Steinmetz Group

Systems genetics and precision health

Research highlights

Select Publications:

Article:Transcriptional neighborhoods regulate transcript isoform lengths and expression levels. Brooks A*, Hughes A*, Clauder-Muenster S, Mitchell L, Boeke J, Steinmetz LM#. Science (2022).
DOI | Free-access Link
Article:High-speed fluorescence image-enabled cell sorting. Schraivogel D, Kuhn TM, Rauscher B, Rodríguez-Martínez M, Paulsen M, Owsley K, Middlebrook A, Tischer C, Ramasz B, Ordoñez-Rueda D, Dees M, Cuylen-Haering S#, Diebold E#, Steinmetz LM#. Science (2022).
DOI | Free-access Link
Article: Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Zhu C*, Wu J*, Sun H, Briganti F, Meder B, Wei W, Steinmetz LM. Nature Communications (2021).
Article:Targeted Perturb-seq enables genome-scale genetic screens in single cells.
Schraivogel D*, Gschwind AR*, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM. Nature methods (2020).
DOI | PubMed
Article: Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Baccin C*, Al-Sabah J*, Velten L*, Helbling PM, Grünschläger F, Hernández-Malmierca P, Nombela-Arrieta C, Steinmetz LM, Trumpp A, Haas S. Nature cell biology (2019).
DOI | PubMed

Zuo E*, Sun Y*, Wei W*, Yuan T*, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Cytosine base editor generates substantial off-target single nucleotide variants in mouse embryos. Science. (2019).
DOI | PubMed
Article: Roy KR*, Smith JD*, Vonesch SC*, Lin G, Tu CS, Lederer AR, Chu A, Suresh S, Nguyen M, Horecka J, Tripathi A, Burnett WT, Morgan MA, Schulz J, Orsley KM, Wei W, Aiyar RS, Davis RW, Bankaitis VA, Haber JE, Salit ML, St Onge RP, Steinmetz LM. Multiplexed precision genome editing with trackable genomic barcodes in yeast. Nature Biotechnology (2018).
DOI | PubMed
Article:Velten L*, Haas SF*, Raffel S*, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MAG, Steinmetz LM. Human haematopoietic stem cell lineage commitment is a continuous process. Nat Cell Biol. (2017).
DOI | PubMed
Article:Pelechano V*, Wei W*, Steinmetz LM. Widespread co-translational RNA decay reveals ribosome dynamics. Cell. (2015).
DOI | PubMed
Article: Pelechano V*, Wei W*, Steinmetz LM. Extensive transcriptional heterogeneity revealed by isoform profiling. Nature. (2013).
DOI | PubMed
Article:Xu Z*, Wei W*, Gagneur J, Perocchi F, Clauder-Münster S, Camblong J, Guffanti E, Stutz F, Huber W, Steinmetz LM. Bidirectional promoters generate pervasive transcription in yeast. Nature. (2009).
DOI | PubMed
Article:Steinmetz LM*, Scharfe C*, Deutschbauer AM, Mokranjac D, Herman ZS, Jones T, Chu AM, Giaever G, Prokisch H, Oefner PJ, Davis RW. Systematic screen for human disease genes in yeast. Nature Genet. (2002).
DOI | PubMed
Article: Steinmetz LM*, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW. Dissecting the architecture of a quantitative trait locus in yeast. Nature. (2002).
DOI | PubMed

Features on Steinmetz Lab Research:

See here for the full collection of EMBL news articles on our work

Cover for Jan 21, 2022 issue of Science Magazine. Cover story by Schraivogel et al.
Image Credit: illustratoren.de/TobiasWuestefeld
Image credit: illustratoren.de/TobiasWuestefeld. Cover design: Erin Dewalt.
Nature Microbiology cover article for Nadal-Ribelles et al. Nat Microbiol (2019)
Image: illustratoren.de/TobiasWuestefeld.
Cover Design: Lauren Heslop.
Nature Cell Biology cover article: Velten et al. Nat Cel Bio (2017)
Image credit: illustratoren.de/TobiasWuestefeld
G3 cover article from Hennig et al, G3 (2018)
Image: Aleksandra Krolik (EMBL)
Genome Research cover article from Huang et al., Genome Research (2016)
Image: Sophia Genetics
G3 cover image from Landry et al., G3, 2013
Image: Petra Riedinger, Paul Theodor Pyl & Jonathan Landry
Image: Hubert Becker
Image: Petra Riedinger & Stefan Wilkening