Blog – Kowalinski Group

Kowalinski Group

Structural biology of macromolecular protein-RNA complexes

The Kowalinski group investigates the architecture and mechanisms of macromolecular complexes involved in cellular RNA editing and modification.



Publication Alert

ADAT2/3 structure bound to tRNA out in Nature Commincations. Structural basis for sequence-independent substrate selection by eukaryotic wobble base tRNA deaminase ADAT2/3. Dolce LG, Zimmer AA, Tengo L, Weis F, Rubio MAT, Alfonzo JD, Kowalinski E Nature communications, 2022…


First preprint from the lab!

Sequence-independent substrate selection by the eukaryotic wobble base deaminase ADAT2/3 involves multiple protein domains and distortion of the tRNA anticodon loop The essential deamination of adenosine A34 to inosine at the wobble base is the individual tRNA modification with the greatest effects…