This work describes our methods for inferring enhancer-mediated gene regulatory networks and how we can use these networks to identify transcription factors that drive differential expression between two conditions.

Congratulations to Aryan, Christian and all the co-authors (this has been a massive group effort with many people from the Zaugg group contributing essential analyses)!

Check it out here: https://www.embopress.org/doi/full/10.15252/msb.202311627

GRaNIE and GRaNPA: inference and evaluation of enhancer-mediated gene regulatory networks.

Kamal A*, Arnold C*, Claringbould A, Moussa R, Servaas NH, Kholmatov M, Daga N, Nogina D, Mueller-Dott S, Reyes-Palomares A, Palla G, Sigalova O, Bunina D, Pabst C, Zaugg JB

Molecular systems biology, 2023