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stem cell

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20 March 2022 Portrait photo of EMBL Group Leader Judith Zaugg against a green background.

Judith Zaugg from EMBL Heidelberg receives ERC Consolidator Grant

Lab Matters Judith Zaugg, Group Leader at EMBL Heidelberg, has been awarded an ERC Consolidator Grant of €2 million funded under the European Union’s Horizon Europe research and innovation programme. Over the next five years, the grant will enable her group to study cellular interactions in the human bone…

2022

lab-matters

3 August 2021 illustration of health care providers around a big heart

All heart

Alumni A community of scientists is looking at the estimated three billion heart muscle cells in a human heart to better understand heart disease.

2021

alumni

4 March 2021 An illustration of single-cell RNA sequencing (scRNA-seq)

Induced pluripotent stem cells reveal causes of disease

Science Scientists in the Stegle group and colleagues have studied induced pluripotent stem cells from around 1,000 donors to identify correlations between individual genetic variants and altered gene expression. They linked more than 4,000 of the genetic variants responsible for altered expression…

2021

science

2 December 2020 The image is a green coloured cell, with a wild and textured surface which is composed of many different shapes and shadows.

Scratching the surface on cell differentiation

Science Scientists in the Diz-Muñoz group at EMBL Heidelberg are working to build understanding of the role that mechanical properties play in affecting cell behaviour – a young and rapidly developing field of study. They have developed and successfully used a highly specialised technique to manipulate…

2020

science

3 July 2020 stem cells neurons differentiation

From stem cells to neurons

Science Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…

2020

science

4 February 2020

From cosmetics to blood cells

Picture of the week Morgan Oatley and her colleagues in Christophe Lancrin’s group investigated how haematopoietic stem cells emerge from the endothelium in developing mouse embryos.

2020

picture-of-the-week

24 November 2016

Chromatin cartographer

Alumni EMBL alumnus Jop Kind reflects on the questions that led him to this year’s John Kendrew Award

2016

alumni

13 September 2009 In normal skin (left), the stem cells at the base, shown in green, differentiate into skin cells, shown in red. In mice whose skin has neither C/EBPα nor C/EBPβ (middle), this differentiation is blocked: green-labeled stem cells appear in upper layers of skin, and there are no differentiated skin cells (no red staining). This also happens at the initial stages of basal cell carcinomas. In skin where C/EBPα is present but has lost its capacity to interact with E2F, a molecule that regulates the cell cycle (right), skin cells start differentiating abnormally, before they have properly exited the stem cell ‘program’ (yellow/orange). This is similar to what is observed in the initial stages of squamous cell carcinomas, a more aggressive and invasive skin tumour.

How stem cells make skin

Science Stem cells have a unique ability: when they divide, they can either give rise to more stem cells, or to a variety of specialised cell types. In both mice and humans, a layer of cells at the base of the skin contains stem cells that can develop into the specialised cells in the layers above.…

2009

science

8 April 2008

An unexpected way to cause leukaemia

Science Leukaemia – cancer of blood or bone marrow – is caused by mutations that allow defective blood cells to accumulate and displace healthy blood. To devise effective therapies it is crucial to know which mutations cause leukaemia and which cell type gives rise to leukaemic cells. Researchers from…

2008

science

4 May 2007

A matter of force

Science When a cell divides, normally the result is two identical daughter cells. In some cases however, cell division leads to two cells with different properties. This is called asymmetric cell division and plays an important role in embryonic development and the self-renewal of stem cells. Researchers…

2007

science

4 September 2005

A new link between stem cells and tumors

Science Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg and the Institute of Biomedical Research of the Parc Científic de Barcelona (IRB-PCB) have now added key evidence to claims that some types of cancer originate with defects in stem cells. The study, reported this week in…

2005

science

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