Systems (epi)genetics to study the basis of complex traits and diseases
This work co-supervised by Min Noh and Mikael Marttinen describes our technology for highthroughput and highly multiplexed joint RNA/ATAC profiling in single cells. Congratulations to Sara, Umut, Annique and all the authors! This method has already sparked many collaborations – feel free to…
This is work in collaboration with our partners from GSK. Congratulations to Neha, Nila and all of the authors! Daga N, H. Servaas N, Kisand K, Moonen D, Arnold C, Reyes-Palomares A, Kaleviste E, Kingo K, Kuuse R, Ulst K, Steinmetz L, Peterson P, Nakic N, Zaugg JB (2024). Integration of…
Check it out here!
Check it out here!
Using gene-specific regulatory features we could predict how genes vary across individuals in fly and humans. Read the full paper here or a short lay summary in the EMBL news.
EMBL news coverage of our article: From stem cells to neurons Genomic Rewiring of SOX2 Chromatin Interaction Network during Differentiation of ESCs to Postmitotic NeuronsCellular differentiation requires dramatic changes in chromatin organization, transcriptional regulation, and protein production.…
This work results from a collaboration with 2 groups at Stanford. Check it out here: https://www.nature.com/articles/s41467-020-15463-x Our main take-home messages from the study:1) Chromatin is more sensitive than RNA to capture a cell’s regulatory state2) Chromatin changes are best…
Check out here how we combine high-throughput genomics data and statistical learning to gain mechanistic insights and functional consequences of cooperative transcription factor binding: Mechanistic insights into transcription factor cooperativity and its impact on protein-phenotype interactions…
Interested in quantifying differential TF activity and classifying TFs into activators and repressors? Then you should check out our recent manuscript and associated tool diffTF: Quantification of Differential Transcription Factor Activity and Multiomics-Based Classification into Activators and…
This is a great collaboration with our MMPU partner lab headed by Caroline Pabst. Check it out here: http://www.bloodjournal.org/content/early/2019/05/10/blood.2018862383?sso-checked=true Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated…