GeneCore is the in-house genomics service centre at EMBL
You sequence an organism’s DNA and either assemble the genome from scratch or compare the reads with an existing reference genome to identify genetic differences such as single nucleotide variants, small insertions/deletions, and larger structural changes, depending on the data and analysis. These approaches are used either when no high-quality reference genome is available or when a suitable reference exists and you want to study genetic variation across samples, individuals, or conditions.
De novo genomic DNA sequencing is an approach in which an organism’s DNA is sequenced and the genome is assembled from scratch by overlapping reads into longer sequences, such as contigs and scaffolds. It is used when no high-quality reference genome is available or when building a new reference for a genetically distinct strain, species, or population.
Genomic DNA re-sequencing is an approach in which an organism’s DNA is sequenced and the reads are compared with an existing reference genome to identify genetic differences, including single nucleotide variants, small insertions/deletions, and, depending on the data and analysis, larger structural changes. It is used when a suitable reference genome is available and you want to study genetic variation across samples, individuals, or conditions.