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cryo-electron tomography

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10 June 2022 A colourful structural model of the doughnut-shaped human nuclear pore complex seen from above.

Puzzling out the structure of a molecular giant

Science Scientists have solved several mysteries around the structure and function of a true molecular giant: the human nuclear pore complex. They created the most complete model of the complex thanks to combining the program AlphaFold2 with cryo-electron tomography, integrative modelling, molecular…

2022

science

21 December 2021 A model of the doughnut-shaped nuclear pore complex. Individual molecules are marked in various colours.

Observing the secret life of molecules inside the cell

Science EMBL Hamburg’s Kosinski Group, the Beck Laboratory at the Max Planck Institute of Biophysics, and colleagues at EMBL Heidelberg recorded the nuclear pore complex contracting in living cells. They visualised the movement with an unprecedented level of detail with help of new software called…

2021

science

20 April 2021 Black-and-white sphere with coronavirus spike protein structures and a two-layered ring of virus membrane superimposed.

Variations on a spike

Picture of the week What does coronavirus’s spike protein look like in 3D? EMBL scientists and colleagues used cryo-electron tomography and molecular dynamics simulations to find out.

2021

picture-of-the-week

3 September 2020 Left: Slice of a cell in grey. Right: Two 3D reconstructions of parts of the slice, showing the internal structure.

Nuclear pores in their natural context

Science Scientists from the Beck group have studied the 3D structure of nuclear pores in budding yeast. They show how the architecture of the nuclear pore complex differs inside cells compared to its form observed in vitro studies.

2020

science

23 June 2009 Lattice maps for immature HIV particles. The 3D computer reconstruction shows the immature Gag lattice of HIV that matures to form the protein shell of the infecious virus. Maps are shown in perspective such that hexamers on the rear surface of the particle appear smaller. The side of the particle toward the viewer lacks ordered Gag. IMAGE: John Briggs/EMBL

New electron microscopy images reveal the assembly of HIV

Science Scientists at the European Molecular Biology Laboratory (EMBL) and the University Clinic Heidelberg, Germany, have produced a three-dimensional reconstruction of HIV (Human Immunodeficiency Virus), which shows the structure of the immature form of the virus at unprecedented detail. Immature HIV is…

2009

science

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