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Systems (epi)genetics to study the basis of complex traits and diseases
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Resources & Teaching
GRaNIE and GRaNPA: Inference and evaluation of enhancer-mediated gene regulatory networks applied to study macrophages
(
BioRxiv 2021
)
Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions
(
Nature Communications 2020
)
Predictive features of gene expression variation reveal mechanistic link with differential expression
(
Mol. Sys. Biol. 2020)
Quantification of differential transcription factor activity and multiomic-based classification into activators and repressors: diffTF
(
Cell Reports 2019
)
CTCF-Mediated Chromatin Loops between Promoter and Gene Body Regulate Alternative Splicing across Individuals
(
Cell Systems 2017
)
SNPhood: Investigate, quantify and visualise the epigenomic neighbourhood of SNPs using NGS data
(
Bioinformatics 2016
)
Genetic Control of Chromatin States and Gene Expression in Humans Involves Local and Distal Chromosomal Interactions
(
Cell 2015
)
Extensive Variation in Chromatin States Across Humans
(
Science 2013
)
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