new spliceosome assembly intermediate identified

Wojtek Galej

Check out our latest pre-print from the Nagai group identifying a new spliceosome assembly intermediate. The most complete and accurate depiction of the catalytic spliceosome to date; 9 datasets, 12 focused maps, 4 years in making. Fantastic effort by Max Wilkinson and Sebastian Fica.…

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