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Influenza Archives | EMBL

The Influenza virus

Understanding the influenza virus

The infectious disease commonly known as flu is caused by the influenza virus. It spreads around the world in seasonal outbreaks, causing millions of infections and hundreds of thousands of deaths each year. Stephen Cusack, Head of EMBL Grenoble, has been studying different aspects of the influenza virus for 30 years. Here, he describes how the influenza virus functions, the technologies that are helping researchers to understand it, and why it’s necessary to constantly develop new drugs.

By Fabian Oswald

Science

Influenza polymerase (light cyan) in the process of synthesising messenger RNA (slate blue).

Paving the way for new flu drugs

Snapshots of the flu virus replication machine in action

By Mathias Jäger

Science

Mutations at the amino acid shown in orange (isoleucine 38) lead to reduced susceptibility to the drug. IMAGE - Stephen Cusack, EMBL

Flu’s response to new drug explored

EMBL scientists investigate how influenza virus responds to new drug treatment

By Iris Kruijen

Science

Different inhibitors (yellow, grey) fill the cave-like active site of the cap-snatching protein (the endonuclease, in green) differently, even though they all bind to the active site’s two metal ions (magenta).

Catching the cap-snatcher

Researchers at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have determined the detailed 3-dimensional structure of part of the flu virus’ RNA polymerase, an enzyme that is crucial for influenza virus replication. This important finding is published today in PLoS Pathogens. The research was done on the 2009 pandemic influenza strain but it will […]

By Guest author(s)

Science

Flu fighters

Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This partnership should promote the joint development of new and innovative drug-candidates to fight both seasonal and […]

By Guest author(s)

Science

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