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Chromosome structure

3D reconstruction of parental chromosomes in the mouse embryo

How chromosome structure influences development

EMBL researchers in the Heard group at EMBL Heidelberg explore the interaction between DNA organisation and gene expression in the early…

By Fabian Oswald

Science
Structural biology image of the condensin complex.

Intact chromosomes during cell division

The mystery of how condensin maintains the integrity of the genome during cell…

By Patrick Mueller

Science
As a cell prepares to divide, the chromosomes (shown here in pink) condense, becoming more tightly coiled and easier to observe under the microscope. The faint structure in the centre is a cell nucleus in which the chromosomes are in their usual decondensed state.

Exploring genetic variation

EMBL group leader Jan Korbel reflects on his scientific origins and current…

By Edward Dadswell

Science
A condensin protein complex creates a loop in DNA. IMAGE: Cees Dekker Lab TU Delft/Scixel

Loops, loops and loops: how DNA gets organised

Researchers from Delft University and EMBL crack the mystery of condensin’s neat DNA loop…

By Iris Kruijen

Science

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