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Tag:

epigenetics

Year
9 May 2024

An epigenome editing toolkit to dissect the mechanisms of gene regulation

Science & Technology A study from the Hackett group at EMBL Rome led to the development of an epigenetic editing system that allows to precisely program chromatin modifications at any specific position in the genome, to understand their causal role in transcription regulation.

2024

science-technology

1 May 2024 Alt Text: An artistic representation of gut microbes and sperm cells

Father’s gut microbes affect the next generation

Science & Technology Scientists from EMBL Rome and EMBL Heidelberg found that disrupting the gut microbiome of male mice increases the risk of disease in their offspring. Their findings suggest that a father’s pre-conception environment can have lifelong effects on offspring.

2024

science-technology

22 March 2023 Artistic representation that features a long, winding helix joining together a doughnut-figure to a small shaggy ball to indicate the connections long-read sequencing can make about DNA mutations.

The ‘long read’ for cancer

Using Oxford Nanopore long-read sequencing, EMBL scientists sequenced a primary childhood brain tumour known as a medulloblastoma, uncovering a novel complex mutation pattern.

2023

science

31 January 2023

ERC Consolidator Grant success at EMBL

EMBL AnnouncementsLab Matters EMBL Rome group leader Jamie Hackett receives EUR 2 million for the ModLogic project, aimed at understanding how chromatin modifications impact gene activity.

2023

embl-announcementslab-matters

8 April 2022 a metaphor for the process of epigenetic inheritance

A metaphor for epigenetic inheritance

Science & Technology Recent studies from the Hackett group at EMBL Rome have revealed new insights on the mechanism regulating transmission of non-genetic information during embryonic development, and inspired a scientific illustration

2022

sciencescience-technology

30 March 2021 Ana Boskovic sitting in her office

Welcome: Ana Boskovic

Lab MattersPeople & Perspectives The new group leader at EMBL Rome will study how embryos can inherit non-genetic information from their parents that causes stable and heritable effects

2021

lab-matterspeople-perspectives

2 July 2020 epigenetic reprogramming, epigenetic memory, Hackett group

Unravelling epigenetic reprogramming

Science & Technology A study conducted by the Hackett group at EMBL Rome has identified key factors controlling the complex system of gene regulation during early embryo development, shedding new light on the mechanisms behind these events and on their evolutionary implications. Their findings are published in Nature…

2020

sciencescience-technology

25 June 2020 Scientists in the Hackett group at EMBL Rome doing lab work

Silencing the SARS-CoV-2 receptor with epigenetic modifications

Science & Technology EMBL scientists develop a new molecular tool to prevent SARS-CoV-2 infection in mice. This tool is able to cause targeted epigenetic modifications of specific genes in specific cell populations. They will use it in mice to target airway cells that express the ACE2 protein – the receptor that…

2020

sciencescience-technology

22 May 2020

EMBL scientists investigate rare lung disease

Science & Technology Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…

2020

sciencescience-technology

9 July 2019 A model of CRISPR/Cas9

Wielding the genetic scissors

Science & Technology What CRISPR may bring for the future of biology, and how it is used at EMBL

2019

sciencescience-technology

24 May 2018 Daniel Elias Martin Herranz EMBL-EBI

PhD goals: why not start a company?

Lab MattersPeople & Perspectives EMBL-EBI PhD student launches start-up focusing on epigenetics and wellbeing

2018

lab-matterspeople-perspectives

15 January 2018 This mouse ovary and these immature eggs (in blue), can be used to study patterns of DNA methylation that affect only females.

Welcome: Matthieu Boulard

People & Perspectives New EMBL group leader investigates the mystery of heritable gene silencing

2018

people-perspectivesscience

30 November 2017 Portrait of Edith Heard

Edith Heard awarded Grand Prix Inserm 2017

EMBL AnnouncementsLab Matters EMBL Director General elect, Edith Heard, awarded 2017’s Grand Prix Inserm for her work in epigenetics

2017

embl-announcementslab-matters

11 July 2017

New name for EMBL’s site in Italy

EMBL AnnouncementsLab Matters EMBL’s unit in Italy changes name to better reflect new research focuses and highlight its location

2017

embl-announcementslab-matters

5 May 2017

Welcome: Jamie Hackett

People & Perspectives Meet Monterotondo’s new group leader for epigenetic reprogramming and inheritance, Jamie Hackett

2017

people-perspectivesscience

25 April 2017

Embryos use ancient viral DNA

Science & Technology EMBL scientists detect important function of genetic sequence our ancestors assimilated from a virus

2017

sciencescience-technology

13 April 2017 Artist's interpretation of the mouse epigenetic clock.

A race against the ageing clock

Science & Technology EMBL-EBI researchers identify mouse epigenetic clock that could help scientists understand ageing

2017

sciencescience-technology

18 November 2016 Artist interpretation of a human epigenome.

BLUEPRINT project delivers

Science & Technology BLUEPRINT: EMBL-EBI and the push to decipher the blood epigenome

2016

sciencescience-technology

20 August 2015

Life in 3D

Science & Technology EMBL scientists map ‘switches’ for distant control of gene expression.

2015

sciencescience-technology

25 June 2014

Taken out of context

Science & Technology Enabling neighbours: intact genes can cause cancer when placed near "enhancing" regions of DNA

2014

sciencescience-technology

25 May 2014

Insights into genetics of cleft lip

Science & Technology How a DNA stretch influences face formation and contributes to common congenital malformations

2014

sciencescience-technology

19 July 2012 The female (left) fruit fly, Drosophila melanogaster, is larger than the male (right). Image credit: EMBL.

Of flies and men

Science & Technology What do you get when you dissect 10 000 fruit-fly larvae? A team of researchers led by the EMBL- European Bioinformatics Institute (EMBL-EBI) in the UK and the Max Planck Institute of Immunobiology and Epigenetics (MPI) in Germany has discovered a way in which cells can adjust the activity of many…

2012

sciencescience-technology

6 March 2008

New revelations in epigenetic control shed light on breast cancer

Epigenetic regulation – modifications to the structure of chromatin that influence which genes are expressed in a cell – is a key player in embryonic development and cancer formation. Researchers at the European Molecular Biology Laboratory (EMBL) in Heidelberg now gained new insight…

2008

science

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