Epigenetics Archives | EMBL

EMBL scientists investigate rare lung disease

Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients with the disease with those of healthy individuals. Instead of finding a single clear cause, their results showed large epigenetic disturbances.

By Fabian Oswald


SPEN protein (green) in living cells. Credit: François Dossin

How females shut off their second X chromosome

Scientists provide important new insights into the molecular basis of X-inactivation

By Mehdi Khadraoui



Understanding molecular mechanisms of ageing

Understanding how ageing works at a molecular level

By Oana Stroe


A model of CRISPR/Cas9

Wielding the genetic scissors

What CRISPR may bring for the future of biology, and how it is used at EMBL

By Fabian Oswald


How cellular signalling controls chromatin modification. IMAGE: Aleksandra Krolik/EMBL

Transcription factors controlled by DNA sequence

EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation

By Patrick Mueller


In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

The scientific origins of Edith Heard

EMBL’s next Director General reflects on the questions that drive her research

By Guest author(s)


Daniel Elias Martin Herranz EMBL-EBI

PhD goals: why not start a company?

EMBL-EBI PhD student launches start-up focusing on epigenetics and wellbeing

By Oana Stroe

Lab Matters

Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories

By Iris Kruijen


This mouse ovary and these immature eggs (in blue), can be used to study patterns of DNA methylation that affect only females.

Welcome: Matthieu Boulard

New EMBL group leader investigates the mystery of heritable gene silencing

By Sarah B. Puschmann


Portrait of Edith Heard

Edith Heard awarded Grand Prix Inserm 2017

EMBL Director General elect, Edith Heard, awarded 2017’s Grand Prix Inserm for her work in epigenetics

By Berta Carreño

Lab Matters


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