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Chromatin

stem cells neurons differentiation

From stem cells to neurons

Scientists at EMBL Heidelberg have investigated stem cells and how they differentiate to become neurons. Their approach included an assessment of the complex interplay of molecules during the differentiation process and generated fundamental new insights into the role of a protein called Sox2 in…

By Fabian Oswald

Science

EMBL scientists investigate rare lung disease

Researchers in EMBL’s Zaugg group have studied the causes of pulmonary arterial hypertension (PAH), a rare disease that causes high blood pressure in the arteries of the lungs. The study, carried out in collaboration with Stanford University School of Medicine, compared lung cells of patients…

By Fabian Oswald

Science

Dancing chromosomes

In human cells, the genetic material is packaged into 23 different DNA molecules, the chromosomes. Each chromosome is present in two copies, one inherited from the paternal sperm, and the other from the maternal egg. During most of the cell’s life, chromosomes take the shape of long,…

By Mehdi Khadraoui

Picture of the week

TF bound to DNA

A classification tool for transcription factors

The software diffTF quantifies activity of transcription factors and predicts their mode of action…

By Fabian Oswald

Science

Choanocyte chamber of sponge, with neuroid cell

Neural pathways

Exploring the diverse routes by which EMBL scientists are driving forward neurobiology…

By Cella Carr

Science

The pyramids represent chromatin domains in the wild-type situation. The reflection in the water below represents the rearrangements in the mutant fruit fly chromosomes. At first glance the (regulatory) landscapes look very similar, but there are lots of changes to the topology, and yet these have little impact on the nature of the landscape (gene expression). IMAGE: Beata Edyta Mierzwa in collaboration with EMBL.

Rearranging chromosomes

Does rearranging chromosomes affect their function? EMBL scientists reveal uncoupling of 3D chromatin organisation and gene expression.…

By Iris Kruijen

Science

Molecular and behavioural consequences of the SETD5 mutation. IMAGE: Isabel Chew

Molecular and behavioural effects of SETD5 mutation

Scientists uncover effects of mutation that can cause autism and intellectual disability…

By Guest author(s)

Science

In this image of developing cells, fluorescent molecules reveal DNA (blue), part of the X chromosomes (red), and the Xist RNA (white). The green colour shows a region of the cells’ nuclei called the nuclear lamina. IMAGE: Mikael Attia and Edith Heard/Institut Curie

The scientific origins of Edith Heard

EMBL’s next Director General reflects on the questions that drive her research…

By Guest author(s)

Science

Information (arrows) emanating out of chromatin to give rise to different cell types. IMAGE: Campbell Medical Illustration

Chromatin usage reveals developmental trajectories

EMBL scientists show how chromatin usage in individual cells reveals developmental trajectories…

By Iris Kruijen

Science

Judith Zaugg and Mariana Ruiz Velasco. PHOTO: Marietta Schupp/EMBL

Loops in DNA affect which proteins are coded

EMBL scientists unveil how 3D chromatin structure affects RNA splicing…

By Berta Carreño

Science

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