epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo…

By Rossana De Lorenzi


Scientists in the Hackett group at EMBL Rome doing lab work

Silencing the SARS-CoV-2 receptor with epigenetic modifications

EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of…

By Rossana De Lorenzi


New insights into epigenetic modifications

Scientists at EMBL Rome unveil the mechanism behind the most studied epigenetic…

By Rossana De Lorenzi


EMBL scientists investigate rare lung disease

Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure…

By Fabian Oswald


SPEN protein (green) in living cells. Credit: François Dossin

How females shut off their second X chromosome

Scientists provide important new insights into the molecular basis of…

By Mehdi Khadraoui



Understanding molecular mechanisms of ageing

Understanding how ageing works at a molecular…

By Oana Stroe


A model of CRISPR/Cas9

Wielding the genetic scissors

What CRISPR may bring for the future of biology, and how it is used at…

By Fabian Oswald


How cellular signalling controls chromatin modification. IMAGE: Aleksandra Krolik/EMBL

Transcription factors controlled by DNA sequence

EMBL scientists gain mechanistic insights into how cellular signalling controls gene…

By Patrick Mueller


In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

The scientific origins of Edith Heard

EMBL’s next Director General reflects on the questions that drive her…

By Guest author(s)


Daniel Elias Martin Herranz EMBL-EBI

PhD goals: why not start a company?

EMBL-EBI PhD student launches start-up focusing on epigenetics and…

By Oana Stroe

Lab Matters

Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

EMBL scientists show how chromatin usage in individual cells reveals developmental…

By Iris Kruijen


This mouse ovary and these immature eggs (in blue), can be used to study patterns of DNA methylation that affect only females.

Welcome: Matthieu Boulard

New EMBL group leader investigates the mystery of heritable gene…

By Sarah B. Puschmann



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