GeneCore is the in-house genomics service centre at EMBL
Genome-wide chromatin and DNA methylation analysis refers to a set of sequencing-based methods that map how the genome is regulated, not just what the DNA sequence is. Chromatin assays measure features such as DNA accessibility and protein–DNA interactions that influence which genomic regions are active, while DNA methylation assays measure chemical modifications on DNA that help control gene activity and maintain cellular identity. Together, these approaches provide a genome-wide view of regulatory states and epigenetic changes across cell types, developmental stages, or experimental conditions.
Assays that profile chromatin organization and regulatory activity across the genome, such as open chromatin regions, transcription factor binding, and histone modifications, helping identify active promoters, enhancers, and other regulatory elements.
Assays that measure cytosine methylation patterns across the genome to reveal epigenetic regulation, cell-type specific methylation signatures, and methylation changes associated with development, environment, or disease.