Structure and function of RNA-protein complexes
Our brief summary of the recent progress in understanding the structure and function of the Integrator complex was just published in Transcription. Moritz M. Pfleiderer & Wojciech P. Galej (2022) Emerging insights into the function and structure of the Integrator complex. Transcription,…
Every year we take a day off and go skiing together. This time we went to Alpe d’Huez. Beautiful mountains and fantastic weather, only 1.5h away from Grenoble!
https://www.science.org/doi/10.1126/science.abm4245
Our snowshoeing trip had to be cancelled due to bad weather conditions, but at least we made it to a fondue restaurant and enjoyed some nice winter food!
Our new paper on the structure of the human U2 snRNP was just published in Science ! In human cells protein-coding genetic information is punctuated with non-coding segments – Introns, which need to be removed from pre-mRNA by the spliceosome. U2 snRNP recognises a conserved position within…
Sonal Lagad is our newest lab member. She joined EMBL International PhD Programme in August to work on pre-mRNA splicing.
Moritz Pfleiderer, the first PhD student in the Galej group, has successfully defended his thesis last Thursday. During the PhD, Moritz studied multi-subunit Integrator complex, which is involved in transcription attenuation and snRNAs 3′-end processing. His results were recently published in…
Molecular Cell published an interview with Wojtek and his colleagues, Max Wilkinson and Sebastian Fica from the Nagai group reflecting on the last 6 years of their work on the spliceosome structure. The associated paper on the Ci spliceosome intermediate was the first publication to go through the…
The latest #cryoEM structure from Nagai group at MRC LMB in Cambridge identifying a new spliceosome assembly intermediate (Ci complex) is now published in Molecular Cell. The paper contains the most complete and accurate depiction of the catalytic spliceosome to date and identifies a new functional…
Our newest paper describing the structure of the catalytic core of the Integrator complex is online now in Molecular Cell. Integrator complex was discovered more than 15 years ago as a specialised endonuclease responsible for the 3’-end processing of spliceosomal snRNAs. More recent studies…