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drug

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15 November 2023 Illustration showing a doorknob with a lock and many protein-marked keys floating towards it.

Illustration showing a doorknob with a lock and many protein-marked keys floating towards it.

The secret of molecular promiscuity

Promiscuity is critical for nourishment. How? This question lies at the focus of research by the Löw Group at EMBL Hamburg. Using structural biology methods, they explore how specialised molecules located in the cell membrane allow cells absorb nutrients from their environment.

EMBLetc

2023

17 October 2023 Pill icons representing different antibiotic classes are seen exerting their effects on a bacterium, whose cell wall, membrane, and protein synthesis machinery (two different classes) can be seen as potential targets. Curved lines connect the pills to each other, representing synergies in drug interactions. More bacteria can be seen in the background.

Pill icons representing different antibiotic classes are seen exerting their effects on a bacterium, whose cell wall, membrane, and protein synthesis machinery (two different classes) can be seen as potential targets. Curved lines connect the pills to each other, representing synergies in drug interactions. More bacteria can be seen in the background.

Fighting antimicrobial resistance with new drug combinations

In an extensive investigation, EMBL researchers have tested over 10,000 drug combinations against some of the leading pathogenic bacteria carrying antimicrobial resistance and causing mortality.

SCIENCE & TECHNOLOGY

2023

sciencescience-technology

26 September 2022 Droplets are symbolically represented as concentric circles, with the inner circles displaying DNA sequences while the outer circles depict drug combinations as colourful pills.

Droplets are symbolically represented as concentric circles, with the inner circles displaying DNA sequences while the outer circles depict drug combinations as colourful pills.

Combi-seq: a leap forward for personalised cancer therapy

Researchers have come up with a way to test the efficacy of hundreds of anticancer drug combinations – simultaneously, rapidly, and accurately.

SCIENCE & TECHNOLOGY

2022

sciencescience-technology

8 December 2021 An illustration of the human gut, with coloured shapes representing bacteria. Three different drugs and drug combinations are shown affecting the bacteria, represented by changes in colour

An illustration of the human gut, with coloured shapes representing bacteria. Three different drugs and drug combinations are shown affecting the bacteria, represented by changes in colour

The impact of drugs on gut microbes is greater than we thought

Researchers studying a massive cohort of European patients have found that commonly prescribed drugs for cardiometabolic disorders can have long-term effects on the gut microbiome. Such effects can complicate the understanding of how disease affects the microbiome and must be taken into…

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

3 November 2021

In the left, a sketch of the human digestive tract, with pills in the stomach. On the right, a magnifying glass shows a model of the peptide transporter 1 in the cell membrane in the intestine wall. The pills from the left part of the image form a path made of smaller particles, and individual molecules represented by structural formulas. The path connects the intestine on the left to the opening of PepT1 and continues on the other side of the intestine wall. Individual drug molecules enter PepT1 and are transported to the other side of the cell membrane.

Structure of a promiscuous protein will help scientists design better drugs

Scientists at EMBL Hamburg determined the molecular structure of Peptide Transporters 1 and 2. The findings will enable developing drugs that more efficiently pass from the gut to target tissues.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

8 September 2021 Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.

Illustration of two halves of a pill, which releases chemical molecules that are taken up by gut bacteria in the vicinity.

Common medications accumulate in gut bacteria

A new collaborative study led by EMBL group leaders Kiran Patil, Nassos Typas, and Peer Bork has found that common medications accumulate in human gut bacteria. This process reduces drug effectiveness and affects the metabolism of common gut microbes, thereby altering the gut microbiome.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

9 February 2021 An artistic representation of how bioinformatics allows study of the SARS-CoV-2 infection process. On the left, coronaviruses are approaching a human face contour. On the right, protein structures and a network of connections represent bioinformatic analysis.

An artistic representation of how bioinformatics allows study of the SARS-CoV-2 infection process. On the left, coronaviruses are approaching a human face contour. On the right, protein structures and a network of connections represent bioinformatic analysis.

Protein sequences provide clues to how SARS-CoV-2 infects cells

Researchers at EMBL Heidelberg have identified sequences in human proteins that might be used by SARS-CoV-2 to infect cells. They have discovered that the virus might hijack certain cellular processes, and they discuss potentially relevant drugs for treating COVID-19.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

29 September 2020 A metal rack holding glass test tubes with yellow and red solutions in them.

A metal rack holding glass test tubes with yellow and red solutions in them.

Colourful test tubes

To study the effect of commonly used drugs on bacterial envelopes, EMBL scientists applied a biochemical assay using a colour reaction. The deeper the red, the stronger the disruptive effect of the drug.

SCIENCE & TECHNOLOGY

2020

picture-of-the-weekscience-technology

8 September 2020

Fighting cardiovascular disease with acne drug

Researchers have found the cause of dilated cardiomyopathy – a leading cause of heart failure – and identified a potential treatment for it: a drug already used to treat acne.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

1 July 2020

New Informatics Science Director at Open Targets, Ellie McDonagh

Welcome: Ellie McDonagh

Open Targets welcomes new Informatics Science Director

LAB MATTERS PEOPLE & PERSPECTIVES

2020

lab-matterspeople-perspectives

15 April 2020

Identifying how potential COVID-19 drugs work

EMBL researchers are studying how drugs that have shown good results against COVID-19 work in living cells

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

22 January 2020

Antibody engineering for therapy and diagnosis

The new EMBL spinoff company Araxa Biosciences GmbH aims to set new standards for the development of antibody-based therapeutics and diagnostics

LAB MATTERS SCIENCE & TECHNOLOGY

2020

lab-mattersscience-technology

20 January 2020

Melting reveals drug targets in a living organism

EMBL scientists identify drug targets in blood and organs

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

3 June 2019 Influenza polymerase (light cyan) in the process of synthesising messenger RNA (slate blue).

Influenza polymerase (light cyan) in the process of synthesising messenger RNA (slate blue).

Paving the way for new flu drugs

Snapshots of the flu virus replication machine in action

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

11 March 2019 A visualisation of a membraneless organelle in the green-yellow style of the data presented in the Nature Communications paper

A visualisation of a membraneless organelle in the green-yellow style of the data presented in the Nature Communications paper

ATP affects proteome-wide solubility

Scientists develop technology to measure how ATP concentration affects protein solubility in cells

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

23 January 2019 New Open Targets Director, Ian Dunham in EMBL-EBI South Building

New Open Targets Director, Ian Dunham in EMBL-EBI South Building

New Open Targets Director appointed

New director drives drug discovery partnership forward

LAB MATTERS PEOPLE & PERSPECTIVES

2019

lab-matterspeople-perspectives

6 July 2018 E. coli bacteria colored in heat gradient. IMAGE: Aleksandra Krolik / EMBL

E. coli bacteria colored in heat gradient. IMAGE: Aleksandra Krolik / EMBL

Melting bacteria to decipher antibiotic resistance

EMBL scientists investigate how bacteria melt to study their reaction to drugs

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

4 July 2018

Combining antibiotics changes their effectiveness. IMAGE: Aleksandra Krolik / EMBL

Combining antibiotics changes their effectiveness

Combining antibiotics with each other, non-antibiotic drugs or food additives can alter their effectiveness

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

22 June 2018

Miniature testing of drug pairs on tumour biopsies

Combinations of cancer drugs can be quickly and cheaply tested using a novel microfluidic device

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

19 March 2018

Commonly used drugs affect our gut bacteria.

Commonly used drugs affect our gut bacteria

One in four drugs with human targets inhibit the growth of bacteria in the human gut, and may promote antibiotic resistance, EMBL researchers report in Nature

SCIENCE & TECHNOLOGY

2018

sciencescience-technology

11 August 2013

From fireman to arsonist

Like a fireman who becomes an arsonist, a protein that prevents cells becoming cancerous can also cause tumours, scientists at the European Molecular Biology Laboratory (EMBL) in Grenoble, France, have discovered. The finding, published today in Nature Structural and Molecular Biology, stems…

SCIENCE & TECHNOLOGY

2013

sciencescience-technology

21 June 2012

Flu fighters

Savira pharmaceuticals GmbH, a spin-off of the European Molecular Biology Laboratory (EMBL) based in Vienna, Austria, has signed a collaboration and license agreement with Roche, thus further strengthening the links between fundamental research and major pharmaceutical development companies. This…

SCIENCE & TECHNOLOGY

2012

sciencescience-technology

11 July 2008

Teaching old drugs new tricks

Researchers from the European Molecular Biology Laboratory (EMBL) discovered a new way to make use of drugs’ unwanted side effects. They developed a computational method that compares how similar the side effects of different drugs are and predicts how likely the drugs act on the same target…

SCIENCE & TECHNOLOGY

2008

sciencescience-technology

11 February 2007

Putting an old drug to a new use

We all know that iron deficiencies are dangerous, but also too much iron is bad for our health. Our body stores excess iron in various tissues, where it can lead to organ failure and even death if not treated before irreversible damage has occurred. Researchers from the Innsbruck Medical…

SCIENCE & TECHNOLOGY

2007

sciencescience-technology

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