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müller

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9 December 2021 Colourful interwoven coils are displayed against a grid of small black and white photographic images.

A gallery of human RNA polymerases

Science New structural biology research provides fundamental information critical to understanding enzyme mutations connected to rare diseases and cancers.

2021

science

11 July 2019 Structure of the Elongator complex

A tRNA modifier at work

Science Using cryo-EM, scientists have determined the structure of a large protein complex called Elongator.

2019

science

2 May 2010 These microscopy images show the region of the embryo larva that will develop into the adult fruit fly’s wing. In cells genetically manipulated so that PR-DUB cannot remove the gene-silencing tag (left), a gene which would normally be silenced becomes turned on (red) - a situation which is corrected when PR-DUB’s activity is restored (right). Image credits: J.Mueller/EMBL.

Tags on, tags off

Science During embryonic development, proteins called Polycomb group complexes turn genes off when and where their activity must not be present, preventing specialised tissues and organs from forming in the wrong places. They also play an important role in processes like stem cell differentiation and…

2010

science

28 May 2009

Sugarcoating fruit fly development

Science Proteins are the executive agents that carry out all processes in a cell. Their activity is controlled and modified with the help of small chemical tags that can be dynamically added to and removed from the protein. 25 years after its first discovery, researchers at the European Molecular Biology…

2009

science

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