biochemistry Archives

15 October 2025

ChEMBL 36 is live

ChEMBL 36 release release brings the total number of drug targets to 17, 803 and provides access to 2.8 million distinct compounds.

2025

updates-from-data-resources

23 October 2024

BioChemGraph: Unifying structural and bioactivity data to accelerate drug discovery

In the era of data-driven biology, integrating information from different resources is essential yet often challenging. The BioChemGraph project addresses this challenge by creating infrastructure that consolidates structural, functional, and biochemical annotations for small molecules and their…

2024

updates-from-data-resources

15 November 2023 Female scientist

Advocating for a generalist approach to science and life

Sara Fahs, who did her PhD from EMBL Heidelberg and is one of the newest members of the EMBL alumni association board, writes about key insights from her journey in science and her work on medicinal chemistry, during a career spanning academia and industry.

EMBLetc

2023

5 February 2021 Artistic representation of the structure of the three proteins forming Integrator’s catalytic core.

At the core of the Integrator complex

A new paper from the Galej group at EMBL Grenoble describes the structure of key parts of the Integrator complex, involved in gene expression.

SCIENCE & TECHNOLOGY

2021

sciencescience-technology

9 December 2020 Portrait photo of EMBL group leader Miki Ebisuya against a green background.

EMBL group leader Miki Ebisuya receives ERC Consolidator Grant

Funding by the European Research Council (ERC) will support research on the timing of developmental processes in mammals

EMBL ANNOUNCEMENTS LAB MATTERS

2020

embl-announcementslab-matters

7 October 2020 Graphical representation of genome editing tool CRISPR in green and pink. Nobel prize medal on the right.

Powerful genome editing tool recognised by Nobel Prize in Chemistry

The genome editing tool CRISPR–Cas9 – which plays a critical role in EMBL’s research – was recognised by the Nobel Prize in Chemistry.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

29 September 2020 A metal rack holding glass test tubes with yellow and red solutions in them.

Colourful test tubes

To study the effect of commonly used drugs on bacterial envelopes, EMBL scientists applied a biochemical assay using a colour reaction. The deeper the red, the stronger the disruptive effect of the drug.

SCIENCE & TECHNOLOGY

2020

picture-of-the-weekscience-technology

18 September 2020 Composite image of mouse cells and human cells showing different levels of luminescence, indicated as different colours.

Human and mouse cells run at different speeds

The internal clock that governs the development of embryos ticks slower for humans than for mice. Differences in the speed of biochemical reactions underlie the differences between species in the tempo of development.

SCIENCE & TECHNOLOGY

2020

sciencescience-technology

3 July 2019 Super-resolution image of the basal surface of a cellularising Drosophila embryo.

Actin crosslinking plays key role in tissue morphogenesis

New insights into mechanisms behind embryonic development

SCIENCE & TECHNOLOGY

2019

sciencescience-technology

2 March 2018 HiGlass (http://higlass.io) is an exploratory visualization tool for genomic data developed by Nils Gehlenborg and his team that provides analysts with a flexible interface to explore genomic and epigenomic data, including genome wide interactions, across multiple scales. IMAGE: Nils Gehlenborg

HiGlass (http://higlass.io) is an exploratory visualization tool for genomic data developed by Nils Gehlenborg and his team that provides analysts with a flexible interface to explore genomic and epigenomic data, including genome wide interactions, across multiple scales. IMAGE: Nils Gehlenborg

Kendrew and Philipson Awards Winners 2018

EMBL recognises the outstanding work of alumni with the John Kendrew and Lennart Philipson Awards

EMBL ANNOUNCEMENTS

2018

alumniembl-announcements

8 December 2017 Alasdair McDowall (left), an EMBL research technician 1978-1987, and Jacques Dubochet (right), EMBL group leader 1978-1987, together in Heidelberg

Alasdair McDowall (left), an EMBL research technician 1978-1987, and Jacques Dubochet (right), EMBL group leader 1978-1987, together in Heidelberg

Alasdair McDowall’s slow road to flash freezing

How a research technician with a master’s degree contributed to Nobel Prize-winning work

PEOPLE & PERSPECTIVES

2017

alumnipeople-perspectives

4 October 2017 Jacques Dubochet visiting EMBL in 2015 to receive the inaugural Lennart Philipson Award

Jacques Dubochet awarded Nobel Prize for chemistry

EMBL alumnus recognised for cryo-electron microscopy work

EMBL ANNOUNCEMENTS

2017

embl-announcementsscience

10 August 2016 Paris at night. IMAGE: NASA (M. Justin Wilkinson, Texas State University, Jacobs Contract at NASA-JSC)

Life in the periphery

Storage of pre-made nuclear pores allows for rapid cell division in fruit fly embryos

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

28 July 2016 Landline vs. smartphone: the RNA-binding domain lets proteins do more than just talk to other proteins

Discovering protein smartphones

New technique reveals uncharted docking sites in RNA-binding proteins

SCIENCE & TECHNOLOGY

2016

sciencescience-technology

9 October 2015 The ultrafast and yet selective binding allows the receptor (gold) to rapidly travel through the pore filled with disordered proteins (blue) into the nucleus, while any unwanted molecules are kept outside. IMAGE: Mercadante /HITS

The ultrafast and yet selective binding allows the receptor (gold) to rapidly travel through the pore filled with disordered proteins (blue) into the nucleus, while any unwanted molecules are kept outside. IMAGE: Mercadante /HITS

Floppy but fast

Spaghetti-like proteins are surprisingly effective 'keys'

SCIENCE & TECHNOLOGY

2015

sciencescience-technology

20 August 2015

First, find your membrane

Collaboration between scientists reveals collaboration between lipids.

SCIENCE & TECHNOLOGY

2015

sciencescience-technology

20 October 2014

Breaking boundaries

How Nobel-winning work by alumnus Stefan Hell shapes and inspires current EMBL scientists' research.

SCIENCE & TECHNOLOGY

2014

sciencescience-technology

6 August 2014

Clarity in the cold

How fruit flies beat the cold, plus the value of precisely controlled experiments and detailed analysis

SCIENCE & TECHNOLOGY

2014

sciencescience-technology

4 August 2014 Explosion on gene motif

On editing the genetic code

Edward Lemke edits special issue of ChemBioChem on boom of technology for genetic code expansion

SCIENCE & TECHNOLOGY

2014

sciencescience-technology

1 July 2014 Matthias Wilmanns receives his membership certificate

Awards & Honours

EMBL scientists regularly receive prestigious awards - meet the latest honourees

LAB MATTERS

2014

lab-matters

17 June 2011 Condensin loops around several strands of DNA, keeping it coiled up and easier to transport. (Artistic impression) Image credits: EMBL/ P. Riedinger

Condensin loops around several strands of DNA, keeping it coiled up and easier to transport. (Artistic impression) Image credits: EMBL/ P. Riedinger

Keeping it together

As any rock-climber knows, trailing a long length of rope behind you is not easy. A dangling length of rope is unwieldy and hard to manoeuvre, and can get tangled up or stuck on an outcropping. Cells face the same problem when dragging chromosomes apart during cell division. The chromosomes are…

SCIENCE & TECHNOLOGY

2011

sciencescience-technology

6 December 2005

Setting the standard for computer models of life

In the December 6 issue of Nature Biotechnology, scientists from 14 different organizations around the world, including the EMBL-European Bioinformatics Institute, propose a new quality standard for biochemical models. MIRIAM [for Minimum information requested in the annotation of biochemical…

LAB MATTERS SCIENCE & TECHNOLOGY

2005

lab-mattersscience-technology

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