A new genetic tool helps researchers uncover the logic of gene regulation
Researchers use synthetic biology approaches to test hundreds of DNA sequences for their effect on regulating gene expression.
SCIENCE & TECHNOLOGY2026
science-technology
Inside the genome: insights from the ‘Brain (epi)genome’ conference
A recent EMBO workshop brought together researchers who are expanding our understanding of how layers of genetic and epigenetic regulation underlie critical brain functions.
SCIENCE & TECHNOLOGY2026
science-technology
Sweet gene regulation in the mammalian embryo
Researchers in the Boulard group at EMBL Rome demonstrated that the catalytic activity of the OGT enzyme is essential for embryonic development, and that when it’s reduced, embryo development is delayed – especially in males.
SCIENCE & TECHNOLOGY2025
science-technology
Cute molecules and the scientists who adore them: Sofia Rucli
Sofia Rucli, postdoc at EMBL Rome, talks about her relationship with the protein OGT, a molecular ‘candy man’ of the cell.
PEOPLE & PERSPECTIVES2024
people-perspectives
Silencing in action: how cells ‘repress’ genomic remnants of ancient viruses
Researchers have identified key cellular control sites that regulate gene expression and prevent the activation of ancient viral sequences in the genome.
SCIENCE & TECHNOLOGY2024
science-technology
An epigenome editing toolkit to dissect the mechanisms of gene regulation
A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.
SCIENCE & TECHNOLOGY2024
science-technology
Father’s gut microbes affect the next generation
Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.
SCIENCE & TECHNOLOGY2024
science-technology
Can the effects of the environment cross generations?
Scientists at EMBL Rome are developing new paradigms to study the impact of diverse environmental factors on reproduction in mammals and disease risk in their progeny.
EMBLetc2023
The ‘long read’ for cancer
Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.
2023
science
Studying epigenetic regulation at the single-molecule level
In a first-of-its-kind study, EMBL researchers have shown how DNA methylation across the genome contributes to the precise regulation of gene expression.
2023
science
ERC Consolidator Grant success at EMBL
EMBL Rome group leader Jamie Hackett receives EUR 2 million for the ModLogic project, aimed at understanding how chromatin modifications impact gene activity.
EMBL ANNOUNCEMENTSLAB MATTERS2023
embl-announcementslab-matters
A metaphor for epigenetic inheritance
Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration
SCIENCE & TECHNOLOGY2022
sciencescience-technology
Welcome: Ana Boskovic
The new group leader at EMBL Rome will study how embryos can inherit non-genetic information from their parents that causes stable and heritable effects
LAB MATTERSPEOPLE & PERSPECTIVES2021
lab-matterspeople-perspectives
Unravelling epigenetic reprogramming
A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Silencing the SARS-CoV-2 receptor with epigenetic modifications
EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
New insights into epigenetic modifications
Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic modification.
SCIENCE & TECHNOLOGY2020
sciencescience-technology
EMBL scientists investigate rare lung disease
Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…
SCIENCE & TECHNOLOGY2020
sciencescience-technology
How females shut off their second X chromosome
Scientists provide important new insights into the molecular basis of X-inactivation
SCIENCE & TECHNOLOGY2020
sciencescience-technology
Understanding molecular mechanisms of ageing
Understanding how ageing works at a molecular level
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Wielding the genetic scissors
What CRISPR may bring for the future of biology, and how it is used at EMBL
SCIENCE & TECHNOLOGY2019
sciencescience-technology
Transcription factors controlled by DNA sequence
EMBL scientists gain mechanistic insights into how cellular signalling controls gene regulation
SCIENCE & TECHNOLOGY2018
sciencescience-technology
The scientific origins of Edith Heard
EMBL’s next Director General reflects on the questions that drive her research
PEOPLE & PERSPECTIVES2018
people-perspectivesscience
PhD goals: why not start a company?
EMBL-EBI PhD student launches start-up focusing on epigenetics and wellbeing
LAB MATTERSPEOPLE & PERSPECTIVES2018
lab-matterspeople-perspectives
Chromatin usage reveals developmental trajectories
EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories
SCIENCE & TECHNOLOGY2018
sciencescience-technology
Welcome: Matthieu Boulard
New EMBL group leader investigates the mystery of heritable gene silencing
PEOPLE & PERSPECTIVES2018
people-perspectivesscience
Edith Heard awarded Grand Prix Inserm 2017
EMBL Director General elect, Edith Heard, awarded 2017’s Grand Prix Inserm for her work in epigenetics
EMBL ANNOUNCEMENTSLAB MATTERS2017
embl-announcementslab-matters
New name for EMBL’s site in Italy
EMBL’s unit in Italy changes name to better reflect new research focuses and highlight its location
EMBL ANNOUNCEMENTSLAB MATTERS2017
embl-announcementslab-matters
Welcome: Jamie Hackett
Meet Monterotondo’s new group leader for epigenetic reprogramming and inheritance, Jamie Hackett
PEOPLE & PERSPECTIVES2017
people-perspectivesscience
Embryos use ancient viral DNA
EMBL scientists detect important function of genetic sequence our ancestors assimilated from a virus
SCIENCE & TECHNOLOGY2017
sciencescience-technology
A race against the ageing clock
EMBL-EBI researchers identify mouse epigenetic clock that could help scientists understand ageing
SCIENCE & TECHNOLOGY2017
sciencescience-technology
Strengthening links with Italian research community
EMBL’s Monterotondo site strengthens links with the Italian scientific community
CONNECTIONSLAB MATTERS2017
connectionslab-matters
BLUEPRINT project delivers
BLUEPRINT: EMBL-EBI and the push to decipher the blood epigenome
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Linking DNA modification and gene expression
New method is first to enable parallel profiling of the transcriptome and epigenome of a single cell.
SCIENCE & TECHNOLOGY2016
sciencescience-technology
Digitally human: texting life ahead
Giuseppe Testa reflects on the myriad intersections of our digital and biological lives.
LAB MATTERS2015
lab-matters
Life in 3D
EMBL scientists map ‘switches’ for distant control of gene expression.
SCIENCE & TECHNOLOGY2015
sciencescience-technology
11th EMBL Transcription and Chromatin conference
Experts from multiple fields come together to understand how the instructions in genes are read
SCIENCE & TECHNOLOGY2014
eventsscience-technology
Surprisingly stable long-distance relationships
Surprising finding: enhancers find their targets long before activation in Drosophila embryos
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Taken out of context
Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Insights into genetics of cleft lip
How a DNA stretch influences face formation and contributes to common congenital malformations
SCIENCE & TECHNOLOGY2014
sciencescience-technology
Of flies and men
What do you get when you dissect 10 000 fruit-fly larvae? A team of researchers led by the EMBL- European Bioinformatics Institute (EMBL-EBI) in the UK and the Max Planck Institute of Immunobiology and Epigenetics (MPI) in Germany has discovered a way in which cells can adjust the activity of many…
SCIENCE & TECHNOLOGY2012
sciencescience-technology
New revelations in epigenetic control shed light on breast cancer
Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…
SCIENCE & TECHNOLOGY2008
sciencescience-technology
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