The ‘long read’ for cancer
Science Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.
2023
science
Studying epigenetic regulation at the single-molecule level
Science In a first-of-its-kind study, EMBL researchers have shown how DNA methylation across the genome contributes to the precise regulation of gene expression.
2023
science
ERC Consolidator Grant success at EMBL
Lab Matters EMBL Rome group leader Jamie Hackett receives EUR 2 million for the ModLogic project, aimed at understanding how chromatin modifications impact gene activity.
2023
lab-matters
A metaphor for epigenetic inheritance
Science Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration
2022
science
Welcome: Ana Boskovic
Lab Matters The new group leader at EMBL Rome will study how embryos can inherit non-genetic information from their parents that causes stable and heritable effects
2021
lab-matters
Unravelling epigenetic reprogramming
Science A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…
2020
science
Silencing the SARS-CoV-2 receptor with epigenetic modifications
Science EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…
2020
science
New insights into epigenetic modifications
Science Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.
2020
science
EMBL scientists investigate rare lung disease
Science Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…
2020
science
How females shut off their second X chromosome
Science Scientists provide important new insights into the molecular basis of X-inactivation
2020
science
Understanding molecular mechanisms of ageing
Science Understanding how ageing works at a molecular level
2019
science
Wielding the genetic scissors
Science What CRISPR may bring for the future of biology, and how it is used at EMBL
2019
science
Transcription factors controlled by DNA sequence
Science EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
2018
science
The scientific origins of Edith Heard
Science EMBL’s next Director General reflects on the questions that drive her research
2018
science
PhD goals: why not start a company?
Lab Matters EMBL-EBI PhD student launches start-up focusing on epigenetics and wellbeing
2018
lab-matters
Chromatin usage reveals developmental trajectories
Science EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories
2018
science
Welcome: Matthieu Boulard
Science New EMBL group leader investigates the mystery of heritable gene silencing
2018
science
Edith Heard awarded Grand Prix Inserm 2017
Lab Matters EMBL Director General elect, Edith Heard, awarded 2017’s Grand Prix Inserm for her work in epigenetics
2017
lab-matters
New name for EMBL’s site in Italy
Lab Matters EMBL’s unit in Italy changes name to better reflect new research focuses and highlight its location
2017
lab-matters
Welcome: Jamie Hackett
Science Meet Monterotondo’s new group leader for epigenetic reprogramming and inheritance, Jamie Hackett
2017
science
Embryos use ancient viral DNA
Science EMBL scientists detect important function of genetic sequence our ancestors assimilated from a virus
2017
science
A race against the ageing clock
Science EMBL-EBI researchers identify mouse epigenetic clock that could help scientists understand ageing
2017
science
Strengthening links with Italian research community
Lab Matters EMBL’s Monterotondo site strengthens links with the Italian scientific community
2017
lab-matters
BLUEPRINT project delivers
Science BLUEPRINT: EMBL-EBI and the push to decipher the blood epigenome
2016
science
Linking DNA modification and gene expression
Science New method is first to enable parallel profiling of the transcriptome and epigenome of a single cell.
2016
science
Digitally human: texting life ahead
Lab Matters Giuseppe Testa reflects on the myriad intersections of our digital and biological lives.
2015
lab-matters
Life in 3D
Science EMBL scientists map ‘switches’ for distant control of gene expression.
2015
science
11th EMBL Transcription and Chromatin conference
Events Experts from multiple fields come together to understand how the instructions in genes are read
2014
events
Surprisingly stable long-distance relationships
Science Surprising finding: enhancers find their targets long before activation in Drosophila embryos
2014
science
Taken out of context
Science Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA
2014
science
Insights into genetics of cleft lip
Science How a DNA stretch influences face formation and contributes to common congenital malformations
2014
science
Of flies and men
Science What do you get when you dissect 10 000 fruit-fly larvae? A team of researchers led by the EMBL- European Bioinformatics Institute (EMBL-EBI) in the UK and the Max Planck Institute of Immunobiology and Epigenetics (MPI) in Germany has discovered a way in which cells can adjust the activity of many…
2012
science
New revelations in epigenetic control shed light on breast cancer
Science Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
2008
science
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