Structure and function of RNA-protein complexes
A warm welcome to Simonas and Mani, our two newest lab members! Manikandan Parthasarathy did his PhD at the Indian Institute of Science under the supervision of Prof. Mahavir Singh, where he investigated the structure and assembly of type III TA systems from E. coli. He joined EMBL EIPOD-LinC…
Our group was well represented at this year’s RNA Society meeting in Singapore. We presented posters about the Integrator complex (Michal), U2 snRNP (Jonas) and a talk on the tri-snRNP assembly intermediate (Wojtek).It was great to see our two former PhD students, Jonas and Moritz, who keep their…
Jiangfeng Zhao was awarded Marie-Curie postdoctoral fellowship from the European Commission to study the assembly of splicing complexes in mammals. Congratulations!
Our latest collaboration with Sarah Offley and Alessandro Gardini group from the Wistar Institute provides new insights into the structure and function of the previously uncharacterized protein associated with the Integrator complex. We used functional genomics to show that INTS15 is a core…
Jonas Tholen is a graduate student winner of the 2023 Scaringe award from the RNA Society for his work on the U2 snRNP structure. Big congratulations !
Congratulations to our newest PhD, Jonas Tholen!!! Jonas determined structures of several U2 snRNP complexes and defended his thesis at the University of Heidelberg in November this year. Well done Jonas!
Great scientific exchanges and leisure activities during our joint retreat with Eustermann group from EMBL Heidelberg. We spent 3 days together at a beautiful venue of Château de Bournel (France).Looking forward to the next one!
Check out our latest review in Current Opinion in Structural Biology summarizing recent progress in mechanistic studies of the spliceosome.
The summer is here!
Our brief summary of the recent progress in understanding the structure and function of the Integrator complex was just published in Transcription. Moritz M. Pfleiderer & Wojciech P. Galej (2022) Emerging insights into the function and structure of the Integrator complex. Transcription,…