22 March 2023 Artistic representation that features a long, winding helix joining together a doughnut-figure to a small shaggy ball to indicate the connections long-read sequencing can make about DNA mutations.

The ‘long read’ for cancer

Science Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.



8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Science Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration



30 March 2021 Ana Boskovic sitting in her office

Welcome: Ana Boskovic

Lab Matters The new group leader at EMBL Rome will study how embryos can inherit non-genetic information from their parents that causes stable and heritable effects



2 July 2020 epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

Science A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…



25 June 2020 Scientists in the Hackett group at EMBL Rome doing lab work

Silencing the SARS-CoV-2 receptor with epigenetic modifications

Science EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…



22 May 2020

EMBL scientists investigate rare lung disease

Science Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…



5 May 2017

Welcome: Jamie Hackett

Science Meet Monterotondo’s new group leader for epigenetic reprogramming and inheritance, Jamie Hackett



20 August 2015

Life in 3D

Science EMBL scientists map ‘switches’ for distant control of gene expression.



25 June 2014

Taken out of context

Science Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA



19 July 2012 The female (left) fruit fly, Drosophila melanogaster, is larger than the male (right). Image credit: EMBL.

Of flies and men

Science What do you get when you dissect 10 000 fruit-fly larvae? A team of researchers led by the EMBL- European Bioinformatics Institute (EMBL-EBI) in the UK and the Max Planck Institute of Immunobiology and Epigenetics (MPI) in Germany has discovered a way in which cells can adjust the activity of many…



6 March 2008

New revelations in epigenetic control shed light on breast cancer

Science Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…



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